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            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
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                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="entry name" value="Ribulokinase"/>
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            <dbReference type="ARBA" id="ARBA00023277"/>
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            <dbReference type="Pfam" id="PF02782"/>
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        <source>
            <dbReference type="EMBL" id="KAG5464566.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="557" mass="60675" checksum="06A03D75E4997C24" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G0F0</accession>
    <name>A0A836G0F0_9TRYP</name>
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        <recommendedName>
            <fullName evidence="3">ABC transporter domain-containing protein</fullName>
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    <gene>
        <name evidence="4" type="ORF">LSCM4_02060</name>
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    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
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    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="AAA+_ATPase"/>
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    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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            <begin position="7"/>
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    </feature>
    <feature type="domain" description="ABC transporter" evidence="3">
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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        <source>
            <dbReference type="PROSITE" id="PS50893"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5472737.1"/>
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            <dbReference type="Proteomes" id="UP000674143"/>
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    </evidence>
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<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name type="scientific">Leishmania orientalis</name>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_067204171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G0J6"/>
    <dbReference type="GeneID" id="92358105"/>
    <dbReference type="KEGG" id="loi:92358105"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="647"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="655"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5472812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="747" mass="81243" checksum="0BAD25F6B2DD5654" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G3D9</accession>
    <name>A0A836G3D9_9TRYP</name>
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        <recommendedName>
            <fullName evidence="3">PUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_00012</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058205.1">
        <property type="nucleotide sequence ID" value="XM_067202104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G3D9"/>
    <dbReference type="SMR" id="A0A836G3D9"/>
    <dbReference type="GeneID" id="92356038"/>
    <dbReference type="KEGG" id="loi:92356038"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09212">
        <property type="entry name" value="PUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036339">
        <property type="entry name" value="PUB-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018997">
        <property type="entry name" value="PUB_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46713">
        <property type="entry name" value="F13M7.16 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46713:SF1">
        <property type="entry name" value="F13M7.16 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09409">
        <property type="entry name" value="PUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143503">
        <property type="entry name" value="PUG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PUB" evidence="3">
        <location>
            <begin position="281"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="105"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5464574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="367" mass="40441" checksum="03B80A40E00056C2" modified="2021-09-29" version="1">MSSDGRDAEAPRAGEPAAVAKMAVERSSSSEMSDSGTYTISQTLFDALTARGFSENAIKKSVVAGCIDEATSAKWIQMHEGHPELDSALEEGVAVIIKAKRVLTEAEREAKVRELQERVRRTKEQEQLALQRKERERLEMGRKMVRMKNELDDVRRRMHVEEARRESAADLEARRRIRVQIAADRLERKGHTKAEALALAEKEFEEAATAARAEAAARLSQLQGTQAPAQTTAPASGGTWNLSSITAASSTPNKLVELFAGDAPTCPQALVDSIRKREPAEKTSECLRTLRLILGNVVADPFDAKKRTLRVSTKAFRDTILSVDEAPQLLRWCGFALSSDAANNQTLCLSTVVMRRLYQVLALLGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G432</accession>
    <name>A0A836G432_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_00427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058610.1">
        <property type="nucleotide sequence ID" value="XM_067202509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G432"/>
    <dbReference type="GeneID" id="92356443"/>
    <dbReference type="KEGG" id="loi:92356443"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="545"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="928"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="408"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="495"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="545"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="935"/>
            <end position="952"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5464979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1012" mass="105597" checksum="B8B9DF58E3D3F814" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G4A2</accession>
    <name>A0A836G4A2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Intraflagellar transport protein 81 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Carnitine deficiency-associated protein expressed in ventricle 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">LSCM4_00780</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the intraflagellar transport (IFT) complex B: together with IFT74, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds tubulin via its CH (calponin-homology)-like region. Required for ciliogenesis. Required for proper regulation of SHH signaling. Plays an important role during spermatogenesis by modulating the assembly and elongation of the sperm flagella.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the IFT81 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059503.1">
        <property type="nucleotide sequence ID" value="XM_067202853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G4A2"/>
    <dbReference type="SMR" id="A0A836G4A2"/>
    <dbReference type="GeneID" id="92356787"/>
    <dbReference type="KEGG" id="loi:92356787"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.70:FF:000001">
        <property type="entry name" value="Intraflagellar transport protein 81 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.70">
        <property type="entry name" value="Intraflagellar transport protein 81, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029600">
        <property type="entry name" value="IFT81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041146">
        <property type="entry name" value="IFT81_CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043016">
        <property type="entry name" value="IFT81_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15614">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 81 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15614:SF2">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 81 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18383">
        <property type="entry name" value="IFT81_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="8 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0221">Differentiation</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0744">Spermatogenesis</keyword>
    <feature type="domain" description="IFT81 calponin homology" evidence="17">
        <location>
            <begin position="32"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="366"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00055755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00073058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00079903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF18383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG5467701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="719" mass="81897" checksum="A3259E2624FAD706" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G4W0</accession>
    <name>A0A836G4W0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable eukaryotic initiation factor 4A</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">ATP-dependent RNA helicase eIF4A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">LSCM4_01497</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family. eIF4A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059239.1">
        <property type="nucleotide sequence ID" value="XM_067203548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G4W0"/>
    <dbReference type="SMR" id="A0A836G4W0"/>
    <dbReference type="GeneID" id="92357482"/>
    <dbReference type="KEGG" id="loi:92357482"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="17">
        <location>
            <begin position="437"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="468"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="675"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="832"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="13">
        <location>
            <begin position="437"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="287"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="343"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="841"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="868"/>
            <end position="882"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG5466349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="882" mass="96934" checksum="89C1C3733DD16BD1" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G8Q6</accession>
    <name>A0A836G8Q6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA uridylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_02930</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>RNA(n) + UTP = RNA(n)-3'-uridine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14785"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17348"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173116"/>
            <dbReference type="EC" id="2.7.7.52"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.52" evidence="3"/>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060502.1">
        <property type="nucleotide sequence ID" value="XM_067204950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G8Q6"/>
    <dbReference type="SMR" id="A0A836G8Q6"/>
    <dbReference type="GeneID" id="92358884"/>
    <dbReference type="KEGG" id="loi:92358884"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050265">
        <property type="term" value="F:RNA uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF41">
        <property type="entry name" value="TERMINAL URIDYLYLTRANSFERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="9">
        <location>
            <begin position="32"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="8">
        <location>
            <begin position="247"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5470236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="356" mass="39702" checksum="7C652EAFC7D5FCFF" modified="2021-09-29" version="1">MKGRVGRPIAAVGDVRAAVSRFCDEQLSRRLDTKPVVDVHEKVSACVQAVDPTMTPYVFGSTAVLGVHERGSDVDLVCLSPTDVQDGKGADAVSEVAKGLQSDFLFRLSEVVKREHYLWDIDLVRRTRVPVLRVKGGFGSDRVSFDVTANRRNGVRNSALLRAYFTQCAEARWLSMVVKQWSKKTGLNASVDGGCITSYGWNIMVVYYLLRRKLVALVPVESCDVTNIAPMPPYMPLEAPQQGGQALADMLIDFVGYFLDEFSPETEVMSLTRPAGETTKEMLSWTKQAEDMARIRGEKIHYRWCIEDPYEYDLNVGRNVTPFKLMLLRKHLERARETALLLLPTPPAPAAAKSAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GD16</accession>
    <name>A0A836GD16_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_05733</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063438.1">
        <property type="nucleotide sequence ID" value="XM_067207665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GD16"/>
    <dbReference type="SMR" id="A0A836GD16"/>
    <dbReference type="GeneID" id="92361599"/>
    <dbReference type="KEGG" id="loi:92361599"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000100">
        <property type="entry name" value="Putative actin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="177"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="458"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5479727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="591" mass="62547" checksum="BEFA9A10FC76B5A3" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GGH2</accession>
    <name>A0A836GGH2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">39S ribosomal protein L36, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_03251</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060816.1">
        <property type="nucleotide sequence ID" value="XM_067205264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GGH2"/>
    <dbReference type="SMR" id="A0A836GGH2"/>
    <dbReference type="GeneID" id="92359198"/>
    <dbReference type="KEGG" id="loi:92359198"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5471699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="21778" checksum="07A8E8D4A022E85D" modified="2021-09-29" version="1">MLRCTPSARRALRATVQALNFFPLGYTCGPKNKQVLSPPNNLDGRTTHRMKKLQGSTDKHPGLVPRNKLKLHCECCRFHWVQDTLVVRCPAHPKEHNQREIWLQPTWTWGRQQPYQYYKYMPVNINPRTGMPLAREDAKGMNNERRSQGLPTKTRLLERERRGISRAITGLGIYNQRWQTRFPFAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GGW2</accession>
    <name>A0A836GGW2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycosomal membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_03988</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061917.1">
        <property type="nucleotide sequence ID" value="XM_067205980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GGW2"/>
    <dbReference type="GeneID" id="92359914"/>
    <dbReference type="KEGG" id="loi:92359914"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008733">
        <property type="entry name" value="PEX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652:SF52">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05648">
        <property type="entry name" value="PEX11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="1" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5474811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="24066" checksum="2419E11B546EA37B" modified="2021-09-29" version="1">MSDFEKLIKLLAQTDGRDKIYKFFAGFFKILAAVAAASQDPRAKAYGAIGNSIGSARSLMRMGKFVGDVPKLQKIADGVMAKGVAGTECKKFIEFFRTMCNSLYIMGDNAAFIAKHRLIPADAKCITKYSKIAQFWGFFLAAVLDLIALRAALQKRVSDISTSKKEAKAAVINLTKDASDVLVTMAAVGYLRSVWHPSAMTAGTLTCVSGGVATYLNWNKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GIJ5</accession>
    <name>A0A836GIJ5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Acyl-CoA oxidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_04310</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl-CoA oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062234.1">
        <property type="nucleotide sequence ID" value="XM_067206297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GIJ5"/>
    <dbReference type="SMR" id="A0A836GIJ5"/>
    <dbReference type="GeneID" id="92360231"/>
    <dbReference type="KEGG" id="loi:92360231"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003997">
        <property type="term" value="F:acyl-CoA oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005504">
        <property type="term" value="F:fatty acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033540">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA oxidase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000042">
        <property type="entry name" value="Acyl-CoA oxidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000058">
        <property type="entry name" value="Putative acyl-CoA oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012258">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002655">
        <property type="entry name" value="Acyl-CoA_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909">
        <property type="entry name" value="ELECTRON TRANSPORT OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909:SF250">
        <property type="entry name" value="PEROXISOMAL ACYL-COENZYME A OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01756">
        <property type="entry name" value="ACOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA oxidase C-terminal" evidence="4">
        <location>
            <begin position="575"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="717"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5475726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="765" mass="85661" checksum="F66891496274C171" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GIK5</accession>
    <name>A0A836GIK5_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_04326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062249.1">
        <property type="nucleotide sequence ID" value="XM_067206312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GIK5"/>
    <dbReference type="SMR" id="A0A836GIK5"/>
    <dbReference type="GeneID" id="92360246"/>
    <dbReference type="KEGG" id="loi:92360246"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="297"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="350"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="375"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="409"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="448"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="515"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5475741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="548" mass="55682" checksum="5DE067CB42376BF5" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GJ09</accession>
    <name>A0A836GJ09_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endochitinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_00189</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058379.1">
        <property type="nucleotide sequence ID" value="XM_067202278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GJ09"/>
    <dbReference type="SMR" id="A0A836GJ09"/>
    <dbReference type="GeneID" id="92356212"/>
    <dbReference type="KEGG" id="loi:92356212"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032343902" description="Endochitinase" evidence="2">
        <location>
            <begin position="33"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5464748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="184" mass="19891" checksum="C5CE5D00127D32EA" modified="2021-09-29" version="1">MGTRGMTVFASGQLGLVHALLVIVVCSVGATAVVTEESSLSSPIVCTCRCCYQGGCSPLTNVSWTVSSCNDCSTKMCNDHIASEEVRAKTARLFEGIRGEKPLTDGTVEVQECEVIAVLEAATCTTKGCKRTSTIKAECYDRNAPLIKYSIISFVLLTIFAVIFGIIKNYIPAFQALNEKYFNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GJ48</accession>
    <name>A0A836GJ48_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mini-chromosome maintenance complex-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_04997</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062274.1">
        <property type="nucleotide sequence ID" value="XM_067206971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GJ48"/>
    <dbReference type="GeneID" id="92360905"/>
    <dbReference type="KEGG" id="loi:92360905"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019140">
        <property type="entry name" value="MCM_complex-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13489">
        <property type="entry name" value="MINI-CHROMOSOME MAINTENANCE COMPLEX-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13489:SF0">
        <property type="entry name" value="MINI-CHROMOSOME MAINTENANCE COMPLEX-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09739">
        <property type="entry name" value="MCM_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5476041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="597" mass="65887" checksum="6FFE952223A0751E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GJ91</accession>
    <name>A0A836GJ91_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_05057</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062334.1">
        <property type="nucleotide sequence ID" value="XM_067207031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GJ91"/>
    <dbReference type="SMR" id="A0A836GJ91"/>
    <dbReference type="GeneID" id="92360965"/>
    <dbReference type="KEGG" id="loi:92360965"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051847">
        <property type="entry name" value="RNA_proc/Spliceosome_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45880">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45880:SF1">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="24"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5476101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="158" mass="17950" checksum="A2550C2C544FD46D" modified="2021-09-29" version="1">MKKYRSGNSGPYTAEYHALLGSAPWIIIRRLLSQPRMDMGEDRNSPQLSEGDIVTVFSQFGEVVDVRFVRHRKTGRFLGTAFVKFKDYRSGILAADELNSNYEEGENFFLSASLEGSVSNSDQKGITVERCEEVVVPQLYNTEMETYAQWLSRHNVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GJJ7</accession>
    <name>A0A836GJJ7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">U-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061457.1">
        <property type="nucleotide sequence ID" value="XM_067205520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GJJ7"/>
    <dbReference type="SMR" id="A0A836GJJ7"/>
    <dbReference type="GeneID" id="92359454"/>
    <dbReference type="KEGG" id="loi:92359454"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16664">
        <property type="entry name" value="RING-Ubox_PUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045210">
        <property type="entry name" value="RING-Ubox_PUB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052608">
        <property type="entry name" value="U-box_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45958">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45958:SF18">
        <property type="entry name" value="U-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U-box" evidence="1">
        <location>
            <begin position="515"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5473454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="601" mass="66108" checksum="4809FBF6ED40F900" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GJL1</accession>
    <name>A0A836GJL1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosome assembly factor mrt4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_00500</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2 8">Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Ribosomal protein P0 is the functional equivalent of E.coli protein L10.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Associates with the pre-60S ribosomal particle.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">P0 forms a pentameric complex by interaction with dimers of P1 and P2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
            <location evidence="8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058679.1">
        <property type="nucleotide sequence ID" value="XM_067202578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GJL1"/>
    <dbReference type="SMR" id="A0A836GJL1"/>
    <dbReference type="GeneID" id="92356512"/>
    <dbReference type="KEGG" id="loi:92356512"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05796">
        <property type="entry name" value="Ribosomal_P0_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1730:FF:000005">
        <property type="entry name" value="Ribosome assembly factor mrt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.20:FF:000006">
        <property type="entry name" value="Ribosome assembly factor mrt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033867">
        <property type="entry name" value="Mrt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051742">
        <property type="entry name" value="Ribosome_Assembly_uL10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45841:SF1">
        <property type="entry name" value="MRNA TURNOVER PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45841">
        <property type="entry name" value="MRNA TURNOVER PROTEIN 4 MRTO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="9">
        <location>
            <begin position="126"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5465048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="227" mass="25347" checksum="3CAEA0A9DF90F24B" modified="2021-09-29" version="1">MPKSKRVRIVPLTKTQAKTRTDKDKLIERIREALEDYRDVYTFQLHNVRTNILQQIREERAGDSRIFLGNNKLMMIALGRDEESAQRENLHKLSPFLTGLCGLLFTNLSKKEVKDYFATVGAPVYARTGQTATESLVLKAGPLPQFPHSMFDHLAKLGLPIKLDRGVIVLLQETTVCEPGDTLSAEAAQLLKLFGVQSAEFKIELTAHWTNGVAKKVSSSASKKGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GJX6</accession>
    <name>A0A836GJX6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Rib72 protein-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_00682</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058859.1">
        <property type="nucleotide sequence ID" value="XM_067202758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GJX6"/>
    <dbReference type="SMR" id="A0A836GJX6"/>
    <dbReference type="GeneID" id="92356692"/>
    <dbReference type="KEGG" id="loi:92356692"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043014">
        <property type="term" value="F:alpha-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060285">
        <property type="term" value="P:cilium-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.170:FF:000009">
        <property type="entry name" value="EF-hand domain (C-terminal)-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.170:FF:000007">
        <property type="entry name" value="EF-Hand domain-Containing protein 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.170:FF:000010">
        <property type="entry name" value="Rib72_protein-like_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.170">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006602">
        <property type="entry name" value="DM10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040193">
        <property type="entry name" value="EFHC1/EFHC2/EFHB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12086">
        <property type="entry name" value="EF-HAND DOMAIN C-TERMINAL CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12086:SF9">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06565">
        <property type="entry name" value="DM10_dom"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00676">
        <property type="entry name" value="DM10"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51336">
        <property type="entry name" value="DM10"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0282">Flagellum</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DM10" evidence="10">
        <location>
            <begin position="83"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="DM10" evidence="10">
        <location>
            <begin position="249"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="DM10" evidence="10">
        <location>
            <begin position="422"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="576"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5465228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="741" mass="83696" checksum="96F216BF2F5B6DF4" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GKI5</accession>
    <name>A0A836GKI5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_04854</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000014">
        <property type="protein sequence ID" value="KAG5483702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064641.1">
        <property type="nucleotide sequence ID" value="XM_067206832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GKI5"/>
    <dbReference type="GeneID" id="92360766"/>
    <dbReference type="KEGG" id="loi:92360766"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="514"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="618"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="743"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="890"/>
            <end position="967"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5483702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="967" mass="108686" checksum="CC05AE9BDE846D4B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GNT7</accession>
    <name>A0A836GNT7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA (cytosine-5-)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_04472</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">LSCM4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="1"/>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062665.1">
        <property type="nucleotide sequence ID" value="XM_067206456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GNT7"/>
    <dbReference type="GeneID" id="92360390"/>
    <dbReference type="KEGG" id="loi:92360390"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044027">
        <property type="term" value="P:negative regulation of gene expression via chromosomal CpG island methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.120.10">
        <property type="entry name" value="DNA Methylase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050390">
        <property type="entry name" value="C5-Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031303">
        <property type="entry name" value="C5_meth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00675">
        <property type="entry name" value="dcm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10629">
        <property type="entry name" value="CYTOSINE-SPECIFIC METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10629:SF52">
        <property type="entry name" value="DNA (CYTOSINE-5)-METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00105">
        <property type="entry name" value="C5METTRFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00095">
        <property type="entry name" value="C5_MTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="408"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="638"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="738"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="738"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5477254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="844" mass="90545" checksum="8E29C128A72B46DE" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GQV4</accession>
    <name>A0A836GQV4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL23m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_04437</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">LSCM4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062630.1">
        <property type="nucleotide sequence ID" value="XM_067206421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GQV4"/>
    <dbReference type="SMR" id="A0A836GQV4"/>
    <dbReference type="GeneID" id="92360355"/>
    <dbReference type="KEGG" id="loi:92360355"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000852">
        <property type="entry name" value="Ribosomal protein L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_uL23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12059:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL23M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12059">
        <property type="entry name" value="RIBOSOMAL PROTEIN L23-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5477219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="254" mass="28896" checksum="D9AD49BD93FEBC29" modified="2021-09-29" version="1">MKRLGGRHAIVCGVVNPATAASSTRSCDIVGGGSSCTAASALVTARRGRFYRPLVNQGINLWRSRMGRLHKGWTTWEYNRDVVPDPRPFPEPAVNNYYGRSRIWNPIAGKIGIVNRKAEEWGWPHQRPPPTGLRRSPEYFPFFFSRYFPDVEVRLVLDSVLNNETTRPVFHIPQDMSKQELVNYLKNIYNIDNVVRISVRNMRGRRFKNEVGEIKSLPDYKVAVVELDSPVSIVFKQIKGTEDTPDNKPTAQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GRH9</accession>
    <name>A0A836GRH9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="8">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_01957</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="8">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="8"/>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061033.1">
        <property type="nucleotide sequence ID" value="XM_067203996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GRH9"/>
    <dbReference type="SMR" id="A0A836GRH9"/>
    <dbReference type="GeneID" id="92357930"/>
    <dbReference type="KEGG" id="loi:92357930"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07834">
        <property type="entry name" value="STKc_MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000972">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="32"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5472637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="410" mass="46410" checksum="F90BC5BC9B70734D" modified="2021-09-29" version="1">MMLTKVEGPNAAGNKVYVFGVNDYRLEVPERYNVQHFVGRGAYGFVCSAVDAVTNEPVAIKKVTHLFDDAVDAKRVLREVKLLAYFNHPNILSLKDLFKSPDPVDTYSELYVVTDLMESDMDAILRSPRIRLAAGHGQYFTLQLLCALQYTHSAHVLHRDLKPGNLLTDSECNLKLGDFGLARGIGHDDTMTQYVFTRWYRPPELLLVCKHCSYSADMWAVGCLAAEMFTGKPLFPGKDYINQINLIVELLGTPDLVRDLPPSASKEAVHYLSSLPPSKGKKLEEYAPELRRRFDEATFFDGFDTELEEAVAAEGAIIARPRPRPPEEYYAEFVDFIFGLLRYNPEKRRTAKESIAHAWLLDVRGPQEAIGGCEAEQVYRWDADGSTFSIPQLRQLFIDEIEKFASTRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GRJ9</accession>
    <name>A0A836GRJ9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_01989</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061063.1">
        <property type="nucleotide sequence ID" value="XM_067204026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GRJ9"/>
    <dbReference type="GeneID" id="92357960"/>
    <dbReference type="KEGG" id="loi:92357960"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000271">
        <property type="entry name" value="Pdz domain containing protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF209">
        <property type="entry name" value="PHOSPHOINOSITIDE PHOSPHOLIPASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="417"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5472667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="732" mass="80623" checksum="D4B588B005C9FF69" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GS97</accession>
    <name>A0A836GS97_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_07715</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000006">
        <property type="protein sequence ID" value="KAG5487227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065724.1">
        <property type="nucleotide sequence ID" value="XM_067209594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GS97"/>
    <dbReference type="SMR" id="A0A836GS97"/>
    <dbReference type="GeneID" id="92363528"/>
    <dbReference type="KEGG" id="loi:92363528"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF29">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3 4" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="7">
        <location>
            <begin position="45"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="119"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="602"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="672"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="544"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="392"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="192"/>
            <end position="199"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5487227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="718" mass="76310" checksum="DA5FF6529D23C816" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GTH1</accession>
    <name>A0A836GTH1_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_07568</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000004">
        <property type="protein sequence ID" value="KAG5487887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066084.1">
        <property type="nucleotide sequence ID" value="XM_067209452.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836GTH1"/>
    <dbReference type="GeneID" id="92363386"/>
    <dbReference type="KEGG" id="loi:92363386"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988:SF71">
        <property type="entry name" value="CITRON RHO-INTERACTING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="145"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="244"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="600"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1166"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1260"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1390"/>
            <end position="1463"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="325"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="518"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="809"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1004"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="173"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="250"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="620"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="651"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="701"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1349"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1390"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1425"/>
            <end position="1440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5487887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1463" mass="156762" checksum="12A29D3C15D2B2BF" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GTI6</accession>
    <name>A0A836GTI6_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060702.1">
        <property type="nucleotide sequence ID" value="XM_067205150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GTI6"/>
    <dbReference type="GeneID" id="92359084"/>
    <dbReference type="KEGG" id="loi:92359084"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040632">
        <property type="entry name" value="Sulfotransfer_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978:SF4">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOTIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17784">
        <property type="entry name" value="Sulfotransfer_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5471585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="385" mass="41778" checksum="3C40EB8398F24DEF" modified="2021-09-29" version="1">MLRSTSRVQLRVLCLTMLPDGGALTPALRKLGYTPYTLRSTYQQGHASTHPIEWSNLLDGKTNTLPAKVLADYDAVVGPPGAMVYDVLLRQAPSYTKVILVEETDKDRWAEEYDTYLERLQISTQRASKNRITRAFQNMIAKMVVGGEASGAAAASAAESALSPRAGKSGGHAMSSSANLRRSFAAKAAALQRGFCDSKAPIATSADDVGEDSRGASTAPLEREERANMASDGQLQRSRAVALQLYEESVKMSIPSTALLVYRYGDGWEPLCTFLGKPIPSIPFPEYENGLRVLGGLQERIERAHALQYLVGTVCVVCILVSVLPRCKGFVRFVKDLYADYQAAFGSDSAESAKQTVGGDDDTEAERFEAAWQKRGGYVTLTTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GUU3</accession>
    <name>A0A836GUU3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_00643</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058821.1">
        <property type="nucleotide sequence ID" value="XM_067202720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GUU3"/>
    <dbReference type="GeneID" id="92356654"/>
    <dbReference type="KEGG" id="loi:92356654"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009316">
        <property type="entry name" value="COG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024603">
        <property type="entry name" value="COG_complex_COG2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024602">
        <property type="entry name" value="COG_su2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 2"/>
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    </dbReference>
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        <property type="entry name" value="COG2_C"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="80"/>
            <end position="200"/>
        </location>
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        <location>
            <begin position="575"/>
            <end position="927"/>
        </location>
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        <location>
            <begin position="1"/>
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            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
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        <location>
            <begin position="667"/>
            <end position="688"/>
        </location>
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        <location>
            <begin position="871"/>
            <end position="908"/>
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        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007603"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020977"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00031344"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF06148"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF12022"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5465190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="976" mass="105399" checksum="5467E2E6729A47A7" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GV69</accession>
    <name>A0A836GV69_9TRYP</name>
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            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
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        <name evidence="3" type="ORF">LSCM4_07000</name>
    </gene>
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        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
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            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
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    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000017">
        <property type="protein sequence ID" value="KAG5481921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="loi:92362841"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="20"/>
            <end position="41"/>
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        <location>
            <begin position="57"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
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        <location>
            <begin position="170"/>
            <end position="207"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5481921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="232" mass="24170" checksum="6734D82061121931" modified="2021-09-29" version="1">MDFLQVVDPVTLMPVSYTHLALELAMSVACTVLLGVCLHVLPERLVRRSKAARVKVPREAVAEVATPASRPAVPMESPTLASPAPSSSATAPKNTDPAPSPAIAESTLDGALESFFEEESLLDEALLDTAVPSAPPGEEAPPAGSTRVKVAQPSTNEAVEFSRELAAKMTKGLQSKARPAAVAPPPEAASGSPAKNETAEKQLEDALDAYMAEEELLNEAMLDSTVAAAHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GVB0</accession>
    <name>A0A836GVB0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Endonuclease V</fullName>
        </recommendedName>
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        <name evidence="7" type="ORF">LSCM4_00244</name>
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    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
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        <lineage>
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            <taxon>Discoba</taxon>
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            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067202333.1"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A836GVB0"/>
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    <dbReference type="KEGG" id="loi:92356267"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016891">
        <property type="term" value="F:RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="archaeoglobus fulgidus dsm 4304 superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Endonuclease-V"/>
    </dbReference>
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        <property type="entry name" value="ENDONUCLEASE V"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Endonuclease_5"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
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        <location>
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            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5464803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="397" mass="43338" checksum="D0992C66D1D27E1B" modified="2021-09-29" version="1">MRPTPVSPVQKQKHQQRPPSIGVWHCSEKKRAWEEEQLRIALLADVPRTECYYCPHLSGQGSSEVQSTAPHRESAAPDEEFVHRRFALPDFESRLLAHPQPGAGDSTEARGADSAKCGFSSLHSPWEALRRQLQFDKVQQSAAAASNSAVAPQLPALTFVGGVDISFIPGTDDGVACLAILRYPSMELVKTYMHRCTLREPYICGFLAFREIQPVCELFDSVRVELLVTCTMPQLLIVDGNGIQHPRRCGLATHLGVVLDIPTIGCSKKLLQVDGLTREAVEAALEASVEAESRSSPLPRLLPLLGTSMPRQLYGYAVQGQRNSVKKCIYVSPGHCVGFAVAAALVLTMLRHRIPEPIRAADLSSRAYISSILEPAVAAVPYSLPHAPTPRTVNDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GW00</accession>
    <name>A0A836GW00_9TRYP</name>
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        <recommendedName>
            <fullName evidence="9">Fucose kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_05579</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Euglenozoa</taxon>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000016">
        <property type="protein sequence ID" value="KAG5482326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064332.1">
        <property type="nucleotide sequence ID" value="XM_067207518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GW00"/>
    <dbReference type="SMR" id="A0A836GW00"/>
    <dbReference type="GeneID" id="92361452"/>
    <dbReference type="KEGG" id="loi:92361452"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050201">
        <property type="term" value="F:fucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042352">
        <property type="term" value="P:GDP-L-fucose salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012887">
        <property type="entry name" value="GDP_fucose_pyrophosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052203">
        <property type="entry name" value="GHMP_Kinase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001174">
        <property type="entry name" value="HddA/FKP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32463">
        <property type="entry name" value="L-FUCOSE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32463:SF0">
        <property type="entry name" value="L-FUCOSE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07959">
        <property type="entry name" value="Fucose_pyrophosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00960">
        <property type="entry name" value="LMBPPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GDP-fucose pyrophosphorylase" evidence="6">
        <location>
            <begin position="99"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="5">
        <location>
            <begin position="947"/>
            <end position="1023"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5482326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1205" mass="129730" checksum="47D017E53BB1B3F9" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GW23</accession>
    <name>A0A836GW23_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_01263</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059011.1">
        <property type="nucleotide sequence ID" value="XM_067203320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GW23"/>
    <dbReference type="GeneID" id="92357254"/>
    <dbReference type="KEGG" id="loi:92357254"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5466121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="161" mass="17562" checksum="81216F006931D8B4" modified="2021-09-29" version="1">MFSSRKTPAKAQGDGYDDEQHLVAAVSEFKKVEASNQTMVDQLHQRLASPFQITAKPCEASRLAVLQCYQQLQGSPAATNSDAAALTPPGTWSDSKSVHPVPDGAWLSIPYQRCYETALAYHQCVEDTLAKHLGLVAAFEQRGAQQKIMQQAVGKAQEESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GWA8</accession>
    <name>A0A836GWA8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Xaa-Pro dipeptidase</fullName>
            <ecNumber evidence="10">3.4.13.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Imidodipeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Peptidase D</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Proline dipeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">LSCM4_01417</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>Xaa-L-Pro dipeptide + H2O = an L-alpha-amino acid + L-proline</text>
            <dbReference type="Rhea" id="RHEA:76407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:195196"/>
            <dbReference type="EC" id="3.4.13.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase M24B family. Eukaryotic-type prolidase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.9" evidence="10"/>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059161.1">
        <property type="nucleotide sequence ID" value="XM_067203470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GWA8"/>
    <dbReference type="SMR" id="A0A836GWA8"/>
    <dbReference type="GeneID" id="92357404"/>
    <dbReference type="KEGG" id="loi:92357404"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102009">
        <property type="term" value="F:proline dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01087">
        <property type="entry name" value="Prolidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.350.10:FF:000035">
        <property type="entry name" value="Aminopeptidase P, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000002">
        <property type="entry name" value="Xaa-Pro aminopeptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48480:SF2">
        <property type="entry name" value="PEPTIDASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase P N-terminal" evidence="17">
        <location>
            <begin position="14"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG5466271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="484" mass="53811" checksum="138BC5B3E2237C5A" modified="2021-09-29" version="1">MSAHDKSLAYPFPISMRMYREQRERLAASLQQAFPKGGHAAVLQAASEVPVNSTDCNYLFVQESYFYYLFGAEMPDAYGAVLANGKGIMFIPRLPADYATWMGPLPTLLGVKAELEMDEVHYVDEMEEVLTSHGVHTAEVLKGTNTDSGLEVLQARLPEGTRLRKSTDFLYCTLSSQRCYKTALEADVLRYVCKVSSEAHIKVMQIAKPGMSQHHLESTFLHDVYYNGGCRRVSYTCICATGCHGATLHYPDNNCAIEDGTMALLDMGGNYRGYAADITCSFPVNGKFTEAQKVIYNAVLDAHDKVMHTVKPGVLWLDMHLLAIRTICTHLVAAGILKGDVDTLMAKEIMQYFQPHGLGHLIGMDVHDVGGYMKGCPERPAKKDCCRLRTARTIEEGLYMTIEPGCYFNAALIEMAKANPEVKEHLNLEKIEEYAHFGGVRIESDVLVTKDGLVNYTLVPRTVEEIESTMTGAPFAKEVEVYHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GXJ6</accession>
    <name>A0A836GXJ6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_03136</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060705.1">
        <property type="nucleotide sequence ID" value="XM_067205153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GXJ6"/>
    <dbReference type="SMR" id="A0A836GXJ6"/>
    <dbReference type="GeneID" id="92359087"/>
    <dbReference type="KEGG" id="loi:92359087"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052423">
        <property type="entry name" value="EMIR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44094">
        <property type="entry name" value="DNAJ HEAT SHOCK N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44094:SF8">
        <property type="entry name" value="DNAJ HEAT SHOCK N-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032649671" description="J domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="288"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="586"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5471588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="605" mass="64137" checksum="CFD059F43F652D0F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GY44</accession>
    <name>A0A836GY44_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000016">
        <property type="protein sequence ID" value="KAG5482294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064300.1">
        <property type="nucleotide sequence ID" value="XM_067207486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GY44"/>
    <dbReference type="GeneID" id="92361420"/>
    <dbReference type="KEGG" id="loi:92361420"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5482294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="219" mass="24017" checksum="4B0ECFA965442469" modified="2021-09-29" version="1">MPLKQQEEVCGKPNQYNLKTLEYDWKELPNTHFQIPPQQPRVRDASALGGHDAAGRRLNPITHQPLPFPGCGPRSSRAVSPTPLPSPSRPAQEGMRLQPSPQLHSGNRDHVAELLSGGGGSARLTPSHEPQHRARAPLFVEEDSPQIPRDRYPPSGACQQVPLFPYASVFGGDGTPQRNAPAAPSQASDADAFNFAWSHEDMRRVGQTNSVEAQRSYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H0E5</accession>
    <name>A0A836H0E5_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_04369</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062563.1">
        <property type="nucleotide sequence ID" value="XM_067206354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H0E5"/>
    <dbReference type="GeneID" id="92360288"/>
    <dbReference type="KEGG" id="loi:92360288"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="259"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="574"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="102"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5477152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="655" mass="71233" checksum="64F7DF494AEAC016" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H1C3</accession>
    <name>A0A836H1C3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">60S ribosomal protein L13a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_07189</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000015">
        <property type="protein sequence ID" value="KAG5482979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064475.1">
        <property type="nucleotide sequence ID" value="XM_067209092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H1C3"/>
    <dbReference type="SMR" id="A0A836H1C3"/>
    <dbReference type="GeneID" id="92363026"/>
    <dbReference type="KEGG" id="loi:92363026"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1180.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_uL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005755">
        <property type="entry name" value="Ribosomal_uL13_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01077">
        <property type="entry name" value="L13_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5482979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="25449" checksum="2B140EEAABA09449" modified="2021-09-29" version="1">MAFPSRKDASRAQRKGAKKHRPEIIVIDLKDHVLGRAAAVVAKQLLLGKKITVVRCEQLNIAGTEIRNKIKYLQYLRKRKLTNPTKGPFHHRSPSDVFIRTVRSMLPRYTKRGMKALNSLVAYEGVPANVVRTGGRVVIPRAQRHACYRPERPYTVLGNMCKHVGWKYSDVVAKLEQARVEKASRHHKKQEKLRDAWMTARKEALAKMPKHNVEVLKKFGYA</sequence>
</entry>
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                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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        </source>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5473575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="367" mass="38917" checksum="3734C077741F3E76" modified="2021-09-29" version="1">MPVYCTSRRTAATARRFWGPSSLSALNGSSALAHSPRLVCTAEVDRHCASSGLTTAVGVDASFEACPVRSSSEGNRVNSNPKRFGGTATGLSHPQRSPTVRVFSKPAHQLTAAQLAHFTHLRGLLCRLSGIRPRSSEAVRSALRAEEAYHQLPREAKLTSQSLQPRALTKVGQALHSELYVMSRVIASPHHHSLLAEGDAAACDGTVFTGVNHAFHKRVNLPGATLRGILKGCAEQNALGAAAASGCIYADVADVFLLAARSLHTRFDRALEPAKGIDGPASAPCNSCATLGSNAGPSAAQAVATFPCPECWRHLCHVARARLQHERPPLRLFVYAASPVANIQLFTVAQQRAKTMEAPMDVCIVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HBP9</accession>
    <name>A0A836HBP9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RanBP-type and C3HC4-type zinc finger-containing protein 1</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LSCM4_03937</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061867.1">
        <property type="nucleotide sequence ID" value="XM_067205930.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92359864"/>
    <dbReference type="KEGG" id="loi:92359864"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF22">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="555"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="1004"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="1110"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="150"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="349"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="939"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1062"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1285"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="172"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="317"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="349"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="367"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="1068"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1293"/>
            <end position="1309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG5474761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1309" mass="140550" checksum="8A7A29CBC83AFAB5" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HCU3</accession>
    <name>A0A836HCU3_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_06860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000017">
        <property type="protein sequence ID" value="KAG5481785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064145.1">
        <property type="nucleotide sequence ID" value="XM_067208771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HCU3"/>
    <dbReference type="SMR" id="A0A836HCU3"/>
    <dbReference type="GeneID" id="92362705"/>
    <dbReference type="KEGG" id="loi:92362705"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010564">
        <property type="term" value="P:regulation of cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039893">
        <property type="entry name" value="CEP120-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21574">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 120 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21574:SF0">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 120 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="372"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="157"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="372"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5481785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="500" mass="54426" checksum="15348B6054CFFE63" modified="2021-09-29" version="1">MSGGSKSGSDGSRRASSGMMGGSSDRSRGSDDESRGAGVQRRGSLHQALLPRGGYHGSTASTLTLPQPREPSVTVTGRSSSPSDTPFEKGNAAVASGVKSASGATAARFILPDSTPSLSAESSTPAAAAAYDVRDTAEYRAAWDLELWKAVQADRFRKALEKQRSAALADLKRLVKRREKEARVELQQRTTAVALREKAVQAEEARLAERQQRVADMEKDLRRMRQQLLDAQQRVEDEVRAQVRLANDTIAHRARLLEERVKGAEAQARRADERQRQAQQEYVSLYEAFSRYRTQQLTSAHSVSGGGTCATAGGETASAALQMEQLRVQWEAEHQLKLDRQAQQHAADMAAAQQRCRDLEEQNRRLAAALARRREQLRRHAEDALQPSPPTSAPQRWPPQAVCEGREGLVGSGAAASPFSTPSPTVGASTTAALPSLHNTAVLCDFVERASRELHRLETERSSLVEGSSGALRETDIVIVRIDARIRELREQLSAVTSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HDX8</accession>
    <name>A0A836HDX8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Outer arm dynein-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_07949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000013">
        <property type="protein sequence ID" value="KAG5484382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064875.1">
        <property type="nucleotide sequence ID" value="XM_067209825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HDX8"/>
    <dbReference type="SMR" id="A0A836HDX8"/>
    <dbReference type="GeneID" id="92363759"/>
    <dbReference type="KEGG" id="loi:92363759"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21455">
        <property type="entry name" value="DLC-like_DYNLT1_DYNLT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.40">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005334">
        <property type="entry name" value="Tctex-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038586">
        <property type="entry name" value="Tctex-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255:SF41">
        <property type="entry name" value="LIGHT CHAIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255">
        <property type="entry name" value="T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03645">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5484382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="118" mass="13423" checksum="BF6B2788A76FB23C" modified="2021-09-29" version="1">MADYEPEGNLEQNSTLSSEGIQEDISNLLRTRLAGEQWNPTKVDGWVEDIVNSILSELAELKKPYKYIVTCMFMQRTGAALSVGFISLWDNTKDGMVHVPFENDSFHCLVTLYFLKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HDZ0</accession>
    <name>A0A836HDZ0_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000016">
        <property type="protein sequence ID" value="KAG5482370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064376.1">
        <property type="nucleotide sequence ID" value="XM_067207562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HDZ0"/>
    <dbReference type="GeneID" id="92361496"/>
    <dbReference type="KEGG" id="loi:92361496"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5482370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="297" mass="32125" checksum="0D5E71ED9C905E1E" modified="2021-09-29" version="1">MPQDMGPQAAPLFRAGGRRSCDVFPSASKRRNPFIVVLGSSCGVQRAADDTVFPFMGGLAPSACPRGKSLLAAPVHRHPFFARSLGPQRPGGQRCCGSRRSSGCTPLSQLLSEEQVTRWMLRCEEQEERVDIALAKPSCRVLLSHAHSTLGFSSREQDDERLGYGSHSRPHLPPSEPVRPTADKTHPGRTGGRRTKTKRQCSSTRSGGLHEQPSSEAQDTASAPTLLYVRDSELLRALQRAEARIKELEASTAPEAPGSGGEENLNVSSSTMPNPQAPARPGTIHPYIPLSPRLEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HF69</accession>
    <name>A0A836HF69_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PUM-HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_04320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062243.1">
        <property type="nucleotide sequence ID" value="XM_067206306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HF69"/>
    <dbReference type="SMR" id="A0A836HF69"/>
    <dbReference type="GeneID" id="92360240"/>
    <dbReference type="KEGG" id="loi:92360240"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5475735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="385" mass="41515" checksum="8CFF0EA5A3E6227A" modified="2021-09-29" version="1">MRSEVTLSIDARKWAETIEAAGANCLLSAVSAKNVTHVLSTATVRAPQKQLCAAVSNVVPAMLENAHGVSILTALVRYGTTATVEQVASKLTESDGGVWSFADAPKKELTKCLSQLLERLVYREDCHGESYKALISRLKATKKQSLMTSSFTLPAAARLALVDDTFAAALLSSSEAQKSLAKSCQNASTTDAAEEFCRILFERSADDRAGNFVWKALAASMKANAKAHPREAILALLAAHAPVPLVNKMTNAMAQWPTVRDLCVRDSYAHIVAYMLERCDDEKAGNELVAAVIKQETDVTERMSARKSAQHHLLAVLSAKPSYGQTLEKCLGASQSKRLAAARVRFANATQPKAITTQQAILDKLKKLHSTTSSSFGAGVKRLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HJK3</accession>
    <name>A0A836HJK3_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5478000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062907.1">
        <property type="nucleotide sequence ID" value="XM_067207339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HJK3"/>
    <dbReference type="GeneID" id="92361273"/>
    <dbReference type="KEGG" id="loi:92361273"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5478000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="242" mass="24918" checksum="788D4F69780A1786" modified="2021-09-29" version="1">MPPRAARISIRDSVSVAVRKHLCTAAAAAGVVTATKGESARASTTATPALETVAPALSPSSSRVSRRRRDVVPQATPEWQRMALNTAAAARPDKRRGGGAGAKTGGSSATAVAVSRKSPAVTAKNMKSNGRHKHAEKERAKAEGHEDEAAATVASPLHAESDANSSSGGKHAKPRRGKAGKAAAAPTAKRGKRVPVAELLCPRCRLRIDQWPYCGLSGEAHELRAPRSVAKEEDGAAAAAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HK16</accession>
    <name>A0A836HK16_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_05477</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5478078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062985.1">
        <property type="nucleotide sequence ID" value="XM_067207417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HK16"/>
    <dbReference type="SMR" id="A0A836HK16"/>
    <dbReference type="GeneID" id="92361351"/>
    <dbReference type="KEGG" id="loi:92361351"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032435401" evidence="2">
        <location>
            <begin position="27"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5478078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="244" mass="28950" checksum="E5218ADA8A33A7D3" modified="2021-09-29" version="1">MRPAPLRCSAAAVRFTALLLHGSTSGNGGGYRFFEDMYPKHDPAPRYSCYEEQMQSPTVRSLEPKKQMTETEKLHYLHDWKRDKEGLAPPPEFGWPEEWGPEPGEEGHSEWYKKNRMYMSYEEKSKYDLRVGVPVEKNSMRHQEMPYQKRMKAAYVNLEEKNPQYFDPRQRKYWAEYSYEDQRDTMAKARDDYIKEWLDEPGVTKENVAKKIGDYNGTAKNQNVKSVQRRPEWELAPRPEYDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HL06</accession>
    <name>A0A836HL06_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Calcium uniporter protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">LSCM4_05914</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCU (TC 1.A.77) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063617.1">
        <property type="nucleotide sequence ID" value="XM_067207844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HL06"/>
    <dbReference type="SMR" id="A0A836HL06"/>
    <dbReference type="GeneID" id="92361778"/>
    <dbReference type="KEGG" id="loi:92361778"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990246">
        <property type="term" value="C:uniplex complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015292">
        <property type="term" value="F:uniporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036444">
        <property type="term" value="P:calcium import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051560">
        <property type="term" value="P:mitochondrial calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006769">
        <property type="entry name" value="MCU_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039055">
        <property type="entry name" value="MCU_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13462">
        <property type="entry name" value="CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13462:SF10">
        <property type="entry name" value="CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04678">
        <property type="entry name" value="MCU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium uniporter protein C-terminal" evidence="16">
        <location>
            <begin position="49"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG5479906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="251" mass="28288" checksum="B8398F4F0C707A5B" modified="2021-09-29" version="1">MMTETFLRKALFARSAIDLCGRKILPKDAFVMLLTQGYRTPSRFRMTDAEAVKYVDALKRANMIVEVDDYVYTDVKAVIDAVHLKSGLPLVSVTSERVVNLYHTLSESLNAFNREASPAVERAVRLEKEFWAFTALGSGTQMLVLAYLTFQVYGWDVMEPVTFFVTTATALCAYAYFLYFRTEPSYESVDDKFLPYLLVKELGVLRADAEKAIRDMKAAQELQSVIALDDERVSKMVETAVKNKSACSCPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HMC6</accession>
    <name>A0A836HMC6_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000022">
        <property type="protein sequence ID" value="KAG5479263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063356.1">
        <property type="nucleotide sequence ID" value="XM_067203897.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836HMC6"/>
    <dbReference type="GeneID" id="92357831"/>
    <dbReference type="KEGG" id="loi:92357831"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="677"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="788"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1094"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1244"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1542"/>
            <end position="1658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1731"/>
            <end position="1759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1866"/>
            <end position="1888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1927"/>
            <end position="1947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2173"/>
            <end position="2204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="429"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="528"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="548"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="680"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="691"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1251"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1565"/>
            <end position="1577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1590"/>
            <end position="1601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1649"/>
            <end position="1658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2173"/>
            <end position="2194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5479263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="2326" mass="243983" checksum="6235F058EABBCF1A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HNU0</accession>
    <name>A0A836HNU0_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_08020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000005">
        <property type="protein sequence ID" value="KAG5487575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065863.1">
        <property type="nucleotide sequence ID" value="XM_067209896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HNU0"/>
    <dbReference type="SMR" id="A0A836HNU0"/>
    <dbReference type="GeneID" id="92363830"/>
    <dbReference type="KEGG" id="loi:92363830"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="121"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="500"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="20"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5487575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="531" mass="58219" checksum="1B1CDB40AF81E3B6" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HPA0</accession>
    <name>A0A836HPA0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000020">
        <property type="protein sequence ID" value="KAG5480445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063776.1">
        <property type="nucleotide sequence ID" value="XM_067208136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HPA0"/>
    <dbReference type="GeneID" id="92362070"/>
    <dbReference type="KEGG" id="loi:92362070"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5480445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="23617" checksum="9FC25FB93A290B25" modified="2021-09-29" version="1">MANCAFGRVPQPLHRVGRRCRGQRNISATFRTSCLALWRRPSTRSASGAVVLCFAVVFHRSSSGSPSCSQWALMTRCDPMLVFHSVSPPSSRLHLGIDDVSTRSLSYDFSERQEHLFLLTFPPLPSNHRLALIAAYSFPFLSSLVLLFSFPLSLLPLLLCILFGILRSCFLLYYALFSLVSGDITARTPTRVSFSPLCVRANACVDGLLPLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HPY9</accession>
    <name>A0A836HPY9_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_08312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000001">
        <property type="protein sequence ID" value="KAG5488235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066282.1">
        <property type="nucleotide sequence ID" value="XM_067210181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HPY9"/>
    <dbReference type="GeneID" id="92364115"/>
    <dbReference type="KEGG" id="loi:92364115"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5488235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="116" mass="13602" checksum="C82DDE213DA855FD" modified="2021-09-29" version="1">MALPGVSHYERMPTRTKIQFFWISMLTMGFAYQFLKMTVLRVQPKREEQMYLHIRKVYGDNIPEELLQIAKRQREAQDALTLTNMLRTPTPGQTSNALQNDLDPRALVNLKSWNGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HSX1</accession>
    <name>A0A836HSX1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 16">Dihydroorotate dehydrogenase (fumarate)</fullName>
            <ecNumber evidence="7 16">1.3.98.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14 16">Dihydroorotate oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">LSCM4_05588</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor. Molecular oxygen can replace fumarate in vitro.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>(S)-dihydroorotate + fumarate = orotate + succinate</text>
            <dbReference type="Rhea" id="RHEA:30059"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="EC" id="1.3.98.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 16">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 16">Pyrimidine metabolism; UMP biosynthesis via de novo pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 16">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 16">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 16">Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.98.1" evidence="7 16"/>
    <dbReference type="EMBL" id="JAFHLR010000016">
        <property type="protein sequence ID" value="KAG5482335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064341.1">
        <property type="nucleotide sequence ID" value="XM_067207527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HSX1"/>
    <dbReference type="SMR" id="A0A836HSX1"/>
    <dbReference type="GeneID" id="92361461"/>
    <dbReference type="KEGG" id="loi:92361461"/>
    <dbReference type="UniPathway" id="UPA00070"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990663">
        <property type="term" value="F:dihydroorotate dehydrogenase (fumarate) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04741">
        <property type="entry name" value="DHOD_1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000027">
        <property type="entry name" value="Dihydropyrimidine dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050074">
        <property type="entry name" value="DHO_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033886">
        <property type="entry name" value="DHOD_1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012135">
        <property type="entry name" value="Dihydroorotate_DH_1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH_cat"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002702">
        <property type="entry name" value="PRK02506.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109:SF1">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (FUMARATE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000164">
        <property type="entry name" value="DHO_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11 16" id="KW-0288">FMN</keyword>
    <keyword evidence="13 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12 16" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroorotate dehydrogenase catalytic" evidence="17">
        <location>
            <begin position="3"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00021374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00058668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU364042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG5482335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="313" mass="33847" checksum="ADA777F7364B33C8" modified="2021-09-29" version="1">MSLQLTILGNTFANPFMNAAGVMCSTTDDLVAMTKSTSGSLVSKSCTPALREGNPAPRYQTLPLGSINSMGLPNKGFDYYLTYASEQHDYSRKPLFLSMSGFSAEENAAMCSRLAAVAAEKGVLLELNLSCPNVPGKPQVAYDFDAMRRYLTAVSEAYPHPFGVKMPPYFDFAHFDTAAAILNEFPQVQFITCINSVGNGLVIDVDTESVVIKPKQGFGGLGGRYVLPTALANINAFYRRCPRKLIFGCGGVYTGEDAFLHVLAGASMVQVGTALQEEGAAIFDRLTAELLELMAKKGYTTLDEFRGKVKTME</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HT34</accession>
    <name>A0A836HT34_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000016">
        <property type="protein sequence ID" value="KAG5482425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064431.1">
        <property type="nucleotide sequence ID" value="XM_067207617.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92361551"/>
    <dbReference type="KEGG" id="loi:92361551"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="669"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1044"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1440"/>
            <end position="1463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1667"/>
            <end position="1696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="680"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1681"/>
            <end position="1694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5482425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1878" mass="200697" checksum="7544AD9EC1E0E9DD" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HWW5</accession>
    <name>A0A836HWW5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Actin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_07927</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">LSCM4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000013">
        <property type="protein sequence ID" value="KAG5484360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064853.1">
        <property type="nucleotide sequence ID" value="XM_067209803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HWW5"/>
    <dbReference type="SMR" id="A0A836HWW5"/>
    <dbReference type="GeneID" id="92363737"/>
    <dbReference type="KEGG" id="loi:92363737"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000148">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000366">
        <property type="entry name" value="Putative actin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5484360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="483" mass="52317" checksum="7196DBAD28220C9E" modified="2021-09-29" version="1">MDYNVSNAVVVLDCGSFHSRAGFGGEKGPRLDVPTLVGYPRHRGIAMAAGMNEQEVGEEALLKQGIFDVHHPIRDGFIDDWGDVEKLWSHLFFNELRVSPETHCFLLTQPVNTPTAQRERTLEIMMETFHAHSLYLGTSQVLSLYSYGLTTGVVVDSGKDVTRAVPIHEGYALVRHVTQSPVAGAALTRYLGGLLRVQGYALGTATEQELLNRAKEDLCYVQPSAHAHREAVGDILMPSSEASAAASPVNASALSCRSTQPSAGGKGSVASASLGTTATTATAKGAISGSCAGYCFDGDGESMLVTAAEATEDFVLPDGQRIPLTAERHETAEVLFNYSLLAMMDSNGTDTSTYEPRCKVRTDMGDIFRPSFEKGLSWLPFAAVNNCEAALRPQLYANMVLAGGSTSFPGLKTRLKSEVRQLYRESHPSEAVVPIQVRDMVCRAYSAWLGGSMLAQTAVFRHLVVSRREYEEEGARVIHYKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836I4L1</accession>
    <name>A0A836I4L1_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_07539</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000004">
        <property type="protein sequence ID" value="KAG5487858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066055.1">
        <property type="nucleotide sequence ID" value="XM_067209423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836I4L1"/>
    <dbReference type="GeneID" id="92363357"/>
    <dbReference type="KEGG" id="loi:92363357"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5487858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="305" mass="33832" checksum="0977FE5BCB853F10" modified="2021-09-29" version="1">MNPYYGKARKPYVPIDTCSPGGTWVEERRYNRMRPTVTGTAAASAEAAADGASSRIAENWTAADRRPRRVLCGNWQEDDVLERDLLAIQEAQRQEQHSGAESAPLTSSSAPVRRIQAFLTAGWAPTATTKVITQKPNGLYTGGHTSTPYLTCDSRNPTMRDLNSTYRVDFNSTSSDVSSLRRPDLGVRSQRLLEQVRVAAKEMQAANARARQEQLLLHEASMKGMSRSQGPNVSEYRATMCDENEVLPVVEELSQDYLSDEPITLYTGNPYTGKTMTVHGKTPADPASSSRFGKHTHFTEFKYAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836K6I8</accession>
    <name>A0A836K6I8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Guanine nucleotide-binding protein subunit beta-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_00392</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058575.1">
        <property type="nucleotide sequence ID" value="XM_067202474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836K6I8"/>
    <dbReference type="SMR" id="A0A836K6I8"/>
    <dbReference type="GeneID" id="92356408"/>
    <dbReference type="KEGG" id="loi:92356408"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF0">
        <property type="entry name" value="NOTCHLESS PROTEIN HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="125"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5464944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="393" mass="42911" checksum="6742F64517863C7B" modified="2021-09-29" version="1">MQEIIDTVNRYTLRSAAFRDKPTPGFATRQFLCSLLLHRQLDFIRLSSIAHYMFSTEALIAVSRDGIQTISCEGDALWPICTIPNESTSEISGVAVTPEGTLVCSSNGIRYIEGGNPRVTEDHVSSSYAQNVLCISCTPDGKYIATGGGTATVSVWTSDLKPLHHFAGHTDWVRFVKFARGRSPALQLFSTGDDGVICQWDVLAGSLISRVDYSLGESIQLFEVSYYSGLIAISSGTSLIALYCPRSDNTTRAVGEDVLRLQQMALISGVHDYTPTAGKFTDDSQWLASASEDETIALTYVLNPQTCFVCKEFVTRRRCFSFMSIFNSICILAAPPVSSVIVIAACSSDGTVVQWVVDPRTSRTSYTKKLQLHLGSFLGMDLIPGDGLNSLLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836K915</accession>
    <name>A0A836K915_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UmuC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_00009</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058202.1">
        <property type="nucleotide sequence ID" value="XM_067202101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836K915"/>
    <dbReference type="SMR" id="A0A836K915"/>
    <dbReference type="GeneID" id="92356035"/>
    <dbReference type="KEGG" id="loi:92356035"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017125">
        <property type="term" value="F:deoxycytidyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01701">
        <property type="entry name" value="PolY_Rev1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.60:FF:000016">
        <property type="entry name" value="DNA damage repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053848">
        <property type="entry name" value="IMS_HHH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21999">
        <property type="entry name" value="IMS_HHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UmuC" evidence="2">
        <location>
            <begin position="56"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5464571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="616" mass="68876" checksum="4CD7D6E7F19AD419" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836K9A9</accession>
    <name>A0A836K9A9_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5468049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059851.1">
        <property type="nucleotide sequence ID" value="XM_067203201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836K9A9"/>
    <dbReference type="GeneID" id="92357135"/>
    <dbReference type="KEGG" id="loi:92357135"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5468049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="416" mass="46437" checksum="BFF5FD909D04D0BD" modified="2021-09-29" version="1">MWYGQRQLGSFLRRWAKSSALWIAVAPHRLSSTTSLTSSATVAPVNLSYTCHLLDSICREPQADPVKRKRVRGAVRQMESSIVDSFAATTMSLTPPQRLDLMRHWLRSLAAAVRYLSRLEDSPRTPENAEGDRFSPRSSRRARHDPHEGDTWSGASPYFSLSTGDLLCACLRECAIGDPNAGPEGLRELLLCAVKLELGELEVLQHIVHVLTKTDACRHQTPSEQVELLNNVSLAVKRCKLPVPPLDLVLCGVLRTMLSARENLLVLSSIHRLKHRQAADVVAIVSRRAAKQTGEYNFKDVVYALEVAALLPGCNEVFVAGVLTRAGTLAPRMSPKQLGVVCKYVALLNPSRRQNTVAYSCGKELRALMPLLVERAERLLGQFRLHEARYVLRCFREHKVRHSLIFSRLTPIAEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KA70</accession>
    <name>A0A836KA70_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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                <person name="Bates M.D."/>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062442.1">
        <property type="nucleotide sequence ID" value="XM_067207139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KHI0"/>
    <dbReference type="GeneID" id="92361073"/>
    <dbReference type="KEGG" id="loi:92361073"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000110">
        <property type="entry name" value="Zinc finger protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050888">
        <property type="entry name" value="ZnF_C2H2-type_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24406">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="23"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="58"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="200"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="282"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="597"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="224"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="282"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="294"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5476209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="625" mass="67814" checksum="AC5ECC7D583F0B9D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KHW0</accession>
    <name>A0A836KHW0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">IQCH-like ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_03455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061395.1">
        <property type="nucleotide sequence ID" value="XM_067205458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KHW0"/>
    <dbReference type="GeneID" id="92359392"/>
    <dbReference type="KEGG" id="loi:92359392"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056855">
        <property type="entry name" value="ATP-grasp_IQCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038752">
        <property type="entry name" value="IQCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14465">
        <property type="entry name" value="IQ DOMAIN-CONTAINING PROTEIN H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14465:SF0">
        <property type="entry name" value="IQ DOMAIN-CONTAINING PROTEIN H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24923">
        <property type="entry name" value="ATP-grasp_IQCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IQCH-like ATP-grasp" evidence="2">
        <location>
            <begin position="515"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5473392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="900" mass="99617" checksum="5AEA87F9AF805DC1" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KK73</accession>
    <name>A0A836KK73_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_04539</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062732.1">
        <property type="nucleotide sequence ID" value="XM_067206523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KK73"/>
    <dbReference type="SMR" id="A0A836KK73"/>
    <dbReference type="GeneID" id="92360457"/>
    <dbReference type="KEGG" id="loi:92360457"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5477321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="282" mass="32718" checksum="945C0B100175CAC6" modified="2021-09-29" version="1">MRATSDEIFRAPESGEKELVDSIRNRRKKFELYQSESHKMKSLMMNSAGVRSDLVTANGRALNPIWMSFPEKCVRSITSVAEMKEKLNYFSKADDVMVVRYHQNNCTACNAVGKVFEMLCHQAATRTPGLKFYDVNRSDVPELAKGLVRFPQIKGYSGGQWIDIDFKPPTAFREELYAAIEKEVKRLKNQGKPVTALQAEEMYFSGAGPAMLEITEEQLMKFYCKAQVRLHNYWKQVSMRRSWFYRKFIEPEVDERVMNEWRGRSVFGEKLLYGPQLPEEFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KKQ7</accession>
    <name>A0A836KKQ7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosducin thioredoxin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosducin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5477906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062813.1">
        <property type="nucleotide sequence ID" value="XM_067207245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KKQ7"/>
    <dbReference type="SMR" id="A0A836KKQ7"/>
    <dbReference type="GeneID" id="92361179"/>
    <dbReference type="KEGG" id="loi:92361179"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051498">
        <property type="entry name" value="Phosducin-like_chap/apop_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45809">
        <property type="entry name" value="VIRAL IAP-ASSOCIATED FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45809:SF3">
        <property type="entry name" value="VIRAL IAP-ASSOCIATED FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5477906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="242" mass="27423" checksum="01ECDA69EB02BB43" modified="2021-09-29" version="1">MERTADQRIRTTEWEDIQYRFGNRVGKYTTHEREILAQSIADKNQNACLTVYNPHAEKVKAKLERGGYECHEKCEGDDTEIIVESDDEDDALAAIRQRRLVELQRQQAIERFGVLRHIPGADYVAEVTEASSTCWVVAVLMKPGHSDCEALLTVLRTVAQRRRSVKFVSMISTEAIPKFPDGHLPCVLLYRDQELKKQMTGLTVWQAQRQLNVTTVEQVLSHNDVLPRIQDGAGDGTGDSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KMY7</accession>
    <name>A0A836KMY7_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_03250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060815.1">
        <property type="nucleotide sequence ID" value="XM_067205263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KMY7"/>
    <dbReference type="GeneID" id="92359197"/>
    <dbReference type="KEGG" id="loi:92359197"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5471698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="123" mass="13973" checksum="A8C95E5B8E40F05E" modified="2021-09-29" version="1">MSADPEAPADPSRVSGGHIVRNMIYAHDENHNLEILSGWSEQGTREYDQETVRPANASMSKGHPCFSLNQELLRCSLACPAEMKLGGRTATCNTERQALMRCLVKNKQWKPRETEGKPWYRLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KN16</accession>
    <name>A0A836KN16_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">p-nitrophenylphosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_03342</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">LSCM4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="3">Divalent metal ions. Mg(2+) is the most effective.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060905.1">
        <property type="nucleotide sequence ID" value="XM_067205353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KN16"/>
    <dbReference type="SMR" id="A0A836KN16"/>
    <dbReference type="GeneID" id="92359287"/>
    <dbReference type="KEGG" id="loi:92359287"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288">
        <property type="entry name" value="4-NITROPHENYLPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288:SF46">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000915">
        <property type="entry name" value="PGP-type_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5471788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="364" mass="39428" checksum="4E8FFFF84B1D76FD" modified="2021-09-29" version="1">MTQRITQALAARLVASPVKYILLDVDGVIWSGEHVIDRVRETLQYLRDQGKQIRFITNNASLSREELLQSFKKKGIEGVTLKECYNSAYAAALRLKQLLGKADVPGEEPLVHGNVFVIGEQGLHDELQQVLAPGFITYGVELHDAERAGGYDTRVLGDAWRVPCLPPPKKRLVVCTGKMCRVVQAGTDTEEKISLCDLNAAAVVIGLDKHFNMLKLAYGSLVLQGPPEALREEAYSPPLFLATNEDPQLPVGHDAAMIPGAGSLVCALCTAAGRRPDAVCGKPNEDMARILFEAEGITDPREECIMIGDRLTTDVAFGNAAGCQSMLVLSGVEGMADVEEAERQGRTVLLPNYVAESLACFLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KNR5</accession>
    <name>A0A836KNR5_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_04508</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062701.1">
        <property type="nucleotide sequence ID" value="XM_067206492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KNR5"/>
    <dbReference type="GeneID" id="92360426"/>
    <dbReference type="KEGG" id="loi:92360426"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5477290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="80" mass="8882" checksum="79576E3C3B565F71" modified="2021-09-29" version="1">MRHPSWGAYLLWGTFSVRRRTQPRCMSKVLRSLLENPNDTALVGKGAIFVAVDGVKVFAHRWDGAAMAHADVTHGAELFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KPK5</accession>
    <name>A0A836KPK5_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_03536</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061471.1">
        <property type="nucleotide sequence ID" value="XM_067205534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KPK5"/>
    <dbReference type="GeneID" id="92359468"/>
    <dbReference type="KEGG" id="loi:92359468"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5473468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="491" mass="53768" checksum="72AD19E996F3D496" modified="2021-09-29" version="1">MFCAVKHLRAPLATLKPVLADSIATQNAIRRMVGVATARRVNASAINSIAEKTKGEGLAGTTAVVARALLYLLSRNPTEAIAEIDCVLPKVQDEALKRFAVGIRLRSHNELLDMKEAALSVSGGATETEVSDLRSKLQSDYKELVASSPGCWLVELGAAEYRLYTGASEDAYRRFGSIEKKIEEYIKAPINVSELVATTENTNLFSLIGFQVRRARPGARPEGVSAVVAEGMANVMADPAAAKALEQAKKAFGVPVTDEEALELAITLQEADVRHHFHDFFPTTQDHYDRWMSEAAQAAHQLIQEALTPHNAGLKQEAIERIRTSVPNKAFYDSEEKLRALLKSAPKDKSIIASIREAFGPGPSTPISSSDQAVADAVESVHLAVVSSDTAAATDYAKRGKEIAKALAKQLLYRTKVQKSVALIEMNRLQEAVETITPVIHANEYIYMWRAFLARSRAYKGLGLITKADKDLKELNRLKQSLTERTPYEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KQI9</accession>
    <name>A0A836KQI9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein kinase PLK</fullName>
            <ecNumber evidence="8">2.7.11.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Polo-like kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_06913</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.21" evidence="8"/>
    <dbReference type="EMBL" id="JAFHLR010000017">
        <property type="protein sequence ID" value="KAG5481837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064197.1">
        <property type="nucleotide sequence ID" value="XM_067208823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KQI9"/>
    <dbReference type="SMR" id="A0A836KQI9"/>
    <dbReference type="GeneID" id="92362757"/>
    <dbReference type="KEGG" id="loi:92362757"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13118">
        <property type="entry name" value="POLO_box_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13117">
        <property type="entry name" value="POLO_box_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14099">
        <property type="entry name" value="STKc_PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001097">
        <property type="entry name" value="Serine/threonine-protein kinase PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.30:FF:000008">
        <property type="entry name" value="Serine/threonine-protein kinase PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.30:FF:000015">
        <property type="entry name" value="Serine/threonine-protein kinase PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000877">
        <property type="entry name" value="Serine/threonine-protein kinase PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.30">
        <property type="entry name" value="POLO box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033701">
        <property type="entry name" value="POLO_box_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033695">
        <property type="entry name" value="POLO_box_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000959">
        <property type="entry name" value="POLO_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036947">
        <property type="entry name" value="POLO_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF0">
        <property type="entry name" value="CELL CYCLE SERINE_THREONINE-PROTEIN KINASE CDC5_MSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00659">
        <property type="entry name" value="POLO_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82615">
        <property type="entry name" value="Polo-box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50078">
        <property type="entry name" value="POLO_BOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="49"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="POLO box" evidence="11">
        <location>
            <begin position="486"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="POLO box" evidence="11">
        <location>
            <begin position="615"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="375"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5481837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="698" mass="77687" checksum="49D4D1DCE86C8C54" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KR94</accession>
    <name>A0A836KR94_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_05818</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063521.1">
        <property type="nucleotide sequence ID" value="XM_067207748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KR94"/>
    <dbReference type="GeneID" id="92361682"/>
    <dbReference type="KEGG" id="loi:92361682"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5479810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="108" mass="11296" checksum="CF8C6E43BA24D0AA" modified="2021-09-29" version="1">MGGLTQWCVSAVTAVWGKTKCTANLVYNVGGQLRIVYNTSNSHDERKRDLDATVLRAGGFVAATVLCIVVDAKGGMLNALRWLRALVTTENHPSSGCAGAATSTAATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KRS3</accession>
    <name>A0A836KRS3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Midasin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_06101</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">LSCM4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the midasin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000020">
        <property type="protein sequence ID" value="KAG5480335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063666.1">
        <property type="nucleotide sequence ID" value="XM_067208026.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92361960"/>
    <dbReference type="KEGG" id="loi:92361960"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000142">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001053">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002451">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002705">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040848">
        <property type="entry name" value="AAA_lid_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012099">
        <property type="entry name" value="Midasin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041190">
        <property type="entry name" value="Midasin_AAA_lid_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103:SF2">
        <property type="entry name" value="MIDASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103">
        <property type="entry name" value="MIDASIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17865">
        <property type="entry name" value="AAA_lid_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17867">
        <property type="entry name" value="AAA_lid_7"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010340">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="11">
        <location>
            <begin position="4563"/>
            <end position="4708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="3399"/>
            <end position="3426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="3755"/>
            <end position="3774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="3799"/>
            <end position="3840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="3953"/>
            <end position="3984"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="3999"/>
            <end position="4481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="3411"/>
            <end position="3421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="3822"/>
            <end position="3832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="3953"/>
            <end position="3966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="4007"/>
            <end position="4017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="4018"/>
            <end position="4037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="4038"/>
            <end position="4059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="4060"/>
            <end position="4071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="4108"/>
            <end position="4136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="4171"/>
            <end position="4181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="4215"/>
            <end position="4230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="4236"/>
            <end position="4265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="4287"/>
            <end position="4302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="4313"/>
            <end position="4324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="4332"/>
            <end position="4356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="4357"/>
            <end position="4370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="4389"/>
            <end position="4413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="4427"/>
            <end position="4443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="4456"/>
            <end position="4468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR010340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5480335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="4823" mass="533796" checksum="B52AB082E0BC128C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KSC6</accession>
    <name>A0A836KSC6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cysteine protease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_06521</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000019">
        <property type="protein sequence ID" value="KAG5480950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063951.1">
        <property type="nucleotide sequence ID" value="XM_067208439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KSC6"/>
    <dbReference type="SMR" id="A0A836KSC6"/>
    <dbReference type="GeneID" id="92362373"/>
    <dbReference type="KEGG" id="loi:92362373"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000138">
        <property type="entry name" value="Cruzipain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021981">
        <property type="entry name" value="DUF3586"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12131">
        <property type="entry name" value="DUF3586"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032583263" description="Cysteine protease" evidence="9">
        <location>
            <begin position="28"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="11">
        <location>
            <begin position="42"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="10">
        <location>
            <begin position="129"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5480950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="478" mass="52578" checksum="DA5276C5D09EA610" modified="2021-09-29" version="1">MARRNPLLLMVVVAVLFVMFCYPAAIAHELIDVDDDVASARYGQFKKLHGKAFGEDAEEGRRFNAFKENMQRAAFLNAHNPHAHYDVSGKFADLTQEEFAKQYLNPNYYARNLKAHKERAQVYEGVRKNPPAVDWRNHGAVTPVKDQGMCGSCWAFSAIGNIEGQWALNGHALTSLSEQMLVSCDSVDQGCNGGLMDQAWSWIIANHSGTVYTEDSYPYTSRNGEKAPCQHTGKFGAHIDGFVSLAKDEDVIESWLATKGPVSIAVDASTWQLYFGGVVSFCFSFQLNHGVLLVGYNNVAKPPYWIVKNSWGPKWGENGYIRLAKGSNQCMMKNYAMSALVSGTTSSHAPSTTTPPKPNNMVVVHTSCLTSNCSLACRNTTYPTDLCLPRKNGGYVMLTCTHNETVEKVFSSPTCMGKGYEARIPTHHCMESYFGFFQTACVTKVNPEGTNDAVPGFFSPIAVAQPSPSGALKVDDQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KSV7</accession>
    <name>A0A836KSV7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sin-like protein conserved region family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_07969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000013">
        <property type="protein sequence ID" value="KAG5484402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064895.1">
        <property type="nucleotide sequence ID" value="XM_067209845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KSV7"/>
    <dbReference type="GeneID" id="92363779"/>
    <dbReference type="KEGG" id="loi:92363779"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006886">
        <property type="entry name" value="RNA_pol_III_Rpc5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12069:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12069">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES III 80 KDA POLYPEPTIDE RNA POLYMERASE III SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04801">
        <property type="entry name" value="RPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="506"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5484402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="697" mass="76636" checksum="B129DE1D9DE2F45A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KTN2</accession>
    <name>A0A836KTN2_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_05616</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000016">
        <property type="protein sequence ID" value="KAG5482360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064366.1">
        <property type="nucleotide sequence ID" value="XM_067207552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KTN2"/>
    <dbReference type="GeneID" id="92361486"/>
    <dbReference type="KEGG" id="loi:92361486"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045033">
        <property type="entry name" value="PILS1/3/4/5/7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31651">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31651:SF33">
        <property type="entry name" value="PROTEIN PIN-LIKES 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="652"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="694"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="729"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="292"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="339"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5482360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="753" mass="81782" checksum="B2F6E5ABF0380E86" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KU78</accession>
    <name>A0A836KU78_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mannose-1-phosphate guanylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_04620</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.13" evidence="3"/>
    <dbReference type="EMBL" id="JAFHLR010000023">
        <property type="protein sequence ID" value="KAG5478388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063049.1">
        <property type="nucleotide sequence ID" value="XM_067206602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KU78"/>
    <dbReference type="SMR" id="A0A836KU78"/>
    <dbReference type="GeneID" id="92360536"/>
    <dbReference type="KEGG" id="loi:92360536"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004475">
        <property type="term" value="F:mannose-1-phosphate guanylyltransferase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06425">
        <property type="entry name" value="M1P_guanylylT_B_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000013">
        <property type="entry name" value="mannose-1-phosphate guanyltransferase beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045233">
        <property type="entry name" value="GMPPB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050486">
        <property type="entry name" value="Mannose-1P_guanyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22572">
        <property type="entry name" value="SUGAR-1-PHOSPHATE GUANYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="7">
        <location>
            <begin position="11"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="8">
        <location>
            <begin position="270"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5478388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="379" mass="41840" checksum="C70FE191DF76832A" modified="2021-09-29" version="1">MSASNGQEMRALILVGGFGTRLRPLTLTTPKPLVPFCNKPMIIHQIEALKAVGVTEVILAVAYRPEAMKAEMDEWSRKLGVSFVFSVEDEPLGTAGPLALARDILLQDDKPFFVLNSDVTCTFPMQELLNFHKAHGGEGTIMVSQVSQWEKYGVVVYSQQNQQIERFVEKPKTFVGDRINAGIYVFNKSVLNRIPPRRVSIEKEIFPAMAQEGQLYAFNLEGFWMDVGQPKDYIVGMTKFIPSLIGRDRETEELYSETQKHQRGDHFTLIGASLIDPSAKIGEGAVIGPNASIGANCVIGEACRIENAAILENSKLGKGTMVSRSIVGWNNRIGNWCHIEEVSVLGDDVEVKDGVVLVGTKVLPNKDVGEHHFEPGIIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KUV6</accession>
    <name>A0A836KUV6_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_08253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000003">
        <property type="protein sequence ID" value="KAG5488029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066156.1">
        <property type="nucleotide sequence ID" value="XM_067210123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KUV6"/>
    <dbReference type="GeneID" id="92364057"/>
    <dbReference type="KEGG" id="loi:92364057"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5488029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="105" mass="11740" checksum="5CD4190FBA5A594B" modified="2021-09-29" version="1">MERIVRRAARTALSHHSLQITRERAALPRTSLSYAGTWDGPHQMDPRHPLQRIPAGHRSLSMPSGTRARGLVLDSKRAGSALRRSVHRTSSLNPPRVKESHCHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KV47</accession>
    <name>A0A836KV47_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LSCM4_08160</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAFHLR010000002">
        <property type="protein sequence ID" value="KAG5488181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066229.1">
        <property type="nucleotide sequence ID" value="XM_067210031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KV47"/>
    <dbReference type="SMR" id="A0A836KV47"/>
    <dbReference type="GeneID" id="92363965"/>
    <dbReference type="KEGG" id="loi:92363965"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14132">
        <property type="entry name" value="STKc_CK2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000459">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000088">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045216">
        <property type="entry name" value="CK2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054:SF55">
        <property type="entry name" value="CASEIN KINASE II, ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="66"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG5488181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="378" mass="44123" checksum="67C4B86105E7E7BB" modified="2021-09-29" version="1">MSNADAAAHRSDGGKNGSGSGDESKMKKTKPEEYEHPFWYVYRQRGVEYWDYKNARVDFNANLAPYELLQKIGRGKYSEVFRGRNRNNGCLCVLKLLKPVRYQKILREISILRNLCGGPNVVRLLDVLRDSDSQTVVLVTEYVHNPTTLRNLLYSNKLSNFDMRYYLYEILRSLDFAHRRGIFHRDIKPYNVMIDHERKILRVIDWGLGEYYIHGQALNCGVATRHYKGPELLVGYRHYDYSLDIWCLGCVLAGMLFRSDPFFVGANNEDQLLQIVAVFGKKALYRYLDKYQCRISRVVESNLQSLPDEHVDWRRYIKRGSAQESWCDATALDLLDKMLQFDHQDRIMAHDAMQHPFFGPVRDALEKDAQEHYPVAQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KZR1</accession>
    <name>A0A836KZR1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_04973</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAFHLR010000014">
        <property type="protein sequence ID" value="KAG5483818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064757.1">
        <property type="nucleotide sequence ID" value="XM_067206948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KZR1"/>
    <dbReference type="SMR" id="A0A836KZR1"/>
    <dbReference type="GeneID" id="92360882"/>
    <dbReference type="KEGG" id="loi:92360882"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08215">
        <property type="entry name" value="STKc_Nek"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001301">
        <property type="entry name" value="NIMA-related kinase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000631">
        <property type="entry name" value="Serine/threonine-protein kinase NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051131">
        <property type="entry name" value="NEK_Ser/Thr_kinase_NIMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899">
        <property type="entry name" value="CAMK FAMILY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="4"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="302"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="408"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="505"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="302"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="317"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="409"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="428"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5483818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="571" mass="63384" checksum="BE60400AE0E22A92" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836L1B2</accession>
    <name>A0A836L1B2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_05936</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000011">
        <property type="protein sequence ID" value="KAG5485303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065040.1">
        <property type="nucleotide sequence ID" value="XM_067207866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836L1B2"/>
    <dbReference type="SMR" id="A0A836L1B2"/>
    <dbReference type="GeneID" id="92361800"/>
    <dbReference type="KEGG" id="loi:92361800"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001871">
        <property type="entry name" value="ATP-binding cassette, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015854">
        <property type="entry name" value="ABC_transpr_LolD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24220:SF688">
        <property type="entry name" value="ABC TRANSPORTER H FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24220">
        <property type="entry name" value="IMPORT ATP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5485303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="299" mass="32988" checksum="F9942CDA49981125" modified="2021-09-29" version="1">MESVISCDNIHKTYLLGVEGVPALRGVDVDVNPGELLVVYGTSGGGKSTLLNVLGTIDTPTKGNMFLFGKRVTDQTSDSELAALRCQRIGFVFQSFNLISTMNALENVSLPMMIKGSLSSSQIKKRATALLKDVGLGHRLHHFPSMLSGGEQQRVTIARALANEPEILFLDEPTGDLDTKNTLIIMNILLRLNRECGLTMVMVTHDVYMKQYAHRVIYMRDGKVGTTEVVHGDVRQRAWDELQESLRKANIGAEEQKAAISVQRTPEDYATFSAQGPLNLDEDPEMQQVVDVLFGHQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FLA3</accession>
    <name>A0A836FLA3_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_00153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058343.1">
        <property type="nucleotide sequence ID" value="XM_067202242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836FLA3"/>
    <dbReference type="SMR" id="A0A836FLA3"/>
    <dbReference type="GeneID" id="92356176"/>
    <dbReference type="KEGG" id="loi:92356176"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053325">
        <property type="entry name" value="H3-Acetyl_Activator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35706:SF1">
        <property type="entry name" value="EMBRYOGENESIS-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35706">
        <property type="entry name" value="F14O23.11 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5464712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="174" mass="18926" checksum="BEE763429C709E08" modified="2021-09-29" version="1">MLPGSALRRYGAQKQSRSFISAHACSMLMVALDATGLRYPSVSARGAACATAIAGHSSVLCASKRCEHTTTIVPPPEKNPTANKQVDELMDSFTEACELITDARESVGSTYFADDMEDAETQTQDVLKRWDNLQADLEQQGAVEQLQNLRNTYELKIKQLKAELETVREAGGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FLV1</accession>
    <name>A0A836FLV1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Leucine-rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_00524</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058703.1">
        <property type="nucleotide sequence ID" value="XM_067202602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836FLV1"/>
    <dbReference type="SMR" id="A0A836FLV1"/>
    <dbReference type="GeneID" id="92356536"/>
    <dbReference type="KEGG" id="loi:92356536"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050576">
        <property type="entry name" value="Cilia_flagella_integrity"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973:SF29">
        <property type="entry name" value="LEUCINE-RICH REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5465072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="34661" checksum="F250EC0B752B7420" modified="2021-09-29" version="1">METVDGADDCTGATIMTESLVLQQCKSQQGYSTPELNEKIYLHHLGFAKVGGLAAFTGCVVLYLDHNALSDLAGLEALTRLDSLYLSCNALSHLESLPHLPALRTLDVSHNQIVTLRGLDKAAPLLRTLLAGHNRLQRLDGVQGLSRLLSLDVSHNCLEHEKKTSACLHGHRATLRTLLLHGNELCRHTPHHRKRWIAAFPALRFLDDYPVFDDERARAEAFTRGGAAAEADIRSAQHARAVAEARGQFAYYGDFRDAQRDARRRNGAETRPTPYFLTHCTPVNATVAPDDDDEPIYIPAARDVTVHQDPLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FRK0</accession>
    <name>A0A836FRK0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_00948</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059664.1">
        <property type="nucleotide sequence ID" value="XM_067203014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836FRK0"/>
    <dbReference type="SMR" id="A0A836FRK0"/>
    <dbReference type="GeneID" id="92356948"/>
    <dbReference type="KEGG" id="loi:92356948"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF37">
        <property type="entry name" value="2',5'-PHOSPHODIESTERASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="431"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="710"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="710"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="720"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5467862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="843" mass="91585" checksum="D4530F07A875425F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FTM4</accession>
    <name>A0A836FTM4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060024.1">
        <property type="nucleotide sequence ID" value="XM_067204472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836FTM4"/>
    <dbReference type="SMR" id="A0A836FTM4"/>
    <dbReference type="GeneID" id="92358406"/>
    <dbReference type="KEGG" id="loi:92358406"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="63"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5469047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="167" mass="19565" checksum="64AA47F039BD068C" modified="2021-09-29" version="1">MSMTQHIVRRIFGDRKLPENLSNEEYDKYMQENFPKWMKEFEDGGFLEKTKLPPIKSEEELIAKLQEHKDELMVIKYWKHGCIPCLTFAEMYKEAAERCARAQNKIVWYSVDTKALSTRQLIDYQLISGTPTIQTFTGQKQVGNEIRAVNLEELLSELDKRLPKSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FZH0</accession>
    <name>A0A836FZH0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Major vault protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">LSCM4_00187</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The vault ribonucleoprotein particle is a huge (400 A x 670 A) cage structure of 12.9 MDa. It consists of a dimer of half-vaults, with each half-vault comprising 39 identical major vault protein (MVP) chains, PARP4 and one or more vault RNAs (vRNAs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058377.1">
        <property type="nucleotide sequence ID" value="XM_067202276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836FZH0"/>
    <dbReference type="GeneID" id="92356210"/>
    <dbReference type="KEGG" id="loi:92356210"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08825">
        <property type="entry name" value="MVP_shoulder"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.560:FF:000004">
        <property type="entry name" value="Major vault protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.570:FF:000001">
        <property type="entry name" value="major vault protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000010">
        <property type="entry name" value="major vault protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.550:FF:000003">
        <property type="entry name" value="Major vault protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.620:FF:000003">
        <property type="entry name" value="Major vault protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.560">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.570">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.550">
        <property type="entry name" value="Major Vault Protein repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039059">
        <property type="entry name" value="MVP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041139">
        <property type="entry name" value="MVP_rep_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043023">
        <property type="entry name" value="MVP_rep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021870">
        <property type="entry name" value="MVP_shoulder"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041134">
        <property type="entry name" value="Vault_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043179">
        <property type="entry name" value="Vault_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040989">
        <property type="entry name" value="Vault_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041136">
        <property type="entry name" value="Vault_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002499">
        <property type="entry name" value="Vault_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14165">
        <property type="entry name" value="MAJOR VAULT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14165:SF12">
        <property type="entry name" value="VAULT PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11978">
        <property type="entry name" value="MVP_shoulder"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01505">
        <property type="entry name" value="Vault"/>
        <property type="match status" value="2"/>
    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
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                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Thomaz Soccol V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </location>
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        <source>
            <dbReference type="Pfam" id="PF05347"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="11">Isocitrate dehydrogenase [NADP]</fullName>
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    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="11"/>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060161.1">
        <property type="nucleotide sequence ID" value="XM_067204609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G9N3"/>
    <dbReference type="SMR" id="A0A836G9N3"/>
    <dbReference type="GeneID" id="92358543"/>
    <dbReference type="KEGG" id="loi:92358543"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004439">
        <property type="entry name" value="Isocitrate_DH_NADP_dimer_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005425">
        <property type="entry name" value="PRK07006.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00183">
        <property type="entry name" value="prok_nadp_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43504">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NADP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43504:SF1">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NADP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="12">
        <location>
            <begin position="19"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG5469184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="425" mass="46278" checksum="1BA14D6BD67363BC" modified="2021-09-29" version="1">MAEAISFEKGALVVPSHPIIPFIEGDGIGKEITEVAHRVFDAAVTKEYGASRQISWLEVLAGEKAFDQKGTWLPEETIEAFNKYRIGMKGPLTTPVGEGIRSLNVVLRRQLDLFVCQRPVRWFTGVGSPIRHPEWVDMVVFRENTEDIYSGIEWAQGTPEAAKFAAFLQKEMGVTAVRFPETSAYGVKPVSVEGSERLVRAAVQYAVEHHLPSVTLVHKGNIMKYTEGGFKKWGYDVAEREFPEAVFTMTQYDTIKAKSGKDAAETALREATESGKVVIKDCICDAFLQNTILRPLDYSVIATLNLNGDYVSDQLAALVGGIGIAPGANINYATGHAIFEATHGTAPDIAGQGKANPSSLILSGAMMFDYLGWSEVSARIINSLEMVFQANMATGDLARQMTGAKSLSTTEFGEEIIKKINGDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G9N9</accession>
    <name>A0A836G9N9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Wings apart-like protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5468069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059871.1">
        <property type="nucleotide sequence ID" value="XM_067203221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G9N9"/>
    <dbReference type="GeneID" id="92357155"/>
    <dbReference type="KEGG" id="loi:92357155"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="561"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5468069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="593" mass="62776" checksum="8455614DF3D161BA" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GD97</accession>
    <name>A0A836GD97_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_02171</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061242.1">
        <property type="nucleotide sequence ID" value="XM_067204205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GD97"/>
    <dbReference type="GeneID" id="92358139"/>
    <dbReference type="KEGG" id="loi:92358139"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000014">
        <property type="entry name" value="Chaperone protein DnaK HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000020">
        <property type="entry name" value="Chaperone protein HscA homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000026">
        <property type="entry name" value="Heat shock 70-related protein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
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    </dbReference>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="420"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="420"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5472846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="455" mass="49488" checksum="02CA06A351E06F73" modified="2021-09-29" version="1">MDKTKDSLIAVYDLGGGTFDISVLEIAGGVFEVKATNGDTHLGGEDFDLALSDYILEEFRKTSGIDLSKERMALQRVREAAEKAKCELSSAMETEVNLPFITANADGAQHIQMHISRSKFETITEKLIGRSIAPCKQCMKDAGVELKEINDVVLVGGMTRMPKVVEEVKRFFQKEPFRGVNPDEAVALGAATLGGVLRGDVKGLVLLDVTPLSLGIETLGGVFTRMIPKNTTIPTKKSQTFSTAADNQTQVGIKVFQGEREMAADNQLMGQFDLVGIPPAPRGVPQVEVTFDIDANGICHVTAKDKATGKTQNITITANGGLSKEQIEQMIRDSEQHAEADRVKRELVEARNNAETQLTTAEKQLGEWKYVSDAEKENVKALVVELRKAMENPNVAKDDLTAATDKLQKAVMECGRTEYQQAAAANSGSSSSSGGDQQQQQGEQQQQQKTHEEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GDG6</accession>
    <name>A0A836GDG6_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_00696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058873.1">
        <property type="nucleotide sequence ID" value="XM_067202772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GDG6"/>
    <dbReference type="GeneID" id="92356706"/>
    <dbReference type="KEGG" id="loi:92356706"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033579">
        <property type="entry name" value="TMEM128"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20479">
        <property type="entry name" value="TMEM128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5465242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="143" mass="16473" checksum="79284E01A3C72701" modified="2021-09-29" version="1">MHLNAAKMQPETGYTFVKRCSIAVFSFVVICATGMIQECITAERTHNLFLYPSLMLIVAFFSMWGYTARYKIPQDPLWYRHHETYMLIASVLICFGSCMLIVAIYPIYRIWSCAIVILWMVLIGNVNGAVNYIVNRLNKKKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GDM9</accession>
    <name>A0A836GDM9_9TRYP</name>
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        <name evidence="1" type="ORF">LSCM4_03101</name>
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    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060671.1">
        <property type="nucleotide sequence ID" value="XM_067205119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GDM9"/>
    <dbReference type="GeneID" id="92359053"/>
    <dbReference type="KEGG" id="loi:92359053"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5471554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="83" mass="9335" checksum="7CD928FA37D708A4" modified="2021-09-29" version="1">MLRVTVARLQLQRQLYAGGIAYSAAFAARNEHDVDAYQRATALYSPAFTSLRRRKWHVPRQNAYSAKRVLIGTIARSDLGIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GDW3</accession>
    <name>A0A836GDW3_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060615.1">
        <property type="nucleotide sequence ID" value="XM_067205063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GDW3"/>
    <dbReference type="GeneID" id="92358997"/>
    <dbReference type="KEGG" id="loi:92358997"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5470349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="74" mass="7808" checksum="13775E6DC02F691B" modified="2021-09-29" version="1">MSALNITCSGAVYHGCSTLEVMRYRCPQWQPGNDMPVNASPEDADEPVEDAGEDAAAETSGSAETPETSEGDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GF28</accession>
    <name>A0A836GF28_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal lipase-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_01392</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059137.1">
        <property type="nucleotide sequence ID" value="XM_067203446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GF28"/>
    <dbReference type="SMR" id="A0A836GF28"/>
    <dbReference type="GeneID" id="92357380"/>
    <dbReference type="KEGG" id="loi:92357380"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="2">
        <location>
            <begin position="273"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="518"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="391"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5466247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="545" mass="60023" checksum="7FD025917C51136C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GFT9</accession>
    <name>A0A836GFT9_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_02153</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061225.1">
        <property type="nucleotide sequence ID" value="XM_067204188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GFT9"/>
    <dbReference type="GeneID" id="92358122"/>
    <dbReference type="KEGG" id="loi:92358122"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5472829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="351" mass="38943" checksum="4CD78F3FAD376E5E" modified="2021-09-29" version="1">MPAHVTHTAFGAEDCSIDARFLSHMAFLCSPDKPVETSTVIGKYAVSEICVSEAEAADIKMYFETLRSPGQTAYVSKLTAEMHRAAAACGDNAMAEAADAMMAEYKRFKSVFFLRMRAFVVIHVEKNETVGRILTFPDQISDDYGNNLDEHSEQGINQAKVSQAQFAERLPTVYVGHAQGAAMAKLCACAYGRQAILFDGTTLSELLVHNAVEQRCVQPEPMDDEEKLWNLIHYRTEAFAKKQDATAKATMVAVKKIDAEEKAAREAAMAAKEEEEKKTGAYAIQVAKKAEDDYYAAKMWLEKSEWNMIGGIIPTVAQTRFARTGRYNAKALSDMFVDYTVSLRASQDPYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GG97</accession>
    <name>A0A836GG97_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_03143</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060711.1">
        <property type="nucleotide sequence ID" value="XM_067205159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GG97"/>
    <dbReference type="SMR" id="A0A836GG97"/>
    <dbReference type="GeneID" id="92359093"/>
    <dbReference type="KEGG" id="loi:92359093"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="392"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5471594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="454" mass="48148" checksum="8559F647A61E85E8" modified="2021-09-29" version="1">MASGASVSPHLLSESVEKHCAADIYALHHRLDRCLKQVEKLTSSSAGDADVSRYECDRAGTSCIRRLGQLLREARRLAQRVEEAAGDKASDAQATVEPVDDGVDTPLRAYYRQQLQARFAHLQQDADAAQRLLMQYLSNNPTLAHLPVSCVGTAPRILECGLTGATAASFGSTSRIYADSVPPHAAHIPPAAVYSIEGASSAAAGTQNSSVARGSVAETKKEADSKEREASAAASLSGHAMGTSAAAGPAITAEDRIMEDIQQAIQQMKDGALQMSALMEQEKSRMKSATDLLSGGIAKGHANMHDLDRVSYVAEAAHVPWLLRCMPGMPILWRTVLQPMWAFVKQVLMMSFIIAVTGCVLLLISFLPKPTVYRVQRSRTHDSRVSPLQSTAASAPAPVAAPASPPPVVNASPSASYEAETHVSIEPAAPAKTVHETAAASRAQSGPAEFLDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GGH1</accession>
    <name>A0A836GGH1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fanconi-associated nuclease</fullName>
            <ecNumber evidence="5">3.1.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_00277</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.</text>
            <dbReference type="EC" id="3.1.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FAN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.1" evidence="5"/>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058466.1">
        <property type="nucleotide sequence ID" value="XM_067202365.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92356299"/>
    <dbReference type="KEGG" id="loi:92356299"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070336">
        <property type="term" value="F:flap-structured DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004528">
        <property type="term" value="F:phosphodiesterase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033315">
        <property type="entry name" value="Fan1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014883">
        <property type="entry name" value="VRR_NUC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15749">
        <property type="entry name" value="FANCONI-ASSOCIATED NUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15749:SF4">
        <property type="entry name" value="FANCONI-ASSOCIATED NUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08774">
        <property type="entry name" value="VRR_NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VRR-NUC" evidence="7">
        <location>
            <begin position="1633"/>
            <end position="1708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="143"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="576"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="764"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1452"/>
            <end position="1502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="580"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="600"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="786"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1461"/>
            <end position="1483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5464835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1723" mass="185323" checksum="EB94AAFB38349921" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GGR8</accession>
    <name>A0A836GGR8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_00466</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058646.1">
        <property type="nucleotide sequence ID" value="XM_067202545.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92356479"/>
    <dbReference type="KEGG" id="loi:92356479"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045050">
        <property type="entry name" value="Synaptotagmin_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10774:SF190">
        <property type="entry name" value="C2 CALCIUM_LIPID-BINDING ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10774">
        <property type="entry name" value="EXTENDED SYNAPTOTAGMIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="773"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="1101"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="1477"/>
            <end position="1592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="935"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1658"/>
            <end position="1717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2126"/>
            <end position="2151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="935"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="961"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1673"/>
            <end position="1686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1687"/>
            <end position="1717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5465015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="2151" mass="236832" checksum="FCABF028383CBDF7" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GGT1</accession>
    <name>A0A836GGT1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Acetyl-CoA carboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">LSCM4_03407</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">LSCM4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(6)-biotinyl-L-lysyl-[protein] + hydrogencarbonate + ATP = N(6)-carboxybiotinyl-L-lysyl-[protein] + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13501"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>hydrogencarbonate + acetyl-CoA + ATP = malonyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11308"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060966.1">
        <property type="nucleotide sequence ID" value="XM_067205414.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836GGT1"/>
    <dbReference type="GeneID" id="92359348"/>
    <dbReference type="KEGG" id="loi:92359348"/>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000005">
        <property type="entry name" value="Acetyl-CoA carboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000003">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000010">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.460.10">
        <property type="entry name" value="Biotin dependent carboxylase carboxyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1770.10">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049076">
        <property type="entry name" value="ACCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049074">
        <property type="entry name" value="ACCA_BT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013537">
        <property type="entry name" value="AcCoA_COase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728:SF3">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08326">
        <property type="entry name" value="ACC_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21385">
        <property type="entry name" value="ACCA_BT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0092">Biotin</keyword>
    <keyword evidence="9" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="16">
        <location>
            <begin position="30"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="15">
        <location>
            <begin position="180"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="17">
        <location>
            <begin position="1410"/>
            <end position="1752"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="18">
        <location>
            <begin position="1761"/>
            <end position="2056"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAG5471849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="21">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2168" mass="240518" checksum="0E167A9E277BF093" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GIF2</accession>
    <name>A0A836GIF2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Anaphase-promoting complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_02117</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061190.1">
        <property type="nucleotide sequence ID" value="XM_067204153.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836GIF2"/>
    <dbReference type="GeneID" id="92358087"/>
    <dbReference type="KEGG" id="loi:92358087"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000724">
        <property type="entry name" value="Cyclosome subunit-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024990">
        <property type="entry name" value="Apc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827:SF3">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827">
        <property type="entry name" value="MEIOTIC CHECKPOINT REGULATOR TSG24 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="82"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="320"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5472794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2151" mass="232007" checksum="EA3D4208A6237FA4" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GJ67</accession>
    <name>A0A836GJ67_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_00280</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058469.1">
        <property type="nucleotide sequence ID" value="XM_067202368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GJ67"/>
    <dbReference type="SMR" id="A0A836GJ67"/>
    <dbReference type="GeneID" id="92356302"/>
    <dbReference type="KEGG" id="loi:92356302"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106335">
        <property type="term" value="F:tRNA (5-carboxymethyluridine(34)-5-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051422">
        <property type="entry name" value="AlkB_tRNA_MeTrf/Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13069">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB HOMOLOG 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13069:SF21">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB HOMOLOG 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="4">
        <location>
            <begin position="194"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5464838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="340" mass="37721" checksum="6796F4656CB964AC" modified="2021-09-29" version="1">MPVNCAGLAAAPDTKKARVETGEGAEAGPAPVFPSSSTDAAAYEREHVHKVYSAIAEHFSSTRYKAWPRVGSFLESLPPFSLVADVGCGNGKYFAAAQRLALTTPSCSMGAPDDILEKSSRQQVAAPPSSPLVSFAPAHRYIVGLDYSEELLRSTQRQLLDPNVHPESPGRRFRGDHAKIEVDVMPAPVSVEELPRTDTVRSDALRCPLRGGVFDAAISIAVIHHYASRERRRLAVRELLRLVRPGGGRVLIYVWAREQRGRTKRPVDPETGDGLVRWERHEKYDQARQVFHRYYHFFAEGELEQLCRDAGGDDGGGAVPVLIRESYYDKENWCVILERC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GMZ4</accession>
    <name>A0A836GMZ4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_04076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062002.1">
        <property type="nucleotide sequence ID" value="XM_067206065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GMZ4"/>
    <dbReference type="GeneID" id="92359999"/>
    <dbReference type="KEGG" id="loi:92359999"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5475494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="465" mass="52163" checksum="367375D04909F5A3" modified="2021-09-29" version="1">MRRLFRNAFCSAMPRARPARDWTGARHLAISATIVAGAAPVCAMQQRWSSSLHGASDSTGQQTRPPSSTSPDRPDPFLGVVQITAKNITTEMESKVPLFLYFTVANHPDVKQYTELLSHQVDQANRRLKGDNFGELYQEFGRDAGLAIKLGVVDCLHEPGLMAKFQIDPHMFPLIYFVRNKVFCDKLVGIVAESHVKEAVEAFIEYAKAESKNELEGSSLLQKVKRQDNDDENAMTLLAAAHSKMQSGDPAKGKKLFEKALRLSMEDIEVVKKRYGVPNKKMTPELWAKLKREPCYNSAPEALCGLAMCALASKQRGEAFRLAAQVREEFPFAPRDMRSVAEAVVRIELIQLVDYDPDTDNYMRLLKFDELVSEPTQFYKHHLKRAVAFYVEGVVGQAIEECLRLIRAEPKLLVALKKEGIVPKDLRLGPTAVTPARQVIRAIFEALGPTNEHVEKGRKLLQLYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GN68</accession>
    <name>A0A836GN68_9TRYP</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_04211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062137.1">
        <property type="nucleotide sequence ID" value="XM_067206200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GN68"/>
    <dbReference type="GeneID" id="92360134"/>
    <dbReference type="KEGG" id="loi:92360134"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5475629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="379" mass="42659" checksum="7698135F5D859B19" modified="2021-09-29" version="1">MASKSHFEVRLNGCATTAVKISEARDRVADAKRVILEADDHLRQIRKVYRALGLVPVTPSPPTATALTVPLPVLHSSRAVHDEHPANMALPTLRKSFNDVFSLAAQYSAGALEVTSRDSPTLCTVTSMPNIQQHSPKVISEPPVSVVAANALNYVAAWRKEDSRCTLQEDVIHDCLRVRYNLEVEEQGSRHRLRQLLLTVWEQMDRFVVMSEYSKFVVFCVHQEPMWRQAAHQLKKEKDARLNTAESILTHFQMEEVALTEKMFMFQEAAGFVSQCFAKWEKRQLTQTRAAERRRGLQSARQMTCVQFTPHSHPHHRGSHDDGDDAAPAVSSTLPPLQRPRGDSLLALSGKREARAAQKVEPLSAVEMCSYTPPRRTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GQ31</accession>
    <name>A0A836GQ31_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_00969</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059685.1">
        <property type="nucleotide sequence ID" value="XM_067203035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GQ31"/>
    <dbReference type="SMR" id="A0A836GQ31"/>
    <dbReference type="GeneID" id="92356969"/>
    <dbReference type="KEGG" id="loi:92356969"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000673">
        <property type="entry name" value="TPR-repeat-containing chaperone protein DNAJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000786">
        <property type="entry name" value="TPR-repeat-containing chaperone protein DNAJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052758">
        <property type="entry name" value="SRC_co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44200:SF2">
        <property type="entry name" value="CHAPERONE PROTEIN DNAJ, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44200">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
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    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="340"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="4">
        <location>
            <begin position="695"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="665"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="320"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5467883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="803" mass="87691" checksum="CAE6CC45F2DCA676" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GQ45</accession>
    <name>A0A836GQ45_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ENT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5477944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062851.1">
        <property type="nucleotide sequence ID" value="XM_067207283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GQ45"/>
    <dbReference type="SMR" id="A0A836GQ45"/>
    <dbReference type="GeneID" id="92361217"/>
    <dbReference type="KEGG" id="loi:92361217"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1240.40">
        <property type="entry name" value="ENT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036142">
        <property type="entry name" value="ENT_dom-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="200"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5477944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="227" mass="24661" checksum="C1160DB33F366224" modified="2021-09-29" version="1">MESYAAPAGPQPPHVVYDTLSKAHKAAPQLKPIPAFEVYKVAREEELAAYRMLCRVLVMHHGTSLPKAQQRILDDMGEELCIGQERQSLEKEMAEQDKVLQGIRKSGVLRRRGDFTDGVEEMTVEDYLAEAPKDDGNGLYMPAPKALRADGADSGAARATAAAAAAAVGAKRKGHIHAAVSKLAKEIESAGRNLLLSTSAQEEQQLIQLLQQKREALVALRVELTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GTV9</accession>
    <name>A0A836GTV9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydrolase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_08292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000003">
        <property type="protein sequence ID" value="KAG5488067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066194.1">
        <property type="nucleotide sequence ID" value="XM_067210161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GTV9"/>
    <dbReference type="SMR" id="A0A836GTV9"/>
    <dbReference type="GeneID" id="92364095"/>
    <dbReference type="KEGG" id="loi:92364095"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01300">
        <property type="entry name" value="YtcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033932">
        <property type="entry name" value="YtcJ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642">
        <property type="entry name" value="IMIDAZOLONEPROPIONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642:SF2">
        <property type="entry name" value="PROTEIN LONG AFTER FAR-RED 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase 3" evidence="1">
        <location>
            <begin position="86"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5488067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="690" mass="75814" checksum="1D2A8B86BB8513EB" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GTW0</accession>
    <name>A0A836GTW0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin-ribosomal protein eL40 fusion protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_00060</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the ubiquitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058251.1">
        <property type="nucleotide sequence ID" value="XM_067202150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GTW0"/>
    <dbReference type="SMR" id="A0A836GTW0"/>
    <dbReference type="GeneID" id="92356084"/>
    <dbReference type="KEGG" id="loi:92356084"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000285">
        <property type="entry name" value="Putative ubiquitin/ribosomal protein S27a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002906">
        <property type="entry name" value="Ribosomal_eS31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038582">
        <property type="entry name" value="Ribosomal_eS31_euk-type_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01599">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01402">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="53"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5464620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="204" mass="22817" checksum="69C189C20C55B5D5" modified="2021-09-29" version="1">MLPYATSPFSCLLALSFFVCAPRRGVLLLLTTMATSTTVPLPPSLQRRKREAMQIFIKNAAGRTVVVRLSAEDTVASLKAQADVREGNLFFAGMCLAEDETLAAYGVSQESTIDVVVPVEGGKGKKKKKRIFTKPKKPTHRHKLEKMRALKYFKVTENDDGSYRVERTRQDCPHPQCGAGVYMAQHKDRQYCGKCHLTYKAECK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GUG7</accession>
    <name>A0A836GUG7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vesicle-fusing ATPase</fullName>
            <ecNumber evidence="9">3.6.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_06155</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">LSCM4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.6" evidence="9"/>
    <dbReference type="EMBL" id="JAFHLR010000020">
        <property type="protein sequence ID" value="KAG5480389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063720.1">
        <property type="nucleotide sequence ID" value="XM_067208080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GUG7"/>
    <dbReference type="SMR" id="A0A836GUG7"/>
    <dbReference type="GeneID" id="92362014"/>
    <dbReference type="KEGG" id="loi:92362014"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000026">
        <property type="entry name" value="vesicle-fusing ATPase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000166">
        <property type="entry name" value="vesicle-fusing ATPase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000187">
        <property type="entry name" value="Vesicular-fusion ATPase SEC18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039812">
        <property type="entry name" value="Vesicle-fus_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23078:SF3">
        <property type="entry name" value="VESICLE-FUSING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23078">
        <property type="entry name" value="VESICULAR-FUSION PROTEIN NSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
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</entry>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">LSCM4</strain>
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<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
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                <person name="Al-Salem W.S."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG5470328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <location>
            <begin position="16"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="703"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="795"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="802"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="819"/>
            <end position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5470328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="849" mass="87752" checksum="DE6654EA805A5BB9" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GWZ9</accession>
    <name>A0A836GWZ9_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061448.1">
        <property type="nucleotide sequence ID" value="XM_067205511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GWZ9"/>
    <dbReference type="GeneID" id="92359445"/>
    <dbReference type="KEGG" id="loi:92359445"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="623"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="632"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5473445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="725" mass="77099" checksum="92575A79C80F5958" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GXH3</accession>
    <name>A0A836GXH3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Cytoplasmic dynein 2 heavy chain 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="30" type="ORF">LSCM4_04251</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="31" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="31" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Cilium membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dynein heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="30">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062175.1">
        <property type="nucleotide sequence ID" value="XM_067206238.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836GXH3"/>
    <dbReference type="GeneID" id="92360172"/>
    <dbReference type="KEGG" id="loi:92360172"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060170">
        <property type="term" value="C:ciliary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein 1 heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.30:FF:000006">
        <property type="entry name" value="Cytoplasmic dynein 2 heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000706">
        <property type="entry name" value="Cytoplasmic dynein 2 heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000071">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.20:FF:000004">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000598">
        <property type="entry name" value="Dynein cytoplasmic 2 heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001685">
        <property type="entry name" value="Dynein heavy chain, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054354">
        <property type="entry name" value="DYNC2H1-like_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703:SF22">
        <property type="entry name" value="DYNEIN CYTOPLASMIC 2 HEAVY CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703">
        <property type="entry name" value="DYNEIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22597">
        <property type="entry name" value="DYN_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17" id="KW-0966">Cell projection</keyword>
    <keyword evidence="13" id="KW-0969">Cilium</keyword>
    <keyword evidence="9" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="12 19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="11" id="KW-0243">Dynein</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="15" id="KW-0505">Motor protein</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain linker" evidence="22">
        <location>
            <begin position="1234"/>
            <end position="1665"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain hydrolytic ATP-binding dynein motor region" evidence="23">
        <location>
            <begin position="1793"/>
            <end position="2131"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein 2 heavy chain 1 cytoplasmic ATPase lid" evidence="29">
        <location>
            <begin position="2607"/>
            <end position="2680"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA module D4" evidence="25">
        <location>
            <begin position="2780"/>
            <end position="2984"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain coiled coil stalk" evidence="24">
        <location>
            <begin position="3036"/>
            <end position="3370"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain ATP-binding dynein motor region" evidence="26">
        <location>
            <begin position="3394"/>
            <end position="3615"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain region D6 P-loop" evidence="21">
        <location>
            <begin position="3864"/>
            <end position="3974"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA lid" evidence="27">
        <location>
            <begin position="4007"/>
            <end position="4142"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain C-terminal" evidence="28">
        <location>
            <begin position="4175"/>
            <end position="4441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="232"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="671"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1292"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="3045"/>
            <end position="3114"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="3254"/>
            <end position="3330"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="3549"/>
            <end position="3583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="201"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="681"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="1300"/>
            <end position="1320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF03028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF08393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF12774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF12777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF12780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF12781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF18198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF18199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="Pfam" id="PF22597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="KAG5475667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="4445" mass="498503" checksum="45E8747444C727B9" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GXM2</accession>
    <name>A0A836GXM2_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_01215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058968.1">
        <property type="nucleotide sequence ID" value="XM_067203277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GXM2"/>
    <dbReference type="SMR" id="A0A836GXM2"/>
    <dbReference type="GeneID" id="92357211"/>
    <dbReference type="KEGG" id="loi:92357211"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000009">
        <property type="entry name" value="Carnitinyl-CoA dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000001">
        <property type="entry name" value="Probable enoyl-CoA hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF171">
        <property type="entry name" value="SD19268P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5466078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="297" mass="31510" checksum="AD6E5E4F177165B2" modified="2021-09-29" version="1">MRTCNRLRAAVAADPSVTNFKVLHECECVLRYDATSQIAILSMERQARKNAIGTCFLECIRRAIGVCTAGAPSSACTTAATDCPSVRCLIVSSAVPNVFCAGADLKERKEMSVAESRAFVQRLRQTFNDLEDLPIPTIAAIEGKALGGGMELALSLDMRVAGDRATMGFPETGLAIIPGAGGTVRAPAVIGVSRALELILTAEQVSAQRALELGLVNRVVPAGSALDTALDLALRISKNGPLGVRAAKRAVRFAVGKPRSEAMQVEAEQYDVVLATEDRLEGLKAFAEHRTPVYKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GZ70</accession>
    <name>A0A836GZ70_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_00932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059648.1">
        <property type="nucleotide sequence ID" value="XM_067202998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GZ70"/>
    <dbReference type="SMR" id="A0A836GZ70"/>
    <dbReference type="GeneID" id="92356932"/>
    <dbReference type="KEGG" id="loi:92356932"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5467846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="321" mass="35887" checksum="4C974AE53B9118F5" modified="2021-09-29" version="1">MTVVFDADALEVWKRQVREVANAGELRAEQVLSFLDSLERIGHTTEHKQAMPLRKCYRDSDPAQMAPPQHTRVSVGTQLWTVHPIHYAHHVLNEVRRERQVKVLSRRLGVLAADLHTVAHDLWKLLQASSTGQPLTAAPTLYDTANTEALDRAASVAAAPCSENRVWHGVSLSTYQTLRSLFGYLPDFDADQLLDWSNRTIPSLMTPASSSVPSRLKRQVDACVQTPQEFVAEQAAADTPGERLLFLCRHCRQDGRAGYQIAEGRMQLTQIHDIGSANRDRGRPPPLTSPALRCTVTRRADHPLSQNGGAHRPRRRMLPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GZD9</accession>
    <name>A0A836GZD9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein artemis</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">DNA cross-link repair 1C protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LSCM4_01053</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059768.1">
        <property type="nucleotide sequence ID" value="XM_067203118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GZD9"/>
    <dbReference type="GeneID" id="92357052"/>
    <dbReference type="KEGG" id="loi:92357052"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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</entry>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <dbReference type="EMBL" id="KAG5468056.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
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</entry>
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        <submittedName>
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        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
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                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <comment type="caution">
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="4">Uncharacterized protein</fullName>
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                <person name="Al-Salem W.S."/>
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                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_067206879.1"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032908238" evidence="3">
        <location>
            <begin position="48"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="386"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5483749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="404" mass="43602" checksum="CA1F0915D5020E83" modified="2021-09-29" version="1">MAPLTTSSEVAALRRQWSRTPMSVHILKAALLLALLLLGACSSVSLAVDAVEKHPVTAREGMHAQFAWPASAAVTAALDMKGSDVHVLRKQLVREVNHQNWHLLDGDLLIPADAKNVARLHPRRDAPLKGVLECGSSPSQAAEARAEVDPHSPLAGVHRAGHVAVDTRQDSTLAGERHRRTEHHAHVTSSRHQHKTIADEAVVDAAEKYTEAQPSRITLDSLRLLILFKDEAADEEEGAEGHEHGDDKHAATHSRGSGYQRWRARNSNAHRGQSFSVSPGQQGVGERRVATASKPITAKVAAELHDMARRCDGRDAALVSRDAKGASTMQIEEEMCRRCLVASTRDSKGALITALQEGSSREHCLIVVADVGNDIPRSGNNAKGDAAILSLLVSILFGAFLFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H227</accession>
    <name>A0A836H227_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA-specific adenosine deaminase 1</fullName>
            <ecNumber evidence="8">3.5.4.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">tRNA-specific adenosine-37 deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LSCM4_02333</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically deaminates adenosine-37 to inosine in tRNA-Ala.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>adenosine(37) in tRNA(Ala) + H2O + H(+) = inosine(37) in tRNA(Ala) + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:50968"/>
            <dbReference type="Rhea" id="RHEA-COMP:12855"/>
            <dbReference type="Rhea" id="RHEA-COMP:12856"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:82852"/>
            <dbReference type="EC" id="3.5.4.34"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>1D-myo-inositol hexakisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the ADAT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.34" evidence="8"/>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5468940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059917.1">
        <property type="nucleotide sequence ID" value="XM_067204365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H227"/>
    <dbReference type="GeneID" id="92358299"/>
    <dbReference type="KEGG" id="loi:92358299"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043829">
        <property type="term" value="F:tRNA-specific adenosine-37 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002466">
        <property type="entry name" value="A_deamin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46516">
        <property type="entry name" value="TRNA-SPECIFIC ADENOSINE DEAMINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46516:SF1">
        <property type="entry name" value="TRNA-SPECIFIC ADENOSINE DEAMINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02137">
        <property type="entry name" value="A_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50141">
        <property type="entry name" value="A_DEAMIN_EDITASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="A to I editase" evidence="13">
        <location>
            <begin position="120"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG5468940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="602" mass="65080" checksum="477DB87EA0D357B8" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H2S0</accession>
    <name>A0A836H2S0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ABC3 transporter permease C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_04659</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000023">
        <property type="protein sequence ID" value="KAG5478427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063088.1">
        <property type="nucleotide sequence ID" value="XM_067206641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H2S0"/>
    <dbReference type="GeneID" id="92360575"/>
    <dbReference type="KEGG" id="loi:92360575"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32522">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32522:SF5">
        <property type="entry name" value="ABC3 TRANSPORTER PERMEASE PROTEIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="440"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="489"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="548"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="579"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="639"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="974"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1021"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1064"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="domain" description="ABC3 transporter permease C-terminal" evidence="7">
        <location>
            <begin position="400"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="ABC3 transporter permease C-terminal" evidence="7">
        <location>
            <begin position="977"/>
            <end position="1096"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5478427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1103" mass="121764" checksum="FC423E6A0FECF62D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H2V7</accession>
    <name>A0A836H2V7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Scaffold protein Nfu/NifU N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_02366</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NifU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5468973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059950.1">
        <property type="nucleotide sequence ID" value="XM_067204398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H2V7"/>
    <dbReference type="SMR" id="A0A836H2V7"/>
    <dbReference type="GeneID" id="92358332"/>
    <dbReference type="KEGG" id="loi:92358332"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.70:FF:000004">
        <property type="entry name" value="HIRA-interacting protein 5, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.70">
        <property type="entry name" value="Scaffold protein Nfu/NifU, N-terminal domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014824">
        <property type="entry name" value="Nfu/NifU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036498">
        <property type="entry name" value="Nfu/NifU_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001075">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178">
        <property type="entry name" value="IRON-SULFUR CLUSTER SCAFFOLD PROTEIN NFU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178:SF52">
        <property type="entry name" value="PROTEIN 5, PUTATIVE-RELATED"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF08712">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Scaffold protein Nfu/NifU N-terminal" evidence="3">
        <location>
            <begin position="72"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="400"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5468973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="443" mass="47071" checksum="6AE4B4C069596134" modified="2021-09-29" version="1">MRTRMLCVRRYAGLPGRATVSCVEIGGLDVSLTASVSAAPTIWRRGLAFPHSASRSSLASSSWCTPQRAVFVRFQPTPNDACFKFCVDEMQFLPPNMNTMVFDSTNSYLSPLAHTLLEALPMVEEVTVGTSFVTVKRVDEADMAAAARHFAMKFHQAGRDHGTDEAAAEARSQALQQNIADVLKDDGEAAALRRSGSATFTAPSLSPFDVGGFTVSPSSQDEQVDIGALHSLIAATDWSELKFHVSALLTDHICSGNPHVDPSAPNPHADTVPAEGDSEVVLMIKELMATTIRPQLQDDGGDLRFVGFDPVSGDMRVELLGACRTCTSSKTTLMDLIERTTRHWIPEVKSVKDVSRAASVLKELSARHDRAAEGAPDPSLSSLADQVAGKVDDGLPKANGTVQLSPSATSAPAQAVSGAYKILRKVRASSHGEATTASAAAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H364</accession>
    <name>A0A836H364_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060100.1">
        <property type="nucleotide sequence ID" value="XM_067204548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H364"/>
    <dbReference type="GeneID" id="92358482"/>
    <dbReference type="KEGG" id="loi:92358482"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="311"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="338"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="516"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5469123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="530" mass="53415" checksum="C9FD6D2AEF44A1AB" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H3U0</accession>
    <name>A0A836H3U0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Archaic translocase outer mitochondrial membrane 46 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03837</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061769.1">
        <property type="nucleotide sequence ID" value="XM_067205832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H3U0"/>
    <dbReference type="SMR" id="A0A836H3U0"/>
    <dbReference type="GeneID" id="92359766"/>
    <dbReference type="KEGG" id="loi:92359766"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001309">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
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        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5474663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="411" mass="45683" checksum="CF1ACCF0B208B132" modified="2021-09-29" version="1">MESPINPAVWQVLFNAAVGTLSVAALYSVYHQRYDMESAQRAAFLELRKADSEEARVAKLTELQAACKPEVVRRQPSARMSALKYGAPIVQMAKLQKDGSNVASVRVAIKVILYIYGPDAEGRRKLDRLDGYRVLLTTLSEAQRQGEEDLKEDVAQALDALTEVDDSEVVLDTDVPRGSEGTATLARLPATVKMLRILDPEGSVVFLASLTGIFANICTLAEGATNIGGGVDGHSGMSFFLRLLDHSNRRVVANAVTVVRFLARAQVCQEELIEEENLVRLAENLHPTGEPVVVNSILTVILVMAGSKKYGEAFFSGIASSTIPTTLFELWTRSPEKSLRSRAEVLSRLLLRIPQTAPVVAALFERFRPQLEERRRRDEEEYKQHMQQMQQNQMMQRMMMEQMGIDPSMMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H461</accession>
    <name>A0A836H461_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_04005</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061934.1">
        <property type="nucleotide sequence ID" value="XM_067205997.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836H461"/>
    <dbReference type="GeneID" id="92359931"/>
    <dbReference type="KEGG" id="loi:92359931"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1470.10">
        <property type="entry name" value="Photosystem I PsaD, reaction center subunit II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053233">
        <property type="entry name" value="ABRA-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21715">
        <property type="entry name" value="RH04127P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21715:SF3">
        <property type="entry name" value="WW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="3">
        <location>
            <begin position="75"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="122"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="322"/>
            <end position="347"/>
        </location>
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        <location>
            <begin position="633"/>
            <end position="663"/>
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        <location>
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        <location>
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        <location>
            <begin position="420"/>
            <end position="480"/>
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        <location>
            <begin position="729"/>
            <end position="783"/>
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        <location>
            <begin position="1110"/>
            <end position="1147"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="640"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="930"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1238"/>
            <end position="1250"/>
        </location>
    </feature>
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        <location>
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            <end position="1305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1309"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1324"/>
            <end position="1337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5474828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1345" mass="146027" checksum="7AD9278AB5575195" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H5G7</accession>
    <name>A0A836H5G7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">60S ribosomal protein L2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_03079</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060649.1">
        <property type="nucleotide sequence ID" value="XM_067205097.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="92359031"/>
    <dbReference type="KEGG" id="loi:92359031"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ribosomal_uL2_arc_euk"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ribosomal_uL2_RNA-bd_dom"/>
    </dbReference>
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        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
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    </dbReference>
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        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="RIBOSOMAL PROTEIN L2"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ribosomal_L2"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
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            <end position="231"/>
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5470383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="28273" checksum="7896A12A83DA59E3" modified="2021-09-29" version="1">MGKTVLSCRKGNGSVYQVHGHKRLGPAKLRILDYAERHGYMRGVVKSIEHEAGRGAALARVEFRHPYKFRRVKELMVAPEGMFTGQSVFCGQKAPLAIGNVLPLGQITEGCIVCNVEAKPGDRGTLARASGDYCIIISHNHETGRTRLKLPSGQKKSVPSTSRAMIGIISGGGRIEKPVLKAGNSFYRFRGKRNCWPKVRGVARNPVEHPHGGGNHQHIGHPSTVSRHSPPGQKVGLIAARRTGRIRGGKAVKGAWHPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H6P9</accession>
    <name>A0A836H6P9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">6-phosphofructo-2-kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_05014</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062291.1">
        <property type="nucleotide sequence ID" value="XM_067206988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H6P9"/>
    <dbReference type="SMR" id="A0A836H6P9"/>
    <dbReference type="GeneID" id="92360922"/>
    <dbReference type="KEGG" id="loi:92360922"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003147">
        <property type="entry name" value="6-phosphofructo-2-kinase/fructose-2,6-biphosphata se-1-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF40">
        <property type="entry name" value="6-BIPHOSPHATASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="122"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="5">
        <location>
            <begin position="218"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="503"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="509"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5476058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="669" mass="74544" checksum="825CE0362077131D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H6S4</accession>
    <name>A0A836H6S4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CHCH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_07525</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000004">
        <property type="protein sequence ID" value="KAG5487846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066043.1">
        <property type="nucleotide sequence ID" value="XM_067209411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H6S4"/>
    <dbReference type="GeneID" id="92363345"/>
    <dbReference type="KEGG" id="loi:92363345"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010625">
        <property type="entry name" value="CHCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055304">
        <property type="entry name" value="CHCHD2/10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13523:SF2">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13523">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 2/NUR77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06747">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHCH" evidence="3">
        <location>
            <begin position="116"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5487846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="153" mass="16029" checksum="C3D9B5CB503B78B4" modified="2021-09-29" version="1">MARSRAAPRASSGSSRSPAAPPPQPKKAEPLHQSTQHTHSQAHPQQPTGVTNIFVQRPMAGGGGSGILGTMAAVAGGSVLGHGISSYLYGHNNQAPTQPAEAQQLAQAAQQEGHACTPQLVGYSKCLEANPESADSCKWAWDYFTQCQKENPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H7Z6</accession>
    <name>A0A836H7Z6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_07422</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000008">
        <property type="protein sequence ID" value="KAG5486489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065555.1">
        <property type="nucleotide sequence ID" value="XM_067209312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H7Z6"/>
    <dbReference type="SMR" id="A0A836H7Z6"/>
    <dbReference type="GeneID" id="92363246"/>
    <dbReference type="KEGG" id="loi:92363246"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039903">
        <property type="entry name" value="Zswim2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21540:SF3">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZSWIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21540">
        <property type="entry name" value="RING FINGER AND SWIM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="6">
        <location>
            <begin position="48"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="109"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="274"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5486489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="41416" checksum="666844D15A6EDD6D" modified="2021-09-29" version="1">MTRTQMWVEECPDRIRKRIDAAIKSHMSIEQLNDPTRFAVRDVQGKSYHCCIGNPHLCSCRALQPCGHTLSVLLLFFKVSKGNPILWQSYINEVELIDLIEKRTEKEKCALCRERTGTMSFCEKCGSRFHQLCLKLAWKNGKGSHHTCPKCSEELPRSEGKGSSCCSNCNATCNAENYTCLLCPNYHLCRLCYESPKAHPSHPFGCSKMGSRALSTGGVVSHNVGDLQYREISPEDYDALLELDKGNRQPLGEEDLRNLPVEYFSARARKNQSCPVCLRAFLASSRCISLPCGHIMHHRCGYRWLSEFSDACPIDQQKAGRLRTMQDARAVGEAKASLQASTRHETTSQVPSAIVSFRLPAITPRERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H875</accession>
    <name>A0A836H875_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Vta1/callose synthase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_08079</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">LSCM4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VTA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000005">
        <property type="protein sequence ID" value="KAG5487634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065922.1">
        <property type="nucleotide sequence ID" value="XM_067209955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H875"/>
    <dbReference type="SMR" id="A0A836H875"/>
    <dbReference type="GeneID" id="92363889"/>
    <dbReference type="KEGG" id="loi:92363889"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.420">
        <property type="entry name" value="Immunoglobulin FC, subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.270">
        <property type="entry name" value="Vacuolar protein sorting-associated protein vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044538">
        <property type="entry name" value="Vta1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039431">
        <property type="entry name" value="Vta1/CALS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023175">
        <property type="entry name" value="Vta1/CALS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041212">
        <property type="entry name" value="Vta1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04652">
        <property type="entry name" value="Vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18097">
        <property type="entry name" value="Vta1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vta1/callose synthase N-terminal" evidence="10">
        <location>
            <begin position="19"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Vta1 C-terminal" evidence="11">
        <location>
            <begin position="329"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="207"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="245"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="268"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5487634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="39365" checksum="01373A25C8F2E11D" modified="2021-09-29" version="1">MISPASLLEKVPPAWAPMVRPFILRAQEFEDKEPLVAYFLCTHVAFLCMRQRKKEDKEGTAFLVTLLDALEASKTQLGAQLQGVDGRTVLTKYALMLFARADDAERMGNASMAIVRLFYAASVLFEATAQFTGDGATDSVAAQKSKYAKYIATLMKKALETKEPYVSPNKLESVDGEAGCGGSDANNAGQAATFTTAPASCFALPASRPASGSNRAPAPSATLGSTPPPYVPPPAYTYEEETRVSGKTSVQPPSMQNMYAPSQPQQPPQQHRQQLSNQNSPASQPPFSTSSRKQNPPRKSSPAQPLRHVAPPSADGGGVGATGFKPSVDQMIDAQKFASQAVSALQFYDYENAKQQLVGALRVLNGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H8X7</accession>
    <name>A0A836H8X7_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_05752</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063456.1">
        <property type="nucleotide sequence ID" value="XM_067207683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H8X7"/>
    <dbReference type="SMR" id="A0A836H8X7"/>
    <dbReference type="GeneID" id="92361617"/>
    <dbReference type="KEGG" id="loi:92361617"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="164"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="10"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="212"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5479745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="276" mass="29716" checksum="6D4F118AC3DD2D3E" modified="2021-09-29" version="1">MSTNSEQHWRRQLAQLEAEYEQIIQGLRDEVERQQRRCGELVHEQAMQRATAAADIRDFCQHYVTNAKQQQQQARPGATAPRMPQSARKSVDHIPLPALLTFLHEYSHGLLQLPENRRKRLRPDTQLSPLHHRLHQRMLARHRQTGREDELIDEWCSGEYGDGSGVAPPSMPPLSASCSSTWPAVRPRHADPEGRRHTAPASGGSTPGGDGLISSGRSSGSTGSSRRTLTTLSAGGAAAPIGKASAAAGSAAINSGGEGGPVMAASAFGLPSLPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H9P8</accession>
    <name>A0A836H9P8_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_02000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061074.1">
        <property type="nucleotide sequence ID" value="XM_067204037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H9P8"/>
    <dbReference type="SMR" id="A0A836H9P8"/>
    <dbReference type="GeneID" id="92357971"/>
    <dbReference type="KEGG" id="loi:92357971"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5472678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="123" mass="14254" checksum="C182CBB5091DFB3E" modified="2021-09-29" version="1">MSAPEWAKDEQTIEAAKSYLREGGAVDFFEMISRCILQQHPKNLVEFSLKIVTDILSGVEIPPEVDFEPKRVEDDQYMREKSVSNFLDEWVLALLRERPCSDLERMQFHKRYLEGLQSDSSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HD29</accession>
    <name>A0A836HD29_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidyl-prolyl cis-trans isomerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_01797</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000022">
        <property type="protein sequence ID" value="KAG5479208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063301.1">
        <property type="nucleotide sequence ID" value="XM_067203842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HD29"/>
    <dbReference type="SMR" id="A0A836HD29"/>
    <dbReference type="GeneID" id="92357776"/>
    <dbReference type="KEGG" id="loi:92357776"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000019">
        <property type="entry name" value="Nuclear inhibitor of protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050923">
        <property type="entry name" value="Cell_Proc_Reg/RNA_Proc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23308">
        <property type="entry name" value="NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00639">
        <property type="entry name" value="Rotamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="FHA" evidence="3">
        <location>
            <begin position="95"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="PpiC" evidence="4">
        <location>
            <begin position="312"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="170"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="182"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5479208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="439" mass="46626" checksum="71D3B0684BF95E9F" modified="2021-09-29" version="1">MSSFQAQVAKLTRAAETVSADAGQGLPAVAIPLSEAAQSLPPHIIAATDPVKLNKQAVIFRCPAWAGLPSRSFHLHCVRGKVPYPALGLQRFPYYLFGKNPVCDYVLEHPSISSVHAALIFNKEHACFVLLDLGSTNGVRLEGKRVETRKPIPITLGAVMQFGYSTRTYELRAGAPPPPLKRTREGGDEGPATRRHESGSTATESGHHGADEAPLSTAGAGCATCPVPAASTVVTLGTSASAGSPPRAENQMASEPPSLASVKASTIDAHGVRTVTPGRTGEAAPTTVLQATADATGVSETQAVTTSGEAECTPIHLFQLVIKHKDVENPVSRGHNRGELITRSRADALDMARCILADHQRRVPVVPELGFSPWTAEEFVAAVNECCEVSSKKKRGDLGMVERGTFADEIDEAAFRLRRGEVSAPVETRLGVHLLYRCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HDU5</accession>
    <name>A0A836HDU5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL15/eL18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_07888</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">LSCM4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000013">
        <property type="protein sequence ID" value="KAG5484322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064815.1">
        <property type="nucleotide sequence ID" value="XM_067209765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HDU5"/>
    <dbReference type="SMR" id="A0A836HDU5"/>
    <dbReference type="GeneID" id="92363699"/>
    <dbReference type="KEGG" id="loi:92363699"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.100.10.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000039">
        <property type="entry name" value="Ribosomal_eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17135">
        <property type="entry name" value="Ribosomal_L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="6">
        <location>
            <begin position="2"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="150"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="169"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5484322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="198" mass="22172" checksum="5552E25605B7C35A" modified="2021-09-29" version="1">MGVDLTGISKKSRVIRHHTYSTNPYIKLLIKLYKFLAKRTSSGFNKVVYQRLLKSRSNRAPISLSRIAVVMKRKSVFTEKNKKSPIAVVVGDVLDDVRMARIPAMRVCALRFSKSARQSILAAGGECLTFDQLAMMAPTGKNTYLMRGRKSGRESVRHFGASGVPGSHAKPHATNRGKETKRGRRPGQSYKRKAFRHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HE64</accession>
    <name>A0A836HE64_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063444.1">
        <property type="nucleotide sequence ID" value="XM_067207671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HE64"/>
    <dbReference type="GeneID" id="92361605"/>
    <dbReference type="KEGG" id="loi:92361605"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030217">
        <property type="entry name" value="NXF_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662:SF48">
        <property type="entry name" value="LEUCINE-RICH REPEAT PROTEIN (LRRP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5479733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1092" mass="120345" checksum="A00D0CD4B7B46392" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HE94</accession>
    <name>A0A836HE94_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_05146</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062419.1">
        <property type="nucleotide sequence ID" value="XM_067207116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HE94"/>
    <dbReference type="GeneID" id="92361050"/>
    <dbReference type="KEGG" id="loi:92361050"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5476186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="75" mass="8758" checksum="9EF1CEBCFAAA1F8E" modified="2021-09-29" version="1">MAGRNHKATTHSPYGLWVSAAAGVRLSVRHVRQAQEYSKQKIPQRLSEAVCELQLRPTFPFLHVRKRLWIPRLRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HFD1</accession>
    <name>A0A836HFD1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000020">
        <property type="protein sequence ID" value="KAG5480333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063664.1">
        <property type="nucleotide sequence ID" value="XM_067208024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HFD1"/>
    <dbReference type="GeneID" id="92361958"/>
    <dbReference type="KEGG" id="loi:92361958"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21203">
        <property type="entry name" value="ECM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032648249" description="Transmembrane protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5480333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="259" mass="28760" checksum="E96F4C86B6082437" modified="2021-09-29" version="1">MTSLWKTVSLLLTVLALVCSTSAHAALQSYVLERRVGSDGEWAEVGTFAISRLSSQALARISTQLRGEVSLSMDERNRFAAADLVYYRAYPYREGAPAPKHATTVVVTPCSLIRGFDAIDSKTVVLNEHIKIVPGPNTSLMGLQVSSETNFFHSKMQGGDECDRSVVQKLFPTVRLITKVGIVHPLKVARKVRYEDLAALAEEEKGTGEKPRAEKRQVRNAEGEIVEVEVPVDDRSFLQKYWMYFVIPIAMSVLQNMKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HFV1</accession>
    <name>A0A836HFV1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_06055</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000011">
        <property type="protein sequence ID" value="KAG5485417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065154.1">
        <property type="nucleotide sequence ID" value="XM_067207980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HFV1"/>
    <dbReference type="SMR" id="A0A836HFV1"/>
    <dbReference type="GeneID" id="92361914"/>
    <dbReference type="KEGG" id="loi:92361914"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03704">
        <property type="entry name" value="eRF3_C_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000144">
        <property type="entry name" value="Eukaryotic release factor 3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000020">
        <property type="entry name" value="Translation elongation factor EF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000204">
        <property type="entry name" value="Translation elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="324"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="109"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="130"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="256"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="284"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5485417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="763" mass="83536" checksum="AB1CEFCB98B932A6" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HG52</accession>
    <name>A0A836HG52_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_04439</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">LSCM4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062632.1">
        <property type="nucleotide sequence ID" value="XM_067206423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HG52"/>
    <dbReference type="SMR" id="A0A836HG52"/>
    <dbReference type="GeneID" id="92360357"/>
    <dbReference type="KEGG" id="loi:92360357"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097014">
        <property type="term" value="C:ciliary plasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000013">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF580">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="17"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5477221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="177" mass="18612" checksum="F30FFF976E18DE10" modified="2021-09-29" version="1">MSYKPFHATVPTNPQVWMEIEIGGKPAGRVTMELFADAVPKTAENFRALCTGEKGFGYAGCPFHRVIPEFMCQGGDFTNGNGTGGKSIYGSKFADESFAGKAGKHFGPGTLSMANAGPNTNGSQFFLCTAPTSWLDGKHVVFGQVLTGFDVVKAMEAVGSRSGTTSQPVRVSACGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HH32</accession>
    <name>A0A836HH32_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase III subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_06800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000009">
        <property type="protein sequence ID" value="KAG5486092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065423.1">
        <property type="nucleotide sequence ID" value="XM_067208712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HH32"/>
    <dbReference type="GeneID" id="92362646"/>
    <dbReference type="KEGG" id="loi:92362646"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5486092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="30417" checksum="158AFDD7DDD30E10" modified="2021-09-29" version="1">MFSSYILYDSVAIEAVYFPRHFTNECTGSSGAATTTIAQGTSSATTATAASGSDGDDEIYSLTMRDILLHRLTERYVGRVIPSRGLCVAITEVMDYSASSVRGAAASAWLTVTFGVCVFAPSRGTRLKARIAYQTAAGVYLTMDLFVAIPFLVPAELLVPGSRFSAAQGFWYLPLDAEEQEGGGHDAERNVDPAMAAVGVGSGKAPDTCGSDALVSSALASPTCVAAAPYNPYTVGAEVIVKVESCTVLSEEAVSAAEEASGAGAIHVMELRGSFVGDALGPMSWFEKDDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HHV7</accession>
    <name>A0A836HHV7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA-editing substrate-binding complex 6 protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_07430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000008">
        <property type="protein sequence ID" value="KAG5486497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065563.1">
        <property type="nucleotide sequence ID" value="XM_067209320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HHV7"/>
    <dbReference type="SMR" id="A0A836HHV7"/>
    <dbReference type="GeneID" id="92363254"/>
    <dbReference type="KEGG" id="loi:92363254"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035770">
        <property type="term" value="C:ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000963">
        <property type="term" value="P:mitochondrial RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044528">
        <property type="term" value="P:regulation of mitochondrial mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23735">
        <property type="entry name" value="RESC6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050870">
        <property type="entry name" value="FAST_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058917">
        <property type="entry name" value="RESC6_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21228">
        <property type="entry name" value="FAST LEU-RICH DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21228:SF71">
        <property type="entry name" value="MITOCHONDRIAL RNA BINDING COMPLEX 1 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26188">
        <property type="entry name" value="RESC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA-editing substrate-binding complex 6 protein" evidence="2">
        <location>
            <begin position="104"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5486497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="545" mass="60616" checksum="6ACB8F9EEC5D238E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HKQ7</accession>
    <name>A0A836HKQ7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar protein sorting-associated protein 35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_05763</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a role in vesicular protein sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the VPS35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063467.1">
        <property type="nucleotide sequence ID" value="XM_067207694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HKQ7"/>
    <dbReference type="SMR" id="A0A836HKQ7"/>
    <dbReference type="GeneID" id="92361628"/>
    <dbReference type="KEGG" id="loi:92361628"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030906">
        <property type="term" value="C:retromer, cargo-selective complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.660">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 35, helical subcomplex Vps35-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005378">
        <property type="entry name" value="Vps35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042491">
        <property type="entry name" value="Vps35_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11099:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11099">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03635">
        <property type="entry name" value="Vps35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009375">
        <property type="entry name" value="Retromer_Vps35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="255"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5479756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1009" mass="110863" checksum="8E6F4CEFDB6736EC" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HND6</accession>
    <name>A0A836HND6_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_05781</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063484.1">
        <property type="nucleotide sequence ID" value="XM_067207711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HND6"/>
    <dbReference type="GeneID" id="92361645"/>
    <dbReference type="KEGG" id="loi:92361645"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5479773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="641" mass="69923" checksum="39FCD5751DD76C66" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HTF5</accession>
    <name>A0A836HTF5_9TRYP</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_07767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000006">
        <property type="protein sequence ID" value="KAG5487278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065775.1">
        <property type="nucleotide sequence ID" value="XM_067209645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HTF5"/>
    <dbReference type="GeneID" id="92363579"/>
    <dbReference type="KEGG" id="loi:92363579"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="233"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5487278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="687" mass="72282" checksum="01D52217B0A8FFC3" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HWF8</accession>
    <name>A0A836HWF8_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_04963</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000014">
        <property type="protein sequence ID" value="KAG5483808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064747.1">
        <property type="nucleotide sequence ID" value="XM_067206938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HWF8"/>
    <dbReference type="GeneID" id="92360872"/>
    <dbReference type="KEGG" id="loi:92360872"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5483808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="365" mass="39030" checksum="C3F85302DB4F2232" modified="2021-09-29" version="1">MYNPALPNHYRDVVFAAYVRRRQREEEAAAQLQRNPNALASALSASSLAIPSILGASAPLLGLSAEELHQHRIKESAALGIQRAVTMEKEALEVEHKKRKLEGSDARSRISSRLDKLKALAAKSKAVAGAPTFVDTGDAALLPGNTLSPTSPHGTLSPSFAAEVVPSAPCAPLVFQRSSLAAGGYVMTTADRSHPSMLLRTATQSSVRGKPSSTLLLRFLHDSPLQGWSGAAIAEAATSSTEPPLCAPVLAQVQQLCRRFGFLRSIAARVYAEDVVLAAFARARSHTSGESVVPSAEEVRREQLRVWVRFDSVTEAFKATESLAKEISSAVPTAQPLFAVSFYPTGLYDANALELREEDLLPPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HWU6</accession>
    <name>A0A836HWU6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_07896</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">LSCM4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000013">
        <property type="protein sequence ID" value="KAG5484330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064823.1">
        <property type="nucleotide sequence ID" value="XM_067209773.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92363707"/>
    <dbReference type="KEGG" id="loi:92363707"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF18">
        <property type="entry name" value="D-IMPORTIN 7_RANBP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1134"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1150"/>
            <end position="1195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5484330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1330" mass="144211" checksum="602B764EECB27BCD" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HXH4</accession>
    <name>A0A836HXH4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-type lectin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_07899</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">LSCM4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000013">
        <property type="protein sequence ID" value="KAG5484333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064826.1">
        <property type="nucleotide sequence ID" value="XM_067209776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HXH4"/>
    <dbReference type="SMR" id="A0A836HXH4"/>
    <dbReference type="GeneID" id="92363710"/>
    <dbReference type="KEGG" id="loi:92363710"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005537">
        <property type="term" value="F:D-mannose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07308">
        <property type="entry name" value="lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051136">
        <property type="entry name" value="Intracellular_Lectin-GPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005052">
        <property type="entry name" value="Lectin_leg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223:SF28">
        <property type="entry name" value="LECTIN, MANNOSE BINDING 1 LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223">
        <property type="entry name" value="VESICULAR MANNOSE-BINDING LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03388">
        <property type="entry name" value="Lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51328">
        <property type="entry name" value="L_LECTIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="L-type lectin-like" evidence="8">
        <location>
            <begin position="55"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="310"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="332"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="446"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="489"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5484333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="506" mass="57402" checksum="F716830CE2095E12" modified="2021-09-29" version="1">MPHAHLAAQRKNRRRSWWWVAVCAAVVLAIGDGLFVAAYSRVPKLTPLQERRGITTAIGHHSFAPPLLRQYYGDGEIPHWSISGATVITDNYVRLTADRQSQTGHLWNTEPLDMDAFEVVVGFRVYQPMGGIGADGFAVWVAQPPRFDGPIFGRPSTFKGFGILFDSYDNDNRRDNPMVSLVYNDGSPTKRFDPDKDFMGDTVASCVYDYRAVTEPGMATMRMVYLKGTLQVFLSRDNEATEMECFRVTNLPMPADKAHLALSAETGGVSEIHDIVFVHLSPLAEATYDHDVRQTVLPTNELHDAQLYNNDAMNNRPPAVEPGVANSPTTTPQEMQQVPQQMQQAPQHQEQQVPQQMQQAPQHHEQQSQVPQQMQQAPQHQEQQVPQQMQQAPQHHEQQSQVPQQMQQAPQHQEQQVPQQMQQAPQHHEQQSQVPTQAFASAAATERQRIEELERKLAELQARDTRRVADRVEEEEAEEGLGNSDVSPRRVRRARTHHQNREERDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HY06</accession>
    <name>A0A836HY06_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_07344</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG5486416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneID" id="92363173"/>
    <dbReference type="KEGG" id="loi:92363173"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="250"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="337"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="716"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="541"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="352"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5486416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="751" mass="80090" checksum="75AD54405C5A6B09" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HZE7</accession>
    <name>A0A836HZE7_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06623</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000010">
        <property type="protein sequence ID" value="KAG5485665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065249.1">
        <property type="nucleotide sequence ID" value="XM_067208538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HZE7"/>
    <dbReference type="GeneID" id="92362472"/>
    <dbReference type="KEGG" id="loi:92362472"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="612"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="621"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5485665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="809" mass="87422" checksum="FA1A0350C4701650" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HZK1</accession>
    <name>A0A836HZK1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Condensin complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_07745</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CND2 (condensin subunit 2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000006">
        <property type="protein sequence ID" value="KAG5487256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065753.1">
        <property type="nucleotide sequence ID" value="XM_067209623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HZK1"/>
    <dbReference type="GeneID" id="92363557"/>
    <dbReference type="KEGG" id="loi:92363557"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022816">
        <property type="entry name" value="Condensin_barren_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13108">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13108:SF9">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05786">
        <property type="entry name" value="Cnd2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="192"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="307"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="381"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="455"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="611"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="787"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="859"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="917"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1000"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1037"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="381"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="395"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="797"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="859"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="879"/>
            <end position="888"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5487256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1146" mass="118792" checksum="79E47955A9FEB5A9" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836I2U2</accession>
    <name>A0A836I2U2_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_07820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000006">
        <property type="protein sequence ID" value="KAG5487330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="loi:92363631"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033045877" evidence="2">
        <location>
            <begin position="24"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5487330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="273" mass="29690" checksum="7D83C057DD00DF33" modified="2021-09-29" version="1">MSHIVMRALALILAIAAVPVITAVQSGHCPSLHSPPSYTFIGGGFHMQLALEYPLPAMEVRFSFDLPKSFFIDEAEAQQLYRMEVLSGNPMTQGMDAVVVAEITRAYTPLHMSSAYFFDIEAPVFKVNYTTNHVVLTFQQMTSKGAGSALDAYLAEDGAQAEASLRARLVIPIHSRYDVLDATSTFSLRRFITGEGSYVRRCLTKVDVAGRADPRCSAGTYSASATTATLGERPSYRPCLDLPVGLLDDLPRVYHALMSLLVAGAVIVILTIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836I3G4</accession>
    <name>A0A836I3G4_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_07777</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000006">
        <property type="protein sequence ID" value="KAG5487288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065785.1">
        <property type="nucleotide sequence ID" value="XM_067209655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836I3G4"/>
    <dbReference type="GeneID" id="92363589"/>
    <dbReference type="KEGG" id="loi:92363589"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5487288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="111" mass="11879" checksum="8F0F32A3B846A74A" modified="2021-09-29" version="1">MRLMEREACTMALLYLPRNASLWALSGTLADRIGSPAEAQDNMRVAIALAALEESAESGLAAKSRCGRPSPPAAASSLAADFPNVFKGITTEEPHSSRADLLRYARAFLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836K8Z4</accession>
    <name>A0A836K8Z4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HPP transmembrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_00767</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059491.1">
        <property type="nucleotide sequence ID" value="XM_067202841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836K8Z4"/>
    <dbReference type="GeneID" id="92356775"/>
    <dbReference type="KEGG" id="loi:92356775"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007065">
        <property type="entry name" value="HPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058581">
        <property type="entry name" value="TM_HPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33741">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN DDB_G0269096-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33741:SF5">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN DDB_G0269096-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04982">
        <property type="entry name" value="TM_HPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="252"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="HPP transmembrane region" evidence="3">
        <location>
            <begin position="121"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5467689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="287" mass="31068" checksum="D5FA5C40D5D15468" modified="2021-09-29" version="1">MNEWSGGDDGAVDPPRAESCVLVSSGGMQLSYPAGSDRSMHEMRSEELQDHADASQAVHASDSDLANKETSAGETADAKGEEEPLRRRLSVSCFLGWYWSRLTGYDQSLNAYGIYPSWDQLIALTFTCFTLILLGLIEHYGIHPLLNHTLSVFFPAIGSSCTLVYAAPKAPMAQPRNIIVAHVTAAIIGTALANAFRTVKEQPFGHHCAGALGVGLHLVLMMLTNTMHPPASATVITAATAKMNAYYHDEGFLFVVSPVLFGSVFTTLCACLLNNLVPSRSPYPQYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KBQ2</accession>
    <name>A0A836KBQ2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">carnosine N-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_00865</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnosine N-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.22" evidence="2"/>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059583.1">
        <property type="nucleotide sequence ID" value="XM_067202933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KBQ2"/>
    <dbReference type="SMR" id="A0A836KBQ2"/>
    <dbReference type="GeneID" id="92356867"/>
    <dbReference type="KEGG" id="loi:92356867"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030735">
        <property type="term" value="F:carnosine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012901">
        <property type="entry name" value="CARME"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303">
        <property type="entry name" value="CARNOSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303:SF6">
        <property type="entry name" value="CARNOSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07942">
        <property type="entry name" value="CARME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01296">
        <property type="entry name" value="N2227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5467781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="456" mass="51551" checksum="13631B4EAB154E97" modified="2021-09-29" version="1">MSAEEGEARSEGSKGASAAPPSCAPHSISIELNDFPGYEHQGVPPPPYSMESAIHQQVPLYQPHAPVPGTVIDPDMVEDHISFLRTVRAFHNYKHQALAAREMRCTNFRKLQDKHRDLLCIDLDKILDKYLECIEVNSTFFEAICEASEELFDSYWPEGTTVLMEEVPPPTPLDMNKVFSTLRQFVRDWSAEGVAERDCVYKPILDTLDRYFPDRSERENVRVLIPGAGLCRLSVELALRGFFAQANEFSYHMLIAGHYIQNHVLESCQHKIYPYSDSTCNLVNRADQFAEVQIPDLCASEAIDALRDESLSFGQLSMVAGDFTEVYAKPHQHKTWSVVATCFFIDTAHNIIEYLEIIYNLLVPGGYWVNVGPLLYHFADSTDDMSIELSLGEVLTVAQRIGFVLNGPPSFIDTTYTNNQRSMKQLVYRCAFFVLQRPLDDTKKEQKDCDAVVKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KD30</accession>
    <name>A0A836KD30_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_01064</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059779.1">
        <property type="nucleotide sequence ID" value="XM_067203129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KD30"/>
    <dbReference type="SMR" id="A0A836KD30"/>
    <dbReference type="GeneID" id="92357063"/>
    <dbReference type="KEGG" id="loi:92357063"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5467977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="151" mass="17722" checksum="6F4AC800D9A3052C" modified="2021-09-29" version="1">MTLSSSGSAALVDSALRATSAAAPQWTAQQRCFRQLMKSLRGAYFHDRSKLFWARHRVLVEFYKYSRVEEEKDVLLLIGIGNEIAHFVGEYMKVDVGAIMDHNEKMQSLPVARAKRYREEYLLHEKQHESWCKQKIRLMMDRRPPPPYPFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KF89</accession>
    <name>A0A836KF89_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060933.1">
        <property type="nucleotide sequence ID" value="XM_067205381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KF89"/>
    <dbReference type="GeneID" id="92359315"/>
    <dbReference type="KEGG" id="loi:92359315"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="540"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5471816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="578" mass="60763" checksum="D34C2D0F6BFE9BA1" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KGN3</accession>
    <name>A0A836KGN3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_00317</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058504.1">
        <property type="nucleotide sequence ID" value="XM_067202403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KGN3"/>
    <dbReference type="SMR" id="A0A836KGN3"/>
    <dbReference type="GeneID" id="92356337"/>
    <dbReference type="KEGG" id="loi:92356337"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5464873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="171" mass="19461" checksum="29A290CF363E659A" modified="2021-09-29" version="1">MWGLSITKVFRAYCAGAALFEVPMIVKLLRGDMPLPKAGSWVDDKDYYRNNKPLVYVFVAILACLVVSRGMACALPKSRIVIAYLVVVHMIEAGLYLYCCRHKEDAPNNSVYIFGALMVLNICLFAARLVQLKVQHARAEANNLKRRQEQLDVIRKKRADYAKSKEEKKNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KHH3</accession>
    <name>A0A836KHH3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">V-ATPase proteolipid subunit C-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_02298</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061368.1">
        <property type="nucleotide sequence ID" value="XM_067204331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KHH3"/>
    <dbReference type="SMR" id="A0A836KHH3"/>
    <dbReference type="GeneID" id="92358265"/>
    <dbReference type="KEGG" id="loi:92358265"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18177">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6F_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18178">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6F_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000002">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="VACATPASE"/>
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        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
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            <begin position="158"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5472972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="224" mass="22962" checksum="6160B0FE66F91B62" modified="2021-09-29" version="1">MPVEAEVLPMPTRLPPDDAMHVVGSVIRYILVIVVVLFGIIPALCGTVFPPFSALWSILAAVSPYAWASMGTGIGIALSILGAAWGILTSGASISGAAIRAPEIRSKNLISIIFCEAVAIYGVILSIIMMGKIQASNSSVVRDGAYSYETVAGGYTLFAAGVAVGIGNMACGIAVGIVGSSCAIADAHSSSLFVKVLVIEIFASALGIFAVITGILMAQKVQMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KIK0</accession>
    <name>A0A836KIK0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_04133</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062059.1">
        <property type="nucleotide sequence ID" value="XM_067206122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KIK0"/>
    <dbReference type="GeneID" id="92360056"/>
    <dbReference type="KEGG" id="loi:92360056"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="374"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="421"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5475551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="485" mass="53007" checksum="B98D36D26193F0EE" modified="2021-09-29" version="1">MLRYHKASPVRYPPVSAYSTPPPSPPPSTFNHSSAMQTRQAKGGVNTSSILQELPSEVLIPTLLLLVLSSVTVTAVNGVFNILAQKDRMVMETFQQWRRVLWMSRAAHIVEAPSAEQAHRMTQTHHAAAVTASPTPAMPSVELYNSAAFFRGISASTGATAPPAGVEASSATDVVIVDLRGGGLAATSPRARSVTPEVGNAEGRAEMRMYHEENPPAAVPAPVVAEVLTNTMEAVRRESQRVIFTFHPYYIILCAIKGFAMLIYIQYHFGSIKGGWRRFCVCGAANVFSGLLTPVWEYTMMMLLPLDVDRATPVVVKEEEKADSVFIVELLLRISRLELNDLPTVLMQGTTFVGFAAVLMPLFGVFCSSGLVRYLWIYAPLWLVYVVVRHVYYKGAGSPPSSRARNAAAVVGMTNEMLKAFLMKALTVLVLLFTIQSSFLLGLAWAEGAAYDKGLQYMAEHELGFHAGAFVSPFQKVCLLSQLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KKR1</accession>
    <name>A0A836KKR1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_01861</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
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            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000022">
        <property type="protein sequence ID" value="KAG5479269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067203903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KKR1"/>
    <dbReference type="SMR" id="A0A836KKR1"/>
    <dbReference type="GeneID" id="92357837"/>
    <dbReference type="KEGG" id="loi:92357837"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF91">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PLK4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="75"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="261"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="577"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="772"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="797"/>
            <end position="807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5479269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="987" mass="105076" checksum="40435461BEBB9B1E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KL73</accession>
    <name>A0A836KL73_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_04648</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000023">
        <property type="protein sequence ID" value="KAG5478416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063077.1">
        <property type="nucleotide sequence ID" value="XM_067206630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KL73"/>
    <dbReference type="GeneID" id="92360564"/>
    <dbReference type="KEGG" id="loi:92360564"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5478416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="370" mass="39194" checksum="14688747CA785CB1" modified="2021-09-29" version="1">MSCLPTQHTLDEVELLVQELQLRMTRTVEVSPRLRASLQEPHVLYTILAEFFDSQRTQAQRAKDVSLDAADARRVWAFCVEELTSSCATHSRSTPTAAAPSPGELSDAKAPAQTLHEFVHDAPSLPLEALQRVAPVVHGNSLLCTPSAAVAFSSSCSSSGGASPTSVFSILRPAFARLMDLAYVADQRLQRPSSSATISVLSLAALAASLVPTLDRVQAMRLTAQMADDLVHGCPVSSDGSATPPYSRSAVATLLAGVWYVWGVLDSAHSKALHLLGGRLFQQFAPPTRGPVASDLSIFSFTAWVQRALRENHGALHQQLYADAPSDCPPANAGTGGVDAIVAPSADECDTTAASEGIAADPDFWARLAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KMV2</accession>
    <name>A0A836KMV2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_03142</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">LSCM4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060710.1">
        <property type="nucleotide sequence ID" value="XM_067205158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KMV2"/>
    <dbReference type="GeneID" id="92359092"/>
    <dbReference type="KEGG" id="loi:92359092"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="6">
        <location>
            <begin position="122"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5471593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="274" mass="31207" checksum="3EA6C4BB67858845" modified="2021-09-29" version="1">MESLYAKVASFDMETLTSAQRCGVEAAFLGIIFAGFGVYDHVIVPAIAVVVKGRIPERVKPLAKLSVKDKVYIGFAKAVTAAFVYHTYQFIRNTKVSRMSPSFLDGPAVARSLLWLPVHLPALFIIYDFFYTLFHWALHWPPIYPLIHKHHHRQMSPFRGNTDAINDNPVEYVSGEYLHLLALYLLTRITPLGQVHALTAVMFILIGGTLASLNHTRVDLRIPYVFNVKAHDYHHRQPRVNFGQYIMLWDWVFGTFQAEGLPSEESARNRKKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KNF8</accession>
    <name>A0A836KNF8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000017">
        <property type="protein sequence ID" value="KAG5481864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064224.1">
        <property type="nucleotide sequence ID" value="XM_067208850.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92362784"/>
    <dbReference type="KEGG" id="loi:92362784"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="772"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1215"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1266"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="231"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="462"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="537"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="554"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="785"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1217"/>
            <end position="1230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5481864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1660" mass="173186" checksum="9DADD6B9E90EA90F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KP68</accession>
    <name>A0A836KP68_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RWD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_06133</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000020">
        <property type="protein sequence ID" value="KAG5480367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063698.1">
        <property type="nucleotide sequence ID" value="XM_067208058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KP68"/>
    <dbReference type="SMR" id="A0A836KP68"/>
    <dbReference type="GeneID" id="92361992"/>
    <dbReference type="KEGG" id="loi:92361992"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="CDD" id="cd11605">
        <property type="entry name" value="RWD_DRWD_ELF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000115">
        <property type="entry name" value="RWD domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040213">
        <property type="entry name" value="GIR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12292">
        <property type="entry name" value="RWD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RWD" evidence="2">
        <location>
            <begin position="10"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5480367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="232" mass="25945" checksum="23D23624D46A4558" modified="2021-09-29" version="1">MPLATEMQEMEMEMVQGMYDTYEHLSDDPPSYCVSLAATEEEPPQLKVIITYPTEDYPESAPCVVTVECIAKARRIQVGAITKQIATTCEENIGMHSAVLVLQQVQEFLSRAFEEEEKADLLRRGEAIAAEAAKRTGAVEVDPTIRLGTAVTRELFEEWSRKHHAEKAKARAEREKKDVKVSASKLSGRQLWDNSLKTADWALFGGEAEEDGGEDVDFGSIKDLDEDEFDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KPC7</accession>
    <name>A0A836KPC7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mak10 subunit, NatC N(Alpha)-terminal acetyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_06943</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000013">
        <property type="protein sequence ID" value="KAG5484296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064789.1">
        <property type="nucleotide sequence ID" value="XM_067209739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KRL2"/>
    <dbReference type="GeneID" id="92363673"/>
    <dbReference type="KEGG" id="loi:92363673"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00065">
        <property type="entry name" value="FYVE_like_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47523">
        <property type="entry name" value="F21O3.11 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47523:SF1">
        <property type="entry name" value="F21O3.11 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="93"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="537"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="537"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5484296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="807" mass="87499" checksum="18B9AC4556FFDF7A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KRM5</accession>
    <name>A0A836KRM5_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_07697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
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            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000012">
        <property type="protein sequence ID" value="KAG5484924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065036.1">
        <property type="nucleotide sequence ID" value="XM_067209576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KRM5"/>
    <dbReference type="GeneID" id="92363510"/>
    <dbReference type="KEGG" id="loi:92363510"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="429"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5484924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="443" mass="47939" checksum="F40DC409E51C2586" modified="2021-09-29" version="1">MTTSRGGDLDSICSLSSSENSPRGRGQPNERLLDLLTRPPERGGYGGRLNYAGFATLAASLGWNQEDMDDCWYDIVMGEPCAEAVDMTRVAECVCSYCLASPLPILERHTNAQLIAAEPATPSRPKHSSKEPSTTVLLSPPTPPPCVVEALAPIIPEVGKAERARAAAPSPPLASPPLASPPRRRIDANAFPRYAVKTVSSEQKKTRVQPRHQSHRGQGGPRAAHSPRRASPAPAAPRVSRHAGDTVFFRLYEEGMEQQRRRASVKPVEEATTECTFQPHITPHATKVPDTKSVQYNRPTLSYFAKLTGQETRQDAEGGAPETPRVTYHPAPGPSSSVPTGYVEGVARLRGYIASRYAHASFEKSLRGKPLTDVASLVEAPILRLPVTVGGVTDSVDVRLASPQTHTSLGRRRTASREHLSSRQRGEGRPTSSPSPSRARFHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KRQ5</accession>
    <name>A0A836KRQ5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_07998</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">LSCM4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAFHLR010000013">
        <property type="protein sequence ID" value="KAG5484431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064924.1">
        <property type="nucleotide sequence ID" value="XM_067209874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KRQ5"/>
    <dbReference type="GeneID" id="92363808"/>
    <dbReference type="KEGG" id="loi:92363808"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000405">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="52"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5484431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="579" mass="64384" checksum="68DF9208233BBEA0" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KS80</accession>
    <name>A0A836KS80_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_04864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="596"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="622"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="7">
        <location>
            <begin position="411"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="147"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="257"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5486832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="649" mass="70549" checksum="58A689DBF6471A8E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KWQ3</accession>
    <name>A0A836KWQ3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Core Histone H2A/H2B/H3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_06633</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histone H3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000010">
        <property type="protein sequence ID" value="KAG5485675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065259.1">
        <property type="nucleotide sequence ID" value="XM_067208548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KWQ3"/>
    <dbReference type="SMR" id="A0A836KWQ3"/>
    <dbReference type="GeneID" id="92362482"/>
    <dbReference type="KEGG" id="loi:92362482"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000077">
        <property type="entry name" value="Histone H3 variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="3">
        <location>
            <begin position="100"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5485675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="192" mass="21198" checksum="0A1C0092B9D64D38" modified="2021-09-29" version="1">MAPLWPLHSSPSNCTRSAGDAFTRPPHLPILTTLSSPAYAPKPPQSPQPFTHLPPSHPPPATMSRTKETARAKRTITSKKSKKAPSAASGVKKAHRRWRPGTCAIREIRKFQKSTSLLIQCAPFQRLVREVSSSQKEGLRFQSSAIMAIQEATEAYIVSLLADTNLACIHAKRVTIQPKDVQLALRLRGERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KX06</accession>
    <name>A0A836KX06_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ankyrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_06726</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000009">
        <property type="protein sequence ID" value="KAG5486020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065351.1">
        <property type="nucleotide sequence ID" value="XM_067208640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KX06"/>
    <dbReference type="SMR" id="A0A836KX06"/>
    <dbReference type="GeneID" id="92362574"/>
    <dbReference type="KEGG" id="loi:92362574"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="155"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5486020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="22520" checksum="BDECC0E38062FD6E" modified="2021-09-29" version="1">MSVMAAASSTGPSPYPNALQSRQTTAEQRQIAAAAVLAYRDTLEQEKVLLVENGALLSEDEAKRLQHRVDDQAAANATAAQLRDHACEVVASVQDDERREEGCAIDIFHAACDGDVAALDACVQSGVSINAIGQPDPARYNGVQFKQRWLFRAPPLVFAAAFGREEAVRFLLAHGADPHATSTTGLRALDYAVGRDYDAIVRMLTSGVPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KX29</accession>
    <name>A0A836KX29_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_06803</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000009">
        <property type="protein sequence ID" value="KAG5486095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065426.1">
        <property type="nucleotide sequence ID" value="XM_067208715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KX29"/>
    <dbReference type="SMR" id="A0A836KX29"/>
    <dbReference type="GeneID" id="92362649"/>
    <dbReference type="KEGG" id="loi:92362649"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="76"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5486095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="282" mass="30934" checksum="B52A95A88F045477" modified="2021-09-29" version="1">MEKSADARSSQHDGSSAAPATAQRESSPMAAMPTNTALTTAPGKGRKSAFLARSPSGSPLPSVELDEATIALIKENEQMLQTIAALQHELDKQQVRLHDVEGARASLAEEVAELRSQLGLATSEVTTSTGKVLNYKTAFTDLQHAFDQLKKDSDATKEKLEEATQRERLLMQGASNTARQQSHMKESFDLVTLAMRMPNSFLVSIRRIMEKLNDPALRPADRQRKLKVDIDRLEAQVTAYKPDTSLVAGSVDSVPNVDIPIRQCVYAFLTVIMTLLKNEVCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KX40</accession>
    <name>A0A836KX40_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_06833</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000009">
        <property type="protein sequence ID" value="KAG5486125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065456.1">
        <property type="nucleotide sequence ID" value="XM_067208745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KX40"/>
    <dbReference type="GeneID" id="92362679"/>
    <dbReference type="KEGG" id="loi:92362679"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5486125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="531" mass="57655" checksum="6A10CB1BDD5D4B46" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G1T4</accession>
    <name>A0A836G1T4_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059136.1">
        <property type="nucleotide sequence ID" value="XM_067203445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G1T4"/>
    <dbReference type="GeneID" id="92357379"/>
    <dbReference type="KEGG" id="loi:92357379"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5466246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="504" mass="54136" checksum="B0064D8B270D4D43" modified="2021-09-29" version="1">MSTLKPSAPLLSPPPNGASPSTALDDLKLQFATEEVRKRFSAISMTDMLAVLSMLLTDPRIRECAREQTSGALKVGIHGLPFALELKRSDVSACGGRNSASRVRQPASVRSFTTAKLSPQDWCTRSLEMSEAPTLHAPAASWLSQEWTTTITSILDNASQHCEFTDEHCTVVERVQLSIKEWFEDASVEAVEREKVHAATDSDAYEDPAWLSTLTQVRHLAEAACYSKYAAVYQRLCSEAEDESDEGMATPAYVQRDDDSAKAPSSVMARWSAHRAATGPVGIPPFSLVIQCGSGGGGAGASTPSLNFDLEARNGGTRGSGLDSSGASFVVGCEWFQWVFLVQSLLTCQSAPYPGLEGGAADRDAEALAAEQEKWQQRHCTVQLLYPSEAGFSDGSDGSSGLRSAEAEYELSEPHIVLSSLLGVAMRVWCQSHPHIVAHVLQLEEDTYPRHIYDGSLFWSVWPLSDSAVLDQCECTAASGSMPIPLLPGECFAHELGSGGGGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G211</accession>
    <name>A0A836G211_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_01516</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059256.1">
        <property type="nucleotide sequence ID" value="XM_067203565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G211"/>
    <dbReference type="SMR" id="A0A836G211"/>
    <dbReference type="GeneID" id="92357499"/>
    <dbReference type="KEGG" id="loi:92357499"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000012">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000004">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000129">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001679">
        <property type="entry name" value="PRK00440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF9">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="49"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5466366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="364" mass="39795" checksum="35F582BDE2AAB5C5" modified="2021-09-29" version="1">MYAGRQGDEAKAAASHLPWVEKYRPSTLESVVAHEDILSTLRHLMDSGNMPHLLLYGPPGTGKTTTIKACAHYLYGKDRVRANVLEMNASDDRGIDVVRHQTREFASTSSIFSMVGSSSSVGSGSSGPAAKFKLVILDEADQMSHDAQAALRRVIEKYTRNVRFCILCNHINKIIPALQSRCTRFRFAPVKKSAMMPRLRYVAEQEGVHYTADGLAAAFRLSHGDLRRCLNTMQSSALSADEITEESVYRVTGNPTPADVTAIVSDMLSSDFATGWIKVEETVMQKGISMADLTREIHPVVMAMDLPQDCKCFLLVKLSDLEYYAAGGARESAGLGGLLGAFQLVKEAVTQRKPIRDVAEGCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G3R6</accession>
    <name>A0A836G3R6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_00225</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058415.1">
        <property type="nucleotide sequence ID" value="XM_067202314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G3R6"/>
    <dbReference type="SMR" id="A0A836G3R6"/>
    <dbReference type="GeneID" id="92356248"/>
    <dbReference type="KEGG" id="loi:92356248"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="8">
        <location>
            <begin position="40"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5464784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="268" mass="30241" checksum="DA405FE04C4B7DF4" modified="2021-09-29" version="1">MRSPSNGGARVHWGLRGFPRQVFYLVALAAALQSTTLAHALFYNFIDGTPLCFSEVIENVEGSQITGVYNWVANPMSPPSNVLLRLSVKDGAGNVYYDKEMMEGEHPFTVQLNPNVLSGEQLICFTASSKFVAPNERPVKVLIELDQELKKGFNADKEVVETIQKRRQIDGLDVYTYQDAGGELKDILQPRAYLETIERELNAMNWLLVQLTDSLGTSAQRESRMRTTTESTFTRVWVCSLLLIGIISGVLWMQFRFLKSTLRKKKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G4J0</accession>
    <name>A0A836G4J0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_00937</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059653.1">
        <property type="nucleotide sequence ID" value="XM_067203003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G4J0"/>
    <dbReference type="GeneID" id="92356937"/>
    <dbReference type="KEGG" id="loi:92356937"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5467851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="35934" checksum="6B96173E1820A326" modified="2021-09-29" version="1">MSLWPFRTGNDERFQTSSGFSSTEDIYAAARQGPLPPHRYEVEVDNYLEWRWRRGFVQSVFPVMCYGAVAGFCVGFRQSRVEGRYIGRYRIMWRYTSTFSAVGLLTSAFHHLLVVRNRYHDTFYYPVVSGAAGAVVLSLASQMGNIGQSMFAGAFLGILYGVGCHGMAYYHRRRLRAFLHEQQLQQVPIHKVSPELQPMYRAFLYDNRPLEEKDKQSREAVTLSRSVDDTRLDAHTFMSNMTPEVFDWVNFPDWWPFKWPIQTEEEQLLLERQRNDEIERRKKLILETEDGGLLKRKNRAKEYRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G692</accession>
    <name>A0A836G692_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Iron-sulfur assembly protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_01307</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HesB/IscA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059054.1">
        <property type="nucleotide sequence ID" value="XM_067203363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G692"/>
    <dbReference type="GeneID" id="92357297"/>
    <dbReference type="KEGG" id="loi:92357297"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.300.12:FF:000013">
        <property type="entry name" value="Iron-sulfur assembly protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43011">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43011:SF1">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="168"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="172"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5466164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="221" mass="23447" checksum="D70D8323B2C35571" modified="2021-09-29" version="1">MLRLSLRRWCAAAVGGASTSGAHGSTPGTKLPDFYGKSFSVSPRAWAQITRKNSEEGFTNDVRYLRLAVDSGGCHGYLYKFSFETNSEFNREEDVAIAESDAVSPSDEAFTGAQPSPRVVVDTLSVSKLENARLDYHSELKGSAFVVVGNELVDESCACAMSFSMRKKTRPSKSPSSGAKGASSGDDGSRRGSDATAPSAGSFSVANARPISRYSTTRATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G6J2</accession>
    <name>A0A836G6J2_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_05116</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067207087.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="loi:92361021"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033048740" evidence="2">
        <location>
            <begin position="21"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5476157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="400" mass="42304" checksum="4FBE54C3E5DE1FE9" modified="2021-09-29" version="1">MIARTLSRLCARWPAALVAATGCLPASDVGVPAWNAFFDALQLQEESHGRETGTSGYMRFDAVPAPLLRSIAQQWTDNALLAVTSARLAEVCPPAHASALRGACEAAESPLSSSSPPDGLELLLATWSAHMLLSGLHASHQASFAVSPHMIRSYSYTAPDTVSAVLADCLKKDVVPVLRYLTEFATPPASTLVSQQPHCLPSSTRALRHALVLLLSSFVATWREAPSSKAQSPPRSMILSKQERALALELRRCIDACGGSRTTAESIVGRERRGDASAQAHSRDAGGKATRLRVTSLEATTEAQLALVQAALADMMDPDDSSVASTNVDTKDPETGDGPLWRACEAWITGAGPSAPSSPFAGITQTGEKESETVDVLQRVNSQLSQIARRSAVKTGSGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836G974_9TRYP</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_00883</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059601.1">
        <property type="nucleotide sequence ID" value="XM_067202951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G974"/>
    <dbReference type="GeneID" id="92356885"/>
    <dbReference type="KEGG" id="loi:92356885"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="401"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5467799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="629" mass="66807" checksum="179F8A88BF778715" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GBH1</accession>
    <name>A0A836GBH1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">guanylate kinase</fullName>
            <ecNumber evidence="2">2.7.4.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_02424</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the guanylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.8" evidence="2"/>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060006.1">
        <property type="nucleotide sequence ID" value="XM_067204454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GBH1"/>
    <dbReference type="SMR" id="A0A836GBH1"/>
    <dbReference type="GeneID" id="92358388"/>
    <dbReference type="KEGG" id="loi:92358388"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:GMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.63.10:FF:000002">
        <property type="entry name" value="Guanylate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000776">
        <property type="entry name" value="Guanylate kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017665">
        <property type="entry name" value="Guanylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03263">
        <property type="entry name" value="guanyl_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117">
        <property type="entry name" value="GUANYLATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117:SF17">
        <property type="entry name" value="KINASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="7">
        <location>
            <begin position="5"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5469029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="203" mass="22940" checksum="7348782DDAC85B7C" modified="2021-09-29" version="1">MNKPLNALVVCGPSGVGKGTLLGRLLREYPNRFAYSVSHTTRKPRQGEVDGREYHFTDRESILKMRDNNEFLELCDVHGNFYGTSVAAVHAVQKQGKVCIIEIDVKGAQKLFGRTDSALNAVYFFIMAPKDELRKRIMKRGADDEAMLQRRLETAESEYKFLEEHPDFFSVLLVNDELETAYAGLVAAIDDQLVKHNMEKLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GCZ2</accession>
    <name>A0A836GCZ2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Rac serine-threonine kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LSCM4_02003</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061077.1">
        <property type="nucleotide sequence ID" value="XM_067204040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GCZ2"/>
    <dbReference type="SMR" id="A0A836GCZ2"/>
    <dbReference type="GeneID" id="92357974"/>
    <dbReference type="KEGG" id="loi:92357974"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05123">
        <property type="entry name" value="STKc_AGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000008">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045270">
        <property type="entry name" value="STKc_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PH" evidence="10">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="106"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="12">
        <location>
            <begin position="360"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="414"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="414"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="443"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="500"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG5472681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="510" mass="57775" checksum="4454306A192E9F69" modified="2021-09-29" version="1">MSGYLKVLSQDGNWESRYVEIDDTKLRFWRTKADKESGAVVVKELDLKCATLREVSEPNTWAVQPEKAEATYFQADGEERKTEWMDTLRHYNSSSSKSEKVTLRDFEKKFVLGKGSYGKVFMVVKKDTEKWYAMKEMSAEKMRQAEIKAPFAERIILEEIDHPFIVHLHYSFQEQGNLYMILDLLAGGELFTYIEQHAPLDEEVVKFYAAEVALALGYLHSRNIIYRDLKPENVVFDRDGHACLTDFGLAKANVHEPNAVTYCGTNEYLAPELLKGVPHGKAVDWWSLGLMMCEMLFNDLPFYDENPMQMQMKILTEEVSFPPHIEISEETKDLIRCLLNKNPERRLQTLEEFKAHKCFSNLDFDLLEARKLKAPITPDPDPAHNFAKEFTSEVIVQNESPSQAVVTLAGYTYDRDSSEQEKSPSHSPTTAEELRQRRASKRAFSNGSDAASSPVTRAEGMSNFSAAGGPSKQAATGPVKKVEYHIPAKVAPQAARKKLTGSNSSDKPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GCZ6</accession>
    <name>A0A836GCZ6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Small acidic protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_00375</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058558.1">
        <property type="nucleotide sequence ID" value="XM_067202457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GCZ6"/>
    <dbReference type="SMR" id="A0A836GCZ6"/>
    <dbReference type="GeneID" id="92356391"/>
    <dbReference type="KEGG" id="loi:92356391"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026714">
        <property type="entry name" value="SMAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028124">
        <property type="entry name" value="SMAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22175:SF0">
        <property type="entry name" value="SMALL ACIDIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22175">
        <property type="entry name" value="SMALL ACIDIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15477">
        <property type="entry name" value="SMAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small acidic protein-like" evidence="4">
        <location>
            <begin position="137"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="88"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="109"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5464927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="209" mass="22689" checksum="868274EDB9DD6742" modified="2021-09-29" version="1">MSSFKDCLREVREAAMEHLERYRGGDPEKALQHTPREEALATISLISVRLLEQELKKCGAGDSASLHELHAHLKVCRKALRSFIARSAAGGEGASDKKRRRTEEDTEAPTPSSSSRGTAAAEQSRTSTPLHLGQYASSDAFDQNEQKRMKFARLMGGAKVAAQEHVSAGGHAHHNTSVASKVELQRMNANLESQFDSAMSHKGKKGLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GDH3</accession>
    <name>A0A836GDH3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1</fullName>
            <ecNumber evidence="1 11">2.1.1.57</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 11">Cap1 2'O-ribose methyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LSCM4_00712</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10 11">S-adenosyl-L-methionine-dependent methyltransferase that mediates RNA cap1 2'-O-ribose methylation to the 5'-cap structure of RNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA to produce m(7)GpppNmp (cap1).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside) in mRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67020"/>
            <dbReference type="Rhea" id="RHEA-COMP:17167"/>
            <dbReference type="Rhea" id="RHEA-COMP:17168"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:167609"/>
            <dbReference type="EC" id="2.1.1.57"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.57" evidence="1 11"/>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058888.1">
        <property type="nucleotide sequence ID" value="XM_067202787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GDH3"/>
    <dbReference type="SMR" id="A0A836GDH3"/>
    <dbReference type="GeneID" id="92356721"/>
    <dbReference type="KEGG" id="loi:92356721"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004483">
        <property type="term" value="F:methyltransferase cap1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016556">
        <property type="term" value="P:mRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12760:FF:000005">
        <property type="entry name" value="Methyltransferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050851">
        <property type="entry name" value="mRNA_Cap_2O-Ribose_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025816">
        <property type="entry name" value="RrmJ-type_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16121:SF0">
        <property type="entry name" value="CAP-SPECIFIC MRNA (NUCLEOSIDE-2'-O-)-METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16121">
        <property type="entry name" value="CAP-SPECIFIC MRNA (NUCLEOSIDE-2'-O-)-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51613">
        <property type="entry name" value="SAM_MT_RRMJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 11" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="4 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RrmJ-type SAM-dependent 2'-O-MTase" evidence="13">
        <location>
            <begin position="86"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG5465257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="400" mass="44884" checksum="77A26B37DD427539" modified="2021-09-29" version="1">MKKTVEDRSLEFLIRRDMGAELPPLASLSCENFTRHHWRDAFDDEQAALREEVWAVKSRLDTIPAGVYTATRNRLFPLAVSGEQRHFSNRAGHKLLQSMESTGVWMELLKLLRGKSLKRPRDFAFADLCGGPGAFSQALFQASRRQGWRHVHGYGMTLAGVSGLDWYGHLLKSPQFTCTYGLDGTGDIFQLSNIDCLASITKAAPMLLVVADGGFHVDLSIANYQETISSRIMYGQWLAALKLLRKGGCLVLKLFDTFSPLSRAVLYLSSFLYRRVHIAKPRHSRVVNSERYLVCVGFLGCPSEQWSRYLDSFYEQGFVDNEHVPELIPREWCLEDAVFMSDMRDVNSAVATNQMIALRMIIDAAPGVAEELQAKEADKKVAAEFDEGSESAPGQSEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GE10</accession>
    <name>A0A836GE10_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060881.1">
        <property type="nucleotide sequence ID" value="XM_067205329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GE10"/>
    <dbReference type="GeneID" id="92359263"/>
    <dbReference type="KEGG" id="loi:92359263"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5471764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="374" mass="39464" checksum="021402BF38AB5FBD" modified="2021-09-29" version="1">MFRPADDQMKRMAAYGMQRGVVHDMGAMLRLEEQQAFMMQMREMEMMQMQAMGCVPSHACDPWASPLEQLQPMEQEYPSQQQRSTGSCTSPYACENATATTPGSSAPPRSATKPESIGAATSTSPSTINARCGVGRSDASPQPGDPSAYAPNSLYRTMSSAADVKEPPAAQESMYNGSSMYAGNTSACAPPLMGGGLNENGASTAGYSMCEANNGGSMYEQPVPSSDAVVSGPTKSAPATDALAAGSSSKAATPLPLRKTSGTGVSPSLQRKPSVSALEKKGSLASMSRDDKTSISSHRSREIRRKSSELKRQSRSGTANHGPRSPSIRSSSAEKKRSSPADKNKQSSPSSIKDKSNHRSSSSSSAKDNDKKRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GEM9</accession>
    <name>A0A836GEM9_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061584.1">
        <property type="nucleotide sequence ID" value="XM_067205647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GEM9"/>
    <dbReference type="GeneID" id="92359581"/>
    <dbReference type="KEGG" id="loi:92359581"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="556"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="627"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="579"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="590"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="632"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5473581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="726" mass="76677" checksum="A7DB23E1D4061BEA" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GFH3</accession>
    <name>A0A836GFH3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histidine phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059422.1">
        <property type="nucleotide sequence ID" value="XM_067203731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GFH3"/>
    <dbReference type="GeneID" id="92357665"/>
    <dbReference type="KEGG" id="loi:92357665"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF33">
        <property type="entry name" value="PEPTIDASE S54 RHOMBOID DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032941011" description="Histidine phosphatase" evidence="1">
        <location>
            <begin position="25"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5466532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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                <person name="Bates M.D."/>
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                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Bates M.D."/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1007"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1037"/>
            <end position="1063"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5467685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1070" mass="115521" checksum="6E83B3F7B278864E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GLG7</accession>
    <name>A0A836GLG7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_00779</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059502.1">
        <property type="nucleotide sequence ID" value="XM_067202852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GLG7"/>
    <dbReference type="SMR" id="A0A836GLG7"/>
    <dbReference type="GeneID" id="92356786"/>
    <dbReference type="KEGG" id="loi:92356786"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032383013" description="GOLD domain-containing protein" evidence="3">
        <location>
            <begin position="25"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="4">
        <location>
            <begin position="260"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5467700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="350" mass="38278" checksum="F5DE2492DFB447B3" modified="2021-09-29" version="1">MRQAKMQCLALLASLVWLAAGVQAVLYLNLNSADYPAYAGKKVSMKEYAALPGGKAACVLLSLDNGLGGVVRFTYSSNVSSLHWRSDVVVSIHKPSASQPSVAILESIDAVTETNVYSAEELERRRSAAQVVRRGSERQGTANAGTEAVQQPQSTTVSVRPALNGIGPAAKFIDGNYAACFHLIRSKAAAQKMLPLQYEQVTIQLLEVVSTRRSTLTYIAGLNGAESSQNGDAAAGGTLAEVDREYAMIRSLLRASGTPDLRALLEQEEVVTSEEVKRQLEDFKSLQKQLFGVYDGFEHLEDRFLRMRVTAERTFSRIWACTMLTLLAMGGTMWLTFRHTKGIIIKKKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GNP8</accession>
    <name>A0A836GNP8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Alpha-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_04411</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062605.1">
        <property type="nucleotide sequence ID" value="XM_067206396.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836GNP8"/>
    <dbReference type="GeneID" id="92360330"/>
    <dbReference type="KEGG" id="loi:92360330"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031037">
        <property type="term" value="P:myosin II filament disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903013">
        <property type="term" value="P:response to differentiation-inducing factor 1"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16968">
        <property type="entry name" value="Alpha_kinase_MHCK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.200.10">
        <property type="entry name" value="MHCK/EF2 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004166">
        <property type="entry name" value="a-kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051852">
        <property type="entry name" value="Alpha-type_PK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45992:SF2">
        <property type="entry name" value="EUKARYOTIC ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45992">
        <property type="entry name" value="EUKARYOTIC ELONGATION FACTOR 2 KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02816">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00811">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51158">
        <property type="entry name" value="ALPHA_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Alpha-type protein kinase" evidence="7">
        <location>
            <begin position="1154"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="61"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="134"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="230"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="357"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="484"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="572"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="842"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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            <end position="1105"/>
        </location>
    </feature>
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        <location>
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            <end position="1465"/>
        </location>
    </feature>
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        <location>
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            <end position="1580"/>
        </location>
    </feature>
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        <location>
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            <end position="1638"/>
        </location>
    </feature>
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        <location>
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            <end position="1725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="141"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="516"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="529"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="582"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="596"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="608"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1076"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1094"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1410"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1453"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1619"/>
            <end position="1629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1714"/>
            <end position="1725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5477194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1725" mass="181164" checksum="2F4CBA58D54A855D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GPJ9</accession>
    <name>A0A836GPJ9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_03120</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">LSCM4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-13 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060689.1">
        <property type="nucleotide sequence ID" value="XM_067205137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GPJ9"/>
    <dbReference type="SMR" id="A0A836GPJ9"/>
    <dbReference type="GeneID" id="92359071"/>
    <dbReference type="KEGG" id="loi:92359071"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007019">
        <property type="term" value="P:microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="KISc_KIF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47971:SF16">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47971">
        <property type="entry name" value="KINESIN-RELATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4 6 7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="10">
        <location>
            <begin position="320"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="75"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="135"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="208"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="253"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="662"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="774"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="932"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="869"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="212"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="662"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="681"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="693"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="713"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="739"/>
            <end position="752"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="775"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="406"/>
            <end position="413"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00061030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5471572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="952" mass="102897" checksum="AF1AFE6A305C9F2E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GPY2</accession>
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        <submittedName>
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        </submittedName>
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        <name evidence="2" type="ORF">LSCM4_01749</name>
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        <name type="scientific">Leishmania orientalis</name>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="92357729"/>
    <dbReference type="KEGG" id="loi:92357729"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5479161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="96" mass="10796" checksum="031368B5DAD16CC5" modified="2021-09-29" version="1">MSHLSPIEVLWANLLEAAASASPSASLPRGHRYRRHARRRQRSSPRFCAYASKQRAGQFWCAVPCGPERASVKKREKKVTFSPFVSVVEFTVVPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GRH0</accession>
    <name>A0A836GRH0_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000007">
        <property type="protein sequence ID" value="KAG5486792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067208181.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="loi:92362115"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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            <end position="209"/>
        </location>
    </feature>
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        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5486792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="314" mass="34728" checksum="0834C058A906B305" modified="2021-09-29" version="1">MGIDALSLLVACATRAAVKSDETRTIERALDDLQEQMFGVEKPHEVATEILLKRILEIQALLTKDSESSKGTLITERLLLEAVLTLSELLLSAAAGQKLRTKTAKRVEDVILPILFLRTSITPSLLKAHALKAVWSRFECSGKDENEAREKLRRIFASWHRNHGWDFVRRSVECADLSKSTPPLRGAADPAKDALEKKPACCSPPAQPAPQRAVLRDIPWNAAARKVATSGIPSYLLTKRRRYDPTSQCDGLASARADEGAPNRLQPTAQLPSSADSDRTGFRMNPSILALESPVRRRRRDFTVDVPPSPDRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GTE7</accession>
    <name>A0A836GTE7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063500.1">
        <property type="nucleotide sequence ID" value="XM_067207727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GTE7"/>
    <dbReference type="GeneID" id="92361661"/>
    <dbReference type="KEGG" id="loi:92361661"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053125">
        <property type="entry name" value="RNA-bd_mRNA_stabilization_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37035:SF4">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37035">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="85" mass="9812" checksum="C970F188133359F2" modified="2021-09-29" version="1">MRLSAGKIYFWGAITIVFLTAWNRSSTAQLRTVVDGLKEERMREAERLRQYQHGGAPASMPASTMPKHFNPYYQQQEMENTSTDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GUR2</accession>
    <name>A0A836GUR2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Delta(14)-sterol reductase ERG24</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">C-14 sterol reductase ERG24</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Sterol C14-reductase ERG24</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">LSCM4_02917</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17813"/>
            <dbReference type="ChEBI" id="CHEBI:18364"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.70"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="14">
            <dbReference type="Rhea" id="RHEA:18563"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="15">Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 2/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060489.1">
        <property type="nucleotide sequence ID" value="XM_067204937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GUR2"/>
    <dbReference type="SMR" id="A0A836GUR2"/>
    <dbReference type="GeneID" id="92358871"/>
    <dbReference type="KEGG" id="loi:92358871"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050613">
        <property type="term" value="F:Delta14-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046165">
        <property type="term" value="P:alcohol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016129">
        <property type="term" value="P:phytosteroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902652">
        <property type="term" value="P:secondary alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000009">
        <property type="entry name" value="C-14 sterol reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018083">
        <property type="entry name" value="Sterol_reductase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF52">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE TM7SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01017">
        <property type="entry name" value="STEROL_REDUCT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="9" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="12" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00060638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00074394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00077841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00083315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAG5470223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="437" mass="48822" checksum="05C0C3F0119B75DB" modified="2021-09-29" version="1">MARSSSAASKAEGNPLQPRTVTYEWGGPLGGLFMILFLPALVVALNSLCGEEQCSLMQVMQLSALMKEVVQRAWPMVPTAIGIELVWLAAHAVFSILPIGKLVYGGQLRNGERLPYRMNAIHAFFISHLVLFVMHCCSILNVTVVADLYHPLMIGAIIISFAMSVVLYAASYRSGKVLTALGGNSGNALYDFWIGRELNPRTGPLDWKMMCELRPGLIGWSIINWAFVCKSAELGTMTPSIVLTALFESFYVLDGLLLEAGNLTMMDIVTDGFGFMLCFGDLAWVPFTYTLQTNYLVHHPARLSPLHLGLCASLSVAGYLIFRGANTEKNRFRSNPQDPRVQHLRVMKTSKGKSLIISGYWGICRHPNYVGDWLMALGWAAFSGTAELLPYFHPVYFGFLLLHRQLRDEQQMLEKYGKEDWGAFCSVVQYRLFPYIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GVP9</accession>
    <name>A0A836GVP9_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_00480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058659.1">
        <property type="nucleotide sequence ID" value="XM_067202558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GVP9"/>
    <dbReference type="SMR" id="A0A836GVP9"/>
    <dbReference type="GeneID" id="92356492"/>
    <dbReference type="KEGG" id="loi:92356492"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5465028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="160" mass="17470" checksum="7A7D2B2BB3D9E6B8" modified="2021-09-29" version="1">MMRSSFVRKGASAVAGGAAVAGSNDLKMASLHKLLTGEVQFRNGALLKECNIEHNFGANWKADMELYAKSLPADQKKILERQIARVTLTRYTTRELAEYCGEGPEHVDAVAREANIAQAKAYAQLNGTEKLEAYVKAESRNAGWSDAEAKKFMDAVKSAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GW56</accession>
    <name>A0A836GW56_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FCP1 homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_01325</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059071.1">
        <property type="nucleotide sequence ID" value="XM_067203380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GW56"/>
    <dbReference type="GeneID" id="92357314"/>
    <dbReference type="KEGG" id="loi:92357314"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000303">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit TIM50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
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            <begin position="69"/>
            <end position="222"/>
        </location>
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            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
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            <dbReference type="ARBA" id="ARBA00022771"/>
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            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50103"/>
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            <dbReference type="PROSITE" id="PS50969"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5466181.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="601" mass="66275" checksum="D237097C11C4BFCC" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1">LSCM4</strain>
        </source>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <dbReference type="EMBL" id="KAG5480324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="372" mass="40736" checksum="677DE97586FB639F" modified="2021-09-29" version="1">MEADSRLVAIEPCDVAELQAEFAGHSPRAAYTTICHRFRVTPLASAAVLFPDVAGAWDAVTTLDFSRTYVGSKGALPVIELCRRLPRLQSLVLSDNYLSNDTVWRLVQVALFHPCLERIDLSANEHISWCGAMCLVELVLRNPRVIYVGLRGSTVSPEILQSIEAQTRQNAVGRFRSGDLKRSPPAHPAAVYIRALKHLFSTHEQHGRVSASLLQSGFEELLRVSGRTGELRLLTDKYFSKLKARVPPGGLTCDAFLVLLLIDGSTYNEATVAELKHVFTMFNMDPSVPDPISDGYVLAGDMADIMARVYGSRPSDADVAALQRRLGVDTGATTLGWEEFLCIAYPHGPQVGDRLCGVACTPLANPIEVMHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GZ26</accession>
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        <recommendedName>
            <fullName evidence="7">Ion transport domain-containing protein</fullName>
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        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Trypanosomatida</taxon>
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            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
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    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG5474570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_067205739.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="92359673"/>
    <dbReference type="KEGG" id="loi:92359673"/>
    <dbReference type="Proteomes" id="UP000674143">
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24186:SF38">
        <property type="entry name" value="ANKYRIN REPEAT FAMILY PROTEIN"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR24186">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="516"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
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            <end position="569"/>
        </location>
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        </location>
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        <location>
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        </location>
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        <location>
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        <location>
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        <location>
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        </location>
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        <location>
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        </location>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="1521"/>
            <end position="1547"/>
        </location>
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        <location>
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        <location>
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            <end position="1661"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1732"/>
            <end position="1754"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5474570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2057" mass="232659" checksum="9BC9684980BD52A9" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GZD8</accession>
    <name>A0A836GZD8_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_07178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000015">
        <property type="protein sequence ID" value="KAG5482969.1"/>
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        <property type="project" value="TreeGrafter"/>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5482969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="797" mass="85598" checksum="7DA577AE69008C1F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H073</accession>
    <name>A0A836H073_9TRYP</name>
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        <recommendedName>
            <fullName evidence="5">SET domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="3" type="ORF">LSCM4_05620</name>
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    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000016">
        <property type="protein sequence ID" value="KAG5482364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067207556.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="92361490"/>
    <dbReference type="KEGG" id="loi:92361490"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
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    </dbReference>
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        <property type="entry name" value="SET_dom_sf"/>
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        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF137">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="329"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5482364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="801" mass="87472" checksum="42436B276CF10AE5" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H131</accession>
    <name>A0A836H131_9TRYP</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="1" type="ORF">LSCM4_04217</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062143.1">
        <property type="nucleotide sequence ID" value="XM_067206206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H131"/>
    <dbReference type="GeneID" id="92360140"/>
    <dbReference type="KEGG" id="loi:92360140"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5475635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="144" mass="16053" checksum="7B9681A41FEAD8B0" modified="2021-09-29" version="1">MSRVLTVLLTYDDPECGGAADALVEHLERDAAAVEGHCQLSVKPIQVLQSGSHRDALYGSLQDLFQMKPQDIFVITFLKGSQPEEYRKVTELCNSVRPTAVQCQVLTHLANYNDVGLIIRNLVRLVLDEMTKEEVNRSNAEPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H173</accession>
    <name>A0A836H173_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine aminopeptidase S33 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5468956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059933.1">
        <property type="nucleotide sequence ID" value="XM_067204381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H173"/>
    <dbReference type="GeneID" id="92358315"/>
    <dbReference type="KEGG" id="loi:92358315"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF81">
        <property type="entry name" value="PROTEIN ABHD13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="1">
        <location>
            <begin position="69"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5468956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="406" mass="44963" checksum="D20DBE0305AC1110" modified="2021-09-29" version="1">MQSFVNSIVFLPPRNPNSLQRVQLLQHKRYMSFTKKKSGEIISYYHFDSKGDLVTRDSLERVVRSSMVALIHHGNAEDLGGAFDHAKSIACRCGVAVVVYDYCGYGLSGFPDAATPVEVTEKSVYSDADHMYAHLLSLGYPAHRIVIVGRSVGGGPACYLAEKHHKEVSGLVLISTFTSCLRVVSSCCLPYLCCCFDLFPNYRRVESVMECPVLVMHGTQDHVVPYRCSRELLQDIEAHRTHELQCLLKKRERSRAKRARGSGTPIATSAALMNPMKESKITRVPDELVTTTHPPPLDGEATSVFDLYRRAYDGLPEAVRRMAEERLDVTAANVSIGAFHSWFVGCGHNDIEAREGKTFSDALMYFLRFASAFSVEREALLSAKLLTGLTTASADSANRADGEGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H2Y3</accession>
    <name>A0A836H2Y3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transmembrane protein 234</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_04765</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM234 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000023">
        <property type="protein sequence ID" value="KAG5478532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063193.1">
        <property type="nucleotide sequence ID" value="XM_067206746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H2Y3"/>
    <dbReference type="GeneID" id="92360680"/>
    <dbReference type="KEGG" id="loi:92360680"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
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        <property type="entry name" value="TMEM234"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28668">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28668:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10639">
        <property type="entry name" value="TMEM234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032402760" description="Transmembrane protein 234" evidence="7">
        <location>
            <begin position="18"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5478532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="121" mass="13069" checksum="4608D7CEB850613E" modified="2021-09-29" version="1">MILLMLLAALLWGVTNPLLKHYSRGMANCGSAKDDALFLMRRPKYLVTQVVNLSGSVVFFFSLREVDVSVGSIVVNSLAFVITVLMSVFVLREGMLCARTAVGCALVMVGTALCTYSSSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H478</accession>
    <name>A0A836H478_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_02819</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060391.1">
        <property type="nucleotide sequence ID" value="XM_067204839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H478"/>
    <dbReference type="GeneID" id="92358773"/>
    <dbReference type="KEGG" id="loi:92358773"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5470125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="161" mass="18821" checksum="7E281BCE64A95F88" modified="2021-09-29" version="1">MKWLGRLMRRKKRTPLPPKPYVDTASTGQHMCDPRLYDSHDLSHIDPEKPHWQDVRFESRERVPFFDIFGYNRDWSWTLFKMSSLFFVMILYWEVRSLAYMKDDPIRISSTTTVSPVPEYARDEKATEEELREAGFAYVGVAKLDNLGIPAPSSSEAGRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H496</accession>
    <name>A0A836H496_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA/pantothenate metabolism flavoprotein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_04548</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPC synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062741.1">
        <property type="nucleotide sequence ID" value="XM_067206532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H496"/>
    <dbReference type="SMR" id="A0A836H496"/>
    <dbReference type="GeneID" id="92360466"/>
    <dbReference type="KEGG" id="loi:92360466"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="CoaB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CoaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007085">
        <property type="entry name" value="DNA/pantothenate-metab_flavo_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12290">
        <property type="entry name" value="CORNICHON-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04127">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102645">
        <property type="entry name" value="CoaB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/pantothenate metabolism flavoprotein C-terminal" evidence="2">
        <location>
            <begin position="48"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="DNA/pantothenate metabolism flavoprotein C-terminal" evidence="2">
        <location>
            <begin position="176"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5477330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="334" mass="36339" checksum="8664DF17B4D63ADB" modified="2021-09-29" version="1">MQKDVDAFYAENMPAETQARLSAHKDTLLAFLEGVARSHPDCPGIAYITSGGTTVPLEVNAVRFITNFSSGGRGASLVETLAERGWACVLLHHRTAHMPFRRALDRLSTEQLFDAVSPPAASSGAVMSPASASGAESTLAAARRAELQRAAVLYHRTKGLVHYIAFDTVVEYVFLLEVVSRALCSAAVPQLLQQRPCLFFAAAAVSDYYVPLPKMSKEKISGGDGLTLHLSNVPKVLLLVREEWLRRTTPCAKQPFVVTFKLETSEAAMKRKAISNLHKYNCDAVVANMLQSYKDWVLIYTKSGDDSTPVLVQSEAAKTIEAALCDALIPLCQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H4Z3</accession>
    <name>A0A836H4Z3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfatase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_07657</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000012">
        <property type="protein sequence ID" value="KAG5484884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064996.1">
        <property type="nucleotide sequence ID" value="XM_067209536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H4Z3"/>
    <dbReference type="GeneID" id="92363470"/>
    <dbReference type="KEGG" id="loi:92363470"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="3">
        <location>
            <begin position="364"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5484884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="517" mass="55079" checksum="862421D2A4A10FE0" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H5M0</accession>
    <name>A0A836H5M0_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_04100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG5475518.1"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5475518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="328" mass="34817" checksum="BF48339DC5D4A505" modified="2021-09-29" version="1">MWRLYIPSSLSEAPTVGGVSILVGQRSCVSFSANEASCTVCVLAGYVPCDDPSVAEEQIECLEHVLPFGIEVLGFAGDTAALTSLTAQLPDLKRRELVEAVMHNGKGHRQPVCRMLGAPLKKVETVSSEIAFVEARCALHSYDSSAPLLLSCSNAPPQVVDGESDAPLMERAPSSSSKMELVQTGAVSSTLRIHVVMAPSLTSPRGLYETLFRQLKAASTAGTTRLIELNAHNAHFSYCCRLECGADALANTGTVTEDEWAKVLEMMEDATGQGVLRVDVRDARLLLESCQESAASAAKAAKKSLAQLRPYLLLGVIVALMAAVALVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H7N1</accession>
    <name>A0A836H7N1_9TRYP</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">LSCM4_08374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
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        <lineage>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000001">
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    </dbReference>
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        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <end position="212"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5488296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="455" mass="47637" checksum="CC121FB38973741A" modified="2021-09-29" version="1">MSAAVKTAAPAAVRGSRRWDPSCYYQSLSAVVDGDVRFGEGCVVLSHARIHVSPGYRLLVGPFCLFEDFSELICDSAAAVAGHRRAGEGQASSAALADADSASPSWKAAVTLRIGSHNHLHSYARVRCTVATSTQSPCSPSSPTWQLMGRGNVLHAFADVLMTLPQASLRLAKPPAAQAQSFFGNYNVVTTHSRVSLPQAAAAAPSANAGEQGARRPRPDEHRGTQLLDAPQRSVISNELPPSAAALSVETLPKPVSVEERLFHNEDDVDVLGGAHAQTQAPPAYSAPHPRAGDCIHSEAASLSASAGPSIEASSGFQHLVFFSETHNAVAEASAALAASAFSVPRFGARSVAELPVVINRIADEAKAGPQTAAETVGTASVVAAPPPFASASPPSGSSAAASPTAAMLERCVSDVHPHLRLHEEKRIIREVERVCRYYIAHFLDDRGLKLAEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H943</accession>
    <name>A0A836H943_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sulfhydryl oxidase</fullName>
            <ecNumber evidence="8">1.8.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_01965</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Euglenozoa</taxon>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <reaction evidence="8">
            <text>2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2</text>
            <dbReference type="Rhea" id="RHEA:17357"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16520"/>
            <dbReference type="ChEBI" id="CHEBI:17412"/>
            <dbReference type="EC" id="1.8.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="8"/>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067204004.1"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A836H943"/>
    <dbReference type="GeneID" id="92357938"/>
    <dbReference type="KEGG" id="loi:92357938"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:Golgi membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="ERV/ALR sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
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        <property type="entry name" value="QSOX_pErv"/>
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    <dbReference type="InterPro" id="IPR039798">
        <property type="entry name" value="Sulfhydryl_oxidase"/>
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        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22897">
        <property type="entry name" value="QUIESCIN Q6-RELATED SULFHYDRYL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22897:SF8">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04777">
        <property type="entry name" value="Evr1_Alr"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 8" id="KW-0274">FAD</keyword>
    <keyword evidence="2 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
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    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
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        <location>
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        </location>
    </feature>
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            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="10">
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        </location>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5472645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="555" mass="62210" checksum="4025F00139485A4A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H9I9</accession>
    <name>A0A836H9I9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ankyrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061534.1">
        <property type="nucleotide sequence ID" value="XM_067205597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H9I9"/>
    <dbReference type="GeneID" id="92359531"/>
    <dbReference type="KEGG" id="loi:92359531"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000678">
        <property type="entry name" value="Ankyrin repeats (3 copies), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5473531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="714" mass="75896" checksum="A1691A7805A43A3F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HDR5</accession>
    <name>A0A836HDR5_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_07843</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000013">
        <property type="protein sequence ID" value="KAG5484277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064770.1">
        <property type="nucleotide sequence ID" value="XM_067209720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HDR5"/>
    <dbReference type="SMR" id="A0A836HDR5"/>
    <dbReference type="GeneID" id="92363654"/>
    <dbReference type="KEGG" id="loi:92363654"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5484277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="201" mass="22965" checksum="7D1BB2EC8C40D767" modified="2021-09-29" version="1">MVESRIKQLLRATTEAPEDQRTQIQNLYETIEQLSKRCRHLENESERRRIIIDDLRAHVTRLEELFGKSQCEMAYAQQQLEFVVMSLESQHGIVADHTEQLRLFAGVSTNRGYAMTQRNAQRSLLLLIGNWLYTPVVHFAKGVYTLFSPIITTAQSLSLLNSDVLHRNSSDRLRWGAARKGDLLGMLQRGALDPDSAASRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HE45</accession>
    <name>A0A836HE45_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA N(3)-methylcytidine methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_05709</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">S-adenosyl-L-methionine-dependent methyltransferase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the methyltransferase superfamily. METL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063414.1">
        <property type="nucleotide sequence ID" value="XM_067207641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HE45"/>
    <dbReference type="SMR" id="A0A836HE45"/>
    <dbReference type="GeneID" id="92361575"/>
    <dbReference type="KEGG" id="loi:92361575"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026113">
        <property type="entry name" value="METTL2/6/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809:SF14">
        <property type="entry name" value="TRNA N(3)-METHYLCYTIDINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037755">
        <property type="entry name" value="Mettl2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 12" evidence="5">
        <location>
            <begin position="114"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR037755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5479703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="346" mass="38573" checksum="80EF5288F962152F" modified="2021-09-29" version="1">MESDSCPHIPITRSGGTFKFSKDVKLHANDFEWDAKVAELTANERILVDDYMRRCVTELSRVGSSTSLEEVPAQPWETHFSASKHHFPLKNYIVHAFPLLRSVLDRRDSPAWILECGCGTGSTLLPIMRECSSSNIHFVGFDISPSALAHFKSHEIAQSYLQRNQLTVFPLAIGTPTALADEDNIEPAVKRQRTNGNATLVVDALSAANESLQNQRFDAILVVFVLSALPTVEKMVAALEQLKRVLKQDGILFFRDYALPDHNFFRFASKTDRGLDSIAFSKGDCTTQVFFHKEFATELFASVGLVEVGDAASKLTYHCNRLVNRKNGKKMDKIFINGAFKLASIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HG86</accession>
    <name>A0A836HG86_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_04499</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062692.1">
        <property type="nucleotide sequence ID" value="XM_067206483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HG86"/>
    <dbReference type="GeneID" id="92360417"/>
    <dbReference type="KEGG" id="loi:92360417"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5477281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="86" mass="9676" checksum="FF5529D7F0A2CBF0" modified="2021-09-29" version="1">MYAAGATVHRTRRPHPPPDNSKHYTEVPPRTVKQHNAIYCARKRLSTDFGVDDMQPMEKIGMLIAVLLFVLLAVGGPIYIIRYALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HHH3</accession>
    <name>A0A836HHH3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Flagellar attachment zone protein 1 conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_07079</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000018">
        <property type="protein sequence ID" value="KAG5481368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064047.1">
        <property type="nucleotide sequence ID" value="XM_067208984.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92362918"/>
    <dbReference type="KEGG" id="loi:92362918"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056614">
        <property type="entry name" value="FAZ1_cons"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23398">
        <property type="entry name" value="FAZ1_cons"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flagellar attachment zone protein 1 conserved" evidence="2">
        <location>
            <begin position="596"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="518"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="702"/>
            <end position="751"/>
        </location>
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            <end position="354"/>
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    </feature>
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        <source>
            <dbReference type="Pfam" id="PF23398"/>
        </source>
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        </source>
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    <sequence length="1680" mass="175166" checksum="8B65694B8D56D693" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HKF3</accession>
    <name>A0A836HKF3_9TRYP</name>
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        <recommendedName>
            <fullName evidence="4">Tyrosine phospatase-like protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">LSCM4_07543</name>
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    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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            <dbReference type="EMBL" id="KAG5487862.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HLQ4</accession>
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    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">LSCM4_06077</name>
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    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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        <location>
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            <end position="62"/>
        </location>
    </feature>
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        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5480311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="208" mass="24394" checksum="9DC7CAA2A13FA9E0" modified="2021-09-29" version="1">MTLRQRWNSSARCDTEGQCTDPLQRLLARNLQRRGVAAVLKKRRAPPHARPRSMSPDAREARRRHELARSAQEMIDLERYERRQLATLARKRFHAIASLFFGTVAENLIACELSGRRRLFRQWQEGHCYLAASMGSELRRLTSMTPQGFKAVCRLIHSEAVKRRRIQVTEEEDRDLYARFMYVEQLKMLGKESNECRRRAVWPPCRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836HN39_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_07980</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000013">
        <property type="protein sequence ID" value="KAG5484413.1"/>
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    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
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    </dbReference>
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        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HECTD3"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR46654">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HECTD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46654:SF2">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0833">Ubl conjugation pathway</keyword>
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        <location>
            <begin position="26"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="4">
        <location>
            <begin position="4267"/>
            <end position="4495"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="4">
        <location>
            <begin position="4546"/>
            <end position="4787"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="5">
        <location>
            <begin position="5092"/>
            <end position="5598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1235"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1461"/>
            <end position="1481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1690"/>
            <end position="1726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2103"/>
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        </location>
    </feature>
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        <location>
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        <location>
            <begin position="5459"/>
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        <location>
            <begin position="1240"/>
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            <begin position="1259"/>
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        <location>
            <begin position="1461"/>
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        <source>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="PROSITE" id="PS50188"/>
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        <source>
            <dbReference type="PROSITE" id="PS50237"/>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
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    <sequence length="5629" mass="593882" checksum="2B27AB7C6074F025" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HP76</accession>
    <name>A0A836HP76_9TRYP</name>
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        </recommendedName>
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        <name evidence="8" type="ORF">LSCM4_07478</name>
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        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Trypanosomatida</taxon>
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    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
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    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000004">
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            <dbReference type="Proteomes" id="UP000674143"/>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836HQC5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Srp40 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_06554</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
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            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000010">
        <property type="protein sequence ID" value="KAG5485598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="185"/>
            <end position="252"/>
        </location>
    </feature>
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        <location>
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        </location>
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            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5485598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="258" mass="28357" checksum="79104B6B50FB966E" modified="2021-09-29" version="1">MSRAIDYLVAEYLAEEHPKVARALRKDAPSTAPPSRFPFGKKSLQEVVMAYRAQKALRAAVGNGTSSDGEQGAQLPLQKAAMALSPKPMPKPAAKKAPIADSDSDDEPVRKPAAKRASPKLIPKSAAVDSDSSEDVEPVRTNSVVSKARAPRAVDEPTRKAARTEPTRAARGMPHHLNEDGTFRRFQRIDPTKVMFQADALRDNRPGEEHLVLRQNQEMMRTKGKGFNKLKQKNKGKFYGAGVDLSVRAYQFPDSDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HUA6</accession>
    <name>A0A836HUA6_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_07253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000015">
        <property type="protein sequence ID" value="KAG5483040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064536.1">
        <property type="nucleotide sequence ID" value="XM_067209153.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92363087"/>
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                <person name="Bates M.D."/>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="129"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="78"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5487783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="157" mass="17527" checksum="A987369FAE634B3C" modified="2021-09-29" version="1">MRRCLAAASGWLTARRRTTTVSGAVGYLSHRPPLTEADARKTASTTPTTAAVAPTSEDYRALLLDLLLYRRETLAPVVEALRRERDEVEKKMQHLDTHVRELSSIRDELRQLAEEMRSAEQARLHSLVMERSKSSAAENAKAAEAAAESRDDEEIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KAC3</accession>
    <name>A0A836KAC3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pru domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_01351</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059096.1">
        <property type="nucleotide sequence ID" value="XM_067203405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KAC3"/>
    <dbReference type="SMR" id="A0A836KAC3"/>
    <dbReference type="GeneID" id="92357339"/>
    <dbReference type="KEGG" id="loi:92357339"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
        <property type="term" value="F:endopeptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.70:FF:000007">
        <property type="entry name" value="Proteasome complex subunit Rpn13 ubiquitin receptor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2020.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.70">
        <property type="entry name" value="Proteasomal ubiquitin receptor Rpn13/ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006773">
        <property type="entry name" value="Rpn13/ADRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044868">
        <property type="entry name" value="Rpn13/ADRM1_Pru"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038633">
        <property type="entry name" value="Rpn13/ADRM1_Pru_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032368">
        <property type="entry name" value="RPN13_DEUBAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038108">
        <property type="entry name" value="RPN13_DEUBAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225">
        <property type="entry name" value="ADHESION REGULATING MOLECULE 1 110 KDA CELL MEMBRANE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225:SF0">
        <property type="entry name" value="PROTEASOMAL UBIQUITIN RECEPTOR ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04683">
        <property type="entry name" value="Rpn13_ADRM1_Pru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16550">
        <property type="entry name" value="RPN13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51917">
        <property type="entry name" value="PRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pru" evidence="6">
        <location>
            <begin position="7"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5466206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="247" mass="26659" checksum="9B8F79A7BC0389B2" modified="2021-09-29" version="1">MIPPPVFSKTPELQFRAGKMKYAGGIVTADKRKGYLSFFSTGASSVEMIWASESEKSAPTVLPRGKTTVSFVPQCKTGRVLLLEVNEKDEKAQYFFWLQDKSEQKDSAYLTSLESMLAERTASSRSKATVNLEDFKKILASVSKSKKDVKLTDVLSSSIVTEELSSDPAYYSSKLAEHLPRGGGESDDILSQVKNPQVSQAAAILGVALQDPATYKQLCASFGVPETDANGGVLAFLNGIIAAAKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KAE1</accession>
    <name>A0A836KAE1_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_00348</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058533.1">
        <property type="nucleotide sequence ID" value="XM_067202432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KAE1"/>
    <dbReference type="GeneID" id="92356366"/>
    <dbReference type="KEGG" id="loi:92356366"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5464902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="305" mass="34271" checksum="70710D7F90CFEDAF" modified="2021-09-29" version="1">MDSLYFIGKAQFHQLATHISLYHEDMSTGYRHLSTDALMAAGLQPHKFTYWNVPMMSGYLGKAVPLDIHGGYVLIDEEKAMPMATSYGMLRYALLASAVRAKEGGRWRYDFMTMNSTLAIGTAAGCGFLSFGRKRIGWMRHHPVGCVMMSFVVCLTTTVIARQGIKGLGIGIVQAQNSHKKALSCLRCVDCLEDVNTYTLNQIEELKTQQIPQQVGMPPPPEEYVRRFKKSVEMQCKLLKVDMDEVRLIRKLAGGSLCDVHQHLRDDPKCYKEPHGLVLLASDRARAAERPPLVTEPDDRRPARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KAJ7</accession>
    <name>A0A836KAJ7_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_00549</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058728.1">
        <property type="nucleotide sequence ID" value="XM_067202627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KAJ7"/>
    <dbReference type="SMR" id="A0A836KAJ7"/>
    <dbReference type="GeneID" id="92356561"/>
    <dbReference type="KEGG" id="loi:92356561"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5465097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="278" mass="30214" checksum="5E940A8693F1FED6" modified="2021-09-29" version="1">MPTPPSYRELANVVNDYLTKGSDVHGWHLEAKEDGAPQRLSGYPFASPTGVGVDLCCKFPEFNTTLTSKVSAVFQSWREYLPTMIYQTRGDSVSAKIEVDTAAASVMVTAEHPVFNVSCKTSPLDGFVTDANMTTRVSEQLYAGASLQYDPKRSGVRDFTTVMVRYACPNIGNGDLLGKYSLQSGLSLHLRIPIHAYMDAAVAAERRRFIAGVQARSPCGARLLLNTNVTDGTCTMTAIRNMNDIWRVTATVTAPFASGGRDAAPRFGLKLTNMNALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KCW7</accession>
    <name>A0A836KCW7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Acetyl-CoA C-acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_03261</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">LSCM4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060826.1">
        <property type="nucleotide sequence ID" value="XM_067205274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KCW7"/>
    <dbReference type="SMR" id="A0A836KCW7"/>
    <dbReference type="GeneID" id="92359208"/>
    <dbReference type="KEGG" id="loi:92359208"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050521">
        <property type="entry name" value="3-ketoacyl-CoA_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42689">
        <property type="entry name" value="ACETYL-COA ACYLTRANSFERASE FADA2 (3-KETOACYL-COA THIOLASE) (BETA-KETOTHIOLASE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42689:SF1">
        <property type="entry name" value="ACETYL-COA ACYLTRANSFERASE FADA2 (3-KETOACYL-COA THIOLASE) (BETA-KETOTHIOLASE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="5">
        <location>
            <begin position="6"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="6">
        <location>
            <begin position="191"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5471709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="35516" checksum="CECB694CB92730A7" modified="2021-09-29" version="1">MLVEGEHADVVIAGGSDSVSNAELPLPRSVTHGLMMAQRKGIMGFFKEAGYNPSRWLPSGVALTERSTGKTMGWHGDVIGELNSISREDQEALAVASHANAARAEKAGYFSDEIVPVMVDATKNIEVKCDDVLQRDTEKMKAKMPSLKPVFRKDKGTITAATSSALTDGGSAMLVMSEEKAKKLGYPTDVSVKSWYFCGIDPYPQLLLAPVLGWGPALRKAGLAPKDIDLYEIHEAFAAQVLATIKRLRSQEFFDRYAGGGKPLLTEDIDRSRLNVNGGSLALGHPFAATGGRIVTSLANELRRSGKRHGLVSICAAGGLGGVAVLEHTPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KD16</accession>
    <name>A0A836KD16_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_01018</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059734.1">
        <property type="nucleotide sequence ID" value="XM_067203084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KD16"/>
    <dbReference type="SMR" id="A0A836KD16"/>
    <dbReference type="GeneID" id="92357018"/>
    <dbReference type="KEGG" id="loi:92357018"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033562">
        <property type="entry name" value="PLPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12406">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2 IPLA2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12406:SF42">
        <property type="entry name" value="PNPLA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="5">
        <location>
            <begin position="40"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="79"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="2">
        <location>
            <begin position="207"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5467932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="432" mass="48735" checksum="329B0C0252B27031" modified="2021-09-29" version="1">MSAFNNSASDSVASSSFDDETQLGQPQQREDKEQKWDITVSFSFGGWFQMYFIGVAYALIDSGVLQRWYTEGKRVRFTGVSSGALAATCLASGQYDILSIKQFALAAAEDCRSSVFHWFHVRKYLTVAIENFGAHLSAVDTDRRMREVLSSGSLEVGVTVLPSFRSRLISSFSSYAAIRETLIASCCLVPLVGLPVKMESTGEWCADGGFSNFTPRMEEENTISVSAMYFQDASVRPRVFVPSWWALRPPSTEKYNNLFWMGYNDMIDYLVSAGHLSMRNGNHLLMQEVDFRVHDSYLDVAFTFFMELMMLIYIRPVVIVLVYVELAISMAWWAAKGILTWDSTSLRNYYDGFRSSVSPRTLGRFIFGSKKPSNEERLSRQSRVFRVFEPVALGGNRKTGRECWSPKDAVLLGRVPTFSPNARLNAEGIQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KD66</accession>
    <name>A0A836KD66_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FPL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_01656</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059395.1">
        <property type="nucleotide sequence ID" value="XM_067203704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KD66"/>
    <dbReference type="SMR" id="A0A836KD66"/>
    <dbReference type="GeneID" id="92357638"/>
    <dbReference type="KEGG" id="loi:92357638"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901096">
        <property type="term" value="P:regulation of autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039272">
        <property type="entry name" value="CLEC16A/TT9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019155">
        <property type="entry name" value="CLEC16A/TT9_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21481">
        <property type="entry name" value="PROTEIN CLEC16A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21481:SF0">
        <property type="entry name" value="PROTEIN CLEC16A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09758">
        <property type="entry name" value="FPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FPL" evidence="2">
        <location>
            <begin position="54"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5466505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="925" mass="102474" checksum="271120AA3C176424" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KDW6</accession>
    <name>A0A836KDW6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_02966</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060537.1">
        <property type="nucleotide sequence ID" value="XM_067204985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KDW6"/>
    <dbReference type="GeneID" id="92358919"/>
    <dbReference type="KEGG" id="loi:92358919"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12416">
        <property type="entry name" value="RRM4_RBM28_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001047">
        <property type="entry name" value="Putative RNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051945">
        <property type="entry name" value="RRM_MRD1_RNA_proc_ribogen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN 14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039:SF5">
        <property type="entry name" value="RNA-BINDING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="111"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="308"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="424"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="85"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5470271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="447" mass="51061" checksum="77F792A520888D5A" modified="2021-09-29" version="1">MAKGTVKRRATPSSLRKKKAQQRIRKQIRTKLQKKKPNWKTALAKVYTGGANTLKDKKGSRKRTRDGLDDSDDGENTFNFKRDGEEEDGEVQSDVDEEKEERMNQRDPLETQLFLKNLPLDTSEEELMAYFRNHFSAVKRVLLVRNRASKTLSGTGFVHCGSAELATKIFEYAQQNAREVSATGREEMKAQTEGLSHHQAKRLMHKMRTDSFVVRDPFLTMRDTKFTVLRVLSRSDTQEAVSAQQKKKKRTKVAADDPRNLYLLQEGLVLPDSAAAKGLHPRYLQMIEDDYAARKQQLTNSNYFVSKTRLSVRNLPRTMSENDMRRLFAEQARAYLKKHPEDAEKGKWGKYGPIRNVKLLKDTAGVSRGYGFIEFVNHNVALHTLRMLNNNPTVFGDQRRLMVSFAIENTSALQRLQRMKELKRARLARGPSDGRGSAAPSKARKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KEU5</accession>
    <name>A0A836KEU5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sulfite exporter TauE/SafE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_02707</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060283.1">
        <property type="nucleotide sequence ID" value="XM_067204731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KEU5"/>
    <dbReference type="SMR" id="A0A836KEU5"/>
    <dbReference type="GeneID" id="92358665"/>
    <dbReference type="KEGG" id="loi:92358665"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031464">
        <property type="term" value="C:Cul4A-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14255">
        <property type="entry name" value="CEREBLON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14255:SF3">
        <property type="entry name" value="SULFITE EXPORTER TAUE_SAFE FAMILY PROTEIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032833037" description="Sulfite exporter TauE/SafE" evidence="7">
        <location>
            <begin position="29"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="463"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="235"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="235"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5470017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="507" mass="54706" checksum="3340B56ED7BCC66E" modified="2021-09-29" version="1">MRRDRGLKMCTTIGVALIATLWLSKVTAATTSCGFSTQRVQCGDLACDKVANICIACRSDSDCYPGAMRCDVASGKCKLRSFISLFGVRVVLAMLGAFSICSIAVIAGVGGGGILMPMFSWLMEISMQSAVGVSQSTVCGQCTLNMYLVVQQKHPDRNWDRPLINYQYLSLLLPLGLMGTLIGGILSRFCPDILRLILLFVLLSVVLYRTVKKMKTQYKEDTNAQQAIVQADDANTPSHRQNYGSNGVSESRGPAKTAGGVKSESREDTEALPASVQSPLTVERPPQPQYPKQEIAMNVACLLVVLLFGILRVYSVCGGFMYWLSSLVPLTFLGVVFYFNREKLRQLEESDPEQVTFAWTRQTTLVYPMVAVVAGAAAAVFGIGGGLVLGFVLNEVGIVPQEASVTGGMATFFIAVSSVLELIITSRLENDFGIAFSIAGFCSSILGYFFMRYIKEHGLNYLIIGSLAFIVGGSLITLGSYGIYNTVISVRSGGSVMAFGRLCSAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KFV4</accession>
    <name>A0A836KFV4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Small nuclear ribonucleoprotein Sm D2</fullName>
            <shortName evidence="9">Sm-D2</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">snRNP core protein D2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_02648</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the snRNP core protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060227.1">
        <property type="nucleotide sequence ID" value="XM_067204675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KFV4"/>
    <dbReference type="SMR" id="A0A836KFV4"/>
    <dbReference type="GeneID" id="92358609"/>
    <dbReference type="KEGG" id="loi:92358609"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030532">
        <property type="term" value="C:small nuclear ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01720">
        <property type="entry name" value="Sm_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000075">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027248">
        <property type="entry name" value="Sm_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12777">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="29"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5469250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="103" mass="11753" checksum="56E626AA2396E4EC" modified="2021-09-29" version="1">MDSEQPKKVARTETKTKELLRTTVADGPFSLLDTAMKEKKRVFIQCRNSKALLAHVIAFDKHFNLVLKGVQEITESHGSEQKQRTIENLFLRGESVIFIVKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KGG6</accession>
    <name>A0A836KGG6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Scaffold protein Nfu/NifU N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_00088</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NifU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058279.1">
        <property type="nucleotide sequence ID" value="XM_067202178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KGG6"/>
    <dbReference type="SMR" id="A0A836KGG6"/>
    <dbReference type="GeneID" id="92356112"/>
    <dbReference type="KEGG" id="loi:92356112"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.70">
        <property type="entry name" value="Scaffold protein Nfu/NifU, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014824">
        <property type="entry name" value="Nfu/NifU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036498">
        <property type="entry name" value="Nfu/NifU_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035433">
        <property type="entry name" value="NFU1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001075">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178">
        <property type="entry name" value="IRON-SULFUR CLUSTER SCAFFOLD PROTEIN NFU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178:SF49">
        <property type="entry name" value="PROTEIN 5, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08712">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01106">
        <property type="entry name" value="NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036773">
        <property type="entry name" value="HIRIP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00932">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110836">
        <property type="entry name" value="Hypothetical protein SAV1430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Scaffold protein Nfu/NifU N-terminal" evidence="2">
        <location>
            <begin position="13"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5464648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="260" mass="29789" checksum="6C228E6C345B889E" modified="2021-09-29" version="1">MLRRTLCRCMMHLHAQPTPNPLCRSFAIPADNFESFVPEGQTCEVAHRGLAWIHPLSQGLFEQYPQEVMSVFIAPRQVSISVYTNVDWSKIEWSVSSFLGHYLVFNNACISPAKEYTFIEDDLELKDGDSEVLQCIKELLREQVRPMVQRDGGDVKLLNFNERTGIVSLAMLGACRTCPSSQMTLKDGIERVMKHFLPEVTEVIEAKDHQFYEDYGLLFDSEKALYKEAARLDRERQARIRHKLTPTVLSYDALNEPDGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KGR9</accession>
    <name>A0A836KGR9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_02874</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060446.1">
        <property type="nucleotide sequence ID" value="XM_067204894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KGR9"/>
    <dbReference type="SMR" id="A0A836KGR9"/>
    <dbReference type="GeneID" id="92358828"/>
    <dbReference type="KEGG" id="loi:92358828"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000037">
        <property type="entry name" value="DnaJ heat shock protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000106">
        <property type="entry name" value="Putative heat shock protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051339">
        <property type="entry name" value="DnaJ_subfamily_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078:SF519">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="3"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5470180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="323" mass="35128" checksum="3AC1FA171A3AB81D" modified="2021-09-29" version="1">MIDYYQFLGLNRQSGDDDVAKAYRRYALAYNPQCHPDVTDQEALQRNFMTAAQAYTVLSDPKKRAIYDIYGEEGVRHGGTGQQGVPGGIDLDCIDPNAVFTRFFGVDNPFQVIGNIDGVKGNQHDFFSAISGMPPEPPKCPVMEVLLPVTLEDVFYGATRRATWNATHVDALEPDAAATTTAESYEVRVEKGAKTGDHFTVEGLGNTQPGCARGDVVVVVSVVEHARFRREGDDLVTKADISLRDALCGTTVTVCTMEGRELSILIDEIVDPTYRTRIAGEGLPSRGGGDAARGDLVIEFATKFPSFLTAEQKAEIGRILDAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KGX0</accession>
    <name>A0A836KGX0_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_04236</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062162.1">
        <property type="nucleotide sequence ID" value="XM_067206225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KGX0"/>
    <dbReference type="GeneID" id="92360159"/>
    <dbReference type="KEGG" id="loi:92360159"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5475654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="218" mass="23132" checksum="D848F3BAB9765961" modified="2021-09-29" version="1">MAASAFSPAVHLHNFRLLTVGNDTANTAPSSAPLTAPLSFSVTFCFYHCDEADLATTIAALGVAVDFVADVASEKKTLALLPLTPLSGPRAQADSITSNGAFLVAASPPDSLGSSSDWAVSAPRDGAVGAASSMMYRLTVHLNDFRALEGVQLKHLLQVSMVRVRLVRLGASDDVTGRSSSSSRTEERSIAAWNVVWQVRRNPQNEKELIRTVLDPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KHY4</accession>
    <name>A0A836KHY4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_03535</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061470.1">
        <property type="nucleotide sequence ID" value="XM_067205533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KHY4"/>
    <dbReference type="SMR" id="A0A836KHY4"/>
    <dbReference type="GeneID" id="92359467"/>
    <dbReference type="KEGG" id="loi:92359467"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000007">
        <property type="entry name" value="Sulfite oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359:SF146">
        <property type="entry name" value="B5, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="6">
        <location>
            <begin position="15"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5473467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="173" mass="18760" checksum="5F9340CDC231B304" modified="2021-09-29" version="1">MLTHLLQLAGLAQKWPTITREEVAKHNTRESLWIIVGNSVLDITPLLGQHPGGDGALLKRGGGVKDCAKDLMFHGRATRREAQKYKIGELPPRDVQKATPGPSATLPQAVPPLQPSPKVRAKVCVPTNLRERHLYCSDSEQWDDGAKNNPLSSSDTDIIAALGVNEVQPAPVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KJ70</accession>
    <name>A0A836KJ70_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Flagellar attachment zone protein 1 conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_05205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062459.1">
        <property type="nucleotide sequence ID" value="XM_067207156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KJ70"/>
    <dbReference type="GeneID" id="92361090"/>
    <dbReference type="KEGG" id="loi:92361090"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056614">
        <property type="entry name" value="FAZ1_cons"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23398">
        <property type="entry name" value="FAZ1_cons"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flagellar attachment zone protein 1 conserved" evidence="2">
        <location>
            <begin position="49"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5476226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="226" mass="25666" checksum="85DCD5747B3A9798" modified="2021-09-29" version="1">MQVYVRGSNSENCKGTAGNSDGEGSDRIIDGLRYPRPERQIDQFGFELTTHRLHFHGRDWDIPLSRKRDELTKAFLLDAAAAANEPEDNIRNLRFIVTPTHLDAKMMVRHKAHVSKYEVQKMLSSAKWTHVKALYEPRKKIRRPNRLTKEGVHNDAAHDDQPMLGASRRTTSHNLSFFGRANVGAEGPEFEDHADDGEEPVAYEQQQDAKERRTTSRLLIPVGIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KJB0</accession>
    <name>A0A836KJB0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Guanine nucleotide-binding protein subunit beta-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_02068</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061141.1">
        <property type="nucleotide sequence ID" value="XM_067204104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KJB0"/>
    <dbReference type="SMR" id="A0A836KJB0"/>
    <dbReference type="GeneID" id="92358038"/>
    <dbReference type="KEGG" id="loi:92358038"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF7">
        <property type="entry name" value="F-BOX AND WD-40 DOMAIN PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="297"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="344"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="49"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5472745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="552" mass="57270" checksum="E95177F0A0868A7E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KKS3</accession>
    <name>A0A836KKS3_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_01891</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000022">
        <property type="protein sequence ID" value="KAG5479299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063392.1">
        <property type="nucleotide sequence ID" value="XM_067203933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KKS3"/>
    <dbReference type="SMR" id="A0A836KKS3"/>
    <dbReference type="GeneID" id="92357867"/>
    <dbReference type="KEGG" id="loi:92357867"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.280.10:FF:000014">
        <property type="entry name" value="Mitochondrial glycoprotein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.280.10">
        <property type="entry name" value="Mitochondrial glycoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003428">
        <property type="entry name" value="MAM33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036561">
        <property type="entry name" value="MAM33_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826">
        <property type="entry name" value="COMPLEMENT COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826:SF6">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02330">
        <property type="entry name" value="MAM33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54529">
        <property type="entry name" value="Mitochondrial glycoprotein MAM33-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5479299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="255" mass="29962" checksum="B2CFBCFE9F4A9319" modified="2021-09-29" version="1">MLRRYTMMSRLRETAGVSYRNATGRTAELPVRSEPRRHRKLYQLTMREEREEGLRDFLPPRPLLPVGWKLQHESGSNRFDLFKSVEIRQCGVEELHIITLMETKEYEGTYRMDNGEREEQEYLNFALFMRKRRYPEGGLEFSLTSIDLELVMDALTIHSSQEAFENAKACYGRNGAAVAKKDKLISTGEARRRRASKYSGPMLSELDDDLSDEILNYLDERGVNNAFAEFIIAQAFFFEQEEYINWLRLLRKFSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KL98</accession>
    <name>A0A836KL98_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_04724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000023">
        <property type="protein sequence ID" value="KAG5478491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063152.1">
        <property type="nucleotide sequence ID" value="XM_067206705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KL98"/>
    <dbReference type="GeneID" id="92360639"/>
    <dbReference type="KEGG" id="loi:92360639"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5478491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="157" mass="17870" checksum="01917E06ED581509" modified="2021-09-29" version="1">MLASSVPLRSRIPDIGHQTTASFKWATYTFWYILDPILRRHHSYYRRKVQLDRFLERNSIVTNLTIGVILGATVYFGVVCGTLLPPAVGAKEHSMSENAREVLNLMECDTSKELPAYQLMRVKREIIGKLHAVADEAEVRRQREEAAKLSELLKGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KM16</accession>
    <name>A0A836KM16_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_04132</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062058.1">
        <property type="nucleotide sequence ID" value="XM_067206121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KM16"/>
    <dbReference type="SMR" id="A0A836KM16"/>
    <dbReference type="GeneID" id="92360055"/>
    <dbReference type="KEGG" id="loi:92360055"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="98"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="174"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="262"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5475550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="463" mass="54143" checksum="13BB0F44A16F3EE9" modified="2021-09-29" version="1">MGDIHLPALAAPKGKQSSHPLSKKVDDYTLCQEYAGYIAQLRGLLEETTGPPPAGVRTAEVERRIALIHCALDEVKRLNAEARWRIELRSNQRFLETCERRIKAEEEAEKKRQEAEKQRLAQVEEMRAMQQAYYKERNDRTDAKAHHCRAHNEEVQEQTVMKAETNEERRTRNLANLDAERQRKNKELRDREQARQAYARMLRERQAAKDAQKQAEKTRLAEIHRQEMEAKLIAIRESKRCKWAAKKEASRSKSVLVWRNGEAILETQRKNHDNLVEELEQRQRQQALRYAEEKAEQEAYLQQRQQVHSARQERQQENLIKLLDKRVSRGVEIVKNAEEKKERAEQVKERHAVQYVEAGKLLDEDVRLHLQRARRLQERRTNESLAQNYRRWNHRAARIMKELHDAVAKEAAEAEQLSAAASRQRGVTAHSENQRSWAASEHADIPRCGYLIASLPSPKEFAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KP78</accession>
    <name>A0A836KP78_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription elongation factor 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_06163</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">LSCM4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ELOF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000020">
        <property type="protein sequence ID" value="KAG5480397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063728.1">
        <property type="nucleotide sequence ID" value="XM_067208088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KP78"/>
    <dbReference type="GeneID" id="92362022"/>
    <dbReference type="KEGG" id="loi:92362022"/>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="Zn_ribbon_Elf1"/>
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        <location>
            <begin position="1"/>
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        <location>
            <begin position="139"/>
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        <location>
            <begin position="208"/>
            <end position="248"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
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        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="152"/>
            <end position="162"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009730"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5480397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="273" mass="29126" checksum="3126F05D59E480BF" modified="2021-09-29" version="1">MSDARNEAQPRRGNFASRKARGETGGVKSSSSSKSKEHNYDARRYHQNANTHGIHALRTFDCPVCDSKNTIRVTLNPRLRQGTVWCTYCCSLKPVPPDLPYPSAQVFVPSLENKADVFFRFNEQYAALLRLHMGEQVGESTVPSSSSAAADSTRKRDNKDDGASGGCIRRPRGEETGEHGLFSTYVSSVGTSLLSDAVGQGVTGAAGFFDSDGDDDSSRNVADATPANPEGVSTPSPPRLDGADVPESDLASVATITGVDEEVDVAAFFADSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KPS7</accession>
    <name>A0A836KPS7_9TRYP</name>
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        <recommendedName>
            <fullName evidence="4">Amastin-like surface protein-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000016">
        <property type="protein sequence ID" value="KAG5482331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067207523.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="92361457"/>
    <dbReference type="KEGG" id="loi:92361457"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40741:SF1">
        <property type="entry name" value="AMASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AMASTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5482331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="21825" checksum="5A909B672448125F" modified="2021-09-29" version="1">MLCLRLSLLIFAICITACVTCSILFPLFRLKITLEELNETRLTVYYWYNETVTSVDGGSLIFRYYARDFTCTNQRIAHIAMSVLSVLAASMGGIAVLFLACWALAGPRCCLGVIAYFAILVAFVCSLITLALSGYVYVTDFCGVDSLRKAQYKLVEGFALICTATGGYLILLLLGLILLLWCCRSTSLSDIGTPDYHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KQH1</accession>
    <name>A0A836KQH1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_04969</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="JAFHLR010000014">
        <property type="protein sequence ID" value="KAG5483814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064753.1">
        <property type="nucleotide sequence ID" value="XM_067206944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KQH1"/>
    <dbReference type="SMR" id="A0A836KQH1"/>
    <dbReference type="GeneID" id="92360878"/>
    <dbReference type="KEGG" id="loi:92360878"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000085">
        <property type="entry name" value="Tyrosine--tRNA ligase 1 cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050489">
        <property type="entry name" value="Tyr-tRNA_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006330">
        <property type="entry name" value="PRK08560.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264:SF4">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264">
        <property type="entry name" value="TYROSINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002025"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00005594"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00013160"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5483814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="755" mass="83100" checksum="AC0A8C005E35486B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KQI5</accession>
    <name>A0A836KQI5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_06898</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG5481822.1"/>
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    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
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                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG5483711.1"/>
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    </dbReference>
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        </location>
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        </location>
    </feature>
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        <location>
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        <location>
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        </location>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5483711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1026" mass="108080" checksum="F40FD75A6CA998D2" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KRV0</accession>
    <name>A0A836KRV0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutaredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000020">
        <property type="protein sequence ID" value="KAG5480410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063741.1">
        <property type="nucleotide sequence ID" value="XM_067208101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KRV0"/>
    <dbReference type="SMR" id="A0A836KRV0"/>
    <dbReference type="GeneID" id="92362035"/>
    <dbReference type="KEGG" id="loi:92362035"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015038">
        <property type="term" value="F:glutathione disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000317">
        <property type="entry name" value="Glutaredoxin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694:SF3">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="1">
        <location>
            <begin position="23"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5480410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="107" mass="12295" checksum="9BB643B114734667" modified="2021-09-29" version="1">MNQALDPARAPQFLDSMLRRNRVVLISATYCQFSTKLKMLLIELKHRFVSLEIDIIPNGREVFQEVVARTGVHTVPQVFLNGKYLGGYDDLIALYRKGELSETLEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KSP5</accession>
    <name>A0A836KSP5_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_07036</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM221 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000018">
        <property type="protein sequence ID" value="KAG5481325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064004.1">
        <property type="nucleotide sequence ID" value="XM_067208941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KSP5"/>
    <dbReference type="SMR" id="A0A836KSP5"/>
    <dbReference type="GeneID" id="92362875"/>
    <dbReference type="KEGG" id="loi:92362875"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026755">
        <property type="entry name" value="Fam221a/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31214">
        <property type="entry name" value="PROTEIN FAM221A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31214:SF3">
        <property type="entry name" value="PROTEIN FAM221B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14753">
        <property type="entry name" value="FAM221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="183"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="381"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="183"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5481325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="458" mass="49249" checksum="6410AAD80FFFBDD1" modified="2021-09-29" version="1">MPPKTKLSSSSPSCSAAARPQRGSMPTRGRVGGASSSTAPLSLAHRGLTTATKTMTVRDRGTVAPSGALAYGDIVESDEIHDEIRELGTQVKSMIAQHLPRHGTSEEQVMWGVRQFGPSKESRRVLNKENDAARLAWETGVYCLWRCLEKPRLSGANHDFCCRIGYQHMCFCGHTLAVHTTPGRAANSSAAQANRGSGRERDARDGDGGKTPSRGFTTAPATDAQLTQWKAPCEEAGCSCGRYRYVPNTPLEIGEGWLTRRANWKASEWSAKCRCGHGHKMHDAKTMRCKSCGGCPGFTSAFLCVVCDLPWEAHDTVWESEGVRLGEGRPVCEGYAPLAGIDWDVREAVLTDVSMSGRIEPPAAHLALQQRSSNTAAKVASSARRGIASGPRSSTVGARDGKGGPSVGVLPAITASCVADPILDVEYCRFCATVYKRPESKFCSQCGEPRPQRPATLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KSS9</accession>
    <name>A0A836KSS9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_07893</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000013">
        <property type="protein sequence ID" value="KAG5484327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064820.1">
        <property type="nucleotide sequence ID" value="XM_067209770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KSS9"/>
    <dbReference type="GeneID" id="92363704"/>
    <dbReference type="KEGG" id="loi:92363704"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="173"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5484327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="277" mass="30478" checksum="5DC32D4DA7E3619F" modified="2021-09-29" version="1">MASASTVYVKGACATMRDDTAEARWGKLDEVHKMLSSQSDSKELFTKFTVLRSVVGEAKPVFSDSVLTRVKVSCEEQTSTEAEECDEFEPVSMHVVAYFNYTQFMEEMAELVVQARLLRSIGMEGSGLRFQRRKRNISASRDEPRAGSSGYTGKPTIKAAGHEPTYQPVTLIPVGALRLRRVAKVSGAGELAEFVAKIERVCVVKSMCCFGVGRILMTAAEKIARDAFHVRWALLYAHLSSKEFYAKTGYAPKEGQTCMGLHAPHVLMVKCLAGASM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KT15</accession>
    <name>A0A836KT15_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kringle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_04390</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062584.1">
        <property type="nucleotide sequence ID" value="XM_067206375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KT15"/>
    <dbReference type="SMR" id="A0A836KT15"/>
    <dbReference type="GeneID" id="92360309"/>
    <dbReference type="KEGG" id="loi:92360309"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="CDD" id="cd00108">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.20.10">
        <property type="entry name" value="Plasminogen Kringle 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000001">
        <property type="entry name" value="Kringle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013806">
        <property type="entry name" value="Kringle-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038178">
        <property type="entry name" value="Kringle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050759">
        <property type="entry name" value="Serine_protease_kringle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24261:SF7">
        <property type="entry name" value="KRINGLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24261">
        <property type="entry name" value="PLASMINOGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00051">
        <property type="entry name" value="Kringle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00130">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57440">
        <property type="entry name" value="Kringle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50070">
        <property type="entry name" value="KRINGLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0420">Kringle</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032557030" description="Kringle domain-containing protein" evidence="5">
        <location>
            <begin position="28"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1099"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="domain" description="Kringle" evidence="6">
        <location>
            <begin position="53"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1063"/>
            <end position="1085"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5477173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1141" mass="120520" checksum="49C5AD34A402F34C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KTX7</accession>
    <name>A0A836KTX7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_06342</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000007">
        <property type="protein sequence ID" value="KAG5486876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065670.1">
        <property type="nucleotide sequence ID" value="XM_067208265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KTX7"/>
    <dbReference type="SMR" id="A0A836KTX7"/>
    <dbReference type="GeneID" id="92362199"/>
    <dbReference type="KEGG" id="loi:92362199"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="7"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="73"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="268"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="270"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="281"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="310"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5486876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="351" mass="37876" checksum="453DFD47761A9281" modified="2021-09-29" version="1">MEGGRRYSFFISGIGRHVSGDVVENYFRDYGTGVRLQLKRDKNGLSLGYGWLTFDHVDVKRVIASQHELDGSPLMLSYQPDKSLPQPSPAAPPQPPPSSPPTTAAKQQGRPQEYSPQYKRYRDETRRTQAHTSSRTMQIQEDRIPPRPKTPPSLPREALKAEAGPSAVPQTVPSQHFSSSTLESTAQPVFVCIPLSICPGAFLHDPRVFCCTLDPSQVGKLSIIATAMPPVTAAEHHPKHSTYIGQDVPQLQYSTYASLYSAQAPLQPSLTAPPLASGPTPSTPPPPGPPPPKTVALFRETVQPSQGSTLPPPPPPPGPPPTLNRSSETFLQAPPPPGPPPPPGPPPRRYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KUP6</accession>
    <name>A0A836KUP6_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_07528</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000004">
        <property type="protein sequence ID" value="KAG5487849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066046.1">
        <property type="nucleotide sequence ID" value="XM_067209414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KUP6"/>
    <dbReference type="GeneID" id="92363348"/>
    <dbReference type="KEGG" id="loi:92363348"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13037">
        <property type="entry name" value="FORMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13037:SF24">
        <property type="entry name" value="POLYCOMB PROTEIN PCL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="41"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="284"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="497"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="530"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="587"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1011"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="284"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="297"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="311"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="322"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="537"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="596"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="606"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5487849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1073" mass="115308" checksum="2D59B644188E3287" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KUT1</accession>
    <name>A0A836KUT1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone deacetylase</fullName>
            <ecNumber evidence="3">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_07420</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">LSCM4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone deacetylase family. HD type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="3"/>
    <dbReference type="EMBL" id="JAFHLR010000008">
        <property type="protein sequence ID" value="KAG5486487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065553.1">
        <property type="nucleotide sequence ID" value="XM_067209310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KUT1"/>
    <dbReference type="SMR" id="A0A836KUT1"/>
    <dbReference type="GeneID" id="92363244"/>
    <dbReference type="KEGG" id="loi:92363244"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09992">
        <property type="entry name" value="HDAC_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF5">
        <property type="entry name" value="HISTONE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="10">
        <location>
            <begin position="196"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5486487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="607" mass="65703" checksum="1EDBCDACF2427232" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KUW1</accession>
    <name>A0A836KUW1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_08268</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <source>
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</entry>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
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            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
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            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
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            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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                <person name="Bates M.D."/>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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            <authorList>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000012">
        <property type="protein sequence ID" value="KAG5484883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064995.1">
        <property type="nucleotide sequence ID" value="XM_067209535.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92363469"/>
    <dbReference type="KEGG" id="loi:92363469"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049453">
        <property type="entry name" value="Memb_transporter_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30509:SF9">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN MDTO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30509">
        <property type="entry name" value="P-HYDROXYBENZOIC ACID EFFLUX PUMP SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13515">
        <property type="entry name" value="FUSC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="423"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="473"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Integral membrane bound transporter" evidence="8">
        <location>
            <begin position="767"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="225"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1095"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1155"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1289"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1605"/>
            <end position="1645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1661"/>
            <end position="1709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1866"/>
            <end position="1897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1101"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1302"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1614"/>
            <end position="1624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1629"/>
            <end position="1645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1666"/>
            <end position="1675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1683"/>
            <end position="1695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1885"/>
            <end position="1897"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5484883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1972" mass="206942" checksum="5E079819DF38DC50" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836L1M5</accession>
    <name>A0A836L1M5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fatty acid desaturase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_06544</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000010">
        <property type="protein sequence ID" value="KAG5485588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065172.1">
        <property type="nucleotide sequence ID" value="XM_067208461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836L1M5"/>
    <dbReference type="GeneID" id="92362395"/>
    <dbReference type="KEGG" id="loi:92362395"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03507">
        <property type="entry name" value="Delta12-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32100">
        <property type="entry name" value="OMEGA-6 FATTY ACID DESATURASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="206"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="256"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="2">
        <location>
            <begin position="98"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5485588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="394" mass="45430" checksum="D9C62C7E84E1D3F4" modified="2021-09-29" version="1">MKSVLKAGREKDVDVVVPPKELTIKQIQDRIPAKYFERSAVWSMYYVLRDICQVLALYLIMYRAVMPVLTAIEGVVYGVAGANIVTWTVVGAVKFAVWTVFGIAQGLNGFAIFVLAHECGHQAFSAYRSLNDTVGFLLDSAILVPYHSWRISHGQHHKHTNHLTKDTAFVPRKEQRVMDLVEETPLAMLWNMFVIFTFGWPAYLLANIASQDYDRRTNHFEPSSPLFQKDDWLDIVLSDVGVVAVLLILGLCTYHYGAYNVVCWYVVPYLWTNFWLLYVTYLQHSDLRIPHYAPEHWTFVRGAIAAVDRDYGYVINNWLHYINNSHVVHHLFSQMPFYHAIKVTRHHIKDIVGDAYVVDDRSLVTMLCETWRECRYVIPSEGVSVFYGFTTKHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FP75</accession>
    <name>A0A836FP75_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine aminopeptidase S33 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_01603</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059342.1">
        <property type="nucleotide sequence ID" value="XM_067203651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836FP75"/>
    <dbReference type="SMR" id="A0A836FP75"/>
    <dbReference type="GeneID" id="92357585"/>
    <dbReference type="KEGG" id="loi:92357585"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF81">
        <property type="entry name" value="PROTEIN ABHD13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="2">
        <location>
            <begin position="153"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5466452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="394" mass="42813" checksum="E54B35286318B5EB" modified="2021-09-29" version="1">MSFGGFLLSAVLYLALVAVFVSLLLHIMSYRYRSQQNRLLYYPQIPPESREVCDDPVALGIPYAERVCVTTADKVRLWGYMLWPAPAPPLEKGSNGSSHDSIGNASPNVAAGVGGVHVEVDASGFGTDSTSAGSTISASNRSVTLSSGMPSFVMLYFHGNAGNVGHRLPLAQAFVAHLKCAVMMVDYRGFGLSDDSEQTQETLELDAQACFDYLWQDPRVPRDRIVVMGTSLGGAVAIHLAANKRYARRICAVIVENSFSSIGDMASALSRPILTKVVSQCPGLAVGLFEYYIKPLALRIDWNSAQKVSKVVVPMLFLSGMRDEIVPPEQMRTLYKAATKCLRDGNGGDLTVPLRRFHEFEDGRHNNLPLMPGYMSALQDFVAEVRNAGTAAVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FPD6</accession>
    <name>A0A836FPD6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_01724</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059462.1">
        <property type="nucleotide sequence ID" value="XM_067203771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836FPD6"/>
    <dbReference type="SMR" id="A0A836FPD6"/>
    <dbReference type="GeneID" id="92357705"/>
    <dbReference type="KEGG" id="loi:92357705"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01856">
        <property type="entry name" value="YlqF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001924">
        <property type="entry name" value="GTP-binding protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782:SF4">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="4">
        <location>
            <begin position="168"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="409"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="354"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5466572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="464" mass="51494" checksum="D2FEB97F4512005E" modified="2021-09-29" version="1">MRATVRQCNVFDPAFMRKVKRTLNAYKDSMETSTKKSMSREAFVDIDEKGAAWYLGHMQSAATMLAEKVKDADFILEIRDARLPFTTENPNIRKLTAGKPRLIIFNKAELSNEDSNRAIQEYYERHGAFALFTSARRCWRDVVEAVQRFTTHILPPLPFKTVAHVGLVVGMPNVGKSTLINSLRLAHEYQFHREDFRRSRSPETVSITPGTTRGMKLVPLSKDPPVVLYDTPGLTLPGCFTKESGLKLAACGIIPTNNVSLPQGMVARYIYDILVASGSSEHMAECLHLPRVPISFDDCVAMICERSGTSGQTEMGNLDPVRAHRFFVHDFIMGNLGKITLDVLPRRMLRSAQSSAPLLESRSSATDADGAHTAAGDDDGCVWTHHVETSDVVERYPDHMRDVLESLKGPLHHDGVPRRRSMSSVTAVTGSPGCTVISRKKGPISRATGFDEQLKRSTRLAPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FRR2</accession>
    <name>A0A836FRR2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Treble clef zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_01054</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059769.1">
        <property type="nucleotide sequence ID" value="XM_067203119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836FRR2"/>
    <dbReference type="SMR" id="A0A836FRR2"/>
    <dbReference type="GeneID" id="92357053"/>
    <dbReference type="KEGG" id="loi:92357053"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025487">
        <property type="entry name" value="DUF4379"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37317">
        <property type="entry name" value="BLR8090 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37317:SF1">
        <property type="entry name" value="ZINC-RIBBON DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14311">
        <property type="entry name" value="DUF4379"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Treble clef zinc finger" evidence="2">
        <location>
            <begin position="82"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5467967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="197" mass="21859" checksum="F279D07DCFE3119A" modified="2021-09-29" version="1">MPPYGPSYSCGARRMPAMACVASMRVGPSVGNALQSSIQYTLCVPLRHKASTIRVANRKKVEMFVGKRYHLPTRLRVAAPDIAAEWDHEKNPMHLYPDIVSIGYMYPVHWKCQGCANSYQMSVEKRVVRGGGCPVCEDRELNRSMALNTAAMDTGSAHRGEADAPSEGVMPPPLLPGEENRALRPKRTTMLNLRTKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FTR5</accession>
    <name>A0A836FTR5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ribosomal protein L37</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_01711</name>
        <name evidence="13" type="ORF">LSCM4_02519</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">LSCM4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the eukaryotic ribosomal protein eL37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059449.1">
        <property type="nucleotide sequence ID" value="XM_067203758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836FTR5"/>
    <dbReference type="SMR" id="A0A836FTR5"/>
    <dbReference type="GeneID" id="92357692"/>
    <dbReference type="KEGG" id="loi:92357692"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.30:FF:000004">
        <property type="entry name" value="Ribosomal protein L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001569">
        <property type="entry name" value="Ribosomal_eL37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018267">
        <property type="entry name" value="Ribosomal_eL37_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10768">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10768:SF0">
        <property type="entry name" value="RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01907">
        <property type="entry name" value="Ribosomal_L37e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01077">
        <property type="entry name" value="RIBOSOMAL_L37E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9 11" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5466559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG5469122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="83" mass="9819" checksum="CBA1D9A225EE0F54" modified="2021-09-29" version="1">MTKGTTSMGQRHGRTHILCRRCGRNAYHVQWERCAACAYPRASRRRYNWSVKAIKRRRTGTGRCRYLKVVNRRIANHFKTPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G5E6</accession>
    <name>A0A836G5E6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CAAX prenyl protease</fullName>
            <ecNumber evidence="9">3.4.24.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_04079</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Proteolytically removes the C-terminal three residues of farnesylated proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic side chains and P3' is any C-terminal residue.</text>
            <dbReference type="EC" id="3.4.24.84"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8 9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase M48A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.84" evidence="9"/>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062005.1">
        <property type="nucleotide sequence ID" value="XM_067206068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G5E6"/>
    <dbReference type="SMR" id="A0A836G5E6"/>
    <dbReference type="GeneID" id="92360002"/>
    <dbReference type="KEGG" id="loi:92360002"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07343">
        <property type="entry name" value="M48A_Zmpste24p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2010.10:FF:000016">
        <property type="entry name" value="CAAX prenyl protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027057">
        <property type="entry name" value="CAXX_Prtase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032456">
        <property type="entry name" value="Peptidase_M48_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10120">
        <property type="entry name" value="CAAX PRENYL PROTEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16491">
        <property type="entry name" value="Peptidase_M48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 8 9" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 1 N-terminal" evidence="11">
        <location>
            <begin position="30"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M48" evidence="10">
        <location>
            <begin position="219"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="369"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5475497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="427" mass="49197" checksum="418B7369BF498AED" modified="2021-09-29" version="1">MSPTQNLFLQAAVISLNVIGLWDAYLVLRQRRAYRTKKMPSYFRKDITDEEFAKAQAYEGERSTLSLLQHVKGLVVSNVSIFLRLPARLYYFVAQRSSLLPGSFLHNYATAVAGELISTLIDLPFSYYENFHVEERHGLNKMTKTEFVKDVVKKLFLHVTLLYPLQIKLIQYVVQHFGARFPLYLFCGMSVMLVFFLLALPTVIQPLFNRFTPLDAESPLHKKIEHLSRELSFPLKKVFVVDGSRRSHHSNAYFYGFGSYKRIVLYDTILEQLKDDDESIIAVLCHELGHWQHNHIYVNLAVALSQLLLISYGARLVLFDKRVYEAFGFHEADPVIGLNIFADIIYGTLSTFIGYGFCYISRRHEFQADRFAVTHNHGEGMKKALLVITKENRASLTPDPLYSALHFTHPPVLERLQAIDAQLQKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G6X8</accession>
    <name>A0A836G6X8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_01721</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059459.1">
        <property type="nucleotide sequence ID" value="XM_067203768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G6X8"/>
    <dbReference type="SMR" id="A0A836G6X8"/>
    <dbReference type="GeneID" id="92357702"/>
    <dbReference type="KEGG" id="loi:92357702"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051131">
        <property type="entry name" value="NEK_Ser/Thr_kinase_NIMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899">
        <property type="entry name" value="CAMK FAMILY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
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        <location>
            <begin position="69"/>
            <end position="326"/>
        </location>
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            <begin position="376"/>
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            <dbReference type="ARBA" id="ARBA00022679"/>
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            <dbReference type="ARBA" id="ARBA00022741"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
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            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5466569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="478" mass="54782" checksum="C5AAF293E0042E6E" modified="2021-09-29" version="1">MPSKEGEQGSASTELLNQYAKYFPHVLFTSSDAFEKYATTLDLETYTKCVDLPEGEESPESRNPREHMYVLTTLVGRNPTTAAFVAIRGSNPSEKVVAKFVMLNDERQATYARSELHCLAACKHFGIVKHFDDFKSDDKLLLIMEYGSGGDLNKQIKQRLKEHLPFQEYEVGLLFYQIVLALDEVHSRRMMHRDLKSANIFLMPTGIIKLGDFGFSKQYNDSVSLDVASSFCGTPYYLAPELWERKRYSKKADMWSLGVILYELLTLHRPFKGPSQREIMQQVLYGKYDPFPCPVSSSMRALLDPLLSKNPTERPTTQQLLHTEFLKYVANLFQDIVRHSETISPTDRAEILKQLQESSERAPLPSSIRYGVITSQVTHGGYLYKYGSDYRWKKRYFYIGDGQLRISLSENPEKDGVAPKSVNLETVSDVFPVPEVYSQKHPNQLVVWFNNGQKIIAYASTMEDRDMWISKFHRACGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G7D0</accession>
    <name>A0A836G7D0_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_00903</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067202971.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="loi:92356905"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="95"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="236"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="390"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
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        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="248"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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            <end position="277"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="289"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="311"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="324"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="393"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5467819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="573" mass="60845" checksum="1BB093D5794DC874" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G8H9</accession>
    <name>A0A836G8H9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Steroid 5-alpha reductase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_04500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
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            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067206484.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="loi:92360418"/>
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        <property type="component" value="Chromosome 25"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5477282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="28640" checksum="7F1D11ED91413004" modified="2021-09-29" version="1">MSAPARTNAEPGSAVEEESKKLALKSLFQRCVRKWMDVVDYLSTSFLGGPRCIKFAHVINFQKCTTLFVCGAMMWRSGNFSATAMTYTALHGSYGLCWYLKHLVFPDPRWDPKITIASALCAFTAVLGPYWMIAYNAIMQGGERSNAALCAATVVYALGLAIMMGADGQKYFVLRARKGLITDGFFARTRNPNYLGEVMIYGSFAFVSGRTSSWVILLTIWTGLFLPSMLCKDIRMSRHAGWKAYAARTGLFFPRIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G966</accession>
    <name>A0A836G966_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_00868</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059586.1">
        <property type="nucleotide sequence ID" value="XM_067202936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G966"/>
    <dbReference type="SMR" id="A0A836G966"/>
    <dbReference type="GeneID" id="92356870"/>
    <dbReference type="KEGG" id="loi:92356870"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052097">
        <property type="entry name" value="SET-MYND_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46165">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46165:SF2">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="5">
        <location>
            <begin position="223"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5467784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="700" mass="77423" checksum="D6991FB974042957" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GAZ9</accession>
    <name>A0A836GAZ9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_02682</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
            <location evidence="1 8">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the dynein light chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5469994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060260.1">
        <property type="nucleotide sequence ID" value="XM_067204708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GAZ9"/>
    <dbReference type="SMR" id="A0A836GAZ9"/>
    <dbReference type="GeneID" id="92358642"/>
    <dbReference type="KEGG" id="loi:92358642"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21452">
        <property type="entry name" value="DLC-like_DYNLL1_DYNLL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.740.10:FF:000001">
        <property type="entry name" value="Dynein light chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886:SF35">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 8" id="KW-0243">Dynein</keyword>
    <keyword evidence="4 8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5469994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="91" mass="10587" checksum="CFB776CA23DBF4F6" modified="2021-09-29" version="1">MYNNDHKATVKNADMPEDMQADAIEVTLQAMEKFNIEKDIAAYIKKEFDKKYQPTWHCIVGRNFGSFVTHDTHCFLYFYLGQVAVLLFKCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GB47</accession>
    <name>A0A836GB47_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cilia- and flagella-associated protein 300</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_03197</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">LSCM4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CFAP300 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060763.1">
        <property type="nucleotide sequence ID" value="XM_067205211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GB47"/>
    <dbReference type="GeneID" id="92359145"/>
    <dbReference type="KEGG" id="loi:92359145"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029416">
        <property type="entry name" value="CFAP300"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31078">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31078:SF1">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14926">
        <property type="entry name" value="CFAP300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="56"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5471646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="388" mass="42728" checksum="283E506AFEDA0CBB" modified="2021-09-29" version="1">MFVFQRAEPSSTAAQAPACASPVDVEPYRGLFVKWGLLQPGGSEEWHMHTYRYSSSSSSSETPSFIEGASSAQTRTSLSPSRTANTSVATVSAFALRFHHGVAADFLRSLFASPCVHSALVGDDAHRAQCSAGDDKLQFRPLTCRWTTLQPLRHGLVDAKVVRQVVCDVGGAALRSFDTFGYLLPTVKRSEELLPHGEVISDELRALFLRAHSRPCAQGSGVCGDLCDDRDPDDAGDDDDEDMWGSMSRSKLPLRRLRAVFGNESREEFLYHILWRLIAGSGPLNQFEDDAAVYLDAARALYRYLIRSLHVCEETEQGANGDLAGLEVPDGTSPRYGAVVDTCVYEVFKVPGMTLFPRSDGVYPSNLNYCYVAVHPSEQTVTVWYHRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GCY3</accession>
    <name>A0A836GCY3_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_01988</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061062.1">
        <property type="nucleotide sequence ID" value="XM_067204025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GCY3"/>
    <dbReference type="SMR" id="A0A836GCY3"/>
    <dbReference type="GeneID" id="92357959"/>
    <dbReference type="KEGG" id="loi:92357959"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5472666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="397" mass="45806" checksum="C2EB018F19D615D2" modified="2021-09-29" version="1">MLRRTSLRLLGYTPINPDTSPMLMYSQCHWHYNLPQGMERPHSINRSLPAPYQPHHSSVNKYRGVWISTEMHPAFLVGLEPQLKKLPHGRVVPQTPVAEVIDDFEKLSPLIDDAAARDGWLAKIFQHCAFRRSGAEAMALWDKHCAPRFMRDDSTSVPPLPLVQAILFCCSKSDNAGWRPIFTKCLKDGWNYTPSFDTPQWSYLLKSLGRQGDEVGVRLVLEEMADVQADLDRVEARSLVYALNAVQDKAIYNYVKKYLFYLGERKVKFLRITYADLRGHGAEKLRVPLKENDSMFYHVCWHASIRQPRQFSPRQLYFDYTPSHLATSGHSPNAKVDGIVKDKIEKWKAEGLLPEDYVHEDRVYDRTAAFKSVARQEKWKKVPRIVKSKRFGYTGEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GH66</accession>
    <name>A0A836GH66_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nuclear pore complex protein (NUP155)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_00740</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the non-repetitive/WGA-negative nucleoporin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058916.1">
        <property type="nucleotide sequence ID" value="XM_067202815.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836GH66"/>
    <dbReference type="GeneID" id="92356749"/>
    <dbReference type="KEGG" id="loi:92356749"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036228">
        <property type="term" value="P:protein localization to nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000972">
        <property type="term" value="P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.450:FF:000006">
        <property type="entry name" value="Putative nuclear pore complex protein (NUP155)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.450">
        <property type="entry name" value="Nucleoporin, helical domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007187">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014908">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004870">
        <property type="entry name" value="Nucleoporin_Nup155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042533">
        <property type="entry name" value="Nucleoporin_Nup155_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10350">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10350:SF6">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03177">
        <property type="entry name" value="Nucleoporin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08801">
        <property type="entry name" value="Nucleoporin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like N-terminal" evidence="7">
        <location>
            <begin position="58"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like C-terminal" evidence="6">
        <location>
            <begin position="765"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1022"/>
            <end position="1049"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5465285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1306" mass="143431" checksum="164209D22B866C7D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GI40</accession>
    <name>A0A836GI40_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_05686</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000016">
        <property type="protein sequence ID" value="KAG5482427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064433.1">
        <property type="nucleotide sequence ID" value="XM_067207619.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836GI40"/>
    <dbReference type="GeneID" id="92361553"/>
    <dbReference type="KEGG" id="loi:92361553"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008574">
        <property type="term" value="F:plus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00106">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1480.30:FF:000001">
        <property type="entry name" value="Putative kinesin"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000133">
        <property type="entry name" value="Putative kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1480.30">
        <property type="entry name" value="Designed four-helix bundle protein"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047149">
        <property type="entry name" value="KIF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970:SF12">
        <property type="entry name" value="KINESIN FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="8">
        <location>
            <begin position="12"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2467"/>
            <end position="2496"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="393"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="513"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="604"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="724"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="784"/>
            <end position="2362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="2467"/>
            <end position="2477"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="104"/>
            <end position="111"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5482427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="2510" mass="276069" checksum="9A38F0B6A2D9330C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GIJ1</accession>
    <name>A0A836GIJ1_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_02179</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="89" mass="9605" checksum="16A29EA76769391D" modified="2021-09-29" version="1">MTSGNWLVLFVPGNDGVTADRRSVEAVTVIASFDSLVRVSTEVVSAYQVVPAYVLCDESPSLCKRFKVANSSAKLVILSGGRMYSYPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836GJ84_9TRYP</name>
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            <fullName evidence="5">Bardet-Biedl syndrome 1 N-terminal domain-containing protein</fullName>
        </recommendedName>
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    <gene>
        <name evidence="3" type="ORF">LSCM4_01621</name>
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    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Discoba</taxon>
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            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="C:microtubule organizing center"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="GAE_BBS1"/>
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        <property type="entry name" value="BARDET-BIEDL SYNDROME 1 PROTEIN"/>
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    </dbReference>
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            <begin position="17"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Bardet-Biedl syndrome 1 protein GAE" evidence="2">
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    </evidence>
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            <dbReference type="Pfam" id="PF23304"/>
        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="593" mass="64031" checksum="BC82BCB707B83FA7" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">J domain-containing protein</fullName>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061427.1">
        <property type="nucleotide sequence ID" value="XM_067205490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GJH8"/>
    <dbReference type="GeneID" id="92359424"/>
    <dbReference type="KEGG" id="loi:92359424"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="139"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5473424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="364" mass="42093" checksum="BEF0B7629E9A878E" modified="2021-09-29" version="1">MFSRGVNEDVLKSEGHNVPKPTTETEQANGEKYKMKLWHNYVDPQHKNHERPVVDVSSPFNVLDEAHQARRYGVQKVAFGFLSLNEFIGVHEEVPYTESHHTSEIFRLWMAGLNVWHMNYFIARAQVSGNATGNPRTKFAWAIAMLMGTIRVNIAGMIGVGGYFYSYEYLYTHGPKPFRIRDPTPNGWKRAWDDGQECYLPRAAASVFPAIGYAFFMGRWKKAGFWFMTTLMAGLYYEYARRNILFGSRLFYSYLANQDSQRQAAWGSLAPNLKHRVDPDTNRNESVAQFKYFRITSGTMQDTVWNNCTHETQPLARGGIKILNPYFNWLKAPQQYNAKPWKVKNDMWEMPQVMNAQMRSGAMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GJR8</accession>
    <name>A0A836GJR8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bacterial surface antigen (D15) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_03628</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAM50/omp85 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061562.1">
        <property type="nucleotide sequence ID" value="XM_067205625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GJR8"/>
    <dbReference type="GeneID" id="92359559"/>
    <dbReference type="KEGG" id="loi:92359559"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.50:FF:000013">
        <property type="entry name" value="Putative Tob55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.50">
        <property type="entry name" value="membrane protein fhac: a member of the omp85/tpsb transporter family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000184">
        <property type="entry name" value="Bac_surfAg_D15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039910">
        <property type="entry name" value="D15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815:SF18">
        <property type="entry name" value="SORTING AND ASSEMBLY MACHINERY COMPONENT 50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815">
        <property type="entry name" value="SORTING AND ASSEMBLY MACHINERY SAMM50 PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01103">
        <property type="entry name" value="Omp85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="domain" description="Bacterial surface antigen (D15)" evidence="6">
        <location>
            <begin position="253"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5473559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="473" mass="52451" checksum="13AA4F6E3B829BD9" modified="2021-09-29" version="1">MAETTPPTVNISEDDLKAALKMPIRAHVRLVGIEKTHPDVVARDLETIKRCHTMQEAVETVTEIRSRWISTGIFRNVQYNFEPTADGERNDICIRLDVVEEKPKKSIGVFTTDTSIPEITVALENILGGRYSVKGNYIPPASRVHSISFSFLSNVPFIGQNAEYYIGRKTENKTYHLANAERVEEVRATTTNRKGKLASEVSVGFQRRTLLTKHMKDIPVGDTVDFSATDKGYIRHQFTITDVAHHANPFLYNMYPLPIYGSQVSFCNEFAGGPVGGDFSFLKSEFQGSKYIPLGPFFALQLSAKLAGIYPFFGNRIPLNDRLFLSNCHVRGFKSVGPSTLDGEGNASRFAATGGNALWATSLSLNFPFLFFPNNGIASMHLFANAGNARMIDSLDALKDGYRWLRHCACSVGAGIVITRIPLLGVAPSGRFELNMSIPIGIDKQGNIVCRNGRKSLFDRFRFGLVWSSNFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GKL3</accession>
    <name>A0A836GKL3_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_04900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000014">
        <property type="protein sequence ID" value="KAG5483747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064686.1">
        <property type="nucleotide sequence ID" value="XM_067206877.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836GKL3"/>
    <dbReference type="GeneID" id="92360811"/>
    <dbReference type="KEGG" id="loi:92360811"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1096"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1132"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1193"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1286"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1392"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1544"/>
            <end position="1694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1733"/>
            <end position="1959"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1980"/>
            <end position="2000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1193"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1228"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1297"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1311"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1345"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1400"/>
            <end position="1411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1416"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1446"/>
            <end position="1455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1550"/>
            <end position="1565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1573"/>
            <end position="1585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1587"/>
            <end position="1597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1621"/>
            <end position="1656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1741"/>
            <end position="1772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1829"/>
            <end position="1839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1849"/>
            <end position="1864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1865"/>
            <end position="1878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1881"/>
            <end position="1894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1903"/>
            <end position="1919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1986"/>
            <end position="2000"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5483747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="2000" mass="213728" checksum="884BEF636D94F83D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GLR0</accession>
    <name>A0A836GLR0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_02718</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060293.1">
        <property type="nucleotide sequence ID" value="XM_067204741.1"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A836GLR0"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:hydrolase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:RNA binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17957">
        <property type="entry name" value="DEADc_DDX52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002768">
        <property type="entry name" value="ATP-dependent DEAD/H RNA helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002772">
        <property type="entry name" value="ATP-dependent DEAD/H RNA helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044764">
        <property type="entry name" value="DDX52/Rok1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF15">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
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            <end position="510"/>
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            <end position="108"/>
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            <end position="566"/>
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            <begin position="575"/>
            <end position="587"/>
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    </feature>
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            <dbReference type="ARBA" id="ARBA00012552"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5470027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="587" mass="64842" checksum="61A7BF1C22BA52A8" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GML6</accession>
    <name>A0A836GML6_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5477916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062823.1">
        <property type="nucleotide sequence ID" value="XM_067207255.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92361189"/>
    <dbReference type="KEGG" id="loi:92361189"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="244"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1168"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1317"/>
            <end position="1363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3033"/>
            <end position="3064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1170"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1327"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1344"/>
            <end position="1363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5477916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="3180" mass="353613" checksum="9E28F632CB12C4B8" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GMY9</accession>
    <name>A0A836GMY9_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5478081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062988.1">
        <property type="nucleotide sequence ID" value="XM_067207420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GMY9"/>
    <dbReference type="GeneID" id="92361354"/>
    <dbReference type="KEGG" id="loi:92361354"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5478081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="519" mass="55773" checksum="3E6D560DBE02E242" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GNU8</accession>
    <name>A0A836GNU8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein transport protein Sec24C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_04487</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">LSCM4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062680.1">
        <property type="nucleotide sequence ID" value="XM_067206471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GNU8"/>
    <dbReference type="SMR" id="A0A836GNU8"/>
    <dbReference type="GeneID" id="92360405"/>
    <dbReference type="KEGG" id="loi:92360405"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000073">
        <property type="entry name" value="Protein transport protein Sec24C, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000133">
        <property type="entry name" value="Protein transport protein Sec24C, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF4">
        <property type="entry name" value="SECRETORY 24CD, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="5">
        <location>
            <begin position="314"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="6">
        <location>
            <begin position="399"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="8">
        <location>
            <begin position="640"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="7">
        <location>
            <begin position="735"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="133"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5477269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1011" mass="111067" checksum="23E691477F824595" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GPA3</accession>
    <name>A0A836GPA3_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000010">
        <property type="protein sequence ID" value="KAG5485637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065221.1">
        <property type="nucleotide sequence ID" value="XM_067208510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GPA3"/>
    <dbReference type="GeneID" id="92362444"/>
    <dbReference type="KEGG" id="loi:92362444"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5485637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="144" mass="15940" checksum="5348FB9ED3B743DC" modified="2021-09-29" version="1">MLTKKAEEPMSPIGASRQPSREPSCAPFDQWQDREPAADDTTCPLRQPMVVPAESKVVVLLHAYETAARNLEEVKQVTTEHSRCGTATSGHTSVIWYALQPLRWWIESCVRPAQLHVSRARSKSAERRIGDDASNADGETLGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GRB4</accession>
    <name>A0A836GRB4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="8">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LSCM4_03081</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RAD25/XPB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="8"/>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060651.1">
        <property type="nucleotide sequence ID" value="XM_067205099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GRB4"/>
    <dbReference type="SMR" id="A0A836GRB4"/>
    <dbReference type="GeneID" id="92359033"/>
    <dbReference type="KEGG" id="loi:92359033"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000112">
        <property type="term" value="C:nucleotide-excision repair factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18789">
        <property type="entry name" value="SF2_C_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002931">
        <property type="entry name" value="DNA repair helicase XPB-R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050615">
        <property type="entry name" value="ATP-dep_DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032438">
        <property type="entry name" value="ERCC3_RAD25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032830">
        <property type="entry name" value="XPB/Ssl2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274">
        <property type="entry name" value="RAD25/XP-B DNA REPAIR HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16203">
        <property type="entry name" value="ERCC3_RAD25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13625">
        <property type="entry name" value="Helicase_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="230"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="502"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="744"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG5470385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="806" mass="88850" checksum="F44CD2C831878DC8" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GUH9</accession>
    <name>A0A836GUH9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glycoside hydrolase family 31 TIM barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_00443</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycan metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058626.1">
        <property type="nucleotide sequence ID" value="XM_067202525.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836GUH9"/>
    <dbReference type="GeneID" id="92356459"/>
    <dbReference type="KEGG" id="loi:92356459"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090599">
        <property type="term" value="F:alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF54">
        <property type="entry name" value="BCDNA.GH04962"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="9">
        <location>
            <begin position="554"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1299"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1369"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1299"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1373"/>
            <end position="1382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5464995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1467" mass="157699" checksum="749888122A8C045D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GUL2</accession>
    <name>A0A836GUL2_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000020">
        <property type="protein sequence ID" value="KAG5480449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063780.1">
        <property type="nucleotide sequence ID" value="XM_067208140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GUL2"/>
    <dbReference type="GeneID" id="92362074"/>
    <dbReference type="KEGG" id="loi:92362074"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5480449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="117" mass="12851" checksum="B776FB0C563DD4C3" modified="2021-09-29" version="1">MSKAADKAVVEGVTPVSNKEDSLPFLARMINHLLTPGSSLSPIVWISFNLVMLALLGVWLMFVFTMPKNIHVWAFGFLGLGLTASTNWLMKIVFSSGLDFASQQHRDAVAESGKKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GUX5</accession>
    <name>A0A836GUX5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ER membrane protein complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_06861</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000017">
        <property type="protein sequence ID" value="KAG5481786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064146.1">
        <property type="nucleotide sequence ID" value="XM_067208772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GUX5"/>
    <dbReference type="SMR" id="A0A836GUX5"/>
    <dbReference type="GeneID" id="92362706"/>
    <dbReference type="KEGG" id="loi:92362706"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039856">
        <property type="entry name" value="EMC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12760">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5481786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="317" mass="36374" checksum="AD2CF43E4CD78CD9" modified="2021-09-29" version="1">MSDPEPHLSLQSLTPVDLKQLSRQQKIMLVQNYRASGARNANKMLFLATDLLAGGSSGLSSSELYDVYEQVLIASLECGRIENAMMYLNLLESRFGKKSVRVSHLRGLCLEAQGKIAEAKKLYEQVLKDLPTNDFCVKRLSAIYKSDGHYEEAIRVLEEDLVYTDEDDKQHTYFEVHRGDALPTYRELSNLHYLLGNIDKAIYYAEECLLFDNESYFSHVRLGELYYMKRDLPRCVIEYSQSLLFNSQQNNSRAAYGLWQVTSEMLRQHQSGARKIENEAELAQTQDLRTYAAETLRRMYAGTPMLSALDAYLQREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GWP0</accession>
    <name>A0A836GWP0_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_01632</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </evidence>
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        <source>
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    <sequence length="312" mass="34078" checksum="439CA3F0DF36F63A" modified="2021-09-29" version="1">MSANFSEMRGDQSASTPTLSLFELLDYGNGALELILMYWWAVVVGNLLLFAFAKHSLMRWELRQDRRRLECCNIRSCQRRRAVRKSKSAVSELSQCTNSEAGPNALGAHAMATSPAHKEPTEAEEATTPAGDSTSNSRKEPRLSLSEPKEDAASPKVAESTLKTALRSTRRGPQEATAAANEEESRPPLLLPLLPSATASDLSFSTSPPSAIQATSSATARLLKRISFMSHDLGQSNDDRIDCSRHSNSSDASSRLSSCCPRYSEDEQRLIDKKRQENVRAWMEAKRALELTESLAAGSGSIRSLSSVTLTD</sequence>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </evidence>
    <sequence length="153" mass="17655" checksum="0B13A34005153ED6" modified="2021-09-29" version="1">MLRSAEKHQGVKAMQMNRDRIKERIHEKHQQQRQQERESRLSGLREVDGDETSGNAWSAGILGDDVASHAEVVSSSTRAPESAQCYSPDRTLTVPSVQDWSDIGHEFGVNIDDVDVMEYLLALEEEIRQEQFFQFYDQTNGNEWEDYFRSLTC</sequence>
</entry>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="EMBL" id="JAFHLR010000014">
        <property type="protein sequence ID" value="KAG5483691.1"/>
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    <sequence length="109" mass="11709" checksum="8EFAEB449B2CC5B8" modified="2021-09-29" version="1">MAAPEAHAHQLLAARRVALLLKEALLVKDGLAGVSRTNFLEVVHLHDFVLRLPEELLLCEARLTALARGLRVKCRAENGITARLPTLQELVGLVPEEGVACAGASEESP</sequence>
</entry>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="15" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059587.1">
        <property type="nucleotide sequence ID" value="XM_067202937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GZU5"/>
    <dbReference type="SMR" id="A0A836GZU5"/>
    <dbReference type="GeneID" id="92356871"/>
    <dbReference type="KEGG" id="loi:92356871"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005745">
        <property type="term" value="C:m-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000352">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FTSH 7, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000018">
        <property type="entry name" value="Putative mitochondrial Mitochondrial ATP-dependent zinc metallopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050928">
        <property type="entry name" value="ATP-dep_Zn_Metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655:SF1">
        <property type="entry name" value="ATP-DEPENDENT ZINC METALLOPEPTIDASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="207"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="371"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="34"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG5467785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="789" mass="86323" checksum="F7AA0D966CD03AD5" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H047</accession>
    <name>A0A836H047_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_01037</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059752.1">
        <property type="nucleotide sequence ID" value="XM_067203102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H047"/>
    <dbReference type="GeneID" id="92357036"/>
    <dbReference type="KEGG" id="loi:92357036"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5467950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="397" mass="42940" checksum="EF2CEC1E13DF660B" modified="2021-09-29" version="1">MEAPRTLNNYLSLVDDFFRKTFRDDSCLFVALKSRQYSECILGVNMFAKDAAAVSADALLATAAEPASKRASPATPSVTETPRTHVSNFLSISPRMALHLDGSAEGKMKVAYEFEVPRVCRLQQALTLNNRGTVTVMGNVNELVEGLTAGVRASVNTIMPASEDVTFCRIHYQRGDKYSSLGYQRNGLGSSNLLLDCGVTFFNLLLGAGFERRQLSFLEQREGSPQLDVMYVGAGFTGVNWSIAAKMVRSNDAWSSARMAMLQRLSPTTAVACQYNFDLVEAVAKVSLGFTQGIQLRVPTLIRTKNAAVVTTSAFGSAPSSPSAPQVAEGALPMIPAWSTAVPLVVAAKAESDGNCSATLRGLFNNTIRWGLVARRNLLDRTSVVKYGVTLSMEYES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H077</accession>
    <name>A0A836H077_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ankyrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_01082</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059797.1">
        <property type="nucleotide sequence ID" value="XM_067203147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H077"/>
    <dbReference type="SMR" id="A0A836H077"/>
    <dbReference type="GeneID" id="92357081"/>
    <dbReference type="KEGG" id="loi:92357081"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF8">
        <property type="entry name" value="BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="33"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="68"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="102"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="135"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="293"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="305"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5467995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="341" mass="37101" checksum="42B43ECDCF814DA6" modified="2021-09-29" version="1">MSFKDVILRNDVSGVRSFFNAAGKNSVNAVSGEGYAPLYFACMKSSVSLQVIEELVRLGAAIDSRGTDGETPLYISVYNHRLDVTKYLISCKADVNAVNGPHRETALHVAARCGFADILSCLVSAGADLNVRNARQETPLYSAAKAGCHDTVYLLLEANANVSLPNEDGKTPLYIASEKEYKHVVILFKASRADLKHAKSLADSEWRLRPEPVMSSGEMLDKASSDQQFMAAVRRRSSVDAPAPDTKPMEVVRIKVPEPKVHMHNPLTGESYGPCRSLEEVGYDSPPPIPEELQNRPPARLSRIGGTSMVVGTGTEEGGREPIRVDLIGGEAVEYYVPLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836H088_9TRYP</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">LSCM4_05635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000016">
        <property type="protein sequence ID" value="KAG5482379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5482379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="759" mass="85351" checksum="17E9809E7C555270" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H0U0</accession>
    <name>A0A836H0U0_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067203030.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="92356964"/>
    <dbReference type="KEGG" id="loi:92356964"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="18"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="99"/>
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    </feature>
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        <location>
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            <end position="235"/>
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        <location>
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            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5467878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="363" mass="39101" checksum="617016F36BD895A6" modified="2021-09-29" version="1">MNILQKIFSPGSTAKKKTLLHGDLEVGDRQSRSTPKPSAPTRIKRKSTAESSADDLCGPLMQSVSMTVHSDPVPTSFKTNSSFANHARPTQGSASPKSLRLAGSLSNMSSHVDRHQQHSATLVSSVPRHSERSLFDKKQGSGSFAAGDTAVPGGSFAANGGTVNLWRLPWTQQKVIMCSNCHRPRQRDRSTYISRAHYTAQQVSCDNDMGDDISEANDDTSYSDSEDMGGPTSEAVSHCRCGITMDGDAPRDHHSSAEAAEEQPEVFVVETRNSNVARFPGTMGSDSDSDGEGAEGLRRSFKLSLVSSLTSSSLRRRAPHAPQALNADSRHSCTASVPRSVSHWLHEQQTSEAPAMLNLKAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836H1K6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Condensin complex subunit 1 C-terminal domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="9" type="ORF">LSCM4_07332</name>
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    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
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        <lineage>
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            <taxon>Trypanosomatida</taxon>
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            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000015">
        <property type="protein sequence ID" value="KAG5483114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064610.1">
        <property type="nucleotide sequence ID" value="XM_067209227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H1K6"/>
    <dbReference type="SMR" id="A0A836H1K6"/>
    <dbReference type="GeneID" id="92363161"/>
    <dbReference type="KEGG" id="loi:92363161"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000779">
        <property type="term" value="C:condensed chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010032">
        <property type="term" value="P:meiotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026971">
        <property type="entry name" value="CND1/NCAPD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032682">
        <property type="entry name" value="Cnd1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222">
        <property type="entry name" value="CONDENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222:SF2">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12717">
        <property type="entry name" value="Cnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensin complex subunit 1 C-terminal" evidence="8">
        <location>
            <begin position="1000"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1211"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1215"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1242"/>
            <end position="1256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5483114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1256" mass="140335" checksum="802584857EA481DA" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H2L2</accession>
    <name>A0A836H2L2_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02623</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Al-Salem W.S."/>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Jariyapan N."/>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <begin position="222"/>
            <end position="308"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="47"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="181"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
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        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
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            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5470306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
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</entry>
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        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    <dbReference type="KEGG" id="loi:92363178"/>
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    </dbReference>
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            <end position="99"/>
        </location>
    </feature>
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            <begin position="66"/>
            <end position="75"/>
        </location>
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        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5486421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="233" mass="25482" checksum="1DEB18891BE76095" modified="2021-09-29" version="1">MLRHRSLACLGRLRPTPLWWSAWAARRPMSTRQAERLRRSSTVPMAGGIVTSCAPPSGRVRCSRVASGSAQRATRSSPSSDGASSAFTTAQSAGSDGRARPLPGRFNRLTVQLGFLVAFYHYVLAESINLFLTYLLHSHRLGIGDTGCWLAAVGVPADRFLSVGPTVYGLHLSPRLLLNYLAVNACMYPSIPLQLRFCVATAPILRAPFQVMGRWLGMWKRATVPKAPRSTPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836H6A1_9TRYP</name>
    <protein>
        <submittedName>
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        </submittedName>
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        <dbReference type="NCBI Taxonomy" id="2249476"/>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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            <end position="28"/>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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        </location>
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            <end position="581"/>
        </location>
    </feature>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5471746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="608" mass="65104" checksum="640437622D891780" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H6B9</accession>
    <name>A0A836H6B9_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">LSCM4_04627</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Kinetoplastea</taxon>
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            <taxon>Trypanosomatida</taxon>
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            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000023">
        <property type="protein sequence ID" value="KAG5478395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063056.1">
        <property type="nucleotide sequence ID" value="XM_067206609.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="loi:92360543"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="117"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5478395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="191" mass="21324" checksum="6DD4035A2CC9B21C" modified="2021-09-29" version="1">MGSNSSRVGTALTPEAMDALYKEAYAAGTIDADMYHTSEREVMRQQDAMTGIGACMFSAWVAYVYGRTTGVQAAEDAASLRFDAQQRMLDKASKDLALKREENRSLITIRQEQDVVIAQQRDELKRAAQQRRAMQHSVNALRRRNASVQRQMQSLKSTLTAVQLQMYVSMAGAGLVVLTVVWATRSLRSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H6U5</accession>
    <name>A0A836H6U5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sel1 repeat family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Trypanosomatida</taxon>
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            <taxon>Leishmaniinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000007">
        <property type="protein sequence ID" value="KAG5486899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065693.1">
        <property type="nucleotide sequence ID" value="XM_067208288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H6U5"/>
    <dbReference type="SMR" id="A0A836H6U5"/>
    <dbReference type="GeneID" id="92362222"/>
    <dbReference type="KEGG" id="loi:92362222"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050767">
        <property type="entry name" value="Sel1_AlgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102:SF160">
        <property type="entry name" value="ERAD-ASSOCIATED E3 UBIQUITIN-PROTEIN LIGASE COMPONENT HRD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102">
        <property type="entry name" value="SEL-1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5486899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="432" mass="44906" checksum="9EB55953505ED35A" modified="2021-09-29" version="1">MPPPRDVNFGIYDKRRPATSPTRRGGRGRRASHLQPLPGDMMTAASETGRSFKRLRAAPLTSTTSSSAPSCSPFPPSSAQCPAGTFGGAQAASSIPRRGGAAPPTTTRSSTGSVAAASAAALLCENEQHRGCPPPSCACSASSLSVVEDRVRCLVHPVGAASLLPAPLQGVLANVLRILQQERAQLKGQRPCRRHARPIGTGADADVTECIVHAAQAPSLVAAADIFSAFVSAHPTEGPALLSSPVVLVGAALAELVILDGVASRVIPAPQLLSFLDAAIAVGHLGAMHTVAVCLREGTAGLQRDAASSETWMRCAAAAGYLPAMQELGETYERGAPAPSKLAVEGGEGASDWGEAMRWYRRAAEAGYPPSQLNLGKLLLMAAEHAEREGIASAPQVAYLFTEAKRWLQACAATGLEEAVRLRKRVETQVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H7R0</accession>
    <name>A0A836H7R0_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060745.1">
        <property type="nucleotide sequence ID" value="XM_067205193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H7R0"/>
    <dbReference type="GeneID" id="92359127"/>
    <dbReference type="KEGG" id="loi:92359127"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5471628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="233" mass="26357" checksum="70A705F3F74D2AD3" modified="2021-09-29" version="1">MLAQYGGHDVPFARIRAVHPGDDVFPEETNIGTKRAARSPLCNEIQKHGGNDESARLLQTKRHARTLIAEVQVCVDLPTFLDELRFPLHPARLLLLGSSAVLHYTGVEDPASHCSPAVLRHWHSRTTRMQVSISNSRWYIKLFLFSHSSVVRQSAPPWHKGRQRPAQHVQAAPRHDHKARIEVPLRVVIAQALCRGVQLRLRMTAHALLNVQTNNASQDKRNQRRLRGRPRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H7Z3</accession>
    <name>A0A836H7Z3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_03301</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060865.1">
        <property type="nucleotide sequence ID" value="XM_067205313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H7Z3"/>
    <dbReference type="SMR" id="A0A836H7Z3"/>
    <dbReference type="GeneID" id="92359247"/>
    <dbReference type="KEGG" id="loi:92359247"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031397">
        <property type="term" value="P:negative regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030178">
        <property type="term" value="P:negative regulation of Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46472">
        <property type="entry name" value="NUCLEOREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46472:SF1">
        <property type="entry name" value="NUCLEOREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13905">
        <property type="entry name" value="Thioredoxin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="12"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5471748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="186" mass="21436" checksum="DDDF1F77D412E614" modified="2021-09-29" version="1">MEPNFFNNSEIMLLCKDASAVRAIDILKDVEYVLVYFSAHWCPPCRAFTPLLKKFYEAHHVKKKFEVVFMSMDKSEKEMMSYFGESHGDYYCLPYADAKSMVRVWGHTYRFETIPTLLVFENANPRKLIARCGRDMVVQDPSAEEFPWHEADAMHPPASRTANHALKISIALGILFLLYALISRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H841</accession>
    <name>A0A836H841_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061177.1">
        <property type="nucleotide sequence ID" value="XM_067204140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H841"/>
    <dbReference type="SMR" id="A0A836H841"/>
    <dbReference type="GeneID" id="92358074"/>
    <dbReference type="KEGG" id="loi:92358074"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5472781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="551" mass="58133" checksum="436684F3968F0375" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HB29</accession>
    <name>A0A836HB29_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">60S ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_03690</name>
        <name evidence="6" type="ORF">LSCM4_03691</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">LSCM4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061623.1">
        <property type="nucleotide sequence ID" value="XM_067205686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HB29"/>
    <dbReference type="SMR" id="A0A836HB29"/>
    <dbReference type="GeneID" id="92359620"/>
    <dbReference type="KEGG" id="loi:92359620"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00499">
        <property type="entry name" value="Ribosomal_eL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001380">
        <property type="entry name" value="Ribosomal_eL13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01294">
        <property type="entry name" value="Ribosomal_L13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5473620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5473621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="24869" checksum="6A5747D5A3AD317B" modified="2021-09-29" version="1">MPKGNNAIPHVHQKKHWNPCSSQKGNVKVFLNQPAQKHRRRRLRLVKAKKVFPRPLKALRPQVNCPTVRHNMKRRLGRGFSPAELKAVGLNPHYAATIGIRVDSRRKNKSEEGMNVNVQRLKTYMSKLVLFPMNHKKVQKGEASEEEVKAATQDRSRFGDAAVGPVVFPAAEAPRAVSAEEKTKNVYAFLKKNHSAVRFFGARKARAERREAAKEEKGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HCV5</accession>
    <name>A0A836HCV5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dynein light intermediate chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_04967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000014">
        <property type="protein sequence ID" value="KAG5483812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064751.1">
        <property type="nucleotide sequence ID" value="XM_067206942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HCV5"/>
    <dbReference type="GeneID" id="92360876"/>
    <dbReference type="KEGG" id="loi:92360876"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5483812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="621" mass="66266" checksum="AC76F3D7B54DC5AF" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HF57</accession>
    <name>A0A836HF57_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">asparaginase</fullName>
            <ecNumber evidence="2">3.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_07210</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-asparagine + H2O = L-aspartate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:21016"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="EC" id="3.5.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparaginase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.1" evidence="2"/>
    <dbReference type="EMBL" id="JAFHLR010000015">
        <property type="protein sequence ID" value="KAG5483000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064496.1">
        <property type="nucleotide sequence ID" value="XM_067209113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HF57"/>
    <dbReference type="SMR" id="A0A836HF57"/>
    <dbReference type="GeneID" id="92363047"/>
    <dbReference type="KEGG" id="loi:92363047"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009066">
        <property type="term" value="P:aspartate family amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08963">
        <property type="entry name" value="L-asparaginase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1170:FF:000001">
        <property type="entry name" value="L-asparaginase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1170">
        <property type="entry name" value="L-asparaginase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036152">
        <property type="entry name" value="Asp/glu_Ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006034">
        <property type="entry name" value="Asparaginase/glutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027475">
        <property type="entry name" value="Asparaginase/glutaminase_AS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027473">
        <property type="entry name" value="L-asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041725">
        <property type="entry name" value="L-asparaginase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027474">
        <property type="entry name" value="L-asparaginase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037152">
        <property type="entry name" value="L-asparaginase_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707:SF28">
        <property type="entry name" value="60 KDA LYSOPHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00710">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001220">
        <property type="entry name" value="L-ASNase_gatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500176">
        <property type="entry name" value="L_ASNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00139">
        <property type="entry name" value="ASNGLNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00057">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00870">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53774">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00917">
        <property type="entry name" value="ASN_GLN_ASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51732">
        <property type="entry name" value="ASN_GLN_ASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="L-asparaginase N-terminal" evidence="7">
        <location>
            <begin position="53"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="active site" description="O-isoaspartyl threonine intermediate" evidence="4">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="141"/>
            <end position="142"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00049366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001220-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001220-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5483000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="422" mass="45448" checksum="D952079B49C98861" modified="2021-09-29" version="1">MASPGHTTTLPSPLTPSLVSAMEAAAAAAISGATSPSSLVQSSLPRSAVVTRRILVLYLGGTIGMKKNAEGALEPVAGYLTEQMREMRELRESAEIAPFDIIEYDELLDSSDIGASDYCRIAADLQTHYDEYDGFLIAHGTDTMHYTASALSFLLCNLDKPVIMTGAMVPLAEPYNDARRNLVISMMIASNPRICEVCIFFNDSLFRGNRCNKVYHTYGAFCSLNYPPLGVMEATHFVLREEHLLPQPTGAMKIMSDMRGRLGCYPIDPEADVDTLVALLERKRPRPSAGAFPVASGSLADDSGDTQQPLLDAVLLSLNGVGSVEGAVAQQLRQIVAAARKYDIVVCAVARDISGTLNPSEVHRLHTIAPDIVYLNDMCISAAEVKLMYLFGKGLSPAKVAAAMPQNLRGEITPLLPAQSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HF92</accession>
    <name>A0A836HF92_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sm protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LSCM4_04277</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the snRNP SmB/SmN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062201.1">
        <property type="nucleotide sequence ID" value="XM_067206264.1"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A836HF92"/>
    <dbReference type="GeneID" id="92360198"/>
    <dbReference type="KEGG" id="loi:92360198"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070990">
        <property type="term" value="F:snRNP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01717">
        <property type="entry name" value="Sm_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000049">
        <property type="entry name" value="Small nuclear ribonucleoprotein-associated protein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050914">
        <property type="entry name" value="snRNP_SmB/NAA38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701:SF0">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="82"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG5475693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="111" mass="12009" checksum="E88859E736BA3C40" modified="2021-09-29" version="1">MGKYTMLHNINKVLCVVLDDGRSVTGKLLVFDKHMNVVLADAVEERPQSKRMVEEGVSSKRQLGLILLRGEHVVSVTVMKSSENGGSGAAANFSSAPKSAKATAVKRKRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HFY4</accession>
    <name>A0A836HFY4_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062286.1">
        <property type="nucleotide sequence ID" value="XM_067206983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HFY4"/>
    <dbReference type="SMR" id="A0A836HFY4"/>
    <dbReference type="GeneID" id="92360917"/>
    <dbReference type="KEGG" id="loi:92360917"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5476053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="674" mass="75499" checksum="188C881C4BDD8AB2" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HG43</accession>
    <name>A0A836HG43_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_04424</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062617.1">
        <property type="nucleotide sequence ID" value="XM_067206408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HG43"/>
    <dbReference type="GeneID" id="92360342"/>
    <dbReference type="KEGG" id="loi:92360342"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5477206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="349" mass="37303" checksum="8E74DEAC4626BBCD" modified="2021-09-29" version="1">MNELAEPSFVLRHIRRCGADGQNQPSQQANTSAVATTVTHGSSYTTEVLLKVGVRASPSLADSSSCASSQETVCYMCPAYILQAGCPTLRELLADGFEGGPSGIRGVDDEAGAGSAAAVARVSSPPVAIPLPFLDGEVFEVVAVYLEHFYAFDLTITTGITSTAAHPSVASLATSSARAPSSLRRPLNFQDLYALSTWEHHYVLSQLLGLERSQIDSLRLVECGVWVDLLGGAAAEPPPKGETQQQHQVNVAEGTVFSQQRADCFSLANRRRMWSRLCQVLEAVLRLGMTTLRLLCAAVAADMLVDLDEAGLARLTQLSGDGSGIKSIPPLTAQARAQLLHRFPWLKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HH52</accession>
    <name>A0A836HH52_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_06830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000009">
        <property type="protein sequence ID" value="KAG5486122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065453.1">
        <property type="nucleotide sequence ID" value="XM_067208742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HH52"/>
    <dbReference type="SMR" id="A0A836HH52"/>
    <dbReference type="GeneID" id="92362676"/>
    <dbReference type="KEGG" id="loi:92362676"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="236"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5486122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="280" mass="29757" checksum="73F0AAF3983B5643" modified="2021-09-29" version="1">MSASPRLRASSPMMMSATGSQHFPARSPSALAHTNASSMAVLEKRAPANPLLATPTSHLSQAGWQCAAPCAPTDTPSGEPAPDVVAVLRHALVRDLVRENEGMLMELAGLRERERQWCAAQVRLVALEESAARAALKTVEAIERGMSATRAHAFLAAHVQRLEQQLSDEAEEAAQLRGFAELAQAQLVTSPRPLTQGATPEGKQFASPPVKARRGCNVVNADGDSQRTSLEEITNARGSVKRLRSVESSDGGGTPLGHARRTGSGRKSPGALTKMRKTIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HJD1</accession>
    <name>A0A836HJD1_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_07781</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000006">
        <property type="protein sequence ID" value="KAG5487292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065789.1">
        <property type="nucleotide sequence ID" value="XM_067209659.1"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A836HJD1"/>
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    <dbReference type="KEGG" id="loi:92363593"/>
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    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
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    </dbReference>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
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            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="363"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="403"/>
            <end position="423"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5487292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="661" mass="71171" checksum="474F0071E314BC30" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HKB4</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">LSCM4_06643</name>
    </gene>
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        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000010">
        <property type="protein sequence ID" value="KAG5485685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065269.1">
        <property type="nucleotide sequence ID" value="XM_067208558.1"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A836HKB4"/>
    <dbReference type="GeneID" id="92362492"/>
    <dbReference type="KEGG" id="loi:92362492"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035253">
        <property type="term" value="C:ciliary rootlet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097542">
        <property type="term" value="C:ciliary tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036158">
        <property type="term" value="P:outer dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="ODAD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46518">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46518:SF1">
        <property type="entry name" value="OUTER DYNEIN ARM-DOCKING COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="412"/>
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        <location>
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            <end position="625"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="789"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="857"/>
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            <begin position="11"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="385"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="748"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="766"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="820"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="848"/>
            <end position="857"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5485685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="857" mass="92397" checksum="6439EF725656BC19" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HL14</accession>
    <name>A0A836HL14_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BolA-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_05929</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the BolA/IbaG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063632.1">
        <property type="nucleotide sequence ID" value="XM_067207859.1"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A836HL14"/>
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    <dbReference type="KEGG" id="loi:92361793"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.90">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050961">
        <property type="entry name" value="BolA/IbaG_stress_morph_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46229">
        <property type="entry name" value="BOLA TRANSCRIPTION REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46229:SF2">
        <property type="entry name" value="BOLA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003113">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5479921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="78" mass="8513" checksum="C87DCF6F1C5295C6" modified="2021-09-29" version="1">MSSIRDIVVARVQGAFQPTELEVTEISADEAKYSVRIVSAAFAGVPLIQRHRMVNNLFSEEMRSGTIHALSISAQPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HMV6</accession>
    <name>A0A836HMV6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Guanine nucleotide-binding protein subunit beta-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_05716</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063421.1">
        <property type="nucleotide sequence ID" value="XM_067207648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HMV6"/>
    <dbReference type="SMR" id="A0A836HMV6"/>
    <dbReference type="GeneID" id="92361582"/>
    <dbReference type="KEGG" id="loi:92361582"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040066">
        <property type="entry name" value="WDR31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19869">
        <property type="entry name" value="SPERMATID WD-REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19869:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="135"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="177"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5479710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="423" mass="46138" checksum="7DD162B4D3984F46" modified="2021-09-29" version="1">MGNTCAKTGEVVDNRKNGRYHEYSKRYRVKQHTKLEDVPSPPANDETVAGPAATIVVKSIEALQHMLKPAVSVVASELRHEAFRQFTSVFARGSAVLAVASCAQARQPRHVLAAGEDRSVALLNYETGHVMQRWMHAHQNDINCITTPTSSGLFATASRDKTVKLWDFTSNGSLAELRGHTLNVTSIDTSVDGNLLVSGSKDNTVRLWDVERAEELFCGDVKLNIVHFVRFMPAMNCVAQGGEDLAVRLWDVRTKGAHSDLSLSKTIEGMNYYPVCCETIPENPHMLLTGHNGVNGCGSYVAQWDVRTGKRMALYKGHGATVSGVRMVASSVYGKGSFFTSSDDGTFGVWNLEDGEACGEVQLRAEHCFCLPEGRVTTFEAEDNGDTVMALDDGCLVVLRPAVSGDFVIPSLRLRYVGVLTAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HPD9</accession>
    <name>A0A836HPD9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycosyl hydrolase family 32 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_07587</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000004">
        <property type="protein sequence ID" value="KAG5487905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066102.1">
        <property type="nucleotide sequence ID" value="XM_067209470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HPD9"/>
    <dbReference type="SMR" id="A0A836HPD9"/>
    <dbReference type="GeneID" id="92363404"/>
    <dbReference type="KEGG" id="loi:92363404"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050551">
        <property type="entry name" value="Fructan_Metab_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018053">
        <property type="entry name" value="Glyco_hydro_32_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31953">
        <property type="entry name" value="BETA-FRUCTOFURANOSIDASE, INSOLUBLE ISOENZYME CWINV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00609">
        <property type="entry name" value="GLYCOSYL_HYDROL_F32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032458364" description="Glycosyl hydrolase family 32 N-terminal domain-containing protein" evidence="5">
        <location>
            <begin position="29"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 N-terminal" evidence="6">
        <location>
            <begin position="39"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="190"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5487905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="267" mass="30244" checksum="E4A4FEE9CA87EC03" modified="2021-09-29" version="1">MIAPSFPSRRLILLLVAVAMMAAAVTVAMDGVPYEPIYHIRPPKNWVNDPNGPYRDPVTGKVHLYMQYNPNGPLWGDIAWYHVTSEDYVKWTRPESPVAVWADRWYDKWGAYSGTMMNNNYSEPVMVYTCTEPENIQRQCIANPPKSDLHGKRTLDTLVKSPLNVIMSEDMIPGIVATENFRDPTEWWQDPASGRQQCAGTPLHSTTPPLTCSRTDGHAHRHTEPVATGATARRGEAPRQSRMNLRRYLKQSFICTDQVEGLTSWNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HPJ3</accession>
    <name>A0A836HPJ3_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_08219</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000003">
        <property type="protein sequence ID" value="KAG5487995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066122.1">
        <property type="nucleotide sequence ID" value="XM_067210089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HPJ3"/>
    <dbReference type="SMR" id="A0A836HPJ3"/>
    <dbReference type="GeneID" id="92364023"/>
    <dbReference type="KEGG" id="loi:92364023"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5487995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="313" mass="35578" checksum="98F0D78D05D3E1BC" modified="2021-09-29" version="1">MSSPAMLRTSGALLDKSVFAAKRRVIVPIQPTPGYPAHFIKASFTTDPLKEKQKARFSSGGDAMREVQDIPKRLEGQRSRAELASRGDGDFEALIEFIKGASYDQLISGRRFRKIYEKLSENDDMFVWLCHTAMAVLNPGDMRSRLIYNHLKALAEAVASGEMTQRTAFRFFESAVRSPAYREIAARQLETGAATRLAGVAAAADVMREMGLTRRPMSSYFELYQRIVERSEAMTPWGFPPLFQFEERLALEPRLKFFSRAGQQQLERRRRGSIFSPHTILQGRRIFWIPPTWNRAGRFIGPHINLYPGLTPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HPM2</accession>
    <name>A0A836HPM2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_06184</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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</entry>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
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                <person name="Gatherer D."/>
            </authorList>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="term" value="F:malonyl-CoA decarboxylase activity"/>
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        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.150">
        <property type="entry name" value="Malonyl-CoA decarboxylase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038917">
        <property type="entry name" value="Malonyl_CoA_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007956">
        <property type="entry name" value="Malonyl_CoA_deC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042303">
        <property type="entry name" value="Malonyl_CoA_deC_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28641">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28641:SF1">
        <property type="entry name" value="MALONYL-COA DECARBOXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05292">
        <property type="entry name" value="MCD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malonyl-CoA decarboxylase C-terminal" evidence="1">
        <location>
            <begin position="377"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="Malonyl-CoA decarboxylase C-terminal" evidence="1">
        <location>
            <begin position="672"/>
            <end position="759"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5486868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="788" mass="85584" checksum="6A7900B0D2EAA0EF" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836K691</accession>
    <name>A0A836K691_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LSCM4_00054</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Probably involved in the control of the cell cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058245.1">
        <property type="nucleotide sequence ID" value="XM_067202144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836K691"/>
    <dbReference type="SMR" id="A0A836K691"/>
    <dbReference type="GeneID" id="92356078"/>
    <dbReference type="KEGG" id="loi:92356078"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010389">
        <property type="term" value="P:regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07829">
        <property type="entry name" value="STKc_CDK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000574">
        <property type="entry name" value="Cell division related protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000375">
        <property type="entry name" value="Cell division related protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF254">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="23"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00059987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00064639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG5464614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="311" mass="35584" checksum="993459F1E413A405" modified="2021-09-29" version="1">MSSFGRVTSRSGDAGSRDSLDRYNRLDVLGEGTYGVVYRAVDKVTGQYVALKKVRLDRTEEGIPQTALREVSILQEFDHPNIVNLLDVICSDGKLYLVFEYVEADLKKAIEKQEGGYSGMDLKRLIYQLLDGLYFCHRHRIIHRDLKPANILLTSGNVLKLADFGLARAFQVPMHTYTHEVVTLWYRAPEILLGEKHYTPAVDMWSVGCIFAELARRKVLFRGDSEIGQLFEIFQLLGTPVDAEGSWPGVSRLPDYRDVFPKWTAKRLGQVLPELHPDAIDLISKMLKYDPRERISAKEALQHPWFSDLRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836K6C7</accession>
    <name>A0A836K6C7_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_00175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058365.1">
        <property type="nucleotide sequence ID" value="XM_067202264.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92356198"/>
    <dbReference type="KEGG" id="loi:92356198"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5464734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1838" mass="195266" checksum="40DBE00C7704A05A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KAB6</accession>
    <name>A0A836KAB6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">L-dopachrome isomerase</fullName>
            <ecNumber evidence="9">5.3.2.1</ecNumber>
            <ecNumber evidence="8">5.3.3.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">L-dopachrome tautomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Phenylpyruvate tautomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LSCM4_02495</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-phenylpyruvate = enol-phenylpyruvate</text>
            <dbReference type="Rhea" id="RHEA:17097"/>
            <dbReference type="ChEBI" id="CHEBI:16815"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="EC" id="5.3.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-dopachrome = 5,6-dihydroxyindole-2-carboxylate</text>
            <dbReference type="Rhea" id="RHEA:13041"/>
            <dbReference type="ChEBI" id="CHEBI:16875"/>
            <dbReference type="ChEBI" id="CHEBI:57509"/>
            <dbReference type="EC" id="5.3.3.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MIF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.2.1" evidence="9"/>
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        <property type="nucleotide sequence ID" value="XM_067204524.1"/>
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        <property type="term" value="F:dopachrome isomerase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="F:phenylpyruvate tautomerase activity"/>
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        </source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00036735"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00036823"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038932"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00041631"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00041912"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00042730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG5469099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="113" mass="12710" checksum="F9522D33123CAC56" modified="2021-09-29" version="1">MPFLQTITSVPLDVEKRASLSKAYCTLCREELGKPEDFVMTAFSDNVPIVFKGSEDPAAYVRVEILGNYTSSQPKMMTPRMTEAIKKECGIPADRIYVLYYSTQHCGWNGANF</sequence>
</entry>
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            <fullName evidence="6">Alpha-type protein kinase domain-containing protein</fullName>
        </recommendedName>
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        <name type="scientific">Leishmania orientalis</name>
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    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067202567.1"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A836KAI1"/>
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    <dbReference type="KEGG" id="loi:92356501"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031037">
        <property type="term" value="P:myosin II filament disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903013">
        <property type="term" value="P:response to differentiation-inducing factor 1"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="MHCK/EF2 kinase"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="a-kinase_dom"/>
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        <property type="entry name" value="Alpha-type_PK"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45992:SF2">
        <property type="entry name" value="EUKARYOTIC ELONGATION FACTOR 2 KINASE"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Alpha_kinase"/>
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        <property type="entry name" value="ALPHA_KINASE"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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            <end position="398"/>
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    </feature>
    <feature type="domain" description="Alpha-type protein kinase" evidence="6">
        <location>
            <begin position="489"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-type protein kinase" evidence="6">
        <location>
            <begin position="864"/>
            <end position="1111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5465037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1142" mass="127145" checksum="D4F1E613D746391C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KCU2</accession>
    <name>A0A836KCU2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_02437</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Kinetoplastea</taxon>
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            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060018.1">
        <property type="nucleotide sequence ID" value="XM_067204466.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="92358400"/>
    <dbReference type="KEGG" id="loi:92358400"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.300.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125">
        <property type="entry name" value="LP07818P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125:SF10">
        <property type="entry name" value="OS12G0136300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="68"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="770"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="276"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5469041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="789" mass="85535" checksum="1447BB8F73272A82" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KCY2</accession>
    <name>A0A836KCY2_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_00896</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059614.1">
        <property type="nucleotide sequence ID" value="XM_067202964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KCY2"/>
    <dbReference type="GeneID" id="92356898"/>
    <dbReference type="KEGG" id="loi:92356898"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5467812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="355" mass="37818" checksum="6EEECDE79B2ED0AD" modified="2021-09-29" version="1">MVCYKTDLREALMWGFDAYAEGLSTTPNTDGAPLADTTAKEGAAAPPRCLCKQNQNRDVFDAQGNLLNTSEAHSATTWRTHHAFSGRCALVNEATAAGGAAAHCFTAPDWAEQAWTAYQSWSVAFRLRSITTDEPHILLSVAPAYFPSLATVTGGTREADAATLASLPGAPSAEEEVIYNKRMLETPLIWEEPYALSVECTPNGVFLWSDHWGIFGKRVADHCMEVRRGAARQSGMAKLPSPGPPLASAAADEKPAPTIYDAALRLRWSATGTGNQSSTDGVPASAATPTLSVELKLASADEAGRTAATTCVEGVGEDLWQHLVNLPLPLDEVARKAAFRPYVTLMEGGDAVELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KE56</accession>
    <name>A0A836KE56_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_02295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061365.1">
        <property type="nucleotide sequence ID" value="XM_067204328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KE56"/>
    <dbReference type="SMR" id="A0A836KE56"/>
    <dbReference type="GeneID" id="92358262"/>
    <dbReference type="KEGG" id="loi:92358262"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF95">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5472969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="26732" checksum="7EFDCA3A71458169" modified="2021-09-29" version="1">MSLRARALKRPAQTRLAEIVSAYVQHLMSLQASRGDVTSLDRPVIPPPNNQYPSHDFFCATHAPPISVEKYAVRLVTYMQCSPEVFVFALAYLRRLVFGGFPVHIRSIHRLLLTAVLVALKCRDDAYYQMSFYAEIGGVTPKDLCIMEIRFLSDLIHFEGEVSLTDYHTVMEDITRVTQRRVMEKSVSDDSDLCNQCELSAGASTSSTPGDLVSPHDKRDVLTRSWTSECELFWDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KG23</accession>
    <name>A0A836KG23_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ama1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_02069</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061142.1">
        <property type="nucleotide sequence ID" value="XM_067204105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KG23"/>
    <dbReference type="SMR" id="A0A836KG23"/>
    <dbReference type="GeneID" id="92358039"/>
    <dbReference type="KEGG" id="loi:92358039"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006461">
        <property type="entry name" value="PLAC_motif_containing"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01571">
        <property type="entry name" value="A_thal_Cys_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15907">
        <property type="entry name" value="DUF614 FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04749">
        <property type="entry name" value="PLAC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5472746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="182" mass="20041" checksum="604A819A10BB1FE4" modified="2021-09-29" version="1">MYTQPPDADAGNGANGYKPPYGQQPMLGKGPNPKNADSAFAAASNPAQQRRSGLWHYSLCVCCKDTDSCCESCCCLPCQVSRQCNMLTHNIPEIDYPYCLLMTFCDLSLFFLSVTCVFVSETRRLARERYGISGSTCDDCCISYWCRCCSTQQVLLEMTAMSDFPGATCYDISPQPAGNEMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KGQ1</accession>
    <name>A0A836KGQ1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_03534</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061469.1">
        <property type="nucleotide sequence ID" value="XM_067205532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KGQ1"/>
    <dbReference type="SMR" id="A0A836KGQ1"/>
    <dbReference type="GeneID" id="92359466"/>
    <dbReference type="KEGG" id="loi:92359466"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000007">
        <property type="entry name" value="Sulfite oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359:SF146">
        <property type="entry name" value="B5, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="5">
        <location>
            <begin position="15"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5473466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="168" mass="18814" checksum="CD193FF980856C63" modified="2021-09-29" version="1">MLSGLLVLSGLKKRWPVLSEEEIRMHNTRRSLWIVSGNSVYDVTGILGSHPGGEAAILRRGGGSKNCEADYRLHSRYARRQWDDRKVGEITAEVALRLFPPRTVTHEANTRSVTAYPEGSSPVGITRAHINSGEESHTRTVDTYASTTTTPDQQYCRYEFGPCPQRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KH63</accession>
    <name>A0A836KH63_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cysteine protease</fullName>
            <ecNumber evidence="11">3.4.22.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LSCM4_01947</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine</text>
            <dbReference type="Rhea" id="RHEA:67548"/>
            <dbReference type="Rhea" id="RHEA-COMP:17323"/>
            <dbReference type="Rhea" id="RHEA-COMP:17324"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:172940"/>
            <dbReference type="ChEBI" id="CHEBI:172941"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:67549"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the peptidase C54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.-" evidence="11"/>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061023.1">
        <property type="nucleotide sequence ID" value="XM_067203986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KH63"/>
    <dbReference type="SMR" id="A0A836KH63"/>
    <dbReference type="GeneID" id="92357920"/>
    <dbReference type="KEGG" id="loi:92357920"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019786">
        <property type="term" value="F:protein-phosphatidylethanolamide deconjugating activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035973">
        <property type="term" value="P:aggrephagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005078">
        <property type="entry name" value="Peptidase_C54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046792">
        <property type="entry name" value="Peptidase_C54_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624:SF49">
        <property type="entry name" value="CYSTEINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624">
        <property type="entry name" value="CYSTEINE PROTEASE ATG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03416">
        <property type="entry name" value="Peptidase_C54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0645">Protease</keyword>
    <keyword evidence="8 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase C54 catalytic" evidence="13">
        <location>
            <begin position="44"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="333"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="351"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="367"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="380"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG5472627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="394" mass="43867" checksum="761F438AB6240733" modified="2021-09-29" version="1">MLRYVQDLWSAFFPMEAVFPLQVVGRSGAAVESREELEKALSDTFLIFTYRDGFEAIPAVTRLIETDQGWGCLLRTSQMLLAHFLWVHGRPADRKLSLFFDHSAETAPFSIHNMIRSVWNRRAFKAEYWSPSQGCEAIKRTMQDAMKTEQLQTRVTVVTSTNGCVYADEVQHTFKEGAEVVLVLASVRVSAAAQLTQESYLQIEKLMEQPQCLGVVGGVPGRSYYFFAHNQTQLFYLDPHQRTTAALLSEGPSSTVSVTPSVADVRCVHWSRVDTSLFLAFAVTTRDEWAALEVHLSNRFLHVESQLTRRDCDQLVRPRQACADGTFASPLRAGGSGGMGGVPSSTAAPLAHRRTLRVSRERRKNGEAGTATAATSEGNACEDELDTDSWEYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KH76</accession>
    <name>A0A836KH76_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GrpE protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_01994</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GrpE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061068.1">
        <property type="nucleotide sequence ID" value="XM_067204031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KH76"/>
    <dbReference type="SMR" id="A0A836KH76"/>
    <dbReference type="GeneID" id="92357965"/>
    <dbReference type="KEGG" id="loi:92357965"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.20.20:FF:000018">
        <property type="entry name" value="GrpE protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="GRPE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237:SF23">
        <property type="entry name" value="GRPE PROTEIN HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="Coiled-coil domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01071">
        <property type="entry name" value="GRPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5472672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="218" mass="23850" checksum="FDD5A2165D106294" modified="2021-09-29" version="1">MRALALRTRLAARAPAVVFASQRWCSTEAKPEKPAEEKEVPKAETEEVVSAAAVKQLEKELDASKATIEELKKEILYRAADAENARRIGREDVEKAKLYGISSFGKDMLEVADTLEKGVEAFSAFSEADLNENKMLGSIFTGVKLSHKVLLKNLAKHGIEKMGVTVGTKFDPNLHDALVSTSVTEKSPVDTISNVLKDGYTLRSRVLRAAQVSVSQHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KIJ1</accession>
    <name>A0A836KIJ1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">methylmalonyl-CoA mutase</fullName>
            <ecNumber evidence="3">5.4.99.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_04103</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methylmalonyl-CoA mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.2" evidence="3"/>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062029.1">
        <property type="nucleotide sequence ID" value="XM_067206092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KIJ1"/>
    <dbReference type="SMR" id="A0A836KIJ1"/>
    <dbReference type="GeneID" id="92360026"/>
    <dbReference type="KEGG" id="loi:92360026"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004494">
        <property type="term" value="F:methylmalonyl-CoA mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019678">
        <property type="term" value="P:propionate metabolic process, methylmalonyl pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02071">
        <property type="entry name" value="MM_CoA_mut_B12_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03679">
        <property type="entry name" value="MM_CoA_mutase_alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.280:FF:000002">
        <property type="entry name" value="Methylmalonyl-CoA mutase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.240:FF:000001">
        <property type="entry name" value="Probable methylmalonyl-coa mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.280">
        <property type="entry name" value="Cobalamin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.240">
        <property type="entry name" value="Methylmalonyl-CoA mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006159">
        <property type="entry name" value="Acid_CoA_mut_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006099">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006098">
        <property type="entry name" value="MMCoA_mutase_a_cat"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00640">
        <property type="entry name" value="acid_CoA_mut_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00641">
        <property type="entry name" value="acid_CoA_mut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006944">
        <property type="entry name" value="PRK09426.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48101:SF4">
        <property type="entry name" value="METHYLMALONYL-COA MUTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48101">
        <property type="entry name" value="METHYLMALONYL-COA MUTASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01642">
        <property type="entry name" value="MM_CoA_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="Cobalamin (vitamin B12)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="Cobalamin (vitamin B12)-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="7" id="KW-0170">Cobalt</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="8">
        <location>
            <begin position="593"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5475521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="723" mass="79796" checksum="8CDF0E8B5FA014CB" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KIL8</accession>
    <name>A0A836KIL8_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_04462</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062655.1">
        <property type="nucleotide sequence ID" value="XM_067206446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KIL8"/>
    <dbReference type="GeneID" id="92360380"/>
    <dbReference type="KEGG" id="loi:92360380"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5477244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="73" mass="7738" checksum="E4F061F6A6CB8E30" modified="2021-09-29" version="1">MVYRYIYLTVAGRVMVVAPGGCHKSVPRTLGVPSRLCLRSCCRVRVAFQPSAAAICGAAGMLNGDAVVLTVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KMU2</accession>
    <name>A0A836KMU2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">SAM-dependent MTase RsmB/NOP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LSCM4_03110</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">LSCM4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060680.1">
        <property type="nucleotide sequence ID" value="XM_067205128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KMU2"/>
    <dbReference type="SMR" id="A0A836KMU2"/>
    <dbReference type="GeneID" id="92359062"/>
    <dbReference type="KEGG" id="loi:92359062"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009383">
        <property type="term" value="F:rRNA (cytosine-C5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000609">
        <property type="entry name" value="Putative nucleolar protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1170:FF:000001">
        <property type="entry name" value="Ribosomal RNA methyltransferase Nop2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1170">
        <property type="entry name" value="Sun protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011023">
        <property type="entry name" value="Nop2p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023273">
        <property type="entry name" value="RCMT_NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054728">
        <property type="entry name" value="RsmB-like_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018314">
        <property type="entry name" value="RsmB/NOL1/NOP2-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00446">
        <property type="entry name" value="nop2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807:SF30">
        <property type="entry name" value="28S RRNA (CYTOSINE(4447)-C(5))-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22458">
        <property type="entry name" value="RsmF-B_ferredox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02012">
        <property type="entry name" value="RCMTNOP2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01153">
        <property type="entry name" value="NOL1_NOP2_SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 9" id="KW-0489">Methyltransferase</keyword>
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                <person name="Bates M.D."/>
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</entry>
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                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5478070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="387" mass="42416" checksum="66A02F1E00715EC9" modified="2021-09-29" version="1">MKPFAPFVCQLPSRRILRVRGTDAHEFLQGIFTNDLRNLHPTGSMYGCFLHFTGRVLCDALLYQCKQVYEGQASILVDVHERSSAELLSHLMEMKMRKKVTIDDVGRELVVLAALEETFAAPPTGGHAQQKSSLGSDNDARASSITSSSPATLGERHTECFADPRNSALFPRLPQPSSELASDSEEAVAAATAPISPSTPPSWRLRRCVVPATWAPPPSSADPYTTLLYRRGIGEGPDVFKSNKSLPFEGNLDFLRGVSFHKGCYVGQELTHRTHVMLVTRKRTVPLHFGPASVDSPVLRPISENGNVVTTRPVEVGEPLMSAAKEKIGEVTGVCGRVGVGLFRLRYVDSATLTVPGLQLEDGTPVQTHLPDWWPRKEVKKLLKNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KQD1</accession>
    <name>A0A836KQD1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinase</fullName>
            <ecNumber evidence="4">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_04861</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="4"/>
    <dbReference type="EMBL" id="JAFHLR010000014">
        <property type="protein sequence ID" value="KAG5483709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064648.1">
        <property type="nucleotide sequence ID" value="XM_067206839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KQD1"/>
    <dbReference type="SMR" id="A0A836KQD1"/>
    <dbReference type="GeneID" id="92360773"/>
    <dbReference type="KEGG" id="loi:92360773"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000828">
        <property type="term" value="F:inositol hexakisphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF104">
        <property type="entry name" value="KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="141"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="317"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="502"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="586"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="654"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="729"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="894"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="147"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="317"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="360"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="507"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="654"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="754"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="899"/>
            <end position="913"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5483709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1118" mass="119592" checksum="0568648E44F39EF8" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KQH9</accession>
    <name>A0A836KQH9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Presenilin</fullName>
            <ecNumber evidence="8">3.4.23.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_07329</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Golgi apparatus membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The PAL motif is required for normal active site conformation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase A22A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.-" evidence="8"/>
    <dbReference type="EMBL" id="JAFHLR010000015">
        <property type="protein sequence ID" value="KAG5483111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064607.1">
        <property type="nucleotide sequence ID" value="XM_067209224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KQH9"/>
    <dbReference type="SMR" id="A0A836KQH9"/>
    <dbReference type="GeneID" id="92363158"/>
    <dbReference type="KEGG" id="loi:92363158"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070765">
        <property type="term" value="C:gamma-secretase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.100">
        <property type="entry name" value="Presenilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001108">
        <property type="entry name" value="Peptidase_A22A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006639">
        <property type="entry name" value="Preselin/SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042524">
        <property type="entry name" value="Presenilin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10202">
        <property type="entry name" value="PRESENILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10202:SF13">
        <property type="entry name" value="PRESENILIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01080">
        <property type="entry name" value="Presenilin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01072">
        <property type="entry name" value="PRESENILIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00730">
        <property type="entry name" value="PSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5483111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="352" mass="38555" checksum="63E0451E221AFCE6" modified="2021-09-29" version="1">MSSGPLLDDARLSRGVGVRFVSLVVPVAATMLAVVWSLSCLSPIYVNSQVPPLSVVVDENNATSTGEKFAYALLAALIVVGCVVAATFAIVALYHFHLQFVLYGWLAFSAVSMFFILLWIWLDLFCTYFQIPYNVISMGIFVWNFGVVGLITLFYYSHPTVAQAYLVIASILIAWSLTALPEWTTWALLICIAMYDIVSVLWQQGPLHRLIKVAQERDEPIPGFIYDSAHSVAPIAQPARERPVRVPEAAAEPLVVTAQHSAPFKLGLGDFIFYSLLVGRASLSGFVSWGFCVVSILTGMVGTLLPLLLFRNSLGALPALPCSIFLSTIVFVLCRLLVEPLSTFVSHHLLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KRI7</accession>
    <name>A0A836KRI7_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_07588</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000012">
        <property type="protein sequence ID" value="KAG5484819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064931.1">
        <property type="nucleotide sequence ID" value="XM_067209471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KRI7"/>
    <dbReference type="GeneID" id="92363405"/>
    <dbReference type="KEGG" id="loi:92363405"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5484819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="241" mass="25746" checksum="3D24BBC010AB081C" modified="2021-09-29" version="1">MDIPFILVDTRTGFHVASSNLKFVNGEAKSKGALAVLCNTVFLQWVYIDESAGNVALKGAPLAFVVEKPLCSNVHGDVKYFQVKGNYLCVVFARRRHDLYEHFADRITEEAFCGRAGQLKAVGFVRGCAEGVFGDVIRALFERSGVTDYAVVAEGPSGTVHVGGGVLNERCGAVTAFGRQMLLSGIHVADDLVCYVDIRGDSVYAVAALCMSVSCIEELTGDAILCSWALSLCCGSTSANQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KRL9</accession>
    <name>A0A836KRL9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_07250</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAFHLR010000015">
        <property type="protein sequence ID" value="KAG5483037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064533.1">
        <property type="nucleotide sequence ID" value="XM_067209150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KRL9"/>
    <dbReference type="SMR" id="A0A836KRL9"/>
    <dbReference type="GeneID" id="92363084"/>
    <dbReference type="KEGG" id="loi:92363084"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001563">
        <property type="entry name" value="Protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967:SF57">
        <property type="entry name" value="AUXILIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="59"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="380"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="472"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="604"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="386"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="419"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="472"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="516"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="675"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5483037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="685" mass="75328" checksum="D0B89ACE360A5F23" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KSD1</accession>
    <name>A0A836KSD1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">LSCM4_06537</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000019">
        <property type="protein sequence ID" value="KAG5480965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063966.1">
        <property type="nucleotide sequence ID" value="XM_067208454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KSD1"/>
    <dbReference type="SMR" id="A0A836KSD1"/>
    <dbReference type="GeneID" id="92362388"/>
    <dbReference type="KEGG" id="loi:92362388"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005745">
        <property type="term" value="C:m-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000277">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050928">
        <property type="entry name" value="ATP-dep_Zn_Metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655:SF36">
        <property type="entry name" value="ZINC METALLOPEPTIDASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
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        <location>
            <begin position="149"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG5480965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="598" mass="64793" checksum="FD12B4DA270F93B4" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KSV4</accession>
    <name>A0A836KSV4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_06771</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000009">
        <property type="protein sequence ID" value="KAG5486064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065395.1">
        <property type="nucleotide sequence ID" value="XM_067208684.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92362618"/>
    <dbReference type="KEGG" id="loi:92362618"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141039">
        <property type="term" value="F:phosphatidylinositol 3-kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045022">
        <property type="term" value="P:early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051898">
        <property type="term" value="P:negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039724">
        <property type="entry name" value="WDR91"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13083">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13083:SF3">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="617"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="663"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="746"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="779"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="812"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="838"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="896"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="975"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1003"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1204"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1252"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="130"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="295"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="441"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="541"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="692"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="215"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="441"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="547"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5486064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1283" mass="136454" checksum="265D875B15D024A4" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KV45</accession>
    <name>A0A836KV45_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Guanine nucleotide-binding protein subunit beta-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_01865</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000022">
        <property type="protein sequence ID" value="KAG5479273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063366.1">
        <property type="nucleotide sequence ID" value="XM_067203907.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92357841"/>
    <dbReference type="KEGG" id="loi:92357841"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45333:SF1">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_625, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45333">
        <property type="entry name" value="MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="798"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="64"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="191"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="413"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="626"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="919"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1079"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1135"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1190"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1348"/>
            <end position="1387"/>
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        <property type="nucleotide sequence ID" value="XM_067210124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KYW4"/>
    <dbReference type="GeneID" id="92364058"/>
    <dbReference type="KEGG" id="loi:92364058"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5488030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="121" mass="13491" checksum="38827AC1139822E4" modified="2021-09-29" version="1">MRRPISYWRRGTLRWTRPHPRCSSQPSTKSHRGRCRARRQCVAGSHGRRQSYGDGAGGSRRDLQRLPHEGSHQRPQTEHHSAGGASQNAHVRLCTTASHTHTPLPPSSGWPRGGSRPPPLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836L0D2</accession>
    <name>A0A836L0D2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_07970</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">LSCM4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000013">
        <property type="protein sequence ID" value="KAG5484403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064896.1">
        <property type="nucleotide sequence ID" value="XM_067209846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836L0D2"/>
    <dbReference type="GeneID" id="92363780"/>
    <dbReference type="KEGG" id="loi:92363780"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF41">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033099436" description="Transmembrane 9 superfamily member" evidence="7">
        <location>
            <begin position="22"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="354"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="448"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="481"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="519"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="551"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5484403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="589" mass="66508" checksum="14CB93C94954EF7E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836L1E6</accession>
    <name>A0A836L1E6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TRASH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_06030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000011">
        <property type="protein sequence ID" value="KAG5485393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065130.1">
        <property type="nucleotide sequence ID" value="XM_067207956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836L1E6"/>
    <dbReference type="SMR" id="A0A836L1E6"/>
    <dbReference type="GeneID" id="92361890"/>
    <dbReference type="KEGG" id="loi:92361890"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.20:FF:000001">
        <property type="entry name" value="probable ribosome biogenesis protein RLP24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056366">
        <property type="entry name" value="Ribosomal_eL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055345">
        <property type="entry name" value="Ribosomal_eL24-rel_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023442">
        <property type="entry name" value="Ribosomal_eL24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF034186">
        <property type="entry name" value="PRK14891.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792:SF8">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN RLP24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01073">
        <property type="entry name" value="RIBOSOMAL_L24E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="TRASH" evidence="6">
        <location>
            <begin position="6"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="150"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="159"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5485393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="190" mass="22629" checksum="3023A127CD5DAB7D" modified="2021-09-29" version="1">MRIEQCSFCSAPIYPGHGQMFVRNDCKIFRFCSSKCRKNFGMKRNPMKLKWTKTFRKANGKELAVDSTMDFEQRRNIPVKYNRELLGDTLKVMKRVEKIKQRRQEDLWARRMEKARLQEKQEAASALKHNIDWIEDVEIKHKARDDLVAIQQEREDKKAKRREANKKRHQKQRQAEKAAGMTAFRSAKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836L3I5</accession>
    <name>A0A836L3I5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_07833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000006">
        <property type="protein sequence ID" value="KAG5487343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065840.1">
        <property type="nucleotide sequence ID" value="XM_067209710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836L3I5"/>
    <dbReference type="SMR" id="A0A836L3I5"/>
    <dbReference type="GeneID" id="92363644"/>
    <dbReference type="KEGG" id="loi:92363644"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000402">
        <property type="entry name" value="Flavoprotein monooxygenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
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    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
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                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    <dbReference type="PANTHER" id="PTHR12202">
        <property type="entry name" value="ESF1 HOMOLOG"/>
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    </dbReference>
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    </dbReference>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
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            </authorList>
            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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            </authorList>
            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="7"/>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059301.1">
        <property type="nucleotide sequence ID" value="XM_067203610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G238"/>
    <dbReference type="SMR" id="A0A836G238"/>
    <dbReference type="GeneID" id="92357544"/>
    <dbReference type="KEGG" id="loi:92357544"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004750">
        <property type="term" value="F:D-ribulose-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000004">
        <property type="entry name" value="Ribulose-phosphate 3-epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="RIBULOSE-5-PHOSPHATE-3-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5466411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="253" mass="27746" checksum="65DF09727B24D573" modified="2021-09-29" version="1">MATKFDHQDKSTYPNGRNKKQAIVPIISPSLMVADQTRLLQESLSVLSENGGSADWIHVDIVDGHFAPNFSFCPATVADLRKHLPNTFLDCHLVVADPIRWVDTFARAGASTFVFHYEAAEHPVAVCRKVREAGMVTGIALCPETPAEVLFPLIDAGEVDIVLVMCVRIGFAGQTFKPETVEKMRVLRQRYPYLLIQADGSITLDTIDLVAAAGANAIVPGRAVFKANNRKNSMQKLRGSIQKHIAMRAASHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G4K2</accession>
    <name>A0A836G4K2_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_01297</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059044.1">
        <property type="nucleotide sequence ID" value="XM_067203353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G4K2"/>
    <dbReference type="SMR" id="A0A836G4K2"/>
    <dbReference type="GeneID" id="92357287"/>
    <dbReference type="KEGG" id="loi:92357287"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="816"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="7"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="165"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="326"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="604"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="816"/>
            <end position="832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5466154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="847" mass="96295" checksum="F6191BC26DA65377" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G4L6</accession>
    <name>A0A836G4L6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_00982</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059698.1">
        <property type="nucleotide sequence ID" value="XM_067203048.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92356982"/>
    <dbReference type="KEGG" id="loi:92356982"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1000.11:FF:000002">
        <property type="entry name" value="Cytohesin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015403">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF375">
        <property type="entry name" value="LD29171P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09324">
        <property type="entry name" value="Sec7-like_HDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="4">
        <location>
            <begin position="951"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="43"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="515"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1435"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="102"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="531"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5467896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="2401" mass="258899" checksum="3EE1A6C4FA58D431" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G505</accession>
    <name>A0A836G505_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL15/eL18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_01572</name>
        <name evidence="6" type="ORF">LSCM4_01575</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">LSCM4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466421.1"/>
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    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="72"/>
            <end position="142"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5466421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5466424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="145" mass="16095" checksum="2F90B9EEBA8A905C" modified="2021-09-29" version="1">MPTRFKKCRHQRGSTFCGYGRVGKHRKHESGRGNAGGMHHHRINFDKYHPGYFGKLGMDHYHRKKNPAWKPTINLNNLTRLIAADEAARATRGGSLPVVDLPSCGYAKLLGNGHIQAPCIVKARYVSKLADKKIRKAGGAVVLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G5G6</accession>
    <name>A0A836G5G6_9TRYP</name>
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        <recommendedName>
            <fullName evidence="4">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="5" type="ORF">LSCM4_04109</name>
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        <name type="scientific">Leishmania orientalis</name>
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    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="426"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5475527.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="656" mass="71232" checksum="B77ABD0710898E8C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GB45</accession>
    <name>A0A836GB45_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
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            <taxon>Leishmania</taxon>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060335.1">
        <property type="nucleotide sequence ID" value="XM_067204783.1"/>
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    <dbReference type="GeneID" id="92358717"/>
    <dbReference type="KEGG" id="loi:92358717"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5470069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="121" mass="13600" checksum="A41ED35A8C2C6F43" modified="2021-09-29" version="1">MKQSHSKSSNVLVDVEDQPFRVATFQRTYSCGGHSERDDDMPSNLMNSRSNVPGMTPHELMAAHRSSLAEISKRADPDLHSLTLSRHQVEPEDIRHASFGDIPDDKYREALESFTFGRAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GF90</accession>
    <name>A0A836GF90_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000019">
        <property type="protein sequence ID" value="KAG5480912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063913.1">
        <property type="nucleotide sequence ID" value="XM_067208401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GF90"/>
    <dbReference type="GeneID" id="92362335"/>
    <dbReference type="KEGG" id="loi:92362335"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5480912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="93" mass="10529" checksum="7AA3C1284BA907EB" modified="2021-09-29" version="1">MKCEVGRDPLPFRILFSLTSSRGGRRAVQREAAARHAEGHRSTLRDRHSAFDASQLFSFAFRVRNRSRLSKLGSPLLPAHTHTHTHTLTHTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
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                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="738"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5481437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1130" mass="121057" checksum="D1667A82FBC82E59" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GGE8</accession>
    <name>A0A836GGE8_9TRYP</name>
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        <recommendedName>
            <fullName evidence="2">CSD domain-containing protein</fullName>
        </recommendedName>
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        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <location>
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            <end position="449"/>
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        <location>
            <begin position="250"/>
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    </feature>
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        <location>
            <begin position="503"/>
            <end position="525"/>
        </location>
    </feature>
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        <location>
            <begin position="503"/>
            <end position="516"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5471669.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GGR1</accession>
    <name>A0A836GGR1_9TRYP</name>
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        <recommendedName>
            <fullName evidence="10">Dynein regulatory complex protein 9</fullName>
        </recommendedName>
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        <name evidence="8" type="ORF">LSCM4_00449</name>
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        <name type="scientific">Leishmania orientalis</name>
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    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
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                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067202530.1"/>
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    <dbReference type="SMR" id="A0A836GGR1"/>
    <dbReference type="GeneID" id="92356464"/>
    <dbReference type="KEGG" id="loi:92356464"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:cilium organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="IQCG"/>
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        <property type="entry name" value="DYNEIN REGULATORY COMPLEX PROTEIN 9"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5465000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="659" mass="71574" checksum="6FF8EDE64F4A0415" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GI95</accession>
    <name>A0A836GI95_9TRYP</name>
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        <recommendedName>
            <fullName evidence="2">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">LSCM4_04143</name>
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        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062069.1">
        <property type="nucleotide sequence ID" value="XM_067206132.1"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
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        <location>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="KAG5475561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="410" mass="44242" checksum="2B73AFC55ECECEE7" modified="2021-09-29" version="1">MEYQIISSKGDKFALCIDDEMTVGDVKGVAAAMLDVPDDVIMTVSLNGKLLKNDAETWGELRGRLFRSQQPHPMQRKLFCNVTDRPVVESQSAEMLRMLPSKEEKKLEQEKEREKAAAMDSMVDSLADNPAFLESMLSMNPMIQNMQKKSPEVARMLKDPDTLRMILKSSVDPQRRREMERNAELQLAHIAALPGGQQMINHYMDQLAEDEEETYAQRQLRIGTSPADVSSELNQPDPTKEANNDPLPNPWATPVATASGALPPHAGAFSFGGTEAFPLGNAFGFPPTTAFSSSGAATSAMAPFFAGNLTAASSSGPDQAALNAMIEVMPSMKAQPLAPPTTTADVPSPSVAAALPSSSPPVLSEEVMQRGVAVLRDMGFEDEALCREALTACDGDAEAAVDYIAEHQAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GJY9</accession>
    <name>A0A836GJY9_9TRYP</name>
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        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_02463</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
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            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="KEGG" id="loi:92358426"/>
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    </dbReference>
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        <location>
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            <end position="634"/>
        </location>
    </feature>
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        <location>
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        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5469067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="674" mass="72154" checksum="A819D2255DE1E8DF" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GK08</accession>
    <name>A0A836GK08_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial RNA binding complex 1 subunit</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">LSCM4_02493</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
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            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067204522.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="92358456"/>
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    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="RESC9"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RESC9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="3"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="RESC9 middle region" evidence="2">
        <location>
            <begin position="495"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5469097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="898" mass="97702" checksum="CB0E6183BEE029A9" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GLV6</accession>
    <name>A0A836GLV6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL18 C-terminal eukaryotes domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_01362</name>
        <name evidence="9" type="ORF">LSCM4_01363</name>
        <name evidence="10" type="ORF">LSCM4_01365</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">LSCM4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059107.1">
        <property type="nucleotide sequence ID" value="XM_067203416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GLV6"/>
    <dbReference type="SMR" id="A0A836GLV6"/>
    <dbReference type="GeneID" id="92357350"/>
    <dbReference type="KEGG" id="loi:92357350"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00432">
        <property type="entry name" value="Ribosomal_L18_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.100:FF:000002">
        <property type="entry name" value="60S ribosomal protein L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_A">
        <property type="entry name" value="Ribosomal_uL18_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005485">
        <property type="entry name" value="Rbsml_uL18_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057268">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025607">
        <property type="entry name" value="Ribosomal_uL18_C_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410:SF12">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410">
        <property type="entry name" value="RIBOSOMAL PROTEIN L5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14204">
        <property type="entry name" value="Ribosomal_L18_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17144">
        <property type="entry name" value="Ribosomal_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00058">
        <property type="entry name" value="RIBOSOMALL5"/>
    </dbReference>
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        <property type="entry name" value="Translational machinery components"/>
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    </dbReference>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
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        <location>
            <begin position="245"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="256"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5466217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5466218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5466220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="305" mass="34029" checksum="9023235F8D248065" modified="2021-09-29" version="1">MPFVKVVKNKAYFKRFQVKYRRRREGKTDYHARRQMVLQDKTKFGSPKYRLVVRITNKDIIAQIVQAKIVGDEVLMAAYAHELPAFGIEHGLTNYAAAYATGLLLARRTLTKLGIADKFQGAKEADGSYSAVRTKKDDQGDDEERFPFKAILDVGLARTTTGARVFGVLKGAVDGGIAVPHRPNRFPGYNKEKSSLDAKVHRDRIFGKHVAEYLKQVKEEASSNPDEKCVQFSKYMSAKVAPESIEGMYKKAHAAIRADPSKSLPKKAKKEGGEHKSYKAKRMSGAEKRAAAKAKVAAIRQRLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GLY5</accession>
    <name>A0A836GLY5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_02841</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060413.1">
        <property type="nucleotide sequence ID" value="XM_067204861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GLY5"/>
    <dbReference type="GeneID" id="92358795"/>
    <dbReference type="KEGG" id="loi:92358795"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PP2A_PR55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11871">
        <property type="entry name" value="PROTEIN PHOSPHATASE PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="425"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="71"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="442"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5470147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="887" mass="95679" checksum="01A6B734AF7687AE" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GPE7</accession>
    <name>A0A836GPE7_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_06670</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the exportin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000010">
        <property type="protein sequence ID" value="KAG5485712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065296.1">
        <property type="nucleotide sequence ID" value="XM_067208585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GPE7"/>
    <dbReference type="SMR" id="A0A836GPE7"/>
    <dbReference type="GeneID" id="92362519"/>
    <dbReference type="KEGG" id="loi:92362519"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044189">
        <property type="entry name" value="XPO4/7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12596">
        <property type="entry name" value="EXPORTIN 4,7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12596:SF19">
        <property type="entry name" value="IMPORTIN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5485712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1106" mass="122674" checksum="BF2CB81A286E7012" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GSA9</accession>
    <name>A0A836GSA9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Guanine nucleotide-binding protein subunit beta-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_05442</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5478044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062951.1">
        <property type="nucleotide sequence ID" value="XM_067207383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GSA9"/>
    <dbReference type="SMR" id="A0A836GSA9"/>
    <dbReference type="GeneID" id="92361317"/>
    <dbReference type="KEGG" id="loi:92361317"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001582">
        <property type="entry name" value="WD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044285">
        <property type="entry name" value="PWP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14091">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14091:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="212"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="37"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5478044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="446" mass="48575" checksum="7093CF18BC0B1766" modified="2021-09-29" version="1">MLTTFCWVPKGAMKAIPILSTDTAAQARLKLRHQHPEYIEEEEQQPKGAKKTRAAGEETENEDDYVDDDDGVKTDIDDTLRVFAGGGPGAVLEEVESDDEEELEDTTLKPTDLVFTVACADAQTPRLEMYVYDEPEDNMYVHHDMEISAFPLCSSWLTDGTMSMLGVGTMLPFVEIWALDVMDSVEPAIVLGGCERQSYNYSKKMLKRNLKADSHTDAVLSVKWNTVAQNILVSGSADRTIKLWDLNQGGVCLGTYSEPEKVQSLDWHATEANWLLSGGFDASVVLRDCRQPDQVAQRYEMPGVIEHVEFVPSAGAVSQSAPVVMASTSGGHWAAFDTRMASSGAGHSPVTPLWQLQPHQADATFSCSRQVPGLFATGGKEGEIALWDGRDSSAAPKMIVSRSYKTGSVLSLSFHPNSPHILGAGGASGAPLVYTITSDIHDVFRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GSE1</accession>
    <name>A0A836GSE1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Attractin/MKLN-like beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_05504</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5478104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063011.1">
        <property type="nucleotide sequence ID" value="XM_067207443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GSE1"/>
    <dbReference type="SMR" id="A0A836GSE1"/>
    <dbReference type="GeneID" id="92361377"/>
    <dbReference type="KEGG" id="loi:92361377"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056737">
        <property type="entry name" value="Beta-prop_ATRN-MKLN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051568">
        <property type="entry name" value="LZTR1/Attractin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376">
        <property type="entry name" value="LEUCINE-ZIPPER-LIKE TRANSCRIPTIONAL REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376:SF1">
        <property type="entry name" value="LEUCINE-ZIPPER-LIKE TRANSCRIPTIONAL REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24981">
        <property type="entry name" value="Beta-prop_ATRN-LZTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Attractin/MKLN-like beta-propeller" evidence="3">
        <location>
            <begin position="10"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5478104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="378" mass="43163" checksum="D1F29F81FCA0BEFF" modified="2021-09-29" version="1">MPRPTPPFRHWSLVDCPSEDSPLGRIGHSFCANADGSKAYVYGGVNDTDSVSIYLDDLWQYDVINKRWREIELRGEKQHPRAFHTAVWYDTCMYIFGGCNGRGRFNKLFYISEDGECHPVVVRGALIPMTRYCHSAVVFGSTMYIFGGKCGGRNSNKRLQDLYRCDLSDPEWKECNQLGAIPPPRSAHTAMTYERTMIVFGGRNSGGECCEDFFVYSFDTSIWRRIDLPQVPMFGRARNSAAVHYGNIIVFGGWNGKKKLNDLFIYNVEANTFEFMYDIDREYPSRRECHVAVVCRNTMVVFGGRFRGHFMNDTTELYLGSKTGVDSMRDWLIMADPQLTGLATRLPLHHFAALKAHKDYVVPELPEEPLWPLIGHSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GTX6</accession>
    <name>A0A836GTX6_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_00414</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058597.1">
        <property type="nucleotide sequence ID" value="XM_067202496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GTX6"/>
    <dbReference type="GeneID" id="92356430"/>
    <dbReference type="KEGG" id="loi:92356430"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5464966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="81" mass="9077" checksum="8EA3F5905A43F372" modified="2021-09-29" version="1">MGPIRRSIEVFRSQTHSSGAPRVAQLPYPNPRRIPDLLSVMIGALHRRTGARTAALLQHRLLRTALKQCCAFSVTVADAWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GTY9</accession>
    <name>A0A836GTY9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ubiquinol-cytochrome C reductase hinge domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_03365</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">LSCM4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UQCRH/QCR6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060927.1">
        <property type="nucleotide sequence ID" value="XM_067205375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GTY9"/>
    <dbReference type="SMR" id="A0A836GTY9"/>
    <dbReference type="GeneID" id="92359309"/>
    <dbReference type="KEGG" id="loi:92359309"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.20:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.20">
        <property type="entry name" value="Ubiquinol-cytochrome C reductase hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003422">
        <property type="entry name" value="Cyt_b-c1_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023184">
        <property type="entry name" value="Ubol_cytC_Rdtase_hinge_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036811">
        <property type="entry name" value="Ubol_cytC_Rdtase_hinge_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15336:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15336">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 7.8 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02320">
        <property type="entry name" value="UCR_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81531">
        <property type="entry name" value="Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ubiquinol-cytochrome C reductase hinge" evidence="10">
        <location>
            <begin position="73"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5471810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="136" mass="15310" checksum="1F992F0F0A32D6A7" modified="2021-09-29" version="1">MYSHSLSSRSSFSLFFFAPYWQSLPPLTNGVPSLLHGDGSRAGQGELSLVHPRSRSQPQCIVDSFTMASDPVDIKLDLEKECLATECAKKVQAYNACLERIKSVDPMKEPHCYNQYFDIIHCVDVCVDPKLWPTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GU77</accession>
    <name>A0A836GU77_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-2-hydroxyglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="7">1.1.99.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_00583</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2</text>
            <dbReference type="Rhea" id="RHEA:21252"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:16782"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="EC" id="1.1.99.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the L2HGDH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.2" evidence="7"/>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058762.1">
        <property type="nucleotide sequence ID" value="XM_067202661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GU77"/>
    <dbReference type="SMR" id="A0A836GU77"/>
    <dbReference type="GeneID" id="92356595"/>
    <dbReference type="KEGG" id="loi:92356595"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047545">
        <property type="term" value="F:(S)-2-hydroxyglutarate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43104:SF3">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43104">
        <property type="entry name" value="L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="10">
        <location>
            <begin position="70"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5465131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="534" mass="58350" checksum="5CF088C8465624A7" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GUT3</accession>
    <name>A0A836GUT3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acireductone synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_00628</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058806.1">
        <property type="nucleotide sequence ID" value="XM_067202705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GUT3"/>
    <dbReference type="SMR" id="A0A836GUT3"/>
    <dbReference type="GeneID" id="92356639"/>
    <dbReference type="KEGG" id="loi:92356639"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043874">
        <property type="term" value="F:acireductone synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023943">
        <property type="entry name" value="Enolase-ppase_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01691">
        <property type="entry name" value="enolase-ppase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20371">
        <property type="entry name" value="ENOLASE-PHOSPHATASE E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20371:SF1">
        <property type="entry name" value="ENOLASE-PHOSPHATASE E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5465175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="374" mass="41049" checksum="FEA514BA8ADE0026" modified="2021-09-29" version="1">MLQNALSCFSAQLELTRLTDTVPDDINYEELAAIIQEKLQHAPGTTPGLFELLETKQIYLPAIDDAGDSITSLSGPLTVFLFDVEGTITPLPFVRQVMIPLAEARLESYMAAHFPEDKAFVDLLVALTESRSSPTAKTPTATSKGFSDALAVCKAHDWNDAAANNAARAEFCVFFHEEVKKGSTHAAVKAVQAAIWTEVFGEGKLQSQVFPDVNTFFRYAGRPIMAETTRIALYSTGSIASQKLVMGHTPYGDLNPFITAYFDPLLVGTKLTPKSYMKIRTLLAEQLDISPESMHIIFVTDNTSEASAAETSGAVDSSILCVRPLNNWVTFDTMLSINVPFIISFTQLMQRRCKIDLAKLVSDTKECIRPQGTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GVD6</accession>
    <name>A0A836GVD6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nodulin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_00292</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058479.1">
        <property type="nucleotide sequence ID" value="XM_067202378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GVD6"/>
    <dbReference type="GeneID" id="92356312"/>
    <dbReference type="KEGG" id="loi:92356312"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576:SF157">
        <property type="entry name" value="NODULIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UNCHARACTERIZED NODULIN-LIKE PROTEIN"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
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    </dbReference>
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    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="37"/>
            <end position="56"/>
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        <location>
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        <location>
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        <location>
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        <location>
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        <location>
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        </location>
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        <location>
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        <location>
            <begin position="581"/>
            <end position="602"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5464848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="623" mass="67138" checksum="058CED65AE8ED4C8" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GVZ5</accession>
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        <recommendedName>
            <fullName evidence="9">CNNM transmembrane domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="7" type="ORF">LSCM4_02230</name>
    </gene>
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        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061301.1">
        <property type="nucleotide sequence ID" value="XM_067204264.1"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="P:intracellular manganese ion homeostasis"/>
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    </dbReference>
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        <property type="term" value="P:magnesium ion homeostasis"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </source>
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        </source>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="426" mass="47269" checksum="208D301326D9027B" modified="2021-09-29" version="1">MEHLHHDSGEERLTSTQMFWYSVASVVCVAGAGFFVGLQIALFSIDRLFLRVLTTTGTPKERQQAKSLLAVLQLQHWTLVALVLMNAVFVMTLPILLETMFDELTALIVSITAVLFAGEVVPLAVFVRWAIPACSYFIHAIWLAIIVTAPVSYPMGKVLDRVLGHNEEPLDREDLAALIVGPQWEENEEESAMMEVTALRVGDGGDGARPMEQENSHYQLRESEVKMLQAAMLLSTDTVQQHLRTKVEAAFMLSSRDTLDRETILRILTAGYSRVPVYFGEDRRHIIGALIVNSLVSLCFSQPNPPPLVSDYPLREVMRLSHESSLYDAYLAFRDGTSNMAIIYDSSGAVVGLLTLNDVLATLYSADPVAPVALSEHYQRRQQKMVELVEGMKLLQASKRVVPAPLGTSRLGGLSRTNVYKDGVQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GXC2</accession>
    <name>A0A836GXC2_9TRYP</name>
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        <recommendedName>
            <fullName evidence="8">Signal peptidase complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_07226</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPCS3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000015">
        <property type="protein sequence ID" value="KAG5483016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067209129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GXC2"/>
    <dbReference type="GeneID" id="92363063"/>
    <dbReference type="KEGG" id="loi:92363063"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007653">
        <property type="entry name" value="SPC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12804">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 23 KD SUBUNIT SPC22/23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12804:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04573">
        <property type="entry name" value="SPC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5483016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="322" mass="35733" checksum="5C981E03D70BFF4E" modified="2021-09-29" version="1">MHSIRQRFFDIFASTLSALFLTALLTAASTILRDLTLRPRPVVSDVRVSSSSPLYRVRSSTLLSTKAPGAGIYYRPGNGNDGTEAAARRLPSNIVLVDMADRPEDSEEDRSRKAWQRKRLPEGFALGIRTVDRVVLYLSGSVDFSPCWDWNTKAIYASFVARFSSKSASKNDVVLLDAVLRSVSLPAQLAQLAELRRQERSAALLGSGNERAAVVAGAAAPLLTDVERQQLAAFEQTLRNSGHDHPSVYIDHIDKRLVLNNSFKYFVDAFDDTSLGGNTVEVVLRYQVMSYSGWAPLREDVLGHQVKVKMPENAMAMEWKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GXD9</accession>
    <name>A0A836GXD9_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061658.1">
        <property type="nucleotide sequence ID" value="XM_067205721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GXD9"/>
    <dbReference type="GeneID" id="92359655"/>
    <dbReference type="KEGG" id="loi:92359655"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001081">
        <property type="entry name" value="Ribonuclease inhibitor-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001083">
        <property type="entry name" value="Ribonuclease inhibitor-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052394">
        <property type="entry name" value="LRR-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="593"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="653"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5473655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="734" mass="80669" checksum="9F8DC68AB95C893A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GY00</accession>
    <name>A0A836GY00_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059178.1">
        <property type="nucleotide sequence ID" value="XM_067203487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GY00"/>
    <dbReference type="SMR" id="A0A836GY00"/>
    <dbReference type="GeneID" id="92357421"/>
    <dbReference type="KEGG" id="loi:92357421"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5466288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="37291" checksum="D600BB8EB4F7C858" modified="2021-09-29" version="1">MPGIDYSKWEQLKYSSSDTESDFGRDDEGHRGSRTAPQVTRLEYPSRVTLSPNGVQLEQVPPQASASPFPRTSASPTATPGDGTVATHPIHKRSSLAEMDAVTPIVVSDSTGDATGRQGDDRERVDATEDDEDLLYESLARNGGREGAHHWWTQTEDTVTVSFLVPWETKGKWVTEFRLYEAPASTAGESELYHAHLKISIQAPPARLMPARSDACASPAPLHIDQVFRYPVKLSEDLIDGCWQLLSMPKRHLRLLVVQLFKEPVGLGMTLWWDRCFLTDTASVIADTHTIPDRMRRMQATPGSKEKAQQFREAWADAHAEFRRRRAGAQAEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GYD3</accession>
    <name>A0A836GYD3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="2 5">2.7.7.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_07101</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>alpha-D-glucose 1-phosphate + UTP + H(+) = UDP-alpha-D-glucose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="2 5"/>
    <dbReference type="EMBL" id="JAFHLR010000018">
        <property type="protein sequence ID" value="KAG5481389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064068.1">
        <property type="nucleotide sequence ID" value="XM_067209005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GYD3"/>
    <dbReference type="SMR" id="A0A836GYD3"/>
    <dbReference type="GeneID" id="92362939"/>
    <dbReference type="KEGG" id="loi:92362939"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-alpha-D-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00897">
        <property type="entry name" value="UGPase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000001">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000002">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016267">
        <property type="entry name" value="UDPGP_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43511">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000806">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5481389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="498" mass="54486" checksum="6D4296AA59897B28" modified="2021-09-29" version="1">MEIDMKSISAAAQACVKKMRDANVSDASIRTFVAQHVMVSNGETGSIPDSAITPIESLGALDGLTVECDNSVLQSTVVMKLNGGLGTSMGLHCPKTLLEVKDGKTFLDFTALQVQYLRQHCSEHLRFMVMDSFHTSAGTKNFLKERYPWLYEVFDSEVELMQNQVPKILQDTLEPAAWAEDPECEWAPPGHGDIYTALYGSGKLQELVKKGYRYMFVSNGDNLGATVDKRVLAYMEEEKVDFLMEVCRRTESDKKGGHLARQTVRVKGKGGRPDADKTVLLLRESAQCPKEDMNSFQDISKYSFFNTNNLWVRLPALLATMEEHGGTLPLPVIRNEKTVDPSNSASPKVYQLETAMGAAISMFENASAIVVPRSRFAPVKTCADLLALRSDAYVVTDDFRLVLSDRCHGHPPVVDLDSAHYKTMSGFEKLVPHGVPSLVECQRVTVKGRVQFGTGNVLKGTVTIENADSTSTLVTPDGATLTDTTASPAAAADSEVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H140</accession>
    <name>A0A836H140_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Diacylglycerol acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LSCM4_04232</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the diacylglycerol acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062158.1">
        <property type="nucleotide sequence ID" value="XM_067206221.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836H140"/>
    <dbReference type="GeneID" id="92360155"/>
    <dbReference type="KEGG" id="loi:92360155"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07987">
        <property type="entry name" value="LPLAT_MGAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007130">
        <property type="entry name" value="DAGAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317:SF34">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03982">
        <property type="entry name" value="DAGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="389"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="428"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="472"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="518"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="545"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="640"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="670"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="710"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="754"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="907"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="933"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="978"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
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            <end position="1029"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
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            <end position="1073"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
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            <end position="1114"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
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            <end position="1183"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1195"/>
            <end position="1221"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1233"/>
            <end position="1254"/>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="851"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="867"/>
            <end position="876"/>
        </location>
    </feature>
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        <location>
            <begin position="877"/>
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        <source>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="EMBL" id="KAG5475650.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1622" mass="177176" checksum="17B52750E24071B2" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H142</accession>
    <name>A0A836H142_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosomal protein eL8/eL30/eS12/Gadd45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_01131</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Trypanosomatida</taxon>
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            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
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    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="RIBOSOMAL_L7AE"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
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        <location>
            <begin position="44"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        <source>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836H2Z0_9TRYP</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02397</name>
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    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059980.1">
        <property type="nucleotide sequence ID" value="XM_067204428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H2Z0"/>
    <dbReference type="GeneID" id="92358362"/>
    <dbReference type="KEGG" id="loi:92358362"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5469003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="710" mass="78461" checksum="75DE8E37347F06EE" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H365</accession>
    <name>A0A836H365_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cyclin 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_06752</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S51 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000009">
        <property type="protein sequence ID" value="KAG5486046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065377.1">
        <property type="nucleotide sequence ID" value="XM_067208666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H365"/>
    <dbReference type="SMR" id="A0A836H365"/>
    <dbReference type="GeneID" id="92362600"/>
    <dbReference type="KEGG" id="loi:92362600"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03146">
        <property type="entry name" value="GAT1_Peptidase_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000093">
        <property type="entry name" value="Cyclin 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005320">
        <property type="entry name" value="Peptidase_S51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20842:SF0">
        <property type="entry name" value="ALPHA-ASPARTYL DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20842">
        <property type="entry name" value="PROTEASE S51 ALPHA-ASPARTYL DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03575">
        <property type="entry name" value="Peptidase_S51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5486046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="335" mass="36072" checksum="2560107BE16F41C5" modified="2021-09-29" version="1">MFAQRINSIRACLAGSGDGAFGEPATIDHLISLVATPKTGVVSVAYVGTATYDLPEGQKEQTSLLVQRGCNVRAIPVADPSVKVVKDDDAHFIEREADIVLVSGGNTLYAVRRWEETGLAQLLRDAAARQVVLAGGSAGAICWFTSGHSDSADPATYLQPSLKMAVLKAGLVPQDQIAKTEAELTELSTSWSYIRTHGLNILPGLLCPHFDVTQGNGVRREEDFTKMLKRHHTERGIGVDHWALLILKGNGTYENVALPDKTRVATPGDTSPNATVPGIFILDVVDGAVQRRRMPTAGRLSDLLREPTGPVVSDPFERFHAMENPTPSSGSLMQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H574</accession>
    <name>A0A836H574_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063443.1">
        <property type="nucleotide sequence ID" value="XM_067207670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H574"/>
    <dbReference type="GeneID" id="92361604"/>
    <dbReference type="KEGG" id="loi:92361604"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5479732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="558" mass="58417" checksum="8400FC48E1A3AD54" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H5S0</accession>
    <name>A0A836H5S0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">LSCM4_07826</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JAFHLR010000006">
        <property type="protein sequence ID" value="KAG5487336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065833.1">
        <property type="nucleotide sequence ID" value="XM_067209703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H5S0"/>
    <dbReference type="SMR" id="A0A836H5S0"/>
    <dbReference type="GeneID" id="92363637"/>
    <dbReference type="KEGG" id="loi:92363637"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05573">
        <property type="entry name" value="STKc_ROCK_NDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000057">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000086">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000873">
        <property type="entry name" value="Protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF184">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE TRICORNERED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="71"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="17">
        <location>
            <begin position="383"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="235"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="238"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG5487336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="455" mass="51364" checksum="BD7CBFDBE46FF750" modified="2021-09-29" version="1">MNQIPTAQAGERGPNLSNARRGETSDDYARHKAAASRAFLENHYQSLLASARNGVGRAVGPRQKEPSFADFHLFKCIGRGAFGEVFVCKYKSDKTDTLYALKRLRKSDMITKKQVIHVRSEKDVLAEAAASNPWVVNLYRSFQDSLYLYMVMEYMPGGDMISWLCDKGIFDVESTRFYIAELCAAVASVHDMGFVHRDIKPDNILFGESGHIKLSDFGLSKRFVEKRGNLLDYDDRPSSSSGVEASVDETSAYASRKDAPPRSPSRGGAGTGIAHGRVREMFQSIVGSPGYIAPEILLRKPYGVGCDWWSVGVIMYEMLYGIPPFFSQNPNSTCHKIKNWREYLTFPPQRHIPEDAVDFMKRLICEPEERMTYDEICHHDFLKPMDMSRLRELQAPYIPVLSNPLDTKYFPEIKEPSAPLQLSEEQKVREVDPRGVMFADFRFNYSGNQSAPGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H622</accession>
    <name>A0A836H622_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060743.1">
        <property type="nucleotide sequence ID" value="XM_067205191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H622"/>
    <dbReference type="GeneID" id="92359125"/>
    <dbReference type="KEGG" id="loi:92359125"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032845692" evidence="1">
        <location>
            <begin position="21"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5471626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="301" mass="33032" checksum="C5EE6129E00F4D42" modified="2021-09-29" version="1">MSRTGAFLLTLAVVGSSCRCYHLPSLRSYCSLFARVRTNVTAAHVERVVHASALEHEGATLTRLWKAANAHPEEHIEGHAAVHVPQPTSDALEAPVMAEKSCLHASARRAPRLGSDHHRHLCRPGGAWIPSEWVLRRLAVVRGVCLRLEERAGVCARVQALLSAQRTGYRYMLWRPAFVLVAVAGCSPHMHERPLPVLTPWRGAQAEGPEMMARAADEGVATASSVHSAEDGATPRCWCPEKRCWPRIPPPRGNLAALHPVAGTLAAIVPQAEWPWSLTKALQGPEWSDVLMLRCALERYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H6T5</accession>
    <name>A0A836H6T5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LSCM4_06352</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAFHLR010000007">
        <property type="protein sequence ID" value="KAG5486884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065678.1">
        <property type="nucleotide sequence ID" value="XM_067208273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H6T5"/>
    <dbReference type="SMR" id="A0A836H6T5"/>
    <dbReference type="GeneID" id="92362207"/>
    <dbReference type="KEGG" id="loi:92362207"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000279">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000096">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895">
        <property type="entry name" value="CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895:SF32">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="10"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5486884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="297" mass="33594" checksum="5764F216D0FBD953" modified="2021-09-29" version="1">MGAPKRLGKYELGRTLGTGNFSKVKIARDTETGKEWAIKVIDKEQLVRERMEEQLKREIAVMKMLRQPNIIELHEVMQTSHHIYLVLELVTGGELFEKIASAKRFDEPTARHYFHQLICGIHYCHRQGIAHRDLKPENLLLDASDTLKISDFGLSNLQRTSASGGGTMLQTVCGTPNYVAPEVLKEQGYDGLKADIWSCGVVLFVMMAGYLPFDDENVNALFTKIERGEFRMARHFSTDARDLISRMLTVDPQERISLDGVIAHPWFRVDWNPAMLTQSESSPSPNTTQVSSAIKNM</sequence>
</entry>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
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                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067204230.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="loi:92358164"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5472871.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="109" mass="11645" checksum="7B24C030FFAEE3A1" modified="2021-09-29" version="1">MLPPTHVYSTVIHNSTAKEVTVIVTYSNMINNTSERHSIIVAAGGKGIAESRTYMENGVTFAIVITEVNINGSNTTLTAPFPGVDSPTNDYPIKILEDSGEVHLRGGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Uncharacterized protein</fullName>
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            <taxon>Leishmania</taxon>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000004">
        <property type="protein sequence ID" value="KAG5487784.1"/>
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    </dbReference>
    <dbReference type="RefSeq" id="XP_067065981.1">
        <property type="nucleotide sequence ID" value="XM_067209349.1"/>
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    <dbReference type="GeneID" id="92363283"/>
    <dbReference type="KEGG" id="loi:92363283"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1861"/>
            <end position="1883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1865"/>
            <end position="1883"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5487784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1883" mass="203764" checksum="470C325B34D7206B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H9A9</accession>
    <name>A0A836H9A9_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_03492</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
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            <taxon>Leishmania</taxon>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067205492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H9A9"/>
    <dbReference type="GeneID" id="92359426"/>
    <dbReference type="KEGG" id="loi:92359426"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5473426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="99" mass="10748" checksum="001A312A8514492C" modified="2021-09-29" version="1">MEGVGGEAAAAQVSGVIPHPGDVKQLRRAVREGLYRHAREPRVAALSVSLGQQQRCCRHCALAEGERCTAEPMARAHSCSAVVAFVRCVYFARRIFSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H9K9</accession>
    <name>A0A836H9K9_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">LSCM4_02210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Trypanosomatida</taxon>
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            <taxon>Leishmania</taxon>
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    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061281.1">
        <property type="nucleotide sequence ID" value="XM_067204244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H9K9"/>
    <dbReference type="SMR" id="A0A836H9K9"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="TPR-like_helical_dom_sf"/>
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        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN GUN1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47936">
        <property type="entry name" value="PPR_LONG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032520759" evidence="3">
        <location>
            <begin position="18"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="46"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5472885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="673" mass="72420" checksum="0A9B5D3D7DA1AE14" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HAF9</accession>
    <name>A0A836HAF9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycosyl hydrolase family 32 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_07487</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
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                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000004">
        <property type="protein sequence ID" value="KAG5487809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066006.1">
        <property type="nucleotide sequence ID" value="XM_067209374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HAF9"/>
    <dbReference type="SMR" id="A0A836HAF9"/>
    <dbReference type="GeneID" id="92363308"/>
    <dbReference type="KEGG" id="loi:92363308"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050551">
        <property type="entry name" value="Fructan_Metab_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018053">
        <property type="entry name" value="Glyco_hydro_32_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31953">
        <property type="entry name" value="BETA-FRUCTOFURANOSIDASE, INSOLUBLE ISOENZYME CWINV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00609">
        <property type="entry name" value="GLYCOSYL_HYDROL_F32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032991876" description="Glycosyl hydrolase family 32 N-terminal domain-containing protein" evidence="5">
        <location>
            <begin position="29"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 N-terminal" evidence="6">
        <location>
            <begin position="39"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5487809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="204" mass="23197" checksum="A059FC4ED16B496E" modified="2021-09-29" version="1">MIAPSFPSRRLILLLVAVAMMAAAVTVAMDGVPYEPIYHIRPPKNWVNDPNGPYRDPVTGKVHLYMQYNPNGPLWGDIAWYHVTSEDYVKWTRPESPVAVWADRWYDKWGAYSGTMMNNNYSEPVMVYTCTEPENIQRQCIANPPKSDLHGKRTLDTLVKSPLNVIMSEDMIPGIVATENFRDPTEWSQNSANAEPRLTAREKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HAL2</accession>
    <name>A0A836HAL2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Enoyl-CoA delta isomerase 1, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">3,2-trans-enoyl-CoA isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">LSCM4_03443</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Key enzyme of fatty acid beta-oxidation. Able to isomerize both 3-cis (3Z) and 3-trans (3E) double bonds into the 2-trans (2E) form in a range of enoyl-CoA species, with a preference for (3Z)-enoyl-CoAs over (3E)-enoyl-CoAs. The catalytic efficiency of this enzyme is not affected by the fatty acyl chain length.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2E)-tetradecenoyl-CoA = (3Z)-tetradecenoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:29847"/>
            <dbReference type="ChEBI" id="CHEBI:61405"/>
            <dbReference type="ChEBI" id="CHEBI:61968"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:29849"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(3Z)-decenoyl-CoA = (2E)-decenoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:77195"/>
            <dbReference type="ChEBI" id="CHEBI:61406"/>
            <dbReference type="ChEBI" id="CHEBI:195601"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:77196"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(3Z)-dodecenoyl-CoA = (2E)-dodecenoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:23716"/>
            <dbReference type="ChEBI" id="CHEBI:57330"/>
            <dbReference type="ChEBI" id="CHEBI:58543"/>
            <dbReference type="EC" id="5.3.3.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:23717"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(3Z)-octenoyl-CoA = (2E)-octenoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:46044"/>
            <dbReference type="ChEBI" id="CHEBI:62242"/>
            <dbReference type="ChEBI" id="CHEBI:85640"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:46045"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061383.1">
        <property type="nucleotide sequence ID" value="XM_067205446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HAL2"/>
    <dbReference type="SMR" id="A0A836HAL2"/>
    <dbReference type="GeneID" id="92359380"/>
    <dbReference type="KEGG" id="loi:92359380"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000034">
        <property type="entry name" value="Enoyl-CoA delta isomerase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF172">
        <property type="entry name" value="ISOMERASE, MITOCHONDRIAL, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00056147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00068317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00083575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG5473380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="303" mass="33763" checksum="EAF3FC6866FA926C" modified="2021-09-29" version="1">MQCLRMSHCVRPRWWRACSTAARVSDSTDLLMVRESPIERVLLFEMSNGRANVLTSEFISVLLKTIQDVCDPEKSTCRGIVLTSKNPGIFCAGLDLNEINTNLSQDRFAHYWGQFQQLFTTLHSLPVPLASAINGHAAAAGCIMALASDYRVMAKRHPTKPTNLTIGISAARHGFVVPPYVAGSMEHVVGFRKAEELLCTGSLLQADEALRIGLVDEVVEHHDEAVVPCLLFMEKLLELPSPAPYWMIKDMSRRHLVAPLCTDALRAQDTDSFYNLFSDTNVRETLAEHTRKITKSVESTRPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HAX4</accession>
    <name>A0A836HAX4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TatD related DNase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_08274</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000003">
        <property type="protein sequence ID" value="KAG5488049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066176.1">
        <property type="nucleotide sequence ID" value="XM_067210143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HAX4"/>
    <dbReference type="GeneID" id="92364077"/>
    <dbReference type="KEGG" id="loi:92364077"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050891">
        <property type="entry name" value="TatD-type_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060">
        <property type="entry name" value="TATD FAMILY DEOXYRIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060:SF47">
        <property type="entry name" value="TATD RELATED DNASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="472"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="544"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="482"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="550"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="590"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="678"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="710"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5488049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="743" mass="79384" checksum="1E4F5DA7BBE5D1F4" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HB00</accession>
    <name>A0A836HB00_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Clathrin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_06393</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasmic vesicle membrane</location>
            <topology evidence="1 6">Peripheral membrane protein</topology>
            <orientation evidence="1 6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Coated pit</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="6">Cytoplasmic face of coated pits and vesicles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the clathrin light chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000019">
        <property type="protein sequence ID" value="KAG5480825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063826.1">
        <property type="nucleotide sequence ID" value="XM_067208314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HB00"/>
    <dbReference type="SMR" id="A0A836HB00"/>
    <dbReference type="GeneID" id="92362248"/>
    <dbReference type="KEGG" id="loi:92362248"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000996">
        <property type="entry name" value="Clathrin_L-chain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01086">
        <property type="entry name" value="Clathrin_lg_ch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0168">Coated pit</keyword>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
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            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5480825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="291" mass="29693" checksum="E275668960B0B124" modified="2021-09-29" version="1">MEFGYPDSSAPTAGTPASPPDHMGSPFRGQVGSPHSPASTEGNSASAAPLPVHVGAPQQSQPCSPPVTSGTGMSSASLPAATATLRAPWDDDNGWGTPSVTAHHPAGAAAPVSPSSQSENHAAPPVPVVALANPGSPAEPRPTPVAMSQPASDGFVASSPPESSPNSPPTPPEKPSAVDSAKVEALKKQIASRTAAMDAATKAKETNIIAAAQEYLKALEAKREQEVMAAKAGHKQEQQAGTKKIDDFKKSGAVWNAVGMLVDLQRPNQYSKGTEQMRSVLSALNATPVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HC45</accession>
    <name>A0A836HC45_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_07122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000018">
        <property type="protein sequence ID" value="KAG5481410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064089.1">
        <property type="nucleotide sequence ID" value="XM_067209026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HC45"/>
    <dbReference type="SMR" id="A0A836HC45"/>
    <dbReference type="GeneID" id="92362960"/>
    <dbReference type="KEGG" id="loi:92362960"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1239"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1239"/>
            <end position="1249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5481410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1264" mass="135032" checksum="F4702574697390B9" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HD10</accession>
    <name>A0A836HD10_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_06952</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000017">
        <property type="protein sequence ID" value="KAG5481875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064235.1">
        <property type="nucleotide sequence ID" value="XM_067208861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HD10"/>
    <dbReference type="GeneID" id="92362795"/>
    <dbReference type="KEGG" id="loi:92362795"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050471">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433:SF7">
        <property type="entry name" value="ALPHA_BETA FOLD FAMILY, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="82"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5481875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="390" mass="42597" checksum="29CB1F6584332714" modified="2021-09-29" version="1">MVESDGAAHPTETAMASLLPQTETPKLAKPEDMGLPQDVLDELSRIYPRPPDDALVQVGRCASTGKVITLCYSAFGDPSDPCILLIMGMNVSSLLWDSRFCKYLADAGFYVIRYDNRDVGLSTHLDEYPSPCILRLALPAWASVGEGPVAYTLEDMAEDAAGLLKALKISQAHIVGCSMGGMIAQLLTLRHPEMVASLCLHSTSAGFAWPKPSLLLNILDQPVCPSDVHSVIDYRVRFFKAVAGDMPFYEREFRLGMWFDFARASYQGGARRHLTAIVRSKDRSAALKAHINRGCDAGKCSLGNERNSSSPCASGTTPSRYIPVVVLHGGKDPLIRLSSAQHLANCIRGARLVVFPRMGHYFSEEMYRPIADEIILNARTDATAMTETLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HD21</accession>
    <name>A0A836HD21_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_04108</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062034.1">
        <property type="nucleotide sequence ID" value="XM_067206097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HD21"/>
    <dbReference type="SMR" id="A0A836HD21"/>
    <dbReference type="GeneID" id="92360031"/>
    <dbReference type="KEGG" id="loi:92360031"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050502">
        <property type="entry name" value="Euk_RNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025">
        <property type="entry name" value="OS02G0815200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="377"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5475526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="494" mass="53571" checksum="AE67BDAD082BEDF5" modified="2021-09-29" version="1">MNARQTKVWEDASMCRSVSTISSSASTAEATAGNDVSSFLFDDYRDDAFCVKSRCRHWLSVGHLSLTTTDTELKSLFYPYGADEAFTAWEGASMTGFVGFDSPEMAELAAQKMHAFIPRRQSQALTVRSVTLEEVSQARSKGPKSLVAVLYSECATQGISAVIRRSKSPAAMARDVAVEVARASPIVLQRLMAAFSDLSPQWFGFAAFSEELLKSLLGSLLEASGMNTAQAINCGTVVGNLFQMHMITGDPYYLAARLLQRAGHRLAQLEGVCALAHTCALLPDCHMSRASFWAQVADTATKVTDQETSNALLDHLRRYTKTSAYAAATSTSLLSSSAPPPSVFSTVPCTPPKAARQQMVPQRACPQHLRQDEMKRRTVYVSHLPGLLPQSMLLELLNAAGPVNKVRICAGTGYCTLFAFVEMRTLEGAQRVMCMNGLQLMGFAIRVQTARNAVQDVLKEDARFDASGALIQPCLFGMSQAPLSKCLTSADGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HE06</accession>
    <name>A0A836HE06_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic initiation factor 4E family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062284.1">
        <property type="nucleotide sequence ID" value="XM_067206981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HE06"/>
    <dbReference type="SMR" id="A0A836HE06"/>
    <dbReference type="GeneID" id="92360915"/>
    <dbReference type="KEGG" id="loi:92360915"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF20">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E TYPE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5476051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="182" mass="20340" checksum="6F3C61FCAB44B7B6" modified="2021-09-29" version="1">MADCSPTKEGTSSAPLHPLKDKWFVFYIPASKGNEYEHETKELGYVSSIEEVYSTINTLPPITLLPNDDNLVFSRNKIEPQFESFPGGMRFSIFCKTKTQCREAMTYVVAVVLGEAISRDACKGECLCDIVRIGHKGSAMYKESVRIEVWAHQSPYNVAMEKYLVSTLSAIPGITVSSRPFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HF39</accession>
    <name>A0A836HF39_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_04274</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062198.1">
        <property type="nucleotide sequence ID" value="XM_067206261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HF39"/>
    <dbReference type="GeneID" id="92360195"/>
    <dbReference type="KEGG" id="loi:92360195"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001063">
        <property type="entry name" value="Protein kinase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000875">
        <property type="entry name" value="Protein kinase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF107">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 11A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="278"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="51"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="301"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="380"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="901"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="51"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="381"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="415"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="931"/>
            <end position="940"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5475690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="961" mass="102782" checksum="CE8114D84394C849" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HGE3</accession>
    <name>A0A836HGE3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">LSCM4_04590</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">LSCM4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062782.1">
        <property type="nucleotide sequence ID" value="XM_067206573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HGE3"/>
    <dbReference type="SMR" id="A0A836HGE3"/>
    <dbReference type="GeneID" id="92360507"/>
    <dbReference type="KEGG" id="loi:92360507"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16527">
        <property type="entry name" value="RING-HC_PEX10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025654">
        <property type="entry name" value="PEX2/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350:SF0">
        <property type="entry name" value="PEROXISOME BIOGENESIS FACTOR 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 18" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="19">
        <location>
            <begin position="221"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAG5477371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="302" mass="33436" checksum="5F6CE149CB5714E0" modified="2021-09-29" version="1">MQTATAPFILRSAYKDAYISEMQITRPITELMINTFGAQLTNKYDAHIPAVASSLYTLCSMSRVQTLGQEFCDLLPVTKAHPWQTVGPARVFLLAVLQLVEPTAVFWAARKLFPDMSAADVDEVLKKVVLCALFLFERFGTLPHRIVRMRFLSLKPSRTLQDSDGAPGSYVVLGLVLLVELVVRLWRYSKERKSREAKRSTEAGATTSSDEDAEDARAGKCMLCLSNRKHPTATNCGHIFCWKCIAEWIQSNPQEAVCPFCRQHITTQSLVPLFFYVSKEPPRVGTATDAAASPASSGTSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HIA6</accession>
    <name>A0A836HIA6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRO1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_04574</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BROX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062766.1">
        <property type="nucleotide sequence ID" value="XM_067206557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HIA6"/>
    <dbReference type="SMR" id="A0A836HIA6"/>
    <dbReference type="GeneID" id="92360491"/>
    <dbReference type="KEGG" id="loi:92360491"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038898">
        <property type="entry name" value="BROX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23032">
        <property type="entry name" value="BRO1 DOMAIN-CONTAINING PROTEIN BROX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23032:SF13">
        <property type="entry name" value="BRO1 DOMAIN-CONTAINING PROTEIN BROX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="2">
        <location>
            <begin position="7"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5477355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="389" mass="43547" checksum="0566EC57605FC9D4" modified="2021-09-29" version="1">MFNNDAHKYVLPTIPVRQTNKPGINSHVEANLSPSEKKDFDKKRDACISFFEDFRKHLGRKGNSVDEKLSTSAGCEKYVQDLVDLVDAYASSLVNIVSKTPKFASLQYYYWSSSLTDKQEMAFDDYRYELLGIYYNVGAILMNIAQYLLCVRVTVGTLSFLEKDAYRVLIKASIYFNFCRDIVGNMKEHEIGVAQIPVPLDVDKGMAVFLESLALAQAQEIGVSKAFSADPKEGTETTARLSHQLFLMYETVCTNARTVNTRNETFAEISALVAVKCDIFRALAYQHAAAHRFNKDPGAGLSLLNQGVEHARVAENYLAMSGKGKLKIPFSGERFVKVCNTFIRNNTERLTKINMLVHRAKPDTTKALLPPPQPLAMRPSVSLPFQLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HIL8</accession>
    <name>A0A836HIL8_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_04819</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000023">
        <property type="protein sequence ID" value="KAG5478586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063247.1">
        <property type="nucleotide sequence ID" value="XM_067206800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HIL8"/>
    <dbReference type="GeneID" id="92360734"/>
    <dbReference type="KEGG" id="loi:92360734"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5478586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="338" mass="38617" checksum="F1541B6C0347754C" modified="2021-09-29" version="1">MWALTSQPIQNAEALQLMERYMERNALQSNKWLLPRHLALLAVRSLYPAQLVLPTSSVIQLPLCAVPFCSLPPSRKREILRLYPPPYSPPASCLFLENSGDAMRWRSASMLECFDAAFVRSDSLSPRQYLLCAPDCATSMEVEEEVTVFNAQETNNPFLVDTDLLHRDLLKSVTFQHSIASALTTIAAQFRYTSFDWVEEEAASAAGLRVCAGTSPHLVSCVETLRVVHISQLPSERQRELVDSVPRTTLIKSMSVSFVFYSERWRHYRSVEMTRPLVHRDIPRSGTPEIQDLQPLLWVAVNSNMKFCGNVTERERLIRRLYYNSQQLEMDARPAPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HJ80</accession>
    <name>A0A836HJ80_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA (guanine(37)-N1)-methyltransferase</fullName>
            <ecNumber evidence="9">2.1.1.228</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">M1G-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">tRNA [GM37] methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">tRNA methyltransferase 5 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_05566</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>guanosine(37) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36899"/>
            <dbReference type="Rhea" id="RHEA-COMP:10145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10147"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.228"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="9">Predominantly in the mitochondria and in the nucleus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TRM5 / TYW2 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.228" evidence="9"/>
    <dbReference type="EMBL" id="JAFHLR010000016">
        <property type="protein sequence ID" value="KAG5482313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064319.1">
        <property type="nucleotide sequence ID" value="XM_067207505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HJ80"/>
    <dbReference type="GeneID" id="92361439"/>
    <dbReference type="KEGG" id="loi:92361439"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052906">
        <property type="term" value="F:tRNA (guanine(37)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002939">
        <property type="term" value="P:tRNA N1-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.110:FF:000005">
        <property type="entry name" value="tRNA (guanine(37)-N1)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000765">
        <property type="entry name" value="tRNA (guanine(37)-N1)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.110">
        <property type="entry name" value="Met-10+ protein-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03152">
        <property type="entry name" value="TRM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056743">
        <property type="entry name" value="TRM5-TYW2-like_MTfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056744">
        <property type="entry name" value="TRM5/TYW2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025792">
        <property type="entry name" value="tRNA_Gua_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245:SF43">
        <property type="entry name" value="TRNA (GUANINE(37)-N1)-METHYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245">
        <property type="entry name" value="TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02475">
        <property type="entry name" value="TRM5-TYW2_MTfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25133">
        <property type="entry name" value="TYW2_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51684">
        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase TRM5/TYW2-type" evidence="11">
        <location>
            <begin position="277"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="81"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="199"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="417"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="455"/>
            <end position="456"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="484"/>
            <end position="485"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="519"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5482313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="677" mass="72327" checksum="0396B67041E198D4" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HJM4</accession>
    <name>A0A836HJM4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chromatin binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_05976</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000011">
        <property type="protein sequence ID" value="KAG5485340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065077.1">
        <property type="nucleotide sequence ID" value="XM_067207903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HJM4"/>
    <dbReference type="SMR" id="A0A836HJM4"/>
    <dbReference type="GeneID" id="92361837"/>
    <dbReference type="KEGG" id="loi:92361837"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051709">
        <property type="entry name" value="Ub-ligase/GTPase-reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45622:SF70">
        <property type="entry name" value="SECRETION-REGULATING GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45622">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="19"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="80"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5485340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="764" mass="80530" checksum="44A1235A62310D0B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HKX7</accession>
    <name>A0A836HKX7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PB1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_05869</name>
    </gene>
    <organism evidence="3 4">
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            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
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                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
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                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="2016"/>
            <end position="2041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="2064"/>
            <end position="2076"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5486075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2531" mass="272855" checksum="ADBAC9759EAB9E08" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HLS1</accession>
    <name>A0A836HLS1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_04827</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000014">
        <property type="protein sequence ID" value="KAG5483678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064617.1">
        <property type="nucleotide sequence ID" value="XM_067206808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HLS1"/>
    <dbReference type="SMR" id="A0A836HLS1"/>
    <dbReference type="GeneID" id="92360742"/>
    <dbReference type="KEGG" id="loi:92360742"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5483678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="732" mass="79494" checksum="BD5BA528E8F9CD2E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HLT4</accession>
    <name>A0A836HLT4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glycerol-3-phosphate dehydrogenase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_06122</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">LSCM4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000020">
        <property type="protein sequence ID" value="KAG5480356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063687.1">
        <property type="nucleotide sequence ID" value="XM_067208047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HLT4"/>
    <dbReference type="GeneID" id="92361981"/>
    <dbReference type="KEGG" id="loi:92361981"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004368">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.870">
        <property type="entry name" value="Alpha-glycerophosphate oxidase, cap domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031656">
        <property type="entry name" value="DAO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038299">
        <property type="entry name" value="DAO_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985:SF11">
        <property type="entry name" value="DEHYDROGENASE (FAD-DEPENDENT), PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16901">
        <property type="entry name" value="DAO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="75"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-glycerophosphate oxidase C-terminal" evidence="7">
        <location>
            <begin position="715"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5480356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="789" mass="83270" checksum="FF9A1EBB203E44AF" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HNC0</accession>
    <name>A0A836HNC0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tryptophan synthase beta chain-like PALP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_07779</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000006">
        <property type="protein sequence ID" value="KAG5487290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065787.1">
        <property type="nucleotide sequence ID" value="XM_067209657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HNC0"/>
    <dbReference type="SMR" id="A0A836HNC0"/>
    <dbReference type="GeneID" id="92363591"/>
    <dbReference type="KEGG" id="loi:92363591"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030378">
        <property type="term" value="F:serine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018114">
        <property type="term" value="F:threonine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070179">
        <property type="term" value="P:D-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43050">
        <property type="entry name" value="SERINE / THREONINE RACEMASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43050:SF1">
        <property type="entry name" value="SERINE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="4">
        <location>
            <begin position="17"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5487290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="337" mass="36937" checksum="B30A7FE433F6118B" modified="2021-09-29" version="1">MPTFSEIMAARKALDGYVYETPIIESNALHGKTRHESVLLKCENLQRTGSYHVRGMTYRVIRAKEEDLGVNHFVTHSSGNGGAALACAASNFQSTAHVVVPEDTNALITRSIRLYHGNFYYCKPELQSRVEMEARLQAEFNRPSGKKRNQSVIVNPYSDEAIIAGHGTAGIELMLQTDCSVDCVVIPVGGGALLAGAAIAVKGMKPHVGVFAAELTVPPDHYTVFKRGEVIEARKSKGDDQRPKNKHGIRTELTDLANTYIDRYVDGVVHVSKEEMCYAFRYVYERCKLVVDTNAAIAVAAVLACPPELSNYRRVCIILSGGNVDLNDVPKIATARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HPF5</accession>
    <name>A0A836HPF5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BRCA2 OB1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_06079</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000020">
        <property type="protein sequence ID" value="KAG5480313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063644.1">
        <property type="nucleotide sequence ID" value="XM_067208004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HPF5"/>
    <dbReference type="SMR" id="A0A836HPF5"/>
    <dbReference type="GeneID" id="92361938"/>
    <dbReference type="KEGG" id="loi:92361938"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04493">
        <property type="entry name" value="BRCA2DBD_OB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000438">
        <property type="entry name" value="DNA repair protein BRCA2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015525">
        <property type="entry name" value="BRCA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015187">
        <property type="entry name" value="BRCA2_OB_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002093">
        <property type="entry name" value="BRCA2_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11289:SF0">
        <property type="entry name" value="BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11289">
        <property type="entry name" value="BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN BRCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09103">
        <property type="entry name" value="BRCA-2_OB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00634">
        <property type="entry name" value="BRCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BRCA2 OB1" evidence="5">
        <location>
            <begin position="433"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="35"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="225"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5480313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1174" mass="125716" checksum="B602B91D7FF62F2E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HPI3</accession>
    <name>A0A836HPI3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transmembrane protein 231</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LSCM4_06124</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">LSCM4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM231 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000020">
        <property type="protein sequence ID" value="KAG5480358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063689.1">
        <property type="nucleotide sequence ID" value="XM_067208049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HPI3"/>
    <dbReference type="GeneID" id="92361983"/>
    <dbReference type="KEGG" id="loi:92361983"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060170">
        <property type="term" value="C:ciliary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035869">
        <property type="term" value="C:ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032880">
        <property type="term" value="P:regulation of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019306">
        <property type="entry name" value="TMEM231"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14605">
        <property type="entry name" value="CHST5 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14605:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 231"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10149">
        <property type="entry name" value="TM231"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG5480358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="374" mass="41862" checksum="E9FA8B2AEDAA7CBA" modified="2021-09-29" version="1">MFLSLYREHYGVRYTPRGVASWLFYVLCLSTILVVPIIIALSMQSFWAKASYFYAMPGVTFTGQCAVRVSTVLGKEYLWTCFDLFHGALQETSLSILPYFAIFEDDRDGDGRIDYANFLISFPLGGALEVSSPYAPTTAAESGGADAPTSQRDAILEVSFLPEFVYSISDDLVKVNMTAAPLLRYQRNPLPKGFGNATTATSSTYSWSGAPVCALTKADMLFYTTQSLINSPYVSHTHTYTSSPLQELARQPADLLDLPHFAANYAARNQSVVLRSYVEAAGGLDVLRSDVSVVRGLWEDLDDLNAFTWYIQLRIPPAKVQYVPSLAEALKWAWIQYFVIAYVVQWLVWKLRMVLVKMGLISSRAVFSTMRRQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HQ66</accession>
    <name>A0A836HQ66_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_06480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000019">
        <property type="protein sequence ID" value="KAG5480910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063911.1">
        <property type="nucleotide sequence ID" value="XM_067208399.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836HQ66"/>
    <dbReference type="GeneID" id="92362333"/>
    <dbReference type="KEGG" id="loi:92362333"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39670">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39670:SF2">
        <property type="entry name" value="PARAFLAGELLAR ROD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="3413"/>
            <end position="3438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="3726"/>
            <end position="3745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="957"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1570"/>
            <end position="1601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1664"/>
            <end position="1703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1719"/>
            <end position="1778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1974"/>
            <end position="1993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2648"/>
            <end position="2687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2768"/>
            <end position="2825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2877"/>
            <end position="2924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3642"/>
            <end position="3694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1570"/>
            <end position="1585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1664"/>
            <end position="1675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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        <source>
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        </source>
    </evidence>
    <sequence length="3770" mass="401584" checksum="383A07F3FF92D9D3" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="105" mass="11644" checksum="C5BEF999D2792449" modified="2021-09-29" version="1">MEEAEASLRRTLQAAHAALRSSYTVTSSLATQSETLTALEERLEENEKGWRQGRREMRRTRHWYVALVHWLRCGGGASLSQVAGKSPGVTDGDEAAARGDTRDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836HXG7_9TRYP</name>
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        <recommendedName>
            <fullName evidence="5">PPPDE domain-containing protein</fullName>
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        <name evidence="6" type="ORF">LSCM4_06824</name>
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    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeSI family.</text>
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    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG5486116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_067208736.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
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        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378:SF80">
        <property type="entry name" value="IP06716P-RELATED"/>
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        <property type="entry name" value="PPPDE"/>
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        <location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5486116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="220" mass="24639" checksum="DCE609BD3D80FD2D" modified="2021-09-29" version="1">MHSNSVTIVSPSQSGGAGKSDAPVMPAGHEDAANQPNAVFVNVYDIMKSNSWLWSVGLGVHHAGIQVYGEEYQYGRCEEGTGVRAVEPRHSPPHIFREQFYVGQTQLSAREVQDLFASFQRRELWLGSRYHLVKHNCIHFAHAFCEALLPPEVRVAQMRMAPPSIYQSAYMEEVEVNGRRYSLPVLIPPHVDRLGNYAASFLPESALQMLDSIDNPFRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836I0V1</accession>
    <name>A0A836I0V1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase ESCO zinc-finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_08215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000003">
        <property type="protein sequence ID" value="KAG5487991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066118.1">
        <property type="nucleotide sequence ID" value="XM_067210085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836I0V1"/>
    <dbReference type="GeneID" id="92364019"/>
    <dbReference type="KEGG" id="loi:92364019"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028005">
        <property type="entry name" value="AcTrfase_ESCO_Znf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13878">
        <property type="entry name" value="zf-C2H2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase ESCO zinc-finger" evidence="2">
        <location>
            <begin position="167"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="583"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="596"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5487991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="621" mass="64801" checksum="9FD37001E02C16E8" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836I141</accession>
    <name>A0A836I141_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Thymine dioxygenase JBP1</fullName>
            <ecNumber evidence="4">1.14.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">J-binding protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Thymidine hydroxylase JBP1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">LSCM4_06841</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Dioxygenase that catalyzes the first step of DNA base J (beta-d-glucosyl-HOMedU) biosynthesis by converting thymine to 5-hydroxymethyluracil (HOMedU). DNA base J is a hypermodified thymidine residue found in the genome of kinetoplastid parasites, which is localized primarily to repetitive DNA, namely the telomeres, and is implicated in the regulation of antigenic variation. Also specifically binds to base J-containing DNA (J-DNA). Involved in propagation and maintenance of DNA base J synthesis initiated by JBP2 by specifically binding already synthesized DNA base J and propagating J synthesis. Thymine dioxygenase activity and J-DNA-binding are independent functions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>thymine + 2-oxoglutarate + O2 = 5-hydroxymethyluracil + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:10316"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16964"/>
            <dbReference type="ChEBI" id="CHEBI:17821"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="EC" id="1.14.11.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="13">Monomer. Binds to DNA as a monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TET family. JBP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.6" evidence="4"/>
    <dbReference type="EMBL" id="JAFHLR010000009">
        <property type="protein sequence ID" value="KAG5486133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065464.1">
        <property type="nucleotide sequence ID" value="XM_067208753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836I141"/>
    <dbReference type="SMR" id="A0A836I141"/>
    <dbReference type="GeneID" id="92362687"/>
    <dbReference type="KEGG" id="loi:92362687"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050341">
        <property type="term" value="F:thymine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070580">
        <property type="term" value="P:base J metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1440:FF:000001">
        <property type="entry name" value="Thymine dioxygenase JBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1440">
        <property type="entry name" value="JBP1, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024779">
        <property type="entry name" value="2OGFeDO_JBP1/TET_oxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041241">
        <property type="entry name" value="DB_JBP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043111">
        <property type="entry name" value="DB_JBP1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18526">
        <property type="entry name" value="DB_JBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12851">
        <property type="entry name" value="Tet_JBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2OGFeDO JBP1/TET oxygenase" evidence="17">
        <location>
            <begin position="107"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Thymine dioxygenase JBP1 DNA-binding" evidence="18">
        <location>
            <begin position="396"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF12851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF18526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAG5486133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="814" mass="91704" checksum="9DBDE076E67C1FD2" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836I479</accession>
    <name>A0A836I479_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prefoldin subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_08126</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">LSCM4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000005">
        <property type="protein sequence ID" value="KAG5487678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065966.1">
        <property type="nucleotide sequence ID" value="XM_067209999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836I479"/>
    <dbReference type="SMR" id="A0A836I479"/>
    <dbReference type="GeneID" id="92363933"/>
    <dbReference type="KEGG" id="loi:92363933"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23161">
        <property type="entry name" value="Prefoldin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000003">
        <property type="entry name" value="Prefoldin subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21431">
        <property type="entry name" value="PREFOLDIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21431:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="93"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="136" mass="15760" checksum="874C7103B38765CA" modified="2021-09-29" version="1">MSQIHSDIKKLNDVLRPILKELQELGDKKGKLIEARRQLGAQKNENELVRDELNKLEPDATVYKLIGPALVPQDQSDAKTIISNRLDYINGEIKRSDTSIAELDRKEAELQKKAQELYRKMQERQAQLIQQQQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836K6F3</accession>
    <name>A0A836K6F3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">CAF1B/HIR1 beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LSCM4_00265</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat HIR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="loi:92356288"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:ribosome"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
    </dbReference>
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        <property type="entry name" value="PTHR15271"/>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
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        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15271">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15271:SF4">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT B"/>
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    </dbReference>
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        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
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    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 10" id="KW-0853">WD repeat</keyword>
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            <end position="79"/>
        </location>
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    </feature>
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        </location>
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    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF24105"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="678" mass="72933" checksum="71A313014F1AC10F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836K973_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_00222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058412.1">
        <property type="nucleotide sequence ID" value="XM_067202311.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92356245"/>
    <dbReference type="KEGG" id="loi:92356245"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
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        <location>
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            <end position="1340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="720"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="737"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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        <location>
            <begin position="1320"/>
            <end position="1337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5464781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KAK0</accession>
    <name>A0A836KAK0_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_01612</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059351.1">
        <property type="nucleotide sequence ID" value="XM_067203660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KAK0"/>
    <dbReference type="GeneID" id="92357594"/>
    <dbReference type="KEGG" id="loi:92357594"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5466461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="481" mass="54711" checksum="8E40C72134C334A7" modified="2021-09-29" version="1">MRSVARCCSCNVGMVLAWPPSRSTAAALGVACAAPLTQHRYQTRIPNKGYRQQPAVPDRMKDAMTTFGVDMHNVSADDDPPYVQEHQRQRMVQEVMSSSQNLKSLSKLDRLRSALDRVRNEPAGHEKWNEVYLFLRTTEMCTEVVANDSDVMPKGKKLWIEMELCEEKRVPVLMTLPNGMPVLPIFTMEEYMDAYFSRTNVFDSCWFPVPRNGTQWEEFCKLSFPVCVTGSIQHFSTLATVALGSHQLGILVNPGMRTSKFISYPEMVSLTRLRQQQRKSRPRTVTRCAATDGSSTAAAVEESLFDENLMMTFDTTKMPLTRLEPQELAACVAQRPPIPPVAELELHLLLHVYPEIESVYIRTVDRPRWRRMLGASEKMTQIDVVCDPEHKPDKCFFEHLRHWSFMKEFNSDVHVELTSQAPVQVSSTGAFMCVYSNEVDGKPLRAMSTFKGRTLADQLGFNEPITDAQGNKPYERNVSYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KBC3</accession>
    <name>A0A836KBC3_9TRYP</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">LSCM4_02873</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470179.1"/>
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        <property type="nucleotide sequence ID" value="XM_067204893.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
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            <begin position="8"/>
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        </location>
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            <begin position="170"/>
            <end position="205"/>
        </location>
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        <location>
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        </location>
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        </location>
    </feature>
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            <begin position="511"/>
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        </location>
    </feature>
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        <location>
            <begin position="61"/>
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        </location>
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            <begin position="74"/>
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        </location>
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        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="2">
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            <begin position="762"/>
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        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5470179.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="782" mass="85469" checksum="0AD5D5F3B4ED297F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KBG2</accession>
    <name>A0A836KBG2_9TRYP</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="1" type="ORF">LSCM4_00130</name>
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        <name type="scientific">Leishmania orientalis</name>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464690.1"/>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039963">
        <property type="entry name" value="Unchar_22kDa"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR38828:SF4">
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5464690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="195" mass="22582" checksum="60EA46FC5969905B" modified="2021-09-29" version="1">MGTMAFSYDHLASGRQLTAEELEKQIERLTAPRHVVERRDPFDVCPTKRIPAEAITKMTDRLYTQSVQHRQERLAAAEEAAYGAHTRGSALCAASLTPEDREQSVKRLYRDSVERRQANMEQLRRQYQYQRPANKTVPLNTFVEHMYYDRLEAKKKTEKRLYETYLAPTEIHTGTISREQADEASNRLCTTRTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KD03</accession>
    <name>A0A836KD03_9TRYP</name>
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        <recommendedName>
            <fullName evidence="7">Ribosomal protein l35a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_00973</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059689.1">
        <property type="nucleotide sequence ID" value="XM_067203039.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="92356973"/>
    <dbReference type="KEGG" id="loi:92356973"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0005840">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:translation"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="60S ribosomal protein L35a"/>
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    </dbReference>
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        <property type="entry name" value="translation elongation factor selb, chain A, domain 4"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_eL33_sf"/>
    </dbReference>
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        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
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        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35A"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5467887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="144" mass="16460" checksum="27497C736794CCE4" modified="2021-09-29" version="1">MATSKVHSQRSKKLHQLSAKTTKVNRNRKAPRLYMKGTLAGYTRGLHGQTKQTALVRVENVNTREDAKWYVGKRICYVYHGKKVKRCVRWSKAPARRSTTRALWGRVTRPHGNAGMMRVKFNGASVPASAIGRRIRVYLYPSHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KD33</accession>
    <name>A0A836KD33_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Integral membrane bound transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_01550</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="loi:92357533"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="Memb_transporter_dom"/>
    </dbReference>
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    </dbReference>
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            <begin position="201"/>
            <end position="218"/>
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            <end position="746"/>
        </location>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1190" mass="132090" checksum="8316F3275B305830" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </evidence>
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        <source>
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    <sequence length="197" mass="22886" checksum="EDC7E669BAEDCECC" modified="2021-09-29" version="1">MSFTYQRMKMRATTVAVDHMRSFCDGCNLILHAVTHPFKRLVGRVKAEAPWVNTLMACTLVTALPIIFYPYVKKYVLNDERAAAEAERVRLCLQKGIDPYPYMRHKDFVYGNSAPIFADKEQIPKRIGWEFSALENYYKRKEELRQEVGGSINDTVQKLMALKKEQRSMYDSMRGKPGTEPRDLIFHGQREVNRLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG5470301.1"/>
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            <end position="217"/>
        </location>
    </feature>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="329" mass="36575" checksum="1822F679BB544D57" modified="2021-09-29" version="1">MSGDSVYALRGTSALYEVLGIPRDASQREIRQAYYRLAALYHPDKNPEGSDIFKEVCFAYGLLSDPEQRALYDSGTLRGELEVKARAYDPSMDPSVELSPEDLRVFVDRVRQSQEASRQVQSTFERRREEEMKRRAEFDAKNPSFKAEYEQARRLRQHGCGSSTSTTHAHATDTAKSLKGAPPKVRTSAEVLAELQREEEERLYGNPGVTSANSSRANVGGSGGLSTKQQMMAHYRATHSEAVAGASLSSSYNGGSATATLRRHQLQTTRLSFVREQCEKPQYSETISGTVQAYANFDYRTFVEEGSVDRGELEGAIMADALGNYDRDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KEI0</accession>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="loi:92356956"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5467870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="609" mass="65836" checksum="B95D47F676AB0BDC" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KEK7</accession>
    <name>A0A836KEK7_9TRYP</name>
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        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
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        <name evidence="2" type="ORF">LSCM4_03437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061377.1">
        <property type="nucleotide sequence ID" value="XM_067205440.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="92359374"/>
    <dbReference type="KEGG" id="loi:92359374"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5473374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="143" mass="16398" checksum="89D4C854BC7CA496" modified="2021-09-29" version="1">MRTLRGGWVHGTRVGGTALRHAYRLSSSFSSAAACSSSPSTMEKVCSNAPKTRDPFLRDGTATSRFLRAYRAQLPFPARMFGIFLIGFILGLVLEVFACKTHLYESVMMKKDARRHEFDEFVVDFRQRVERWQREDMSQRHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KEZ6</accession>
    <name>A0A836KEZ6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_02876</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060448.1">
        <property type="nucleotide sequence ID" value="XM_067204896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KEZ6"/>
    <dbReference type="SMR" id="A0A836KEZ6"/>
    <dbReference type="GeneID" id="92358830"/>
    <dbReference type="KEGG" id="loi:92358830"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434:SF11">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="5">
        <location>
            <begin position="89"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5470182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="293" mass="32735" checksum="7A40CAC5614AC46C" modified="2021-09-29" version="1">MVETKYPSKLLRFLCTVYLILSLAVQWILVWVIQVTFIVVSCPFTTSEFRQDICGHIFRKITFVGMDLLNPFWRIHVLNKFPEVKSTKVILMLNHLSGADPFVSIRSLLPRDGTWIAKGGLFRVPLGGWALYNSGDLAVHFRDKKTSFATVKGTVGPMMESARRCLRRGRMLCVFPEGIRNLNPDGPLNPFRLGFFSLAVDEGATIVPLALSGTEKLWPRGSALMDAADAYFSFGEPIDARNFKSAEELSQHVWNVITGLREKHPDRVALRARQGKAQAVSPGAPVSSSEKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KF52</accession>
    <name>A0A836KF52_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_03248</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060813.1">
        <property type="nucleotide sequence ID" value="XM_067205261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KF52"/>
    <dbReference type="GeneID" id="92359195"/>
    <dbReference type="KEGG" id="loi:92359195"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5471696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="105" mass="11767" checksum="F929246831A3149F" modified="2021-09-29" version="1">MERIVRRAARTAPSHHSLQITRERAALPCTSLSYAGTWDGPHQMDPRHPLQRIPVGHRSLSLPSGTRARGLVLDSKRAGSALRRSVHRTSSLDLPRVKESHCHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KJE3</accession>
    <name>A0A836KJE3_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061246.1">
        <property type="nucleotide sequence ID" value="XM_067204209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KJE3"/>
    <dbReference type="GeneID" id="92358143"/>
    <dbReference type="KEGG" id="loi:92358143"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008914">
        <property type="term" value="F:leucyl-tRNA--protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.70">
        <property type="entry name" value="Leucyl/phenylalanyl-tRNA-protein transferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004616">
        <property type="entry name" value="Leu/Phe-tRNA_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042203">
        <property type="entry name" value="Leu/Phe-tRNA_Trfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30098">
        <property type="entry name" value="LEUCYL/PHENYLALANYL-TRNA--PROTEIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30098:SF7">
        <property type="entry name" value="LEUCYL_PHENYLALANYL-TRNA PROTEIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5472850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="488" mass="53327" checksum="10558ED5EB4BEDA3" modified="2021-09-29" version="1">MLPPPSASGLYAAHDGAAAAKATSPPAPLACGLNWVSFVATHPFEVRAFASVLVGDDVSEEHDALVPLQLPVASMATSHKALQRAFAEVMVYPSAKAEVSRDVQHVATVWCLHPSSVYEATLSWSAKRSESVSTTTAVLRVRTEGWRVPLDLRSVAQHVLDRGSLVFHPEFTRCIFAQGAGKFMFYVPPNPLEPTTALPFMQGMWYHGLFSLPESVRIGPQSVATFFLLPNGNTRYTLDLAPESPAAPAASSTHQHDAGAAEPATSRGASAPLYPWRRQSKVRRVIRSGAYAVVARSDTAGVMASLQRARSYHRESKGSTWISDAFICLMGQCSSRSTSSSTDAAASQAAETEKPHNVRLLCIELVEKATGEVVAGCCGMAVGRAYHDYTMYTLRQSKDGFGTFLTKLIGEALQRCGYQLWYWGFCVEYMQQYERHCGAVDMPRDVFYRRWGAARDAEPECTIDAYLRSHRGMVPHYEGASGVSNSMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KKB5</accession>
    <name>A0A836KKB5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_05063</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062340.1">
        <property type="nucleotide sequence ID" value="XM_067207037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KKB5"/>
    <dbReference type="SMR" id="A0A836KKB5"/>
    <dbReference type="GeneID" id="92360971"/>
    <dbReference type="KEGG" id="loi:92360971"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000025">
        <property type="entry name" value="Glutathione peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029759">
        <property type="entry name" value="GPX_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029760">
        <property type="entry name" value="GPX_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592:SF129">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000303">
        <property type="entry name" value="Glutathion_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00460">
        <property type="entry name" value="GLUTATHIONE_PEROXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00763">
        <property type="entry name" value="GLUTATHIONE_PEROXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 5" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="12"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000303-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5476107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="182" mass="20387" checksum="4793AE25FB98850F" modified="2021-09-29" version="1">MLRVSPFRRAIGGVVSSIYDFHVNGSDHKPYDLAQHRGHPLLIYNVASKCGYTKGGYETAVTLYNKYKDRGFTVLAFPCNQFAGQEPGSEEEVKQFACTRFSAEFPIMEKVHVNGENAHPLYRYLKSACKGILGTTMVKWNFTSFLVDKDGHPVHRFSPGATANEIEKYLLPLLEVAPPSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KLA0</accession>
    <name>A0A836KLA0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lipoyl-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_05772</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063475.1">
        <property type="nucleotide sequence ID" value="XM_067207702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KLA0"/>
    <dbReference type="SMR" id="A0A836KLA0"/>
    <dbReference type="GeneID" id="92361636"/>
    <dbReference type="KEGG" id="loi:92361636"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004742">
        <property type="term" value="F:dihydrolipoyllysine-residue acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000010">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151:SF90">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="3">
        <location>
            <begin position="12"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5479764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="273" mass="27991" checksum="BC19A8097B239648" modified="2021-09-29" version="1">MMRRALLRLVNFEPVFMPALSPSMETGTVVEWKKKVGDLVKENEVFCTIQTDKAVVDYTNTFEHGYLAKIYCDNGQSAPVAKTIAVMVSNAADVEKVANYYPEDAVGGTPAAAGDSAAPPAASAAAASAAAVPACPASPAASTNHYGGSIDAAVAASGPSVSRIAAGLELSALAGIAPSGKGGRFLKSDFAGQPGFDYNDSAPERATQHKAAPARDGSKAAAKSASTAAVSGDIYNIVLKAAPVYKSVSDTPLLSKLLWSMNVPKPKANRATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KLZ5</accession>
    <name>A0A836KLZ5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glutathione-specific gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="1">4.3.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_01863</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.7" evidence="1"/>
    <dbReference type="EMBL" id="JAFHLR010000022">
        <property type="protein sequence ID" value="KAG5479271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063364.1">
        <property type="nucleotide sequence ID" value="XM_067203905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KLZ5"/>
    <dbReference type="SMR" id="A0A836KLZ5"/>
    <dbReference type="GeneID" id="92357839"/>
    <dbReference type="KEGG" id="loi:92357839"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061928">
        <property type="term" value="F:glutathione specific gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006840">
        <property type="entry name" value="ChaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12192">
        <property type="entry name" value="CATION TRANSPORT PROTEIN CHAC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12192:SF2">
        <property type="entry name" value="GLUTATHIONE-SPECIFIC GAMMA-GLUTAMYLCYCLOTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04752">
        <property type="entry name" value="ChaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5479271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="229" mass="25745" checksum="B66792BA47F49E01" modified="2021-09-29" version="1">MLSSEKLATRATRYHEELGLPSFDDHIFLIFGYGSILWKQEFEFDAEYEAYIKGYKRVFYQGSCDHRGVPGKPGRVVTLLPSEDKEERVYGKAYQLPAVPEKLNKIFQALDVREKAGYERLLVTLYDTHSSLTAGDKDHRLSLAEKGVDTHGKALVCVCYSATKDNADYLGPASMEVIARQILSSTGPSGPNREYLYNLDHALRAMGATDPHVFELAALARRLEVERPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KQD8</accession>
    <name>A0A836KQD8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_07185</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000015">
        <property type="protein sequence ID" value="KAG5482976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064472.1">
        <property type="nucleotide sequence ID" value="XM_067209089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KQD8"/>
    <dbReference type="SMR" id="A0A836KQD8"/>
    <dbReference type="GeneID" id="92363023"/>
    <dbReference type="KEGG" id="loi:92363023"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF28">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MINIBRAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="359"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="96"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="109"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="212"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="260"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5482976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="700" mass="75616" checksum="D1A8D9599ABF7EFC" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KQQ7</accession>
    <name>A0A836KQQ7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Haloacid dehalogenase-like hydrolase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_03888</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the HAD-like hydrolase superfamily. Cof family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061819.1">
        <property type="nucleotide sequence ID" value="XM_067205882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KQQ7"/>
    <dbReference type="SMR" id="A0A836KQQ7"/>
    <dbReference type="GeneID" id="92359816"/>
    <dbReference type="KEGG" id="loi:92359816"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07516">
        <property type="entry name" value="HAD_Pase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47267">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47267:SF4">
        <property type="entry name" value="PYRIDOXAL PHOSPHATE PHOSPHATASE YIGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01228">
        <property type="entry name" value="COF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01229">
        <property type="entry name" value="COF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5474713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="424" mass="46660" checksum="3AFD772B87682AA4" modified="2021-09-29" version="1">MRRPGEGLSSAIHFTPKTTACAIMTSPDNIIAANVYARKPKCVRVPAGFNPYKLVACDMDGTLLNSNHTISDYTRTVLSQLLARGVHIIFATGRPFTDVYRIKRRLNIFAAANSIPTPGFQVITPVGASPTGRYPSGSLSNSYSSGFLSSPTSTCSGAGSQGTEKIIPRCFAITSNGACIYNEANERIYERTIDPRIVQELYTMFMDDPEVNINVFRGVDEADRQQQGYTNPSDQPDDKASEEWVCRYPSDLEAALYKESRFTFRVVSNLEKTFPVDHVSEIFFLCYNPEKGFLVEADINKRMKELTQELGLTTSVRVAPSAAHCLDIVPSDVSKASALQHVLDELDLTMEDCIAFGDGLNDVELLSSVGKGCIMENGSSRLKEKLPHLEVIGRNDDDAVARKLSEIFGIEEDGCVDHPLHSHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KQU8</accession>
    <name>A0A836KQU8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit gamma</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LSCM4_04010</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061939.1">
        <property type="nucleotide sequence ID" value="XM_067206002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KQU8"/>
    <dbReference type="GeneID" id="92359936"/>
    <dbReference type="KEGG" id="loi:92359936"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03356">
        <property type="entry name" value="LbH_G1P_AT_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051960">
        <property type="entry name" value="eIF2B_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="11">
        <location>
            <begin position="14"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="12">
        <location>
            <begin position="605"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="139"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="286"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG5474833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="675" mass="71177" checksum="08AE915BE7D0D287" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KR13</accession>
    <name>A0A836KR13_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exocyst complex component EXOC2/Sec5 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_04847</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000014">
        <property type="protein sequence ID" value="KAG5483696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064635.1">
        <property type="nucleotide sequence ID" value="XM_067206826.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92360760"/>
    <dbReference type="KEGG" id="loi:92360760"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029175">
        <property type="entry name" value="EXOC2/Sec5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039481">
        <property type="entry name" value="EXOC2/Sec5_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13043:SF1">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13043">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT SEC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15469">
        <property type="entry name" value="Sec5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component EXOC2/Sec5 N-terminal" evidence="5">
        <location>
            <begin position="13"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="163"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="323"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="659"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="839"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1161"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1638"/>
            <end position="1739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1751"/>
            <end position="1835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="677"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="839"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="852"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="1167"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1191"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1658"/>
            <end position="1671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1723"/>
            <end position="1737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1774"/>
            <end position="1790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1821"/>
            <end position="1835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF15469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5483696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1835" mass="196319" checksum="8CBCA36C93D9D758" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KSX0</accession>
    <name>A0A836KSX0_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_06679</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000010">
        <property type="protein sequence ID" value="KAG5485721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065305.1">
        <property type="nucleotide sequence ID" value="XM_067208594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KSX0"/>
    <dbReference type="SMR" id="A0A836KSX0"/>
    <dbReference type="GeneID" id="92362528"/>
    <dbReference type="KEGG" id="loi:92362528"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015045">
        <property type="entry name" value="MPT-1-like_LmxM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37036">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37036:SF2">
        <property type="entry name" value="DUF1861 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08950">
        <property type="entry name" value="DUF1861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5485721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="321" mass="36098" checksum="AA9F7E59A18682CD" modified="2021-09-29" version="1">MGLLHTKPCSMIPAKEAFEREKKIYGKSILSFEGVNGYDVYNCSIPFTYNGKTYIFGRVEKNDEWVHSHTILFEKVGDNRYRRDLQSITYNLEDPFVVKIHGEMVFGGTHVTKDGGKVVDYRCEFYHGTPFNLKYFSSGPSKMKDIRLVELADGKIGVFTHFRTEGSCLTGFATIDKIEDLTVEVINSAKLINHRPFGDAWGGPSQVYLLSSGLLGCISHHGYLLDQKDDVQLRIYACTSFVFDPATYDVYDFKIIGTKGCFPPCEPKLPRLADCAFVSGIEMRDDGKCNLYSGIGDVAEGCIVIDYPFERYGKMVSDVAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KT38</accession>
    <name>A0A836KT38_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Knr4/Smi1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_04466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062659.1">
        <property type="nucleotide sequence ID" value="XM_067206450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KT38"/>
    <dbReference type="SMR" id="A0A836KT38"/>
    <dbReference type="GeneID" id="92360384"/>
    <dbReference type="KEGG" id="loi:92360384"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="528"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5477248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="559" mass="58316" checksum="2340DB76083F860F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KT83</accession>
    <name>A0A836KT83_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein ARV</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_04602</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">LSCM4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Regulates also the sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ARV1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062794.1">
        <property type="nucleotide sequence ID" value="XM_067206585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KT83"/>
    <dbReference type="GeneID" id="92360519"/>
    <dbReference type="KEGG" id="loi:92360519"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097036">
        <property type="term" value="P:regulation of plasma membrane sterol distribution"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007290">
        <property type="entry name" value="Arv1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14467">
        <property type="entry name" value="ARV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14467:SF0">
        <property type="entry name" value="PROTEIN ARV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04161">
        <property type="entry name" value="Arv1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5477383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="250" mass="28953" checksum="3EB800506EE05B72" modified="2021-09-29" version="1">MPVCTECGHGVPRIIKPDTETVERCGECGSVCDTCYELGDVQIWIDVVLLHRRAWVHVIFNRSDYYTKLVIFLLCCVLEAVVVQSLTVLEAIPFFTEDLRNSSLYTPERQVRSLQLVRIIQSSFLPLMNYPSAIWHLFIFTFTENALVASVATWLGRFFYHSYGHRARPWFVEAALASYVKLSYFLFLIWAIPPSMLPMVDFVYILWLGCAFAVLGFEHHWLYPVAIVLCCVFARVLFRYLTKWSPQVLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KTZ7</accession>
    <name>A0A836KTZ7_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000010">
        <property type="protein sequence ID" value="KAG5485587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065171.1">
        <property type="nucleotide sequence ID" value="XM_067208460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KTZ7"/>
    <dbReference type="GeneID" id="92362394"/>
    <dbReference type="KEGG" id="loi:92362394"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5485587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="246" mass="26563" checksum="4733A6104569EB88" modified="2021-09-29" version="1">MSPALWECHGRCASPLTSRPLFPSAPLPPRPLAFLHHRPFFPHHLAFPIRPIASPTALFPTIAFPSALVPPSPRVLLTASRSPHRPEPRVPPAGPTRTRTAKRVPRGGKGNPRGAAKPHRPPQGRRRRARATARSRPTAAKRTPGPAQGIIAGKRTTPSKAAGGAAPAVGASVGAQLTAGSTHPGGALDRLHFEHVGRVEKRCRHRRNAGATSSRIRSPHWAERVLERGHVKTLLPRLMRSSITFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KU43</accession>
    <name>A0A836KU43_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_07753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000006">
        <property type="protein sequence ID" value="KAG5487264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065761.1">
        <property type="nucleotide sequence ID" value="XM_067209631.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836KU43"/>
    <dbReference type="GeneID" id="92363565"/>
    <dbReference type="KEGG" id="loi:92363565"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042127">
        <property type="term" value="P:regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040266">
        <property type="entry name" value="TRNP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40714">
        <property type="entry name" value="TMF-REGULATED NUCLEAR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40714:SF1">
        <property type="entry name" value="TMF-REGULATED NUCLEAR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="762"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="864"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1613"/>
            <end position="1633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1709"/>
            <end position="1740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="771"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="864"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="874"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1717"/>
            <end position="1727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5487264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1758" mass="184778" checksum="4F0C5233CC45A661" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KVV5</accession>
    <name>A0A836KVV5_9TRYP</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_08087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000005">
        <property type="protein sequence ID" value="KAG5487642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065930.1">
        <property type="nucleotide sequence ID" value="XM_067209963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KVV5"/>
    <dbReference type="GeneID" id="92363897"/>
    <dbReference type="KEGG" id="loi:92363897"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 5"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5487642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="935" mass="100942" checksum="974D2DE6C9E3AAC4" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KWF2</accession>
    <name>A0A836KWF2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Piwi domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_05996</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000011">
        <property type="protein sequence ID" value="KAG5485360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065097.1">
        <property type="nucleotide sequence ID" value="XM_067207923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KWF2"/>
    <dbReference type="GeneID" id="92361857"/>
    <dbReference type="KEGG" id="loi:92361857"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5485360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="22321" checksum="BCF06D5B21D50BAA" modified="2021-09-29" version="1">MKNTFLEFLEEVTAHFKLQGKSTKGTVVLYRGAMTDDEAGFAENMELTVEQVLPSWDAATTVVQLRSHFRVAWDFATMLSRERHNGSSALCNVLCGLCTTDCRLIFAAANPCVPVHSFYMSSAKGSLGHASNPSYLVQKCAATISLIGPSASDVQYVLDVPSRPEALPLPLPIECAYEYGRKYSSLKAVRELPQSMRATTHHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836L259</accession>
    <name>A0A836L259_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_06821</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000009">
        <property type="protein sequence ID" value="KAG5486113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065444.1">
        <property type="nucleotide sequence ID" value="XM_067208733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836L259"/>
    <dbReference type="SMR" id="A0A836L259"/>
    <dbReference type="GeneID" id="92362667"/>
    <dbReference type="KEGG" id="loi:92362667"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF10">
        <property type="entry name" value="SLC (SOLUTE CARRIER) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="36"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="157"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="266"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5486113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="351" mass="37764" checksum="6BB140E0B72ECC35" modified="2021-09-29" version="1">MAAGKSEMAAAPGPSWPTPVWPPMKERDWALLHFIKTSLVALVPGAAQGATTVVLGHPLDTAKVRMQAAGPHTSRTTVGTMWLIAASEGPRSLYRGVAPPLLMEGIKRSLQFALWDWMRAFARDAPASRNSADGAASSGVGSAWDSACKLTHRGLVEIGNNTFMSGALVGGVGTLIGCPMHVVKIQTQYQTAADTRNAWTCMRGIYDQEGFFGFYRGFRYNVAKDVCFSGMYLGLYAMLRDQRFFKPLPANAAAATKATTAGPLRTTKARAFLAGAVASMATWALLFPLDTVKTLVQTRQPHAILATLHRPALLYRGLAASLIKAGPVSGVAMAMYEQTWGFVNKRPPPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FLP9</accession>
    <name>A0A836FLP9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glycine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Diadenosine tetraphosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_00415</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="3"/>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058598.1">
        <property type="nucleotide sequence ID" value="XM_067202497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836FLP9"/>
    <dbReference type="SMR" id="A0A836FLP9"/>
    <dbReference type="GeneID" id="92356431"/>
    <dbReference type="KEGG" id="loi:92356431"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070150">
        <property type="term" value="P:mitochondrial glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00774">
        <property type="entry name" value="GlyRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.230:FF:000001">
        <property type="entry name" value="Glycine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000004">
        <property type="entry name" value="Glycine--tRNA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000158">
        <property type="entry name" value="Glycyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033731">
        <property type="entry name" value="GlyRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003211">
        <property type="entry name" value="PRK04173.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745:SF0">
        <property type="entry name" value="GLYCINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="GLYCYL-TRNA SYNTHETASE/DNA POLYMERASE SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="10">
        <location>
            <begin position="175"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5464967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="628" mass="70388" checksum="C56CE3C0057F0163" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FRT8</accession>
    <name>A0A836FRT8_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_01099</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5468012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059814.1">
        <property type="nucleotide sequence ID" value="XM_067203164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836FRT8"/>
    <dbReference type="GeneID" id="92357098"/>
    <dbReference type="KEGG" id="loi:92357098"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007511">
        <property type="entry name" value="DUF501"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37163">
        <property type="entry name" value="CONSERVED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37163:SF1">
        <property type="entry name" value="DUF501 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04417">
        <property type="entry name" value="DUF501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5468012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="302" mass="33640" checksum="FF9D51FE3189C9EE" modified="2021-09-29" version="1">MMIERKATDDPPEAKHNAYAEAADPSRYRVADAMLFACAEHGEACVLCITAGKNGRKGRTAAVGATLFWLTCPNLNAIVARLEGHRCIQEVSKAMAQHACLCNWHVQSHDFYTSRARELLTQAQWSFFEAHFLSQEQPFMRKYGNAAVSHAADMKCLHALVAQTLAGVANPVGSITVNYILLQHQLVSEAAEIGKAELLGDDQKRCHIRATLDSTALFSSFMSAFLGAVRELRCWNWQGLRDIHFNVPLPDGSLWRKAAVQYMWRVDSQLAALLPDLCARALSVLCALEGKPPRRHKKRRIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FZE7</accession>
    <name>A0A836FZE7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cilia- and flagella-associated protein 36</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Coiled-coil domain-containing protein 104</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LSCM4_00142</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CFAP36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058332.1">
        <property type="nucleotide sequence ID" value="XM_067202231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836FZE7"/>
    <dbReference type="SMR" id="A0A836FZE7"/>
    <dbReference type="GeneID" id="92356165"/>
    <dbReference type="KEGG" id="loi:92356165"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097546">
        <property type="term" value="C:ciliary base"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1520.10">
        <property type="entry name" value="ADP-ribosylation factor-like 2-binding protein, domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023379">
        <property type="entry name" value="BART_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042541">
        <property type="entry name" value="BART_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038888">
        <property type="entry name" value="CFAP36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21532:SF0">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21532">
        <property type="entry name" value="PHOSPHODIESTERASE HL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11527">
        <property type="entry name" value="ARL2_Bind_BART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="6 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BART" evidence="12">
        <location>
            <begin position="4"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="332"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="397"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="203"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="340"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="397"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="409"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF11527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG5464701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="444" mass="48779" checksum="C0EB485109CCBD6D" modified="2021-09-29" version="1">MTDNRWITEALEQFSESPIWLTPIDNFVDDNCCIFRNDSEMQLEYTIVHKKFKELVDSLLTCFVLELGVSMEIAVGALQSSLAQSNESQDGRSDRQAAKKLLKRILNAENFLSFYTMMVKRNLELDILANAAFSSHGTDADSVGLLSGEMDGNEVSVSANVQRVRDVNGNVDDEEALRRAIEVSLQDLSTQPQVRAYSEACMHEEVDMRVAAVERQANREEAQLEATLQSLATQDLTDVERYRQENMDLIKKQKESQIQQIHSQVISGRVEKVHGEAGLPTADFGSPETPQAFPGPRSVPAAPSAPVAADVSVPALPPICHRQGALPAIPSKTAATASHPEARSSTHHEHGTAVAAQPSLAPEQVKEELERRAEYMREQREKILARNRASREEHLNTFLQNNGGETVTSSSSAESSSAAAHALTVEIARRLRGDLIGEARKSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G1Z2</accession>
    <name>A0A836G1Z2_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059226.1">
        <property type="nucleotide sequence ID" value="XM_067203535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G1Z2"/>
    <dbReference type="SMR" id="A0A836G1Z2"/>
    <dbReference type="GeneID" id="92357469"/>
    <dbReference type="KEGG" id="loi:92357469"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5466336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="380" mass="40935" checksum="6669EB6AB676D118" modified="2021-09-29" version="1">MFHASRTLSAFLPSLNFGVNKTDFFTNLWSKPQTRDERVKEYVPEVLEESLQEQRAVLEESTSRDIIVDLGNKILEAIDNKSPTPSIAPHLNRLLLEYGAKDVIAQRPLSYLLYPNSSALSAGEQAHELVSNFPDNFRAMIEEVERSGCSAKTRTPLVTTPEARSSNGTPSVAAAGHGNISGAHAYDGVATSGERESAAPSVVTPDDGKACLPSVRRADGVIMASKEEYEPMDITMFVKVAAGLAMANLHCGDTRNAVRCVDAGIAHAKEASRLGGLLGLKAGLLVRQKKFAEAADCAQLAVEASGNIQGFLHGAYALLQLNRPEEAVALLEQGRENHPMNTQFEAQIEAIQKQRRLALTATSSSPSVMKDGTQDVLPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G423</accession>
    <name>A0A836G423_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_00412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058595.1">
        <property type="nucleotide sequence ID" value="XM_067202494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G423"/>
    <dbReference type="SMR" id="A0A836G423"/>
    <dbReference type="GeneID" id="92356428"/>
    <dbReference type="KEGG" id="loi:92356428"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5464964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="131" mass="14317" checksum="E719473CAF1A757C" modified="2021-09-29" version="1">MSAAVPSQSRGPSVSSPSLAALHQLRCENAMLTEEKQFLTQAVAAGPSTSARVHSIRYHADAVELKLLRAYLIASELRDAESCRKVEMQMHQRVAEMVSKVDKLRQLLETVQKDVEEVLEASGGWSVQAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G9Z3</accession>
    <name>A0A836G9Z3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Short chain dehydrogenase/reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_05476</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5478077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062984.1">
        <property type="nucleotide sequence ID" value="XM_067207416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G9Z3"/>
    <dbReference type="GeneID" id="92361350"/>
    <dbReference type="KEGG" id="loi:92361350"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF148">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="33"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5478077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="549" mass="59025" checksum="782FA7046D308D92" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GB27</accession>
    <name>A0A836GB27_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small ribosomal subunit protein uS4 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_02730</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060305.1">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP3"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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            <end position="152"/>
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            <begin position="22"/>
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        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5470039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="226" mass="26587" checksum="92C7090DBB15837B" modified="2021-09-29" version="1">MARDTAEKKGFQAAIGMNAMKAKMESVKRSKRSKYTPPSQHSHGNPIHRPLKFHERKLLKKHDFMQYPQDNWHEPFCITKYHLEDREDYRRYMRLVGLIRQLQAQLRYLPAESKIRIQITQQLMEKLYNMGLIHEKLGLSEVDKVGVEAFCKRRLPTILRDLKMAGNCKLGADMVHHGHIRVGTTQIRDPAFLVPRGLDDYVTWMPGSKIRQHVDTFNAKRDDYNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GBV0</accession>
    <name>A0A836GBV0_9TRYP</name>
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        <recommendedName>
            <fullName evidence="2">Flagellar attachment zone protein 1 conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_02637</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060216.1">
        <property type="nucleotide sequence ID" value="XM_067204664.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92358598"/>
    <dbReference type="KEGG" id="loi:92358598"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056614">
        <property type="entry name" value="FAZ1_cons"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053285">
        <property type="entry name" value="Thylakoid_lumenal_pentapeptide"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47121">
        <property type="entry name" value="THYLAKOID LUMENAL PROTEIN TL20.3, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23398">
        <property type="entry name" value="FAZ1_cons"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flagellar attachment zone protein 1 conserved" evidence="2">
        <location>
            <begin position="38"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Flagellar attachment zone protein 1 conserved" evidence="2">
        <location>
            <begin position="196"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Flagellar attachment zone protein 1 conserved" evidence="2">
        <location>
            <begin position="352"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Flagellar attachment zone protein 1 conserved" evidence="2">
        <location>
            <begin position="512"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="Flagellar attachment zone protein 1 conserved" evidence="2">
        <location>
            <begin position="672"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="domain" description="Flagellar attachment zone protein 1 conserved" evidence="2">
        <location>
            <begin position="832"/>
            <end position="918"/>
        </location>
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    <feature type="domain" description="Flagellar attachment zone protein 1 conserved" evidence="2">
        <location>
            <begin position="990"/>
            <end position="1076"/>
        </location>
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    <feature type="domain" description="Flagellar attachment zone protein 1 conserved" evidence="2">
        <location>
            <begin position="1149"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="domain" description="Flagellar attachment zone protein 1 conserved" evidence="2">
        <location>
            <begin position="1414"/>
            <end position="1499"/>
        </location>
    </feature>
    <feature type="domain" description="Flagellar attachment zone protein 1 conserved" evidence="2">
        <location>
            <begin position="1843"/>
            <end position="1929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5469239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="2195" mass="239413" checksum="CAABFDEC5FF29E07" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GCU6</accession>
    <name>A0A836GCU6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_00263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058453.1">
        <property type="nucleotide sequence ID" value="XM_067202352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GCU6"/>
    <dbReference type="SMR" id="A0A836GCU6"/>
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    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="RBD_domain_sf"/>
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    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="230"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5464822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="272" mass="29723" checksum="3D5401A04F7FBAEF" modified="2021-09-29" version="1">MDPSKRICLKNLPEGCTKREIAELVRNRTGTPIHSIDLGVDADGQTRRYAHFSCEGAKHVLEVLNAGVVLRDSTIYAHPAKTHYSFRYAEARRKREREEAEEKEQLEAFWAASKQRFLARTNGGELPRNKTPKDFYASKRKYARIAAEIAQMSRNEHIAARASAVYVEHPRGTAHAAPFFSGADRGKYGGRSSASKNQAASDSGAAMAGEPHRTTAGSGAAHAAEKRAPQPKAAKSKAPAATTLPPPEPTKEERKLSGLQAKLAALKEKLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GD21</accession>
    <name>A0A836GD21_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NadR/Ttd14 AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_02049</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061122.1">
        <property type="nucleotide sequence ID" value="XM_067204085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GD21"/>
    <dbReference type="GeneID" id="92358019"/>
    <dbReference type="KEGG" id="loi:92358019"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070300">
        <property type="term" value="F:phosphatidic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038727">
        <property type="entry name" value="NadR/Ttd14_AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053227">
        <property type="entry name" value="TRPL-trafficking_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34932">
        <property type="entry name" value="TRPL TRANSLOCATION DEFECT PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34932:SF1">
        <property type="entry name" value="TRPL TRANSLOCATION DEFECT PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13521">
        <property type="entry name" value="AAA_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NadR/Ttd14 AAA" evidence="2">
        <location>
            <begin position="297"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="573"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="747"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="840"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="573"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="893"/>
            <end position="904"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5472726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="923" mass="97578" checksum="C0858DF8CE97D7F2" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GDI9</accession>
    <name>A0A836GDI9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CCT-theta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_00742</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058918.1">
        <property type="nucleotide sequence ID" value="XM_067202817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GDI9"/>
    <dbReference type="SMR" id="A0A836GDI9"/>
    <dbReference type="GeneID" id="92356751"/>
    <dbReference type="KEGG" id="loi:92356751"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03341">
        <property type="entry name" value="TCP1_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000008">
        <property type="entry name" value="T-complex protein 1 subunit theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012721">
        <property type="entry name" value="Chap_CCT_theta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02346">
        <property type="entry name" value="chap_CCT_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0346">Stress response</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5465287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="537" mass="58210" checksum="B179D5A9FCB26075" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GGL3</accession>
    <name>A0A836GGL3_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_03312</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060876.1">
        <property type="nucleotide sequence ID" value="XM_067205324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GGL3"/>
    <dbReference type="GeneID" id="92359258"/>
    <dbReference type="KEGG" id="loi:92359258"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF93">
        <property type="entry name" value="CORA-LIKE MG2+ TRANSPORTER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="783"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="822"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5471759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="853" mass="92447" checksum="575DF926174C09AF" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GH10</accession>
    <name>A0A836GH10_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ku domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LSCM4_03558</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061492.1">
        <property type="nucleotide sequence ID" value="XM_067205555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GH10"/>
    <dbReference type="GeneID" id="92359489"/>
    <dbReference type="KEGG" id="loi:92359489"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043564">
        <property type="term" value="C:Ku70:Ku80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00788">
        <property type="entry name" value="KU70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="DNA_bd_Ku70/Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047087">
        <property type="entry name" value="KU70_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005161">
        <property type="entry name" value="Ku_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604">
        <property type="entry name" value="KU AUTOANTIGEN DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604:SF2">
        <property type="entry name" value="X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03731">
        <property type="entry name" value="Ku_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ku" evidence="12">
        <location>
            <begin position="550"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="509"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="509"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG5473489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="930" mass="99469" checksum="2DDC23319F26E5D2" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GI01</accession>
    <name>A0A836GI01_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Actin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5468017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059819.1">
        <property type="nucleotide sequence ID" value="XM_067203169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GI01"/>
    <dbReference type="SMR" id="A0A836GI01"/>
    <dbReference type="GeneID" id="92357103"/>
    <dbReference type="KEGG" id="loi:92357103"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5468017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="423" mass="45161" checksum="96B6D1DE8E0C97AF" modified="2021-09-29" version="1">MSVVEVGTFSVRAGYIGDAACTRCIPALRAAAAPEEVDLFSLLYAASKSLDTAPLSSSSVLSNEEISGADGASMTHGGGAASSALIPLWSLRQLEGHPEAHMDSLRRLKRDVLETTEQDPLCLVLPEVWHERTDVMEALFQLILETPGLTTALYAMRPSVGWTFASGAASSIVLDVGHSHTTVTAVLDGYALRHSVDTIPVGGDAITTQYSELLSTHRPAVLSAAPALSHSTAREIHWRDWVADVKLCLAHVLPSQGGAGGVVSAGGKGSAPIAGKGAAARSATELQAPDGTRVDLDERKAALPFEVFFSAAGDGKRNVAALMALCKRRMDPEWQLHTMPHLLAGAGSLVPGFRDRMLEELKAQDSSYFRYERDRALNVTQTADGAWVGASMASSSSSFEPLWVTRGEWEEEGVSVLYRKLFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GIA1</accession>
    <name>A0A836GIA1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_02026</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061100.1">
        <property type="nucleotide sequence ID" value="XM_067204063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GIA1"/>
    <dbReference type="SMR" id="A0A836GIA1"/>
    <dbReference type="GeneID" id="92357997"/>
    <dbReference type="KEGG" id="loi:92357997"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034450">
        <property type="term" value="F:ubiquitin-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019474">
        <property type="entry name" value="Ub_conjug_fac_E4_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045132">
        <property type="entry name" value="UBE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931:SF2">
        <property type="entry name" value="UBIQUITIN CONJUGATION FACTOR E4 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931">
        <property type="entry name" value="UBIQUITINATION FACTOR E4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10408">
        <property type="entry name" value="Ufd2P_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Thioredoxin" evidence="7">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="723"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="723"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="746"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="764"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5472704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1022" mass="114757" checksum="95EE37E9F9433043" modified="2021-09-29" version="1"> </sequence>
</entry>
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            <fullName evidence="3">Uncharacterized protein</fullName>
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        <name evidence="3" type="ORF">LSCM4_00021</name>
    </gene>
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        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <location>
            <begin position="1"/>
            <end position="11"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5464583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="224" mass="25252" checksum="40C7B3F03D4870EF" modified="2021-09-29" version="1">MLLDSDGDDLPEVPTTESNSNAVVTTSVSQAQRLQQLEEDYRAKLAENAAGRQRDVRRRSSSPPLSLPAPMTPAASVWEERDEAAFYELRSLVPHLSPQFACSYTDAVLLIAAIQRGGAASGNRHTLADKCQSLEADRRQLQQRLEKSRAQCEDLKSEVADVKQKMKAMQEKSKSSVTALAQRREEMRKQLLLEEMRAEKLMVRNKKLELENDSLKERVRGQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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        <name evidence="2" type="ORF">LSCM4_03986</name>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5474809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="372" mass="41983" checksum="35DE2686AA7D3E19" modified="2021-09-29" version="1">MSVAQSADERIPLVRRAWARCVARLLPICATDTRTLSSRNFRDVSEEHFRRFIYNRYTEPQRHYHTLEHLEEMLGHLVAYEAEHGWHGAYKPAMAEEPVSSSTPPPELLTGEDSVAYEWTGMVLLLSVLFHDVVYDPTRSDNEEASAVVAAEFLETMQRESELASNSSFGAVAAVSAASPTSMAASCALPPASDGRGAEDDVSQQHPPFSYSEPPLLWVDAQATDFVRTSTMSYILKTKEHLSVEPKQPLYLTVSAGGGFTSAELRLGSDVVQQSRDDPLHVFLDLDLTILGHPDEDTYRRRYAENIRREYSHYSRADFLRGRAEFLRGFAQHPQWYRTPYFFYRLEARARHNVAHEVKALTAELAEVPVAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </evidence>
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            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5469007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="341" mass="36824" checksum="7E986C24A6E61B12" modified="2021-09-29" version="1">MSSSNDLTRGEYVNGLLVLVVAATTFVGYAGSVYWERAVAPRLFRCRESALEQEITELEREAAEICTTSNLYEHSRLMRRALRLRQELQAERRKRLAYECSVARVVSTLLDRVPFALGFGLRTGGLATAAAAPGRVSKAGTGSTQSFCADPSSTIASSSPMENDGTAYPPTAPRRRRVLGENVVNILYYNATTTVKYFLRFGSVLVLLCAFGNRRGLLAFPPSFGETLRRCAGEATVPFLLHLATYRTTALFAPGNDAPPTESRGSGATRRAADGMRGSFAKVTPPASPASLIGTDAYSSSDAGAAAMAQRLDTHVYSSGDLVSWFLACYLAVYLVQRVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GLP0</accession>
    <name>A0A836GLP0_9TRYP</name>
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        <recommendedName>
            <fullName evidence="5">Adenylyl cyclase</fullName>
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        <name evidence="3" type="ORF">LSCM4_00889</name>
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        <name type="scientific">Leishmania orientalis</name>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067202957.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92356891"/>
    <dbReference type="KEGG" id="loi:92356891"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="Nucleotide_cyclase"/>
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        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1169"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1305"/>
            <end position="1330"/>
        </location>
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    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="23"/>
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    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="89"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5467805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1330" mass="146890" checksum="F040931926511805" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GLZ4</accession>
    <name>A0A836GLZ4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059168.1">
        <property type="nucleotide sequence ID" value="XM_067203477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GLZ4"/>
    <dbReference type="SMR" id="A0A836GLZ4"/>
    <dbReference type="GeneID" id="92357411"/>
    <dbReference type="KEGG" id="loi:92357411"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07596">
        <property type="entry name" value="BAR_SNX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
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    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555:SF170">
        <property type="entry name" value="FI18122P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="1">
        <location>
            <begin position="8"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5466278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="418" mass="46783" checksum="EF495ED48FCD8DF6" modified="2021-09-29" version="1">MAASNAISVKVDVPSQVRGQGTLELSYYIYPITMRLPGFMSDARFNRRYTDFETLRSQLCATYWYCIVPPIPEKESVQEKLGRLPRMVTSAKETTASEGDLLEYRRISLRRFLQRLAYHPILGKSDLLQKFTNDNEWRQCTRDPVKPPRFISLSPLEEIARSWVPSSSSSGAGAQSSGGAAATPGGVSYTGAAYQAALTQDPVDEATWKATGEYISELESNLKNMRNLLEALVDRHRRAASAVSNFAASFGLLAEGEEDAELRSAIEGVRDCGRKVADVYSKHADNESTRLVSTLSFYVGMCSAVRETLNHMSSARQYLRNLQKKGQELQASAMRAPPASQAQVQSELHFVNEQRAHLEEDLIGAEKTFSEEFVLFHENKQYDAKDMLKKFGMLELSFSESMKQEWDALRPILESLGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GNV8</accession>
    <name>A0A836GNV8_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_02399</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059982.1">
        <property type="nucleotide sequence ID" value="XM_067204430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GNV8"/>
    <dbReference type="GeneID" id="92358364"/>
    <dbReference type="KEGG" id="loi:92358364"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040632">
        <property type="entry name" value="Sulfotransfer_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978:SF4">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOTIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17784">
        <property type="entry name" value="Sulfotransfer_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5469005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="416" mass="45851" checksum="A03BEEE3D07EE898" modified="2021-09-29" version="1">MVMLHFAGVLRKASSTTQSPPPPRLLVLTMIPNGGALSPALRTLGYHPYTFEDSVRKGRLLTHPQEWMAVLRGEKKFDFGVLAVPQPTASTAAAPSSSANSSASRTPKSATASTTLSASPPAPLFFDSMVGPPATIAFESILKECPRSTRVILVEEPDKLGWEKDMEQWLQPLVKECKKSSMWWNAPKLHMMLLDMVDLRRALIKLDSQRGGRVRSLPSSSAAMMAQNVPISKQHKMLSLSGALDLFEQHVKEVVPHDRLLVYRVRDGWQRLCDFLQVPVPMTPAAASGTPAEPVAFPPNSTGSDIFMFVHQGLRRSATVVSVLFLAVAALVVLLLGSFVVEYAQFYRDYRDYVRRDLEPYMDAEKAREGNESALTVRQALVMMKKSSKRFGEEYEMKGGATSSMASLAERVGGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GQZ6</accession>
    <name>A0A836GQZ6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tim10-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_04512</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062705.1">
        <property type="nucleotide sequence ID" value="XM_067206496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GQZ6"/>
    <dbReference type="GeneID" id="92360430"/>
    <dbReference type="KEGG" id="loi:92360430"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5477294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="102" mass="11657" checksum="8FCF9882925DB982" modified="2021-09-29" version="1">MQPVQPNPSLMGLSQSEAVILSEKLYHISNEGYMYCTKRCITHYGDDAIPYHPGEKACLDRCISKVRNGMYMAINHKKEFEEKLRSGDLPYQWMKDAATGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GR62</accession>
    <name>A0A836GR62_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063517.1">
        <property type="nucleotide sequence ID" value="XM_067207744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GR62"/>
    <dbReference type="GeneID" id="92361678"/>
    <dbReference type="KEGG" id="loi:92361678"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="628"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="757"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5479806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="983" mass="102034" checksum="5EB99E2352C2FFF3" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GRM0</accession>
    <name>A0A836GRM0_9TRYP</name>
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        <recommendedName>
            <fullName evidence="10">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_06333</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000007">
        <property type="protein sequence ID" value="KAG5486867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065661.1">
        <property type="nucleotide sequence ID" value="XM_067208256.1"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A836GRM0"/>
    <dbReference type="GeneID" id="92362190"/>
    <dbReference type="KEGG" id="loi:92362190"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="ARM-type_fold"/>
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        <property type="entry name" value="HEAT"/>
    </dbReference>
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        <property type="entry name" value="Importin-beta_N"/>
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        </location>
    </feature>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5486867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1260" mass="135596" checksum="C46A71F9C000DBF7" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GSB8</accession>
    <name>A0A836GSB8_9TRYP</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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    </gene>
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            <taxon>Trypanosomatida</taxon>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000006">
        <property type="protein sequence ID" value="KAG5487257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067209624.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="92363558"/>
    <dbReference type="KEGG" id="loi:92363558"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5487257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="320" mass="35157" checksum="342D2C10DD6813C9" modified="2021-09-29" version="1">MSYIPRSHYLIVHDALRKLLGPDAQLTAFVKAKRAFQCDMLVNDARTDPNELIRAGAQHSGGDACNDAAAKAGVEGFARALQELLGVCDVVPHTRRVDIVFRDRSLIQLALGAAKKDLPYALKTGADIDQEPDWRLRNRLRISLGYDEELFLAQCTRSVNVAARILEKCIFDAARYCALINTNAEMAAMYEASGQRWEAVLPPVTYWQAHCYALMEAYPCRHYQQIVATVEHNFALYYGEFPMTNPYCEGEDLNTIQVVKWLCEPFNAVAARAQVTSAASKMGHGVDWVLSPAMEGGGAEAAAAGIGNATDATPSQDGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GSC7</accession>
    <name>A0A836GSC7_9TRYP</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">LSCM4_07761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Discoba</taxon>
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            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
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            <taxon>Leishmania</taxon>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000006">
        <property type="protein sequence ID" value="KAG5487272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065769.1">
        <property type="nucleotide sequence ID" value="XM_067209639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GSC7"/>
    <dbReference type="GeneID" id="92363573"/>
    <dbReference type="KEGG" id="loi:92363573"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="241"/>
        </location>
    </feature>
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        <location>
            <begin position="310"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="326"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5487272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="356" mass="38338" checksum="B5061CDE775075D3" modified="2021-09-29" version="1">MVSASGTPGATAAAASAGVNREFAPHDRERDAQTRWRGYRGSYPTLGATLRQLARVFEEEQGAKQSCLSAMKTTAAAMTRGKTSGNGTSRCWGGRRGMHVATNGSHGEPSPKAAQAAVKCAALPTLRTSLDWVRYLSYVPVYPIEEALDHLEHEHDDDILLALFYSPDLFKAYNYVQWIGLMVKATCSLLRAGVLDPITRIHGDDGDADGVFSIRVPSSGSTAALRDTGTNSSSGADHRHARGQPPLFCRDLVLPLLDGILTPGDLQLMRDHTVRVAIIDACYPLWNLTRVVWRHIGRDTYDVHERYWDSESNDGDENDQHDEADATAAAETAEVPAGNGAGSGGDAGHAEGQGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GTA3</accession>
    <name>A0A836GTA3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_07460</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000004">
        <property type="protein sequence ID" value="KAG5487782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 4"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5487782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="244" mass="27929" checksum="F7F7D1103DCF3734" modified="2021-09-29" version="1">MEPATNAEYSKQEYWDRRYTEEEHYDWFPSVYPACVAASFEAVESVYRAQHRTRTFNGTLKVLHLGTGSSALCADLRAAYETKYPAEGLRPYQLVQVATDYSAVVIDHMKAKHGPPHPLADVHWVVADVRDLSRVREQFGPFFDVVLDKGTMDALQADKANEAVEDDIEQMLREVSSCVEGGVGTQVYRVFVQFTWEIPYLRLYYTTKNATHTFAWGTNVTYRFLGESDMYRVYTYEVSPPSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836GTS7_9TRYP</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
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            <taxon>Discoba</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
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                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <location>
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            <end position="13"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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            <end position="34"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="609"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5471720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="705" mass="75282" checksum="BBD5C7006178381F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GTZ2</accession>
    <name>A0A836GTZ2_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">LSCM4_00120</name>
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    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058311.1">
        <property type="nucleotide sequence ID" value="XM_067202210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GTZ2"/>
    <dbReference type="GeneID" id="92356144"/>
    <dbReference type="KEGG" id="loi:92356144"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5464680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="140" mass="15947" checksum="73AA3C4423F26335" modified="2021-09-29" version="1">MRRAACAAAVPCAQSSATLTSARTIIAAKGIVENRITKHYTNRTVEESKAERAESIKKTLHPNPRNRKEELSHLTQQCSYEYVPEFQRWANDMMAVYSDPQGYGHDMAYHYHRIWKAKSLTRRGVEDGSGAFDVCRVHPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GVH7</accession>
    <name>A0A836GVH7_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
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            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063585.1">
        <property type="nucleotide sequence ID" value="XM_067207812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GVH7"/>
    <dbReference type="SMR" id="A0A836GVH7"/>
    <dbReference type="GeneID" id="92361746"/>
    <dbReference type="KEGG" id="loi:92361746"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="202"/>
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        <location>
            <begin position="590"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5479874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="674" mass="69922" checksum="17C8C05DF9F2184B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GYF0</accession>
    <name>A0A836GYF0_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_01695</name>
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    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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        <location>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <sequence length="59" mass="6646" checksum="AED465A4BAC6232D" modified="2021-09-29" version="1">MPVSELMRTTVRASFATLQLYLCCGLLGTIRESPMLSVVVELLGRKGRKERAFLCRRTS</sequence>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Bates M.D."/>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Bates M.D."/>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33275"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17389"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.116"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:33276"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.116" evidence="14"/>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060602.1">
        <property type="nucleotide sequence ID" value="XM_067205050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H3S2"/>
    <dbReference type="GeneID" id="92358984"/>
    <dbReference type="KEGG" id="loi:92358984"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052214">
        <property type="entry name" value="DAG_Lipase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792:SF8">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="15">
        <location>
            <begin position="462"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG5470336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="801" mass="86606" checksum="8A7FDF94F7FDBEAB" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H451</accession>
    <name>A0A836H451_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_07447</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000008">
        <property type="protein sequence ID" value="KAG5486511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065577.1">
        <property type="nucleotide sequence ID" value="XM_067209334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H451"/>
    <dbReference type="GeneID" id="92363268"/>
    <dbReference type="KEGG" id="loi:92363268"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5486511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="501" mass="50894" checksum="44A201E1F94E0252" modified="2021-09-29" version="1">MPPWTHCLHLRLRTHTRAHTHANDRSAEGETIDAPLSPSLAPLLQSPHRTSLSSPLFAAAAGGRVCAACGMPLPLASLVRAATSPRAAADMATANAVTTGSSSSADCYVIVWVEGREMPVYACTAPLPFSGPSTSSSSAASAGLAAVPAVNVVALRRFFAAVALVSSSPPTAEARTDGHQEALPCATPSAVEATVLRASLPQGLVSAFGASPLYYSVAVLASSTAAAVDTELVAWLASSALAALHPDSWATTAPPDGQAHGAVLLWPPDDAPDLYSQLGEYGAAEVGRAHADAAAMENYGAREVLSDSAAQSSLAAVLEGFESCHGSPVAVAISTLLRRCWVPFTVPPPASAASVHMSLAGYFILPHTPCLAVGRSAASSLVPTLHACSGACREALFLLAAFCSRRATDLQQTSSAGTTPLAVLPLGGSSGGGGAVALVAASVGCVHPQTVLYQAVLAHCECPLRGAAAGRAAPYVHYLTTSEVAARGTLWHPGVLRSVWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H4X3</accession>
    <name>A0A836H4X3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Vacuolar protein sorting-associated protein 29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_02777</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the VPS29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060349.1">
        <property type="nucleotide sequence ID" value="XM_067204797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H4X3"/>
    <dbReference type="SMR" id="A0A836H4X3"/>
    <dbReference type="GeneID" id="92358731"/>
    <dbReference type="KEGG" id="loi:92358731"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07394">
        <property type="entry name" value="MPP_Vps29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000015">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028661">
        <property type="entry name" value="Vps29"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11124">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN VPS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="6">
        <location>
            <begin position="4"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5470083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="204" mass="22323" checksum="BADF8BAFA77F01EF" modified="2021-09-29" version="1">MVLVLVVGDTWVPQRASGIPEVFCKMFSPGRIHKLLITGSVGSKEMYDYLRTIAPEVHCVASTVDRQWTDRLPESVVLTVEGLKLGLIHGHQIAVGDKDSLAAVQRELDVDVLVSGTTHHSKYFEFDSHLFVNPGSLSGADTEYEGNVVPSFMLLDIQDKSVVTFIYQFHANDDNGGGAAANEEAVAAGMVPGLRIKKKEWVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H5D4</accession>
    <name>A0A836H5D4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Enkurin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_05292</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5477900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062807.1">
        <property type="nucleotide sequence ID" value="XM_067207239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H5D4"/>
    <dbReference type="SMR" id="A0A836H5D4"/>
    <dbReference type="GeneID" id="92361173"/>
    <dbReference type="KEGG" id="loi:92361173"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027012">
        <property type="entry name" value="Enkurin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052102">
        <property type="entry name" value="Enkurin_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21490:SF3">
        <property type="entry name" value="ENKURIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21490">
        <property type="entry name" value="ENKURIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13864">
        <property type="entry name" value="Enkurin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51665">
        <property type="entry name" value="ENKURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enkurin" evidence="7">
        <location>
            <begin position="177"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="14"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="92"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="112"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5477900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="279" mass="30612" checksum="65087E90413B7D8F" modified="2021-09-29" version="1">MSGECVYDLVADSGPSAADGLLPSAMPVTAPKKGRRAPPPTASTFGIHGTSAVVANVGGEYTGASVHPAHKPIGTFGREVASTVTPENFLRKNEGPLTASRGAPTVNNSAFKKSDCHHQKTKPDVPLRNERPVMGLRTEKNFVVANAVENTMAVPTKVMPAPRPRATDRVDFGKVPQYITEIKGDLNARKEMLEDLKAADRAAQERWSELSPSELAQLRDGLQRRWDCLNKDYQTRGFSKLETPSQRAHQELVEKQLVAVEFAMQKLSRQHVFVFDDQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H5R8</accession>
    <name>A0A836H5R8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PCIF1 WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_05495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5478095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063002.1">
        <property type="nucleotide sequence ID" value="XM_067207434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H5R8"/>
    <dbReference type="GeneID" id="92361368"/>
    <dbReference type="KEGG" id="loi:92361368"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016422">
        <property type="term" value="F:mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099122">
        <property type="term" value="F:RNA polymerase II C-terminal domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039881">
        <property type="entry name" value="PCIF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022035">
        <property type="entry name" value="PCIF1_WW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21727:SF1">
        <property type="entry name" value="PCIF1 WW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21727">
        <property type="entry name" value="PHOSPHORYLATED CTD INTERACTING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12237">
        <property type="entry name" value="PCIF1_WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="PCIF1 WW" evidence="2">
        <location>
            <begin position="272"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5478095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="578" mass="63699" checksum="799BFA55E5914D49" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H5V7</accession>
    <name>A0A836H5V7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Superoxide dismutase</fullName>
            <ecNumber evidence="2 6">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_07362</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">LSCM4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="2 6"/>
    <dbReference type="EMBL" id="JAFHLR010000008">
        <property type="protein sequence ID" value="KAG5486434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065500.1">
        <property type="nucleotide sequence ID" value="XM_067209257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H5V7"/>
    <dbReference type="SMR" id="A0A836H5V7"/>
    <dbReference type="GeneID" id="92363191"/>
    <dbReference type="KEGG" id="loi:92363191"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42769">
        <property type="entry name" value="SUPEROXIDE DISMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42769:SF12">
        <property type="entry name" value="SUPEROXIDE DISMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase N-terminal" evidence="7">
        <location>
            <begin position="34"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="8">
        <location>
            <begin position="126"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5486434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="230" mass="26100" checksum="2866C44FBFFA3750" modified="2021-09-29" version="1">MFRRVSMKAATTTAAVGASFLRYHTLPELKYPAELPKLLYAYEEGITPVFSPRQMELHYTKHHKAYVDKLNTLGKGFEGKCVEDIIEAAKSDAGRKALFNQAAQHFNHSFFWSCLTPGGRGMPEVLEAAIAKEFGTVDDFKSAFQQAGMNNFGSGWTWLCVNPKTKALEIDNTSNAGCPLTSGLRPIFTADVWEHAYYKDFENRRADYLKELWNVVNWEYVAQMFTKAMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H6C1</accession>
    <name>A0A836H6C1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Pteridine transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_06545</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Folate-biopterin transporter (TC 2.A.71) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000010">
        <property type="protein sequence ID" value="KAG5485589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065173.1">
        <property type="nucleotide sequence ID" value="XM_067208462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H6C1"/>
    <dbReference type="GeneID" id="92362396"/>
    <dbReference type="KEGG" id="loi:92362396"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039309">
        <property type="entry name" value="BT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004324">
        <property type="entry name" value="FBT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00788">
        <property type="entry name" value="fbt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31585">
        <property type="entry name" value="FOLATE-BIOPTERIN TRANSPORTER 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31585:SF51">
        <property type="entry name" value="TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03092">
        <property type="entry name" value="BT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="445"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="479"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="509"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="548"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="589"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5485589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="659" mass="71928" checksum="5FC8473FDD561E65" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H6G7</accession>
    <name>A0A836H6G7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Trypanosoma Tc-38 (p38) protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_04703</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000023">
        <property type="protein sequence ID" value="KAG5478470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063131.1">
        <property type="nucleotide sequence ID" value="XM_067206684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H6G7"/>
    <dbReference type="GeneID" id="92360618"/>
    <dbReference type="KEGG" id="loi:92360618"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045399">
        <property type="entry name" value="Tc-38"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20054">
        <property type="entry name" value="Tc-38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trypanosoma Tc-38 (p38) protein" evidence="2">
        <location>
            <begin position="335"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="511"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="649"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5478470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="818" mass="89108" checksum="0CAA2955C6BB54DD" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H824</accession>
    <name>A0A836H824_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_02074</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad17/RAD24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061147.1">
        <property type="nucleotide sequence ID" value="XM_067204110.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="92358044"/>
    <dbReference type="KEGG" id="loi:92358044"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004582">
        <property type="entry name" value="Checkpoint_prot_Rad17_Rad24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="324"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="528"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1036"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="326"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="528"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5472751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1062" mass="112438" checksum="3B0F897878BA2E41" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HAS0</accession>
    <name>A0A836HAS0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PPIase cyclophilin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5478023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062930.1">
        <property type="nucleotide sequence ID" value="XM_067207362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HAS0"/>
    <dbReference type="SMR" id="A0A836HAS0"/>
    <dbReference type="GeneID" id="92361296"/>
    <dbReference type="KEGG" id="loi:92361296"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="1">
        <location>
            <begin position="74"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5478023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="245" mass="26991" checksum="07324EDB4F896DCE" modified="2021-09-29" version="1">MFHDRIQVSSAFIHIYSFFFVHVNSHRCFAFLVLEESSLAARSAPQPTMPPRKAAAKAKLHNVEDTDIDNQNCLLRIDKGTDVYGILVIELDSGRAPRACELVAQNIPGSSTTDKSRGKQGVYKNCRFSRLTKEGIQTGEVAPAAKSVSAAELEGELGRVPHCYGSVSLCRSSTSFDGSQFFVCLTSDSVELDHLNKKYVCFGRVVEGRDVLASLQSDLSKYTEDMGVVRKDCPYLMAELSYASM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HCZ0</accession>
    <name>A0A836HCZ0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Rrp44p homologue</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LSCM4_03768</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the RNR ribonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061701.1">
        <property type="nucleotide sequence ID" value="XM_067205764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HCZ0"/>
    <dbReference type="SMR" id="A0A836HCZ0"/>
    <dbReference type="GeneID" id="92359698"/>
    <dbReference type="KEGG" id="loi:92359698"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071031">
        <property type="term" value="P:nuclear mRNA surveillance of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09862">
        <property type="entry name" value="PIN_Rrp44-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.700:FF:000007">
        <property type="entry name" value="Putative rrp44p homologue"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000126">
        <property type="entry name" value="Putative rrp44p homologue"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.690:FF:000010">
        <property type="entry name" value="Rrp44p homologue, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041505">
        <property type="entry name" value="Dis3_CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022966">
        <property type="entry name" value="RNase_II/R_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033771">
        <property type="entry name" value="Rrp44_CSD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF35">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RRP44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17849">
        <property type="entry name" value="OB_Dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17216">
        <property type="entry name" value="Rrp44_CSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01175">
        <property type="entry name" value="RIBONUCLEASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="PIN" evidence="11">
        <location>
            <begin position="60"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="RNB" evidence="12">
        <location>
            <begin position="469"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="942"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="942"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="957"/>
            <end position="971"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG5474595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="992" mass="111339" checksum="A92F00077E5BF49A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HGE5</accession>
    <name>A0A836HGE5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_05274</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062526.1">
        <property type="nucleotide sequence ID" value="XM_067207223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HGE5"/>
    <dbReference type="SMR" id="A0A836HGE5"/>
    <dbReference type="GeneID" id="92361157"/>
    <dbReference type="KEGG" id="loi:92361157"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="258"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5476293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="384" mass="42303" checksum="B52B76343BBCDD01" modified="2021-09-29" version="1">MLRRAVAHAVAPPALCRHLTVSADVREGLTKPLSSLKEECKGQNLDLADMAEAMKGATHRLQDAIQKSAVADKQFKGKVTTLSASLKAYNTRLANLQNETRSIQTEVDAVMRLLWGTERPEGANFASPPAEKVPNAAENFEVEPPLIARALGEEAPSALPKSAPPTRCVERVEGERVETMTTGTSSPADGSDKGEIEVETIDIDIEPAAQDDAVETMKVTDITKELYERGINFSDCMDARTLRQRYRDVLSGKIATTVNQSSSSASKGFTEPLTPNTSQPRMPQRASPPQHEYQYQHQQQHSSSNHTGSGITSDPYPNAHRKMVDPMKFVYQIKQELAQEKGIDASLVDLWSGKMKLDDNKRLYDYPSIQSYPIEVRQKGDVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HIK8</accession>
    <name>A0A836HIK8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Vesicle transport v-SNARE N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_04804</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VTI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000023">
        <property type="protein sequence ID" value="KAG5478571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063232.1">
        <property type="nucleotide sequence ID" value="XM_067206785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HIK8"/>
    <dbReference type="SMR" id="A0A836HIK8"/>
    <dbReference type="GeneID" id="92360719"/>
    <dbReference type="KEGG" id="loi:92360719"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000002">
        <property type="entry name" value="Vesicle transport through interaction with t-SNAREsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.400">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038407">
        <property type="entry name" value="v-SNARE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007705">
        <property type="entry name" value="Vesicle_trsprt_v-SNARE_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF26">
        <property type="entry name" value="VESICLE TRANSPORT THROUGH INTERACTION WITH T-SNARES HOMOLOG 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05008">
        <property type="entry name" value="V-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Vesicle transport v-SNARE N-terminal" evidence="11">
        <location>
            <begin position="47"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5478571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="282" mass="31044" checksum="412D5362E6BEE1F6" modified="2021-09-29" version="1">MTALLQTYEEEYRDGVRVIRDESEALRQLCDRKASGYSAPPATGPGSRVQRGAHLSTVLVQVRELVNSMEYEANDLPAAHRQTAKERIAEYRANLRTLEEGITRLKADASAADRFDLLGDAERRKAGSGGASVNQAPGDLDDATKVHRMTMLENTAKFKDASGKLQQAERLLNDTETVGNEALTNLRYQTETMQHIQGTTITVDEEVSDARKIVSGMQRMMVKHKLILISIIMILLFLICVAVYVSATKNRRNSSSSQSTEASGDPITSVAPSLLWSPSYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HJP4</accession>
    <name>A0A836HJP4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nodulin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_06004</name>
        <name evidence="8" type="ORF">LSCM4_06006</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">LSCM4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000011">
        <property type="protein sequence ID" value="KAG5485368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFHLR010000011">
        <property type="protein sequence ID" value="KAG5485370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065105.1">
        <property type="nucleotide sequence ID" value="XM_067207931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HJP4"/>
    <dbReference type="GeneID" id="92361865"/>
    <dbReference type="KEGG" id="loi:92361865"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010658">
        <property type="entry name" value="Nodulin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576:SF157">
        <property type="entry name" value="NODULIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576">
        <property type="entry name" value="UNCHARACTERIZED NODULIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06813">
        <property type="entry name" value="Nodulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="476"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="503"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="535"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="579"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="Nodulin-like" evidence="6">
        <location>
            <begin position="42"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5485368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5485370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="646" mass="71324" checksum="B7F35921EE8EFF46" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HKF1</accession>
    <name>A0A836HKF1_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_07182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000015">
        <property type="protein sequence ID" value="KAG5482973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064469.1">
        <property type="nucleotide sequence ID" value="XM_067209086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HKF1"/>
    <dbReference type="GeneID" id="92363020"/>
    <dbReference type="KEGG" id="loi:92363020"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5482973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="131" mass="14695" checksum="21CCC2C5958E567C" modified="2021-09-29" version="1">MGLETRRYIIEEDFEETFDMPLRLQSFVEFLDGVSSTTGSNTEQQHMSSNESEKSEAELFESYMGLELRLAPFNAIDANPRQCYCLDSVHCMCGDLFLPPLLIGNAAAALPQLTHDLTTRCLESNGLSNQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HKU6</accession>
    <name>A0A836HKU6_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_05824</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063527.1">
        <property type="nucleotide sequence ID" value="XM_067207754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HKU6"/>
    <dbReference type="GeneID" id="92361688"/>
    <dbReference type="KEGG" id="loi:92361688"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5479816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="490" mass="51002" checksum="9FB7E70E5369C043" modified="2021-09-29" version="1">MSLCASTGTVIAALAPSPFTLSTSLPFSKCLHTPECVRAHSKATPSSLPYRASPTRMAALPGCTLHIAVDADLSTSFAGPLCAPCTGPNCFDVPSTTPSAAPATLFPNLPSRTHVRGVRQVNAVSQTVVLHLEPSASHGDCSDSVTPAWTSSALTRNTYVVVVLDAQQVPQMLSVATARRCPPHLSGAGPLGWYLDAVVAGVQQANEEKDKPCGSDAASRWTGREMRISSNNQPCTTARTLPARRGSANGGVVHVSLFVVPNATQAVSGRNSASANATGAEAAALFSAAIAWSAARRVMLEVGDVEESLGDRSTSGAKTCRRSHAVPVELDLCTTAIHVQQATQMIAALGNKLLKAWSTSAAAASSMSLSARDTAQASMADAADVRPDTQRKVIPSDFHALYTCMLTEVTSFSERKTMAAVAAFPTMCHLLEYVDGIAASAPAAGDSSGGEGGVASQVPSAVYSTNYGEHRSWNVLNSAIIEALMTEYER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HLU7</accession>
    <name>A0A836HLU7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">UDP-glucoronosyl and UDP-glucosyl transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_04875</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000014">
        <property type="protein sequence ID" value="KAG5483723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064662.1">
        <property type="nucleotide sequence ID" value="XM_067206853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HLU7"/>
    <dbReference type="SMR" id="A0A836HLU7"/>
    <dbReference type="GeneID" id="92360787"/>
    <dbReference type="KEGG" id="loi:92360787"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF145">
        <property type="entry name" value="FI06409P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032376896" description="UDP-glucoronosyl and UDP-glucosyl transferase" evidence="5">
        <location>
            <begin position="38"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="562"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="604"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5483723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="630" mass="69011" checksum="B0D99EE39691F41B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HLV1</accession>
    <name>A0A836HLV1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7883 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_01774</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000022">
        <property type="protein sequence ID" value="KAG5479185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063278.1">
        <property type="nucleotide sequence ID" value="XM_067203819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HLV1"/>
    <dbReference type="GeneID" id="92357753"/>
    <dbReference type="KEGG" id="loi:92357753"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057205">
        <property type="entry name" value="DUF7883"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25367">
        <property type="entry name" value="DUF7883"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032795442" description="DUF7883 domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7883" evidence="3">
        <location>
            <begin position="383"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="807"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5479185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="859" mass="94851" checksum="2F6604B34264E91D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HNB1</accession>
    <name>A0A836HNB1_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_07764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000006">
        <property type="protein sequence ID" value="KAG5487275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065772.1">
        <property type="nucleotide sequence ID" value="XM_067209642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HNB1"/>
    <dbReference type="GeneID" id="92363576"/>
    <dbReference type="KEGG" id="loi:92363576"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5487275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="274" mass="29633" checksum="D96ED822CA744F92" modified="2021-09-29" version="1">MDSVFAHLSPFLFRVDQDDLDASDGAASVTEVKPLPHWLSSLAPRGEGATERSDPAAQTAKARCDGRGVDRVKRHRLDMTALMSVSAGNRYSGAARATFLPSGVMCVVWRRSLKERGVVFLGVSAAEARRDATAVDGRMANAHDTKLHRPKAPSSSVMNTYVDMTDRISCEEDMLMEGQIVDDKSGGGEVDEGYFGDVASAFGGGAFWRGGGASHQLASRSAGGGSAHQPRRRHSDDDHVRLFYHDVAVADAEEIHEGGGGRSEWRRRRPRPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HNC6</accession>
    <name>A0A836HNC6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DnaJ protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_05765</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063469.1">
        <property type="nucleotide sequence ID" value="XM_067207696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HNC6"/>
    <dbReference type="SMR" id="A0A836HNC6"/>
    <dbReference type="GeneID" id="92361630"/>
    <dbReference type="KEGG" id="loi:92361630"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000033">
        <property type="entry name" value="DnaJ family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000074">
        <property type="entry name" value="Heat shock protein DNAJ, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="6"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="8">
        <location>
            <begin position="125"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="5">
        <location>
            <begin position="125"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="376"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="385"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="412"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="440"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5479758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="454" mass="50102" checksum="5EF47A4AFE8B40AE" modified="2021-09-29" version="1">MVQDTELYEVLNVSVEADENEIKRSYRRLALKYHPDKNTGDETAADMFKKVSNAYEVLSDPEKRQLYDKYGKEGLERGMGEGGGFHDATDIFSMFFGGGARERGEPKPKDIVHELEVTLDDLYNGTTKKVMISRDRFCSTCEGSGLRPGGKRATCAQCRGRGVLLRTQQVFPGFHQQVQMRCPACGGDGEIVAAADLCTGCRGKRAVREKSVLEVHIDRGAFKSDHFTFTGEGNQQPGIRLSGDVLIFLKVRPHPVFHRVKDHLIMRCSITLQEALCGFEVPIEHLDGRELILKASPGQVVHSDSAWSVYNEGMPVKGTGGLQKGKLFVYFDVEWPETLPKKQIDQIVTALNVPEKPSKLGGQVVELREYKAAGRLKGDKGRGRSGAARAGSRAAGAGRGRGAGRNRHAYAEEDEFEDVTDDDNDGEQYGGQQYFRAGPQSFSSNTQTVECSQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HP02</accession>
    <name>A0A836HP02_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_07666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000012">
        <property type="protein sequence ID" value="KAG5484893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065005.1">
        <property type="nucleotide sequence ID" value="XM_067209545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HP02"/>
    <dbReference type="GeneID" id="92363479"/>
    <dbReference type="KEGG" id="loi:92363479"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5484893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="166" mass="19213" checksum="877E76492803612B" modified="2021-09-29" version="1">MQIILKNRNRFFAVALWSGATAVVMFWLVLRRTGFNTAYSRCTYLVMMGEYKQLLEPGTFPSNERLPPHLRLDRLSYLDLRDTEIALPPVIDVSVSDRDQVARLEDQLPATERSDLHVHFGPFQSQTIIMTTSSNERYVRRRLGLSEKDRKSLEAEGRQAVEETRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HQ13</accession>
    <name>A0A836HQ13_9TRYP</name>
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        <recommendedName>
            <fullName evidence="3">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_06071</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
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        <lineage>
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            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000011">
        <property type="protein sequence ID" value="KAG5485433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067207996.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="92361930"/>
    <dbReference type="KEGG" id="loi:92361930"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
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        <location>
            <begin position="4"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5485433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="386" mass="43296" checksum="9D109CEBDEE6A11C" modified="2021-09-29" version="1">MVQPEQHIVYAIHEYAIPGDGFLPLKAGDVVHVDEADESGWWLGTNLRGHKGIFPSTYTLPYLFPPPAEDLVEDMRLILIGHQFGMSVVSGAPQPLVPCFEADACTPAASLPPRFLLCKQMGEHLLHRETVRTKVMEMLSQLMRVRACERAERGKVAHELAAEQQHLTARLTVLRETTAALQESVLELSAQKSALLQDGAVPDSLWYEGFNNLTVEQARDSASPSQEGAWRSTLKEVQQVVKRQEEELTRLSVSCSAQEDVFTRAVTSLQARVEWRDDGVARMMAYWAAKADVVKTAYTVRKVKRDAVEEARQLEAVRLVHCLEEGQEQFLGAKQLYRQLKRHVEEIGIVLQRKESLDLLSRQIAETDGAIAAHQERQRLRSMGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HRV1</accession>
    <name>A0A836HRV1_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_07270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000015">
        <property type="protein sequence ID" value="KAG5483056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064552.1">
        <property type="nucleotide sequence ID" value="XM_067209169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HRV1"/>
    <dbReference type="GeneID" id="92363103"/>
    <dbReference type="KEGG" id="loi:92363103"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03999">
        <property type="entry name" value="MAP65_ASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="115"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="425"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="564"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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        </location>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="1206"/>
        </location>
    </feature>
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        <location>
            <begin position="239"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="359"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="446"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="564"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="666"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="698"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1090"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1147"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1184"/>
            <end position="1198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5483056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1206" mass="129238" checksum="8E8CA86BBB326975" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HT48</accession>
    <name>A0A836HT48_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Elongation of fatty acids protein</fullName>
            <ecNumber evidence="12">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LSCM4_04899</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>an acyl-CoA + malonyl-CoA + H(+) = a 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:50252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:50253"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="12"/>
    <dbReference type="EMBL" id="JAFHLR010000014">
        <property type="protein sequence ID" value="KAG5483746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064685.1">
        <property type="nucleotide sequence ID" value="XM_067206876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HT48"/>
    <dbReference type="SMR" id="A0A836HT48"/>
    <dbReference type="GeneID" id="92360810"/>
    <dbReference type="KEGG" id="loi:92360810"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030457">
        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF17">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
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                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
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                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Bates M.D."/>
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        </source>
    </evidence>
    <sequence length="319" mass="35435" checksum="A36E9C86B4C95840" modified="2021-09-29" version="1">MSFRYTNHLVATLKHRLHLEAAHRQLVRQTFTGTCDGIEVTCSAYGSVVGLRMLDRAVWEPHYRAAEDNESEAVVKAPAAASPSLPSSSSSSPSTKKGINLVRLSASIQAATWQAIQKIRAAKEEVHSRSLRRNPQLLAEARLRDWYEQDANTLHPRPCDGLKNLQATKWMQAVRFGVPKPAQHLRPNAAHEDAGEGGNRVREDPIPRATITALRDEDCDPANIPIGSVHPIFAPGLLLLELNPNAAESGGSRVDESFVLSEQRKEMRRDEEAFWERVELIRRSQLAAIPKGGAKRGYADMSATVRDSIDEKVQLRFTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836K7Z5</accession>
    <name>A0A836K7Z5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">c-Myc-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_01731</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AMY1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059469.1">
        <property type="nucleotide sequence ID" value="XM_067203778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836K7Z5"/>
    <dbReference type="SMR" id="A0A836K7Z5"/>
    <dbReference type="GeneID" id="92357712"/>
    <dbReference type="KEGG" id="loi:92357712"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026060">
        <property type="entry name" value="AMY1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13168">
        <property type="entry name" value="ASSOCIATE OF C-MYC AMY-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13168:SF0">
        <property type="entry name" value="C-MYC-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02028">
        <property type="entry name" value="CMYCBINDINGP"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5466579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="85" mass="9795" checksum="93BE1BDC769EEBF0" modified="2021-09-29" version="1">MSYRSSEAKKEEFRKYLESTQVVDALTRVLVNLYEEEEKPEDPVDYIKRVLGGASAADYEALQQENARLRAEVELLKKQLSTQAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KAE2</accession>
    <name>A0A836KAE2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_01427</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPL family. K-HECT subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059171.1">
        <property type="nucleotide sequence ID" value="XM_067203480.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92357414"/>
    <dbReference type="KEGG" id="loi:92357414"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045322">
        <property type="entry name" value="HECTD1/TRIP12-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HECTD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="8">
        <location>
            <begin position="1921"/>
            <end position="2307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="559"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1709"/>
            <end position="1782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1821"/>
            <end position="1863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2221"/>
            <end position="2244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1754"/>
            <end position="1782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1850"/>
            <end position="1863"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="2274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5466281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="2307" mass="250677" checksum="D1129F9ECAEFAFDD" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KB82</accession>
    <name>A0A836KB82_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060325.1">
        <property type="nucleotide sequence ID" value="XM_067204773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KB82"/>
    <dbReference type="SMR" id="A0A836KB82"/>
    <dbReference type="GeneID" id="92358707"/>
    <dbReference type="KEGG" id="loi:92358707"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5470059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="468" mass="51512" checksum="E7033EF96897EB37" modified="2021-09-29" version="1">MSQDASATLPTSAERPEASNSLSRNESTSSSNTSTPFESALRPGPTLWVEVWENQRWYPVIGWGTSRFLSDLPAFCFVPPARRLCGAHPADFEAAFQLANPPSPHTADPQWPARRILTVSLPAGYRWVGFWEVHREHPHGTDAAGWRYGEQFLRPLDSGVAAASTAATRQRVLTPFKKTHTRLCVVRRRLWRRRVAVMGVDDPAPSSEELLLSDAELQLQSYLSEKQEEMDMAEHLKTKEFLAAQAGEPWSQEQEMRAEEEMRKFCRERRSLESASRMRSTNPSFANPFSEWEEAYRISPADSHDDGPTKSEAQLKEQYSGAVAASSWARDSQSNRAANAVTSPTATADEARVAHNTTSLHDGCTFQTTSATSPSRVDGGDLVGQSTVQEFVASTPTDAGPWRADGADTAAQNTVDKFVASMPTDFAELSNDDQPTGVSIGGMRDPTEADFRAIFSQFITPSAGHKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KBC6</accession>
    <name>A0A836KBC6_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_00008</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the exportin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058201.1">
        <property type="nucleotide sequence ID" value="XM_067202100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KBC6"/>
    <dbReference type="SMR" id="A0A836KBC6"/>
    <dbReference type="GeneID" id="92356034"/>
    <dbReference type="KEGG" id="loi:92356034"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044189">
        <property type="entry name" value="XPO4/7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12596">
        <property type="entry name" value="EXPORTIN 4,7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12596:SF1">
        <property type="entry name" value="EXPORTIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5464570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1056" mass="115376" checksum="F536BC6EEAE88DD3" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KBE8</accession>
    <name>A0A836KBE8_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_00085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058276.1">
        <property type="nucleotide sequence ID" value="XM_067202175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KBE8"/>
    <dbReference type="SMR" id="A0A836KBE8"/>
    <dbReference type="GeneID" id="92356109"/>
    <dbReference type="KEGG" id="loi:92356109"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="522"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="140"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="247"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="537"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="551"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="581"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="606"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="621"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="638"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="665"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="689"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="735"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5464645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="886" mass="94189" checksum="CAA5E337453C8FAA" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KCQ8</accession>
    <name>A0A836KCQ8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LSCM4_03091</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">LSCM4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the vitamin-B12 independent methionine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.14" evidence="5"/>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060661.1">
        <property type="nucleotide sequence ID" value="XM_067205109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KCQ8"/>
    <dbReference type="GeneID" id="92359043"/>
    <dbReference type="KEGG" id="loi:92359043"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00082"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03312">
        <property type="entry name" value="CIMS_N_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.210:FF:000003">
        <property type="entry name" value="5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013215">
        <property type="entry name" value="Cbl-indep_Met_Synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003556">
        <property type="entry name" value="PRK05222.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30519">
        <property type="entry name" value="5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08267">
        <property type="entry name" value="Meth_synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE N-terminal" evidence="13">
        <location>
            <begin position="7"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE C-terminal/archaeal" evidence="12">
        <location>
            <begin position="440"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG5471544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="640" mass="71422" checksum="84A89EE2F90FE590" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KCY5</accession>
    <name>A0A836KCY5_9TRYP</name>
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        <recommendedName>
            <fullName evidence="2">R3H-associated N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_00912</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059629.1">
        <property type="nucleotide sequence ID" value="XM_067202979.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="92356913"/>
    <dbReference type="KEGG" id="loi:92356913"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025952">
        <property type="entry name" value="R3H-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039629">
        <property type="entry name" value="R3HDM4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32019">
        <property type="entry name" value="R3H DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32019:SF2">
        <property type="entry name" value="R3H DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13902">
        <property type="entry name" value="R3H-assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H-associated N-terminal" evidence="2">
        <location>
            <begin position="265"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="551"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="649"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="663"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5467827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="674" mass="74277" checksum="CB6CBB62CEB02AA4" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KF80</accession>
    <name>A0A836KF80_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">LSCM4_03340</name>
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        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Discoba</taxon>
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            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060903.1">
        <property type="nucleotide sequence ID" value="XM_067205351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KF80"/>
    <dbReference type="GeneID" id="92359285"/>
    <dbReference type="KEGG" id="loi:92359285"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5471786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="111" mass="11944" checksum="811EE64088001A13" modified="2021-09-29" version="1">MRCRLYPERFHSSIFFKGLDGHPTPGTAPPSPAAGRTPAAGSPCARSERYHGRWNGPRNDSASGGLPCGSREARRIWRVPHRCPTLDTGEQCTGAAALGAADGRHRIPRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KGW1</accession>
    <name>A0A836KGW1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_03716</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061649.1">
        <property type="nucleotide sequence ID" value="XM_067205712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KGW1"/>
    <dbReference type="SMR" id="A0A836KGW1"/>
    <dbReference type="GeneID" id="92359646"/>
    <dbReference type="KEGG" id="loi:92359646"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF190">
        <property type="entry name" value="MITOSIS INHIBITOR PROTEIN KINASE MIK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="30"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5473646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="318" mass="35788" checksum="595BD55F935779D0" modified="2021-09-29" version="1">MYTNDVDDAGGGQHSARRSAVAISRLTNEMSEVSEMAEGSFGVVKCYRHDFDKLEYAVKQTKRPISGESDLQQQLQEIYALSSYPHRHIVRYFDGWVEDRAVFVRLEKLDDCVASLPPPVSETVLTAMLHQTSIALYELHSHNVVHMDVKPENILRRQLDTDTFIFKLCDFGLARPLHGKDSVTGENFVGLNDDDGDRRYMSPELLKNLQDVVGPPADVYALGKSCETMMMASTEDFSTATTRQPEGYSPAFTALIESMLREDPACRPSAFQVAQATLPERLLSDRRLLDMRRRIDALRCELAEMDACDSEGVSSPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KHV7</accession>
    <name>A0A836KHV7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_03963</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Complex I functions in the transfer of electrons from NADH to the respiratory chain. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
            <orientation evidence="1 11">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the complex I NDUFA13 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061892.1">
        <property type="nucleotide sequence ID" value="XM_067205955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KHV7"/>
    <dbReference type="SMR" id="A0A836KHV7"/>
    <dbReference type="GeneID" id="92359889"/>
    <dbReference type="KEGG" id="loi:92359889"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009346">
        <property type="entry name" value="GRIM-19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12966:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12966">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE 1 ALPHA SUBCOMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06212">
        <property type="entry name" value="GRIM-19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5474786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="173" mass="20534" checksum="3A05A94BAA342788" modified="2021-09-29" version="1">MLRTTARWLVRDPVPTDTKAFYTWFSGQAYRQERVIPGGYPAVRVYPVYGKRWFTGRTVIAIVAGISIFGAWVRPERERYNMEMMIEFAERQAAHLPYQTAEVHLRCFISGYKRYRYEKENLIDKGYVGLTSEFRKFFYHSDVWRPPLHDVLMHPYVKYGGPMGSYNWSVGYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KHZ7</accession>
    <name>A0A836KHZ7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin-like fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_03566</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061500.1">
        <property type="nucleotide sequence ID" value="XM_067205563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KHZ7"/>
    <dbReference type="SMR" id="A0A836KHZ7"/>
    <dbReference type="GeneID" id="92359497"/>
    <dbReference type="KEGG" id="loi:92359497"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031397">
        <property type="term" value="P:negative regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030178">
        <property type="term" value="P:negative regulation of Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46472">
        <property type="entry name" value="NUCLEOREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46472:SF1">
        <property type="entry name" value="NUCLEOREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13905">
        <property type="entry name" value="Thioredoxin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="328"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin-like fold" evidence="3">
        <location>
            <begin position="31"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5473497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="366" mass="40648" checksum="E3B9361ABEA1A538" modified="2021-09-29" version="1">MNYFGQWSSLELVRQDGSTQLASDVLGNVPYVLLFFGASWSPECEAFMDVIGDFYEANHELKGFEVVYISRDYSRDAMMSGFLLSKRAATAAQRREDQERKEGRKHQRPHAEGDQDKKSKPAVLKEERNGTIRQHRNGQDSNGESEPRKVSSRASTSSSSTPPPLKRVVELTVSSTARSGLVSASANPISCGRRGFWAVPYDHVGCVGVPILYHLRVFTYPGVIVCRNKPFPANMTPSPLPQLPVVHSPTLPPEARPPGELETELTQAPLSPSIDPTNAPQRRQKTPKLARPEYCPDVVTVAGRFMMDQDPSGADFPWERMNSKTRRAALLFFMIVTVLAVALLSWILPILLVTRPMASLRAQANM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KI19</accession>
    <name>A0A836KI19_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">[acyl-carrier-protein] S-malonyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_01538</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>holo-[ACP] + malonyl-CoA = malonyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="EC" id="2.3.1.39"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.39" evidence="1"/>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059278.1">
        <property type="nucleotide sequence ID" value="XM_067203587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KI19"/>
    <dbReference type="SMR" id="A0A836KI19"/>
    <dbReference type="GeneID" id="92357521"/>
    <dbReference type="KEGG" id="loi:92357521"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050858">
        <property type="entry name" value="Mal-CoA-ACP_Trans/PKS_FabD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42681">
        <property type="entry name" value="MALONYL-COA-ACYL CARRIER PROTEIN TRANSACYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42681:SF1">
        <property type="entry name" value="MALONYL-COA-ACYL CARRIER PROTEIN TRANSACYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Malonyl-CoA:ACP transacylase (MAT)" evidence="5">
        <location>
            <begin position="6"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5466388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="532" mass="58883" checksum="7F0FF49453205388" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KJX6</accession>
    <name>A0A836KJX6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Guanine nucleotide-binding protein subunit beta-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_04239</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062165.1">
        <property type="nucleotide sequence ID" value="XM_067206228.1"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A836KJX6"/>
    <dbReference type="GeneID" id="92360162"/>
    <dbReference type="KEGG" id="loi:92360162"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:inner dynein arm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060294">
        <property type="term" value="P:cilium movement involved in cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036159">
        <property type="term" value="P:inner dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001782">
        <property type="entry name" value="WD_domain_-_G-beta_repeat_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF5">
        <property type="entry name" value="DYNEIN AXONEMAL INTERMEDIATE CHAIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="365"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="365"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5475657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="841" mass="93984" checksum="7A0D519793F7B7AD" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KKL9</accession>
    <name>A0A836KKL9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TBC1 domain family member 23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_02561</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060140.1">
        <property type="nucleotide sequence ID" value="XM_067204588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KKL9"/>
    <dbReference type="SMR" id="A0A836KKL9"/>
    <dbReference type="GeneID" id="92358522"/>
    <dbReference type="KEGG" id="loi:92358522"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099041">
        <property type="term" value="P:vesicle tethering to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039755">
        <property type="entry name" value="TBC1D23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13297:SF5">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13297">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 23-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="450"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="666"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="762"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="828"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="666"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="771"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5469163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="852" mass="90695" checksum="ED23AAED358F581A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KLY0</accession>
    <name>A0A836KLY0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5477907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062814.1">
        <property type="nucleotide sequence ID" value="XM_067207246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KLY0"/>
    <dbReference type="SMR" id="A0A836KLY0"/>
    <dbReference type="GeneID" id="92361180"/>
    <dbReference type="KEGG" id="loi:92361180"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003013">
        <property type="entry name" value="ATPase domain protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF196">
        <property type="entry name" value="ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="1">
        <location>
            <begin position="290"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5477907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="535" mass="57877" checksum="4CB8FE6FD36240A9" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KM69</accession>
    <name>A0A836KM69_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">vitamin-K-epoxide reductase (warfarin-sensitive)</fullName>
            <ecNumber evidence="3">1.17.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LSCM4_04299</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VKOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.4" evidence="3"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067206286.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="loi:92360220"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047057">
        <property type="term" value="F:vitamin-K-epoxide reductase (warfarin-sensitive) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042373">
        <property type="term" value="P:vitamin K metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="VKOR_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="VKOR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="VKOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038354">
        <property type="entry name" value="VKOR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042406">
        <property type="entry name" value="VKORC1/VKORC1L1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14519:SF5">
        <property type="entry name" value="VITAMIN K EPOXIDE REDUCTASE COMPLEX SUBUNIT 1-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14519">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00756">
        <property type="entry name" value="VKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0874">Quinone</keyword>
    <keyword evidence="11" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
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    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032845737" description="vitamin-K-epoxide reductase (warfarin-sensitive)" evidence="13">
        <location>
            <begin position="25"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
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        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Vitamin K epoxide reductase" evidence="14">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012278"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00756"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5475715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="163" mass="17954" checksum="F608F8FFC7163E4B" modified="2021-09-29" version="1">MFKFNLTLMGLCLVGFLLSSYAYSVEVRAERAKRLGIVYNAYCDIGPFSCTKVFSSEYGVAARFFGLPKTSIALVGLGYYMVEVLCCWHPTLILVISAPSILATVYLAFILIVVLHDLCLVCCLTYVVNVTTVFVAYRWWRRTAASKAAAAAASSSTKSKKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KNE1</accession>
    <name>A0A836KNE1_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">LSCM4_06895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000017">
        <property type="protein sequence ID" value="KAG5481819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064179.1">
        <property type="nucleotide sequence ID" value="XM_067208805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KNE1"/>
    <dbReference type="GeneID" id="92362739"/>
    <dbReference type="KEGG" id="loi:92362739"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="108"/>
        </location>
    </feature>
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        <location>
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            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="385"/>
        </location>
    </feature>
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        <location>
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            <end position="465"/>
        </location>
    </feature>
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        <location>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
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        </location>
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            <end position="12"/>
        </location>
    </feature>
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        <location>
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            <end position="37"/>
        </location>
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        <location>
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            <end position="71"/>
        </location>
    </feature>
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        <location>
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            <end position="93"/>
        </location>
    </feature>
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        <location>
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            <end position="160"/>
        </location>
    </feature>
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        <location>
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            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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        </location>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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        </location>
    </feature>
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        <location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5481819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1039" mass="107628" checksum="0B5FF9BDD7305E7E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KNG8</accession>
    <name>A0A836KNG8_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">LSCM4_06973</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000017">
        <property type="protein sequence ID" value="KAG5481894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064254.1">
        <property type="nucleotide sequence ID" value="XM_067208880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KNG8"/>
    <dbReference type="SMR" id="A0A836KNG8"/>
    <dbReference type="GeneID" id="92362814"/>
    <dbReference type="KEGG" id="loi:92362814"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044244">
        <property type="entry name" value="TTC27/Emw1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16193">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16193:SF0">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="536"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5481894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="965" mass="108416" checksum="E97AB392F2C49060" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KPA9</accession>
    <name>A0A836KPA9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sec20 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_06882</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000017">
        <property type="protein sequence ID" value="KAG5481806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064166.1">
        <property type="nucleotide sequence ID" value="XM_067208792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KPA9"/>
    <dbReference type="SMR" id="A0A836KPA9"/>
    <dbReference type="GeneID" id="92362726"/>
    <dbReference type="KEGG" id="loi:92362726"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056173">
        <property type="entry name" value="Sec20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF26">
        <property type="entry name" value="VESICLE TRANSPORT THROUGH INTERACTION WITH T-SNARES HOMOLOG 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03908">
        <property type="entry name" value="Sec20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Sec20 C-terminal" evidence="10">
        <location>
            <begin position="196"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="58"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="216"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5481806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="283" mass="30613" checksum="D3A8596D41403758" modified="2021-09-29" version="1">MTDAALYHEELLDLEQQVDAIIRAVDVSFQQAAAVAANDGGVREGGNVNSSSARAAAFTKAQDLLRRLNRLLQQLRVEMRLLDGAERDVYEAHANAHAGVVESLRVQVQQSKERAIRNTAAAGADAVAGSSPQGPRGASASGAPFRAIEGVAGVVWSPREGVDIDAEGGDGPVMSNRVEARQAATRINEMQHSTLQSLGRSEKLLNVTETLGNEAATKLRAQTEQIKQTNDMLEEMHSELGRASAELKRFMRQMARDRLIIFFAITIVVCIIIIVVLAALRHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KPI1</accession>
    <name>A0A836KPI1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Plastid-encoded RNA polymerase subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_03456</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">In plastids the minimal PEP RNA polymerase catalytic core is composed of four subunits: alpha, beta, beta', and beta''. When a (nuclear-encoded) sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061396.1">
        <property type="nucleotide sequence ID" value="XM_067205459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KPI1"/>
    <dbReference type="SMR" id="A0A836KPI1"/>
    <dbReference type="GeneID" id="92359393"/>
    <dbReference type="KEGG" id="loi:92359393"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001514">
        <property type="entry name" value="DNA-dir_RNA_pol_30-40kDasu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001988">
        <property type="entry name" value="PRK00783.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF2">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00446">
        <property type="entry name" value="RNA_POL_D_30KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="7">
        <location>
            <begin position="18"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00026088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5473393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="337" mass="37593" checksum="D690D4DAD1D94C3B" modified="2021-09-29" version="1">MRVEIIECVKKEHAAGETLTFQLNEVDSSFANALRRVMLAEVPTLAIEFVTIRQNTSVLPDEMIAHRLGLVPLFSEKAKRLNFPQDCGCGGSGCPDCQITGSLKVQCPPNQHSKQVFIGDSLHIDDAEVYPVSAEEHGIWLVTLGRSQVLDLHVIIRKNIAKTHAKFMPVATVAMRYAPEIILNPNGFQALGKAKSREWVSRCPRNVFRFVERTGQVEVQDEDACIFCRECMSQEPPFDKLPEPLVFVRQKKNKMGHFDFTFTVESTGVLPVLQIVYEAVAVVRKKLQRVSEGLMRDPNADGVMTRTIGQSTTAPVVPNADAVRKGAEEDNLDFTMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KPR3</accession>
    <name>A0A836KPR3_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_05539</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000016">
        <property type="protein sequence ID" value="KAG5482286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064292.1">
        <property type="nucleotide sequence ID" value="XM_067207478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KPR3"/>
    <dbReference type="SMR" id="A0A836KPR3"/>
    <dbReference type="GeneID" id="92361412"/>
    <dbReference type="KEGG" id="loi:92361412"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5482286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="94" mass="10813" checksum="EE53FDBDDCB65D74" modified="2021-09-29" version="1">MWRHTVRRLTFMSPGDLYALSQRSSFSSYTQYNDPCALARAYQRCSPAEKLKYQERVEAINNEIERTYQAEAQLLMQGSVDQRSNAEGAAARTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KQ02</accession>
    <name>A0A836KQ02_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD-dependent protein deacylase</fullName>
            <ecNumber evidence="5">2.3.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Regulatory protein SIR2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_04768</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>N(6)-acetyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-acetyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:43636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="ChEBI" id="CHEBI:83767"/>
            <dbReference type="EC" id="2.3.1.286"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the sirtuin family. Class II subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="5"/>
    <dbReference type="EMBL" id="JAFHLR010000023">
        <property type="protein sequence ID" value="KAG5478535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063196.1">
        <property type="nucleotide sequence ID" value="XM_067206749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KQ02"/>
    <dbReference type="SMR" id="A0A836KQ02"/>
    <dbReference type="GeneID" id="92360683"/>
    <dbReference type="KEGG" id="loi:92360683"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01967">
        <property type="entry name" value="Sirtuin_ClassII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026587">
        <property type="entry name" value="Sirtuin_class_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF10">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 5 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5 6">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="108"/>
            <end position="111"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="248"/>
            <end position="250"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="274"/>
            <end position="276"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5478535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="320" mass="35251" checksum="7C0E890F2F6DCF58" modified="2021-09-29" version="1">MRPAGALASFMERCRTGKPGRGCIVLTGAGCSTESGIPDYRGPNGRYHRDDFVPLTFQNFMRDDNEKRRYWARSMLGYSTMSGASCNASHMALQALAKSGDVAHILTQNVDGLHHLATYGGVGDVKEDHYYKYTTSDAPLTELHGNIHNVICTSCSFLMPRARLQRKLREENQALYEQYGANVLRIRPDGDYSAPTEAVNAMKLVMCPRCNGFLKPHVVLFGENVPKPVVETTMGVLREKASCLLCLGTSLHVYSAYRYVLQAKQLGMPVGIVNAGTTRADLIADLKLDVESVGSVLAETAHEMLGLPASLFFRRKTIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KQ21</accession>
    <name>A0A836KQ21_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_07007</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000018">
        <property type="protein sequence ID" value="KAG5481297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063976.1">
        <property type="nucleotide sequence ID" value="XM_067208913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KQ21"/>
    <dbReference type="GeneID" id="92362847"/>
    <dbReference type="KEGG" id="loi:92362847"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5481297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="974" mass="105813" checksum="FCADFBE4C9CB5D14" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KR38</accession>
    <name>A0A836KR38_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ADP/ATP translocase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">ADP,ATP carrier protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_04925</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the exchange of ADP and ATP across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000014">
        <property type="protein sequence ID" value="KAG5483771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064710.1">
        <property type="nucleotide sequence ID" value="XM_067206901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KR38"/>
    <dbReference type="GeneID" id="92360835"/>
    <dbReference type="KEGG" id="loi:92360835"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140021">
        <property type="term" value="P:mitochondrial ADP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990544">
        <property type="term" value="P:mitochondrial ATP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002113">
        <property type="entry name" value="ADT_euk_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635">
        <property type="entry name" value="ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635:SF10">
        <property type="entry name" value="ADP_ATP TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="284"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5483771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="376" mass="40212" checksum="403B63DB3C3990C6" modified="2021-09-29" version="1">MSAHATSPSAGHQQQQRQSPQAGSAGSDVMYGQYGGGQEFQLSAADMALDILIRAVFDLFQRSMAAPIDRVMVLTAVEGELVRQGRLPAGGFRGIKQLYGRLWRKEGLGGFLRGVVADAVLTLPSGFVDSFATNAVFVCLQRLIPAHMADQMGTPVLVALSLAATSAAVWVATPYNAIRKTIMTNYMADIVAPVGCATRAVCAGGDAAATKNSASESAGAEEAEPVSPLQEEGYRYSTATETARQIYRRKGWGGFYRGAAVEPLTVCTYRGLYLIASAMVSERVQLAYPYAVARGLAIVADILTQPLEVVSRRLVLTASDEKDDRRYAGVMDCAKTIVREEGVTALWSGLRFRLMVSVASIAIRTLFVMFTDSAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KS76</accession>
    <name>A0A836KS76_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_04848</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000014">
        <property type="protein sequence ID" value="KAG5483697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064636.1">
        <property type="nucleotide sequence ID" value="XM_067206827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KS76"/>
    <dbReference type="SMR" id="A0A836KS76"/>
    <dbReference type="GeneID" id="92360761"/>
    <dbReference type="KEGG" id="loi:92360761"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01277">
        <property type="entry name" value="HINT_subgroup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039384">
        <property type="entry name" value="HINT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648:SF1">
        <property type="entry name" value="ADENOSINE 5'-MONOPHOSPHORAMIDASE HNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="HIT FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="4">
        <location>
            <begin position="6"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="2 3">
        <location>
            <begin position="98"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="1">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5483697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="142" mass="15418" checksum="A802F2B816FD1DE9" modified="2021-09-29" version="1">MAAPCIFCKIVQGDIPCAKVAETSKAFAFMDINPLSRGHLLVIPKQHATCLHELDVESASDVGALLAKTCRAVAGRDGATQYNVLQNNGPLAHQEVPHVHFHVIPKTDTETGLRMGWNTMKVSPDELAKDAKRYSEAIEGIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KSU5</accession>
    <name>A0A836KSU5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_06603</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000010">
        <property type="protein sequence ID" value="KAG5485646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065230.1">
        <property type="nucleotide sequence ID" value="XM_067208519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KSU5"/>
    <dbReference type="SMR" id="A0A836KSU5"/>
    <dbReference type="GeneID" id="92362453"/>
    <dbReference type="KEGG" id="loi:92362453"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:001131">
        <property type="entry name" value="Zinc-binding dehydrogenase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052733">
        <property type="entry name" value="Chloroplast_QOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44013">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C16A3.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44013:SF1">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C16A3.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="59"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5485646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="478" mass="50880" checksum="437274ED31564332" modified="2021-09-29" version="1">MGSKNVANNSAAPVPPPFYVLPDVPVPPLKPSNLDFSETSGKSILCAGWIAPKGSASWSRQNVVYSSDIEIPVPQPHQVRVKMYAAGVNPADAHRTAVLPGSPEAGAGGKSCRMSRHPRPSFQFPYVIGIEGAGVVESVGWGPASRGEIDDSAGELSTADARDIRVGDRVAFLADFTQGSGGAFCQYAVVDSDIVWKLPEVVCAPPLSSTGGLVPGRLIDFVEAASLPAAAATAYLALFDKLRIETQRAIFISGASGGVGSVAVQLAHYFGLYVIASCSTPNVRYVQGLGADYVVDYTRTDVVKDILKHTDSYGVDYLLECAGASMAEAHSETVRFGGALCVLTGLLVPRSDTVFRRQLSVHYVFLGMQHQDPLARAQLQPLGELVMQLYIQGAFSVSAEQVPFVQATDALDAVASGHGRGKIVLINFHAGEDPEERQRRRHAQLYEKAQRRFQKEELQKAAGAPAADFEAVPSGVAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KTP0</accession>
    <name>A0A836KTP0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">QA-SNARE protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_06310</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000007">
        <property type="protein sequence ID" value="KAG5486844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065638.1">
        <property type="nucleotide sequence ID" value="XM_067208233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KTP0"/>
    <dbReference type="SMR" id="A0A836KTP0"/>
    <dbReference type="GeneID" id="92362167"/>
    <dbReference type="KEGG" id="loi:92362167"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000131">
        <property type="entry name" value="QA-SNARE protein putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF77">
        <property type="entry name" value="T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5486844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="27444" checksum="2946F7932216482F" modified="2021-09-29" version="1">MDSFQSTLEELDALLAMLKKKVEEVIVTYTLPEKKKVEMESRPLMREARQKLSALRAETRRTQDLDLRQSREGICKDRDETIRNFDAEMKNQIYPRRSASARPKTYQEQREEEMMGCGTADGTGFTGSKQVLNAAINVQKDALQSLQRTERLQNVAEETGKTTLAELQKQTERMYQIDEELQNLQGQLDHVARDVRWFYRQMSRDKCFLSLLGLCILALLVLVFVSIWTRRMRSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KTY7</accession>
    <name>A0A836KTY7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BCNT-C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000007">
        <property type="protein sequence ID" value="KAG5486906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065700.1">
        <property type="nucleotide sequence ID" value="XM_067208295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KTY7"/>
    <dbReference type="SMR" id="A0A836KTY7"/>
    <dbReference type="GeneID" id="92362229"/>
    <dbReference type="KEGG" id="loi:92362229"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5486906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="302" mass="33493" checksum="FD50EC685D84F6B0" modified="2021-09-29" version="1">MLASGDSASSSEASIHSSVSSSSAASFSEDDDIQDELTRTAALECLSGGHTVEAVEVTKLRMQREQRLRRVLSLRHLGQPEPIPSNTLFCTRAALSEEDTVWLYTLANRACFERLMHGIQSAAPSALAGHLDTILSRANPLFYFSYHMPVNAVSGAGDTVETSLREAPAMQRWLESTPPVLRKRPAPGHEDADESRRGADGEPVTGAFQKRPKTSASNLSAPSGLVAQSMKAWEAHLTATLTKEGETIENFRHSRTKSSYTDKKRFQEKAAWQEYVREVRMQAEQREREVKRPLRRGEVKEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KW71</accession>
    <name>A0A836KW71_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">LSCM4_08226</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sterol desaturase family. SCS7 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000003">
        <property type="protein sequence ID" value="KAG5488002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066129.1">
        <property type="nucleotide sequence ID" value="XM_067210096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KW71"/>
    <dbReference type="SMR" id="A0A836KW71"/>
    <dbReference type="GeneID" id="92364030"/>
    <dbReference type="KEGG" id="loi:92364030"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080132">
        <property type="term" value="F:fatty acid 2-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014430">
        <property type="entry name" value="Scs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863:SF1">
        <property type="entry name" value="FATTY ACID 2-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863">
        <property type="entry name" value="FATTY ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="16">
        <location>
            <begin position="42"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG5488002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="456" mass="52381" checksum="53E3FA8EBEAAF286" modified="2021-09-29" version="1">MLTTTAAAAAAPEQLNAYYTTVAATGEMIFANTGAFRAYADARRKQYESDNKHLKPAAPAPCIYMYKGSVYDATEFNVHPGGAQLMLKYHGKDVTQVFHDEYNFHAHTKSALNILLQYRVGFVRQIESSVSGERGEYENYQRLELTAYPRITNREMVYKDFTIRRDRGLVWQVMFLTFPQYMHVVSTPIYVTNCRLFDWSLIEFFSRTKYWVVLILWLPLSAFWTVRGVLRDYTQLNPLWGSRLDAFLYYPNKNFIFRNYPAAVHPSMASYIPAGATDPAVIADAQYQHAVAVSAFHPLFVLALFLSGVGLWTLMEYAIHRIIFHFERILPEPLFDNPLSKSLHLLLHGIHHIIPMDPDRLVFPPALFVVACTLIYNGFGCLMTGSCLDIMTGGLVCGYVLYDEIHYLLHHRDPTNLYFKDLKKYHHAHHYVDDTRGFGISSKFWDIVFGTACQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KX74</accession>
    <name>A0A836KX74_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_07008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000018">
        <property type="protein sequence ID" value="KAG5481298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063977.1">
        <property type="nucleotide sequence ID" value="XM_067208914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KX74"/>
    <dbReference type="GeneID" id="92362848"/>
    <dbReference type="KEGG" id="loi:92362848"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5481298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="157" mass="18780" checksum="9CB2A3778393EE4B" modified="2021-09-29" version="1">MLRRCTVFRMNRGHLAPTPSKYSDHPGMWGPGAGPVKDTLARRTMFYRMLLMNKIGRWTKPFRTNRARWIWRKTQMQLWKTFVMSMVFLCAILFGNIWLSFVYHAYTVGPTTPVLERKVREHRVSKQIMQMVRERERTMTQEEEVENARAIIESRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836L0C7</accession>
    <name>A0A836L0C7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thiamin pyrophosphokinase thiamin-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_07955</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000013">
        <property type="protein sequence ID" value="KAG5484388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064881.1">
        <property type="nucleotide sequence ID" value="XM_067209831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836L0C7"/>
    <dbReference type="GeneID" id="92363765"/>
    <dbReference type="KEGG" id="loi:92363765"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004788">
        <property type="term" value="F:thiamine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10240">
        <property type="entry name" value="Thiamin pyrophosphokinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036371">
        <property type="entry name" value="TPK_B1-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036759">
        <property type="entry name" value="TPK_catalytic_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF8">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63999">
        <property type="entry name" value="Thiamin pyrophosphokinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63862">
        <property type="entry name" value="Thiamin pyrophosphokinase, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5484388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="529" mass="56752" checksum="E4A77A9061919D5B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FPC0</accession>
    <name>A0A836FPC0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tubulin tyrosine ligase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_01694</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059432.1">
        <property type="nucleotide sequence ID" value="XM_067203741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836FPC0"/>
    <dbReference type="SMR" id="A0A836FPC0"/>
    <dbReference type="GeneID" id="92357675"/>
    <dbReference type="KEGG" id="loi:92357675"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5466542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="725" mass="80668" checksum="3B8EB951AFD0A114" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G063</accession>
    <name>A0A836G063_9TRYP</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="1" type="ORF">LSCM4_01921</name>
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        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Euglenozoa</taxon>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067203961.1"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A836G063"/>
    <dbReference type="GeneID" id="92357895"/>
    <dbReference type="KEGG" id="loi:92357895"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5472602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="240" mass="27834" checksum="0DF9281AC59F161A" modified="2021-09-29" version="1">MRRCFPRLYQAGVHTPHGTRYNAARMKNWPVQEVPQNFNFTNEQRFKAKAMPRDTGKIPRDFVLSVLYRNQPCEVSSLWEHCMSDPQIVLDSKRHLREVLQQARAEGFISFEKDAVTDRWVCHLTRERFEEVRALVGARVETLDTYSGLRGASATETSAYSEGFREMNEDAKHEHLRLLSEQVADTTAHLRKFQRMEMDYLPYTDLNGKVNFMWWYEMSDARDAAALPEAAAEGGPRLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G074</accession>
    <name>A0A836G074_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Polynucleotide kinase 3'-phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_01937</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061013.1">
        <property type="nucleotide sequence ID" value="XM_067203976.1"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A836G074"/>
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    <dbReference type="KEGG" id="loi:92357910"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
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        <property type="entry name" value="HAD-SF_hydro_IIIA"/>
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    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
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    </dbReference>
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        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE/KINASE"/>
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    </dbReference>
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        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE_KINASE"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5472617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="529" mass="57706" checksum="41C03C137CD2EA2E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G2B4</accession>
    <name>A0A836G2B4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_01683</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059421.1">
        <property type="nucleotide sequence ID" value="XM_067203730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G2B4"/>
    <dbReference type="GeneID" id="92357664"/>
    <dbReference type="KEGG" id="loi:92357664"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="6">
        <location>
            <begin position="13"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="5">
        <location>
            <begin position="46"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="5">
        <location>
            <begin position="273"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5466531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="386" mass="43455" checksum="1BAA99908AF2E4D5" modified="2021-09-29" version="1">MESPEVENNVVPAADEWVCSNCEVQQTAEATFCQMCRFARPLDRHGVPQIFSGYSFHFNGIIPRTIMHPSHSVEWRMAERHGATCCASFDPSVVTILIYRPGYERSEKCRACIENHTNIPCVPIAWMMDSLLQSRQIHPSLYRLKSVPPVANPTGGGANLPHHQHPFYQMNKFEYSIPTSFPTSKAKAVKAVRVREGVSYKSLDVPAGMEEAIPPFFEIEPYHYTTLDVCDAVLKCDARTTADAGYDENDEVEARRKKTGIELIVMMQSLNRVDRMLFSGMSLLLTPSLQRHEGLKKAIERCGGKLVTKTASVDEALQDDLTHILYVMEDQQCSLMVEAAKLINTSLPGLQLVEYKWVEDCLILGELLPFHGMYTPSPQLMKILSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G3X0</accession>
    <name>A0A836G3X0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_00318</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058505.1">
        <property type="nucleotide sequence ID" value="XM_067202404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G3X0"/>
    <dbReference type="SMR" id="A0A836G3X0"/>
    <dbReference type="GeneID" id="92356338"/>
    <dbReference type="KEGG" id="loi:92356338"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051831">
        <property type="entry name" value="Bromodomain_contain_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22881:SF27">
        <property type="entry name" value="BROMODOMAIN CONTAINING 7_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22881">
        <property type="entry name" value="BROMODOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="5">
        <location>
            <begin position="24"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="169"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="170"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="192"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5464874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="236" mass="26518" checksum="C48261CA467A8C7B" modified="2021-09-29" version="1">MGGGKHPREGFHKEQCLSFVSKLWAADTLSMFHHPVSATEVPGYYDVVEAPMDLSTIRKKIEEDRYSADAEVENDVALMLSNALEFNEKDSQWYNLAKQLKKRYLLLAQESGLSFDADRVFIPTKKVRDDESTLRKAEEEVDEKIEDVLEAMEKDKEIPLEQLRAMYARRKGEGMTDQHSSDHGSGRVSVSSDEEVSSDEENTSDDSSSGGSDETSEEDEEASSDSQTASRDDDNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G480</accession>
    <name>A0A836G480_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Guanine nucleotide-binding protein subunit beta-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_00506</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat WDR55 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058685.1">
        <property type="nucleotide sequence ID" value="XM_067202584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G480"/>
    <dbReference type="GeneID" id="92356518"/>
    <dbReference type="KEGG" id="loi:92356518"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:002613">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050505">
        <property type="entry name" value="WDR55/POC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019:SF20">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="188"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="466"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="537"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="466"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="496"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="509"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="571"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="638"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5465054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="725" mass="79891" checksum="7961B023FF015F11" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G682</accession>
    <name>A0A836G682_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">fumarate reductase (NADH)</fullName>
            <ecNumber evidence="6">1.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">NADH-dependent fumarate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_01291</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>succinate + NAD(+) = fumarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18281"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.3.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.6" evidence="6"/>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059039.1">
        <property type="nucleotide sequence ID" value="XM_067203348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G682"/>
    <dbReference type="SMR" id="A0A836G682"/>
    <dbReference type="GeneID" id="92357282"/>
    <dbReference type="KEGG" id="loi:92357282"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016156">
        <property type="term" value="F:fumarate reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000007">
        <property type="entry name" value="NADH-dependent fumarate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050315">
        <property type="entry name" value="FAD-oxidoreductase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010960">
        <property type="entry name" value="Flavocytochrome_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01813">
        <property type="entry name" value="flavo_cyto_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400:SF7">
        <property type="entry name" value="FAD-DEPENDENT OXIDOREDUCTASE 2 FAD BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="10">
        <location>
            <begin position="147"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="100"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="118"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00050832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00077246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5466149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="631" mass="66709" checksum="08E8D55075AB95CB" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G6S5</accession>
    <name>A0A836G6S5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Diphthamide biosynthesis protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_05273</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2 [3Fe-4S](0)-[protein] + 2 Fe(2+)-[Dph3] + NADH = 2 [4Fe-4S](1+)-[protein] + 2 [Dph3] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:71239"/>
            <dbReference type="Rhea" id="RHEA-COMP:17997"/>
            <dbReference type="Rhea" id="RHEA-COMP:17998"/>
            <dbReference type="Rhea" id="RHEA-COMP:18001"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:33723"/>
            <dbReference type="ChEBI" id="CHEBI:47402"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[3Fe-4S](1+)-[protein] + Fe(2+)-[Dph3] = [3Fe-4S](0)-[protein] + Fe(3+)-[Dph3]</text>
            <dbReference type="Rhea" id="RHEA:71235"/>
            <dbReference type="Rhea" id="RHEA-COMP:17996"/>
            <dbReference type="Rhea" id="RHEA-COMP:17997"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="Rhea" id="RHEA-COMP:18003"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:33751"/>
            <dbReference type="ChEBI" id="CHEBI:47402"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DPH3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062525.1">
        <property type="nucleotide sequence ID" value="XM_067207222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G6S5"/>
    <dbReference type="SMR" id="A0A836G6S5"/>
    <dbReference type="GeneID" id="92361156"/>
    <dbReference type="KEGG" id="loi:92361156"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.660.10:FF:000008">
        <property type="entry name" value="CSL zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.660.10">
        <property type="entry name" value="DPH Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044248">
        <property type="entry name" value="DPH3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007872">
        <property type="entry name" value="DPH_MB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036671">
        <property type="entry name" value="DPH_MB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454:SF31">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454">
        <property type="entry name" value="DPH3 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05207">
        <property type="entry name" value="Zn_ribbon_CSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144217">
        <property type="entry name" value="CSL zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51074">
        <property type="entry name" value="DPH_MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DPH-type MB" evidence="8">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5476292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="80" mass="8910" checksum="552A2B177416BC77" modified="2021-09-29" version="1">MEEFHYEEVQLSEMTLEDGMLRFPCPCGDLFELLLQDFIAGSDVAQCPTCSLTIKVIFTKDEKNDFLARNSVTAVCAVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G8M2</accession>
    <name>A0A836G8M2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_04576</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062768.1">
        <property type="nucleotide sequence ID" value="XM_067206559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G8M2"/>
    <dbReference type="SMR" id="A0A836G8M2"/>
    <dbReference type="GeneID" id="92360493"/>
    <dbReference type="KEGG" id="loi:92360493"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="145"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5477357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="293" mass="33887" checksum="04862E624F391B6C" modified="2021-09-29" version="1">MKFGASLFSKCVPLSCSGANVSDLLHLLDAFLNYFYTSDCFALRKQISLIALFGRAAMRRSLALLLHSSSACLLSARKLSQYEQEAYESHRRFTESRTYPGSIRAATPGDTRFYMGSVETILQENERHYWRAVVDDPQVQYLVPLRIRFKTFTWVTSGWEQRMQVVQVMVQRDATVAELLQQVRIENQSPYLCTSSFKLSIDGKELDEQKTLVDYCIDEYSRIDAIEEKDHLLHTEAERPKDWNVDEMTEELLLRSPYKEMGMQPQRNLAPRYEAKPKGYHGKNDYSGMKQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G9I9</accession>
    <name>A0A836G9I9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Programmed cell death protein 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_01081</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465152.1"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5465152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="238" mass="26927" checksum="60DAE66C17A96473" modified="2021-09-29" version="1">MSHYNTGIGSNVPSLFDLSSGLTAFLVDFIQVLLGQTQTSFQAAAPEDSNPGVYDPDTRSWSGPDGLRYRVPLFPIPSERHTREKVRNVKLLMDNCRRICLSDELPATREEKRFWAAYRFMQYQLFLAPACVVTPPVYVFFKVFHGNLPRFLRGRTVPLMTGLAIAELWAEATYPGHQLLSTALRAKTPMGDAARAEWTRLQPIDIPFYIFTSYQFQQLFNSVPEEYLFGGDLASLCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GDF9</accession>
    <name>A0A836GDF9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein yippee-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_02277</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the yippee family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061347.1">
        <property type="nucleotide sequence ID" value="XM_067204310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GDF9"/>
    <dbReference type="GeneID" id="92358244"/>
    <dbReference type="KEGG" id="loi:92358244"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034751">
        <property type="entry name" value="Yippee"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004910">
        <property type="entry name" value="Yippee/Mis18/Cereblon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039058">
        <property type="entry name" value="Yippee_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13848">
        <property type="entry name" value="PROTEIN YIPPEE-LIKE CG15309-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03226">
        <property type="entry name" value="Yippee-Mis18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51792">
        <property type="entry name" value="YIPPEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Yippee" evidence="5">
        <location>
            <begin position="17"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU110713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5472951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="140" mass="15827" checksum="E7A0594E8071CE45" modified="2021-09-29" version="1">MVKRLRTRLAAPSGGEGGFGCAFCGAHLCVAEDIVSDNFRGRHGKAFLVSRCENTYYGHQEEKQLMTGLHRVRDVFCSNCDQYVGWGYDFAVDEREMYKMQRFVLERQLIRVITHGQLRGALGYSIPEANVTFSLPVARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GDG9</accession>
    <name>A0A836GDG9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP synthase F1 complex delta/epsilon subunit N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_02292</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061362.1">
        <property type="nucleotide sequence ID" value="XM_067204325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GDG9"/>
    <dbReference type="SMR" id="A0A836GDG9"/>
    <dbReference type="GeneID" id="92358259"/>
    <dbReference type="KEGG" id="loi:92358259"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.15.10:FF:000014">
        <property type="entry name" value="ATP synthase, epsilon chain, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="entry name" value="F0F1 ATP synthase delta/epsilon subunit, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822">
        <property type="entry name" value="ATP SYNTHASE DELTA/EPSILON CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822:SF7">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT DELTA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="Epsilon subunit of F1F0-ATP synthase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP synthase F1 complex delta/epsilon subunit N-terminal" evidence="10">
        <location>
            <begin position="49"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5472966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="181" mass="19991" checksum="D589230C667A7039" modified="2021-09-29" version="1">MFRSCGRRLVARTLTLLADHQEVPEAFEFMEHKVVDKDIHAAYENMETLRLTLTRQDEFLFKETPVKCVTIMGVNGENGVYPGHAYEITQLAPAPLSVEMTDGTVNKFFASGGFAHINNEGSCDINCVECIPLAELDADAAEKALAQQQSALNSAHDEKAKAVIEIRISVLESVIQALKHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GE47</accession>
    <name>A0A836GE47_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_03381</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060941.1">
        <property type="nucleotide sequence ID" value="XM_067205389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GE47"/>
    <dbReference type="SMR" id="A0A836GE47"/>
    <dbReference type="GeneID" id="92359323"/>
    <dbReference type="KEGG" id="loi:92359323"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="173"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="235"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5471824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="522" mass="56171" checksum="A40AB7B87CC7FAA3" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GF43</accession>
    <name>A0A836GF43_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">USP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_01423</name>
    </gene>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
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                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Bates M.D."/>
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                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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                <person name="Bates M.D."/>
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                <person name="Bates M.D."/>
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                <person name="Bates M.D."/>
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                <person name="Urbaniak M.D."/>
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                <person name="Jariyapan N."/>
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                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000014">
        <property type="protein sequence ID" value="KAG5483807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064746.1">
        <property type="nucleotide sequence ID" value="XM_067206937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GKQ6"/>
    <dbReference type="SMR" id="A0A836GKQ6"/>
    <dbReference type="GeneID" id="92360871"/>
    <dbReference type="KEGG" id="loi:92360871"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06606">
        <property type="entry name" value="STKc_MAPKKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF56">
        <property type="entry name" value="MAPKK KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="455"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="66"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="228"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="811"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="988"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1064"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="244"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="824"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="836"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="855"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="886"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1082"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="484"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5483807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1097" mass="114380" checksum="02386BE928851BAE" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GLL3</accession>
    <name>A0A836GLL3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_00840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059562.1">
        <property type="nucleotide sequence ID" value="XM_067202912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GLL3"/>
    <dbReference type="GeneID" id="92356846"/>
    <dbReference type="KEGG" id="loi:92356846"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5467760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="470" mass="52909" checksum="9B111CCED13A0845" modified="2021-09-29" version="1">MSQFGRPHSPYDWGAGVRVRVQRACQAPYFSVFREENTRQADAVYEGRLGRAGTGAYPTIQDDGQRLLYFPYRNAEPVHCSVAEAAGVASEAVTLIGATGTVGKFVAEQYLRRGVSVTVMARDIEKAKSLFLPIVDGQSERSRLAATGLMQLGSAADRRELTASLDYRDSQREDRRVLRYEFRTSQSVEGPSADRADASRDHHVVLELIEGDVGSTEDLEFSMRHASVVFYLAAALEEASGMALWTDGRPGLSAAWWSPRSWFGRGRRFGGFLHALDACRRVDAHFVALTPLWVHGSRLSPFYWYRRIVTYPRGYCKAVRLQEQTLLSQCGSPSVRCCFGTDELEEQHLGGDWWYWWRIWFSTELPEDCSAKSRSPVRFSLFRLSDIVFPSLNERIVAAKNNRVDNNIHIESIQHGSLDARLLANVLVKAIALCNSVVESRIDIGGRLRDGTSMRDASAVFDLFERFRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GLN1</accession>
    <name>A0A836GLN1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LSCM4_07853</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">LSCM4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-13 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000013">
        <property type="protein sequence ID" value="KAG5484287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064780.1">
        <property type="nucleotide sequence ID" value="XM_067209730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GLN1"/>
    <dbReference type="SMR" id="A0A836GLN1"/>
    <dbReference type="GeneID" id="92363664"/>
    <dbReference type="KEGG" id="loi:92363664"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007019">
        <property type="term" value="P:microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01367">
        <property type="entry name" value="KISc_KIF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000012">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001293">
        <property type="entry name" value="Znf_TRAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47971:SF4">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47971">
        <property type="entry name" value="KINESIN-RELATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02176">
        <property type="entry name" value="zf-TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50145">
        <property type="entry name" value="ZF_TRAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 10 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="352"/>
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        </location>
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        <location>
            <begin position="429"/>
            <end position="471"/>
        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50145"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5484287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="723" mass="79194" checksum="75E4C69D23C2C948" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GNN9</accession>
    <name>A0A836GNN9_9TRYP</name>
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        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="4" type="ORF">LSCM4_05940</name>
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        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
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    </organism>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG5485307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <location>
            <begin position="94"/>
            <end position="150"/>
        </location>
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        <location>
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    <feature type="coiled-coil region" evidence="1">
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            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5485307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="10">Helicase-like protein</fullName>
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        <name evidence="8" type="ORF">LSCM4_04563</name>
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        <name type="scientific">Leishmania orientalis</name>
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        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="DEXHc_Snf"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
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        <property type="entry name" value="Znf_PHD"/>
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    <dbReference type="InterPro" id="IPR013083">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HELICASE_CTER"/>
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    <proteinExistence type="predicted"/>
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            <end position="467"/>
        </location>
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            <end position="53"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="806"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5477344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1008" mass="110052" checksum="D6A0A71336F1C7A9" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GQ40</accession>
    <name>A0A836GQ40_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_00984</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
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                <person name="Al-Salem W.S."/>
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                <person name="Bates M.D."/>
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    <sequence length="375" mass="41670" checksum="4B02546431B01D2C" modified="2021-09-29" version="1">MHTSAPACSDVLVTLPATELRESLANILVAIDASERSCVEEGKALEAQRQRVLGLLSKLDVMNDLYKTPDTIEPRKGVLISPSCAETNDEGLGLLDASPNSSEKAHARSQIAREPLREAVADAGDVPTTLVSHPNHRCLLGNLFSQPRRSYTAASLDTSFCCVSSPPPRWSVEEGWSNGRYESNLDRCAAATVSRQLGHFCCSPERELSPSHHGRASACERYNVPSSLLRHRHETENYPKRRQPSLCTPSVQLSAQRSRRWSSDAKLPCSFWINVWPCLGGTVASRARRPTRVLVQGRCRYFEDVLEKAAKLTNCQPAPHCFYTPDGCLIRYLEDLIAEHHYLLFSSGGLYRRESVPTALLWLLYTDARHIVACS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <evidence type="ECO:0000256" key="1">
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    <sequence length="123" mass="15084" checksum="F39F3A8F8AFA8741" modified="2021-09-29" version="1">MGSPYEYQPEVKWYHVLWDLRNKEFRQWFLRKKYRDMRMAYKYESHILYQKAGMGFLMAAVFMSIFSSDLAVAVFRWPTEDPNELLKSQVWQKYHNQVNERKEYADKLLQDSNYMHKKNNPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836GS81_9TRYP</name>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5477999.1"/>
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        </source>
    </evidence>
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        <source>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="3">Proteasome maturation factor UMP1</fullName>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG5480856.1"/>
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    <dbReference type="KEGG" id="loi:92362279"/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="13936" checksum="5EBB0F3646D1FC93" modified="2021-09-29" version="1">MSKEIGLPRPQAREERLMHPVEFIQRSAPRQEEALRMHNIRTTHGLGAATEVALTEVTLLGSRRLGALPSSNTLYNSYRGNFTELNPSDMYGLPENDPNVQPAPRAFVEKQFHGHELTMKTLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836GTF3_9TRYP</name>
    <protein>
        <recommendedName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_00121</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Endoplasmic reticulum membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyltransferase 22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="8"/>
    <dbReference type="EMBL" id="JAFHLR010000036">
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        <property type="nucleotide sequence ID" value="XM_067202211.1"/>
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    <dbReference type="GeneID" id="92356145"/>
    <dbReference type="KEGG" id="loi:92356145"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Glyco_transf_22"/>
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    </dbReference>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="156"/>
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            <end position="226"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="267"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5464681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="624" mass="71549" checksum="63EE130FD1DBA602" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GUB5</accession>
    <name>A0A836GUB5_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG5470028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5470028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="582" mass="63567" checksum="F7F235A073274D99" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GWX8</accession>
    <name>A0A836GWX8_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01461</name>
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    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
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        <lineage>
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            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067203514.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="92357448"/>
    <dbReference type="KEGG" id="loi:92357448"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
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    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
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    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5466315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1318" mass="142547" checksum="750757765C9176BB" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GX98</accession>
    <name>A0A836GX98_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059385.1">
        <property type="nucleotide sequence ID" value="XM_067203694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GX98"/>
    <dbReference type="GeneID" id="92357628"/>
    <dbReference type="KEGG" id="loi:92357628"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5466495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="331" mass="37284" checksum="7197627EF38D6A02" modified="2021-09-29" version="1">MRVYSSLRGPLQACHLMPCPAARALQPCCRHRNYGSTRKIWPNASLSDCVSGLHSCASACIGSVLSRRAASSPLFATPRWRSSRRNFTRSSLRFCWRCAGRTSLLCSCAISCSTVGPCTVISVAWPRRPIRYPTQRDGAELHMKKTEMSLFEVIFLFFFSPQPRALVHLFSRILAFDTHTHTHIHICVYVCMPARVKPQKKKRAGAKAMTGKRHNLLLQTARIPCHRFIMDHQSLYAMTHVPTRFPDVHHHPEPSQQRSCSKHAPSRALLAAPSHLSLCRRRPLWGNAKKNASLSLPSPPPPPRLPLTSPLFASFFVGGQWPDRVVRINDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GZN2</accession>
    <name>A0A836GZN2_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_00773</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059497.1">
        <property type="nucleotide sequence ID" value="XM_067202847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GZN2"/>
    <dbReference type="GeneID" id="92356781"/>
    <dbReference type="KEGG" id="loi:92356781"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5467695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="70" mass="7425" checksum="9F41550BE7ED0993" modified="2021-09-29" version="1">MCSSGACASEPRTREGSEGVLCAARALRIPRGLGLHEQRALGSYGGAVKGAKRSECKLRLLARVATRRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GZR9</accession>
    <name>A0A836GZR9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alkyl transferase</fullName>
            <ecNumber evidence="3">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_07842</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">LSCM4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the UPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="3"/>
    <dbReference type="EMBL" id="JAFHLR010000013">
        <property type="protein sequence ID" value="KAG5484276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064769.1">
        <property type="nucleotide sequence ID" value="XM_067209719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GZR9"/>
    <dbReference type="SMR" id="A0A836GZR9"/>
    <dbReference type="GeneID" id="92363653"/>
    <dbReference type="KEGG" id="loi:92363653"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045547">
        <property type="term" value="F:ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016094">
        <property type="term" value="P:polyprenol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1180.10:FF:000019">
        <property type="entry name" value="Alkyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="entry name" value="Decaprenyl diphosphate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291:SF43">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT DHDDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="Undecaprenyl diphosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5484276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="386" mass="43151" checksum="5B2F1AA54843F9AA" modified="2021-09-29" version="1">MGALPQLRPGATPAQRGVSPVLNGSDDISTLRTACGTFGMMCLSVLVFAFLGQIALALLKLYTRGGAPRATKTITVDRPHHIARHVRHLGIIMDGNRRYGRRHSRAGSDPDAAALREIREELCSAAKVTAANGESGESSWLAARYHRFADIIQHTSLDGHRVGGEKLLEVINHCMEANIGMVTVYAFSTDNWNRPTAEVDALLSLFFFFFSRVHKVALDRHIFVRFITTEPYRLPPRVVELMRSVEGETRVMLPRRLVLNICVSYSGQSEVVAACNRLLARRLLHSSDPVAVATEVTKAELDREMLRSITQDEHEAEDAQIFGDDISVEPDLILRTSGEQRISNFLLYECAYSELIFLDKAWPEVTEGDIHQALSDFARRDRRNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H0Z3</accession>
    <name>A0A836H0Z3_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_04157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062083.1">
        <property type="nucleotide sequence ID" value="XM_067206146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H0Z3"/>
    <dbReference type="GeneID" id="92360080"/>
    <dbReference type="KEGG" id="loi:92360080"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="543"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="545"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="580"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5475575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="593" mass="64800" checksum="21ECCAD3B549C063" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H2F9</accession>
    <name>A0A836H2F9_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_02532</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060112.1">
        <property type="nucleotide sequence ID" value="XM_067204560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H2F9"/>
    <dbReference type="GeneID" id="92358494"/>
    <dbReference type="KEGG" id="loi:92358494"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5469135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="116" mass="13040" checksum="683DCD120E0C0332" modified="2021-09-29" version="1">MFRRLGLQVATRSGAARSGARTYFYANCGETGISGATMQTLLKVTLACCVVQVFAIRHYVFDRLGTKKQFLEDSTDLWENDGTEMEGEEAVANLRIQHERIMPFMNDIKDKLDAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H2X6</accession>
    <name>A0A836H2X6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">5-formyltetrahydrofolate cyclo-ligase</fullName>
            <ecNumber evidence="5">6.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_04750</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP = (6R)-5,10-methenyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10488"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.2" evidence="5"/>
    <dbReference type="EMBL" id="JAFHLR010000023">
        <property type="protein sequence ID" value="KAG5478517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063178.1">
        <property type="nucleotide sequence ID" value="XM_067206731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H2X6"/>
    <dbReference type="GeneID" id="92360665"/>
    <dbReference type="KEGG" id="loi:92360665"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030272">
        <property type="term" value="F:5-formyltetrahydrofolate cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009396">
        <property type="term" value="P:folic acid-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407:SF1">
        <property type="entry name" value="5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407">
        <property type="entry name" value="ATPASE INHIBITOR/5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="150"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00036539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5478517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="449" mass="48289" checksum="AA1EA61958DF3E22" modified="2021-09-29" version="1">MQPFPRAHIKKALRKEQLLRLRRWAKANPAQVAAASKQVCDHVHNYILARYRPAAATAARGPASSSPLGPTASQDLPRPVQLRPPPLLILAYLPLYFEVDLVPLLQRLWPMAHEHSIHIMTPVVLPEAVAASPAAGAAAAPPVESTSQPAPSPPFSAPSPPDYPAPHDLKSAMVFVEVLNERDLVTAFAPQGVYNIREFDNSLLKPWLLGPSRAPAFGTPAPLHSSAILEGGTGDKDDHVRRSCCHGRHRHMVLCDAYARLFPKSHAAGYRPSGLLEYSDASEDPRICFSPAAQGEVMQDLRSLDDVSILVLTPGVLFDVQTGARLGKGGGFYDRFLGYHGSAHHLRRPAGSSPPRVGSREEGDVAVSLEVVEDAAPLSASGVLVATWEVMGIAFDDQVLHPTAADTSALISGAPGSSVPLRIPVDTHDQFMHFIVSPSGGVEQVWQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H6D7</accession>
    <name>A0A836H6D7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">Aldose 1-epimerase</fullName>
            <ecNumber evidence="4 7">5.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_04657</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>alpha-D-glucose = beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:10264"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="5.1.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the aldose epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.3" evidence="4 7"/>
    <dbReference type="EMBL" id="JAFHLR010000023">
        <property type="protein sequence ID" value="KAG5478425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063086.1">
        <property type="nucleotide sequence ID" value="XM_067206639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H6D7"/>
    <dbReference type="SMR" id="A0A836H6D7"/>
    <dbReference type="GeneID" id="92360573"/>
    <dbReference type="KEGG" id="loi:92360573"/>
    <dbReference type="UniPathway" id="UPA00242"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09019">
        <property type="entry name" value="galactose_mutarotase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018052">
        <property type="entry name" value="Ald1_epimerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015443">
        <property type="entry name" value="Aldose_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047215">
        <property type="entry name" value="Galactose_mutarotase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091">
        <property type="entry name" value="ALDOSE-1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091:SF0">
        <property type="entry name" value="GALACTOSE MUTAROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005096">
        <property type="entry name" value="GALM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00545">
        <property type="entry name" value="ALDOSE_1_EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="359"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="211"/>
            <end position="213"/>
        </location>
        <ligand>
            <name>beta-D-galactose</name>
            <dbReference type="ChEBI" id="CHEBI:27667"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>beta-D-galactose</name>
            <dbReference type="ChEBI" id="CHEBI:27667"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836H890_9TRYP</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">LSCM4_02181</name>
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        <name type="scientific">Leishmania orientalis</name>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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</entry>
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        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
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                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
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                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <comment type="caution">
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            <dbReference type="EMBL" id="KAG5480315.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
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                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000020">
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    <dbReference type="GeneID" id="92362045"/>
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        <property type="component" value="Chromosome 20"/>
    </dbReference>
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        <property type="entry name" value="MORN"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216">
        <property type="entry name" value="PAXILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="3"/>
    </dbReference>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1798"/>
            <end position="1808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1818"/>
            <end position="1829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1837"/>
            <end position="1847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1946"/>
            <end position="1955"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5480420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1955" mass="202978" checksum="DED0D485AF0314D3" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HAI3</accession>
    <name>A0A836HAI3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ankyrin/TPR repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5477903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062810.1">
        <property type="nucleotide sequence ID" value="XM_067207242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HAI3"/>
    <dbReference type="SMR" id="A0A836HAI3"/>
    <dbReference type="GeneID" id="92361176"/>
    <dbReference type="KEGG" id="loi:92361176"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051616">
        <property type="entry name" value="Cul2-RING_E3_ligase_SR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46224">
        <property type="entry name" value="ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46224:SF64">
        <property type="entry name" value="IQ MOTIF AND ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="43"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="76"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="109"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="176"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="210"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5477903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="394" mass="43084" checksum="EA7517768F6DB0DD" modified="2021-09-29" version="1">MNDGIRISEEVEKFLRAARSRDTADCSQMLHEKPDLVNSVEAGGYSALHFAAFNGDVQMIYLLLEYKADTNIENMDGNTPLVMGVKGRQLECIRILANAGADVNKASASGSTAAHFAASMGYVDCLRLLVELGAKTMYAESEAGTLLHWACHSGDLDCIGAVIYELKVPIDAVDKHGGTALFTALFMKKTEAVEFLVEHGAAINIAIAEDGSTPLHIAVEHANLECVRLLCSCGADSSATNREGKTPLDLAKAAKNSAAVKELEKTQVPREKRAEEAVRFKNQGNKVFQQGENVKAAKFYTLAIHLDPANHVYYSNRAACYFNQHFYKGAYWDAMRCIKLDPSWPKGYLRKAATELALKKCSDALTTASQGLKLDPANKDLQQVKDEAFKQLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HAR1</accession>
    <name>A0A836HAR1_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5478008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062915.1">
        <property type="nucleotide sequence ID" value="XM_067207347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HAR1"/>
    <dbReference type="GeneID" id="92361281"/>
    <dbReference type="KEGG" id="loi:92361281"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5478008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="258" mass="28461" checksum="C4A7FD39972280B0" modified="2021-09-29" version="1">MVSSSSSMQMLLAHQYMHCPSAPLAVGSPATAVSAERAPRLQSRSRRLPFSVSATTGLCNGEDSTFLYSSVNHITHRLPETFGVHYPEAPYYRGRNNFDVQLVREASLSRRGRPLRSALATNSRAHTVPVASQQRRYTQAMPTRPSKDTTHSYGQLLPRLCKRSSPSAVSARRHLACNSSLPGTRTADSGQLTLFSRPDTARRQSSCPVTSDSATAMPETTLEPCMRCTVRWAVCVVRDEVAADKMVQFERFVSTVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HBE8</accession>
    <name>A0A836HBE8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">carbonic anhydrase</fullName>
            <ecNumber evidence="2">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_03784</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="2"/>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061717.1">
        <property type="nucleotide sequence ID" value="XM_067205780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HBE8"/>
    <dbReference type="SMR" id="A0A836HBE8"/>
    <dbReference type="GeneID" id="92359714"/>
    <dbReference type="KEGG" id="loi:92359714"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03124">
        <property type="entry name" value="alpha_CA_prokaryotic_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041891">
        <property type="entry name" value="Alpha_CA_prokaryot-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF265">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032453346" description="carbonic anhydrase" evidence="9">
        <location>
            <begin position="24"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="564"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="10">
        <location>
            <begin position="54"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="382"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="491"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="390"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="435"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="491"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5474611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="631" mass="67168" checksum="6F6BE8B7A648EE13" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HFS8</accession>
    <name>A0A836HFS8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_06024</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000011">
        <property type="protein sequence ID" value="KAG5485387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065124.1">
        <property type="nucleotide sequence ID" value="XM_067207950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HFS8"/>
    <dbReference type="GeneID" id="92361884"/>
    <dbReference type="KEGG" id="loi:92361884"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034338">
        <property type="term" value="F:short-chain carboxylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050960">
        <property type="entry name" value="AB_hydrolase_4_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012020">
        <property type="entry name" value="ABHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794">
        <property type="entry name" value="ABHYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794:SF63">
        <property type="entry name" value="ALPHA_BETA HYDROLASE 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005211">
        <property type="entry name" value="Ab_hydro_YheT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR005211-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5485387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="471" mass="52183" checksum="183A8DB3A8B931D1" modified="2021-09-29" version="1">MSFVGRLSFGAKHVIVHVFLYSLPRLVSGVLLRWPRWLVGQLTRGQLIAVPADEREVTIIVNEKDPYQLRMRFGLPLTGQSLRYHAPLYNGHIQTILAAMRSGPRVSYERELVESHEGQHINMDYLYPPLPFTPAPPSPATAAALSIAGATDLVKGRAPRAKGLMLIVPGLLNASTTNYVRRFAAKSVEMGFAVCVLNSRGMGTTPLEVPRLFSATFTEDIRYCLHHYLQQKHVQERLGTPKPVPLIAVGFSLGGVTLTKYLGEQGMSAAEKEQRLNLPANSVAPDTPVSALLTVTSPYDLIEADRMSATQLYRLLYEKPFAVGLRKYAKHNREMLAKLLNVDSKLLFEGPNPAIDRITSIRAFDTYINASHNGFNSPQEYYAAAQPFLWLARCRTPVLCIGDRNDVVAGCFVPDASWVELVIRNPYAVYVCYPVGGHLGFLGTPAAEWRGDATEAERFVLRAAERFCEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HGC6</accession>
    <name>A0A836HGC6_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062496.1">
        <property type="nucleotide sequence ID" value="XM_067207193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HGC6"/>
    <dbReference type="GeneID" id="92361127"/>
    <dbReference type="KEGG" id="loi:92361127"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="673"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="827"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="681"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="843"/>
            <end position="857"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5476263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="865" mass="90086" checksum="EF5F30FE39C4C3E4" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HHW2</accession>
    <name>A0A836HHW2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_04362</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">LSCM4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062556.1">
        <property type="nucleotide sequence ID" value="XM_067206347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HHW2"/>
    <dbReference type="SMR" id="A0A836HHW2"/>
    <dbReference type="GeneID" id="92360281"/>
    <dbReference type="KEGG" id="loi:92360281"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000175">
        <property type="entry name" value="Mitochondrial carrier protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF48">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="3"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="103"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="204"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5477145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="33284" checksum="133C295B173376C9" modified="2021-09-29" version="1">MNTDDAREMVAGSLGGASATVIEYPMDTIKVRLQDDGKRYGGVMQCIRTISKEEGIVNGFFRGLPAPVIGAAFENAILFASYRSAIEGFQKLTYGHCGPSNEEPYLAVSVAGAAGGIVVSQVLTPAELIKCKMQIQNTLPVQERIYKNSLECAAATYRRRGIRGLFRGHTAMMMREAVGCGFYFLAFQSVIRPFLSDGQMFHEAPAWVHFLGGGCAGVAFWTSTYPVDAVKTKQQTMKADYLKLNFRQACARLYRTEGMRGLFRGYSVTAVRAFPGNAVLIAVYEQVSAFWEYSATGAHNSLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HJP5</accession>
    <name>A0A836HJP5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_01775</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">LSCM4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000022">
        <property type="protein sequence ID" value="KAG5479186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063279.1">
        <property type="nucleotide sequence ID" value="XM_067203820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HJP5"/>
    <dbReference type="GeneID" id="92357754"/>
    <dbReference type="KEGG" id="loi:92357754"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015187">
        <property type="term" value="F:glycine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904983">
        <property type="term" value="P:glycine import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46181">
        <property type="entry name" value="MITOCHONDRIAL GLYCINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46181:SF3">
        <property type="entry name" value="MITOCHONDRIAL GLYCINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="351"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="359"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5479186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="464" mass="51022" checksum="5CACA202DE6413A4" modified="2021-09-29" version="1">MTGASTALTCSVKEADFPKIDALGKDHGKDSFLYSAGPALLSGASQAILFNPIDRALYVRVKFRRRRFLDKRNFEHPFQGFMNAAVYRTLVGASYMFWQDTMRIAIERFAPAVCRANMSPQLNSILIGLAAGSMNGFALNTLQVVKFRMWNTNERGITFLRTALHMYGEGGVLIFFRGGLTTMVRDSVFGVVYETARSASAWKHFFDKQVGVVCAVFSQPSSKWSSPQPLVGVSACVTGADKRCRGEVDAPAPVSTSGHPTANETTIDQYDAVLRDPRQKCGTCAFISNLVAAVLASILSSPFNYVRSIVYGTPAGAIPLGYIPLLKSFYTQLYYTYRHGKSYTDRHAVPELSETEHPSSASSSSSSKAAASEHRWKPCDSAVVRKEGGADVQQATRRSSLAASRLAARMRTWAQLHHHHPKAAWTWANSRLNIGWGSLRVGLGMAMGQSIFYLAQDYARNDLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HKN7</accession>
    <name>A0A836HKN7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_05732</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063437.1">
        <property type="nucleotide sequence ID" value="XM_067207664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HKN7"/>
    <dbReference type="SMR" id="A0A836HKN7"/>
    <dbReference type="GeneID" id="92361598"/>
    <dbReference type="KEGG" id="loi:92361598"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000178">
        <property type="entry name" value="Calmodulin-2 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="7"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="80"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5479726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="154" mass="17354" checksum="A0D4644EF0BA04A5" modified="2021-09-29" version="1">MGALSEDQRTRASLQFLLLDQDSDGFIRSDELGTYLRAIGLYPSQSDIASYIALVDSGEQGRVSQERALELYEKLYPQRTTLEELHAALKVLDDDADGYLTTAQLRHALVNLGTRLSVEEAEEILRDVEKDDEGMIILEDITQLLMPTESEEYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HKS9</accession>
    <name>A0A836HKS9_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_08282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000003">
        <property type="protein sequence ID" value="KAG5488057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066184.1">
        <property type="nucleotide sequence ID" value="XM_067210151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HKS9"/>
    <dbReference type="GeneID" id="92364085"/>
    <dbReference type="KEGG" id="loi:92364085"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5488057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="393" mass="44603" checksum="D4E118BFC626DA94" modified="2021-09-29" version="1">MWQRIRLLKTLSSQKGAAAPAAGAASSCPSPGAAPQSPVPSSSADNERSFLRHLIPMRVYSSGPPSIYLRHAFLHQNRLIHRFLGALEAVPLPSLPRMLLAEGFQRMLEGDAPQRELRALFEDAEAECRKMLLHLDRSEGGHRWCRDPHDQEASHGVAHDPLRRLLAYELRAACSHYARLMAVSSSPYAPAAVVVRTIIASDVRTDDFLVKMVLEFEKHPRNVETGERVGEAVPLVVEELMKELLLLERDAFGCFRFDPRGDNHHLVHCLKLADMTKTLTSYSIMLDPLMKRYGNYCVECEEVYKGRWNQYKVHCGPEDHRIDPALPLFETVIAKDPITGGALNMIVHYDEPICLRHKHSSREEKGNFGHTEVFELAIEAKNRTLWERYFLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HML1</accession>
    <name>A0A836HML1_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
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</entry>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000015">
        <property type="protein sequence ID" value="KAG5482996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064492.1">
        <property type="nucleotide sequence ID" value="XM_067209109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HRQ8"/>
    <dbReference type="SMR" id="A0A836HRQ8"/>
    <dbReference type="GeneID" id="92363043"/>
    <dbReference type="KEGG" id="loi:92363043"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5482996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="490" mass="53282" checksum="4A18ABB0955F2FAC" modified="2021-09-29" version="1">MPSEVEELLAKHQRKFAAHEEFLLSNTTTPSPNPQRRRQWVGPNATVLSIHHNGARDAYGLSGVSDDDRKEVRIERSYSRDRHASPAAHAPTAAMTSVASAAAVARAIATYGDLLGPAYYATGLHTGAPPPLQRRSTSRSMRDTHTASAAASASHPRTSTSGLDDIDYLIGERLRMAGRYHLGSTPDAIYIKSQAWALRRDQVNDALRREQEDAKLRECTFSPNLRHVTMKGTSEVSVMCNGGSSHSPTAPAAAEASVTEDPGVLQHFARLEEARRRRRESAARLNGRKAHRWTGQPTVPHEFQLGLRVAEPILSLRKPYMPNAGGGGGGRTASSPDRDTREEFVARASAARRAVQKQCSFSCLPPSNDGDRLGGRTPAPVPAAVDAAKSLLNAQQERVRGQERELDAQQPLASSTTLIPETADSESPTAEPQRLFVDVDTQDLACGLTEQLAHRDPLVQTQVEDLVRLSRELDVVIETLHQISPLGTSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HT08</accession>
    <name>A0A836HT08_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inosine/uridine-preferring nucleoside hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_04835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IUNH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000014">
        <property type="protein sequence ID" value="KAG5483686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064625.1">
        <property type="nucleotide sequence ID" value="XM_067206816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HT08"/>
    <dbReference type="SMR" id="A0A836HT08"/>
    <dbReference type="GeneID" id="92360750"/>
    <dbReference type="KEGG" id="loi:92360750"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02649">
        <property type="entry name" value="nuc_hydro_CeIAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.245.10:FF:000014">
        <property type="entry name" value="Nucleoside hydrolase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052775">
        <property type="entry name" value="IUN_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46190:SF1">
        <property type="entry name" value="SI:CH211-201H21.5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46190">
        <property type="entry name" value="SI:CH211-201H21.5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="Nucleoside hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inosine/uridine-preferring nucleoside hydrolase" evidence="2">
        <location>
            <begin position="6"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5483686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="352" mass="39233" checksum="56C41F1580EB5EFF" modified="2021-09-29" version="1">MPRRKIIIDTDCGGDDAIGIMTALVDPNTDVIAMTVVWGNVDVNQGMENLGKLLDVFELDIPFYKGAEAPLVSDPETVQWGGFGKDGFGDADFPPSARVQKQAKTHAALAIIELLRAAKPDEDTVYQLVCLGPLTNIALAMRLEPDVFYVLGSETEPAITIMGGASEAKGNSNLTSEFNIHCDPEAAYIVFNQRHMRPIRVVSWEVTVECSMKWTFFDEWIGRQEGGGKVQNRFQVFIEKVFQRLETFTRPLPDGTKADTGDAEATQDDTCVIPDAVAMIAALYPESILDRFITYCTVELHGRETRGQTCLDWYGTKQSMAKRGRWNNCELIIRVDNTRFLEAMSEILKYKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HUB2</accession>
    <name>A0A836HUB2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_07958</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000013">
        <property type="protein sequence ID" value="KAG5484391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064884.1">
        <property type="nucleotide sequence ID" value="XM_067209834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HUB2"/>
    <dbReference type="GeneID" id="92363768"/>
    <dbReference type="KEGG" id="loi:92363768"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5484391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="17040" checksum="984DBDBF6B641A34" modified="2021-09-29" version="1">MPIPVDNEITLPDCNQNLGRHEYVVAGYGSLCMEPAAGQSRVLYRVPTLKSWSRDFWYVWLIVLLLIAFGVIGCAFQSLRWYRRLQHRYEREVRLKRVDGMVRLMSSIYSRRSTSASQQRTRASSLCPSNRRSESLDMRDVSDDDGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HVL1</accession>
    <name>A0A836HVL1_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_04852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000014">
        <property type="protein sequence ID" value="KAG5483700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064639.1">
        <property type="nucleotide sequence ID" value="XM_067206830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HVL1"/>
    <dbReference type="GeneID" id="92360764"/>
    <dbReference type="KEGG" id="loi:92360764"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5483700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="162" mass="17197" checksum="FA3EA98474A181AC" modified="2021-09-29" version="1">MLHSQRLLCWVKPILLGRILLNLLSVLGSSIIAAPLADGTFVDLGISFWTAVSASGLVFSTVIFLFAGGVRCEGRWPQRGRSAASPEHASRAGGGAAGAQIAFPLSQPGNLLLGCVCPLRVKISAVQHQLIRLLRQPQRSVEPRLRAAVPRPAAEHAGGRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HVU3</accession>
    <name>A0A836HVU3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cilia- and flagella-associated protein 43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_04975</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000014">
        <property type="protein sequence ID" value="KAG5483820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064759.1">
        <property type="nucleotide sequence ID" value="XM_067206950.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836HVU3"/>
    <dbReference type="GeneID" id="92360884"/>
    <dbReference type="KEGG" id="loi:92360884"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="Cilia- and flagella-associated protein 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14885">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 43-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14885:SF3">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="937"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1186"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1409"/>
            <end position="1438"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1260"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1358"/>
            <end position="1385"/>
        </location>
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    <feature type="coiled-coil region" evidence="8">
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            <begin position="1462"/>
            <end position="1510"/>
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            <end position="1732"/>
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            <end position="1432"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="EMBL" id="KAG5483820.1"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1742" mass="193245" checksum="22E8237348B1B158" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HW32</accession>
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        <recommendedName>
            <fullName evidence="2">DUF2779 domain-containing protein</fullName>
        </recommendedName>
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    <gene>
        <name evidence="3" type="ORF">LSCM4_05972</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
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            <taxon>Leishmania</taxon>
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    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <end position="883"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="Pfam" id="PF11074"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5485336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836HZG6_9TRYP</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">LSCM4_06653</name>
    </gene>
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        <dbReference type="NCBI Taxonomy" id="2249476"/>
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            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5485695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="330" mass="34448" checksum="5CD38E966CC5C760" modified="2021-09-29" version="1">MKFHLHVVDGTAPARDVAVSPSSYPPSVTESTQTTAVMLFAHMTLRCGHLSDVLAVSASTTPALARAAALQPQQSQLHSGAAQLGNADASVSEDTQVLYMAGKLLSGVVDNGAAVDLPYMDSDSGDARIVPYAYFKSSFCEAEESLRRAVCVLAESGTAASPPYFDLIATTDMATFDYIIEYYQQQRVRHGGAITKGRGTKPVGVIHIVADDPSRAALVLQRVVELMLKRSGWTFSVDAHSAEEEEKALAAQADEDEDDDRMDEVSDGEEGGASRGVTGGRGGGASAGTGGGSAQAGAQSGSAGSWVNHIDEAVHLFAQLFGVDVLVALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836I074_9TRYP</name>
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        <recommendedName>
            <fullName evidence="4">CYC2-like cyclin</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">LSCM4_08076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000005">
        <property type="protein sequence ID" value="KAG5487631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneID" id="92363886"/>
    <dbReference type="KEGG" id="loi:92363886"/>
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        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF108">
        <property type="entry name" value="PROTEIN CNPPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="219"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="486"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="820"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="946"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1005"/>
            <end position="1069"/>
        </location>
    </feature>
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    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Synthesizes selenophosphate from selenide and ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>hydrogenselenide + ATP + H2O = selenophosphate + AMP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18737"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16144"/>
            <dbReference type="ChEBI" id="CHEBI:29317"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.9.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the selenophosphate synthase 1 family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.9.3" evidence="5"/>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058757.1">
        <property type="nucleotide sequence ID" value="XM_067202656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836K9G4"/>
    <dbReference type="SMR" id="A0A836K9G4"/>
    <dbReference type="GeneID" id="92356590"/>
    <dbReference type="KEGG" id="loi:92356590"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004756">
        <property type="term" value="F:selenide, water dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016260">
        <property type="term" value="P:selenocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02195">
        <property type="entry name" value="SelD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000023">
        <property type="entry name" value="Putative selenophosphate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.650.10:FF:000010">
        <property type="entry name" value="Selenide, water dikinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="entry name" value="PurM-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="entry name" value="PurM-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004536">
        <property type="entry name" value="SPS/SelD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00476">
        <property type="entry name" value="selD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10256:SF0">
        <property type="entry name" value="INACTIVE SELENIDE, WATER DIKINASE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10256">
        <property type="entry name" value="SELENIDE, WATER DIKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036407">
        <property type="entry name" value="Selenphspht_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="PurM C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="PurM N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0711">Selenium</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PurM-like N-terminal" evidence="17">
        <location>
            <begin position="88"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like C-terminal" evidence="18">
        <location>
            <begin position="203"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00068713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00077475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAG5465126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="398" mass="43089" checksum="CDC1213AEE875B13" modified="2021-09-29" version="1">MSHKRPHSSAREANGTADLKKPRFDPVSLGLPAEFQLTDYTRLKGCSCKLPQPKLLALLREVSATPGQKDIGMDCSIVPLHSMNSKGEALFLVSTTDFFFPSVSDPFLQGQIGAANVLSDLYSMGIAHCDTMLMLLAASTDMDEHERLITTREIMKGFAERARFAATTVTGGQTVMNPWPLIGGVAMAVVSEAEMVRPSGLLRSGDILVLTKPLGCQVAVNLKQWLLRPSPLYEETIAGHITPGEIEELYNMATDSMRRLNREGARLMRKHGAHGATDVTGFGILGHANNFGAAQDVGDMPRSLCLVLERLPMFKTAVAASKRMNDKYRLLEGYSAETSGGLLVAFPSTTAAEAFCTELEEADGGCPSWIVGFVEDRAASAVDGVYARLKEGYEIIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836K9G7</accession>
    <name>A0A836K9G7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Aminopeptidase P1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_00593</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058772.1">
        <property type="nucleotide sequence ID" value="XM_067202671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836K9G7"/>
    <dbReference type="SMR" id="A0A836K9G7"/>
    <dbReference type="GeneID" id="92356605"/>
    <dbReference type="KEGG" id="loi:92356605"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226:SF4">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase P N-terminal" evidence="7">
        <location>
            <begin position="41"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24" evidence="6">
        <location>
            <begin position="391"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5465141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="827" mass="90045" checksum="0C31E3EF53F726E8" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836K9J2</accession>
    <name>A0A836K9J2_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_00685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836K9J2"/>
    <dbReference type="GeneID" id="92356695"/>
    <dbReference type="KEGG" id="loi:92356695"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5465231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="149" mass="16033" checksum="D8C98099427922B9" modified="2021-09-29" version="1">MLFRSRRSRSSSGGLSPRHAGSLSYERPSSAPVAGVVPPQPSTSAPVLPISGSLAGIHSVEDRLRIVKRNRPCDDLTRTPPSSRLQEALTVASDSSYPLVNVSTSVTAGTVPPCAAYPTFNLSRLPKHERYLMDAMVRELTDVLFFAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KA95</accession>
    <name>A0A836KA95_9TRYP</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    <gene>
        <name evidence="2" type="ORF">LSCM4_00193</name>
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    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067202282.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="loi:92356216"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5464752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="496" mass="56250" checksum="EC15339FA4D398D0" modified="2021-09-29" version="1">MRQKNIDQGAVGSLAQMRDEMCKSFQTAKVMQHTNQNSSGSEVANLLKNTSDLFLRGTKNLSSPEGDLMEVKNALTRATDAESEVAALRAEKARLQSRAEGCYSPVKLGGSDADAEAFVAYAKELSELHDHLSLSRTVFKAVLSKSLEDVRDGRLSQQDRRFTDPQSWDAKKGMLQRALQSLRTKTAQLNLSARTYLDEDETLFAEVMDLATRASDHVGRGNTMRETRDAKLERFFAECAKLTGWCRQQLTNLEAMQEPDHVQEYCATLAENYRTMSNNFAVLFDSVHEYVQANLASVQKALLEAEEVWLYLQVSTLERLSKTLFEIHPNSPLHVEVEKYSSYSEHAAKFLQELQRYMAAPRSRQRELGDLGSLQSQCQQVSQALSDELGELPSEVRAFAQRAQALRVGYQCFREAVLQRLTYISPVADTVIESKRRQDELDDCVRELKSWAVETSRGESWRDIYSKIVEIKQMIKSEQSSLEAKRVRAMESAQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KAM0</accession>
    <name>A0A836KAM0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Small GTPase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_00625</name>
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    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058803.1">
        <property type="nucleotide sequence ID" value="XM_067202702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KAM0"/>
    <dbReference type="SMR" id="A0A836KAM0"/>
    <dbReference type="GeneID" id="92356636"/>
    <dbReference type="KEGG" id="loi:92356636"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:GTP binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of TORC1 signaling"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="RagC_like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="GTP-binding protein GTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039400">
        <property type="entry name" value="RagC/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF2">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5465172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="365" mass="40946" checksum="2560307363856F27" modified="2021-09-29" version="1">MSNDMLALPKVLLMGLRKSGKSSIQKVVFEGMQPHDSVTLATTVQPEKSTVHSNDFVNFEVWDFPGQNDPFDPNNASRYDVSQLLENCGAIVYVLDCRELIEDARARLLDTISAAYRYNPELCVEVFIHKVDALSEDHQADLLASLQRRVEEEAKQLLENVQPLRLNFNLTSIYDHSVFQAFSLVVQKLIKSKTPYITELLQMLNSNSNIDLSYLFLSHSKIYLAVDERNRLKSRTYDLCSDAIEVVVKMSCIYMRRRDSVAAAVTEPSAESVHTLVSKAANATTVSSSSGSTDGCGTDMSDLYRGANAVIQLSNEDCIYVRELPSSLTLVLMMKQTHLENRALIDRNVDIFYRAAFDIFNTSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KBH6</accession>
    <name>A0A836KBH6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_01289</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059037.1">
        <property type="nucleotide sequence ID" value="XM_067203346.1"/>
    </dbReference>
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        </source>
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        </source>
    </evidence>
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</entry>
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                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="197" mass="22718" checksum="8843C0AB3895A9A9" modified="2021-09-29" version="1">MLSSTGPRRAVFHNAPSVYPFTKPFHDTPYDQDRGRFDKTKNLLRDNKWPAWMDQGADGTGFGIGLNRAHPLSKLRGNLRRNPSEVPRVLNMMIQGVWHKSGNKLYFRGGKPPNPSTHPYLTGEPCPVYGWKITDPGVIREFNLPKPERDRRYKPYVALQERKIMGMQAPLHEQSPLTTSEESTDSKPLMKRLFFWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name type="scientific">Leishmania orientalis</name>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
            <dbReference type="EMBL" id="KAG5468020.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="3">DNA-direcetd RNA polymerase II, subunit 9</fullName>
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        <name type="scientific">Leishmania orientalis</name>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG5474574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061680.1">
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="InterPro"/>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
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        </recommendedName>
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        <name evidence="12" type="ORF">LSCM4_03930</name>
    </gene>
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        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061860.1">
        <property type="nucleotide sequence ID" value="XM_067205923.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92359857"/>
    <dbReference type="KEGG" id="loi:92359857"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071561">
        <property type="term" value="C:nucleus-vacuole junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001155">
        <property type="entry name" value="Protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055231">
        <property type="entry name" value="2AA_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045162">
        <property type="entry name" value="Vps15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583:SF0">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22956">
        <property type="entry name" value="VPS15-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="316"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="1851"/>
            <end position="1892"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="1993"/>
            <end position="2007"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="136"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="916"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="926"/>
            <end position="945"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5474754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="2013" mass="213789" checksum="90283AFD3164D9DF" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KGP1</accession>
    <name>A0A836KGP1_9TRYP</name>
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        <recommendedName>
            <fullName evidence="10">NF-X1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_03502</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NFX1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061439.1">
        <property type="nucleotide sequence ID" value="XM_067205502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KGP1"/>
    <dbReference type="SMR" id="A0A836KGP1"/>
    <dbReference type="GeneID" id="92359436"/>
    <dbReference type="KEGG" id="loi:92359436"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06008">
        <property type="entry name" value="NF-X1-zinc-finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034078">
        <property type="entry name" value="NFX1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000967">
        <property type="entry name" value="Znf_NFX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12360">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR, X-BOX BINDING 1 NFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12360:SF12">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR NF-X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01422">
        <property type="entry name" value="zf-NF-X1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00438">
        <property type="entry name" value="ZnF_NFX"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="NF-X1-type" evidence="10">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="NF-X1-type" evidence="10">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="NF-X1-type" evidence="10">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="NF-X1-type" evidence="10">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="NF-X1-type" evidence="10">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="NF-X1-type" evidence="10">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="NF-X1-type" evidence="10">
        <location>
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            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="NF-X1-type" evidence="10">
        <location>
            <begin position="542"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5473436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="578" mass="63367" checksum="2672A0D8AB81764B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KGQ7</accession>
    <name>A0A836KGQ7_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_00396</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058579.1">
        <property type="nucleotide sequence ID" value="XM_067202478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KGQ7"/>
    <dbReference type="GeneID" id="92356412"/>
    <dbReference type="KEGG" id="loi:92356412"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5464948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="311" mass="37040" checksum="DE61A3F49573FC02" modified="2021-09-29" version="1">MKLLAARSPLWMLDSCQAFSSQCRWYLIKSDKKQNEELKNVELVPTFEHDRIVQDSESTRPTCISEKDDDTLEPLSQGLMNTMEETPYRVSWYDFQTVSPAKRFTYWVYRRLRDLPPEWQEYYRSMVYQEISASRYVNQTWDCFMMVVDGYRKAKWVLRKYGVKVDESLIPRPYNNFWEETTHEERVWAHRRSHQMKELQALQREDDEIVFGASIMNRNEVSYTSLKNLQTGMQGGTPLHAHDLPAPKESELRMSRQDEEMSSALMSSIEDDKLWNPVLRSRLHTQFQRAEAELYSFEDDDDGDTHHFQQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KHZ1</accession>
    <name>A0A836KHZ1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome biogenesis protein NOP53</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_01429</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NOP53 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059173.1">
        <property type="nucleotide sequence ID" value="XM_067203482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KHZ1"/>
    <dbReference type="SMR" id="A0A836KHZ1"/>
    <dbReference type="GeneID" id="92357416"/>
    <dbReference type="KEGG" id="loi:92357416"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011687">
        <property type="entry name" value="Nop53/GLTSCR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14211">
        <property type="entry name" value="GLIOMA SUPPRESSOR CANDIDATE REGION GENE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14211:SF7">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NOP53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07767">
        <property type="entry name" value="Nop53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017302">
        <property type="entry name" value="Gltscr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="120"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5466283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="337" mass="37532" checksum="586FC0E8E75DB48A" modified="2021-09-29" version="1">MGRQKSRNLWNDELNTKCVNRPQQVTVAKGWKVTPDLLPAKPLAPRRRKYAPIRPNNRDAVAIPLGGQSYNPVDAEHQEALAKAVRQLTRKKLKDEKFVKMMTMGRANKYTGNFSADKTWEEEVQETAPATAKPQKKNTKGAPSSTGASPSSTPPAPSAAAPNSSEGKEAKIAAASAVVAKDSKAAKKKRKTKKATAEEAKRAMVHRRHPQRDTVAKETDDLDKLLAAHTATLKKREASRQKRRAAKKANLAIKHYGRHYHTPLVVDVMPSDKLVGSLRHLSGGYVHPVMERMKSLEERNLVPARMRHTYNKRKVLKPKGEVRLKREESGVMPETSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KI11</accession>
    <name>A0A836KI11_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059248.1">
        <property type="nucleotide sequence ID" value="XM_067203557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KI11"/>
    <dbReference type="GeneID" id="92357491"/>
    <dbReference type="KEGG" id="loi:92357491"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5466358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="238" mass="25818" checksum="98AE565629C60B59" modified="2021-09-29" version="1">MDSSTGTALAAAVRANSALPATSASSSQPSSPPHRFSAEAAPFVPSYMRDPVLPAAAAPVELAPQETSSAAGLGDGECGGEGDDTDRRRFSKMWVYCLEQMQGHEVGMLMDMMPPDIQELYSDKLSDEYLLNQHEHNDKGAHALCAVQKMVQELTPEQFDHIEEFLEETDALNPEVKRCRRKEGHPPGDGDNLEEDDSAADGGEDLFMHDDDGMGSEEEEWLLEQMMATGDKASAASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KI40</accession>
    <name>A0A836KI40_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aquaglyceroporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_03092</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">LSCM4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060662.1">
        <property type="nucleotide sequence ID" value="XM_067205110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KI40"/>
    <dbReference type="SMR" id="A0A836KI40"/>
    <dbReference type="GeneID" id="92359044"/>
    <dbReference type="KEGG" id="loi:92359044"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015254">
        <property type="term" value="F:glycerol channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050363">
        <property type="entry name" value="MIP/Aquaporin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00861">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829">
        <property type="entry name" value="AQUAPORIN OR AQUAGLYCEROPORIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829:SF9">
        <property type="entry name" value="AQUAPORIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="287"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5471545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="35252" checksum="DAAE61F0E6D1E7C7" modified="2021-09-29" version="1">MTNSPLQTPHTSYEEEFQEYLRKEDSHDVIMGHEFDEGNPEQKDEQKRNFTTQDMWPLYQHRWWLREYAAEFFGTFFLLSFGTGVNATTMFHAGATASYQTNVSYLAVTFGWACGLAVALFMSMGVSGGHLNPAVTISNCVFGAFPWKKAPGFFVAQLLGSMTGAANVYGLFKPHFDEAQQNLLPHETMASKFSGIFVTYPSVPNGYAVWSEVFNTMALMMGVLAVTDSRMTPALNFKPVAVGLLVFVIGITTGVNSGFAINPTRDLGPRMLTAMLWGSEPFTLYSYYFWIPTFMPFVGALLGMFLYVFFIIPPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KID4</accession>
    <name>A0A836KID4_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060917.1">
        <property type="nucleotide sequence ID" value="XM_067205365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KID4"/>
    <dbReference type="GeneID" id="92359299"/>
    <dbReference type="KEGG" id="loi:92359299"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5471800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="225" mass="25555" checksum="2AACBB1806EC480C" modified="2021-09-29" version="1">MSGFLPRAQKAKAAGTDRGGMYLSPPRLPVRRQFVVEKQGRFDYTVWNTRILTIDTRKCHIYLSKAQNAENLDHRCMYRIDSVELWPRFSYDRICEPFGSEPARLTLCVTGLVGTKTTSFFTRLLGGEGMGKKQIVDFPSQVTEARNAAAQIQRSSRHGSDSLDTIEPSTLSSIWDYNCFNVEVWVIRCMTHPDLYKMAKALRATITEASVMKGYHALKKRMSMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KIQ7</accession>
    <name>A0A836KIQ7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Obg-like ATPase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_04315</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062239.1">
        <property type="nucleotide sequence ID" value="XM_067206302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KIQ7"/>
    <dbReference type="SMR" id="A0A836KIQ7"/>
    <dbReference type="GeneID" id="92360236"/>
    <dbReference type="KEGG" id="loi:92360236"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01900">
        <property type="entry name" value="YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.300:FF:000001">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000001">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="entry name" value="TGS-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00944">
        <property type="entry name" value="YchF_OLA1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041706">
        <property type="entry name" value="YchF_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00092">
        <property type="entry name" value="redox-regulated ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF11">
        <property type="entry name" value="OBG-LIKE ATPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006641">
        <property type="entry name" value="CHP00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="4">
        <location>
            <begin position="23"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="5">
        <location>
            <begin position="301"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="32"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5475731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="392" mass="43944" checksum="D7A9CBEAD3FA4C66" modified="2021-09-29" version="1">MPPKKQEKEESKTVLLGRPGSHLKVGIVGLPNVGKSTFFNVLSKKGVPAENRPFCTIDPNTADINIPDDRFDKLVRIHKPASIVPAQVHICDIAGLVRGASSGEGLGNNFLSHISSCDGLIHMVRVFEEMEITHVEGDLDPIRDLEIIFSELVMKDLQSVNGLIDKLTPVVNRGLDKSKKGDLETLHKVKGVLEEGKQVRCCQWSGKEIDFLNTIQLLTAKPAMFLVNMSESDYVRQRNKWLKKLKEWIDEHTGEPMIPFSAELETTFVAMPPEEADKYCEEKKTKSQIHKIINTAYSIINLIHYFTAGADEVKCWTIQRGTKAPQAAGKIHTDMEKGFICAEVIEWGDFDRLESEAACRDEGKQHQQGRNYEVQDGDIIFFKFNAAKGGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KK00</accession>
    <name>A0A836KK00_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Adenylate kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_04797</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000023">
        <property type="protein sequence ID" value="KAG5478564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063225.1">
        <property type="nucleotide sequence ID" value="XM_067206778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KK00"/>
    <dbReference type="SMR" id="A0A836KK00"/>
    <dbReference type="GeneID" id="92360712"/>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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            <dbReference type="EMBL" id="KAG5478564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="29706" checksum="0F162E30CAE6757A" modified="2021-09-29" version="1">MASAAYYKKKQAQQHLAISEVQAITEALVATVAQSRPRSPLRALLHALDRMEGEQTGAVSAVADSAPPLVTPLLVLLTGPPGCGKSVQASHIAASLGGVHCAVPSLVRDAVNGGRLPGAKDAYVPLPLQAEVRAAKVSAALQTPPLPLAPASPSSLPSDLAARLILNRIQYETGQRRAAADAASAAGLQRPPSTVLFVLDGYPSTIGEALTLEAATGQEISVVVALRCSVECLQARRRSPASSVRLASLSIFEEYWDAQHKLRVVDGSQSIPAVTRQALTILQGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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        <name evidence="2" type="ORF">LSCM4_06489</name>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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            <end position="284"/>
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            <begin position="65"/>
            <end position="138"/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5480919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="350" mass="39866" checksum="2DBCAE8795F2D94B" modified="2021-09-29" version="1">MTALITTQRYNWMGYNGTETEEVDTALMRAADMPLNNYNYLHRQRVIMELKERLLQIKRELDLAPPEDRHSEEEARRRRQEQKRLEEEERMRREAEEAERAEAERQRLELEAAEEEARRQQEAMEREATQRKNMHEIDLNSDDSDASDEYSAVLEARAWTQKEIDEAIEGFVKGTRSLLSCTGNGYVSYLDGSTHPTTDKLDAYNVSKLEDLTTAMAGTYFDMPAAEEHSLEEVCAARDERDVARKKLEALRALEDRTYSVRIRSTEKDADGQPKQQLTPDDSDVSALTVNFEAAKQLSETIRKAYNEKASASGNVIAAALCMRAISASPEAEAAVTVLESESKKQRVAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KMP3</accession>
    <name>A0A836KMP3_9TRYP</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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        <name evidence="2" type="ORF">LSCM4_05189</name>
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    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
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            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_067207140.1"/>
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    <dbReference type="KEGG" id="loi:92361074"/>
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            <begin position="2000"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5476210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="2426" mass="250169" checksum="BC30D4B97986F02F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KMT7</accession>
    <name>A0A836KMT7_9TRYP</name>
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        </recommendedName>
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        <name evidence="7" type="ORF">LSCM4_03095</name>
    </gene>
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        <lineage>
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            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">LSCM4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
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            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067205113.1"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A836KMT7"/>
    <dbReference type="GeneID" id="92359047"/>
    <dbReference type="KEGG" id="loi:92359047"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000019">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033106223" description="Peptidyl-prolyl cis-trans isomerase" evidence="5">
        <location>
            <begin position="21"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="66"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5471548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="229" mass="24618" checksum="B66EDD5309452835" modified="2021-09-29" version="1">MALRFSFALMAGGALHSCLASPRANAASASKPYLTPYPTNPHNSRVFFDVAEEGGSSFFGMTTQVPIGRIEFELFDDTVPVTARSFRELCRGTSSKSPEGRLLTFKGCVFHRIIPDFMIQGGDITKGNGTGGCSIYGTRFKDESFNGKAGKHKGAGILSMANAGRNTNGSQFFICTVACPWLDGKHVVFGQVLRGYEHVKKLEGYGTPHGKPSKTVMISDCGVVQEMSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KNP1</accession>
    <name>A0A836KNP1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA mismatch repair proteins mutS family domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_05820</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063523.1">
        <property type="nucleotide sequence ID" value="XM_067207750.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92361684"/>
    <dbReference type="KEGG" id="loi:92361684"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF139">
        <property type="entry name" value="REPAIR PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="5">
        <location>
            <begin position="1424"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="222"/>
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    </feature>
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        <location>
            <begin position="784"/>
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        </location>
    </feature>
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        <location>
            <begin position="880"/>
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        </location>
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        <location>
            <begin position="1025"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1189"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1037"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1078"/>
            <end position="1087"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5479812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1569" mass="166610" checksum="A630537C2C832C3C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KNP3</accession>
    <name>A0A836KNP3_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_04448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062641.1">
        <property type="nucleotide sequence ID" value="XM_067206432.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92360366"/>
    <dbReference type="KEGG" id="loi:92360366"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="3214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
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            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="249"/>
        </location>
    </feature>
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            <end position="298"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="340"/>
        </location>
    </feature>
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            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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            <begin position="496"/>
            <end position="510"/>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
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            <end position="609"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <end position="677"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
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    </feature>
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    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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    </feature>
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        <location>
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        </location>
    </feature>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
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            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <sequence length="408" mass="45582" checksum="58A096602DCABF77" modified="2021-09-29" version="1">MEERDQPITDDHRKLIFSFIRMMRRSQVENPERAEAVAQMLGEEFGVDPAGSGGLYDTGVDVLEAFKTALREHERRSGAEQDEKFVSFVELLEKKGYFKGVEKGSDEYAQRLEKARDKFNQRNNPYEGLTAEQIKNKGNELMSQAKYKEAIAYYTKAIELESNNAVFFANRAAAHTHLKDYNNAIIDCERAIIINPEYSKSYSRLGTALFYQENYSRAVDAFTKACELDPDNATHKEDLKRAEEKAKATGLTTGSGMGGFPGMGGFPGMGGMPDMSQFANMMNNPQFMETAQRMMQNPEFSNLVANMAGKFSQGGMDPAELNRLGADMGMRNVDEDGNVVTPFGKVNRAAIEQLQEEEVRKNPKLAGIMADVQANGYGAFQKYLGDPDVMSLMMKFQSLMFTNPNNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836KSU4_9TRYP</name>
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        <submittedName>
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        <name evidence="10" type="ORF">LSCM4_06740</name>
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    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000009">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="loi:92362588"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005242">
        <property type="term" value="F:inward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034765">
        <property type="term" value="P:regulation of monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="G protein-activated inward rectifier potassium channel 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016449">
        <property type="entry name" value="K_chnl_inward-rec_Kir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013518">
        <property type="entry name" value="K_chnl_inward-rec_Kir_cyto"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767">
        <property type="entry name" value="INWARD RECTIFIER POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767:SF102">
        <property type="entry name" value="INWARDLY RECTIFYING POTASSIUM CHANNEL 1, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0630">Potassium</keyword>
    <keyword evidence="2 7" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <keyword evidence="3 7" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="324"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="357"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="381"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="454"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="534"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5486034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="739" mass="80285" checksum="54EA30863FDEF72D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KT81</accession>
    <name>A0A836KT81_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">RNA cytidine acetyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">18S rRNA cytosine acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LSCM4_06974</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires a tRNA-binding adapter protein for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in 18S rRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51424"/>
            <dbReference type="Rhea" id="RHEA-COMP:13575"/>
            <dbReference type="Rhea" id="RHEA-COMP:13576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a cytidine in tRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in tRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53876"/>
            <dbReference type="Rhea" id="RHEA-COMP:13670"/>
            <dbReference type="Rhea" id="RHEA-COMP:13671"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
            <location evidence="1 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="10"/>
    <dbReference type="EMBL" id="JAFHLR010000017">
        <property type="protein sequence ID" value="KAG5481895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064255.1">
        <property type="nucleotide sequence ID" value="XM_067208881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KT81"/>
    <dbReference type="SMR" id="A0A836KT81"/>
    <dbReference type="GeneID" id="92362815"/>
    <dbReference type="KEGG" id="loi:92362815"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990883">
        <property type="term" value="F:18S rRNA cytidine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904812">
        <property type="term" value="P:rRNA acetylation involved in maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051391">
        <property type="term" value="P:tRNA acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002218">
        <property type="entry name" value="tRNA(Met) cytidine acetyltransferase TmcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03211">
        <property type="entry name" value="RNA_acetyltr_Nat10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033688">
        <property type="entry name" value="NAT10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007807">
        <property type="entry name" value="TcmA/NAT10_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032672">
        <property type="entry name" value="TmcA/NAT10/Kre33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013562">
        <property type="entry name" value="TmcA/NAT10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027992">
        <property type="entry name" value="tRNA_bind_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925">
        <property type="entry name" value="N-ACETYLTRANSFERASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925:SF5">
        <property type="entry name" value="RNA CYTIDINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13718">
        <property type="entry name" value="GNAT_acetyltr_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05127">
        <property type="entry name" value="NAT10_TcmA_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08351">
        <property type="entry name" value="TmcA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13725">
        <property type="entry name" value="tRNA_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TmcA/NAT10 N-terminal" evidence="13">
        <location>
            <begin position="25"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="TcmA/NAT10 helicase" evidence="12">
        <location>
            <begin position="307"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="14">
        <location>
            <begin position="539"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="domain" description="Possible tRNA binding" evidence="15">
        <location>
            <begin position="798"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="696"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="981"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1056"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="997"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1056"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="481"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="654"/>
            <end position="656"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="661"/>
            <end position="667"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="766"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF13725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG5481895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1083" mass="118405" checksum="9D78A00C689D56D0" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KT94</accession>
    <name>A0A836KT94_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_07591</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="8">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
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        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
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        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the proteasome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
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            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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</entry>
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            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="nucleotide sequence ID" value="XM_067210233.1"/>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
    <sequence length="1859" mass="198304" checksum="72DE175937FB3249" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FLR1</accession>
    <name>A0A836FLR1_9TRYP</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">LSCM4_00445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
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            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067202527.1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="16"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5464997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="184" mass="21634" checksum="52ACD3AD02A0644E" modified="2021-09-29" version="1">MRRTRLVHTATPEKFSILGTTHPKPKRNGLGRDNKMRSKPSDNVAWYDKGPVEWLPRPVRLTYDQLDQLRDWMMRETISGRTEEFNKIRHLHREWSQHPLMPMLGDVEPKFPLNLYKQNHRARRRFLVRWHKANSPTYWMWMPRGPAIATPLHRSSPSQFPEQWKQLARNSGGSSSSGSGFVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FM21</accession>
    <name>A0A836FM21_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MIF4G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_00645</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4G family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058823.1">
        <property type="nucleotide sequence ID" value="XM_067202722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836FM21"/>
    <dbReference type="SMR" id="A0A836FM21"/>
    <dbReference type="GeneID" id="92356656"/>
    <dbReference type="KEGG" id="loi:92356656"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253:SF9">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G" evidence="5">
        <location>
            <begin position="84"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="337"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="346"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="368"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="392"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="412"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5465192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="761" mass="84445" checksum="DBE21B75265BD032" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FVP2</accession>
    <name>A0A836FVP2_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02896</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060468.1">
        <property type="nucleotide sequence ID" value="XM_067204916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836FVP2"/>
    <dbReference type="GeneID" id="92358850"/>
    <dbReference type="KEGG" id="loi:92358850"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5470202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="133" mass="14547" checksum="94C1884795BA2BDC" modified="2021-09-29" version="1">MGTSSSREWFNPYAINTPLAGVCAVSCLFNSVSNGTLRISNVYTNITLLIILGCSNGLSNSLHMPLLGAQAGLAASLLFTLGAPMKILFTSRLFPRSVHYGIGTFYITYHAMQMHKERNYFEDAGEDCEDDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G086</accession>
    <name>A0A836G086_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoglycerate mutase (2,3-diphosphoglycerate-independent)</fullName>
            <ecNumber evidence="4">5.4.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LSCM4_00711</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BPG-independent phosphoglycerate mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.12" evidence="4"/>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058887.1">
        <property type="nucleotide sequence ID" value="XM_067202786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G086"/>
    <dbReference type="SMR" id="A0A836G086"/>
    <dbReference type="GeneID" id="92356720"/>
    <dbReference type="KEGG" id="loi:92356720"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004619">
        <property type="term" value="F:phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006007">
        <property type="term" value="P:glucose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16010">
        <property type="entry name" value="iPGM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1450.10:FF:000002">
        <property type="entry name" value="2,3-bisphosphoglycerate-independent phosphoglycerate mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1450.10">
        <property type="entry name" value="BPG-independent phosphoglycerate mutase, domain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011258">
        <property type="entry name" value="BPG-indep_PGM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006124">
        <property type="entry name" value="Metalloenzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036646">
        <property type="entry name" value="PGAM_B_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005995">
        <property type="entry name" value="Pgm_bpd_ind"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01307">
        <property type="entry name" value="pgm_bpd_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31637">
        <property type="entry name" value="2,3-BISPHOSPHOGLYCERATE-INDEPENDENT PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31637:SF0">
        <property type="entry name" value="2,3-BISPHOSPHOGLYCERATE-INDEPENDENT PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06415">
        <property type="entry name" value="iPGM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01676">
        <property type="entry name" value="Metalloenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001492">
        <property type="entry name" value="IPGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64158">
        <property type="entry name" value="2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metalloenzyme" evidence="13">
        <location>
            <begin position="17"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="BPG-independent PGAM N-terminal" evidence="14">
        <location>
            <begin position="95"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="468"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="468"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="9">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="166"/>
            <end position="167"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="282"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="425"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="496"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF06415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG5465256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="553" mass="60642" checksum="7E83735FEDDB7C34" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G3S2</accession>
    <name>A0A836G3S2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dynein regulatory complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LSCM4_03740</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
            <location evidence="8">Cytoskeleton</location>
            <location evidence="8">Flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DRC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061673.1">
        <property type="nucleotide sequence ID" value="XM_067205736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G3S2"/>
    <dbReference type="SMR" id="A0A836G3S2"/>
    <dbReference type="GeneID" id="92359670"/>
    <dbReference type="KEGG" id="loi:92359670"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070286">
        <property type="term" value="P:axonemal dynein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060285">
        <property type="term" value="P:cilium-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003352">
        <property type="term" value="P:regulation of cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039505">
        <property type="entry name" value="DRC1/2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039750">
        <property type="entry name" value="DRC1/DRC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21625:SF0">
        <property type="entry name" value="DYNEIN REGULATORY COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21625">
        <property type="entry name" value="NYD-SP28 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14772">
        <property type="entry name" value="NYD-SP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="4 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0282">Flagellum</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein regulatory complex protein 1/2 N-terminal" evidence="13">
        <location>
            <begin position="27"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="169"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF14772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG5474567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="512" mass="58747" checksum="1C83D43804F2B386" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GC09</accession>
    <name>A0A836GC09_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000022">
        <property type="protein sequence ID" value="KAG5479187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063280.1">
        <property type="nucleotide sequence ID" value="XM_067203821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GC09"/>
    <dbReference type="SMR" id="A0A836GC09"/>
    <dbReference type="GeneID" id="92357755"/>
    <dbReference type="KEGG" id="loi:92357755"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5479187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="561" mass="61183" checksum="62E608857D11830B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GGD7</accession>
    <name>A0A836GGD7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_03205</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">LSCM4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060771.1">
        <property type="nucleotide sequence ID" value="XM_067205219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GGD7"/>
    <dbReference type="SMR" id="A0A836GGD7"/>
    <dbReference type="GeneID" id="92359153"/>
    <dbReference type="KEGG" id="loi:92359153"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359:SF25">
        <property type="entry name" value="CYTOCHROME B5 HEME-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="5">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5471654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="112" mass="12430" checksum="8109F0B5F87DDCCE" modified="2021-09-29" version="1">MSATSSLHFVFKGKNYMVPESFVTKEHPGGKAILMALANTDITEAFEEADHSLDAMEMLEEWCVDVSGTQKAELLKRAEARHAEEDEWRWRSTAIAFSVAAIVAAVVLRKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GGK4</accession>
    <name>A0A836GGK4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">adenylate cyclase</fullName>
            <ecNumber evidence="6">4.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">ATP pyrophosphate-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Adenylyl cyclase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">LSCM4_00341</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Could act as a receptor for an unknown ligand.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP = 3',5'-cyclic AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15389"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="EC" id="4.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the adenylyl cyclase class-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.1" evidence="6"/>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058526.1">
        <property type="nucleotide sequence ID" value="XM_067202425.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836GGK4"/>
    <dbReference type="GeneID" id="92356359"/>
    <dbReference type="KEGG" id="loi:92356359"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000022">
        <property type="entry name" value="Receptor-type adenylate cyclase GRESAG 4, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050697">
        <property type="entry name" value="Adenylyl/Guanylyl_Cyclase_3/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015232">
        <property type="entry name" value="DUF1935"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057398">
        <property type="entry name" value="GRESAG4.1/3_peripasmic_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036310">
        <property type="entry name" value="Smp-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43081:SF1">
        <property type="entry name" value="ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43081">
        <property type="entry name" value="ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09149">
        <property type="entry name" value="DUF1935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25493">
        <property type="entry name" value="Peripla_BP_A-cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101601">
        <property type="entry name" value="Smp-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0675">Receptor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="21" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032571357" description="adenylate cyclase" evidence="21">
        <location>
            <begin position="38"/>
            <end position="1408"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="22">
        <location>
            <begin position="873"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1079"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="1079"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="1100"/>
            <end position="1113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00032597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00032637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAG5464895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1408" mass="150668" checksum="DF4BEC525901D478" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GGZ6</accession>
    <name>A0A836GGZ6_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
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            <taxon>Trypanosomatida</taxon>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
            <dbReference type="EMBL" id="KAG5481872.1"/>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
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            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates M.D."/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5465213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="739" mass="78332" checksum="A0C6BDBA1D3355A6" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GK09</accession>
    <name>A0A836GK09_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATPase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_00728</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AFG1 ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058904.1">
        <property type="nucleotide sequence ID" value="XM_067202803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GK09"/>
    <dbReference type="GeneID" id="92356737"/>
    <dbReference type="KEGG" id="loi:92356737"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005654">
        <property type="entry name" value="ATPase_AFG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040713">
        <property type="entry name" value="ZapE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169">
        <property type="entry name" value="ATPASE N2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169:SF28">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03969">
        <property type="entry name" value="AFG1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5465273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="532" mass="59936" checksum="0ECD1F9119E4ED81" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GLS7</accession>
    <name>A0A836GLS7_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_00951</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059667.1">
        <property type="nucleotide sequence ID" value="XM_067203017.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836GLS7"/>
    <dbReference type="GeneID" id="92356951"/>
    <dbReference type="KEGG" id="loi:92356951"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000211">
        <property type="entry name" value="attractin-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF18">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="63"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="444"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="612"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="951"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1122"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1181"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1309"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1422"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1489"/>
            <end position="1512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1686"/>
            <end position="1717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1827"/>
            <end position="1903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="67"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="451"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="618"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="951"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="967"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="985"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1183"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1212"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1239"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1492"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1686"/>
            <end position="1696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1831"/>
            <end position="1840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1855"/>
            <end position="1866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1892"/>
            <end position="1903"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5467865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1903" mass="204876" checksum="D2E67E70A7011B5E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GLT7</accession>
    <name>A0A836GLT7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase C14 caspase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_01332</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059078.1">
        <property type="nucleotide sequence ID" value="XM_067203387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GLT7"/>
    <dbReference type="SMR" id="A0A836GLT7"/>
    <dbReference type="GeneID" id="92357321"/>
    <dbReference type="KEGG" id="loi:92357321"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032933286" description="Peptidase C14 caspase domain-containing protein" evidence="3">
        <location>
            <begin position="24"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C14 caspase" evidence="4">
        <location>
            <begin position="63"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="377"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="392"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5466188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="417" mass="45728" checksum="B683507C2F0C6803" modified="2021-09-29" version="1">MPNFLGMLALEAISGLVPILANGLLSVERPPRVDINAGRRLIHTVRPIVPYRAPVPYTGGRVRALFIGINYTGTSHELRGCVNDIRLMLGTLQQITFPISECCILVDDPSFPGFTGMPTRENIIKHMLWLTGDVRPGDVLFFHFAGHGGQTVAARDSEEEYDQCLIPLDHKKYGSILDDDLFLMLVAPLPAGVRMTCVFDCCHSASMLDLPFSYVAPRMGAGGRREYMQQVRRGNFSNGDVVMFSGCTDSGTSADVQNGGHANGAATLAFTWSLLNTRGFSYLSILLKTREELLRSGRLQVPQLTSSKPIDLYKPFSLFGMVTVNENMMQYVPQQYRRPPQYLPPQAMPPPAGYPAYAPPPPQGYYPQPRQVWGPGVAVQGIPLQQGDPVAPHGPPPPQYASAPPPPQYSFSTVLPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GMC1</accession>
    <name>A0A836GMC1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA polymerase epsilon catalytic subunit</fullName>
            <ecNumber evidence="15">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">LSCM4_01639</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="15">DNA polymerase II participates in chromosomal DNA replication.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="15"/>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059378.1">
        <property type="nucleotide sequence ID" value="XM_067203687.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836GMC1"/>
    <dbReference type="GeneID" id="92357621"/>
    <dbReference type="KEGG" id="loi:92357621"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008310">
        <property type="term" value="F:single-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006287">
        <property type="term" value="P:base-excision repair, gap-filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045004">
        <property type="term" value="P:DNA replication proofreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05779">
        <property type="entry name" value="DNA_polB_epsilon_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05535">
        <property type="entry name" value="POLBc_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000003">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.342.10:FF:000030">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000010">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1600.10:FF:000006">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013697">
        <property type="entry name" value="DNA_pol_e_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029703">
        <property type="entry name" value="POL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055191">
        <property type="entry name" value="POL2_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670:SF0">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08490">
        <property type="entry name" value="DUF1744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22634">
        <property type="entry name" value="POL2_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01159">
        <property type="entry name" value="DUF1744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 15" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 15" id="KW-0235">DNA replication</keyword>
    <keyword evidence="13 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 15" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="11 15" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase epsilon catalytic subunit A C-terminal" evidence="17">
        <location>
            <begin position="1641"/>
            <end position="1997"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="688"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1294"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="708"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="746"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="1314"/>
            <end position="1333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU365029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM01159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG5466488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="2302" mass="259849" checksum="C1A72A9F1E5E7037" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GNT5</accession>
    <name>A0A836GNT5_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_04779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000023">
        <property type="protein sequence ID" value="KAG5478546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063207.1">
        <property type="nucleotide sequence ID" value="XM_067206760.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92360694"/>
    <dbReference type="KEGG" id="loi:92360694"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="667"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="671"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="729"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5478546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1282" mass="136113" checksum="DF750AAECB26EE5C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GQP6</accession>
    <name>A0A836GQP6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_02748</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060321.1">
        <property type="nucleotide sequence ID" value="XM_067204769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GQP6"/>
    <dbReference type="GeneID" id="92358703"/>
    <dbReference type="KEGG" id="loi:92358703"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5470055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="165" mass="17681" checksum="797C0DC9886EB1B2" modified="2021-09-29" version="1">MGLDIFEIDPTTPHPGVMIDGTTAQRETNGGWVTLRSKTPLSATNHQWAVRILDQGEGADGSGLMIGLLPQLSAPLASATGSKYISELGGWCLSRAGDTYGAWKCDRFSYSTDCVVEFDWDAVTGTLCMVSGNKKGTGHIPGVKESDVLFPAVSMYYLNQKVAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GUD2</accession>
    <name>A0A836GUD2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_01851</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">LSCM4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000022">
        <property type="protein sequence ID" value="KAG5479259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063352.1">
        <property type="nucleotide sequence ID" value="XM_067203893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GUD2"/>
    <dbReference type="SMR" id="A0A836GUD2"/>
    <dbReference type="GeneID" id="92357827"/>
    <dbReference type="KEGG" id="loi:92357827"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000068">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="4">
        <location>
            <begin position="12"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5479259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="106" mass="11498" checksum="0490FD395BF31902" modified="2021-09-29" version="1">MASVSPSETGGTLIAFLQQLRGTLVEIELKNASIVSGEIAYVDANMNTYMTHAKITSKGKNPVEVEEYMVRGSTIRYIIMPESLNTYDVLKQASTRKNGASKKGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GUE3</accession>
    <name>A0A836GUE3_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_01866</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000022">
        <property type="protein sequence ID" value="KAG5479274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063367.1">
        <property type="nucleotide sequence ID" value="XM_067203908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GUE3"/>
    <dbReference type="SMR" id="A0A836GUE3"/>
    <dbReference type="GeneID" id="92357842"/>
    <dbReference type="KEGG" id="loi:92357842"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5479274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="163" mass="19440" checksum="9903BBA1BA1F58F2" modified="2021-09-29" version="1">MFRPTAAQLNTFLTRSVATPPISVIRTGPKWWAEPERMVKHKVMYFTMGIDQLPLRRTAVIQNDLKRFHMCKPPPRIGDTTGYKRSRGAQLTTWYRRIQYQEYHLQHLFVRHMWGLLRMYPGNTTKIQGKADDGYVGYDSVHFHRYNRSPLPFPAREIYERRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GV17</accession>
    <name>A0A836GV17_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_03069</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060639.1">
        <property type="nucleotide sequence ID" value="XM_067205087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GV17"/>
    <dbReference type="SMR" id="A0A836GV17"/>
    <dbReference type="GeneID" id="92359021"/>
    <dbReference type="KEGG" id="loi:92359021"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101031">
        <property type="term" value="C:protein folding chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051966">
        <property type="entry name" value="RPAP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46423">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46423:SF1">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5470373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="225" mass="24154" checksum="14FCEBC5D5C94BC5" modified="2021-09-29" version="1">MNTRQTQVVCVTVVVGGLLGALSYAAYRQMSQKRAGSLAGKPNALGSHAHVPTVDDLAQASPPPPPAPPFPLPIESPYPEADKAKALELLNMLKQNANIAFQEGRFEDALRGYQDCIEVTSVLGAADAEAVETEQIVRANVAMVCIRMHEYDAARAVATMLLQDAAVALPDDLKVKVLYRRGLASKALNDRAAALADFNAALHFSKDHKNPAVEKEMALLRRADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GVF5</accession>
    <name>A0A836GVF5_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_05852</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063555.1">
        <property type="nucleotide sequence ID" value="XM_067207782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GVF5"/>
    <dbReference type="SMR" id="A0A836GVF5"/>
    <dbReference type="GeneID" id="92361716"/>
    <dbReference type="KEGG" id="loi:92361716"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032872478" evidence="2">
        <location>
            <begin position="32"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5479844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="293" mass="31107" checksum="4CD9FB4ACC1E6B5C" modified="2021-09-29" version="1">MPLTGWASHARLHAVRLSLISVCHLSSGVSARVASSSVFAAHYGQQRALLAVSTTVHLLKTKKHGAKAAQEKADTVTPPHASFYKSRSMRPAPATTSSIEGAPPPVSSSSSTAGMKASPPPGTNTAAPQPVPEPSLPMAAHDADRSRRSYTPTSAAVNEQFASLRRELVETRLQLAKAEETNAGLYEGVLARLSETDRAAHLTALSLRYTGMALRAAHDNLEVELRRLLTIGLTAEEVDAAAIEAGARQYVRQNIGYHSEHVAAEPSAVPDMARVMGRDERKAAAGVFEKSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GVK3</accession>
    <name>A0A836GVK3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Copine i-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_03867</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the copine family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061798.1">
        <property type="nucleotide sequence ID" value="XM_067205861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GVK3"/>
    <dbReference type="SMR" id="A0A836GVK3"/>
    <dbReference type="GeneID" id="92359795"/>
    <dbReference type="KEGG" id="loi:92359795"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04048">
        <property type="entry name" value="C2A_Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04047">
        <property type="entry name" value="C2B_Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037768">
        <property type="entry name" value="C2B_Copine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045052">
        <property type="entry name" value="Copine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010734">
        <property type="entry name" value="Copine_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857:SF106">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857">
        <property type="entry name" value="COPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07002">
        <property type="entry name" value="Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="113"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="4">
        <location>
            <begin position="275"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5474692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="508" mass="56043" checksum="22410346E91C5527" modified="2021-09-29" version="1">MASMRATVHIFIKCAHLLDKDVMSKSDPYAILFETTDGKKVCVGRTEVIRNNLNPEFKTCIPVNYFFEIRQTMRVEVWDSDKGKADDLLGGAEFTVGQLMSSRGSALTLSLGRKSTVTLTATYVGSYRGTVGVCFRGRDLKKMDLLGKSDPYFILSRLLPSGQQVTLYKSEVIKNTLNPQWKCTRPIDLMDLCGGDILPPCIYFQCFDEDPGTNESMGSFVLTGEQLLASSGREFELTAEKKGKRKSYGFIVVDRCDYVKSYDFVEYLQAGMEINIAFSIDFTGSNGPPSDPRSLHFYHPYQPNSYVRAMLAVSNVVQEYDRDRRFPAFGFGAVAPFTNGTSHFFPLSGNPANAYLNGMQAVVDTYARLLPALQFSGPTNFAPTIRAMTAGARQARGVYTILLILTDGAITDMQDTIDAIVAADDAPLSIVIIGIGYADFSSMVQLDGDGGVLVDRSRRPARRDLVQFVPFNAFEGKDPARLAAAVLLEIPSQVEMWARIVQAIPGRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GW02</accession>
    <name>A0A836GW02_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_00646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058824.1">
        <property type="nucleotide sequence ID" value="XM_067202723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GW02"/>
    <dbReference type="GeneID" id="92356657"/>
    <dbReference type="KEGG" id="loi:92356657"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5465193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="146" mass="15975" checksum="C083973CB72CF73B" modified="2021-09-29" version="1">MDSSPQPPRSRRKRSPRRADAPVVSVFDLPSAEELYRRVTVEYSTRAQLMEEQRSWLAALSNGAAPLKPPAHPFAGSLFGPRPSHTNRSHHEVLLKVESAAMVAQRLAHLTSYPAPSVVETRVLDSAAAEAVSALHSIVCHPPRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GX65</accession>
    <name>A0A836GX65_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LSCM4_01601</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
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                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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                <person name="Bates M.D."/>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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        </source>
    </evidence>
    <sequence length="470" mass="50815" checksum="791E12D0A963CF97" modified="2021-09-29" version="1">MTANSDDQLDALVDSILKSRDRPAITSQLPQRPSSQQQQQSIPASASSRSCGWSINKTTSTRHREHASSGSRNSSVRASMYAVCPGGSTSSAADNFVTAVPTDSRESASSSKTAPTHIDAGDEEAAEEEELSVLIERILAGDGARGLPSTSGPMRHTQESQRAPPSALSTSSPNFSYVPPPHVGSSGPSRASRRGGATRVGERSRSMSRMFGARDVSPDACTQGVVRRLALWYECKEAKRVQAVYEALEREQQECTFQPNINRFEVGVGSSLVADEALHRPSATSKGRQGSGSRSVSFANTISMSSSSSRATPHMCDYIPSLQPPLQPITGADAFVERLRRAWEKRDAVREAEEAKRLHYYDPATFRRDPTVPVPFELGARPRRLLVETAAVVNARSPSPGVVVGVARASPPPPLEEDVFCDVDEGKRLTPENTFLSLAPKIRQGLLFDRQMDTQLLRATDSIRRAAGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GZD1</accession>
    <name>A0A836GZD1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphonopyruvate decarboxylase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_03911</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061841.1">
        <property type="nucleotide sequence ID" value="XM_067205904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GZD1"/>
    <dbReference type="SMR" id="A0A836GZD1"/>
    <dbReference type="GeneID" id="92359838"/>
    <dbReference type="KEGG" id="loi:92359838"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051818">
        <property type="entry name" value="TPP_dependent_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42818:SF1">
        <property type="entry name" value="SULFOPYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42818">
        <property type="entry name" value="SULFOPYRUVATE DECARBOXYLASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="5">
        <location>
            <begin position="17"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="4">
        <location>
            <begin position="256"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5474735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="413" mass="44171" checksum="D024DB932D7CDE22" modified="2021-09-29" version="1">MRCCRRALEGHAKLSPEHVARSLKRHGTSAFFGMPDQYLCPLTSYLADTTAAGEYVMATNCGNAMAIAAGHYLSTRRIPCVFMQNSGIGDAVNPLLTLFHQDAYRMPCLMLISWRGKLDAADELLKPGLVAQGRLTEQCLAAVGVPYSIVGNSRDVEMSWDVTMDKAYYHFASAKTPFAVLLEPGTLVPYTQRRPDADTLPVAPLGHDAVADQVCRQFNATDVFVCSCGSVQESLRRARSTVCGDTAAQDLLLADSLGHATGVATGIALSRPSLQVVCIEGDGAALLHLNAMATNGGLKAITNPTGAGLLHNLKHIVVNDGSYSLEGGQVTAAFDASLTGVAKACGYFAVREEPVIELGDLVAALAELRQCDGPAFLEVVVSQARTSTADGKVRRDLQREKLRFVEFLNRPNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H041</accession>
    <name>A0A836H041_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ADP-ribosylation factor-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_02157</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061229.1">
        <property type="nucleotide sequence ID" value="XM_067204192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H041"/>
    <dbReference type="SMR" id="A0A836H041"/>
    <dbReference type="GeneID" id="92358126"/>
    <dbReference type="KEGG" id="loi:92358126"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04155">
        <property type="entry name" value="Arl3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002056">
        <property type="entry name" value="ADP-ribosylation factor-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044612">
        <property type="entry name" value="ARL2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45697">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="21"/>
            <end position="28"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="125"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5472833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="179" mass="20087" checksum="FC6493E31D5193DE" modified="2021-09-29" version="1">MLRGLRNRMKRENEPRVLILGLDNAGKTTILNKLGVAEEHPIEAPEGPTQGFNVMDVNRGGKRAKLCDLGGQRALREFWEDYYANTDCIMYVVDSSDQRRLREAHEAFVDVVKGVPNVPLLVLANKQDLATAKDPQTVAEALELSDYRDRRWHIQGCSAKSGDGLEEGVAWIFEACNVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H2C1</accession>
    <name>A0A836H2C1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(+) diphosphatase</fullName>
            <ecNumber evidence="4">3.6.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_06552</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60876"/>
            <dbReference type="Rhea" id="RHEA-COMP:15698"/>
            <dbReference type="Rhea" id="RHEA-COMP:15719"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:144029"/>
            <dbReference type="ChEBI" id="CHEBI:144051"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:60877"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. NudC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.22" evidence="4"/>
    <dbReference type="EMBL" id="JAFHLR010000010">
        <property type="protein sequence ID" value="KAG5485596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065180.1">
        <property type="nucleotide sequence ID" value="XM_067208469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H2C1"/>
    <dbReference type="SMR" id="A0A836H2C1"/>
    <dbReference type="GeneID" id="92362403"/>
    <dbReference type="KEGG" id="loi:92362403"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006742">
        <property type="term" value="P:NADP+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03429">
        <property type="entry name" value="NUDIX_NADH_pyrophosphatase_Nudt13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050241">
        <property type="entry name" value="NAD-cap_RNA_hydrolase_NudC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049734">
        <property type="entry name" value="NudC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015376">
        <property type="entry name" value="Znr_NADH_PPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001299">
        <property type="entry name" value="PRK00241.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904:SF6">
        <property type="entry name" value="NAD-CAPPED RNA HYDROLASE NUDT12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904">
        <property type="entry name" value="NUDIX HYDROLASE, NUDC SUBFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09297">
        <property type="entry name" value="Zn_ribbon_NUD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="10">
        <location>
            <begin position="174"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5485596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="331" mass="36463" checksum="C11C6A89ACFB2F43" modified="2021-09-29" version="1">MRSRSSLLPLPLGQAIMRRHERERRSEGFIARHVGPAAESCAVVCKEDGTKVLLNGDAASWLHPIPPRGAHLFLTVPLTQAVYVGEATAQPCNVFVVGEKEVHCEYARHRDWVSPMTVLPSLSPTDHSLLSLALSMKQWASTTLFCARCGGAMHSVDYGMTRDCTSCKHRIYPAVTPAIIVAVLDGKGNVIMSERRKTGATPSSEGSRACLTILAGFVAQGESMEEAVLREVMEEAGARVTSLRYVGSQPWPFPYQLMACYYAVADDSPHLVAEESELAQVRWMSREEVRKALIGEHAEFVTSPPGTATNLLLEEWVRGRVDDWGRPIRHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H3T1</accession>
    <name>A0A836H3T1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">serine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Seryl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_05942</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="2"/>
    <dbReference type="EMBL" id="JAFHLR010000011">
        <property type="protein sequence ID" value="KAG5485309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065046.1">
        <property type="nucleotide sequence ID" value="XM_067207872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H3T1"/>
    <dbReference type="SMR" id="A0A836H3T1"/>
    <dbReference type="GeneID" id="92361806"/>
    <dbReference type="KEGG" id="loi:92361806"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000026">
        <property type="entry name" value="Seryl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.40:FF:000007">
        <property type="entry name" value="Seryl-tRNA synthetase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="entry name" value="Serine-tRNA synthetase, tRNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="tRNA-binding arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="11">
        <location>
            <begin position="170"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="295"/>
            <end position="297"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="311"/>
            <end position="314"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="384"/>
            <end position="387"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="423"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for serine binding" evidence="9">
        <location>
            <position position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5485309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="474" mass="52631" checksum="460A81BCC0AC84E5" modified="2021-09-29" version="1">MGLDIQLFRDPETANVVRESERRRYANPGVVDEIIEIDRRWRRTQFLTEASKKMINTCSKAVGAKKKAKEADGDNSEVPADVMGAAQEGTLDAEKLASLCILQLKELSKALTAQVEGLAKLAAEQEAERDRMVAGVGNILHESVPVSNDEDTGNVVVRTFGDVTRRAKMTHVDCMERLGLMDTSKTVTAMAGGRSFVLRGGLVQLQFALISYALNFLIARGYEPFYPPFFLNREHMAAVAQLSDFDESLYKVSGDGDEKYLIATSEAPIAAYHTNKWFTEMKEPIKYAGISTCFRKEAGAHGRDTLGIFRVHQFDKLEQFVVCSPREDQSWKMLEEMIQTSQDFNESLGLPYRVINICSGALNNAAAKKYDLEAWFPGSGAFRELVSCSNCTDYQARGVNCRFGPNTKGTAANNTKEYCHMLNGTLCAVTRTMCCICENYQTEEGIVIPEALRPFMMGTEILRFPTEAPAAENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H3W0</accession>
    <name>A0A836H3W0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glucose-regulated protein 78</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_03868</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061799.1">
        <property type="nucleotide sequence ID" value="XM_067205862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H3W0"/>
    <dbReference type="GeneID" id="92359796"/>
    <dbReference type="KEGG" id="loi:92359796"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000016">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="271"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5474693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="392" mass="43476" checksum="0D7FE0D94521643C" modified="2021-09-29" version="1">MMKFFVDGLKRKQNIDVSKDQKALARLRKACEAAKRQLSSHPEARVEVDSLVEGHDFSEKITRAKFEELNMVLFKNTLVPVQKVLEDAKLKKSDIDEIVLVGGSTRIPKVQQLIKDFFGGKEPNKGINPDEAVAYGAAVQAAVLTGESEVGGKVVLVDVIPLSLGIETVGGVMTKLIERNTQIPTKKSQVFSTYQDNQPGVLIQVFEGERQMTKDNRLLGKFELSGIPPAPRGVPQIEVAFDVDENSILQVTASDKSSGKREEITITNDKGRLSEEEIERMVREAAEFEDEDRKVRERVEAKNSLESIAYSLRNQVNDKEKLGGKVDAEDKKAIEEAVKEALDFVDENPNADREEYEAAREKLQSVTNPIIQKVYQATGDAGSSEAEAMDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H3X0</accession>
    <name>A0A836H3X0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Haloacid dehalogenase-like hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_03883</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the HAD-like hydrolase superfamily. Cof family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061814.1">
        <property type="nucleotide sequence ID" value="XM_067205877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H3X0"/>
    <dbReference type="SMR" id="A0A836H3X0"/>
    <dbReference type="GeneID" id="92359811"/>
    <dbReference type="KEGG" id="loi:92359811"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000150">
        <property type="entry name" value="Cof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00099">
        <property type="entry name" value="Cof-subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47267">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47267:SF4">
        <property type="entry name" value="PYRIDOXAL PHOSPHATE PHOSPHATASE YIGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01140">
        <property type="entry name" value="C2.B:_Phosphomannomutase_and_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01229">
        <property type="entry name" value="COF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5474708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="32220" checksum="46661E3E2BF0ED1E" modified="2021-09-29" version="1">MEARPYIAVASDMDGTFLSPDHRVSAYTQKIVHKLHHERQVPFILATGRHHTDVLATKQQIKLDGYMVTSNGARAHDPQGNLILKQDMDPSIAQKLACIAADWEDITTCIYQDDHWYVNRKTEDSAEHHQDSAEVLYPHLFDPESFDNYKGVYKVYYSSNNYALLEVLEQKIKGSYSHAVCVAYSLPDCMEVMAISVNKGMALAQVLKGFIFPNDTRSGEELLKACICFGDGENDVQMLMMAGTGCIMGNAQDRLLNALPLGKDPHLQVIGSNAHDGVAKKLAEVFQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H433</accession>
    <name>A0A836H433_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_04458</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062651.1">
        <property type="nucleotide sequence ID" value="XM_067206442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H433"/>
    <dbReference type="SMR" id="A0A836H433"/>
    <dbReference type="GeneID" id="92360376"/>
    <dbReference type="KEGG" id="loi:92360376"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="92"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="172"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="267"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="284"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="362"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="375"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5477240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="434" mass="46948" checksum="0025C10A3E724181" modified="2021-09-29" version="1">MPAKQKKGRGKTVNLFEFNEDYIPEEALDWAEDDWMTAEQVGEAKLSEKLAKQRQEYSRVANNALDQQESFRTAAMSAQKKCFTIDDLQPPYVAHFGNLRNGTTEEDFLSLFNREAIATHRLINQDGKSFAFVEFVSAQALTVALSLDQTFQRGRRMYVDLATQKQVERLLNRNTNERPGISRDLTGQQQPGGLAAMGLSRDVFGGQQPEDQPGMPTMGNRSNFGSRADLHSLSDLSRDMLGSAVQQASPTSGSPMCGAGYPLNLRNWRSDAPEQQPDFSIPRENGRSEDSVDRRASNLRRSSGQASPAATPVPPEPKPNPFAGEVGNWRDAPRAEAPKMEIPAVAAEGDATAPSERKTEESNAGAASSPSSNGRGRGGGRGGRGGAGIGDRSSFGGDRSGFGGERSGFAGERIAPPKPSGPVSTDKWADLRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H5A2</accession>
    <name>A0A836H5A2_9TRYP</name>
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        <recommendedName>
            <fullName evidence="1">NTF2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063488.1">
        <property type="nucleotide sequence ID" value="XM_067207715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H5A2"/>
    <dbReference type="GeneID" id="92361649"/>
    <dbReference type="KEGG" id="loi:92361649"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059006">
        <property type="entry name" value="NTF2_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26533">
        <property type="entry name" value="NTF2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTF2-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5479777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="148" mass="17065" checksum="C12C1C2FFAFDFC57" modified="2021-09-29" version="1">MSYSGRKLKYFVDDSDGWLRRNQQVAKQFVMAEDDRETKEMLSLMAPRAHFASFWGVVRGLPAAVALQAQEREHLRITWTSGLQTLTSHTFVRKGYVHVLDKGRMAAIPVLGPWLSSFFQRAVHEFLVVREGEVVFRSLGYVWDIGKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H5C4</accession>
    <name>A0A836H5C4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063518.1">
        <property type="nucleotide sequence ID" value="XM_067207745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H5C4"/>
    <dbReference type="SMR" id="A0A836H5C4"/>
    <dbReference type="GeneID" id="92361679"/>
    <dbReference type="KEGG" id="loi:92361679"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF3">
        <property type="entry name" value="N-TERMINAL KINASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="697"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="768"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="835"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="779"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="796"/>
            <end position="807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5479807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="856" mass="88579" checksum="43CE2AF34AC6DA2F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H5P3</accession>
    <name>A0A836H5P3_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5478050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062957.1">
        <property type="nucleotide sequence ID" value="XM_067207389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H5P3"/>
    <dbReference type="GeneID" id="92361323"/>
    <dbReference type="KEGG" id="loi:92361323"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="742"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="858"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="350"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="755"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="861"/>
            <end position="873"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5478050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="991" mass="104414" checksum="401179577511A949" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H5Z3</accession>
    <name>A0A836H5Z3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calpain catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_03129</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060698.1">
        <property type="nucleotide sequence ID" value="XM_067205146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H5Z3"/>
    <dbReference type="SMR" id="A0A836H5Z3"/>
    <dbReference type="GeneID" id="92359080"/>
    <dbReference type="KEGG" id="loi:92359080"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015232">
        <property type="entry name" value="DUF1935"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036310">
        <property type="entry name" value="Smp-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF423">
        <property type="entry name" value="LEUCINE-RICH REPEAT PROTEIN (LRRP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09149">
        <property type="entry name" value="DUF1935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101601">
        <property type="entry name" value="Smp-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="3">
        <location>
            <begin position="411"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="140"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5471581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="944" mass="103034" checksum="CBA5643B78F36C63" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H6E8</accession>
    <name>A0A836H6E8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome c oxidase assembly factor-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_06158</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">LSCM4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SCO1/2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000020">
        <property type="protein sequence ID" value="KAG5480392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063723.1">
        <property type="nucleotide sequence ID" value="XM_067208083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H6E8"/>
    <dbReference type="SMR" id="A0A836H6E8"/>
    <dbReference type="GeneID" id="92362017"/>
    <dbReference type="KEGG" id="loi:92362017"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02968">
        <property type="entry name" value="SCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000459">
        <property type="entry name" value="Cytochrome c oxidase assembly factor-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003782">
        <property type="entry name" value="SCO1/SenC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151:SF3">
        <property type="entry name" value="C OXIDASE ASSEMBLY FACTOR, PUTATIVE ELECTRON TRANSPORT PROTEIN SCO1_2, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151">
        <property type="entry name" value="ELECTRON TRANSPORT PROTIN SCO1/SENC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02630">
        <property type="entry name" value="SCO1-SenC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="3">
        <location>
            <begin position="119"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR603782-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR603782-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5480392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="32647" checksum="39A411A66AD955AA" modified="2021-09-29" version="1">MQSLRKLQHRLFLQSVSTEGPSYTRWKYRPRSKAEFWGLVSGASVFPISVFIINWYENRRLEKPDLAPDFQSLQFVSLKPKTQLGGPFRLRESRTGKYITNDELFQNKWTLLYFGFSKCAEVCPSTLTFISNVMKACDAKYGCRPDLAAEEKMLQAAFLSIDFIRDTPEVVEQFVRKYDPRVRGMCGTREEVEAAARVWRVYYSSVDDTEEERDAREAAGVAAPEIDDTYQFDHSNAIYLVGPDGKMKDFFFKEMGLEDTVSRIGIHFTDVYGFSDTRQAPMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H849</accession>
    <name>A0A836H849_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061192.1">
        <property type="nucleotide sequence ID" value="XM_067204155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H849"/>
    <dbReference type="GeneID" id="92358089"/>
    <dbReference type="KEGG" id="loi:92358089"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="572"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="815"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="584"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5472796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="888" mass="95052" checksum="323E634C5C8F9C1F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H8W8</accession>
    <name>A0A836H8W8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063441.1">
        <property type="nucleotide sequence ID" value="XM_067207668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H8W8"/>
    <dbReference type="GeneID" id="92361602"/>
    <dbReference type="KEGG" id="loi:92361602"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031930">
        <property type="term" value="P:mitochondria-nucleus signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47936:SF1">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN GUN1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47936">
        <property type="entry name" value="PPR_LONG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5479730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="735" mass="81885" checksum="6C2306FA93757AE2" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H921</accession>
    <name>A0A836H921_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000017">
        <property type="protein sequence ID" value="KAG5481802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064162.1">
        <property type="nucleotide sequence ID" value="XM_067208788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H921"/>
    <dbReference type="GeneID" id="92362722"/>
    <dbReference type="KEGG" id="loi:92362722"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5481802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="110" mass="12076" checksum="ECBB7938E701B988" modified="2021-09-29" version="1">MVASRRHTKLSPGAIVLREESACNVGMQHTANDTAADNIGRKKLVDELNATKKMLWAAEDIILDERILAARLERQHLPGGPSLLLSFSLFCNFCAVVGICCLLQRRTSQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H9I3</accession>
    <name>A0A836H9I3_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061519.1">
        <property type="nucleotide sequence ID" value="XM_067205582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H9I3"/>
    <dbReference type="GeneID" id="92359516"/>
    <dbReference type="KEGG" id="loi:92359516"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5473516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="360" mass="40510" checksum="C9E6E2B4027305D7" modified="2021-09-29" version="1">MILCSARRLVGKTAVAAARHEVPNGAHTSYESRPSTSMSSSGTTDAGATAAACSPIATSASTSWMAGAAWASLGSEFKSVAEEKFLKPVPDRFLTPRATTDIQPAEELLTKLVAENAERYKGIDVRDPSSMAIYEGERPRWMTMGGQVRAVSEFISGHLCHHISLPEWKDLFDLEYAEMDLTYWLYVLHVHLVSRRATSIPIDKFNRRREVLEELLMTMFDGWAATSEDIMGRPPLNKIKYYIRDMYYVTAVNFEEALLHDGPGADMMLMGFLMKFCPLPRPEDVPMFTYYTLVHYVRFHTALFDRIPDEEFAKGNFNFLSPTDPLIFSKYSDVAYDEVIRGWTVEEEVGDADAAAPRHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HF79</accession>
    <name>A0A836HF79_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Dynein heavy chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">LSCM4_04335</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062258.1">
        <property type="nucleotide sequence ID" value="XM_067206321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HF79"/>
    <dbReference type="GeneID" id="92360255"/>
    <dbReference type="KEGG" id="loi:92360255"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1220:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000001">
        <property type="entry name" value="dynein heavy chain 7, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.280:FF:000001">
        <property type="entry name" value="dynein heavy chain 7, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.20:FF:000001">
        <property type="entry name" value="dynein heavy chain 7, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000362">
        <property type="entry name" value="Dynein, axonemal, heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878:SF70">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 2, AXONEMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="8 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain ATP-binding dynein motor region" evidence="15">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain region D6 P-loop" evidence="14">
        <location>
            <begin position="436"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA lid" evidence="16">
        <location>
            <begin position="589"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain C-terminal" evidence="17">
        <location>
            <begin position="736"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="174"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF12781"/>
        </source>
    </evidence>
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        <source>
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            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000014">
        <property type="protein sequence ID" value="KAG5483765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067206895.1"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
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        <property type="entry name" value="DNA/RNA_pol_sf"/>
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        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
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    </dbReference>
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            <begin position="1467"/>
            <end position="1710"/>
        </location>
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        <location>
            <begin position="109"/>
            <end position="173"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1184"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1332"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5483765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1757" mass="191319" checksum="D22FDBE27F3357DE" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HJN1</accession>
    <name>A0A836HJN1_9TRYP</name>
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        <recommendedName>
            <fullName evidence="2">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">LSCM4_05290</name>
    </gene>
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        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5477898.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067207237.1"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:ubiquitin protein ligase activity"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Znf_RING"/>
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        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MYCBP2"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="2">
        <location>
            <begin position="302"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5477898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="547" mass="59453" checksum="085F595D629AE7F8" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HJS9</accession>
    <name>A0A836HJS9_9TRYP</name>
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        <recommendedName>
            <fullName evidence="13">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LSCM4_05520</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5478120.1"/>
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        <property type="nucleotide sequence ID" value="XM_067207459.1"/>
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    <dbReference type="SMR" id="A0A836HJS9"/>
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    <dbReference type="KEGG" id="loi:92361393"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009160">
        <property type="entry name" value="Acyl-CoA_deSatase_haem/ster-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF31">
        <property type="entry name" value="DESATURASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000345">
        <property type="entry name" value="OLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="13">
        <location>
            <begin position="380"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG5478120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="431" mass="49098" checksum="28E765B6CD3B107B" modified="2021-09-29" version="1">MTSVEMKDKAVAKEPMRRQPTYQEGNYEINYVAVAVLGLPIAGVLAAVFMGVPLQWKTFVTAVFFYMFNGCLGVTVGYHRLFSHRSYTASTAFQWLCAFAGAGSFEGSAKWWGRNHRIHHRYVDTEKDPYNAQRGFVFSHMGWMIMKQDYSLLGKVDVSDFKYNYVIQFQHKHFFKMAMLSGVILPTIICGLGWGDWLGGYFYASLAKIVFVHHCTFFINSLAHTNLFAAVQNFSDRHSSHDSFVCALFTFGEGYHNFHHEFAQDYRNGIKWYHYDPTKWIIRAVSFVGGAKNLVRTPNDVIDANFNKMLLKKSKKAMEQAQARLNELDIPISTEWTWEKVQDEVAKGRKLTVINNEVIDLMRSIPTGSGYTHRSKDIIWYSNHPGGQRILDMFVGKDATSAFTGGVYAHSCGAEAYLQHLRVAKLKVATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HKB5</accession>
    <name>A0A836HKB5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Alcohol dehydrogenase-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_07480</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000004">
        <property type="protein sequence ID" value="KAG5487802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065999.1">
        <property type="nucleotide sequence ID" value="XM_067209367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HKB5"/>
    <dbReference type="GeneID" id="92363301"/>
    <dbReference type="KEGG" id="loi:92363301"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08290">
        <property type="entry name" value="ETR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000040">
        <property type="entry name" value="Nuclear receptor binding factor-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051034">
        <property type="entry name" value="Mito_Enoyl-ACP_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981:SF5">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="8">
        <location>
            <begin position="46"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="427"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5487802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="450" mass="50793" checksum="2D83B34CF196897F" modified="2021-09-29" version="1">MRPSRKLSGLPNVRTVAATGWRYHRHGPPKRVLQYERYRIPFDRTSGQVVVKMLAAPVHRHDKSLIEGHGGPIAVLKTCLPHVAGVEGVGVVEEVGSNAKLALKEGDMVWINNPAVGSWATHIVTDAENLDVVPCRADVDIEYLSSLSLFHTAYHLTHDFVSIQPNDVVLQTGASSSIAQICQGYLRAKGAKLFQTMQLGRTEHAHLLAFFKLRGAFAVVPYNYARTNYMRRLLSDVPPPKLLLNHTCGGYASNLIHLLGDNGVCVTYGNTSHQPMQIANTDAIARGIRFKGFFLPRWMQRHTREARMRVHQNVVESMTITQGHGIFRAQRFKMDGDSEFAFSNAWDAPLASRKAVLRMVGEYGEWRRPRSDQAGWNIGRAVWEDMLQQMWESAGTSENPQSMKYYTPFDDINSSFYDAKQSKEMGHRDVFFRRPNAPRHNAAEQQQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HLT8</accession>
    <name>A0A836HLT8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_04860</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000014">
        <property type="protein sequence ID" value="KAG5483708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064647.1">
        <property type="nucleotide sequence ID" value="XM_067206838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HLT8"/>
    <dbReference type="GeneID" id="92360772"/>
    <dbReference type="KEGG" id="loi:92360772"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF458">
        <property type="entry name" value="SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="415"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="476"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="511"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="543"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="586"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="630"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="655"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="693"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="10">
        <location>
            <begin position="342"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="152"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5483708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="730" mass="78079" checksum="1C3C4635DB6807A6" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HND0</accession>
    <name>A0A836HND0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Medium-chain specific acyl-CoA dehydrogenase, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_07795</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000006">
        <property type="protein sequence ID" value="KAG5487305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065802.1">
        <property type="nucleotide sequence ID" value="XM_067209672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HND0"/>
    <dbReference type="SMR" id="A0A836HND0"/>
    <dbReference type="GeneID" id="92363606"/>
    <dbReference type="KEGG" id="loi:92363606"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070991">
        <property type="term" value="F:medium-chain fatty acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051793">
        <property type="term" value="P:medium-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000001">
        <property type="entry name" value="Acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000010">
        <property type="entry name" value="Medium-chain specific acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000011">
        <property type="entry name" value="Medium-chain specific acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF2">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016578">
        <property type="entry name" value="HsaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0274">FAD</keyword>
    <keyword evidence="4 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="10">
        <location>
            <begin position="46"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="9">
        <location>
            <begin position="161"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="8">
        <location>
            <begin position="263"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5487305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="416" mass="45065" checksum="0B8C281C8712A589" modified="2021-09-29" version="1">MRATRKGMLARCTAPLRAAKSADSGVFFGASMPAVQSATGLSFGLTEQQLRYQETARSFAAEKMIPVAAEYDKSMAYPHEVYRQAWELGLTNMHIPEKYGGLGASVVDGLVVQEELAYACSGMATAFEGNSLAEAPLLIAGTDAQKQKYLCRMVEEPLLAAYCVTEPTGGSDVAGMKTVAKKEGDKWVINGSKMWITNGGVANWYYVLARSEGGYTGFIVDADAPGVTRGAKEVMLGQRCSDTRGITFENVVVPEENVVGEVGKGFQVAMKVFDFTRSSVAISAVGLSRRATDEATKYARERVTMGKPIAQHQAVAFMLAEMAAGVEACRLITYRAGWDTDQGRRNTYYASCAKMMAADLAEKCSTNAVQILGGNGYNTGYPVEKLYRDCKIFSIYEGTTQIQHAIISRYVTGMRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HPQ7</accession>
    <name>A0A836HPQ7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000017">
        <property type="protein sequence ID" value="KAG5481901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064261.1">
        <property type="nucleotide sequence ID" value="XM_067208887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HPQ7"/>
    <dbReference type="GeneID" id="92362821"/>
    <dbReference type="KEGG" id="loi:92362821"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052220">
        <property type="entry name" value="METTL25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12496">
        <property type="entry name" value="CGI-41 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12496:SF0">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13679">
        <property type="entry name" value="Methyltransf_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="748"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5481901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1049" mass="115095" checksum="0807388FB21D33A8" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HQE5</accession>
    <name>A0A836HQE5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Folate/biopterin transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_06584</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Folate-biopterin transporter (TC 2.A.71) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000010">
        <property type="protein sequence ID" value="KAG5485628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065212.1">
        <property type="nucleotide sequence ID" value="XM_067208501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HQE5"/>
    <dbReference type="GeneID" id="92362435"/>
    <dbReference type="KEGG" id="loi:92362435"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039309">
        <property type="entry name" value="BT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004324">
        <property type="entry name" value="FBT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00788">
        <property type="entry name" value="fbt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31585">
        <property type="entry name" value="FOLATE-BIOPTERIN TRANSPORTER 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31585:SF51">
        <property type="entry name" value="TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03092">
        <property type="entry name" value="BT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="202"/>
            <end position="220"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="441"/>
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        <location>
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        <location>
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        <location>
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            <begin position="1"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00007015"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="674" mass="73328" checksum="A192270696ABF1D5" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
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</entry>
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                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </source>
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            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    <sequence length="478" mass="53590" checksum="42D589B1E7084996" modified="2021-09-29" version="1">MPVPASPNTSDSREIEYRKHLSFTHTLKIVIRNGIYAAIGRVLIGIVKALVKRGLSRALLARIPSELLSLDPLKWAAVFGGFSSFRFCLQTLVRILTPLGVSEKFLSLFAGCISATPAFVMNKETRTELSLYLFVRSAHTFSLRYLLPRMPKILQEFRHYDVFLMCLSSAQIAHGCLFDPNTLPKSYQGFLNRASTYHEKLIRGHSGFCRERLVPDLVDYCWSRQLPVIENFGQRGANTLCQVAHGSYSCNMWAVVFVIRNMLTTGMPLYFPLRLVSMLAFQRRRLMSNPLSTIAHNVRSMLASSLFLALYSGVILRSACFGVQHRGGGTKTVTALCSLAGLATLLEPKGRRMDLALYCSMYALRSFLLTQNLRGRLPYPRHWFVCTVYLLSVGFLFYQYEEEPRLLDRRVRTALRLLLGEQSTVVLAEKEMPTLATVAMSACDAVEAPAESAAASKNKEKRVQVANTVSFASARQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836HT27_9TRYP</name>
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        <recommendedName>
            <fullName evidence="9">U3 small nucleolar RNA-associated protein 25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_04868</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Discoba</taxon>
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            <taxon>Trypanosomatida</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UTP25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000014">
        <property type="protein sequence ID" value="KAG5483716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="KEGG" id="loi:92360780"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="UTP25"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR053940">
        <property type="entry name" value="UTP25_NTPase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12933">
        <property type="entry name" value="ORF PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12933:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 25 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Utp25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22916">
        <property type="entry name" value="UTP25_NTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UTP25 NTP hydrolase-like" evidence="6">
        <location>
            <begin position="646"/>
            <end position="858"/>
        </location>
    </feature>
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        <location>
            <begin position="870"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="570"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="235"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="270"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="290"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="570"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="605"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="632"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5483716.1"/>
        </source>
    </evidence>
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                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Bates M.D."/>
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            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">O-methyltransferase required for two non-consecutive steps during ubiquinone biosynthesis. Catalyzes the 2 O-methylation of 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid into 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid. Also catalyzes the last step of ubiquinone biosynthesis by mediating methylation of 3-demethylubiquinone into ubiquinone. Also able to mediate the methylation of 3-demethylubiquinol into ubiquinol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-methionine = a 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44452"/>
            <dbReference type="Rhea" id="RHEA-COMP:10930"/>
            <dbReference type="Rhea" id="RHEA-COMP:10931"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64694"/>
            <dbReference type="ChEBI" id="CHEBI:84443"/>
            <dbReference type="EC" id="2.1.1.114"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3-demethylubiquinol + S-adenosyl-L-methionine = a ubiquinol + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="Rhea" id="RHEA-COMP:10914"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:84422"/>
            <dbReference type="EC" id="2.1.1.64"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3-demethylubiquinone + S-adenosyl-L-methionine = a ubiquinone + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:81215"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:19654"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:231825"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of a multi-subunit COQ enzyme complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.64" evidence="5"/>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EC" id="2.1.1.114" evidence="5"/>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059367.1">
        <property type="nucleotide sequence ID" value="XM_067203676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KBS3"/>
    <dbReference type="SMR" id="A0A836KBS3"/>
    <dbReference type="GeneID" id="92357610"/>
    <dbReference type="KEGG" id="loi:92357610"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061542">
        <property type="term" value="F:3-demethylubiquinol 3-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010420">
        <property type="term" value="F:polyprenyldihydroxybenzoate methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000615">
        <property type="entry name" value="Ubiquinone biosynthesis O-methyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00472">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010233">
        <property type="entry name" value="UbiG_MeTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01983">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464:SF19">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS O-METHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 5" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5466477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="295" mass="32642" checksum="7DB5BFE3987AAFF9" modified="2021-09-29" version="1">MSASMKGVAADEVAKFAALQKHWWNPRGPLRSLHLLDPIRVRYINSVVRLYGKSDGRSGNESTNLSSCSGLTPRHQVLDVGCGGGILAESLARVGGTVTGIDVCAESIDVAEKRRQQLAASFSDSSQLSNWPQRLSYRHMSLFDVVEQEKKRFDVVVASEVIEHVNDARAFLQALCEATKPGGLLFLSTIDKSLKTAITHIGVAEMLTGLVEPGTHDWRRFIPPSDVTKFAQRFSVHKVDQQYIVTYPDFFQSMVSHDFQVNFCLSKKINTGHYFWAGLKSSETVAEKTAVPTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KC01</accession>
    <name>A0A836KC01_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Organic solute transporter Ostalpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_00715</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058891.1">
        <property type="nucleotide sequence ID" value="XM_067202790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KC01"/>
    <dbReference type="GeneID" id="92356724"/>
    <dbReference type="KEGG" id="loi:92356724"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="290"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5465260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="372" mass="42502" checksum="B1AED08AB76C51BE" modified="2021-09-29" version="1">MGLFSVLQRWKTERRKMYYWAGTFACVVGLLLFIYIILSTVLKNQSVVPNFVAGYCAIFATLLSCFQILEHLTCFSDPECQTKIVRILFMVPLFAVISSISLLAPGAAEYLNLIRDTYESYVIYAFFQLMMALMGGIDTVYRTLMIEDRPPVRQIFPFCYLEPIKVTPTFVQKCRLCLFQFMLLKPLVTIIVVILTAKDAMGTSMFDLTKGTFWTYLVYNISITVAFTALLYFYMGLKDLIEGRNVFLKFLCVKAVIFLSFWQGLLIQLISAAGLLPTFSYWKAEDTPAALQDLLICVEMMFVAFAHKYCFGSDEYMVNGGADDCVIEDISSQDGLQARNIPPIRYSVAENLKYTLKHEDILMDVRDIVHNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KD21</accession>
    <name>A0A836KD21_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_01034</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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            <end position="463"/>
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            <begin position="508"/>
            <end position="532"/>
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    <feature type="transmembrane region" description="Helical" evidence="2">
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            <begin position="604"/>
            <end position="624"/>
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            <end position="97"/>
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            <end position="28"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="64"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <end position="92"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="EMBL" id="KAG5467947.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="639" mass="71391" checksum="705B0E72513CAE22" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836KET1_9TRYP</name>
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        <recommendedName>
            <fullName evidence="5">Nuclear segregation protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">LSCM4_02660</name>
    </gene>
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        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG5469972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:intracellular mRNA localization"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="487"/>
        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5469972.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KF29</accession>
    <name>A0A836KF29_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nucleoside diphosphate kinase</fullName>
            <ecNumber evidence="9">2.7.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_02982</name>
    </gene>
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        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the NDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="9"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067205001.1"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A836KF29"/>
    <dbReference type="GeneID" id="92358935"/>
    <dbReference type="KEGG" id="loi:92358935"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
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        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11349">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="10">
        <location>
            <begin position="3"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="7">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5470287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="151" mass="16656" checksum="4A37ED6A55B777C6" modified="2021-09-29" version="1">MSSERTFIAIKPDGVQRGLVGEIISRFERKGFKLVAMKILQPTTEQAQGHYKDLASKPFFPGLVEYFSSGPIVCMVWEGKNVVKSGRTLLGATNPADSQPGTIRGDFAVDVGRNVCHGSDSVESAQREIAFWFKPEEIASWTSHSACQIYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KG09</accession>
    <name>A0A836KG09_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061905.1">
        <property type="nucleotide sequence ID" value="XM_067205968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KG09"/>
    <dbReference type="GeneID" id="92359902"/>
    <dbReference type="KEGG" id="loi:92359902"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23244:SF471">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23244">
        <property type="entry name" value="KELCH REPEAT DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="558"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5474799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="835" mass="90729" checksum="DB18D4D5750747F5" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KG42</accession>
    <name>A0A836KG42_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_02129</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061202.1">
        <property type="nucleotide sequence ID" value="XM_067204165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KG42"/>
    <dbReference type="SMR" id="A0A836KG42"/>
    <dbReference type="GeneID" id="92358099"/>
    <dbReference type="KEGG" id="loi:92358099"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="61"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="349"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="500"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5472806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="638" mass="69695" checksum="6084E4D67A3FE06E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KGV6</accession>
    <name>A0A836KGV6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LSCM4_03701</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061634.1">
        <property type="nucleotide sequence ID" value="XM_067205697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KGV6"/>
    <dbReference type="SMR" id="A0A836KGV6"/>
    <dbReference type="GeneID" id="92359631"/>
    <dbReference type="KEGG" id="loi:92359631"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08215">
        <property type="entry name" value="STKc_Nek"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000097">
        <property type="entry name" value="Probable serine/threonine-protein kinase nek1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001310">
        <property type="entry name" value="Putative serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051131">
        <property type="entry name" value="NEK_Ser/Thr_kinase_NIMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899">
        <property type="entry name" value="CAMK FAMILY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="20"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="292"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="324"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG5473631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="507" mass="56845" checksum="524F90343B5AD89A" modified="2021-09-29" version="1">MAQAADETRTLESEVFCSKYRRIKSIGKGSFGEAVLVRSKSDGKRYVAKAIDSVSMSPKERRDVQNEIRILAAVDHPNIIRYHEHFEDGTLIFIIMEYADGGDLSSRIKEAKKHETPQPFDPNLAMFWFLQICMALKYLHDNHILHRDLKTANIFLTSKNVVKLGDFGISTVLQNTMACAKTVCGTPYYFSPELCQSKPYNNKSDVWALGVVFYETLTLHRPFNAKTLKDLLRKILAGSYDPIPTTIPVEMRSLCASLLQVNYMQRPSINRILESSYVQSTLRSFSEDLARQVEKDRTDFEEKQLREREKQDRPPATKAAEATKLPHEPAKPQLSEREQMAMLRGMDREKMKAMLAKQAAEEKSTPTTAAAPEPAIHPDVDDDGDYIAQKKAMVQQSKDIVGKSNLGGHPEEFGDGPADSVPQVETITLANGQTVLASDVRGHLEKEMGAELLDRAVEMYNSCMMSGLSNAEMQHELIELVGAKFAHNSNAITKLAVWEGKQKVFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KH53</accession>
    <name>A0A836KH53_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_01916</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060993.1">
        <property type="nucleotide sequence ID" value="XM_067203956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KH53"/>
    <dbReference type="GeneID" id="92357890"/>
    <dbReference type="KEGG" id="loi:92357890"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034338">
        <property type="term" value="F:short-chain carboxylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050960">
        <property type="entry name" value="AB_hydrolase_4_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794">
        <property type="entry name" value="ABHYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794:SF63">
        <property type="entry name" value="ALPHA_BETA HYDROLASE 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="133"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5472597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="425" mass="46309" checksum="A29AE1505622BCE8" modified="2021-09-29" version="1">MSEAPSAGDTAAPLLCHAPLAAKVKFLCAQVFCFLFVDLFPRLVRFLGGASLATEKTTVFGSLRAKAFFKLDGVDKMPYVDPLYSGHASTILCALRPHRRIPYKRLVHPGADGNPMCVDWLFTEARSAKGVFLIIPGLASWSGTNYIEHFVWFAYTQHFHCAVFNSRGMGDTPIETPRLMSGKWTDDLRAVLRGGPLSRAFIDENCGASLPVIGVGFSLGGVILSKYVGEECLAGRELVMDAVMVVNSPLNCLDSSALMSRGISRVLYQPRMVGGLTAYARRHAKVLGNLPGLSPDVRAAFASGRLEEVLAQMKTVRDFDRFITAPTLGYATPEDYYHHISPTEWLPHFSVPVLCISSADDPVTGKPPMASLSNIMASNPNVALLVIPRGGHLGYARSLRHEWVGAETVMETIIFQVAATVPPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KHJ8</accession>
    <name>A0A836KHJ8_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_05234</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062487.1">
        <property type="nucleotide sequence ID" value="XM_067207184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KHJ8"/>
    <dbReference type="SMR" id="A0A836KHJ8"/>
    <dbReference type="GeneID" id="92361118"/>
    <dbReference type="KEGG" id="loi:92361118"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5476254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="267" mass="29350" checksum="7BF21C66B87879B6" modified="2021-09-29" version="1">MRCRTLPLLGRDALNAGSSMTLGCKGMRPSPEPHRRRMPWTAAKEYVPGVVLNSKEKLVLDGTQLVELDHIDRAAQLDPLEVLKATVATRAYNTSTGFNIFQLASQTRFHGRGQKFFREEWRQGTYDKYVTLAAIDFDREGSKGTAYGYITFHGESTTRPVEVSHADTPGWLMDYDEDAAVPFDAVVPPPPSIGTDVPVDPCNYRLKAYPFYDAPNPPEFVERLLKDRGVLPDLPMDASVPAEDAAAAYADGAGADGSHHYGSKSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KHQ1</accession>
    <name>A0A836KHQ1_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061712.1">
        <property type="nucleotide sequence ID" value="XM_067205775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KHQ1"/>
    <dbReference type="SMR" id="A0A836KHQ1"/>
    <dbReference type="GeneID" id="92359709"/>
    <dbReference type="KEGG" id="loi:92359709"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5474606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="426" mass="45242" checksum="86C0748707B0C66A" modified="2021-09-29" version="1">MSERWDMTGAKNLQMTVAQSVLFLYCDLSKHCGESSSGKSVLISSSCGNKPLGKSGAFLGLNIFAKSLEKRELSSKATEALRSPSFTDVGEGCQWRIEEDDATLCIRIDFATVTKRLGASGKSMLLATTGGNKPIAGTGLMCGLNCYYPVGKTFDASQLAVGNTAEDVLQVGQAHSFEGGFCVLYTAPTEMHVTYTYCAEKMADGHTASLPACCVGDLKVAMFVSAPKAARARTEKTTEKMTGEGQLSTTSSSLTPSLSQLSPTNSSDFLLVESGMDKKVRNVTVTCAPVTAQSAQTPTSSGSRSDAYTIDLRFDPTQSFGRSSSGKCLLVATTGGFQRVVDAEDHIVCRLSLNAYRPAPPLSEEEITTAVQAVLATKPKAQLLSLSFKELLTEVVSVLGLSEPMKEAMKPKIKEAAVAFLQEAAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KHR3</accession>
    <name>A0A836KHR3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_03824</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061757.1">
        <property type="nucleotide sequence ID" value="XM_067205820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KHR3"/>
    <dbReference type="SMR" id="A0A836KHR3"/>
    <dbReference type="GeneID" id="92359754"/>
    <dbReference type="KEGG" id="loi:92359754"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000274">
        <property type="entry name" value="Mitochondrial RNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46565">
        <property type="entry name" value="COLD SHOCK DOMAIN PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46565:SF20">
        <property type="entry name" value="COLD SHOCK DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="2">
        <location>
            <begin position="17"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5474651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="146" mass="15520" checksum="7EAFD742C1994C8B" modified="2021-09-29" version="1">MFRVSSVSRIAPSLVLLNTGKVVSWMSGRGFGFIEDNADKKQHFVHFSALQTETGGYRALAVDQEVEFEVASQDGRTRAENVTGPGGAKLPSGPRPPEGSPGGRGGFGGGRGRGRGGRNYSNNRQDRGGDRDGGRQGNTSNFSDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KHU2</accession>
    <name>A0A836KHU2_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_03917</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061847.1">
        <property type="nucleotide sequence ID" value="XM_067205910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KHU2"/>
    <dbReference type="GeneID" id="92359844"/>
    <dbReference type="KEGG" id="loi:92359844"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5474741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="107" mass="11256" checksum="166671BDF18A0783" modified="2021-09-29" version="1">MLSSHSLAQARAPADVMAGEEAAAIAAGYARGRFTTYYVDCAKLPSSGSTTTSAAPSSTAFSSTVLRGVQTGSIPTLGDFSMLPHPEYANRRGKTLNKPLYIHHLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KHW9</accession>
    <name>A0A836KHW9_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_03488</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061425.1">
        <property type="nucleotide sequence ID" value="XM_067205488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KHW9"/>
    <dbReference type="GeneID" id="92359422"/>
    <dbReference type="KEGG" id="loi:92359422"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5473422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="448" mass="47016" checksum="8FB5058AFFA97F72" modified="2021-09-29" version="1">MQTCISRHHTSRLTLVGTCLGTKVAKAVLMSAAAGRLTPEILGEALISSSTIRGHVQRESVRLLVVRVSMRTPRQLQWLLHLIGDCAGGLSATDALSSLAKRSLFYQVASFGLHGSVASAITTAALHVGITTCTLLTSNVSLWRDEDSRMSLRQYRYEVLTSLYASVGTVAGGAAGAAVGSMVMPGIGTAFGSVLCSVGGGYLPGYLRDKKGPDDRRRQQAVSLRRFTPLRMRDTADGTVLMSMEELTETPSITPALTAAEVSAAPELTQPLQHASGTGAEDGSAGKAAGVDAEQDVTEGEDEVVWLDFVRSKEPAAIALAASSTDSTAKNNGEDGSQESLMRSCLQFSPSLAILSQRRSMHGGCGDATQSSGASSHETDDVSVEAATITSLSSALSSFSDAVDALTETTTVERFEGCAKYVAASTAEEFQKELEKCGGENDVLFLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KI20</accession>
    <name>A0A836KI20_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha</fullName>
            <ecNumber evidence="4">2.5.1.58</ecNumber>
            <ecNumber evidence="3">2.5.1.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">CAAX farnesyltransferase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">FTase-alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ras proteins prenyltransferase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Type I protein geranyl-geranyltransferase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LSCM4_03641</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.58" evidence="4"/>
    <dbReference type="EC" id="2.5.1.59" evidence="3"/>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061575.1">
        <property type="nucleotide sequence ID" value="XM_067205638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KI20"/>
    <dbReference type="GeneID" id="92359572"/>
    <dbReference type="KEGG" id="loi:92359572"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005953">
        <property type="term" value="C:CAAX-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005965">
        <property type="term" value="C:protein farnesyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004662">
        <property type="term" value="F:CAAX-protein geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004660">
        <property type="term" value="F:protein farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF1">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE_GERANYLGERANYLTRANSFERASE TYPE-1 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG5473572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="753" mass="84644" checksum="B5871B8E73DED4CB" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KI77</accession>
    <name>A0A836KI77_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine aminopeptidase S33 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060767.1">
        <property type="nucleotide sequence ID" value="XM_067205215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KI77"/>
    <dbReference type="GeneID" id="92359149"/>
    <dbReference type="KEGG" id="loi:92359149"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000117">
        <property type="entry name" value="Monoglyceride lipase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051044">
        <property type="entry name" value="MAG_DAG_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11614">
        <property type="entry name" value="PHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="1">
        <location>
            <begin position="56"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5471650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="311" mass="34413" checksum="79B0F38C65674375" modified="2021-09-29" version="1">MPCCCSGGHRLPFATPGRTPPDPKLFPHYMQNAQNLWLHFSEWWPHGDGGVTPAPPTKGVVFIVPGLGEHTGRYDSVALRLNQEGYVVFSMDNQGSGGSEGERLYVERFSHFVDDICVFIEFIQQRYDALRSLPTFLMGHSMGGLISVLVAQRDAGGLRGVVLSGPALGLSKPVSGFMRSLGHFLSAWLPKLPVHKLNPNLVSHNPPVVQLVKQDPFYSNAVLRARFTDEMLEAQDRAAMATPVSAFPFLIVHGEEDELCSLEKSRWFFENAPSKDKHLVSYPGAAHEVLTELCRGVVMAEVINFMNERAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KIB6</accession>
    <name>A0A836KIB6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ubiquitin-ribosomal protein eL40 fusion protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LSCM4_03294</name>
        <name evidence="17" type="ORF">LSCM4_03308</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">LSCM4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the 60S subunit of the ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involved in protein degradation via the proteasome. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Part of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the ubiquitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060858.1">
        <property type="nucleotide sequence ID" value="XM_067205306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KIB6"/>
    <dbReference type="SMR" id="A0A836KIB6"/>
    <dbReference type="GeneID" id="92359240"/>
    <dbReference type="KEGG" id="loi:92359240"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000014">
        <property type="entry name" value="Ubiquitin-60S ribosomal L40 fusion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1060.50:FF:000001">
        <property type="entry name" value="ubiquitin-60S ribosomal protein L40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001975">
        <property type="entry name" value="Ribosomal_eL40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038587">
        <property type="entry name" value="Ribosomal_eL40_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01020">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01377">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="15">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00035124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00035298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG5471741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG5471755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="128" mass="14668" checksum="AD217F7EB465E274" modified="2021-09-29" version="1">MQIFVKTLTGKTIALEVEASDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEEGRTLADYNIQKESTLHLVLRLRGGLMEPTLIALAKKYNWEKKVCRRCYARLPVRATNCRKKACGHCSNLRMKKKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KIC9</accession>
    <name>A0A836KIC9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SNF2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060902.1">
        <property type="nucleotide sequence ID" value="XM_067205350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KIC9"/>
    <dbReference type="GeneID" id="92359284"/>
    <dbReference type="KEGG" id="loi:92359284"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SNF2 N-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5471785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="199" mass="22304" checksum="EB5C8097ECC1C47C" modified="2021-09-29" version="1">MRLILTGTPLQNDLTELWKLIEYAGPQLFSHKDAYQRYLCEAAAAPSSRREFRACEEGEDEGCEDVAGQKSTKRRLAAGVVWAHANQVEAGITAYEGKASLLACLKTALRPFVLRRVKATVGIELPPKHDLVLPTPLTPKQRAYHARVEADGRYSFSRPMHLRKCCIRPFLIDNFCKGYEAFGAPPQAYAARDRPDLML</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KK04</accession>
    <name>A0A836KK04_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tubulin--tyrosine ligase</fullName>
            <ecNumber evidence="11">6.3.2.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LSCM4_04332</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the post-translational addition of a tyrosine to the C-terminal end of detyrosinated alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-tyrosine + ATP = C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-tyrosyl-[tubulin] + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17605"/>
            <dbReference type="Rhea" id="RHEA-COMP:16434"/>
            <dbReference type="Rhea" id="RHEA-COMP:16435"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:149554"/>
            <dbReference type="ChEBI" id="CHEBI:149555"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the tubulin--tyrosine ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.25" evidence="11"/>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062255.1">
        <property type="nucleotide sequence ID" value="XM_067206318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KK04"/>
    <dbReference type="SMR" id="A0A836KK04"/>
    <dbReference type="GeneID" id="92360252"/>
    <dbReference type="KEGG" id="loi:92360252"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004835">
        <property type="term" value="F:tubulin-tyrosine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052492">
        <property type="entry name" value="Tubulin-tyrosine_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46570">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46570:SF1">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0630">Potassium</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="389"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="435"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG5475747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="477" mass="52309" checksum="98D5686054F17731" modified="2021-09-29" version="1">MRPFTTCAAVTPASAVAAAPVSPTAAAASPKMARATAAEPEAAGYFFLGSSTFSVYEEMARQLREEGWRRKTEAAITTADLILGDRFHIPYTLLRSERMALSSRFRGTRWVNYFEGSHRLTLKAAMVQLMKEVDTHWPMWLPESYAIGGDQLKKLDERRALLESLTLAGDDDAVWIVKPSSGAKGRNILLLRAAAVPGWLEELPESGRAMYVVQRYIDRPLLLSHGRKFDIRVWALLVSPYSIYAYSQASCRTASVPYDVTDITNIHAHLTNHCLQVRAEHFGEYEGGNEMWLPQLQAYLTSIGKPPDLLETRVLPAIQELLVRTLLALMPQVAVPATEAYKCFQLFGYDVILTEEAEVRLLEINGSPGVAERFLVPLVRSMRGLLGAGPKDRATPSAAACGADDTCGEERSSRSSSGLASPTNAPNSRPGGRCASRAPSAATSPARITRSWRLEDECFVLLWRRGDAVPPGLVGVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KKS7</accession>
    <name>A0A836KKS7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_05361</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5477966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062873.1">
        <property type="nucleotide sequence ID" value="XM_067207305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KKS7"/>
    <dbReference type="SMR" id="A0A836KKS7"/>
    <dbReference type="GeneID" id="92361239"/>
    <dbReference type="KEGG" id="loi:92361239"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="12"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="195"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="211"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5477966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="227" mass="23764" checksum="F56443BEC15E4FF1" modified="2021-09-29" version="1">MTAAAASWSPDYAVVITGLPAQGISAHDVRQFMTFCGAVKDVRLFPAASTSSSASATRSALVLFESSSSVPYAEVLGGGVFRGKAVFVRRATAAEVETLSVCCDAEPVAVEAAAVPLPPVQASVAAPAHASVVGNGAPVPSNLLQQVSQTISDQRGRFWTQVREGVMKLAHSAATLEIKAAEAVAEARITQVPPSVHGNGPAPQQYYHTPAQPQWGEQPTWQRTPKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KL58</accession>
    <name>A0A836KL58_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_03808</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061741.1">
        <property type="nucleotide sequence ID" value="XM_067205804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KL58"/>
    <dbReference type="SMR" id="A0A836KL58"/>
    <dbReference type="GeneID" id="92359738"/>
    <dbReference type="KEGG" id="loi:92359738"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18316">
        <property type="entry name" value="BTB_POZ_KCTD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000185">
        <property type="entry name" value="Btb/poz domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499:SF136">
        <property type="entry name" value="GH08630P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499">
        <property type="entry name" value="POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="42"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="377"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5474635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="475" mass="49978" checksum="3F4CDB7B1B217F13" modified="2021-09-29" version="1">MPATNCKRPREHSGAPADEAATQDTARCAMEAKDAAATPLDRVVVLNVGGTKITTLHSTLCSSPSLLAQWAENNFQEFPRDLQGYPFLDRDPENFVHILNYLRGYGLPNKADDLVVVAEDAELYQLESLKREIGLDPPSMWRFTPGPGIRDDGVEFSTSDILDLCGTEPLSTGLAHTIVFRVDKCELVSIGVVAFKEIQHDMQIRRQKNTVCYCNTGELVRYWSADALYEQGVLYKSQDEITVRVEFAQPGVPLEPPSSSKTMEQLPPPLQPALALSSAPLPASVAGATSFSSSGVMPSRPLPLVLDASMAMTNASSGAEPPITSPAFQPGSSAMDVAANRPMQQGGSSPTRAPANPTALPPSQSLGVSGGGVPGIATATTPTSGPSAAPASASGVAPASPLLPFAPVVLDPEDPDATVGAIVTFFKGDREVCRARWPAPVPPLQFAVSMQGASAVSILKTTSVSADAVGMENDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KL67</accession>
    <name>A0A836KL67_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061771.1">
        <property type="nucleotide sequence ID" value="XM_067205834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KL67"/>
    <dbReference type="SMR" id="A0A836KL67"/>
    <dbReference type="GeneID" id="92359768"/>
    <dbReference type="KEGG" id="loi:92359768"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21451">
        <property type="entry name" value="DLC-like_TCTEX1D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.40">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005334">
        <property type="entry name" value="Tctex-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038586">
        <property type="entry name" value="Tctex-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255:SF7">
        <property type="entry name" value="DYNEIN LIGHT CHAIN TCTEX-TYPE PROTEIN 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255">
        <property type="entry name" value="T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03645">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5474665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="126" mass="14476" checksum="77069D55FFAECB9C" modified="2021-09-29" version="1">MASEYAAAPRESFTMPRPGTKFSEPAVKRIIKEVCEDMVGPDRPYVYEEAQPLIKDLCAEIQQRTVRLGYERYKLVTHATVTEASSQGMRVASRCLWDPETDNYASYTHSTQYMHVTIVVFGVYWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KLC9</accession>
    <name>A0A836KLC9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GTP-binding nuclear protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_04495</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">LSCM4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the small GTPase superfamily. Ran family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062688.1">
        <property type="nucleotide sequence ID" value="XM_067206479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KLC9"/>
    <dbReference type="SMR" id="A0A836KLC9"/>
    <dbReference type="GeneID" id="92360413"/>
    <dbReference type="KEGG" id="loi:92360413"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00877">
        <property type="entry name" value="Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002002">
        <property type="entry name" value="GTP-binding nuclear protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002041">
        <property type="entry name" value="Ran_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071:SF0">
        <property type="entry name" value="GTP-BINDING NUCLEAR PROTEIN RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071">
        <property type="entry name" value="RAN GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00627">
        <property type="entry name" value="GTPRANTC4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51418">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5477277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="216" mass="24240" checksum="674D20E2ADA3908A" modified="2021-09-29" version="1">MQQTPSDCVASFKLILVGDGGTGKTTFVKRHLTGEFEKRYVATVGVDVHPLTFHTNRGKICFNCWDTAGQEKFGGLRDGYYVEGQCAIIMFDVTSRNTYKNVPNWYRDITRVCDNIPIVLVGNKVDCADRQVKAKMITFHRKKGLQYYDISAKSNYNFEKPFVWLAKKLANDPDLMLVEVPMLDTDVVALTAEQVAALEAEQQAMANAPLPMGDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KLE4</accession>
    <name>A0A836KLE4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Uracil-DNA glycosylase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_02691</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060269.1">
        <property type="nucleotide sequence ID" value="XM_067204717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KLE4"/>
    <dbReference type="GeneID" id="92358651"/>
    <dbReference type="KEGG" id="loi:92358651"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="entry name" value="Uracil-DNA glycosylase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5470003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="32995" checksum="F4F7B1B2CECCDA56" modified="2021-09-29" version="1">MPNVKKASAAPLKRRAVAKTIAAMHRVRGATAAFTSNAAAKSASTAVSKTTPVVDEDHPIGPVVHAECRVLLCGTFPPVKKSIHFYYPNANNDMWKVLGQVFCDDAYAFYTPAACTSSLPSAPSKPLGSRAATRALDEARILRFADSQAVGFFDVCRRVRRHRGNSADDNIEALERTDVVRDVLSHTPHCTGIIATGTLALKMLLDVLTTHGTFRTSGEEPMEAVLMARQGHRKYKLPPIGGKLKWIPSETCAFRSAVWIHRGPSTSRALPLKLEDKTRHYRRAFAEHLPLPLATAPVPVANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KM03</accession>
    <name>A0A836KM03_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RING-CH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LSCM4_04087</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062013.1">
        <property type="nucleotide sequence ID" value="XM_067206076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KM03"/>
    <dbReference type="GeneID" id="92360010"/>
    <dbReference type="KEGG" id="loi:92360010"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16495">
        <property type="entry name" value="RING_CH-C4HC3_MARCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46065">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCH 2/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46065:SF3">
        <property type="entry name" value="FI20425P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033004540" description="RING-CH-type domain-containing protein" evidence="11">
        <location>
            <begin position="23"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="482"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="520"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="551"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="588"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="12">
        <location>
            <begin position="390"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG5475505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="635" mass="70626" checksum="F85B1750AD4B2DDC" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KNW0</accession>
    <name>A0A836KNW0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_02025</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061099.1">
        <property type="nucleotide sequence ID" value="XM_067204062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KNW0"/>
    <dbReference type="SMR" id="A0A836KNW0"/>
    <dbReference type="GeneID" id="92357996"/>
    <dbReference type="KEGG" id="loi:92357996"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:001068">
        <property type="entry name" value="Protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF228">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="26"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="260"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="457"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
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            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="273"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="411"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5481820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="913" mass="93486" checksum="B894E284FEB437A1" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KTU5</accession>
    <name>A0A836KTU5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Pre-mRNA splicing factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_05396</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5477998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062905.1">
        <property type="nucleotide sequence ID" value="XM_067207337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KTU5"/>
    <dbReference type="SMR" id="A0A836KTU5"/>
    <dbReference type="GeneID" id="92361271"/>
    <dbReference type="KEGG" id="loi:92361271"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001369">
        <property type="entry name" value="Putative pre-mRNA splicing factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF91">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE PRP16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="381"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="570"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="80"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="243"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1028"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="331"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1045"/>
            <end position="1060"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5477998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1086" mass="119056" checksum="3C31F274752F0A11" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KV64</accession>
    <name>A0A836KV64_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000007">
        <property type="protein sequence ID" value="KAG5486907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065701.1">
        <property type="nucleotide sequence ID" value="XM_067208296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KV64"/>
    <dbReference type="GeneID" id="92362230"/>
    <dbReference type="KEGG" id="loi:92362230"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5486907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="106" mass="11462" checksum="48D6CC94C4647CB4" modified="2021-09-29" version="1">MGHSAKITRGGNKKRVNQGRLEAKLRAQGAKSHTTTVKESVEAKRLLKQRAQAIAGELKAKAQANGHAPSHQQQEQQPRPANMGTSIVRMAPKPAAKPKPLTQSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KVL5</accession>
    <name>A0A836KVL5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Lipid desaturase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_05760</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fatty acid desaturase CarF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063464.1">
        <property type="nucleotide sequence ID" value="XM_067207691.1"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-UniPathway"/>
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            <end position="69"/>
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            <end position="104"/>
        </location>
    </feature>
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            <begin position="90"/>
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            <dbReference type="ARBA" id="ARBA00007620"/>
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            <dbReference type="ARBA" id="ARBA00022692"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5479753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="279" mass="31135" checksum="38AD6C0A19AC470A" modified="2021-09-29" version="1">MQMSFASSAVMASGGELIGREGDPSVRRANAKKLAAGYTRKKRFLECCYLSASTFLWCSNVVSCGRYFVFSPDANSMQLLWMPLFIIAAMALADLVSGLAHWGLDTWGSPDTPIFGSFIRSFREHHVNQTAMCRHDFIETNADTTLPLLPVLLMQYACVHSTNHGGNGYAANLHVRNIGAHVFLCTFFLFVGITNEIHKWSHQAKQSRVVRKAMDIGIILSPISHRKHHKDPFDRTYCITTGWLNPLLDSVNFWRRLESLVSSVTGAVPRSNDQALLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KVZ7</accession>
    <name>A0A836KVZ7_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_07653</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000012">
        <property type="protein sequence ID" value="KAG5484880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064992.1">
        <property type="nucleotide sequence ID" value="XM_067209532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KVZ7"/>
    <dbReference type="GeneID" id="92363466"/>
    <dbReference type="KEGG" id="loi:92363466"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="66"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="172"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="256"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="526"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="591"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="651"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="687"/>
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        </location>
    </feature>
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        <location>
            <begin position="435"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="77"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
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        <location>
            <begin position="298"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="405"/>
            <end position="415"/>
        </location>
    </feature>
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        <location>
            <begin position="526"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="617"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="662"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5484880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="827" mass="86746" checksum="A3B9217B3FD4E74E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KW66</accession>
    <name>A0A836KW66_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Wd40 repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_06089</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000020">
        <property type="protein sequence ID" value="KAG5480323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067208014.1"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A836KW66"/>
    <dbReference type="GeneID" id="92361948"/>
    <dbReference type="KEGG" id="loi:92361948"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="581"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="554"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="610"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5480323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="806" mass="87198" checksum="62A267FD3B29555A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836L264</accession>
    <name>A0A836L264_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase</fullName>
            <ecNumber evidence="6">4.1.1.130</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Coenzyme Q biosynthesis protein 4 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_06836</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Lyase that catalyzes the C1-decarboxylation of 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid into 2-methoxy-6-(all-trans-polyprenyl)phenol during ubiquinone biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoate + H(+) = a 2-methoxy-6-(all-trans-polyprenyl)phenol + CO2</text>
            <dbReference type="Rhea" id="RHEA:81179"/>
            <dbReference type="Rhea" id="RHEA-COMP:9551"/>
            <dbReference type="Rhea" id="RHEA-COMP:10931"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:62731"/>
            <dbReference type="ChEBI" id="CHEBI:84443"/>
            <dbReference type="EC" id="4.1.1.130"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of a multi-subunit COQ enzyme complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion inner membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the COQ4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.130" evidence="6"/>
    <dbReference type="EMBL" id="JAFHLR010000009">
        <property type="protein sequence ID" value="KAG5486128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065459.1">
        <property type="nucleotide sequence ID" value="XM_067208748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836L264"/>
    <dbReference type="SMR" id="A0A836L264"/>
    <dbReference type="GeneID" id="92362682"/>
    <dbReference type="KEGG" id="loi:92362682"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120539">
        <property type="term" value="F:4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03111">
        <property type="entry name" value="Coq4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007715">
        <property type="entry name" value="Coq4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027540">
        <property type="entry name" value="Coq4_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12922">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12922:SF7">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN COQ4 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05019">
        <property type="entry name" value="Coq4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="1 6" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032370850" description="Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial" evidence="7">
        <location>
            <begin position="26"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5486128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="244" mass="27213" checksum="6451F20C9CC1FB7A" modified="2021-09-29" version="1">MRVRPTMQWVPLIATGAALAHQAGAFAVESLRAIRDPTNGDAVSAVGELSSLDSLENMKNCMMADMRGRNILKHRPVVGDEVLEFSRGLAPSTFGFRYAAYMDRNHFLPSGRTVVRHIADPTLAYVMTRYRQCHDFLHAITGCGRTVEEELALKIFEWKHTGLPLGLLSVVGGAPRLSATQWANMRLYWEWASLNAPSSCHGQPAIPMYLNVPWEDMLAKEYGEVVAYTGIMPLPVFLEKQQTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836L447</accession>
    <name>A0A836L447_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_07564</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000004">
        <property type="protein sequence ID" value="KAG5487883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066080.1">
        <property type="nucleotide sequence ID" value="XM_067209448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836L447"/>
    <dbReference type="GeneID" id="92363382"/>
    <dbReference type="KEGG" id="loi:92363382"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434:SF48">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="5">
        <location>
            <begin position="131"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="310"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="320"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5487883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="355" mass="39883" checksum="F83A7923B3815C1A" modified="2021-09-29" version="1">MSTGAARLSHEAVSYLPMLTRGQRGAMLAVALGAGYMLLRQRLVPKWIVRQWFLLSATALIIPSSVLVYLFDPLRYLGVPRSWVQRIGVFVLGCAFKAVWWVNPQIRMHVRFDANEDGKPACWDDIPRTTIAFTLNHTSFWDPFELIGVTPMSHLMQMRTLMKSSLRKIPIFGGIFDRVGHFPVYFTSDEDGNFHVDKEKQAVVSQHVNAHLRRGGSLVFFPEGMVNRTPETLQPFRFGTFTTIMEHRLPVYYIVAVGGEKTWAPQMPYGGLPADIHIRIGAYPIDFDKESGKSVAVGLQQRMQQVRDEIASEVASAEAAQRRREGPVSESQETKPLRVAPLCTSRKAHAATAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FLL4</accession>
    <name>A0A836FLL4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Macro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_00354</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058538.1">
        <property type="nucleotide sequence ID" value="XM_067202437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836FLL4"/>
    <dbReference type="GeneID" id="92356371"/>
    <dbReference type="KEGG" id="loi:92356371"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5464907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="30854" checksum="122D6C4653B7FF77" modified="2021-09-29" version="1">MVSYLEGQVTRDGRKRAPRHLFGANYRKPFPWIRVGLGLAAMAAVADMVYRRMSYVSPQEQFIRKIKIRPYGVMGTQMTLQGSLRQDGPKPDDTTVITDPCDLMHIFTSAAGAVGTSGAIYKWVGLANAFPNDVVMAMSKVGDAKHHQYGLKGSETGEKHVIHVSAPDFREGIWSEREAAIELSRAYRNVLHEYVVSECSTLRMVPLSDGLQAGPLYNQLPAITHSALLMGFEQLHMFDKECVLRDEKNIELCIFMNREWDMFNNAFANLPVGPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FRH7</accession>
    <name>A0A836FRH7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Mitochondrial chaperone BCS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LSCM4_00901</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059619.1">
        <property type="nucleotide sequence ID" value="XM_067202969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836FRH7"/>
    <dbReference type="SMR" id="A0A836FRH7"/>
    <dbReference type="GeneID" id="92356903"/>
    <dbReference type="KEGG" id="loi:92356903"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
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        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00004">
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    </dbReference>
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        <property type="entry name" value="AAA_lid_BCS1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
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    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="73"/>
            <end position="246"/>
        </location>
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    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="277"/>
            <end position="399"/>
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            <dbReference type="ARBA" id="ARBA00004434"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
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            <dbReference type="ARBA" id="ARBA00022692"/>
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        <source>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
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            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
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            <dbReference type="SMART" id="SM01024"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5467817.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="493" mass="54567" checksum="21EBA259B3CB39C1" modified="2021-09-29" version="1">MFTRSSGNAAEAAPAANAADAHLSQANIGGVSSPQIDLAGLLPEGWDSSNSILARTVGPLLSNPYFSAGAGLWVLTVGGAFGRQASVMFQALMRRKFVVSLEVSNRDSAYEWMLRWLSNQKTFKVQQMSVLTRTASFDYSSSDRMRAECLFGPCPNQRHYFFYEGRPLTLTRRRRDNVSPGYSDDIFETLEFTTIGTSATVLQNIVKEAQKFAEQEDSDHTVVYMNGGNSWTRQSRPRSRRAIESVVLPNGMSEFILGDVKKFLSSSSFYKQLGVPYRRGYLLHGPPGCGKTSFVMALAGELRLSISLLNLSNRNLNDESLTSLLNEARVDTIVLLEDIDRAFSNECNVTMSGLLNALDGVGAQEGRLVFMTTNHVELLDAALIRPGRADVKIEIGLLDVGQSKRMYRKFFPNATEGMVEAFGREFPPYVISAAQLQSHLFFHRDDAVAATTTLPAFIANSRAFDASMEQRRSRKAKLQQSLPRAPLLDFDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FTP7</accession>
    <name>A0A836FTP7_9TRYP</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name evidence="1" type="ORF">LSCM4_02488</name>
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    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
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            <taxon>Discoba</taxon>
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            <taxon>Trypanosomatida</taxon>
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            <taxon>Leishmaniinae</taxon>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067204517.1"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5469092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="120" mass="13510" checksum="98F29DFE271BD669" modified="2021-09-29" version="1">MKQISFRVIDTLCAQLLQEKHDAARVDKLIADGIHQGVVDKDTLPLIIQKTAVTQGEWCLALRVLQSKHLDAHRVRRDDNIWAIVDKGVPDSASSKSAAHRALQAIYRSRLRNKSPPLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FVX9</accession>
    <name>A0A836FVX9_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">LSCM4_03017</name>
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    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
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            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060588.1">
        <property type="nucleotide sequence ID" value="XM_067205036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836FVX9"/>
    <dbReference type="GeneID" id="92358970"/>
    <dbReference type="KEGG" id="loi:92358970"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5470322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="134" mass="13897" checksum="1B53B81141D276C3" modified="2021-09-29" version="1">MNALTVVLSTVVADSEAGVPHVMPVDSTYTQYEMNRQGALSHATVSNPLFSPQLSGAKLRGGSTSACASVDHLQSIPLDGSEDSRGLYVVEDVLDCTEAVKLGGAGVLFLNFGMSEVVTTTRPVAPARATLTDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FYF3</accession>
    <name>A0A836FYF3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sodium stibogluconate resistance protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060744.1">
        <property type="nucleotide sequence ID" value="XM_067205192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836FYF3"/>
    <dbReference type="SMR" id="A0A836FYF3"/>
    <dbReference type="GeneID" id="92359126"/>
    <dbReference type="KEGG" id="loi:92359126"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40744:SF1">
        <property type="entry name" value="SODIUM STIBOGLUCONATE RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40744">
        <property type="entry name" value="SODIUM STIBOGLUCONATE RESISTANCE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5471627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="622" mass="68286" checksum="6A5164C658A50AB2" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FZF4</accession>
    <name>A0A836FZF4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Leucine-rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_00157</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058347.1">
        <property type="nucleotide sequence ID" value="XM_067202246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836FZF4"/>
    <dbReference type="SMR" id="A0A836FZF4"/>
    <dbReference type="GeneID" id="92356180"/>
    <dbReference type="KEGG" id="loi:92356180"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454">
        <property type="entry name" value="NISCHARIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454:SF56">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="334"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5464716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="489" mass="52158" checksum="963DF62EAB30BE5A" modified="2021-09-29" version="1">MTTAMSLCASSLLPSVGDGVAVSTASARSAELHDLTLEELQNSLSDLGYNPYGELVYTRSNLASKHICALPGLQRYVHLQRLCVDDNGLTELDAVRYMPQLVHLHARHNRLSSEVFASLAVAAAGCLEQLYLDGNCITSLDGLEKLPFLLDFKCCSNRVRHLPARCLAAAHRLMHLSLSGNALETIEADAFAAAPLLRVLDLSENLLSSTDFLSSVTPQIENVNISNNRVRHLSAAVEQLSCLTVLDVGRNELAGLKEVRVLRCLKALRTLTFEGNTALECLSHDAPRGGGRQGGLLSPTAHGTEYHQEVVMSDEGEDSESLVSSCGGGGGITAATSTAPVTSGAAAEGDGDPDQSSTLYPSSTTTGELTSNEYGAASNGRPCAHPIPGWKSSGSLAARARMPTTADYVGLAAPETNGFVRSVGSVRRDATLDVRVHYQKEVLALPPREQVYLWTLSVLPQLTEVNGRAIRPEELAKAAFLFRANALKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G0G0</accession>
    <name>A0A836G0G0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flavoprotein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_02075</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061148.1">
        <property type="nucleotide sequence ID" value="XM_067204111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G0G0"/>
    <dbReference type="SMR" id="A0A836G0G0"/>
    <dbReference type="GeneID" id="92358045"/>
    <dbReference type="KEGG" id="loi:92358045"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071513">
        <property type="term" value="C:phosphopantothenoylcysteine decarboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="entry name" value="Flavin prenyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359">
        <property type="entry name" value="HOMO-OLIGOMERIC FLAVIN CONTAINING CYS DECARBOXYLASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359:SF6">
        <property type="entry name" value="PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="Homo-oligomeric flavin-containing Cys decarboxylases, HFCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="4">
        <location>
            <begin position="21"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="298"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5472752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="326" mass="35477" checksum="98FA0234057351C1" modified="2021-09-29" version="1">MASPVPLQTPLPTEEHYPSVHLLLLITGSVAAIKTGLLLDQLSTERCNIRIAATKAAFHFLRRAQPSNTGIPFQSIITDEQEWSEWQAMNDAVVHIELRRWADLVVIAPLNANTLAKVATGLCDNLVSSVMRAWEVKQKPVILCPAMNSAMWMHPITAKQLDQLAEWYCEPDLRGRTKCTDIINATFPLDGSCASPVTAAVCESVEPNAREAEHGATASTNASSSSTAVAASAVAAAALNPRLPATLRESMYQVVGPVSKRLACGDLGIGGMASVEEIALHIRHTMKLIRDEKRRCYEEARERHAAEARSALPAQHPPQEKPRSQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G1W8</accession>
    <name>A0A836G1W8_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_03556</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061490.1">
        <property type="nucleotide sequence ID" value="XM_067205553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G1W8"/>
    <dbReference type="GeneID" id="92359487"/>
    <dbReference type="KEGG" id="loi:92359487"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039963">
        <property type="entry name" value="Unchar_22kDa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38828">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38828:SF2">
        <property type="entry name" value="MEIOSIS-SPECIFIC NUCLEAR STRUCTURAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="79"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="29"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="81"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5473487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="197" mass="23672" checksum="66A4F9DC1C5729C4" modified="2021-09-29" version="1">MATEECRKPATEQRLTPDAEENLVQRLYYRQMKLLAQREEERCATLERARAQMQKHISKEEEHHLVSRIYDQQVERFANSKAERDRRVEEEVHKNDKKMDPSDIDDQVRRMYEEERKKSQARREELNSRYMPTAEPKKIGKKELHASVERLSHVDWEKRDEELFKKYVYPYDPRSTKISRDDEQAMADRLSTTKGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G204</accession>
    <name>A0A836G204_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_00109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058300.1">
        <property type="nucleotide sequence ID" value="XM_067202199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G204"/>
    <dbReference type="GeneID" id="92356133"/>
    <dbReference type="KEGG" id="loi:92356133"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5464669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="579" mass="62725" checksum="1047662A8E942FF9" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G2E6</accession>
    <name>A0A836G2E6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CobW/HypB/UreG nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_00340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058525.1">
        <property type="nucleotide sequence ID" value="XM_067202424.1"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A836G2E6"/>
    <dbReference type="GeneID" id="92356358"/>
    <dbReference type="KEGG" id="loi:92356358"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="CobW-likC_sf"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051316">
        <property type="entry name" value="Zinc-reg_GTPase_activator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748">
        <property type="entry name" value="COBW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748:SF31">
        <property type="entry name" value="ZINC-REGULATED GTPASE METALLOPROTEIN ACTIVATOR 1A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW/HypB/UreG nucleotide-binding" evidence="1">
        <location>
            <begin position="16"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5464894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="355" mass="39214" checksum="81FFA9F1CBF86C70" modified="2021-09-29" version="1">MSSEDECPELISARVPVTVLTGFLGSGKTTLLHYILSSDHKMRIAVIVNEFEFGKTIEKGLTLKSSEKPDDEWLELNNGCMCCTAQTQTVKALESLMQRRGTFDLILVETSGLADPGPIAAMFWQDAPLCGSLYLSGIVTLVDSVNICKYLHDDDVRQEAERQILMADKLVLNKVDIATAAQQEAALAAVREINPVATVIQSDHSRVPNLRDILLIDTTRAATELVHLHDHHHSSITAVSLEFADAEHVLAVSSQRDVYAIGSDLLYRCAEYGFEVVRCKAAIWSYENGQYSLFQLQSIGELFDVTPMIGQSVPLGCTRALVLGKKLDEEKLRSIFAKYLKPTKRVPEEGGEEDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G4J4</accession>
    <name>A0A836G4J4_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059029.1">
        <property type="nucleotide sequence ID" value="XM_067203338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G4J4"/>
    <dbReference type="GeneID" id="92357272"/>
    <dbReference type="KEGG" id="loi:92357272"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5466139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="589" mass="64496" checksum="493B680BCA379A56" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G5M1</accession>
    <name>A0A836G5M1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine-threonine kinase receptor-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_04199</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat STRAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062125.1">
        <property type="nucleotide sequence ID" value="XM_067206188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G5M1"/>
    <dbReference type="SMR" id="A0A836G5M1"/>
    <dbReference type="GeneID" id="92360122"/>
    <dbReference type="KEGG" id="loi:92360122"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032797">
        <property type="term" value="C:SMN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000818">
        <property type="entry name" value="WD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877:SF13">
        <property type="entry name" value="SERINE-THREONINE KINASE RECEPTOR-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
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        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="76"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="277"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5475617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="321" mass="35245" checksum="F998DDA68A22DF20" modified="2021-09-29" version="1">MSKYVAPTGKVAPAAPAADNGVADITKVKICSGHTRPVCHINYSDIIDGTFWFVTSCHDAKPMLRNGQTGDWVGTFEGHKGAVFCSAFNAGATRLVTGSGDYSAMVWDALTGKKLHVWGHPKYIKSCDWMDQRIATGCFDGNIRIYDATRYDAEPLSFGSPDAINVKSTYFLDTNTMVTACENVIMKWDLRDTSGPYLRREIPGLNFVEYTHRHSIVAAHEKSISFIDTTSLEVKNSFTTSEDVECASLSPDGQRVAAGSKLKAKEFTLDGVEVESNRGHHGPVFHIRWASDGNSYASGAEDGMVRVWPSHEIIEKYDTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G6N1</accession>
    <name>A0A836G6N1_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        </location>
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            <end position="82"/>
        </location>
    </feature>
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        <location>
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            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="209" mass="23300" checksum="5F02E828DA6781C9" modified="2021-09-29" version="1">MSGIIHKESLPAQSLIKRRRVDNQATTEPCREGKCEDDNEKRVDNVERSGAGENGTIRCTEAQSGSFGSASNSLAKTENASISSSDSSSDDDDQIERENARLAKLREQRSRRQQEQHKTGKYAVSSSTQSSANVPGSVDGTSPPSVLQAQEGALQVNSYDHDVLFRRAVWRHPPKAATDEEKRKQKWDSVLNRTQDSAAFRHFMKNYFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836G6S1_9TRYP</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067203663.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="92357597"/>
    <dbReference type="KEGG" id="loi:92357597"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        </location>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="557"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5466464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="586" mass="60411" checksum="DFB64DBFBE90C221" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G9F6</accession>
    <name>A0A836G9F6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="1" type="ORF">LSCM4_01020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="protein sequence ID" value="KAG5467934.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067203086.1"/>
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    <dbReference type="GeneID" id="92357020"/>
    <dbReference type="KEGG" id="loi:92357020"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5467934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="190" mass="20632" checksum="761087EDCA302DDF" modified="2021-09-29" version="1">MFHRSCTWLFFNRIFKVSKPPMSGYEIAELPNEKVLHEFMQFYRSKGVVVILHSGASYAASAAASSGGSRSSRASAPVGPSAKTCSTATAASASASKPKTDLLQDPLTRSFISSINAMNLGNPEEVKLALVPGPLAPSFVEEYNVITYPTSLLFLNGQCVYRVVGARTRELSIKSLFMLRNGGRNIFSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836G9L4_9TRYP</name>
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        <recommendedName>
            <fullName evidence="5">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">LSCM4_05289</name>
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    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Leishmania</taxon>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5477897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067207236.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="92361170"/>
    <dbReference type="KEGG" id="loi:92361170"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="320"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
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        <location>
            <begin position="260"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5477897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="439" mass="49944" checksum="8E729878A918B996" modified="2021-09-29" version="1">MRCTRFCLCSSLSRVHDATSVVKDYQKMEAQRKELVERKAKKEYESYPLRYQLLECRPGLPLALMKLKYLLACRRTHPDAGGDAESFLRVSLAYQDVMKDYGVETVDNKIVNLGNFQSDDHEAQNYLEARARICSYIPISTLEEHIRQIEEIQSRLGAELSEKLTSSSDEAMWLLEDIEDVMEQTGLKTVRVRVLENGKVRVDDVKALTDGTEKPLFFANGEAPPEWRNPDSTTVAEAASVNDTSADASTSGAPPKSTIEPPQSTENTLQEAEVCRSDIEVLNAKNTLQERPDVAGLAARTATEVMNNTEEVKQMKLESSVVYVFLISLMMLVYVYIEGTMRVKRQASARPEIMEHVTSDTMLPWWGNDAEYESQVKRIFVDEWRKARAASRRAQTFQDGVARESLDEETKRDMDLKIFTVTAEKLRAMRDNAERHPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GC37</accession>
    <name>A0A836GC37_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_01821</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">LSCM4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000022">
        <property type="protein sequence ID" value="KAG5479232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063325.1">
        <property type="nucleotide sequence ID" value="XM_067203866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GC37"/>
    <dbReference type="SMR" id="A0A836GC37"/>
    <dbReference type="GeneID" id="92357800"/>
    <dbReference type="KEGG" id="loi:92357800"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000969">
        <property type="entry name" value="CAMK family protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF75">
        <property type="entry name" value="AURORA KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="7"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="296"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5479232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="370" mass="40854" checksum="76554446F35F256E" modified="2021-09-29" version="1">MRRVGDYEILDMVGEGAYSKVKRVRHIPTGCMFVAKIVPKTNQQVENEVRLEISILRRLQHNNIVQLIEILESTNNYYIILEPVMGGDLCDIIVGMDRPLPEQDVAALLIQLVAGVRACHCNGVAHRDLKPENLLLGTDGVLKISDFGLSRLHRESNFQASTNEYAHTLTGTLAYVAPEVFGGSYDAFRADIWSMGCIAYVLLTQNFPFGSTTDPHALEARIRSGEVSIMPSSVSAEASNLCMWLLSPQPEDRPTLDAVAQHEFFKRYLPAEYLRMTANRKSPIVHGANMNEFSSQVQEETSSCSPIAPSTKRKHHIRSGSAARVSPSRSAATGAASGSNRSSEGRRDREDLVGHGNHGRSELRGYYGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GCX5</accession>
    <name>A0A836GCX5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">rRNA 2'-O-methyltransferase fibrillarin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Histone-glutamine methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LSCM4_00328</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-glutaminyl-[histone H2A] + S-adenosyl-L-methionine = N(5)-methyl-L-glutaminyl-[histone H2A] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50904"/>
            <dbReference type="Rhea" id="RHEA-COMP:12837"/>
            <dbReference type="Rhea" id="RHEA-COMP:12839"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Fibrillarin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058513.1">
        <property type="nucleotide sequence ID" value="XM_067202412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GCX5"/>
    <dbReference type="SMR" id="A0A836GCX5"/>
    <dbReference type="GeneID" id="92356346"/>
    <dbReference type="KEGG" id="loi:92356346"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990259">
        <property type="term" value="F:histone H2AQ104 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008649">
        <property type="term" value="F:rRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000056">
        <property type="entry name" value="Fibrillarin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000001">
        <property type="entry name" value="Fibrillarin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00351">
        <property type="entry name" value="RNA_methyltransf_FlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000692">
        <property type="entry name" value="Fibrillarin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020813">
        <property type="entry name" value="Fibrillarin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003276">
        <property type="entry name" value="PRK04266.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335:SF17">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335">
        <property type="entry name" value="RRNA 2-O-METHYLTRANSFERASE FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01269">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006540">
        <property type="entry name" value="Nop17p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00052">
        <property type="entry name" value="FIBRILLARIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01206">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00566">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG5464882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="298" mass="31639" checksum="281510AB4100580A" modified="2021-09-29" version="1">MRGGFGRGSGGRGSFGRGGTRGGGRGGARGGSRGGARGGGRGGARGGGRGGRGGGAGTKVIVEPHMLHPGVFISKAKTDSLCTLNMVPGISVYGEKRIELGATQGDDKKEYRLWNPYRSKLASAIYAGVSSIHMGPGSKVLYLGGATGTTVSHVSDLVGPEGMVYAVEFSHRVGRDLVEMSKRRSNIVPIIEDARYPMKYRMLVPMVDCVFMDVAQPDQARILALNTQAFLKNGGHYVISIKANCIDSTLEAPVVIASELNKLKKDKLKPLEQVSLEPFERDHAVVVGVYRPVKKSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GDC3</accession>
    <name>A0A836GDC3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L18a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_02758</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060330.1">
        <property type="nucleotide sequence ID" value="XM_067204778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GDC3"/>
    <dbReference type="SMR" id="A0A836GDC3"/>
    <dbReference type="GeneID" id="92358712"/>
    <dbReference type="KEGG" id="loi:92358712"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.10:FF:000013">
        <property type="entry name" value="60S ribosomal protein L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00273">
        <property type="entry name" value="Ribosomal_eL20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028877">
        <property type="entry name" value="Ribosomal_eL20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023573">
        <property type="entry name" value="Ribosomal_eL20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021138">
        <property type="entry name" value="Ribosomal_eL20_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10052">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01775">
        <property type="entry name" value="Ribosomal_L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002190">
        <property type="entry name" value="Ribosomal_L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160374">
        <property type="entry name" value="RplX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL20" evidence="5">
        <location>
            <begin position="7"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5470064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="179" mass="20745" checksum="47D59A899BAA5AA4" modified="2021-09-29" version="1">MVKPHLRHYQVVGREAPSEKNPEPTVYKFEVFAPNFVVAKSRFWRMMKIKNKVKATHGDVLSCKVVKDAKLVARNYLVDIAYYSQRCGYTRMVKEFRDVSKTGAVSQAYHDLASRHRARYHNIEVLCVKSIPDHEVKRLSIAQYHASNLSFPLLQRRTKAARKDRAIFVKKNTKRAVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GDR7</accession>
    <name>A0A836GDR7_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_02969</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNA polymerase II subunit 5-mediating protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060540.1">
        <property type="nucleotide sequence ID" value="XM_067204988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GDR7"/>
    <dbReference type="SMR" id="A0A836GDR7"/>
    <dbReference type="GeneID" id="92358922"/>
    <dbReference type="KEGG" id="loi:92358922"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019212">
        <property type="term" value="F:phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23159">
        <property type="entry name" value="Prefoldin_URI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000024">
        <property type="entry name" value="Prefoldin_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052255">
        <property type="entry name" value="RNA_pol_II_subunit5-mediator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15111">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT 5-MEDIATING PROTEIN NNX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15111:SF0">
        <property type="entry name" value="UNCONVENTIONAL PREFOLDIN RPB5 INTERACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="148"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="325"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="522"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="155"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="171"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="433"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="560"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5470274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="569" mass="59955" checksum="7A986A825B089043" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GG10</accession>
    <name>A0A836GG10_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_07043</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000018">
        <property type="protein sequence ID" value="KAG5481332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064011.1">
        <property type="nucleotide sequence ID" value="XM_067208948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GG10"/>
    <dbReference type="GeneID" id="92362882"/>
    <dbReference type="KEGG" id="loi:92362882"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5481332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="200" mass="22141" checksum="53C2AF39326EA36B" modified="2021-09-29" version="1">MMRRCMLLRSGHGDLFPTSKAAAHLDPEWVMSRVVPRAPGKGRCYADFTTPEHRGKFQMISPEVHQVKVISIDGPSAAEMHHCATKRPSAASIAATAAGVKRALDAHRCKTNDTPMARANIAAKRAAEELAKTRDFMAHKRVPTQRNPKHVPTVDCPSSQGYIEDRVNKLRKMENTNPNGYVREYMPWGAKPPAPAPPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GGI3</accession>
    <name>A0A836GGI3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_03266</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060831.1">
        <property type="nucleotide sequence ID" value="XM_067205279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GGI3"/>
    <dbReference type="GeneID" id="92359213"/>
    <dbReference type="KEGG" id="loi:92359213"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="409"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        </location>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
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                <person name="Gatherer D."/>
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            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12 13">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059093.1">
        <property type="nucleotide sequence ID" value="XM_067203402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GLU7"/>
    <dbReference type="SMR" id="A0A836GLU7"/>
    <dbReference type="GeneID" id="92357336"/>
    <dbReference type="KEGG" id="loi:92357336"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031647">
        <property type="term" value="P:regulation of protein stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000171">
        <property type="entry name" value="Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024729">
        <property type="entry name" value="USP7_ICP0-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029346">
        <property type="entry name" value="USP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF644">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14533">
        <property type="entry name" value="USP7_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12436">
        <property type="entry name" value="USP7_ICP0_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="144"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5466203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1163" mass="133266" checksum="28A6D883F2B7D900" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GM78</accession>
    <name>A0A836GM78_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycosomal membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_01564</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059303.1">
        <property type="nucleotide sequence ID" value="XM_067203612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GM78"/>
    <dbReference type="GeneID" id="92357546"/>
    <dbReference type="KEGG" id="loi:92357546"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008733">
        <property type="entry name" value="PEX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42266">
        <property type="entry name" value="GIM5B PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42266:SF1">
        <property type="entry name" value="GIM5B PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05648">
        <property type="entry name" value="PEX11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5466413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="24732" checksum="89E9F115D5077EE1" modified="2021-09-29" version="1">MSAAVFQYLGNTGDRDKVMAIVQFLPMALAGPAGNAGCTSLSKSLKSLSNMADGYRAITRLALLFNALSKPTLEALSKPKGDVFLDRVDQLSHFFHVCFCFFENTAVLSSHNVCSSRFGRLGGCAVTCWFYTLLLGLMRQAYVMTQKKNSPEEQKRHTITTVKLGCFLIFSLTCFPKGGPQLLEDVSGPLVPLHKTLQLIAPKHLQLNDSIRGTFGFIASMCDFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GP94</accession>
    <name>A0A836GP94_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein transport protein SEC23</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Protein transport protein sec23</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_06578</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEC23/SEC24 family. SEC23 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000010">
        <property type="protein sequence ID" value="KAG5485622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065206.1">
        <property type="nucleotide sequence ID" value="XM_067208495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GP94"/>
    <dbReference type="SMR" id="A0A836GP94"/>
    <dbReference type="GeneID" id="92362429"/>
    <dbReference type="KEGG" id="loi:92362429"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1670:FF:000019">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000041">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000043">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037364">
        <property type="entry name" value="Sec23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141:SF0">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="8">
        <location>
            <begin position="337"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="8">
        <location>
            <begin position="490"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="10">
        <location>
            <begin position="655"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="9">
        <location>
            <begin position="782"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="48"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5485622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1043" mass="112105" checksum="B665DA79F9578177" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GQ61</accession>
    <name>A0A836GQ61_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_01873</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000022">
        <property type="protein sequence ID" value="KAG5479281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063374.1">
        <property type="nucleotide sequence ID" value="XM_067203915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GQ61"/>
    <dbReference type="SMR" id="A0A836GQ61"/>
    <dbReference type="GeneID" id="92357849"/>
    <dbReference type="KEGG" id="loi:92357849"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01049">
        <property type="entry name" value="RNRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="entry name" value="Ribonucleotide Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033909">
        <property type="entry name" value="RNR_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030475">
        <property type="entry name" value="RNR_small_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409:SF18">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00368">
        <property type="entry name" value="RIBORED_SMALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5479281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="392" mass="44243" checksum="2D4F7CAF5D2E0C87" modified="2021-09-29" version="1">MTGESKVTDAGDAPAKRARTEEADTEIAPPLSEAAVVSSAATADDLVVKPIAAGADVSAVDEATEGTSAEEEPLQRENPFRYVLFPIQYHDIWRKYKEQESCIWTVEEIDLGNDMKDWVALDDGERHFIKHVLAFFAGSDGIVVENLAQRFMNDVKVPEARAFYGFQLMMENIHSETYSVLLDTYITDSEEKLRLLHAIQTIPCIKKKAEWAVRWIGSSASFQERLIGFAAVEGIFFSGSFCALFWLKKRGLMPGLTFSNELISRDEGLHTDFACLLYNSHIRHKLPRERVLEIIVDAVNIEREFICDALPVRLIGMNSELMAQYIEFVADRLLVSLGEEKHYNATQPFDFMEMISLQGKTNFFEKKVGEYQKAGVMSTEGTSKKFSLSEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GQB3</accession>
    <name>A0A836GQB3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_05447</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5478049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062956.1">
        <property type="nucleotide sequence ID" value="XM_067207388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GQB3"/>
    <dbReference type="SMR" id="A0A836GQB3"/>
    <dbReference type="GeneID" id="92361322"/>
    <dbReference type="KEGG" id="loi:92361322"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000001">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="7">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5478049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="166" mass="19200" checksum="4EE3603C94389E70" modified="2021-09-29" version="1">MIKAVLIINTAGKIRLLSFYEKTISLAQQQELVRSIHRAISRRGDELCNFVDNFKEWPTPDTRVIYRRYATLCFVFVTDSSESQLAILDLIQVFVESLDRTFENVCELDLIFHSEKVQYTLMEMIMGGMVLEMSRDEIIRSLGEMNRLSANTFAENTTSRTLSGYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GS58</accession>
    <name>A0A836GS58_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5468963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059940.1">
        <property type="nucleotide sequence ID" value="XM_067204388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GS58"/>
    <dbReference type="SMR" id="A0A836GS58"/>
    <dbReference type="GeneID" id="92358322"/>
    <dbReference type="KEGG" id="loi:92358322"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5468963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="288" mass="31805" checksum="FB8E5E1CD1E9662E" modified="2021-09-29" version="1">MHHLSVFNYVAGELGHDEPVLHAVVATHRYLPPDLPEEDFMATLPHIVTASSCRPSSSGGPAGADVSMVSTAVVAGEDALAAPKEVALTVEQELAKLSEKLAAWKVRRLADLQAPGGIHTGSRLSQMEAEMKQRLARRRMDEQNRAQKRMEVLLTSLGPRIEKQLQLMTREFISGQVPASDSARAAATSNVNDSPSAGKVATAAATTSPPSPRARILCDQEYYVALQKIALEERDARQSLRRHMWIAHHLTHLVADEASFRRCIETREGVWREQLDEESRAYVEADRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GSG4</accession>
    <name>A0A836GSG4_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_02510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060090.1">
        <property type="nucleotide sequence ID" value="XM_067204538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GSG4"/>
    <dbReference type="GeneID" id="92358472"/>
    <dbReference type="KEGG" id="loi:92358472"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="604"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="513"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5469113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="628" mass="65244" checksum="C411689D2B4D5DBA" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GUC4</accession>
    <name>A0A836GUC4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinteoplast poly(A) polymerase complex 1 subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060309.1">
        <property type="nucleotide sequence ID" value="XM_067204757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GUC4"/>
    <dbReference type="SMR" id="A0A836GUC4"/>
    <dbReference type="GeneID" id="92358691"/>
    <dbReference type="KEGG" id="loi:92358691"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="279"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5470043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="839" mass="93687" checksum="21626105AE71FF45" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GY88</accession>
    <name>A0A836GY88_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FCP1 homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_04998</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Probable phosphatase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CTDSPL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062275.1">
        <property type="nucleotide sequence ID" value="XM_067206972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GY88"/>
    <dbReference type="SMR" id="A0A836GY88"/>
    <dbReference type="GeneID" id="92360906"/>
    <dbReference type="KEGG" id="loi:92360906"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000015">
        <property type="entry name" value="CTD small phosphatase-like protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="5">
        <location>
            <begin position="108"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5476042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="290" mass="33002" checksum="E27548C990C2AB58" modified="2021-09-29" version="1">MSAVRQPTTQEAINFFKQYREKFQSSSGDGNFPAQNSVNASPAQNIVTQVHQVGVATGLPNRSIVPMDRRNGTTTTRLDLLRRSPTNCSPCLMREEGMKPLLPPLPFASVPKVTLVLDVDETLVHSTFQPSSDVVYDKVLLVPSEGKKYTVSVKYRPYLEDFLRFVSHRFEVVIFTASMRAYCDKLMDEIDPQGILGNLRLFREHCTLCERSYVKDLHRLGRDLRRVVIVDNSPAAYSFQQRNAIPIKTWISDPKDRELFLLLPLLDSLSMCDSVYSELDLYNARGCEYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GYY4</accession>
    <name>A0A836GYY4_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_00790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG5467711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067202863.1"/>
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    <dbReference type="KEGG" id="loi:92356797"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5467711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="60" mass="6866" checksum="5533EC968FB942FA" modified="2021-09-29" version="1">MRTWGHLIQGYSRFVSASLGAMPMFLWSFKSHRQQQRIFQAKRAAIALTQAQNPSGNPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GZI5</accession>
    <name>A0A836GZI5_9TRYP</name>
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        <recommendedName>
            <fullName evidence="5">Rab geranylgeranyl transferase component A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_07257</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Rab GDI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000015">
        <property type="protein sequence ID" value="KAG5483044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064540.1">
        <property type="nucleotide sequence ID" value="XM_067209157.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="loi:92363091"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Rab geranylgeranyl transferase component A, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
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    </dbReference>
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        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="932"/>
            <end position="956"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5483044.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1041" mass="113310" checksum="CF75565B7212FF39" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H0F5</accession>
    <name>A0A836H0F5_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_04384</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
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            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062578.1">
        <property type="nucleotide sequence ID" value="XM_067206369.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92360303"/>
    <dbReference type="KEGG" id="loi:92360303"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="534"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="739"/>
            <end position="771"/>
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1048"/>
            <end position="1096"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1143"/>
            <end position="1168"/>
        </location>
    </feature>
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        <location>
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            <end position="1370"/>
        </location>
    </feature>
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        <location>
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        <location>
            <begin position="1526"/>
            <end position="1604"/>
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        <location>
            <begin position="6"/>
            <end position="54"/>
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        <location>
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            <end position="194"/>
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            <begin position="534"/>
            <end position="567"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="591"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="605"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
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            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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            <end position="1079"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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            <end position="1224"/>
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            <end position="1331"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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            <end position="1352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
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            <end position="1482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1530"/>
            <end position="1544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1545"/>
            <end position="1555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1583"/>
            <end position="1592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5477167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1604" mass="172997" checksum="84701E8FD033A35C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H1A2</accession>
    <name>A0A836H1A2_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_02379</name>
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    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Kinetoplastea</taxon>
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            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5468986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059963.1">
        <property type="nucleotide sequence ID" value="XM_067204411.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836H1A2"/>
    <dbReference type="GeneID" id="92358345"/>
    <dbReference type="KEGG" id="loi:92358345"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="51"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="128"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="600"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="660"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="730"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1194"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1356"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="570"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="834"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1031"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1265"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="71"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="173"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="205"/>
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        </source>
    </evidence>
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</entry>
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            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
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            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
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    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
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                <person name="Al-Salem W.S."/>
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            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Kwakye-Nuako G."/>
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                <person name="Al-Salem W.S."/>
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            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <reaction evidence="13">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
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            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family. PFA5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="8"/>
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        <property type="project" value="UniProtKB-EC"/>
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    </dbReference>
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        <source>
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        <source>
            <dbReference type="Pfam" id="PF01529"/>
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        <source>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="scientific">Leishmania orientalis</name>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000009">
        <property type="protein sequence ID" value="KAG5486031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067208651.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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        <location>
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    </feature>
    <feature type="coiled-coil region" evidence="1">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="223"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="249"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="751"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="763"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1019"/>
            <end position="1036"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5486031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1036" mass="111461" checksum="2A896D6FD81FCBB2" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H368</accession>
    <name>A0A836H368_9TRYP</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">LSCM4_02711</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060287.1">
        <property type="nucleotide sequence ID" value="XM_067204735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H368"/>
    <dbReference type="GeneID" id="92358669"/>
    <dbReference type="KEGG" id="loi:92358669"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5470021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="260" mass="29396" checksum="11B97AB9975058C6" modified="2021-09-29" version="1">MPANGAKSRRQMLRDGRKLSVEKLVEFVFIKSPRTLSFSHRSMGSLRHPYSRLIFEATAACTTTRSKITYLLEAFLEAKAEKQNWMRAERIFDSMLGDALMEKMKLDLLLSSELLQRFEVLWSRLGGAAGGVVSEDTYKQFQQQLYFTLFEIEDMALLPATMQFILEDYQYDSRGKSVIDFGGFANSMLELADNWTQSRAVADFASFTDRIIECCPDSSAQSSKARAPGDFTLSKEAFFRGGVVVPRVEGGQTVYCRTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H3R6</accession>
    <name>A0A836H3R6_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060587.1">
        <property type="nucleotide sequence ID" value="XM_067205035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H3R6"/>
    <dbReference type="GeneID" id="92358969"/>
    <dbReference type="KEGG" id="loi:92358969"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5470321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="488" mass="53501" checksum="7C0F1EF94647EE22" modified="2021-09-29" version="1">MTVESATGSGSCCDRHSDSTDTPVVPRMGAFHTTANISLDEKMWCLSKPCPAPPAVVALADDLAWKRSIVSAEEARPELPSRLSVLSLEVVAESLVGCSDHVEQQSGAAVTAAEEEEEADDGCIPFDYETEMEECSRYTFSDGPYSLSKSAALAAAAAGSPRMIAASSSCRRPDTPRIPSVLALPHSDDQDLEQVPLSPQWCERQRRDNASHHADEHNAWQQGLKQAATSEPSQMRYALRSLVREACCREIRVLRSLPAISFLRMNAPQLESRTRSWPCASRVAASEASEVSAGQRKACYIQIIREHWRALEERLEELLAETEKESVAVSESRLRSVGYALNALSLFSSDPKLIIREIDMGQVEEQRRQRHDREAQLLTTLESQGRLFLLPTLYAEEVEEPVPVLHIESVLTPSEKIGKYTHPWQVLSPDASLYSPSLSPTSEESIGALSPCSSGCISATCSPMLASQSPSVAPTRMKVGFSDVWKGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H4I4</accession>
    <name>A0A836H4I4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dynein axonemal assembly factor 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LSCM4_02970</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Neuron projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Dynein axonemal particle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060541.1">
        <property type="nucleotide sequence ID" value="XM_067204989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H4I4"/>
    <dbReference type="SMR" id="A0A836H4I4"/>
    <dbReference type="GeneID" id="92358923"/>
    <dbReference type="KEGG" id="loi:92358923"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120293">
        <property type="term" value="C:dynein axonemal particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036159">
        <property type="term" value="P:inner dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036158">
        <property type="term" value="P:outer dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06469">
        <property type="entry name" value="p23_DYX1C1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000106">
        <property type="entry name" value="CS_domain/TPR_repeat/Tetratricopeptide_repeat_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037894">
        <property type="entry name" value="CS_DYX1C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052004">
        <property type="entry name" value="Dynein_assembly_factor_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46492">
        <property type="entry name" value="DYNEIN ASSEMBLY FACTOR 4, AXONEMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46492:SF1">
        <property type="entry name" value="DYNEIN AXONEMAL ASSEMBLY FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="CS" evidence="13">
        <location>
            <begin position="2"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="11">
        <location>
            <begin position="569"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="211"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG5470275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="636" mass="70311" checksum="5CDC843CC594885C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H649</accession>
    <name>A0A836H649_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_03223</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060788.1">
        <property type="nucleotide sequence ID" value="XM_067205236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H649"/>
    <dbReference type="GeneID" id="92359170"/>
    <dbReference type="KEGG" id="loi:92359170"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5471671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="425" mass="46391" checksum="1A7DF067EB82FED1" modified="2021-09-29" version="1">MCCGGCYTCSGLALTPGICALLCPKAFRLRCSSSAAAPLPTLSLFLSFFITFSLSAYRAYISIQQSGTATSSQTRSVPGDSSAGKRHSMLGSLDAATGDALRSFQNALDRAQQLLQRDDERFKATAQLLRDLTIEVDCLKADSAPHSITRQRREALQAEKLKMLHHTRHQREAIAETAAHIQHLQEPRVRLSEQVDALKGDVKALRRQYGLRAAQVHAFIAQFLQPQNNLENLRFQLAQLQQGRVAQAESVKAAKRLLEERKTDLAALQAAGRVDATVCPNVGVTACNRHSSPVKGGNNGSAVSTLATGSDEEQRSDESEECAATTLLTEAERRAEAARRRSEQVAAHKAAEMQQGAEEARLEALRANLRRQVLLLCQEIEEVDAAQQREQKAYHDALNDAASGSGAGLHQQCQRCTRDLFDGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H6I3</accession>
    <name>A0A836H6I3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small GTP-binding protein Rab11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_06637</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000010">
        <property type="protein sequence ID" value="KAG5485679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065263.1">
        <property type="nucleotide sequence ID" value="XM_067208552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H6I3"/>
    <dbReference type="SMR" id="A0A836H6I3"/>
    <dbReference type="GeneID" id="92362486"/>
    <dbReference type="KEGG" id="loi:92362486"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002140">
        <property type="entry name" value="Small GTP-binding protein Rab11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="179"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5485679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="209" mass="23371" checksum="3C05805FFB48B5C3" modified="2021-09-29" version="1">MEDTNLSFKIVLIGDSGVGKSNLMTRYTTNEFCQDTPSTIGVEFMTKSVKIEGRDAKIQIWDTAGQERFRAISRSIYHGAKGAMLVYDITNQTSFDSIPTWLQELRVFVPVTCCIFLIGNKCDLEHLRVVKKEVADRFARENGLSFLETSALEKTNVDKAFEWLAKSVFEVVVTPQTRDTERAAPKQGRTVNMNPGESPEAKKKSGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H6L0</accession>
    <name>A0A836H6L0_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_06682</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000010">
        <property type="protein sequence ID" value="KAG5485724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065308.1">
        <property type="nucleotide sequence ID" value="XM_067208597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H6L0"/>
    <dbReference type="SMR" id="A0A836H6L0"/>
    <dbReference type="GeneID" id="92362531"/>
    <dbReference type="KEGG" id="loi:92362531"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015045">
        <property type="entry name" value="MPT-1-like_LmxM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37036">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37036:SF2">
        <property type="entry name" value="DUF1861 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08950">
        <property type="entry name" value="DUF1861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5485724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="316" mass="35449" checksum="53E562DDF9797BA0" modified="2021-09-29" version="1">MNTIQVVREAKKAFEANKRVYESALLTFKGVDGYDVYNCSVPFLYRGKKHIYGRVEKREIWAGSHVRLFEETGKDEFTAVPNGMTWFLEDPFVCKVKGEAFFGGTRVRKVSGHLLSYYCDFFRGGIEQGLYFATGPDNMKDIRCVELADGRIGVFSRPMTDVYTCIGFTIIDDLSELTQKVVSEAEALNVLHPGAWGGVNQAYLLTSGKIGCIAHYSYNSKDEKGRPTSVYLNYSFVLDPETKQAEMERIIGTRSCYPDYPIKAEKLIDCAFSSGIVMREDGRCDLYSGLGDTCEGRITIDYPFDGCGAIVDQLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H746</accession>
    <name>A0A836H746_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000009">
        <property type="protein sequence ID" value="KAG5486024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065355.1">
        <property type="nucleotide sequence ID" value="XM_067208644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H746"/>
    <dbReference type="SMR" id="A0A836H746"/>
    <dbReference type="GeneID" id="92362578"/>
    <dbReference type="KEGG" id="loi:92362578"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5486024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="461" mass="49004" checksum="5A598B8834F3E93B" modified="2021-09-29" version="1">MPATYALARECQLLRSDVEGVLSLAARLLLHTTATASSANGAASASMSSSMSAASFVGPVVGAILTDAHARSLLLNTLVRVLVPARRQKALLDDNKYVRAANMVALQQQQSSNGPRPANAAHEGSNVSQRYRVGRVVGVVPKPGVKAPEAGHGGSAPATVAGFAAAAAEEGQRWLLAVYIGECVEPFAVSAIAEDVFTEAEHRIFVESALSTNREDGSRRASVLPSQQSALLSSETAATVQQSIKDIRLALQLMQAAGKTAATAAVEAATAQLMQRASGVKRSHAASDDDDGKNCKRCTEAAPAREDSGGLGTFFGNGASSQAVRMARLTEDVAARGAQLQQLRQLLQQKEQDLKAALQQQQQQEARHRGEVDVWRAKVEEQSRTHERAAKESRESLEQRDRLLEEANTKLRRLAGMATKYKQIVDAVAALLQRNGSGEESGGRPMTPDDILSALKAKMSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H7U4</accession>
    <name>A0A836H7U4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AP-3 complex subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_07342</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">LSCM4</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Adaptor protein complex 3 (AP-3) is a heterotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000008">
        <property type="protein sequence ID" value="KAG5486414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065480.1">
        <property type="nucleotide sequence ID" value="XM_067209237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H7U4"/>
    <dbReference type="SMR" id="A0A836H7U4"/>
    <dbReference type="GeneID" id="92363171"/>
    <dbReference type="KEGG" id="loi:92363171"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030123">
        <property type="term" value="C:AP-3 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017105">
        <property type="entry name" value="AP3_complex_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22781:SF12">
        <property type="entry name" value="AP-3 COMPLEX SUBUNIT DELTA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22781">
        <property type="entry name" value="DELTA ADAPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037092">
        <property type="entry name" value="AP3_complex_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="9">
        <location>
            <begin position="27"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="760"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="769"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5486414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1134" mass="124240" checksum="55CDC824B53BF179" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H9G9</accession>
    <name>A0A836H9G9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="5">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_02149</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="5"/>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061221.1">
        <property type="nucleotide sequence ID" value="XM_067204184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H9G9"/>
    <dbReference type="GeneID" id="92358118"/>
    <dbReference type="KEGG" id="loi:92358118"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF108">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="192"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="487"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="550"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="785"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5472825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1056" mass="113786" checksum="C75328C2DA44798A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H9S9</accession>
    <name>A0A836H9S9_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_02301</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061371.1">
        <property type="nucleotide sequence ID" value="XM_067204334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H9S9"/>
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    <dbReference type="GeneID" id="92358268"/>
    <dbReference type="KEGG" id="loi:92358268"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT DOMAIN 39B"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5472975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="585" mass="67296" checksum="817F1A6A4B9AAA65" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HA70</accession>
    <name>A0A836HA70_9TRYP</name>
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        <recommendedName>
            <fullName evidence="2">REH2 DRSM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_05660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000016">
        <property type="protein sequence ID" value="KAG5482402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064408.1">
        <property type="nucleotide sequence ID" value="XM_067207594.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="92361528"/>
    <dbReference type="KEGG" id="loi:92361528"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058737">
        <property type="entry name" value="DSRM_REH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42260:SF2">
        <property type="entry name" value="DRBM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42260">
        <property type="entry name" value="DRBM DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26536">
        <property type="entry name" value="DSRM_REH2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="223"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="REH2 DRSM" evidence="2">
        <location>
            <begin position="577"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="REH2 DRSM" evidence="2">
        <location>
            <begin position="780"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="949"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1174"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="382"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="432"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="990"/>
            <end position="1000"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5482402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1235" mass="132422" checksum="78159FB3602A2FD9" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HE54</accession>
    <name>A0A836HE54_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_05724</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_067063429.1">
        <property type="nucleotide sequence ID" value="XM_067207656.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836HE54"/>
    <dbReference type="GeneID" id="92361590"/>
    <dbReference type="KEGG" id="loi:92361590"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Putative serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584:SF369">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="598"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="1394"/>
            <end position="1651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="187"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1177"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1271"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="223"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1275"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="1423"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5479718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1653" mass="180494" checksum="2918851AC2928164" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HEG8</accession>
    <name>A0A836HEG8_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062524.1">
        <property type="nucleotide sequence ID" value="XM_067207221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HEG8"/>
    <dbReference type="GeneID" id="92361155"/>
    <dbReference type="KEGG" id="loi:92361155"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5476291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="277" mass="30115" checksum="607B28D4F4AD96BF" modified="2021-09-29" version="1">MASTLEAEISFLLSVAAHLGHSSEHAGDDEDDTGAAPPVPSLTTSEREVLAELLLLEKKEDDYAFATLSGTAAAGEVEALLAESPLTAMYRGEVDSPYTRFILSFYSSTLYAQAPTRVNTLAIRLFQRFLCGCRGDALQRLHHGCGASSMEVVLRECLNLASNLSSTLQIAAPSKVTSLVIAELNYDAQEVSPLDYLDVLLPHISYLSQMCQQASLLLLAHEEMVRQPSSIVALFTIVFTIRNMGTGDDAVALLLASWPEGRRAAFYRMNAFLNCFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HES6</accession>
    <name>A0A836HES6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cysteine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cysteinyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_07619</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="2"/>
    <dbReference type="EMBL" id="JAFHLR010000012">
        <property type="protein sequence ID" value="KAG5484847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064959.1">
        <property type="nucleotide sequence ID" value="XM_067209499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HES6"/>
    <dbReference type="SMR" id="A0A836HES6"/>
    <dbReference type="GeneID" id="92363433"/>
    <dbReference type="KEGG" id="loi:92363433"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1910">
        <property type="entry name" value="Cysteine-tRNA ligase, C-terminal anti-codon recognition domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890:SF3">
        <property type="entry name" value="CYSTEINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="CYSTEINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA synthetases class I catalytic" evidence="11">
        <location>
            <begin position="53"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5484847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="784" mass="88664" checksum="CB9F82E998674138" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HFZ9</accession>
    <name>A0A836HFZ9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Poly(A)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_04348</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">LSCM4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the polyadenylate-binding protein type-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062542.1">
        <property type="nucleotide sequence ID" value="XM_067206333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HFZ9"/>
    <dbReference type="SMR" id="A0A836HFZ9"/>
    <dbReference type="GeneID" id="92360267"/>
    <dbReference type="KEGG" id="loi:92360267"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000651">
        <property type="entry name" value="Poly(A) binding protein cytoplasmic 1 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1900.10:FF:000006">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.10">
        <property type="entry name" value="c-terminal domain of poly(a) binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036053">
        <property type="entry name" value="PABP-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002004">
        <property type="entry name" value="PABP_HYD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00658">
        <property type="entry name" value="MLLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00517">
        <property type="entry name" value="PolyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63570">
        <property type="entry name" value="PABC (PABP) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51309">
        <property type="entry name" value="PABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="8"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="99"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="188"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="289"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="PABC" evidence="10">
        <location>
            <begin position="467"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5477131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="545" mass="60874" checksum="E35FC0D233744BCA" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HKC5</accession>
    <name>A0A836HKC5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_07495</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000004">
        <property type="protein sequence ID" value="KAG5487817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066014.1">
        <property type="nucleotide sequence ID" value="XM_067209382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HKC5"/>
    <dbReference type="GeneID" id="92363316"/>
    <dbReference type="KEGG" id="loi:92363316"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033046994" description="C-type lectin domain-containing protein" evidence="3">
        <location>
            <begin position="36"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="243"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5487817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="291" mass="31287" checksum="6953D69E1AE7FE63" modified="2021-09-29" version="1">MDAPPSLLRRFAITSTRPFLAILLLLCTATSPTFAFVYTATPTDAQLPAAYAVMNPGTPLQGLYDACNQQNPGTSDRMLMTVRGNVTEMLENAAKGGVLYLGGYYDPASDTWKWWDGRFGGYVFALGPAGKLVASQRPGWAAGYPELNADGSVGNLRYVAFDGSRRGWTNVAGKAVLSGVACESRDDIVPEQKSFPWWAILIIVLAVVVVVIAIVFCFCCSKKKPYDDKEKRQLASRSASFVSRRTSFAPSATSSFSTSRTSSSSHTNSGGTSGTESFDTDRSSSVDSSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HKN1</accession>
    <name>A0A836HKN1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA primase large subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LSCM4_08206</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eukaryotic-type primase large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000003">
        <property type="protein sequence ID" value="KAG5487982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066109.1">
        <property type="nucleotide sequence ID" value="XM_067210076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HKN1"/>
    <dbReference type="SMR" id="A0A836HKN1"/>
    <dbReference type="GeneID" id="92364010"/>
    <dbReference type="KEGG" id="loi:92364010"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07322">
        <property type="entry name" value="PriL_PriS_Eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058560">
        <property type="entry name" value="DNA_primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016558">
        <property type="entry name" value="DNA_primase_lsu_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007238">
        <property type="entry name" value="DNA_primase_lsu_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537:SF3">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04104">
        <property type="entry name" value="DNA_primase_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26466">
        <property type="entry name" value="DNA_primase_lrg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009449">
        <property type="entry name" value="DNA_primase_large_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0639">Primosome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA primase large subunit C-terminal" evidence="12">
        <location>
            <begin position="341"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="541"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="432"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="502"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR009449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR009449-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG5487982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="567" mass="63097" checksum="A5EE7218F2CB4109" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HL45</accession>
    <name>A0A836HL45_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Histone H2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LSCM4_06828</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the histone H2B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000009">
        <property type="protein sequence ID" value="KAG5486120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065451.1">
        <property type="nucleotide sequence ID" value="XM_067208740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HL45"/>
    <dbReference type="SMR" id="A0A836HL45"/>
    <dbReference type="GeneID" id="92362674"/>
    <dbReference type="KEGG" id="loi:92362674"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000043">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055333">
        <property type="entry name" value="HISTONE_H2B_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00357">
        <property type="entry name" value="HISTONE_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="12">
        <location>
            <begin position="12"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG5486120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="111" mass="12417" checksum="69FB154940005615" modified="2021-09-29" version="1">MATPCRPSRKARTTHKSHHKPKRSWNVYVSRSLKAINSHMSMSGRTMKIVNSFVNDIFERIATEAATIVRCNKKRTLGAREVQTAVRLVLPAELAKHAMAEGTKAVSNSCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HLZ6</accession>
    <name>A0A836HLZ6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial import inner membrane translocase subunit TIM50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_04953</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TIM50 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000014">
        <property type="protein sequence ID" value="KAG5483798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064737.1">
        <property type="nucleotide sequence ID" value="XM_067206928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HLZ6"/>
    <dbReference type="GeneID" id="92360862"/>
    <dbReference type="KEGG" id="loi:92360862"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="1" id="KW-0811">Translocation</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FCP1 homology" evidence="3">
        <location>
            <begin position="1"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="107"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5483798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="274" mass="29778" checksum="C3D1D75EB61D24A8" modified="2021-09-29" version="1">MPALKPLLVFGLRGTLVERIHVRSVPEGMPAADLTVGLVKVWLRPHLMEVLSELQPHCRLAIWSSTTARNTHPLVSAVFGSNMLLQASAGAATAGFAGSAAAAAPSSKQEEQGAAGTSATAAVPASSGRGGRFGKKKRPAKDDAAAEETSSAVAIDTPQPQRIHFEFIWSREHTRVDDFRRLNAAVADDNHATVKDLSQVFTQFPSIAGPQNTVLIDDTPSKAKMHADNYVWLDGCNNLRIRDETGLYRLRDFVMRELVPAEDVRTLLPRRIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HMG2</accession>
    <name>A0A836HMG2_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_01900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000022">
        <property type="protein sequence ID" value="KAG5479308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063401.1">
        <property type="nucleotide sequence ID" value="XM_067203942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HMG2"/>
    <dbReference type="GeneID" id="92357876"/>
    <dbReference type="KEGG" id="loi:92357876"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5479308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="330" mass="35302" checksum="8C6A0F98257D6BEF" modified="2021-09-29" version="1">MTDHALLTGTVSNAFEQPASARVEAGEVTSARSYYHLTRSYSMPGIAGSKVLPEPLPSEARRTMQRAIECLSRPPRLLAEQALADAAESLQVPVPVRPSGTPLMLPLFSLEEGTHRHVTAGAHSSLRAVTLNDSALVSELAVSERKAKPVLRPPARNARAWPEAEMIASSFRANHACVEQLPGSGRGVLPARRLQNRHVSKSRMPPKPKGADSSATLWSEAALEADVLAFFGSQDAAMSLTANLSLRADHKAPVSKDSSLTVVDTAQSSLCGLSTSDCIFSAEATVTDKSSVSGVLRSQVIDPQAVLSFHRDGARRQREVPKAVSDARFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HN01</accession>
    <name>A0A836HN01_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial processing peptidase alpha subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_07919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000013">
        <property type="protein sequence ID" value="KAG5484353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064846.1">
        <property type="nucleotide sequence ID" value="XM_067209796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HN01"/>
    <dbReference type="SMR" id="A0A836HN01"/>
    <dbReference type="GeneID" id="92363730"/>
    <dbReference type="KEGG" id="loi:92363730"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000060">
        <property type="entry name" value="Putative mitochondrial processing peptidase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF227">
        <property type="entry name" value="PROCESSING PEPTIDASE ALPHA SUBUNIT, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5484353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="527" mass="58129" checksum="DBB11B2DE2E0DEB9" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HNY3</accession>
    <name>A0A836HNY3_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_07635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000012">
        <property type="protein sequence ID" value="KAG5484863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064975.1">
        <property type="nucleotide sequence ID" value="XM_067209515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HNY3"/>
    <dbReference type="GeneID" id="92363449"/>
    <dbReference type="KEGG" id="loi:92363449"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033004034" evidence="2">
        <location>
            <begin position="17"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5484863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="495" mass="51196" checksum="98CBDC4A5D7F2A7F" modified="2021-09-29" version="1">MFAALSWLLDLDQGHAASSSSTSSTNSCSDSSDSVAGPEEAQPATCTAFARAGGGLMAELHIASATAAAALSGSASEAAASPPGAVYFSPRRLEESFADLEARKATLFATSPCRESPEDGGLVLKSRVGRGGTPAWSASPSPPKIVPLWSLRSYANDAVSFSPIPSPAPAPETATVATSPSASHEDERLLLVSEGVILSASLSSPSSGARFAPVERVEIAKNGSSSSTTDARAAMPTRLTRILDWDKEVHSRRQASPPPGLGASQGEHAARDSTLAHERGGQIADVELEEARFVQRAMKAAWMASRPSHTPLREPRASAVARVDPSNPFLDTAIGGCDGAVPGYSIEYMQPPPRAWGAVRLAGAWGDGVTATPSGAHDSMEDALRRRSTELLPDSAPATAHRNSNARGGDDRPHPLPPTSASAGATLTEFSFAEGMRGTPAEGDADVVHLANGLVTVVLMDADDPHPQAGQSSPPLTHPLAMQVVTAPPWAAQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HQJ7</accession>
    <name>A0A836HQJ7_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_05622</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000016">
        <property type="protein sequence ID" value="KAG5482366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064372.1">
        <property type="nucleotide sequence ID" value="XM_067207558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HQJ7"/>
    <dbReference type="GeneID" id="92361492"/>
    <dbReference type="KEGG" id="loi:92361492"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5482366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="220" mass="23494" checksum="7BE32549149D8495" modified="2021-09-29" version="1">MPAISTPFVMDLRPGEELKLAQAPSAALSTSSSMASADSANVFAKNKFRAMVSEIAFVEEEDASDSGPAAMPEPHNRHRVIRVALLAHLQPQAQGFSTEHLMKTVTLASYNFSNPSPNDAASNRVLPARRGKTGELATSLPSTVTRVEGTVQFRSPLLFHSSGNIQSLSVVAEDMATTPGTSGSSGSVKLYQGARRFGVRLHGVQQTFLTSEQVLLLAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HRS2</accession>
    <name>A0A836HRS2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Plasma membrane ATPase</fullName>
            <ecNumber evidence="15">7.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">LSCM4_07150</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>ATP + H2O + H(+)(in) = ADP + phosphate + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:20852"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Cell membrane</location>
            <topology evidence="15">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.1" evidence="15"/>
    <dbReference type="EMBL" id="JAFHLR010000018">
        <property type="protein sequence ID" value="KAG5481438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064117.1">
        <property type="nucleotide sequence ID" value="XM_067209054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HRS2"/>
    <dbReference type="SMR" id="A0A836HRS2"/>
    <dbReference type="GeneID" id="92362988"/>
    <dbReference type="KEGG" id="loi:92362988"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008553">
        <property type="term" value="F:P-type proton-exporting transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02076">
        <property type="entry name" value="P-type_ATPase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000042">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000005">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000008">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006534">
        <property type="entry name" value="P-type_ATPase_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01647">
        <property type="entry name" value="ATPase-IIIA_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="12 15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="663"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="697"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="734"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="814"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="17">
        <location>
            <begin position="46"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="911"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="926"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="947"/>
            <end position="960"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008804"/>
        </source>
    </evidence>
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        <source>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG5481438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="975" mass="107279" checksum="01DA0720D4D53F7E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HTS0</accession>
    <name>A0A836HTS0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nop domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_05703</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000016">
        <property type="protein sequence ID" value="KAG5482443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064449.1">
        <property type="nucleotide sequence ID" value="XM_067207635.1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000674143">
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    </dbReference>
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        <property type="term" value="C:precatalytic spliceosome"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Putative snoRNA binding domain containing protein"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="Prp31"/>
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        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13904:SF0">
        <property type="entry name" value="U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
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        </location>
    </feature>
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            <dbReference type="PROSITE" id="PS51358"/>
        </source>
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            <dbReference type="EMBL" id="KAG5482443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="239" mass="26191" checksum="AB7E3A4A91AD3497" modified="2021-09-29" version="1">MTTPNLDALLGAPLAAELVSRAGGLWALCKLSDAALRMLGTEEFQSIASSSRAKQLHAGLLLKASLFTDAFGDEEEVDTTDLKAAQKGAAQLGRKCVLIAKADLAGAYPDGSLGEAEKEKLKAAFARLLAEGKVTAEDTQALAVPFVYVRGEAVKHKRGGVKERKKREAQQEPLSVVARATQRVRMGISEEEQVRQLLQREDIRSEFAKERDQQLLKESRKRGREATRDEYDDLQNISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HUX0</accession>
    <name>A0A836HUX0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Threonyl/alanyl tRNA synthetase SAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_07239</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000015">
        <property type="protein sequence ID" value="KAG5483028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064524.1">
        <property type="nucleotide sequence ID" value="XM_067209141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HUX0"/>
    <dbReference type="SMR" id="A0A836HUX0"/>
    <dbReference type="GeneID" id="92363075"/>
    <dbReference type="KEGG" id="loi:92363075"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002196">
        <property type="term" value="F:Ser-tRNA(Ala) deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000019">
        <property type="entry name" value="tRNA synthetases class II (A)/Threonyl and Alanyl tRNA synthetase second additional domain containing protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051335">
        <property type="entry name" value="Alanyl-tRNA_Editing_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43462">
        <property type="entry name" value="ALANYL-TRNA EDITING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43462:SF1">
        <property type="entry name" value="ALANYL-TRNA EDITING PROTEIN AARSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5483028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="496" mass="54143" checksum="44690EBEC9828D6F" modified="2021-09-29" version="1">MATAFMRVGELACQKDSFLRELTATVVSCEPAKRAAAAAKVKVKGASDDVVGEAVAYDVILSDSVLFPEGGGQPCDYGTLRVVSGGDGKADPACGLTAAPPLSITNVRRVGDMCVLTSPAALPVGATVHQIVDWPRRLDHMQHHTGQHLLTAVVERKDTLHLPTVSWSLTHPYCFIQVDVDPYVSDPASPYHAYITKEKKISDDMVAKIEALCNDAIARSTAVECDVFENREVYQQEQDRQRQAAAASPDGAEEAFRSRGIPEDITGPVRIISLDAIDSCTCCGTHLHTLAELQAMYLLHQEVKGTMVKLYFITGERAAQQFHAMYQRERLLVPELGGSRPHDFVSVVQRRSKDALHLEKLIKRWTLELANVEAQRIAAAVSSSHTAHVAVPLRRDDVELEFFNEVRARLDAAGLRRVVLVSAWTAERCVAGTLTSAKDVAGQVFITGGESPADMEKAVQLTKETLEGMKGGISKYGFRGKGSLKEWDTLVARLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HV85</accession>
    <name>A0A836HV85_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Poly(A) export protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_08330</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </evidence>
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    <sequence length="57" mass="6416" checksum="6BFA88FC85DA2742" modified="2021-09-29" version="1">MVAFRRVQSATDASCVRRATFEDEEGERAQGGEEYDFGQERATVLMLQLIAFITVCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
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                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466431.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067203630.1"/>
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        <source>
            <dbReference type="EMBL" id="KAG5466431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
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    </evidence>
    <sequence length="147" mass="17586" checksum="5D2E6EE2C242F59A" modified="2021-09-29" version="1">MSQLWVKRAKAEMTRHSRVLETINRVFPMPFEERRSRVGMTGYATYRWLRYFPVILVPVVVVGTLLETRDYPQEHVFTSLHLWLADHGVFRHDTVKALNPAFEDERRSIEWKANDRKWRFTGTDMPSEREIRQFAAINVDRQSWHSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KCV0</accession>
    <name>A0A836KCV0_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">LSCM4_03216</name>
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            <taxon>Trypanosomatida</taxon>
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            <taxon>Leishmania</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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        <property type="component" value="Chromosome 31"/>
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    </evidence>
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</entry>
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    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
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            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
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            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060063.1">
        <property type="nucleotide sequence ID" value="XM_067204511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KCV5"/>
    <dbReference type="SMR" id="A0A836KCV5"/>
    <dbReference type="GeneID" id="92358445"/>
    <dbReference type="KEGG" id="loi:92358445"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097014">
        <property type="term" value="C:ciliary plasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000002">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF389">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="26"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5469086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="196" mass="21166" checksum="E9F67ED4BC42DD7F" modified="2021-09-29" version="1">MLGRTFLCAQRKIPFYPVNSKNPLVFFDISIGSQPAGRVEMELFKDIVPKTAENFRALCTGEKGVGRSGKPLCFKGSRFHRVIPQFMCQGGDFTAGNGTGGESIYGHKFPDESFAGRAGKHFGPGTLSMANAGPNTNGSQFFICTAATEWLDGKHVVFGQVTKGYDVITKVETQGSQSGATRQPITITDCGEIKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KD34</accession>
    <name>A0A836KD34_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_01079</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059794.1">
        <property type="nucleotide sequence ID" value="XM_067203144.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92357078"/>
    <dbReference type="KEGG" id="loi:92357078"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5467992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1948" mass="216676" checksum="D3E90E07841B7771" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KDY6</accession>
    <name>A0A836KDY6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="11">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LSCM4_03026</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NAD(+) = N(6)-[(R)-lipoyl]-L-lysyl-[protein] + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="9 11">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="11">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="11"/>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060597.1">
        <property type="nucleotide sequence ID" value="XM_067205045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KDY6"/>
    <dbReference type="SMR" id="A0A836KDY6"/>
    <dbReference type="GeneID" id="92358979"/>
    <dbReference type="KEGG" id="loi:92358979"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000001">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000001">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050151">
        <property type="entry name" value="Class-I_Pyr_Nuc-Dis_Oxidored"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912:SF151">
        <property type="entry name" value="DIHYDROLIPOYL DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912">
        <property type="entry name" value="DISULFIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 9 11" id="KW-0274">FAD</keyword>
    <keyword evidence="2 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9 11" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 11" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="13">
        <location>
            <begin position="12"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="12">
        <location>
            <begin position="357"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="455"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="153"/>
            <end position="155"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="190"/>
            <end position="197"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="329"/>
            <end position="332"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="10">
        <location>
            <begin position="50"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG5470331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="476" mass="50605" checksum="344FFC7C155CE842" modified="2021-09-29" version="1">MLRRNIAHLASYDVTVIGGGPGGYVAAIKAAQLGLKTACIEKRGALGGTCLNVGCIPSKALLHATHLYHDAHTNFSKYGLRGGEKVTMDVAAMQAQKTKAVKALTGGVEYLLKKNRVDYYKGEGSFATSSSIKVKGLDGKEETLETRKTIVATGSEPAELPFLPFDEKVVMSSTGALDLDHVPKKMLVIGGGVIGLELGSVWARLGAEVTVVEFAPRCAATTDPDVSKALTDALVKHEKMNIMTNTKVVSGKKSSNGVTIEVEGRDGKRQVLEADALLCSVGRRPHTSGLNAEAINLKMERGFICINDHFETSVPNVYAIGDVVNKGPMLAHKAEEEGVACAEMLAGKPGHVNYSVIPGVIYTNPEVAQVGETEEEVKKKGIDYKVGKFPFNANSRAKAVGTEDGFVKVVTDKKTDRILGVQIVCTAAGEMIAEMALAMEYGASSEDVGRTCHAHPTMSEAVKEACMACFAQTINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KE51</accession>
    <name>A0A836KE51_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromosomal passenger protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061350.1">
        <property type="nucleotide sequence ID" value="XM_067204313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KE51"/>
    <dbReference type="GeneID" id="92358247"/>
    <dbReference type="KEGG" id="loi:92358247"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5472954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="26846" checksum="96CA3A0364967317" modified="2021-09-29" version="1">MEAVAWTPDVVEDLLFRQFIKDEDISRLLPPTPQVSSENFLEKYDQATKILFSYVRNGPVSALASQNVNTASGGKYGGATPVKGFVGRTPAAKPAPPESSRSFARTATPAPAPSNRAPSVQKGNISSPQAAKTKRQRVEWPADVPTNQLLKSNSRSKVAHLTAKRVAAQQSVDPDLIFTQNCGDLPLNVIFAPYPKALKSVSAVRNASGDWRTDTFTAEEEASYKNDLGYVHCGPSQCAYGKWLPSQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KE53</accession>
    <name>A0A836KE53_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal recognition particle receptor subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_02590</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SRP receptor beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060169.1">
        <property type="nucleotide sequence ID" value="XM_067204617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KE53"/>
    <dbReference type="SMR" id="A0A836KE53"/>
    <dbReference type="GeneID" id="92358551"/>
    <dbReference type="KEGG" id="loi:92358551"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019009">
        <property type="entry name" value="SRP_receptor_beta_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09439">
        <property type="entry name" value="SRPRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5469192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="493" mass="52306" checksum="00452D6994EE83AA" modified="2021-09-29" version="1">MMSVLDEVLVNETIIEAVRVALDQFTAEGHPLTAASNEAGMSAEQESVIRSALQAGFQNFWEAARKHVASAASLEHGKETGSNDHSHRVSTIASSAPRTLSAALEQLARNATATQDVVHQAMLSIWAHLRNGANCRGDGVDLIAATAVYAATPEVTRALEAAVSAQRLAAADAVMPANVASKVTAGGTLGHLSSFLAERWVWPLVTLVLGYLLVSFVFGRILGFGGSLGRRRPRSSTVLIGLPDSGKTALYVQLVHHQQLLESRTSMRANVGYMCAAAQHGLSKGTAGVRVIDCPGHPRLYEEMLRAVGEAVNVVVVIDSVTVQDSQHEGVGALAELLFNVLQAPEFYGVRRLLFACTKRDEVISYTSKAVRKLLEAAMVASIESRQNVIGRVESVRDSNNTVITSDGKYGGGRRGGGRRYLLSLDGTDNHDGDGEAALVHGQGRGASGASAKSFSFDQLGIPLAFVDVSSRPNLAEHKYSVTAAEDFLLGNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KEL2</accession>
    <name>A0A836KEL2_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_03452</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061392.1">
        <property type="nucleotide sequence ID" value="XM_067205455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KEL2"/>
    <dbReference type="SMR" id="A0A836KEL2"/>
    <dbReference type="GeneID" id="92359389"/>
    <dbReference type="KEGG" id="loi:92359389"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097014">
        <property type="term" value="C:ciliary plasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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    </dbReference>
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        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="WD40_rpt"/>
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    <dbReference type="PANTHER" id="PTHR12442:SF26">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5473389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="535" mass="58560" checksum="A8751E5D3B4ECEF9" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KFQ6</accession>
    <name>A0A836KFQ6_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060077.1">
        <property type="nucleotide sequence ID" value="XM_067204525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KFQ6"/>
    <dbReference type="GeneID" id="92358459"/>
    <dbReference type="KEGG" id="loi:92358459"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5469100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="361" mass="39478" checksum="58CFCCDF2DC2711F" modified="2021-09-29" version="1">MMRRKPTSPQQKEVRACAKRKPKLQKTTAAVKEKVLKAPAIELRLCGMAPVREAADTRDAVSAVWCASAAKHGWEPQRTKAHRQKCEAGMSFDRYDLAGTANINELVLRHGTMKTSDLKTTRHPVLYERVKKPLNRLSSPFMLDRYLSNLVRALVHPLHNYLQCHHSLHNADEVQVMLMPKDGPIALADRATVPSRPPPPPGACSALRRCYVATNNETLTQESLQAAVADWGVAGVFQIAEFVLVTGEKGCHAEQKLLVHLQTQVLSHAAPPVLPTADQKALIVGERLPCVACRLFAIAFESVAVLLPSHGHLYLSTIPAAGDETDAPAKDSQTSRVTALLASPAVAAERLLSPGRQRVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KGF1</accession>
    <name>A0A836KGF1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_00043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058234.1">
        <property type="nucleotide sequence ID" value="XM_067202133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KGF1"/>
    <dbReference type="SMR" id="A0A836KGF1"/>
    <dbReference type="GeneID" id="92356067"/>
    <dbReference type="KEGG" id="loi:92356067"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5464603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="617" mass="69185" checksum="6F0DF0DE69E0E224" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KGT9</accession>
    <name>A0A836KGT9_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_00505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058684.1">
        <property type="nucleotide sequence ID" value="XM_067202583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KGT9"/>
    <dbReference type="GeneID" id="92356517"/>
    <dbReference type="KEGG" id="loi:92356517"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="864"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="870"/>
            <end position="882"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5465053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1018" mass="109352" checksum="4EA2013A4865ECB7" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KHT2</accession>
    <name>A0A836KHT2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_01228</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067203287.1"/>
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    <dbReference type="GeneID" id="92357221"/>
    <dbReference type="KEGG" id="loi:92357221"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:calcium ion binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:protein serine/threonine kinase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="EF-hand-dom_pair"/>
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    </dbReference>
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        <property type="entry name" value="Protein_kinase_ATP_BS"/>
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    <dbReference type="InterPro" id="IPR008271">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895">
        <property type="entry name" value="CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895:SF92">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="Pkinase"/>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
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        <property type="entry name" value="EF_HAND_2"/>
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    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
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    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ST"/>
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    </dbReference>
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    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
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    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
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        <location>
            <begin position="32"/>
            <end position="772"/>
        </location>
    </feature>
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        <location>
            <begin position="912"/>
            <end position="947"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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            <begin position="1084"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1394"/>
            <end position="1426"/>
        </location>
    </feature>
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        <location>
            <begin position="1548"/>
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        </location>
    </feature>
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        <location>
            <begin position="1637"/>
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        </location>
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        <location>
            <begin position="303"/>
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        </location>
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        </location>
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            <position position="61"/>
        </location>
        <ligand>
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            <dbReference type="PROSITE" id="PS50011"/>
        </source>
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            <dbReference type="PROSITE" id="PS50222"/>
        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1769" mass="188434" checksum="A660AC389358995B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KI52</accession>
    <name>A0A836KI52_9TRYP</name>
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        <recommendedName>
            <fullName evidence="6">FYVE-type domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="7" type="ORF">LSCM4_01629</name>
    </gene>
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        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG5466478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067203677.1"/>
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    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FYVE-type_Zinc_Finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39490">
        <property type="entry name" value="ARRESTIN DOMAIN-CONTAINING PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39490:SF8">
        <property type="entry name" value="ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN 21"/>
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    </dbReference>
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        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FYVE/PHD zinc finger"/>
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    </dbReference>
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        <property type="entry name" value="ZF_FYVE"/>
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    </dbReference>
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    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
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            <end position="374"/>
        </location>
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    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5466478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="374" mass="43065" checksum="AB17F974C7BABAA0" modified="2021-09-29" version="1">MSSSLSSPPPQAAFTPLPHGTIRFEDLGEPVQRLLRSLKGDVSEEDMALLEYVSVKDMAKIYSEMATDRHAEEIWQELRSALQARKEKLARREAELAEKQRALEAEQEAERQRLLQQLEEEERERVAAEEARHQRREERRRRKAEKAAAAAAAEEEAAEQAAAAAEEAAEEAAAAAEEAERQRKAEKKRKRREARARELQEEQAALAAERARHEAKKQQKSLNQQKDWSEYVLSHPLEYAQPNPVEGGQLPTVIEQKELQHTLNAPPVVSEKLLSRTYTPSCEVCGCRFDRPPREWYCPVCNRRNGRNVRVWQPDDDTNNCMMCKEPIGRWSRHHCRNCGRLVCANCSEKRAIIEDLGYDTPVRVCYDCFRQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KIN2</accession>
    <name>A0A836KIN2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor eIF-4E</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_04238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062164.1">
        <property type="nucleotide sequence ID" value="XM_067206227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KIN2"/>
    <dbReference type="SMR" id="A0A836KIN2"/>
    <dbReference type="GeneID" id="92360161"/>
    <dbReference type="KEGG" id="loi:92360161"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.760.10:FF:000022">
        <property type="entry name" value="Putative eukaryotic translation initiation factor eIF-4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF73">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 4E, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5475656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="23787" checksum="C58E1DBC804CEC01" modified="2021-09-29" version="1">MTAPSSISPQKMTNLHKLQRAWTLWYDSPSTYNTENWEMSLVPIMTVHSVEEFFVMLRYMKPLHALRTSSQYHFFQDGVKPMWEDPANKKGGKLWVNLDITNANGRSSNNSSGTAAADSNAAEVKTDLDKAWENVLMATVGEYLDSVEKKDASSEPFVTGIVMSKRKYHNRLAVWVSDAAATDKIEALKKTLTREAALAPIASIVFTKHGEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KIP1</accession>
    <name>A0A836KIP1_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_04270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062194.1">
        <property type="nucleotide sequence ID" value="XM_067206257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KIP1"/>
    <dbReference type="SMR" id="A0A836KIP1"/>
    <dbReference type="GeneID" id="92360191"/>
    <dbReference type="KEGG" id="loi:92360191"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5475686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="140" mass="15937" checksum="33331BDFD103C6CB" modified="2021-09-29" version="1">MAEQITNENLQILLTKLMTDRYCSQEASDLDACIQNFVPQRIDGSHVDQSLQRRGIRRCKPYQEVARKCLEDDKKQTAIFRAAAMAPTCKSEQRALQRCQRAKGRDCEAEALETVYCGMVYLVQRQKERQGGAAAPRPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KJ08</accession>
    <name>A0A836KJ08_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_03825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061758.1">
        <property type="nucleotide sequence ID" value="XM_067205821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KJ08"/>
    <dbReference type="GeneID" id="92359755"/>
    <dbReference type="KEGG" id="loi:92359755"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39290">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39290:SF6">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5474652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="532" mass="59757" checksum="AA01BA8BCC4CAC4D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KKH3</accession>
    <name>A0A836KKH3_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059990.1">
        <property type="nucleotide sequence ID" value="XM_067204438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KKH3"/>
    <dbReference type="GeneID" id="92358372"/>
    <dbReference type="KEGG" id="loi:92358372"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="523"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5469013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="549" mass="58781" checksum="50C63A0C809ED2B3" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KPD2</accession>
    <name>A0A836KPD2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_06958</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Ungrouped subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000017">
        <property type="protein sequence ID" value="KAG5481881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064241.1">
        <property type="nucleotide sequence ID" value="XM_067208867.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836KPD2"/>
    <dbReference type="GeneID" id="92362801"/>
    <dbReference type="KEGG" id="loi:92362801"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00106">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.380:FF:000023">
        <property type="entry name" value="Kinesin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000123">
        <property type="entry name" value="Putative kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.380">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022682">
        <property type="entry name" value="Calpain_domain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022683">
        <property type="entry name" value="Calpain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036213">
        <property type="entry name" value="Calpain_III_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF15">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01067">
        <property type="entry name" value="Calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00720">
        <property type="entry name" value="calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49758">
        <property type="entry name" value="Calpain large subunit, middle domain (domain III)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="10">
        <location>
            <begin position="8"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1178"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1250"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="359"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1221"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1178"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1254"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1281"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="93"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5481881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1434" mass="158180" checksum="331D147DD0C14F7D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KPN5</accession>
    <name>A0A836KPN5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CYTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_06445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000019">
        <property type="protein sequence ID" value="KAG5480877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063878.1">
        <property type="nucleotide sequence ID" value="XM_067208366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KPN5"/>
    <dbReference type="GeneID" id="92362300"/>
    <dbReference type="KEGG" id="loi:92362300"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.320.10">
        <property type="entry name" value="Hypothetical Protein Pfu-838710-001"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34948">
        <property type="entry name" value="OS08G0299200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34948:SF2">
        <property type="entry name" value="TRIPHOSPHATE TUNNEL METALLOENZYME 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="CYTH-like phosphatases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5480877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="742" mass="81470" checksum="D76ACE569E8F16F4" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KPU4</accession>
    <name>A0A836KPU4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_05632</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Consists of at least two heavy chains and a number of intermediate and light chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the dynein light chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000016">
        <property type="protein sequence ID" value="KAG5482376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064382.1">
        <property type="nucleotide sequence ID" value="XM_067207568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KPU4"/>
    <dbReference type="SMR" id="A0A836KPU4"/>
    <dbReference type="GeneID" id="92361502"/>
    <dbReference type="KEGG" id="loi:92361502"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21453">
        <property type="entry name" value="DLC-like_DNAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.740.10:FF:000002">
        <property type="entry name" value="Dynein light chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886:SF2">
        <property type="entry name" value="DYNEIN AXONEMAL LIGHT CHAIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 11" id="KW-0243">Dynein</keyword>
    <keyword evidence="4 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00057688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5482376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="112" mass="13125" checksum="24CEEC351BD61AC3" modified="2021-09-29" version="1">MDTKVKEPEGPCSLEYVRRYTQSLNYPLEKTSDMSEEMRVDCKEIVVNALEKHEDSYELAAKYVKEQMDKKFGPSWHCVIGEGFGFEITYEVKHLMYMFHRGFIAIVVFKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KQK7</accession>
    <name>A0A836KQK7_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_06976</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000017">
        <property type="protein sequence ID" value="KAG5481897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064257.1">
        <property type="nucleotide sequence ID" value="XM_067208883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KQK7"/>
    <dbReference type="GeneID" id="92362817"/>
    <dbReference type="KEGG" id="loi:92362817"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5481897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="317" mass="36400" checksum="88DE2D4F37DF81F2" modified="2021-09-29" version="1">MLCLPALRSRANAAVTACASVKVLSVSSRQYRIIPHLYNEIEELAETQRHGRWSISHRNCLQQPLKKAEIMSDKLNLREGRRSGVLPEKSIARRLSHKYAVDGKVCESKSKTKLINITVVNFDGHPFHFRTYPMPDVTLNTLIDGSGMCHGHATHWGKCNNPDCSDWNHGDGCMVNVDIETLDRLLPPNRWEYTSLTAWRATDRPDITFNTRFSCQIPITEELDGALFALKQLWTRSLRESVSDWGLVDDQATIHSARSKKIEPWAPIIEEPTKVDFPITWDMLWATGYQDIMKEKYSNFRRKDGFHTKPEMWAAYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KQV3</accession>
    <name>A0A836KQV3_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_04025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067206017.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="loi:92359951"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5474848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="221" mass="23608" checksum="1027396CC6547C23" modified="2021-09-29" version="1">MHDEQLRCFRRYTRVFPATAYARHTPRVGCSVATDARSAPHASPSSAASRTSSVKILALLCSKAPPHAFTANTMSKKRSAQSPVVPRKRPHDESVDDGGASAPSRTYTAPSESPRAADGKREGSDANGLCAPAQSSDPSMTAASSAAVDNEAEASTTFASASERSDLTAAPYDRAEPEPTASLYVRVQYDKALITTLPIEVMRVQHPQVLIDYLLSMSVWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KQW3</accession>
    <name>A0A836KQW3_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_04057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061984.1">
        <property type="nucleotide sequence ID" value="XM_067206047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KQW3"/>
    <dbReference type="GeneID" id="92359981"/>
    <dbReference type="KEGG" id="loi:92359981"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="367"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5474878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="386" mass="42336" checksum="59EBCF462CAA8B67" modified="2021-09-29" version="1">MYLAANSTIPAQAPQLEAVQGASTVGGLVPLVEQMYTQQYTEARQQYKASHSRFTARVKRPPPSGLEEYCTRAFHELSFYTSAATAGESCAPSACTHGPRRIGIHSLNHELCLLAQERLRAARVVPKCGAADVVELLVTQEAAEYADLLELEAASFMGVARTYYEQIFGPADNLVWLETQTRRSLEDEYSRATITFLAQLREELWLAQQRLFLRTLGMCPDALPHVAQLRLMAAESYALQQAKLSVLESREAVPLWNHVCAIRGETESEEDITFRRLLLACVVEAHGISGGYLRRDTATGRLRLTYKRIPAFMQDAIAYTVQFEVFAVVLEEEAQRMRIAEEVEDAFASLSAAVASVAKTEGGASSSIATAAPAAPSDVDQPATGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KRA8</accession>
    <name>A0A836KRA8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_05863</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Trypanosomatida</taxon>
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            <taxon>Leishmania</taxon>
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    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063566.1">
        <property type="nucleotide sequence ID" value="XM_067207793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KRA8"/>
    <dbReference type="SMR" id="A0A836KRA8"/>
    <dbReference type="GeneID" id="92361727"/>
    <dbReference type="KEGG" id="loi:92361727"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16448">
        <property type="entry name" value="RING-H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969:SF69">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969">
        <property type="entry name" value="RING ZINC FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="249"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="166"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="196"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5479855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="279" mass="28625" checksum="C797211604B414FE" modified="2021-09-29" version="1">MLPSEPSSPTAGSGDNTEAATSPQMHVHTVVINLGNADGTTTSGNAGMADLFSTVPATVTAVMTAAMDLSDLPGLADLLGDTTPATTAAREWSARSCPPFAPEEVISTFDVVDPPPPSSLVTVAPIPDRGGAEGADNAFSPSSPPAPEVKECAICLEPLFRASSVRAAPESGESVPKSVPRLSELSASDGDAPVVATQSAPSRSPTASSPLCAPRADAAAAACDATPSLAYSVKAESAKDAKTVREVYCGHRFHESCILRWIMLGHYSCPLCRSPFVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KTC5</accession>
    <name>A0A836KTC5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">VTT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_07685</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TMEM41 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000012">
        <property type="protein sequence ID" value="KAG5484912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065024.1">
        <property type="nucleotide sequence ID" value="XM_067209564.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="92363498"/>
    <dbReference type="KEGG" id="loi:92363498"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045014">
        <property type="entry name" value="TM41A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43220:SF18">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 41B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="7">
        <location>
            <begin position="132"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5484912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="328" mass="35412" checksum="D336C729D214A33B" modified="2021-09-29" version="1">MSTVALSPSRSSLCTSLALFVNSSEASVACARVLLAVAVMMHIGNQTERPARHALRVLVPLLSCIVFLLYVTDTFSVFSRVQEIVQAEETSLRSASGISEFCRELQKLAQQQYWQVLLFITLLYLTLQTFCIPGTVVLNAAVGAVMGTLLGVPYCTFLGTMGALCCFLLSRIVGRSLVEAADARLMRGRGLTMIRAQVSHYRADLFVYLIFLRLTPILPNWLVNLASPVIGVPLHTFAGATMLGIVPQTYLAVRFGSLAHDGTPGETRRIVTPWDTLLLAVMGVGILVGFRLKRRFSQERKDGGGGVAAERAFGTAASGGAVCVRPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KTJ3</accession>
    <name>A0A836KTJ3_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_07372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000008">
        <property type="protein sequence ID" value="KAG5486441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065507.1">
        <property type="nucleotide sequence ID" value="XM_067209264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KTJ3"/>
    <dbReference type="GeneID" id="92363198"/>
    <dbReference type="KEGG" id="loi:92363198"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5486441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="578" mass="60280" checksum="2EFA1839116F46E9" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KTY2</accession>
    <name>A0A836KTY2_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_06359</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000007">
        <property type="protein sequence ID" value="KAG5486891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065685.1">
        <property type="nucleotide sequence ID" value="XM_067208280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KTY2"/>
    <dbReference type="SMR" id="A0A836KTY2"/>
    <dbReference type="GeneID" id="92362214"/>
    <dbReference type="KEGG" id="loi:92362214"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF31">
        <property type="entry name" value="CENTROSOME-ASSOCIATED PROTEIN CEP250 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="163"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="435"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="804"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="868"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="922"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="990"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="269"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="163"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="435"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="456"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="475"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="822"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="840"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="868"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1020"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1034"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1090"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1105"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1137"/>
            <end position="1148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5486891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1148" mass="127229" checksum="E06D850C3171CA2C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KV05</accession>
    <name>A0A836KV05_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_08271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000003">
        <property type="protein sequence ID" value="KAG5488046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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            <end position="42"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="133"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="310"/>
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            <begin position="420"/>
            <end position="439"/>
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            <end position="1059"/>
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        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="85"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="999"/>
            <end position="1012"/>
        </location>
    </feature>
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            <begin position="1027"/>
            <end position="1039"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5488046.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
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    </evidence>
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</entry>
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        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
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                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">LSCM4</strain>
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    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KVK1</accession>
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            <fullName evidence="3">t-SNARE coiled-coil homology domain-containing protein</fullName>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067207706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KVM0"/>
    <dbReference type="GeneID" id="92361640"/>
    <dbReference type="KEGG" id="loi:92361640"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5479768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="389" mass="40859" checksum="F83E1D39A9A72068" modified="2021-09-29" version="1">MTSPVSFSASSVAAYTASDHDEGTYMSTVVVQPPSSTCKAVAAAAEAAPPPSHANSSYVNQIGSQCYLLPSSAHGSGVASDAPPALVSAPRIGGSRHGGTRQSPVSLAPLPSPTPPSVWESEETGVAAPEEIGPDIFEDIGAEEDEAAKRDEAKTERCGANRDTQRLYMHPIAAAAAAGASFGFTPPADPITAALARQQQQQYRGEPRSPLSPRTLQALCAASTEGRYPIFLAQLTADDVLAPPPLALTWYPSVHTGVTKFADRKRTADGLTVTAMHQHEKSKMVEEEYDTTEMTSTGAAPPLRRLRTEEFDIPGVGLHPPTPSSSAPASLRTCMLPLGAPSEGCATKLDDSAAAAGTSAASCVNASVPRKRDRDERVYEYLSHGRRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836L4I9</accession>
    <name>A0A836L4I9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Band 7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_08305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000001">
        <property type="protein sequence ID" value="KAG5488228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066275.1">
        <property type="nucleotide sequence ID" value="XM_067210174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836L4I9"/>
    <dbReference type="GeneID" id="92364108"/>
    <dbReference type="KEGG" id="loi:92364108"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5488228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="238" mass="25651" checksum="DA31A69E4B68E7F5" modified="2021-09-29" version="1">MPPASPAPVLAAPSTKERPSSSGGVLLPLAVAGAGLLCLWKVVQVCSVPVHPRCVTVVYDTRRKTVLCTSADREMHRDSLPRVSHFDASLYFGSTLMYWSQTRLLVPPSSFFGVFTLPRGVFEEPGESVNCAVEEVAVRDGSINMAVTIFYTIPFDQIERYLAAVGPEPPNEVIGKAAAHLARVRCAEQSAGILLSKARREAVFLVPYKDHLTSKLMSEAAVLVSDVAVESVVLLEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FLE4</accession>
    <name>A0A836FLE4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein-tyrosine-phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_00228</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058418.1">
        <property type="nucleotide sequence ID" value="XM_067202317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836FLE4"/>
    <dbReference type="SMR" id="A0A836FLE4"/>
    <dbReference type="GeneID" id="92356251"/>
    <dbReference type="KEGG" id="loi:92356251"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF449">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="2">
        <location>
            <begin position="103"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="3">
        <location>
            <begin position="396"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="380"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5464787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="522" mass="56892" checksum="34B178FAAE45ADAD" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FLG1</accession>
    <name>A0A836FLG1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_00258</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058448.1">
        <property type="nucleotide sequence ID" value="XM_067202347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836FLG1"/>
    <dbReference type="GeneID" id="92356281"/>
    <dbReference type="KEGG" id="loi:92356281"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050403">
        <property type="entry name" value="Myosin_RLC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23049">
        <property type="entry name" value="MYOSIN REGULATORY LIGHT CHAIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="6"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="71"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="78"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5464817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="258" mass="27481" checksum="34BA6ED796E5A90A" modified="2021-09-29" version="1">MASVAFLREDIKEVFSIFDEDGSGVISMQDVGRALYTITGHRVARSELLKLVAFAQNAVAKVQQAQQNQQDQVASQQRSKVTSAGSQCSQPGVTTADGEATSASGNTHLSSQAGESISISSVRVASPITQDAAAASAASPSAAAARSQNRFVSSHSHLLDSSEGIDLDVFEQIILRKLKHRSYEEELAYTFALLEDKSYIGFITKESVRRAAAETGESVTEAEIAEMFDPLVTGVSTAAVDLSTFTDVQLKARKAEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FNY7</accession>
    <name>A0A836FNY7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_01433</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059177.1">
        <property type="nucleotide sequence ID" value="XM_067203486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836FNY7"/>
    <dbReference type="GeneID" id="92357420"/>
    <dbReference type="KEGG" id="loi:92357420"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042862">
        <property type="entry name" value="RNF32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14991">
        <property type="entry name" value="RING FINGER PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14991:SF0">
        <property type="entry name" value="RING FINGER PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="161"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="446"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="446"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5466287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="558" mass="59732" checksum="FA8BA790AC418EC3" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FVE8</accession>
    <name>A0A836FVE8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein phosphatase methylesterase 1</fullName>
            <shortName evidence="5">PME-1</shortName>
            <ecNumber evidence="5">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_02761</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Demethylates proteins that have been reversibly carboxymethylated.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>[phosphatase 2A protein]-C-terminal L-leucine methyl ester + H2O = [phosphatase 2A protein]-C-terminal L-leucine + methanol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48548"/>
            <dbReference type="Rhea" id="RHEA-COMP:12134"/>
            <dbReference type="Rhea" id="RHEA-COMP:12135"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:90516"/>
            <dbReference type="ChEBI" id="CHEBI:90517"/>
            <dbReference type="EC" id="3.1.1.89"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060333.1">
        <property type="nucleotide sequence ID" value="XM_067204781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836FVE8"/>
    <dbReference type="SMR" id="A0A836FVE8"/>
    <dbReference type="GeneID" id="92358715"/>
    <dbReference type="KEGG" id="loi:92358715"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051723">
        <property type="term" value="F:protein methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000545">
        <property type="entry name" value="Protein phosphatase methylesterase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016812">
        <property type="entry name" value="PPase_methylesterase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14189:SF0">
        <property type="entry name" value="PROTEIN PHOSPHATASE METHYLESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14189">
        <property type="entry name" value="PROTEIN PHOSPHATASE METHYLESTERASE-1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF022950">
        <property type="entry name" value="PPase_methylesterase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="7">
        <location>
            <begin position="51"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR022950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR022950-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5470067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="352" mass="39060" checksum="E9214BBDC88DAD74" modified="2021-09-29" version="1">MSTMSTSPPLPAPEEHVFINARGERFQCTTFAPSSSCRPPTWSQDTPTPLLLCVHGAGMSGDCFVRMARELQRSFDKSDDTVTNAEGYGEDVDMNIMTYDQRCHGRSTFVGGEDHLAIEVLMRDFLDVLQYAKTQLYPTGNVYVLGHSLGGAVVARALSENKSALERVSGVLLVDIVEGTAQLSLQHMKAFLTNRPETFPEVKDAEVWFLRMGGMQNPQGAEVSVPPLLLQNDETGLWQWRTNIRKMESVWGGWFTGLDEAFISLPCAKMLCTANAERLDKALTVAQMQGKFQFEVIGNGCGHYVMDDATLTIVAKVRRFVKRNEALGQKLKLMNKHLSSQQRNTTASPNCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FVH6</accession>
    <name>A0A836FVH6_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060378.1">
        <property type="nucleotide sequence ID" value="XM_067204826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836FVH6"/>
    <dbReference type="SMR" id="A0A836FVH6"/>
    <dbReference type="GeneID" id="92358760"/>
    <dbReference type="KEGG" id="loi:92358760"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5470112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="524" mass="59322" checksum="62A7C27A6AA4A4F8" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FVN1</accession>
    <name>A0A836FVN1_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060453.1">
        <property type="nucleotide sequence ID" value="XM_067204901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836FVN1"/>
    <dbReference type="GeneID" id="92358835"/>
    <dbReference type="KEGG" id="loi:92358835"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5470187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="117" mass="12873" checksum="A58E888C75DEC275" modified="2021-09-29" version="1">MPHSSNRSMLHRARWLQTASRVADRRTGRILASQMAARLVARSRLPLRLQIATQFPGPHLRRPRPTLLSIANPSSFPSTTAKKMTSGIPTSSASIPRPSSSCPLLYVCVSASLDHKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G318</accession>
    <name>A0A836G318_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_00724</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058900.1">
        <property type="nucleotide sequence ID" value="XM_067202799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G318"/>
    <dbReference type="SMR" id="A0A836G318"/>
    <dbReference type="GeneID" id="92356733"/>
    <dbReference type="KEGG" id="loi:92356733"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000113">
        <property type="entry name" value="Beta-adaptin-like protein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="8">
        <location>
            <begin position="33"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="609"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="651"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="724"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="609"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="654"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="677"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5465269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="746" mass="82434" checksum="798A95B9975C8A94" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G634</accession>
    <name>A0A836G634_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">serine C-palmitoyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_01211</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-serine + hexadecanoyl-CoA + H(+) = 3-oxosphinganine + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:14761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:58299"/>
            <dbReference type="EC" id="2.3.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.50" evidence="3"/>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058964.1">
        <property type="nucleotide sequence ID" value="XM_067203273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G634"/>
    <dbReference type="SMR" id="A0A836G634"/>
    <dbReference type="GeneID" id="92357207"/>
    <dbReference type="KEGG" id="loi:92357207"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017059">
        <property type="term" value="C:serine palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004758">
        <property type="term" value="F:serine C-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000167">
        <property type="entry name" value="Putative serine palmitoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF3">
        <property type="entry name" value="LD36009P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein intermediate chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060350.1">
        <property type="nucleotide sequence ID" value="XM_067204798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GB55"/>
    <dbReference type="SMR" id="A0A836GB55"/>
    <dbReference type="GeneID" id="92358732"/>
    <dbReference type="KEGG" id="loi:92358732"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036157">
        <property type="term" value="C:outer dynein arm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036158">
        <property type="term" value="P:outer dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000745">
        <property type="entry name" value="Dynein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF7">
        <property type="entry name" value="DYNEIN AXONEMAL INTERMEDIATE CHAIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0243">Dynein</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="261"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG5470084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="601" mass="67825" checksum="6386CD2C37805C1A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GBL0</accession>
    <name>A0A836GBL0_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060620.1">
        <property type="nucleotide sequence ID" value="XM_067205068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GBL0"/>
    <dbReference type="GeneID" id="92359002"/>
    <dbReference type="KEGG" id="loi:92359002"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808">
        <property type="entry name" value="NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808:SF30">
        <property type="entry name" value="SAM-DEPENDENT MTASE RSMB_NOP-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="577"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="585"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5470354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1224" mass="131978" checksum="950EE299223D81C2" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GCU9</accession>
    <name>A0A836GCU9_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_01926</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061002.1">
        <property type="nucleotide sequence ID" value="XM_067203965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GCU9"/>
    <dbReference type="GeneID" id="92357899"/>
    <dbReference type="KEGG" id="loi:92357899"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5472606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="105" mass="11735" checksum="F887CCAA9660548E" modified="2021-09-29" version="1">MERIVRRAARTAPSHHSLQITRERAALPCASLSYAGTWDGPHQMDPRHPLQRIPAGHRSLSLPSGTRARGLVLDSKRAGLALRRSVHRTSSLDLPRVKESHCHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GE71</accession>
    <name>A0A836GE71_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Phosphatidylethanolaminen-methyltransferase-lik e protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_03429</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">LSCM4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060986.1">
        <property type="nucleotide sequence ID" value="XM_067205434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GE71"/>
    <dbReference type="GeneID" id="92359368"/>
    <dbReference type="KEGG" id="loi:92359368"/>
    <dbReference type="UniPathway" id="UPA00753"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004608">
        <property type="term" value="F:phosphatidylethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000023">
        <property type="entry name" value="Phosphatidylethanolaminen-methyltransferase-lik e protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32138">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32138:SF0">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
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</entry>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
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            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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            </authorList>
            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067204008.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="loi:92357942"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="411"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5472649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="619" mass="67537" checksum="05A35F899CB21511" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GFZ0</accession>
    <name>A0A836GFZ0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Meiosis-specific nuclear structural protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LSCM4_02244</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. May play a role in the control of meiotic division and germ cell differentiation through regulation of pairing and recombination during meiosis. Required for sperm flagella assembly. May play a role in the assembly and function of the outer dynein arm-docking complex (ODA-DC). ODA-DC mediates outer dynein arms (ODA) binding onto the axonemal doublet microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Flagellum axoneme</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MNS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061315.1">
        <property type="nucleotide sequence ID" value="XM_067204278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GFZ0"/>
    <dbReference type="SMR" id="A0A836GFZ0"/>
    <dbReference type="GeneID" id="92358212"/>
    <dbReference type="KEGG" id="loi:92358212"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026504">
        <property type="entry name" value="MNS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043597">
        <property type="entry name" value="TPH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19265">
        <property type="entry name" value="MEIOSIS-SPECIFIC NUCLEAR STRUCTURAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19265:SF0">
        <property type="entry name" value="MEIOSIS-SPECIFIC NUCLEAR STRUCTURAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13868">
        <property type="entry name" value="TPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="7 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0282">Flagellum</keyword>
    <keyword evidence="11" id="KW-0469">Meiosis</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trichohyalin-plectin-homology" evidence="15">
        <location>
            <begin position="72"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="255"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF13868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG5472919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="446" mass="52940" checksum="D052A9FA21A6AB31" modified="2021-09-29" version="1">MSFSESRAERLRRVNRYKAVQAELARQKEEEKFAAMRSAKLKAAAVDEALAAELAEQQRLEMKDAKMLQLVRDYPEVRSLESQLKGAYLRKSRAEQVTDRSAAKAQEAEEQRRYMDYLIEQDRLAKAAEEKKHQEDMERFRRHQAEQLEIIRQHRLAALEEAKQREQERIAVDAVVARVQEQDFLETLARRDRQRRIMEEKDEFCRLRAALKKAELDREVKEEAAIRAYLAEQARRREMNEKMARERDAVKARILEEQGRRIAEEEAKKRELESLLQEYYEEERLTKEQMLIEAERASRERMAAAVTRENQQLIEQRRLAKEAEMAEEARFRQETIDKLAAEAKLQKLNRQKEAQIKHQHILEAQQRLEERRLLKEQERELERRVEAQDRKREEQIQEYIRRARAQLLTEHLPKLGSYAPVHAMRDEEKVQFLPQIRSAGAAPPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GGU5</accession>
    <name>A0A836GGU5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA-editing substrate-binding complex 8 protein HEAT repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_00512</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058691.1">
        <property type="nucleotide sequence ID" value="XM_067202590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GGU5"/>
    <dbReference type="SMR" id="A0A836GGU5"/>
    <dbReference type="GeneID" id="92356524"/>
    <dbReference type="KEGG" id="loi:92356524"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058977">
        <property type="entry name" value="RESC8_HEAT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26172">
        <property type="entry name" value="RESC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA-editing substrate-binding complex 8 protein HEAT repeats" evidence="2">
        <location>
            <begin position="192"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="578"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5465060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="601" mass="66251" checksum="F37E7C3CECB467AE" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GGV2</accession>
    <name>A0A836GGV2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Trichohyalin-plectin-homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_00527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058706.1">
        <property type="nucleotide sequence ID" value="XM_067202605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GGV2"/>
    <dbReference type="SMR" id="A0A836GGV2"/>
    <dbReference type="GeneID" id="92356539"/>
    <dbReference type="KEGG" id="loi:92356539"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5465075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="43083" checksum="B10AD370B93AD3C9" modified="2021-09-29" version="1">MPLPPVESGPAGMTRRNYLVELNRLRVSQYAPTRQQLEEEDVRIATARLEEKRTKKAEWTQSLKKAADSYKAADTASGRPLPGGGPRSMRASGKMQPLENIYKLEKEEEAAKKREYNRLYEKEAKHELALREATLKQMHDEESRQIEDLRRLNAEQDRMVAEEHAKAMEEERRYMERLKQSNKRELLARKAKQQEKDARERELQQLVNENSAHREEMEERRRKNAIRMLQLQNELYHREAMKSKQVSDAKRHEEEAALEEYNRRLTKEEQEAALRKKEQFRQDFEDAIARDKEFRRTHNYDEPEELTRQRNELAAHSYRLILQEERLRDAERRQQYRKDLMDQITAKQTFRMTHLDEPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GH57</accession>
    <name>A0A836GH57_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial import inner membrane translocase subunit TIM50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_00725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TIM50 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058901.1">
        <property type="nucleotide sequence ID" value="XM_067202800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GH57"/>
    <dbReference type="SMR" id="A0A836GH57"/>
    <dbReference type="GeneID" id="92356734"/>
    <dbReference type="KEGG" id="loi:92356734"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000171">
        <property type="entry name" value="Nuclear lim interactor-interacting factor,putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="1" id="KW-0811">Translocation</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FCP1 homology" evidence="2">
        <location>
            <begin position="55"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5465270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="292" mass="32833" checksum="1CE8426965BEE50F" modified="2021-09-29" version="1">MPSQRRRGASFRGVYCPDAFPLSLEDSVTETAEVFRRSPSITASGEFLVPAKPTELQNRLTVVLDLDETLIYARQGPLYVRPGIETLMRFLADHCETIVWTSSKHRYADAVVAQIDTCGAVCHTVYRHRRWFNGTSATKELRLLGRDLETTIIVENTPDCCRGYERNAVLVEDYEGGELADHTLHTLLALLRDLVERHENEGITVPEYIATTPRLSQQNVLTDKGTAMQAYCLRGAEDECVVLHSTASKYPCANCGHGASVFPRPAQYPSRMRPAGLLNMKRKYVPQQRVVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GLB9</accession>
    <name>A0A836GLB9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">MGT2 magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_04459</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">LSCM4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062652.1">
        <property type="nucleotide sequence ID" value="XM_067206443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GLB9"/>
    <dbReference type="SMR" id="A0A836GLB9"/>
    <dbReference type="GeneID" id="92360377"/>
    <dbReference type="KEGG" id="loi:92360377"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12829">
        <property type="entry name" value="Alr1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044089">
        <property type="entry name" value="Alr1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF95">
        <property type="entry name" value="MGT2 MAGNESIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="290"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5477241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="412" mass="45804" checksum="50F73070DCC4BC20" modified="2021-09-29" version="1">MMRSKLGGVASDAAAAHKGSLLGFRQRYLTFNRSGGSFWFVRKDVMLKNVQVNQDSVLWVDVEGETPEERRDILNDLPWRVKIPSTVLDAVARPTESDVVELQPKLAQYAYGVLSCAINPLYDTADEAAELEEDNFSGEAFDAARGFVWCSVLITDALIVTMHDKRFLGLEEVVRSLEMRVNPVDAIGLGHMLTPSMVLATLVAYSSEMMLPDPTALLSEVDCIDEMVLLIAPGQRDQPDLLRRVALLRRRISSFRGLLYLKEKLLRELVTPAMRGSLVACDMLHVMPIYKEALEKITQAADRLDDARDILNQANLNFVTGVSMRMSQSSANMDFKMQILSQVAVICLPLNLLASIFGMNCEVPWLAETHPNLNAFWGIIGLMMVWVLISSIPTIRHILRGNAAKAIVPTDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GLM3</accession>
    <name>A0A836GLM3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Electron transfer flavoprotein subunit alpha</fullName>
            <shortName evidence="3">Alpha-ETF</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_03859</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="3 4">Binds 1 FAD per dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061790.1">
        <property type="nucleotide sequence ID" value="XM_067205853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GLM3"/>
    <dbReference type="SMR" id="A0A836GLM3"/>
    <dbReference type="GeneID" id="92359787"/>
    <dbReference type="KEGG" id="loi:92359787"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01715">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000041">
        <property type="entry name" value="Electron transfer flavoprotein alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000048">
        <property type="entry name" value="Electron-transfer-flavoprotein, alpha polypeptide, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033947">
        <property type="entry name" value="ETF_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153:SF1">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
        <property type="entry name" value="Electra_flavoP_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Electron transfer flavoprotein alpha/beta-subunit N-terminal" evidence="5">
        <location>
            <begin position="12"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="237"/>
            <end position="238"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="251"/>
            <end position="255"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="268"/>
            <end position="275"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000089-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5474684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="325" mass="33491" checksum="B319BF0F7FB79CA7" modified="2021-09-29" version="1">MLRATALSLGKALVIAEMVSGKVSPATLSAITAASKVGPVAVLVAGASAKEEAQALAKVESVVSVLAAVGEHYSHGLPEEYAPLIDAAVKANGYTHVFAGTSAFGKNIIPRAAARHGCMPIPEVTEIIDENTFVRQTYAGNAITTVKSSDKVKYCTLRGTAFERAAADGGNATVADLAPTPASGNTRFVEDLLSTSDKPDLMTAASVISGGRGMKNGDNFKMLEELAAPLHAAVGATRAVVDAGYVPNEMQVGQTGKTVAPNFYLACGISGAIQHVAGMKDSKVIAVINTDEDAPFFQIADYGIVDDLFKVVPALTEKIKAAGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GLP1</accession>
    <name>A0A836GLP1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Spliced leader RNA PSE-promoter transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062317.1">
        <property type="nucleotide sequence ID" value="XM_067207014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GLP1"/>
    <dbReference type="GeneID" id="92360948"/>
    <dbReference type="KEGG" id="loi:92360948"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="613"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5476084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="670" mass="74346" checksum="85B144C01A73CB89" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GMD2</accession>
    <name>A0A836GMD2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin-dependent kinases regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_03068</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the CKS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060638.1">
        <property type="nucleotide sequence ID" value="XM_067205086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GMD2"/>
    <dbReference type="SMR" id="A0A836GMD2"/>
    <dbReference type="GeneID" id="92359020"/>
    <dbReference type="KEGG" id="loi:92359020"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.170.10:FF:000006">
        <property type="entry name" value="Cyclin-dependent kinases regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.170.10">
        <property type="entry name" value="Cyclin-dependent kinase, regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000789">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036858">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23415">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01111">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00296">
        <property type="entry name" value="CYCLINKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01084">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55637">
        <property type="entry name" value="Cell cycle regulatory proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00944">
        <property type="entry name" value="CKS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00945">
        <property type="entry name" value="CKS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 4" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU311113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5470372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="99" mass="11784" checksum="5F2AC319A9B44B22" modified="2021-09-29" version="1">MPAKPAQDFFSLDANGQREALIIIKKLQCKILYSDKYYDDTFEYRHVILPKDLARLVPTSRLMSEIEWRQLGVQQSQGWVHYMIHKPEPHVLLFKRPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GQZ0</accession>
    <name>A0A836GQZ0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_04497</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">LSCM4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the exonuclease superfamily. TREX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062690.1">
        <property type="nucleotide sequence ID" value="XM_067206481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GQZ0"/>
    <dbReference type="SMR" id="A0A836GQZ0"/>
    <dbReference type="GeneID" id="92360415"/>
    <dbReference type="KEGG" id="loi:92360415"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06127">
        <property type="entry name" value="DEDDh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000168">
        <property type="entry name" value="Exonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040393">
        <property type="entry name" value="TREX1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13058:SF19">
        <property type="entry name" value="LD40940P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13058">
        <property type="entry name" value="THREE PRIME REPAIR EXONUCLEASE 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="9">
        <location>
            <begin position="89"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="337"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="445"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="350"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="446"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5477279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="510" mass="55504" checksum="5B4A7B9E22355DFB" modified="2021-09-29" version="1">MLRPSYVALRRKVSVVLKGHLNPLEALTQIQLGMTPSLALQRGFLLEHCERQLERLGITEAKLLAMDGRLCTQLTKRIVYELYLSVPFRVFTFDMEFTGPPVFTTDGPTEDITELGLYSPLLDETFSCLVKPVCGRKQGPGVEELTHITDAMLEKEGIPFVEAWQRFLEFVQTPQPDELPGSEKRILLLSHGGKLADVSLIKWTLEKFHMDLPSSFVFGDTIHLIRDAHRRRPVTVDKHPPSWKLVDLVQWLRIPTTLSAHRAGNDARMTWDALYHTLLRYGDDEMTPREQLVPRFFDAEAKQLLREHTARQAQEKDPLGVNGTFLLADAARSASVGCAGSSGNDHSAHRSASSGSGISGSSGATTDLLDLDFDDIFSEQNRVSASAPVEEFKLHDEEGLNSSATEAGDLTASQALSSRAMGSRGVVSVGASEANDAIGDANAVLASTRSSTHTARTATSGGRKRKGPVSSRGKGASEKGSKRSGCASHDCEEASDSPTTTDAAAAVFFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GS36</accession>
    <name>A0A836GS36_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Calcium/potassium channel (CAKC)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LSCM4_06082</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">LSCM4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000020">
        <property type="protein sequence ID" value="KAG5480316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063647.1">
        <property type="nucleotide sequence ID" value="XM_067208007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GS36"/>
    <dbReference type="GeneID" id="92361941"/>
    <dbReference type="KEGG" id="loi:92361941"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005267">
        <property type="term" value="F:potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000223">
        <property type="entry name" value="Ion channel/Calcium-activated BK potassium channel alpha subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003929">
        <property type="entry name" value="K_chnl_BK_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047871">
        <property type="entry name" value="K_chnl_Slo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048735">
        <property type="entry name" value="Slowpoke-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027:SF10">
        <property type="entry name" value="SLOWPOKE 2, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03493">
        <property type="entry name" value="BK_channel_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21014">
        <property type="entry name" value="Slowpoke_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="14">
        <location>
            <begin position="262"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium-activated potassium channel BK alpha subunit" evidence="13">
        <location>
            <begin position="481"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="Ca2+-activated K+ channel Slowpoke-like C-terminal" evidence="15">
        <location>
            <begin position="1042"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="69"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="661"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="679"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF21014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG5480316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1108" mass="126556" checksum="C7ABD675C73B52AE" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GSZ6</accession>
    <name>A0A836GSZ6_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_08062</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000005">
        <property type="protein sequence ID" value="KAG5487617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065905.1">
        <property type="nucleotide sequence ID" value="XM_067209938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GSZ6"/>
    <dbReference type="GeneID" id="92363872"/>
    <dbReference type="KEGG" id="loi:92363872"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5487617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="393" mass="44913" checksum="3D9E408BEAF2C15C" modified="2021-09-29" version="1">MSSGASARAPFTHGGAGRAIKTRVKSNIGQPYAKRFYNSVWTYRVAQLTTSNVRHMKKSSIDFGIDIGGGSGPELPVKSDLQPHALHKFTGETDWSIIVAVPKNSEHVRNLQDCAKGSLMLGHTDPQLFHWFKELGALPPRSLLSGSMELLRGDLQAEAWEQTFSRHPIIHRIAQDMWESDESKTAEEAVHIAKREQEEDEKRMRRMSSSDWRAKFRERERNPTRAEDEEAPVYVIKPETFSLFRMKPDVRLWMNTAGQTQRVWDPVVPDPDPLCRCSHRFIRMLNLGRQKLVPSLNMNYSLKLTNAFIFEISDSGMWAMGTQENLAGKNGIVKEEWMELRLDFGKNQIITTEQEMEWWVRGLTKLGAPELSQTNSSVEDAGLSPEDFEYRHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GTA2</accession>
    <name>A0A836GTA2_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_05720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063425.1">
        <property type="nucleotide sequence ID" value="XM_067207652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GTA2"/>
    <dbReference type="SMR" id="A0A836GTA2"/>
    <dbReference type="GeneID" id="92361586"/>
    <dbReference type="KEGG" id="loi:92361586"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5479714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="151" mass="18403" checksum="A69F7ACCF9F18364" modified="2021-09-29" version="1">MLRISSARFPKAGCEEITRRARRIVLKPQEYYAQHRMQVWQMRFKEMGPPFSRVWVALGGKMRRRRIGRQIDVKDMRYYWRPIEPQYQRLYMSRLRLKDHSNKRLQPMRLRATNSDIGHASSLKEWERSSDRKYGAALAPPKRRDFEFRVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GUD7</accession>
    <name>A0A836GUD7_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_02751</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060324.1">
        <property type="nucleotide sequence ID" value="XM_067204772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GUD7"/>
    <dbReference type="SMR" id="A0A836GUD7"/>
    <dbReference type="GeneID" id="92358706"/>
    <dbReference type="KEGG" id="loi:92358706"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20558">
        <property type="entry name" value="CYCLIN_ScPCL7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF108">
        <property type="entry name" value="PROTEIN CNPPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5470058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="277" mass="30219" checksum="40FE85E5B3AD1486" modified="2021-09-29" version="1">MISIPVMTDETVVRYHSSMNASGAAAEENGDYQATVDAAGRGNGGEAATAAAVPPAAMGYYAQSFSSPPFFRGGGVPAASAQYNAAIPCSCSILDVGADPAPIAAPVDVAPPEMPPLAQLCALALQYRCDLSHEMDQNIRSCFHSSRVPSISLWDYVRRFAKYSNCSEECFVLAIVLMDRYVCKTKIPITLRNVHRLYITAMTLSVKLRDDSYYSNAYYASIGGVVNAELNVLELELLDIVHWFTWVEKSVFDAYVMRLEALFQVAMPKRLVASSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GUM1</accession>
    <name>A0A836GUM1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_06231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000020">
        <property type="protein sequence ID" value="KAG5480464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063795.1">
        <property type="nucleotide sequence ID" value="XM_067208155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GUM1"/>
    <dbReference type="GeneID" id="92362089"/>
    <dbReference type="KEGG" id="loi:92362089"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10527">
        <property type="entry name" value="SET_LSMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF136">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5480464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="37212" checksum="2FA3F2E83E85E615" modified="2021-09-29" version="1">MLQHSLARLAATAAASADASGETLAPFTARVGALCKQMHAAGAELSCVAVDPNEEQCRGIVAKCAIREGTTVISVPLQRCGISSEQLNENAFVKAMKPPSLDVVRHLMNARSIRDPVMHEQLFLALLVAADRMNPASPRSNYYDLLPHPAIDDAAVIQRHKDVLDPLLLVEWDDYQKEMLSILHQLLRRWNSPLAPPVQVAYWAMRTVLSRMHMLPKAGLAPQQMGSTLSYTALSTVDQANLQTRWRRRFKSMLSSLTGSPADAEEYHLVPTLVPLLDMTPHIPSSNVQVEVNTRDSSVGGCAELRAVRDIDAGETIGLRFNASQGAAFLLFRFGFIPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GV05</accession>
    <name>A0A836GV05_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_06907</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000017">
        <property type="protein sequence ID" value="KAG5481831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064191.1">
        <property type="nucleotide sequence ID" value="XM_067208817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GV05"/>
    <dbReference type="GeneID" id="92362751"/>
    <dbReference type="KEGG" id="loi:92362751"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5481831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="387" mass="42032" checksum="0B394E25FBB11BE5" modified="2021-09-29" version="1">MANEDIIIYLDAMQNTVSMIRGDGSDKRTLFSTGCMCPDGIVLDLSKYKESKDPKDIIVWWGNMGCMKPCPGSGDGGDWHEADGFLSRGMLFGGDTTVERVEVNPPRHLVQGTAEYQAPANLALITTVKQLDITLNGNCIFFCDREGHGVKKYNVMTKELVMLLSSDSLAPFQCGIPGRAGASSEEPSCEEECRFCVGIALDEGHNCIFFTLKGPPKGGKGRILTFPYCFKCRNLPSTTAAKTSAAEGVVDPETVVSLIDNQPEPVDLLLDAQQGSLYWTDRGDDKAGGNSLNRCSVGYDRRTGQPQLGGKELLVGGFNEPIGLAWAGSLEGRIPLPPGSKETLRDNMYVSDKDHLWRCNLRNGERVSILDCGPDSRPTGLAVLRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GVZ4</accession>
    <name>A0A836GVZ4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinetoplast DNA-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_00631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058809.1">
        <property type="nucleotide sequence ID" value="XM_067202708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GVZ4"/>
    <dbReference type="SMR" id="A0A836GVZ4"/>
    <dbReference type="GeneID" id="92356642"/>
    <dbReference type="KEGG" id="loi:92356642"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052695">
        <property type="entry name" value="Kinetoplast-DNA-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37564:SF1">
        <property type="entry name" value="DNA-ASSOCIATED PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37564">
        <property type="entry name" value="KINETOPLAST DNA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5465178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="165" mass="18755" checksum="EA9744F315B2472B" modified="2021-09-29" version="1">MFRAARLLRGVSPFSIFLMDQKNNPALQGVSIAKRGKILSKMYKELSQQQRRDLQKRAQVHPGLRKAKRAKPPRKTEFAEFVRQNYNVVKGLNYRKRFSALSQLYELHKPLEVQVTKALKEANAKKVTPAKTVVKKAAANPQSASTLKAKKALKKSRGTQVVKRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GWD9</accession>
    <name>A0A836GWD9_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_07075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
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                <person name="Bates M.D."/>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000016">
        <property type="protein sequence ID" value="KAG5482414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064420.1">
        <property type="nucleotide sequence ID" value="XM_067207606.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836GYC5"/>
    <dbReference type="GeneID" id="92361540"/>
    <dbReference type="KEGG" id="loi:92361540"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="657"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="805"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2504"/>
            <end position="2531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2597"/>
            <end position="2619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3043"/>
            <end position="3072"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3309"/>
            <end position="3347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3425"/>
            <end position="3447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3523"/>
            <end position="3566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3715"/>
            <end position="3736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="658"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2504"/>
            <end position="2516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="3043"/>
            <end position="3061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="3328"/>
            <end position="3339"/>
        </location>
    </feature>
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        <location>
            <begin position="3523"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="3719"/>
            <end position="3728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5482414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="3754" mass="400550" checksum="E167C8BE13ADAC31" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GYE2</accession>
    <name>A0A836GYE2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ras-related protein rab-5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_07116</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000018">
        <property type="protein sequence ID" value="KAG5481404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064083.1">
        <property type="nucleotide sequence ID" value="XM_067209020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GYE2"/>
    <dbReference type="SMR" id="A0A836GYE2"/>
    <dbReference type="GeneID" id="92362954"/>
    <dbReference type="KEGG" id="loi:92362954"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01860">
        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002076">
        <property type="entry name" value="Ras-related protein rab-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="208"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5481404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="25157" checksum="9DF6FABBAAD3483B" modified="2021-09-29" version="1">MNAHPPQLMEATSAKIVMLGESGAGKSSIALRFTRNEFLANQETTIGAAFLSKTVMIPPSRGAAAAPGGAASTHALQQQMRALKYEIWDTAGQERFRSLAPIYYRGACGALVVYDITNSESLKKAQTWIRELRANADPSLIIVLVGNKKDLESLRQVSFEDGQRLAAEEQLAAFYETSAKDNSNVEQAFLDLAGKLLDQGLGSRGGAAGGARGGVLAPRGEHVEQRTESAAQSTCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GYN0</accession>
    <name>A0A836GYN0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_05217</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062470.1">
        <property type="nucleotide sequence ID" value="XM_067207167.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92361101"/>
    <dbReference type="KEGG" id="loi:92361101"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001848">
        <property type="entry name" value="Protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050205">
        <property type="entry name" value="CDPK_Ser/Thr_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24349">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="627"/>
            <end position="1433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="114"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="428"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="518"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="566"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="668"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1055"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1158"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1448"/>
            <end position="1481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1586"/>
            <end position="1659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1725"/>
            <end position="1759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="526"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="585"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="671"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1055"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1072"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1173"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1592"/>
            <end position="1607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1747"/>
            <end position="1756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5476237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1775" mass="186322" checksum="0B6C60C6C525CF13" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GZT6</accession>
    <name>A0A836GZT6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_00854</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059572.1">
        <property type="nucleotide sequence ID" value="XM_067202922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GZT6"/>
    <dbReference type="SMR" id="A0A836GZT6"/>
    <dbReference type="GeneID" id="92356856"/>
    <dbReference type="KEGG" id="loi:92356856"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23799">
        <property type="entry name" value="UBCc_UBE2J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="7"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5467770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="290" mass="31710" checksum="C7BA9E1D048B8B29" modified="2021-09-29" version="1">MTAPTAQCLKRLQIELRKLHTEWELPFRVGADPQNMLRCYFVVDGPAGTPYEGGRYVGLLEIPSDYPFKPPSVQMCTPSGRLKTGMQICLSNSSYHPENWSPMWGLRTILLALVSFFVSEEPTTGSMRATAEERREYAANSRKYNVKRLHTVYKRVLPDAFAADSAFIEKDGMSSNGEGGSSSGGGSDGEATEAEEAQIGVESKVAAQERTTSHETIAAPAEKAPDGGKMEAADTDTAAAAERPRHHRHHELKKSTTGAVAERGGQLQWRRYASLLVLLAIGLGVLRQLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GZX8</accession>
    <name>A0A836GZX8_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_07933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000013">
        <property type="protein sequence ID" value="KAG5484366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064859.1">
        <property type="nucleotide sequence ID" value="XM_067209809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GZX8"/>
    <dbReference type="GeneID" id="92363743"/>
    <dbReference type="KEGG" id="loi:92363743"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5484366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="327" mass="36083" checksum="8A33B8DD854DD433" modified="2021-09-29" version="1">MRYRQSNHNVANRDQHARALIDANDFLSTSEQEEVIAFLARSLRGSTQLLKVVTCLQAVLALVYTFLLCSGSLLIDVLIDLAATASLVQLGGQQQQDSQRQAAPAATPTALSKAPLEALAALDATQRDAQRKYVHDYMSHRTATEAGFRAGGVMAVLSAVVMLYSIALLWWSAWSCYEACRQLRVNVEDLTRTEPRDLSRRHLEECPSPAAMAAKPRPTLRHLRQRVKADPAVAQRVAAALASLGSLFWLSALVHRQRATKSVYADLGLQPPSVLSLQKITNAALEYILAVWQPLFHLGTGLLVRSMLGTRENLVALSKLKYRFDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H0I8</accession>
    <name>A0A836H0I8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Deoxyhypusine synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_00792</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the deoxyhypusine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059515.1">
        <property type="nucleotide sequence ID" value="XM_067202865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H0I8"/>
    <dbReference type="SMR" id="A0A836H0I8"/>
    <dbReference type="GeneID" id="92356799"/>
    <dbReference type="KEGG" id="loi:92356799"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034038">
        <property type="term" value="F:deoxyhypusine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.910.10">
        <property type="entry name" value="Deoxyhypusine synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002773">
        <property type="entry name" value="Deoxyhypusine_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036982">
        <property type="entry name" value="Deoxyhypusine_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703:SF1">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01916">
        <property type="entry name" value="DS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="567"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="576"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5467713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="602" mass="65000" checksum="93D5C55632C922A9" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H132</accession>
    <name>A0A836H132_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Small nuclear ribonucleoprotein Sm D3</fullName>
            <shortName evidence="9">Sm-D3</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">snRNP core protein D3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_01115</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the snRNP core protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5468028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059830.1">
        <property type="nucleotide sequence ID" value="XM_067203180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H132"/>
    <dbReference type="SMR" id="A0A836H132"/>
    <dbReference type="GeneID" id="92357114"/>
    <dbReference type="KEGG" id="loi:92357114"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01721">
        <property type="entry name" value="Sm_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000058">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034099">
        <property type="entry name" value="SmD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="5"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5468028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="113" mass="12352" checksum="74BE63B8CFE9A106" modified="2021-09-29" version="1">MAESIPMKVLFDALHLKVSIEVATGEVYHGTVEELQNNMNVLLKDATKTTRSGKETKMDSVFVRGSNIVFFQLPDALQTSPALLRAGEVVSKAKDTRGDGKGFGASRKRLRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H151</accession>
    <name>A0A836H151_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ER membrane protein complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LSCM4_01146</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5468058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059860.1">
        <property type="nucleotide sequence ID" value="XM_067203210.1"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A836H151"/>
    <dbReference type="GeneID" id="92357144"/>
    <dbReference type="KEGG" id="loi:92357144"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026895">
        <property type="entry name" value="EMC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011678">
        <property type="entry name" value="EMC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21573">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21573:SF0">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07774">
        <property type="entry name" value="EMC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032558381" description="ER membrane protein complex subunit 1" evidence="12">
        <location>
            <begin position="26"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="789"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="domain" description="ER membrane protein complex subunit 1 C-terminal" evidence="13">
        <location>
            <begin position="598"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG5468058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="818" mass="87290" checksum="4A3F2C45A864EC80" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H1B5</accession>
    <name>A0A836H1B5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MIF4G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_07173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000015">
        <property type="protein sequence ID" value="KAG5482964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064460.1">
        <property type="nucleotide sequence ID" value="XM_067209077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H1B5"/>
    <dbReference type="SMR" id="A0A836H1B5"/>
    <dbReference type="GeneID" id="92363011"/>
    <dbReference type="KEGG" id="loi:92363011"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000086">
        <property type="entry name" value="Eukaryotic initiation factor 4a, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253:SF73">
        <property type="entry name" value="MIF4G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G" evidence="2">
        <location>
            <begin position="199"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5482964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1016" mass="113633" checksum="30E5218E2747B259" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H355</accession>
    <name>A0A836H355_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060272.1">
        <property type="nucleotide sequence ID" value="XM_067204720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H355"/>
    <dbReference type="GeneID" id="92358654"/>
    <dbReference type="KEGG" id="loi:92358654"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="392"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5470006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="471" mass="52133" checksum="9BF5135F6BFDB007" modified="2021-09-29" version="1">MIRDQCHAYCQCAYCAQKPQERSYNTGASMWAAMESLNRPGMSKDELYMKSLRQSLRAKALLDSSKNAGKFIPDEQLLSSMKRREAKELALTAELVPVRRRDRLQELLLLEHKNRLREEAALRAQRRALGLPDEEDEPISAPHSESPASTRPSSKQSLQQCLSSGAATPASRCSAEHDLHVMLKGIKDIVEEDPAASSDPLNHEQVYKLRQLMHTQKKKTREMINSCENQPHVCGHCLDVDVQARHLSAAPHGSVAFGLTGKIINPEEGIKFGTTAARGFDGTYDASAVDPALVSGNKSRLSSYNAHPYGTGMVFLPVPSLRQASRHSTGNHSTRFRATFNNNIGREEPVDAELQFPGSTYNVYDTGFEKETTPQVAAKSGKGERTVKIDTASSNMSSQNAANEPRADAVAAAPAAPEQPAYTSSTAMWMTTNQDRELDMKRFVEFQQRMRENSKRVYAETASRFKKAVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H4Q9</accession>
    <name>A0A836H4Q9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Glycylpeptide N-tetradecanoyltransferase</fullName>
            <ecNumber evidence="2 5">2.3.1.97</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_02666</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>N-terminal glycyl-[protein] + tetradecanoyl-CoA = N-tetradecanoylglycyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15521"/>
            <dbReference type="Rhea" id="RHEA-COMP:12666"/>
            <dbReference type="Rhea" id="RHEA-COMP:12667"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:64723"/>
            <dbReference type="ChEBI" id="CHEBI:133050"/>
            <dbReference type="EC" id="2.3.1.97"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the NMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.97" evidence="2 5"/>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5469978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060244.1">
        <property type="nucleotide sequence ID" value="XM_067204692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H4Q9"/>
    <dbReference type="SMR" id="A0A836H4Q9"/>
    <dbReference type="GeneID" id="92358626"/>
    <dbReference type="KEGG" id="loi:92358626"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004379">
        <property type="term" value="F:glycylpeptide N-tetradecanoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.170:FF:000004">
        <property type="entry name" value="Glycylpeptide N-tetradecanoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000903">
        <property type="entry name" value="NMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022677">
        <property type="entry name" value="NMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022678">
        <property type="entry name" value="NMT_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022676">
        <property type="entry name" value="NMT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377:SF5">
        <property type="entry name" value="GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377">
        <property type="entry name" value="N-MYRISTOYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01233">
        <property type="entry name" value="NMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02799">
        <property type="entry name" value="NMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015892">
        <property type="entry name" value="N-myristl_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00975">
        <property type="entry name" value="NMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00976">
        <property type="entry name" value="NMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycylpeptide N-tetradecanoyltransferase N-terminal" evidence="8">
        <location>
            <begin position="36"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Glycylpeptide N-tetradecanoyltransferase C-terminal" evidence="9">
        <location>
            <begin position="229"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5469978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="421" mass="48765" checksum="32ACCC616638C09A" modified="2021-09-29" version="1">MSRTPPHPEGGHAFWSTQPVPQTEDETETVVFAGPMDEPKTIADIPEEPYPIASTFEWWTPNMEAADDIHAIYELLRDNYVEDDDSMFRFNYSEEFLQWALCPPNYIPDWHVAVRRKADKKLLAFIAGVPVTLRMGTPRHMQLKAQERGQGEAAAKYDEPRHICEINFLCVHKQLREKRLAPILIKEVTRRVNRKDVWQAVYTAGVLLPTPYASGQYFHRSLNPEKLVEIRFSSIPMQYQKFQNPMAMLKRNYQLPSTPKNSGLREMKPSDVPQVRRILMNYLEKFDVGPVFSEPEIGHYLLPRNGVVFTYVVENDKKVTDFFSFYRIPSTVIGNSTYNMLNAAYVHYYAATSMPLHQLILDLLIVAHSRGFDVCNMVEILDNRSFLETLKFGAGDGYLRYYFYNWAYPKIKPSQVALVML</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H5F3</accession>
    <name>A0A836H5F3_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063563.1">
        <property type="nucleotide sequence ID" value="XM_067207790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H5F3"/>
    <dbReference type="GeneID" id="92361724"/>
    <dbReference type="KEGG" id="loi:92361724"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.20">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="561"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5479852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="604" mass="63227" checksum="C61246A7FD239DCB" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H5U0</accession>
    <name>A0A836H5U0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_04205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062131.1">
        <property type="nucleotide sequence ID" value="XM_067206194.1"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A836H5U0"/>
    <dbReference type="GeneID" id="92360128"/>
    <dbReference type="KEGG" id="loi:92360128"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052394">
        <property type="entry name" value="LRR-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5475623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="399" mass="42026" checksum="1123CAD6BAA3AB31" modified="2021-09-29" version="1">MTTMVDYAAGVDDPASTSSQLFLTAYEEEAPRYKPPEELLAERQQALKRYQYAIPDDPESDASGANAYLAMCAAIAKTTGTNGPTNSIAKDLAAESEVLDLSYAGLGVNGCAALAAALRVTSAVQSLILVGNYITPSAAQELVRAINDTRSIQSLNLSKNQLGRVEAMRKGVHSLTTISGGAVVNEALALGSTLRSLALADNHLGDTDVSAFSETLAENITLLELDLSYNRIGFVGASELAKVLSRNSDLRVLNMEWNPLRAAGAYLFLSEGLLQNNTIKQCNLSSCGLDDKCGQLVARVVSENAIEEVIIANNRIGRVGAEAIARTLPSSSALTTLVMDGNPIGDAGSAALLDVVLSGIVSTLRVMSLQHCSCSDLAIVRRGEEASSETLTIRISESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H6H4</accession>
    <name>A0A836H6H4_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000010">
        <property type="protein sequence ID" value="KAG5485664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065248.1">
        <property type="nucleotide sequence ID" value="XM_067208537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H6H4"/>
    <dbReference type="GeneID" id="92362471"/>
    <dbReference type="KEGG" id="loi:92362471"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5485664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="751" mass="79004" checksum="CA0EA24D89B161CD" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H8K5</accession>
    <name>A0A836H8K5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_07523</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAFHLR010000004">
        <property type="protein sequence ID" value="KAG5487844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066041.1">
        <property type="nucleotide sequence ID" value="XM_067209409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H8K5"/>
    <dbReference type="GeneID" id="92363343"/>
    <dbReference type="KEGG" id="loi:92363343"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FHA" evidence="7">
        <location>
            <begin position="168"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="396"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="120"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="612"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="723"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1022"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5487844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1232" mass="133856" checksum="E29F3CB28449D37D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H9S4</accession>
    <name>A0A836H9S4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061119.1">
        <property type="nucleotide sequence ID" value="XM_067204082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H9S4"/>
    <dbReference type="SMR" id="A0A836H9S4"/>
    <dbReference type="GeneID" id="92358016"/>
    <dbReference type="KEGG" id="loi:92358016"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050910">
        <property type="entry name" value="JMJD6_ArgDemeth/LysHydrox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480">
        <property type="entry name" value="ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480:SF21">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="1">
        <location>
            <begin position="416"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5472723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="627" mass="69984" checksum="019F3108D7FBC691" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HAM2</accession>
    <name>A0A836HAM2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Signal recognition particle 54 kDa protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LSCM4_05358</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The M domain binds the 7SL RNA in presence of SRP19 and binds the signal sequence of presecretory proteins.</text>
    </comment>
    <comment type="domain">
        <text evidence="13">The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit SRPRA. The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another. SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5477963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062870.1">
        <property type="nucleotide sequence ID" value="XM_067207302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HAM2"/>
    <dbReference type="SMR" id="A0A836HAM2"/>
    <dbReference type="GeneID" id="92361236"/>
    <dbReference type="KEGG" id="loi:92361236"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006616">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17875">
        <property type="entry name" value="SRP54_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000022">
        <property type="entry name" value="Signal recognition particle 54 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="entry name" value="Signal recognition particle, SRP54 subunit, M-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006325">
        <property type="entry name" value="SRP54_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01425">
        <property type="entry name" value="SRP54_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 54K PROTEIN SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF5">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="Domain of the SRP/SRP receptor G-proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="Signal peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10 13" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="14">
        <location>
            <begin position="269"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG5477963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="518" mass="56479" checksum="9CC0CE38CEF35501" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HAM8</accession>
    <name>A0A836HAM8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">STI1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_03473</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061413.1">
        <property type="nucleotide sequence ID" value="XM_067205476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HAM8"/>
    <dbReference type="GeneID" id="92359410"/>
    <dbReference type="KEGG" id="loi:92359410"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.100:FF:000014">
        <property type="entry name" value="Hsc70-interacting protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:002618">
        <property type="entry name" value="Hsc70-interacting protein (Hip), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041243">
        <property type="entry name" value="STI1/HOP_DP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006636">
        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45883">
        <property type="entry name" value="HSC70-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45883:SF2">
        <property type="entry name" value="HSC70-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17830">
        <property type="entry name" value="STI1-HOP_DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00727">
        <property type="entry name" value="STI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="STI1" evidence="4">
        <location>
            <begin position="293"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="44"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="221"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="359"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="243"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="376"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5473410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="386" mass="40813" checksum="4304955910B3B259" modified="2021-09-29" version="1">MSSYSAADVAALNRTLAALRAQPDDIHCPQLAALKAWATEVGASFPAPTAPSAPAESAEPKCDDESEPDEERWTLSDAEPAAIPAKCGEPSDADVDAAVAAKAEAAELHSDGKKEEAIAKMGEALTFNPNNAMYWGLRALYHLEYEKPRAALHDANKALELNPQNVRALRVRGTVNRHLGHWEDSLKDLSAAQAVDYDEKTNETLKYVQHRAMERHKRELARQRAKEEAAERRQEELRRQRQQEAAAAAAEARAASDGMPGGTPGGMPRAFPAGMPGGMPGAMPPGMESILQDPDIVAAMQDPEVGPKLTQMMQNPMAAMSLMNDPKVGPVMQKIMSKMMGGGGMPGAMGGMGGGMPGGFPGAGGMPSHGCASSGAARSTPQDDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HAX3</accession>
    <name>A0A836HAX3_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061533.1">
        <property type="nucleotide sequence ID" value="XM_067205596.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92359530"/>
    <dbReference type="KEGG" id="loi:92359530"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5473530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1378" mass="150107" checksum="BE809B0283BC0669" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HBU7</accession>
    <name>A0A836HBU7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein S29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_04013</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061942.1">
        <property type="nucleotide sequence ID" value="XM_067206005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HBU7"/>
    <dbReference type="SMR" id="A0A836HBU7"/>
    <dbReference type="GeneID" id="92359939"/>
    <dbReference type="KEGG" id="loi:92359939"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.830.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.10">
        <property type="entry name" value="30s Ribosomal Protein S14, Chain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_uS14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039744">
        <property type="entry name" value="RIbosomal_uS14_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043140">
        <property type="entry name" value="Ribosomal_uS14_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004424">
        <property type="entry name" value="PRK05766.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12010">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12010:SF2">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5474836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="57" mass="6650" checksum="F482F3C197D9C89F" modified="2021-09-29" version="1">MGHLDQWRSHQKIGMGKGSRCCVICSNQKALIRKYELNVCRQCFRENAEHIGFAKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HDG9</accession>
    <name>A0A836HDG9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_04044</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061971.1">
        <property type="nucleotide sequence ID" value="XM_067206034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HDG9"/>
    <dbReference type="SMR" id="A0A836HDG9"/>
    <dbReference type="GeneID" id="92359968"/>
    <dbReference type="KEGG" id="loi:92359968"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1900:FF:000020">
        <property type="entry name" value="Spindle pole body component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF14">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="8">
        <location>
            <begin position="230"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="511"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="94"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="149"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="114"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5474865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="827" mass="91950" checksum="9C565DC1586D4755" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HE05</accession>
    <name>A0A836HE05_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_07994</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000013">
        <property type="protein sequence ID" value="KAG5484427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064920.1">
        <property type="nucleotide sequence ID" value="XM_067209870.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836HE05"/>
    <dbReference type="GeneID" id="92363804"/>
    <dbReference type="KEGG" id="loi:92363804"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1237"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="738"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1009"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="740"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5484427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1313" mass="139534" checksum="5E5CB62031327CD7" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HF41</accession>
    <name>A0A836HF41_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CCT-beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_04200</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062126.1">
        <property type="nucleotide sequence ID" value="XM_067206189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HF41"/>
    <dbReference type="SMR" id="A0A836HF41"/>
    <dbReference type="GeneID" id="92360123"/>
    <dbReference type="KEGG" id="loi:92360123"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03336">
        <property type="entry name" value="TCP1_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000025">
        <property type="entry name" value="Chaperonin containing TCP1 subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000002">
        <property type="entry name" value="T-complex protein 1 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012716">
        <property type="entry name" value="Chap_CCT_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02341">
        <property type="entry name" value="chap_CCT_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0346">Stress response</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5475618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="529" mass="57705" checksum="7A36B92609CB2E5F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HIM9</accession>
    <name>A0A836HIM9_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_07599</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000012">
        <property type="protein sequence ID" value="KAG5484830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064942.1">
        <property type="nucleotide sequence ID" value="XM_067209482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HIM9"/>
    <dbReference type="GeneID" id="92363416"/>
    <dbReference type="KEGG" id="loi:92363416"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23680">
        <property type="entry name" value="RESC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5484830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="481" mass="51474" checksum="7B6F54A376855932" modified="2021-09-29" version="1">MRRFTARLQPLTFEALLCGAQTVLPPPMHLPAACARAKEEFASQCSTSAPPPTMLTTAAVVTHFLQNNLRDAAAVLASHPCRQQVLQGVREYVARHPGALAVATLTGMSEEVRCVGEDAVAAFLCVAVEQFVCDSSAAAVEGDEAAARDAQRESLRSLVLRHIRLHPACASALLGSLCSVSRGCAGDREDVINVMQLAIRERSINPRDFGSVLDVVWKSGEPRRVAMMWGWMQHTSACWDIRAASVAIMAFSALQQVDEAVACMQKLAEADCDPTISAQVAFIRFIGAQASALLPYAARLVLHWHPSDERLWRGEAQAVGMELVKACGACGEGKAAVEMLERMVATNAGMPAELDAFMLRPGAAAVGELYGASVVTSKPLQDLFIEVPLRLPCLGETPELVGLLLSLGMAADRLSEVYNALERVSLTPANFHSALDCFTKGRVAKAASPAAVLACVREVSVRTGNAAPKEMESWLQLATEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HIS7</accession>
    <name>A0A836HIS7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SMP-LTD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_07678</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000012">
        <property type="protein sequence ID" value="KAG5484905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065017.1">
        <property type="nucleotide sequence ID" value="XM_067209557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HIS7"/>
    <dbReference type="GeneID" id="92363491"/>
    <dbReference type="KEGG" id="loi:92363491"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21675">
        <property type="entry name" value="SMP_TEX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466:SF0">
        <property type="entry name" value="SMP-LTD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466">
        <property type="entry name" value="TEX2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="201"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="330"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="698"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="285"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="737"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="810"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="848"/>
            <end position="869"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5484905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="944" mass="99170" checksum="B6C25D85452EBC84" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HL57</accession>
    <name>A0A836HL57_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_08329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000001">
        <property type="protein sequence ID" value="KAG5488252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066299.1">
        <property type="nucleotide sequence ID" value="XM_067210198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HL57"/>
    <dbReference type="GeneID" id="92364132"/>
    <dbReference type="KEGG" id="loi:92364132"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5488252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="147" mass="16617" checksum="BE1595AAAC41DC0C" modified="2021-09-29" version="1">MLFRRICVVRPLVLRAREMSMKTVVVEHGAPLSLYYFITNELLVCLLTYLLHYGYFGKEDLIGLLKCIGASKYIDLSSIEGKSWSLFDGQLVVSARLVANFTAASIFMSLWTPVQLPICIATYPYLKRISQRWMKRGSASRPTQSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HMM3</accession>
    <name>A0A836HMM3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">P-type ATPase A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LSCM4_06368</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000007">
        <property type="protein sequence ID" value="KAG5486900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065694.1">
        <property type="nucleotide sequence ID" value="XM_067208289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HMM3"/>
    <dbReference type="SMR" id="A0A836HMM3"/>
    <dbReference type="GeneID" id="92362223"/>
    <dbReference type="KEGG" id="loi:92362223"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000098">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000187">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000378">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF7">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE HELIX TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1053"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1090"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1142"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1172"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1213"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="12">
        <location>
            <begin position="268"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG5486900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1238" mass="138972" checksum="21536A61B7DEFDDD" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HMZ5</accession>
    <name>A0A836HMZ5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="5">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_05778</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="5">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="5"/>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063481.1">
        <property type="nucleotide sequence ID" value="XM_067207708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HMZ5"/>
    <dbReference type="GeneID" id="92361642"/>
    <dbReference type="KEGG" id="loi:92361642"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="100"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="403"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="233"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="447"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="466"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5479770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="701" mass="76025" checksum="ABA57ED7B0C15B0B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HPK4</accession>
    <name>A0A836HPK4_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000020">
        <property type="protein sequence ID" value="KAG5480388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063719.1">
        <property type="nucleotide sequence ID" value="XM_067208079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HPK4"/>
    <dbReference type="GeneID" id="92362013"/>
    <dbReference type="KEGG" id="loi:92362013"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 20"/>
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                <person name="Al-Salem W.S."/>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Bates M.D."/>
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                <person name="Bates M.D."/>
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            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5481423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="818" mass="91011" checksum="BE19D2BB5DD83858" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HUZ1</accession>
    <name>A0A836HUZ1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sulfhydryl oxidase</fullName>
            <ecNumber evidence="6">1.8.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_07272</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2</text>
            <dbReference type="Rhea" id="RHEA:17357"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16520"/>
            <dbReference type="ChEBI" id="CHEBI:17412"/>
            <dbReference type="EC" id="1.8.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="6"/>
    <dbReference type="EMBL" id="JAFHLR010000015">
        <property type="protein sequence ID" value="KAG5483058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064554.1">
        <property type="nucleotide sequence ID" value="XM_067209171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HUZ1"/>
    <dbReference type="SMR" id="A0A836HUZ1"/>
    <dbReference type="GeneID" id="92363105"/>
    <dbReference type="KEGG" id="loi:92363105"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016971">
        <property type="term" value="F:flavin-dependent sulfhydryl oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.310:FF:000008">
        <property type="entry name" value="Sulfhydryl oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.310">
        <property type="entry name" value="ERV/ALR sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039799">
        <property type="entry name" value="ALR/ERV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036774">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645">
        <property type="entry name" value="ALR/ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645:SF0">
        <property type="entry name" value="FAD-LINKED SULFHYDRYL OXIDASE ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04777">
        <property type="entry name" value="Evr1_Alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69000">
        <property type="entry name" value="FAD-dependent thiol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51324">
        <property type="entry name" value="ERV_ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 6" id="KW-0274">FAD</keyword>
    <keyword evidence="2 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="8">
        <location>
            <begin position="16"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="139"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="207"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="142"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="221"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU371123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5483058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="315" mass="35200" checksum="E648CB016628FCB9" modified="2021-09-29" version="1">MPEGEEYERLTTIPGECPTPLELGVSGWNILHSSAAVYPYKPSAVQQAAMKNFIESWAHVYACSWCAYHMREYVRDHPPDVRDKLTVSRYVCEMHNEVSQRLGKDVFDCSPHVVLRRWHPGYPNKMEDVPTIEEQLAASHRAKSEVVEAKPRQQEEERRFRERGLHTRDTAPKDAASWRNAHEAAPTKADGRPWGWRLFSRAALRAPAAKDNAPPGWGSSAPPTTAQRPQTDPFTGARETPSTSVAATAAVDVASVSAAPLRHSWAASTSEVHDSFLTPAPSRGKTANEDTDIDAVLERLKRCQVYCPEDEELKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836I0A0</accession>
    <name>A0A836I0A0_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_06671</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000010">
        <property type="protein sequence ID" value="KAG5485713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065297.1">
        <property type="nucleotide sequence ID" value="XM_067208586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836I0A0"/>
    <dbReference type="SMR" id="A0A836I0A0"/>
    <dbReference type="GeneID" id="92362520"/>
    <dbReference type="KEGG" id="loi:92362520"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039902">
        <property type="entry name" value="CCDC148/CCDC112"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21549:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21549">
        <property type="entry name" value="MUTATED IN BLADDER CANCER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="420"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="545"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="20"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="321"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5485713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="567" mass="63618" checksum="A8B5F5C24BF93CE2" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KAA1</accession>
    <name>A0A836KAA1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_02450</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060031.1">
        <property type="nucleotide sequence ID" value="XM_067204479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KAA1"/>
    <dbReference type="SMR" id="A0A836KAA1"/>
    <dbReference type="GeneID" id="92358413"/>
    <dbReference type="KEGG" id="loi:92358413"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033853">
        <property type="term" value="F:aspartate-prephenate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033854">
        <property type="term" value="F:glutamate-prephenate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016212">
        <property type="term" value="F:kynurenine-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000033">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000021">
        <property type="entry name" value="Kynurenine--oxoglutarate transaminase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
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        <property type="entry name" value="Kynurenine-oxoglutarate_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
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        <property type="entry name" value="PLP-dependent transferases"/>
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    <proteinExistence type="inferred from homology"/>
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        <location>
            <begin position="31"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5469054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="414" mass="46314" checksum="466BEDB18B86019A" modified="2021-09-29" version="1">MSKIRAAQRLRGLSTKTIWEEMTPLANEHKAINLGQGFPTFAPAQLLLQELNKVVECSEQSPLAHQYCPPRGNAELVTQLCRSYAKLLCRDIEPANVVVTNGVTQALNAIFQAFIDDGDEVVLVEPFYDAYHQDIVVSGGVTKYVSLQPSTESAESWKLTREALLEVVSEKTKFILINTPQNIPGKVWSVEELEIIAEVVKQFDTVVISDEVYMHLTYGKPHVSIALLPDMWERTITLCSAGKTFSCTGWKIGWAVGCARLIGPIVQTVSYQTFCCSTPFQIAVARTIAKAEENGFYDTLRDEYAARVEQVSSMLESCGLSAVKPEGGFFVLADIAKVDPKHYYDALNKSHAKDWQFCMWLTKKIGVCAIPVTAFCKEESKPLYENYVRFACCRSQSELHAAAERLQELRQYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KAE0</accession>
    <name>A0A836KAE0_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_02572</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060151.1">
        <property type="nucleotide sequence ID" value="XM_067204599.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92358533"/>
    <dbReference type="KEGG" id="loi:92358533"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="346"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="445"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="557"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="731"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="868"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1176"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1306"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1403"/>
            <end position="1435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1447"/>
            <end position="1466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1495"/>
            <end position="1609"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1125"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="454"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1200"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1418"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1498"/>
            <end position="1517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1566"/>
            <end position="1609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5469174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1609" mass="167665" checksum="A8818453F605EAEC" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KD18</accession>
    <name>A0A836KD18_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3'(2'),5'-bisphosphate nucleotidase</fullName>
            <ecNumber evidence="2">3.1.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_03402</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">LSCM4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.7" evidence="2"/>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060961.1">
        <property type="nucleotide sequence ID" value="XM_067205409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KD18"/>
    <dbReference type="GeneID" id="92359343"/>
    <dbReference type="KEGG" id="loi:92359343"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008441">
        <property type="term" value="F:3'(2'),5'-bisphosphate nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050725">
        <property type="entry name" value="CysQ/Inositol_MonoPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43028">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43028:SF5">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032495192" description="3'(2'),5'-bisphosphate nucleotidase" evidence="4">
        <location>
            <begin position="20"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5471844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="432" mass="46212" checksum="F9BB279A89F20801" modified="2021-09-29" version="1">MTSVNVAQLLAVCVRASLAAQRYVMLSLVQLPEAEAKMTRAQCASSAYSQAHPRTVLDLTEADKAVLMDSLHQAVKIDVKPHRDHQDGDAADDLVTTADFLIQAVLMRALSESFPALPFTVTGEEDRPSVAVEEAAEACMAEHYRAIAAMPYEAELCAHVQAGDASGADAAVVLCADSDAVMRRRLGIFIDPIDGTSCFVGGFWQAPMTLVGITLDGIPIAGVMNRIFCYPLTGAGEPAETELQEKARVPGLSVVLNTPALTSPFVVFDGVLMPAPVRPEPQPECTRETALAVCRSSATKEAFLQRLLAELKPCSSVSARGAGYKQYHLLKKMLKGRHAPQEPITPADVFVCPPATIKKWDCCAPHAFLYALGSDIFDQDGTPLRYPLVGTCTGTAASSSEIAALTDGLVAVTPYAMREVARRLGWTLAPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KDQ7</accession>
    <name>A0A836KDQ7_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060357.1">
        <property type="nucleotide sequence ID" value="XM_067204805.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92358739"/>
    <dbReference type="KEGG" id="loi:92358739"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </evidence>
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    <sequence length="250" mass="25879" checksum="C9FA75C8EDC0462E" modified="2021-09-29" version="1">MATTPPGLLLTDEQRLALDQFEFYAIQERRGTPVLRVGSAMRSGSSSGSDSSSSSTASSSRRSSCATSPPSHFASAASSKAVVSDSALADRATHCDSTALCRGGNALPLTGARCEPLQRMCPERSRSIMDSQVPELEVPTPPSLHVIAAVPLLHDHDSAGKGDVASSAAGVSASSRRPRRGLRASAASGSAVPLEALVRHGDAGALDGAPQASVGERCEELAERLVRLSAQADAATFAMDRRVVPPLEFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5468920.1"/>
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        </location>
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        <location>
            <begin position="174"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5468920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="24498" checksum="EE331A7569CAB22D" modified="2021-09-29" version="1">MDEFRADDATQLEGNESNTALLQLQDAFVSALTASGTLGKIRAQLRATALALIRGDEDLQNAAVGPFIRPLSLTTPAKVSLLLLHDFLQHHHLQQTAGVLDVESGVHLLFHERSALLGDVAHLPGDGSLLERLVRSFENAGPRAGADPSRAPVVLSGPQLTSSCVVVEPPASPFSSSSSSAAGEQAAATAQPEDPDVEFELDKYEDSIAFSDAEGTIEAYMQCDEVELLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836KFN8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_02451</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067204480.1"/>
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    <dbReference type="GeneID" id="92358414"/>
    <dbReference type="KEGG" id="loi:92358414"/>
    <dbReference type="Proteomes" id="UP000674143">
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    </dbReference>
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        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15845">
        <property type="entry name" value="SNARE_syntaxin16"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF83">
        <property type="entry name" value="SYNTAXIN-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="203"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5469055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="275" mass="32280" checksum="00EF75AAB3C989B2" modified="2021-09-29" version="1">MEVKLRDRFIEFSERRAALRTRDGRFDSATQQELSEQLLIVPLWSRLPSDFEENALTLFRRIEQLRSMHLNFLKPKLRSKEEEDELRVVIDKQAAEIQTFLKMLEHAIIVGTQLKNTYSEEEVRVVKNVQMHLTLRLQDLALHFKSAQELFGTQLYRRERKSTKYMKIGSDAAYSAVQQEERTAHFLEMGFTEQDVQSLLIEEMQRDRTSKEIRDILGSIQEIHRMFEDLRTMVVDQGTMLDRIDYNVDKALASASKAQIELEKARDNSSGCIFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KFS6</accession>
    <name>A0A836KFS6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cell division cycle 45 (CDC45)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_02558</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC45 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060137.1">
        <property type="nucleotide sequence ID" value="XM_067204585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KFS6"/>
    <dbReference type="GeneID" id="92358519"/>
    <dbReference type="KEGG" id="loi:92358519"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902977">
        <property type="term" value="P:mitotic DNA replication preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003874">
        <property type="entry name" value="CDC45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10507">
        <property type="entry name" value="CDC45-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10507:SF0">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 45 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02724">
        <property type="entry name" value="CDC45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="160"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="160"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5469160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="810" mass="90111" checksum="D69B7CACCB203F40" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KG63</accession>
    <name>A0A836KG63_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_02206</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061277.1">
        <property type="nucleotide sequence ID" value="XM_067204240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KG63"/>
    <dbReference type="SMR" id="A0A836KG63"/>
    <dbReference type="GeneID" id="92358174"/>
    <dbReference type="KEGG" id="loi:92358174"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22648">
        <property type="entry name" value="Q4D6Q6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39665:SF1">
        <property type="entry name" value="PARAFLAGELLAR ROD COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39665">
        <property type="entry name" value="PARAFLAGELLAR ROD COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5472881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="115" mass="13028" checksum="C586B1CB8ED3D8DD" modified="2021-09-29" version="1">MPNLCVSCTFNPPIITLLGSTIREDTVRAMEAQIPLATSTAMNPSKDPPKFVFLSNPDHWRLEMFQHFCDELHKSSIFLVIIQSLEEEGWRLRASNSVAKKEGDGETTKLFFTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KGL0</accession>
    <name>A0A836KGL0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">9,11-endoperoxide prostaglandin H2 reductase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Prostaglandin F2-alpha synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">LSCM4_02705</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>prostaglandin F2alpha + NADP(+) = prostaglandin H2 + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45312"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57404"/>
            <dbReference type="ChEBI" id="CHEBI:57405"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; prostaglandin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060281.1">
        <property type="nucleotide sequence ID" value="XM_067204729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KGL0"/>
    <dbReference type="SMR" id="A0A836KGL0"/>
    <dbReference type="GeneID" id="92358663"/>
    <dbReference type="KEGG" id="loi:92358663"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000015">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0643">Prostaglandin biosynthesis</keyword>
    <keyword evidence="5" id="KW-0644">Prostaglandin metabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="19">
        <location>
            <begin position="19"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="16">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="18">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00067802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00079905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAG5470015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="280" mass="31799" checksum="7CEAA1B784AD415A" modified="2021-09-29" version="1">MVGKCTHVTLSNGVQVPQLGIGTWEAKDGDEVVLNVKWAISAGYRHIDTAHFYKNEGGVGKGISECGVSRSDIFVTTKLWNYDHGYDNAIAAFEQSRQALGVEYVDLYLIHWPGPNRSYIETWRAFEKLYEMKKVRAIGVSNFELHHLDDLLANCSVPPMVNQVEMHPLFQQKALRAYCREKNIAVTAWRPLGKGALLKEPQLMELAEKHKKSPAQVIIRWLIQLGVIAIPKSSHEERIKENFDVFDFELSPEDMGALESMDVNSRLGFHPDTFFPTERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KGX8</accession>
    <name>A0A836KGX8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Chaperone protein DNAj</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_03025</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060596.1">
        <property type="nucleotide sequence ID" value="XM_067205044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KGX8"/>
    <dbReference type="SMR" id="A0A836KGX8"/>
    <dbReference type="GeneID" id="92358978"/>
    <dbReference type="KEGG" id="loi:92358978"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000013">
        <property type="entry name" value="DnaJ subfamily B member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032632430" description="Chaperone protein DNAj" evidence="6">
        <location>
            <begin position="26"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="51"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="8">
        <location>
            <begin position="173"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="5">
        <location>
            <begin position="173"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5470330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="397" mass="44754" checksum="5E2DD7280CA59C44" modified="2021-09-29" version="1">MMRSRRAAMRCACALALLLTYVALSSRAFFSFGSGQRSEEQSEARHVPEVDYYKVLQLEGKREAATEKDIRQQFRRLSRLYHPDVAKTEEDKAKYSQVNRAYEVLSDKRKRKVYDMRGERGLRQLEERDRTKDTPGGGMNPLAQLFGMREDDGLRGADMELEAKVDLAKVFTGGQEVFKISKHKLCRACKGSGADATAAIAQCQRCGGSGVLRQRIRFAPGMIQEVHQKCPACGGEGRRPERVCSVCGGKRVVYGSSTVVLELEPGMAEDHVLKFEMEGEESPDRLPGDVIVHVHTLPHPVFTRRRNQLDLETSLTLTLKEALVGFDRNITHLDGVEQVRVQRRDTVSPYGTVVRLPGKGMPKLHVPSERGDLYVRLHYDMPGRLTEEQKKLVEKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KI56</accession>
    <name>A0A836KI56_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Amino acid permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_01644</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Polyamine:cation symporter (PHS) (TC 2.A.3.12) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059383.1">
        <property type="nucleotide sequence ID" value="XM_067203692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KI56"/>
    <dbReference type="SMR" id="A0A836KI56"/>
    <dbReference type="GeneID" id="92357626"/>
    <dbReference type="KEGG" id="loi:92357626"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015203">
        <property type="term" value="F:polyamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000041">
        <property type="entry name" value="Amino acid permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044566">
        <property type="entry name" value="RMV1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45826:SF7">
        <property type="entry name" value="ACID TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45826">
        <property type="entry name" value="POLYAMINE TRANSPORTER PUT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
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        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="249"/>
            <end position="270"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="290"/>
            <end position="323"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="447"/>
            <end position="469"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5466493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="524" mass="57267" checksum="FFF85142EF958A1E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KL97</accession>
    <name>A0A836KL97_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arf-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_03931</name>
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        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067205924.1"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="stromal membrane-associated protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Arf GTPase activating protein"/>
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    </dbReference>
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        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
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    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </evidence>
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        </source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5474755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="415" mass="43901" checksum="DF52DBDF10798400" modified="2021-09-29" version="1">MSAGSHNRHESKGQSGHASSADSNAGVYGGLSTGDPATSRYNSTAASTRGMHGAGLAPQQLQRFDALLRRPENRECFDCGTKQPRWASTNLGIFFCLRCAGVHRSMGTHVSKVKSTNMDSWVEPFMCVMEHIGNARGRLLYEYNMPPSARVTGMTDTAVLERTIRSKYERKLYYNPRFTELFAQFMETPIEGVSGGNAAAVAPPPEADAPSPKTDTPGEVQQQRAVLEELWGAPVSSPNTAPPFQEAVQGPTVSHTNVAELFSGAYPTPGANGNASAVGDGLGPPPAAQWNTVASLASVSPVSANNDLDWFAMQFGGPTSSLVDPARGGGHSGAPLENTLHPRSTSPTARSNTEDLFTGTNTSVSDRSKSGTKDEILSLFDSAPLAGAGGLTSSGARANTGRYPLAWQPQRVKPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KMG5</accession>
    <name>A0A836KMG5_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_05789</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
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            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063492.1">
        <property type="nucleotide sequence ID" value="XM_067207719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KMG5"/>
    <dbReference type="GeneID" id="92361653"/>
    <dbReference type="KEGG" id="loi:92361653"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5479781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="310" mass="34795" checksum="CC72DA3DBA0DD7BF" modified="2021-09-29" version="1">MLRLSKHRISLPFWVGGRLLSSTAILRVEPSSEERAREEELRRKVLQKYRGVQIPEATAHEYGHFSRMGINASAAQQAASNARAQGLSGFGGVPFQNRGGVDWLMLLTGCMLVYFSGKIFFRQFARGVNGLEMPLWTASVELQAKHLLFAVQFQQSEQEQLRKEFEAVRQINPFVNFFEWVRSRRPEFCSGRKYGTEYVMLTLVSYLCSSDGIRLGTVARTLQQSMTHKSTDSLQRVDDFIEQLQSAGFLFQGLRGVGSSSMHTPGYSPRLMYAPVSEAGQCLVQESDLTSALDVKSGEAHSSTPFSEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KMK2</accession>
    <name>A0A836KMK2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_05909</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
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            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063612.1">
        <property type="nucleotide sequence ID" value="XM_067207839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KMK2"/>
    <dbReference type="SMR" id="A0A836KMK2"/>
    <dbReference type="GeneID" id="92361773"/>
    <dbReference type="KEGG" id="loi:92361773"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14133">
        <property type="entry name" value="PKc_DYRK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF124">
        <property type="entry name" value="PROTEIN KINASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="192"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="42"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5479901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="499" mass="55897" checksum="5B40B2EF8F45A781" modified="2021-09-29" version="1">MPTSSGVDPTKLREVIRVLKSVGQVSIAESLEVEWGMRPHTISQGKNLKKTRKSLPQKSRESSKARGSSFPSLPSTNIAPSPLKVTSQRRFVVTCVGDEEDLWRPCADPADAKRCIAPLFDYGAGLQCDHYVEYAAHPVSFVPVQPYEKQQPPSNLPLRHFELKVFYELGKSGSEAKKEFEFVKGDRIGGRYRVDVPIDAATFSRTVRCHDEQTGQPVCLKIIRNSKSFLDQGFDELRALSRVNEAGDADEHCVVRLLDYFYFREHLVLVTELLLDNLYEHARKLDVVQRSSYFTLTRLQRIVRQVLTALKLIHSVGLIHCDIKPENIAFKSVAECDVKVLDLGSSCYVTDALSSYVQSRYYRAPEVILGCKYGPAVDIWSLGVTAAELATGTVLFNVESVPTMLASIASVCGPIPAEMLQEGRNTSLYVTVHGAFYDYEDERLMFHFPSEPPDAAVLFGFDDHDYVDFVRLCLTLDAALRPSAAQLLDHPFLTKTYTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KMK6</accession>
    <name>A0A836KMK6_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_05061</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062338.1">
        <property type="nucleotide sequence ID" value="XM_067207035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KMK6"/>
    <dbReference type="SMR" id="A0A836KMK6"/>
    <dbReference type="GeneID" id="92360969"/>
    <dbReference type="KEGG" id="loi:92360969"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5476105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="132" mass="14608" checksum="0947C54D25307F7B" modified="2021-09-29" version="1">MLRCGSRAVLRAPVFCRIIDVMRQHEPYARTGILYPIRVELGEGVESCTPAELQDKIDAILSRSQRFATVKTGNVYSRNNSVVTVIKAYGQYIVTGNMRGGYVKGDHRYGPRLTGYGGATAKPGLRWNGDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KMP9</accession>
    <name>A0A836KMP9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Flagellar attachment zone protein 1 conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_05204</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062458.1">
        <property type="nucleotide sequence ID" value="XM_067207155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KMP9"/>
    <dbReference type="GeneID" id="92361089"/>
    <dbReference type="KEGG" id="loi:92361089"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056614">
        <property type="entry name" value="FAZ1_cons"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23398">
        <property type="entry name" value="FAZ1_cons"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flagellar attachment zone protein 1 conserved" evidence="2">
        <location>
            <begin position="128"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5476225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="219" mass="24776" checksum="2A8CFD1FB897EA78" modified="2021-09-29" version="1">MSRRESCVWHPMPEEVRRSSVQSRRASLAAGRRKSLNANEPDWDVEAPPTPFHCDYSARENAAEAEHTPREAAAPPAESSKESQGAEEVSLAEVAPVTVVAESQSLDDEEAAAAQPSDALAEDSRVSRTRHTVRFHGEKWAKMLRKRRTEIEASFMEDIKDGASVMAHEAKRLKIKMHDCMEVTFVMYSDSRSRQREIHVALQNYSFPKTCQRYINFEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KNT0</accession>
    <name>A0A836KNT0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_04553</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">LSCM4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062746.1">
        <property type="nucleotide sequence ID" value="XM_067206537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KNT0"/>
    <dbReference type="SMR" id="A0A836KNT0"/>
    <dbReference type="GeneID" id="92360471"/>
    <dbReference type="KEGG" id="loi:92360471"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00106">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000196">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF15">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="5"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="493"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="554"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="928"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="318"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="401"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="562"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="626"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="949"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1001"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="77"/>
            <end position="84"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5477335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1028" mass="109618" checksum="991267D421503F99" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KP25</accession>
    <name>A0A836KP25_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Endoplasmic reticulum oxidoreductin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">LSCM4_05694</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">May function both as a monomer and a homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EROs family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000016">
        <property type="protein sequence ID" value="KAG5482434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="loi:92361560"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:FAD binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
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    </dbReference>
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        <property type="entry name" value="Ero1"/>
    </dbReference>
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        <property type="entry name" value="ERO1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613:SF0">
        <property type="entry name" value="ERO1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613">
        <property type="entry name" value="ERO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ERO1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ERO1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 17" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 19" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032323762" description="Endoplasmic reticulum oxidoreductin" evidence="19">
        <location>
            <begin position="25"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="16">
        <location>
            <position position="365"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
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        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
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        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
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        <location>
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        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
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        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
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        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="18">
        <location>
            <begin position="103"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="18">
        <location>
            <begin position="365"/>
            <end position="368"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008277"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011802"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAG5482434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="22">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="429" mass="48013" checksum="0A0BE47EC393D810" modified="2021-09-29" version="1">MNIEIGIKCIYTALLVLFLFFTHEAPKATTSSAAVLHNRTHPRIILNATKLDYGYCHSSPAEVDEGTESLLDVLNRITVSPYFRYFKVNSAKPCPYWAVSLLCTSAENTCNVCKCDENSIPEALRANEDMSELNTPDGSVTQSVLRPSNLDDWGDWLKADDGAEYVDLVSNPEGNTGYSGPLAAQVWRAIYAENCLSSDKDEACQEVSILKTLLSGLHMSINIHVCTSFYKDPELTSPQRNAGIYNNLNISFYPNCEMYNRRVAPFPDFVGNLYILYQFTLRALAKSKPSFTNDFNIFNTGARGEATLTDLELHENIKELFSSPLICYRTFDESAFLESEKGRALIPQFASVMLNVTRLMDCVTCEKCRIWGKLETKGIAVAMKVILNPKNEQITLDRSEMVTLVNLARQLAFSVRNAQRLGTVCKEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KP37</accession>
    <name>A0A836KP37_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061339.1">
        <property type="nucleotide sequence ID" value="XM_067204302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KP37"/>
    <dbReference type="GeneID" id="92358236"/>
    <dbReference type="KEGG" id="loi:92358236"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5472943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="166" mass="17245" checksum="200BD7F1513716A5" modified="2021-09-29" version="1">MSTLRISASLAPQAQASNYPTAHNISFRSSPLSTPSTRRNTKLKCPSCGVWGEKGTVCKVCRSAIPGPRPIYALPSSGTSKRPTTGSACRFAVLPSSTQTMVAASSGTASRRDRLIKHEAPQATAAALHLRACRSRASAPPLTATQPTSGTPLSAPAKEQSSSLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KP73</accession>
    <name>A0A836KP73_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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                <person name="Bates M.D."/>
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        </source>
    </evidence>
    <sequence length="391" mass="42139" checksum="8746DE897942599A" modified="2021-09-29" version="1">MFTTEDPQDIIVLKTAAFRHATRRIRHAMLASAADAASPPRATPCQDRKEEIRGAHNTGSGREPFMGLTTRSVPCFTFKLPIRSAAGSDAGTGGGGITAPHALAARAALQEALQKHEDVLRAWADEPVQHISSGTLEAIAFHSKPAALLSSAAQPRHGLAEQQQQMRTEAVHMGCQPSADNAVAHVAALAQPYCRVFAQGSMARIGVPPEVVPKRTAAQAATPGIMIAARPDATRGEASSTPLESSRGNRSVTSTFSSSCAPQPLHSPERFVPLSHSAGLPPWTANDSRSSTPLSPYQLPLRMRPAPVATSRSSPPADFHRRAFLDEQAQRYSQWRNRQAAVLHKLAPDMWGRALPHYAALDRQPRVMDSGLNTHASHVRRSRYDNGVVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KTQ0</accession>
    <name>A0A836KTQ0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gamma carbonic dehydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000011">
        <property type="protein sequence ID" value="KAG5485302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065039.1">
        <property type="nucleotide sequence ID" value="XM_067207865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KTQ0"/>
    <dbReference type="SMR" id="A0A836KTQ0"/>
    <dbReference type="GeneID" id="92361799"/>
    <dbReference type="KEGG" id="loi:92361799"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04645">
        <property type="entry name" value="LbH_gamma_CA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047324">
        <property type="entry name" value="LbH_gamma_CA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050484">
        <property type="entry name" value="Transf_Hexapept/Carb_Anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13061">
        <property type="entry name" value="DYNACTIN SUBUNIT P25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13061:SF29">
        <property type="entry name" value="GAMMA CARBONIC ANHYDRASE-LIKE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5485302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="34206" checksum="5645CA0708CECA47" modified="2021-09-29" version="1">MFRSCFLRCAPNASAKVPEQLPEWAIKKRTYLSLALDRWALKLQRFATKLIRFSDRMMGVQPKEELYRIPRLLKVSGKRPTVMDNCFIAPSALVTGDVHVGRKNYIGYNAIIRAEEGESIHLGESCNVQEKAVVTGNTTIGKWTTIEPMAIVESADIASCSFVGANAIVMKGSSIESGAMLCAASVLQAGAVIPSGEMWAGNPAQKVADLTEKEKDDIVKAAKHAVLLAIEHHDSWELTWEEIEDQREAREQFARYAEGNRELRIKAMYIKEPPRPNRKKMGRRTPHELVDGSENAPALTESIHQGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KVR5</accession>
    <name>A0A836KVR5_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_05911</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063614.1">
        <property type="nucleotide sequence ID" value="XM_067207841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KVR5"/>
    <dbReference type="SMR" id="A0A836KVR5"/>
    <dbReference type="GeneID" id="92361775"/>
    <dbReference type="KEGG" id="loi:92361775"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5479903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="443" mass="48250" checksum="2800AEF45D14C09E" modified="2021-09-29" version="1">MNADYIRQLAIDVSSDNIAVSRDATKRLQQLLTPPQIVAMLKDAPTTHALCALLGEMEVVGNVDVFHLIGRVLEVVLTQPSRENMTVLFAPAAQFLVEFIVRSVAAADTAIAGSMSKALYLLIAIAGDNAQAAAFLGPCLDAKFHSEKVLRLFDCDAVESLENKRVCCFLEQWTSLLPFMFDATQSSFENDPLLQANYIVASGVACRTVAVPAVLRQRTMDILRANHDNLCFAYVCRFWSIVLLRHEANGQRDAAACVSCVMPAVEGAERDETATEAIFDLLGSAASTKAGWDAVTGYLPCKTLQVRLSSTSSSLRLSTLNLMSSMLASPHMNASFFTKELLLDAWQTRTSPDDMVRLVLWRVANAVLRQEGLNQILCAVCASFLSSGAHEENVAIRSLKLAATECLLRHSTLPENVKTRLSQVIERGLYPAGSSGVSLMTKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KWU9</accession>
    <name>A0A836KWU9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_06540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000019">
        <property type="protein sequence ID" value="KAG5480968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063969.1">
        <property type="nucleotide sequence ID" value="XM_067208457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KWU9"/>
    <dbReference type="SMR" id="A0A836KWU9"/>
    <dbReference type="GeneID" id="92362391"/>
    <dbReference type="KEGG" id="loi:92362391"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18316">
        <property type="entry name" value="BTB_POZ_KCTD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499">
        <property type="entry name" value="POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499:SF131">
        <property type="entry name" value="VOLTAGE-GATED CHANNEL, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="140"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5480968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="445" mass="49709" checksum="B2E32E32892C8E26" modified="2021-09-29" version="1">MGVGCWGTSVPIFVLGAVERHLRTTAPHSPTIARVVRPSPHHAFFSWHRCVYACLSVFLCPLVTPRPSCTGGSDVPRASRTVLHVLCSSASPFSFLSNTSFSANRNRCCTWPHVCPTPTQCELEERAHVHWAHKRKQMNRVVKVNVGGRYFQTRLSTLLRFPDTSFAKMFEGLAATSVSPPTPSPPQETAEREDVFVDANPDVFEKVLGFLRTNHIQLPVNDEGLRAELVHHLNTWDLMPHAFPAPAADGDAESEGAHLVELPDVCVVQLCDHMQHDQGVKRHAMTITYGADGFQLRKLTQMIRRDLNQQLSSTYWQCYQTNERAAFFATTKVANGAADILTTSITQQVVQHTERLGYHLAASYVTLSPDVVHTSVRMFIHNFIFRRVRLPALEAADEAAVLGEEEDGVETYQNFEPRPVGPQKVQWADSPSRPPAQDVSSDLWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FLJ5</accession>
    <name>A0A836FLJ5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Exosome complex exonuclease RRP41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_00322</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058508.1">
        <property type="nucleotide sequence ID" value="XM_067202407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836FLJ5"/>
    <dbReference type="SMR" id="A0A836FLJ5"/>
    <dbReference type="GeneID" id="92356341"/>
    <dbReference type="KEGG" id="loi:92356341"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000047">
        <property type="entry name" value="Exosome complex exonuclease RRP41A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF0">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="2">
        <location>
            <begin position="22"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="3">
        <location>
            <begin position="155"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5464877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="246" mass="27050" checksum="F5B0B055C00208FE" modified="2021-09-29" version="1">MSRQKEYVSPAGLRLDGRRPLEARRMDIVFDTLSACDGSCDITVGQSRVCASVFGPRESLHKQEAKHDKVLVTCEVAVAAFAGENRRNPQRRSKLSEDIGAAVVQVARSVILLSQYPNSQIHIYIEVLQKDGNEKTACINAACLALIDANVSMRDAVCCIDVGFLDEHMLVDLTSEELRSQCPVIAAAFTGHDTQNIIWLETTSRLPPELAARLLKCAEQGAAELFETTMRKALEEHAKKILSLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FLK4</accession>
    <name>A0A836FLK4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arf-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_00338</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058523.1">
        <property type="nucleotide sequence ID" value="XM_067202422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836FLK4"/>
    <dbReference type="SMR" id="A0A836FLK4"/>
    <dbReference type="GeneID" id="92356356"/>
    <dbReference type="KEGG" id="loi:92356356"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08838">
        <property type="entry name" value="ArfGap_AGFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044820">
        <property type="entry name" value="AGD14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46085:SF3">
        <property type="entry name" value="ARF GTPASE ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46085">
        <property type="entry name" value="ARFGAP/RECO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="3">
        <location>
            <begin position="9"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="127"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="405"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="166"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="183"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="405"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5464892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="448" mass="47928" checksum="6B90F4F98F4EC930" modified="2021-09-29" version="1">MNIRQRKSERHKDMLRKLSQNGGNKSCFDCGMRGPLYVVSDFGIFVCSGCSAVHRSFQHKVKGITMSEFTDEEIARLSASGNDRARTVWLSAFHDQLPCSGDVVALKDHVRIVFEERQYWDAQEFSALEKSRERPSEQSLQVLPPRAESTPAVSSLSPAPEAHTALSRSVSAVATSAQTDWAAPPPLTSAPTPPTRPPRDDVFDSLFAGPAQSPQMPHSAAPPSPSPPMAASRAPAPPAPQQPATVSSIVDDLFAGVPSPAVQPAGGHGVFYPHQQQQPMGFHTGGTVYNFTQGPPSNMTAPPPLQSLNPPCQKLLQQQSMPYTAGNPTGYTPFVGNQQASKLEFAAPPTPAENANQYQQQQQQTFTWGQPVPTQLHQPPQGIMGMFGTAGPAAPYSVPAQSQGYSFNSGAPSTNAYPSARGVAPQAHQTPPFTSNPPPQQEGWGAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FVV0</accession>
    <name>A0A836FVV0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Phosphatidate cytidylyltransferase</fullName>
            <ecNumber evidence="13">2.7.7.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LSCM4_02972</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.7.7.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="13">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the CDS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="13"/>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060543.1">
        <property type="nucleotide sequence ID" value="XM_067204991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836FVV0"/>
    <dbReference type="GeneID" id="92358925"/>
    <dbReference type="KEGG" id="loi:92358925"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000374">
        <property type="entry name" value="PC_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46382">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46382:SF1">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01148">
        <property type="entry name" value="CTP_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01315">
        <property type="entry name" value="CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG5470277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="498" mass="53805" checksum="62CEF762C7727163" modified="2021-09-29" version="1">MTGDGMATDLPANASPARNRIGLTNIQMRTVTICIVGPAVIAFANYSERCATALVFFATFVCGIEWSGVKRHLKVALIMSMDNAATSTSRSPMPSPTQLLDFVARPLPSSPYIEGVPLCPEEYALPVAPISLYSILKHLGWALLAVAAHMGEEVFLVVLELYFLIFVVVTLAAHNQLKLKVEHAMRRLSQELSSGSQSNLQGVDDSAGNDGCAPAATAALNAELGLSLKDEGMTKEARVAKAQRDYFLLMELRMIAERQPTEQFLDFCLDIFGILWITGIITPIFVYRIANVGVPWLGSTLIGNFANDIAALVVGRSLKVLRERYGQIYDVTGEEAPATPTARQPRKRPLKEASGFVRAVLRSPHHLYPAISPNKSVEGAVAGVVMNAVSFAGLMLLSYRGLFAAPAANIVNPAFQSVALWLLLGVIMGVLGVCGDLLQSMLKRAARVKDAGFIIPGHGGMLDRVDGMLLVFPFVHCALRVITRLSSDSRNSFSFFAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G302</accession>
    <name>A0A836G302_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_00693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058870.1">
        <property type="nucleotide sequence ID" value="XM_067202769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G302"/>
    <dbReference type="GeneID" id="92356703"/>
    <dbReference type="KEGG" id="loi:92356703"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5465239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="646" mass="71081" checksum="0A08E2F392C82B92" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G5V2</accession>
    <name>A0A836G5V2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA-directed RNA polymerase III subunit RPC3</fullName>
            <shortName evidence="5">RNA polymerase III subunit C3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_04337</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eukaryotic RPC3/POLR3C RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062260.1">
        <property type="nucleotide sequence ID" value="XM_067206323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G5V2"/>
    <dbReference type="SMR" id="A0A836G5V2"/>
    <dbReference type="GeneID" id="92360257"/>
    <dbReference type="KEGG" id="loi:92360257"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000705">
        <property type="entry name" value="Hypothetical_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055207">
        <property type="entry name" value="POLR3C_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039748">
        <property type="entry name" value="RPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12949:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12949">
        <property type="entry name" value="RNA POLYMERASE III DNA DIRECTED -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22536">
        <property type="entry name" value="WHD_POLR3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase III subunit RPC3 winged-helix" evidence="6">
        <location>
            <begin position="422"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5475752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="604" mass="65499" checksum="89C776494D19FE0C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G6Q5</accession>
    <name>A0A836G6Q5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S ribosomal protein L35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_05241</name>
        <name evidence="5" type="ORF">LSCM4_05242</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">LSCM4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062494.1">
        <property type="nucleotide sequence ID" value="XM_067207191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G6Q5"/>
    <dbReference type="SMR" id="A0A836G6Q5"/>
    <dbReference type="GeneID" id="92361125"/>
    <dbReference type="KEGG" id="loi:92361125"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00427">
        <property type="entry name" value="Ribosomal_L29_HIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.310:FF:000002">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3450:FF:000001">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_uL29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_uL29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045059">
        <property type="entry name" value="Ribosomal_uL29_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_uL29_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL29-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="Ribosomal protein L29 (L29p)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5476261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5476262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="127" mass="15178" checksum="8B912734757EDDBF" modified="2021-09-29" version="1">MSHHMKIKDLREKSKDDLLKTLTEYKKELSQLRVVQQTGGAETRLGRIRPIRKSIARILTVLNQNERSNLKKFYSDSKMRNKTPKVLRAKLTHRRRLALKDNEKNRKTSRQMRQAHRFPKRVYAVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G6U9</accession>
    <name>A0A836G6U9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_02569</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060148.1">
        <property type="nucleotide sequence ID" value="XM_067204596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G6U9"/>
    <dbReference type="GeneID" id="92358530"/>
    <dbReference type="KEGG" id="loi:92358530"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="131"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="182"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="277"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="297"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="318"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5469171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="334" mass="34788" checksum="73F11920A5694E65" modified="2021-09-29" version="1">MVSAVKSSHPSSTHDCSARISALGRSTTPTATIATLDSGDAAACSPSGHARRSLLCPTPSAATTSGAGSVGSAVVDSAKQSSKAGVASALLPSGAGGFPVAGANSGAVDAALSHSTGETFGGVGSATKRYCSHCKVAGEVLYLCPCGLARYCGTACQRAQWPFHKAICGHAVRAIRPPMRRCDWCRTSSQTLRQCGCGYAYYCDTLCRRTDWTHHCAVCSMVASQALTTTLAGPRALRARREVATQTAHWQICAPVIHPTRRRDCSTVADNAAGARFRRHTSRRGQHLQPGSDGEDSAFSASSSRSSLEAAADATVTPKMSSRYRSCSRALSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G9K9</accession>
    <name>A0A836G9K9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TPR protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5468024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059826.1">
        <property type="nucleotide sequence ID" value="XM_067203176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G9K9"/>
    <dbReference type="SMR" id="A0A836G9K9"/>
    <dbReference type="GeneID" id="92357110"/>
    <dbReference type="KEGG" id="loi:92357110"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052769">
        <property type="entry name" value="TPR_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46014">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46014:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5468024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="31433" checksum="E00111B3ADBCE2FF" modified="2021-09-29" version="1">MPAIVTQMPSSDDDNGQQPLSPTQHAQLAGDGKVEDAVLDAASDAEAGAEEESNSLQREAEHSSAERVVDVEECARLKAAGNELFKDGDISEALTLYRKALWCAPIKPVPPRPTATRTPSASPKPSDGSVAAAGEGTAAECDEVEAEKQPMDTTDYTLTAQVYCNAGFCLMKLDVKEEAVHMLSEAIRHDESYMKAYIRRADCYYSMQKWSSAYGDYESYEKLGGALDAQGRSRKANSKAKVDEEMQKMLGELKNLGNKILGNFGLSTDNFKFDKDPNTGGYSMRFER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GDQ9</accession>
    <name>A0A836GDQ9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">KOW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_02954</name>
        <name evidence="6" type="ORF">LSCM4_02956</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">LSCM4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060525.1">
        <property type="nucleotide sequence ID" value="XM_067204973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GDQ9"/>
    <dbReference type="SMR" id="A0A836GDQ9"/>
    <dbReference type="GeneID" id="92358907"/>
    <dbReference type="KEGG" id="loi:92358907"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06090">
        <property type="entry name" value="KOW_RPL27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.770:FF:000002">
        <property type="entry name" value="60S ribosomal protein L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001141">
        <property type="entry name" value="Ribosomal_eL27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041991">
        <property type="entry name" value="Ribosomal_eL27_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038655">
        <property type="entry name" value="Ribosomal_eL27_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10497">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01777">
        <property type="entry name" value="Ribosomal_L27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="4">
        <location>
            <begin position="4"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5470259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5470261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="134" mass="15318" checksum="6AC37DCA60B0F8B7" modified="2021-09-29" version="1">MTKFLKPGKVVIVTAGRYAGHKAVIVQNSDVATKERPYGRALLAGIKKYPKKVVRGMSKQTIARRSQVGVFLRVVNHKHFLPTRYNVDMSKELRGKINVSDASRRSRSKKLVKHVFQARYNAGSSAWFFQRLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GE56</accession>
    <name>A0A836GE56_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_03397</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060956.1">
        <property type="nucleotide sequence ID" value="XM_067205404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GE56"/>
    <dbReference type="GeneID" id="92359338"/>
    <dbReference type="KEGG" id="loi:92359338"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5471839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="149" mass="16596" checksum="1277FD56793D41F3" modified="2021-09-29" version="1">MGRKKRVSDVETAPELSFVQGGALNMIILKGAEGIQQVAVDTAAFLEDKRVVRSAHMDAVTFSQNVIFKVTLDFVEAMACIPETAVRETTDWMLLSCAGAHAYYSTVDQRLVLQQCKTSLQSSIPELEFPISVVLRFDSDQWVVERVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GE96</accession>
    <name>A0A836GE96_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_03449</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061389.1">
        <property type="nucleotide sequence ID" value="XM_067205452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GE96"/>
    <dbReference type="SMR" id="A0A836GE96"/>
    <dbReference type="GeneID" id="92359386"/>
    <dbReference type="KEGG" id="loi:92359386"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15840">
        <property type="entry name" value="SNARE_Qa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000096">
        <property type="entry name" value="QA-SNARE protein putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF38">
        <property type="entry name" value="LD27581P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="4">
        <location>
            <begin position="158"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="189"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5473386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="251" mass="29114" checksum="FF9BC6110A907E9F" modified="2021-09-29" version="1">MVDPSWRRACDLLAKHLQSLGQKTTTIRRITNRRTSVEEIKKEREEVKRITHDANETDVQDIRKVVKSLERFILLDKGLSDEGRKLAKDAEVVLQDYERTCNDFYRKCMEGESARGGHASRAHRAFCDASEDDGDNERQSLLSMEAPQRVQFERDLYEELMRERQRETGEIAENVRDIHEIFQHINGMVNEQGEQLEIVENNLSAAERATRNASQHLRRAQQYQTTSSRNKILFICMVIVLVIVCIGLLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GEW0</accession>
    <name>A0A836GEW0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PSP1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_01269</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059017.1">
        <property type="nucleotide sequence ID" value="XM_067203326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GEW0"/>
    <dbReference type="GeneID" id="92357260"/>
    <dbReference type="KEGG" id="loi:92357260"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047767">
        <property type="entry name" value="PSP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007557">
        <property type="entry name" value="PSP1_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041131">
        <property type="entry name" value="RicT_YaaT_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830">
        <property type="entry name" value="PROTEIN PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830:SF16">
        <property type="entry name" value="PSP1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04468">
        <property type="entry name" value="PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51411">
        <property type="entry name" value="PSP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP1 C-terminal" evidence="2">
        <location>
            <begin position="284"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5466127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="411" mass="45225" checksum="52E146DD4B99A54C" modified="2021-09-29" version="1">MAYTENRASKAIDVFLDNRSGSPPAVTSANNTISNNAMDHNRFATMIALQNRLLSIMAEAQTIVQHLQQNGFFPRGSGANPEEDAANIIMQMLRASLEASSSSNSPPSGMGCGSPSAIDAGSAQRVPSPNSNIPASLDSVPSWAPTKSSQDSNTHNRSNANNVIHRAVSHNAVEEFLLSGQGGQPQQQQQHNSNGADETHNEEGDELPEGSEMLAFVEFKRGRVRKYVCDHRIEPGNYVLVDGDRGTDCGLLVQTIERKPNNETAVVSMEGCDIRDDKIKLENGRVLRQASEEDIDRLHNIIANAESVALKTCRQRCLELGIDIDLQDVEYQFDMKKISFFFDCDHSVDFRSLVRELYRTFGARIWMENINPKVKNSMPDASGHERGHGGGHHGNGGGWRNNHRGGRGRDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GFD2</accession>
    <name>A0A836GFD2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_01608</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
            <location evidence="1">Flagellum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ropporin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059347.1">
        <property type="nucleotide sequence ID" value="XM_067203656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GFD2"/>
    <dbReference type="GeneID" id="92357590"/>
    <dbReference type="KEGG" id="loi:92357590"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003117">
        <property type="entry name" value="cAMP_dep_PK_reg_su_I/II_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14952:SF19">
        <property type="entry name" value="RIIA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14952">
        <property type="entry name" value="ROPPORIN-1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02197">
        <property type="entry name" value="RIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00394">
        <property type="entry name" value="RIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47391">
        <property type="entry name" value="Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="189"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5466457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="279" mass="32061" checksum="93ADABA0973AA80E" modified="2021-09-29" version="1">MSTETFRERTLATQYQPRQHLPPNFSNVLKEYAREVLRHQPSDILEWSAAYFRKLALETDPLQAKQPPPDHYTPLVEDPERAMLANKMVKVFSTMDLSGSGRLQVSEVRRVLMEAFELTESQVLYLLTAPFTTIIEDCGSGMTGDVIEYSPFSHAAVRTIQYFQQHQSFSFDVDPIDSGTTVHGMNRYDVEQGFLRIFRLLDEAGTGRLLLQDYQGALENAPYHLTRRDIRVLRLECGTCGGEEDGAPREMEYEKELPHMFERLLLAEAFNLFEEEVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GGN6</accession>
    <name>A0A836GGN6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA intron endonuclease catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_00403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058586.1">
        <property type="nucleotide sequence ID" value="XM_067202485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GGN6"/>
    <dbReference type="GeneID" id="92356419"/>
    <dbReference type="KEGG" id="loi:92356419"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA intron endonuclease catalytic" evidence="1">
        <location>
            <begin position="88"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5464955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="192" mass="21263" checksum="50B0B6C1D2143337" modified="2021-09-29" version="1">MHHTPDTPKEAMLVIDGTNGPLFRVAESAAAMAYLSTHYPQCKKRGVGWQLSVEEVSLLQSQLQRSDGVRFASAETEEQFEVLRARHARDCVVYAALTTDHGYKLRHGSQFGANYIGYQDVGMHGECLLFTGPLAELEQVRAVRIARSVGKRAMLVLVQEGDNGHPSTVTVTDLVADCFAHAECPHKSRRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GGP6</accession>
    <name>A0A836GGP6_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060921.1">
        <property type="nucleotide sequence ID" value="XM_067205369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GGP6"/>
    <dbReference type="GeneID" id="92359303"/>
    <dbReference type="KEGG" id="loi:92359303"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5471804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="202" mass="23416" checksum="15BDCE9F13261A6C" modified="2021-09-29" version="1">MEEFDVYKRGTLKASKWTKRVLSLHSHLGIAAITRHNSPQDRFYRCMRVSSVHIWPQYNQKHVKENFDSMEVKLTVRVKGIPAKIRVREARSATGPVKVYHYTMKGPEAVKHTWMLRFRSYEDFEEAMRLFQAMKVSDQHSSLATSAETRRPAQGGEETTAEDEIDALLQRSMIPGDLNQGLEPIRAHWQQTRLKKDECATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GH29</accession>
    <name>A0A836GH29_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_00679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058856.1">
        <property type="nucleotide sequence ID" value="XM_067202755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GH29"/>
    <dbReference type="SMR" id="A0A836GH29"/>
    <dbReference type="GeneID" id="92356689"/>
    <dbReference type="KEGG" id="loi:92356689"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CAF1_poly(A)_ribonucleases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15092">
        <property type="entry name" value="POLY A -SPECIFIC RIBONUCLEASE/TARGET OF EGR1, MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15092:SF22">
        <property type="entry name" value="POLY(A)-SPECIFIC RIBONUCLEASE PNLDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5465225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="511" mass="58548" checksum="AAC6EE0956BFD384" modified="2021-09-29" version="1">MDITRFNQLVALPDFAREVQRCEFCAIDQEMTGVDAPGASALFGAPPEAVYHAKRAAVETYNAFQMGIALFTKAQNNTYEVRPYNFYLLNCSGDLRLSLSAISFLAANHMNFQTWLTSGLPFCNQEQEYVYEEKRQAPFSDEVEKNTADAMIEVIDEWLSSGSGQLVNEVSCSIDFARRFQAFISRRYDSHITASYDGKPYLAQKIKFTFTKLDTNDWAIEREKSRLQSERDKARQLGFRQFWKVLLQSGKPIVGHNFMHDAMFMIHMHETTLPVNYIEFKRILQRKLPVIYDTKTMAAKLTGDDAFQVTHLETLYQECRRRAGLSSEEFTQQYQLPSGFYSYNDYAVKVQSKAHEAAYDAYMTGIVFLLMHRLYPNAFIGLKNIISAFGSAYFFCVDTEDQLVNPDTFVLRCTIPCYTEEIESLFFSTEKSSAQATENGKVDIRKLSYQVSALETSEDTKKCTSFCVRMKQSTGLDDLRRRLQSIREKDLSSGTNVNLLLLDSITVHKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GI66</accession>
    <name>A0A836GI66_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_04098</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062024.1">
        <property type="nucleotide sequence ID" value="XM_067206087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GI66"/>
    <dbReference type="SMR" id="A0A836GI66"/>
    <dbReference type="GeneID" id="92360021"/>
    <dbReference type="KEGG" id="loi:92360021"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5475516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="187" mass="21574" checksum="1FE0563258EDD33D" modified="2021-09-29" version="1">MSSGALGRGSFHSVVAGANPNRIPTYYNAAYELIQLHRAHRDVTRNFLVRDKVFDNKFPGCSLANGLFKMVPNKRDNFHTRELTESIRHRTIWAQRIQQQRAINTAILEDAKKELSPAQLEDRFSYRTPDAAAYFSPQEYTAANNWPNYWQHPTEKHVVPRPRWRREPELGGITRVRDAVATPVADF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GJE1</accession>
    <name>A0A836GJE1_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_00391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058574.1">
        <property type="nucleotide sequence ID" value="XM_067202473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GJE1"/>
    <dbReference type="SMR" id="A0A836GJE1"/>
    <dbReference type="GeneID" id="92356407"/>
    <dbReference type="KEGG" id="loi:92356407"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="58"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5464943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="121" mass="13569" checksum="AC1A0A6389376023" modified="2021-09-29" version="1">MALVISDEAAREAKRILACRNSFEVLELSPSNCTKEMVLEHYETKASLFKGLFRSKLAMEAKARLGNAKVRLADAQLREKEAASLKELQRDAHKDYAELQALEARTRILEMRAATVQYGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GJF0</accession>
    <name>A0A836GJF0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphoglycan beta 1,3 galactosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_03442</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061382.1">
        <property type="nucleotide sequence ID" value="XM_067205445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GJF0"/>
    <dbReference type="GeneID" id="92359379"/>
    <dbReference type="KEGG" id="loi:92359379"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF351">
        <property type="entry name" value="BETA-1,3-GALACTOSYLTRANSFERASE PVG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5473379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="807" mass="88189" checksum="A27C74DD304E7010" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GJH7</accession>
    <name>A0A836GJH7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_05216</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062469.1">
        <property type="nucleotide sequence ID" value="XM_067207166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GJH7"/>
    <dbReference type="SMR" id="A0A836GJH7"/>
    <dbReference type="GeneID" id="92361100"/>
    <dbReference type="KEGG" id="loi:92361100"/>
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</entry>
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                <person name="Urbaniak M.D."/>
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                <person name="Al-Salem W.S."/>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
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                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
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            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061850.1">
        <property type="nucleotide sequence ID" value="XM_067205913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GLQ6"/>
    <dbReference type="GeneID" id="92359847"/>
    <dbReference type="KEGG" id="loi:92359847"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5474744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="795" mass="85694" checksum="1DCEC02F831305E2" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GMK4</accession>
    <name>A0A836GMK4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.57</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_05293</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Displays methyltransferase, positive regulation of the poly(A) polymerase and transcription elongation activities. Involved in the modification of both mRNA ends and in intermediate and late gene positive transcription elongation. At the mRNAs 5' end, methylates the ribose 2' OH group of the first transcribed nucleotide, thereby producing a 2'-O-methylpurine cap. At the 3' end, functions as a processivity factor which stimulates the activity of the viral poly(A) polymerase OPG063 that creates mRNA's poly(A) tail. In the presence of OPG102, OPG063 does not dissociate from the RNA allowing tail elongation to around 250 adenylates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with poly(A) polymerase catalytic subunit OPG063. Interacts with OPG109 and OPG123; these interactions might help linking transcription to capping and polyadenylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Virion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.57" evidence="2"/>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5477901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062808.1">
        <property type="nucleotide sequence ID" value="XM_067207240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GMK4"/>
    <dbReference type="SMR" id="A0A836GMK4"/>
    <dbReference type="GeneID" id="92361174"/>
    <dbReference type="KEGG" id="loi:92361174"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004483">
        <property type="term" value="F:methyltransferase cap1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20760">
        <property type="entry name" value="capping_2-OMTase_Mimiviridae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000744">
        <property type="entry name" value="Poly A polymerase regulatory subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000176">
        <property type="entry name" value="mRNA_MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025804">
        <property type="entry name" value="Pox/kineto_cap_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01358">
        <property type="entry name" value="PARP_regulatory"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51612">
        <property type="entry name" value="SAM_MT_2O_PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5477901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="438" mass="50281" checksum="B054461745DBC746" modified="2021-09-29" version="1">MLFDQRRVLTEDAPRRPYQNNASTASFEHRLLKGLHYGQRKLILSEIEFFLQIAMYTERRGSTASPKKVLIVYAGAACGFHLPFLFSLFPTLEFVLIDPAPMCPRVKAIASEEESCVLELIEDICTPELCLRIRRTYFETHDIFLVSDIRSGHPTGMSLNQEHTDMIVQDNNAQREWCFSLEVEAAMLKFHPPYPATKDSNSGQDNAEDTTMEEYMYLDGTQLLGVWAPKSSSEVRLVVVGPFKRGYEPPTRRYYCTAHEEQCYAYNMDKRYDKDCAAERLILESYLSAFPGVYESVEQLSKTLSEKLEYPLFCPLEPGFTEQHARWVTLLYSTKKPSALQYFGILKNDMSVDQVAGLVTKYKDCKEIPTDVKVGSIELTSHFWSVFAAGDFAAVYCFPLVRWGWKQHSYRRQSNNQQCYGNQSRRRCAGRKRTSTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GNR5</accession>
    <name>A0A836GNR5_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_04749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000023">
        <property type="protein sequence ID" value="KAG5478516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063177.1">
        <property type="nucleotide sequence ID" value="XM_067206730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GNR5"/>
    <dbReference type="GeneID" id="92360664"/>
    <dbReference type="KEGG" id="loi:92360664"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5478516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="692" mass="72499" checksum="C8A13EA58E85D014" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GPZ6</accession>
    <name>A0A836GPZ6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Zinc transporter-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LSCM4_03351</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">LSCM4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060914.1">
        <property type="nucleotide sequence ID" value="XM_067205362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GPZ6"/>
    <dbReference type="SMR" id="A0A836GPZ6"/>
    <dbReference type="GeneID" id="92359296"/>
    <dbReference type="KEGG" id="loi:92359296"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050681">
        <property type="entry name" value="CDF/SLC30A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11562">
        <property type="entry name" value="CATION EFFLUX PROTEIN/ ZINC TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11562:SF17">
        <property type="entry name" value="RE54080P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0864">Zinc transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="58"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="11">
        <location>
            <begin position="62"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="12">
        <location>
            <begin position="357"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="218"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG5471797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="453" mass="48536" checksum="171666573FD5C405" modified="2021-09-29" version="1">MSSEEAGETTGLTESTSGPAAANYHAASNAVHVTLVEERTIDQALSAVEARRHAEKKVLMGALIFCFVFMLVEFAGGVIAHSLALLTDAIHLLTDVGSYGLSILALVAAGRAACFRYNYGWHRAEVIGTLISVFSIWALVTWIVIEAGYRTYDTYMCSRVPAQISAGAAKVRNCEAVDSRLMVVVGVLGMAVNVVCASILYFGGSHGHSHFGGSHGHSHGEGEEHNHVHDHGYSHVHDHGVAHEHGENDELEHHHDYGHDHEGGTQSGGGIGNNMGFAVHAAILHAMGDCVQSIGVIFAGIFIYFCNYAYYGKHTYEHSLFNLADPFCSVVFAFITLNMTKSLLKDLLGILMESTPASVDYRALEAALRQIDGVVSVHDLHVWSLSADYVSLSVHLVADDSVGALHKAQQICKVRFGIGHTTIQVDPVAVGTASCASACASPTLQNEMRSLGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GQ64</accession>
    <name>A0A836GQ64_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dynein arm light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_05370</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the inner dynein arm light chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5477974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062881.1">
        <property type="nucleotide sequence ID" value="XM_067207313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GQ64"/>
    <dbReference type="SMR" id="A0A836GQ64"/>
    <dbReference type="GeneID" id="92361247"/>
    <dbReference type="KEGG" id="loi:92361247"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019347">
        <property type="entry name" value="Axonemal_dynein_light_chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13183:SF0">
        <property type="entry name" value="AXONEMAL DYNEIN LIGHT INTERMEDIATE POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13183">
        <property type="entry name" value="AXONEMAL INNER ARM DYNEIN LIGHT CHAIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10211">
        <property type="entry name" value="Ax_dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0243">Dynein</keyword>
    <keyword evidence="3" id="KW-0505">Motor protein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="157"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5477974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="237" mass="27345" checksum="ABAEA5A00E1681B4" modified="2021-09-29" version="1">MSATAPASLVKYETPVLLSEALHKKSLTAKRPLANNGKPQPQSEDVLFSILPPREFEKDGQRWVQYPSSTPATRLDVIRLQEQLDTLLADRQARETGVCPIREELYGQVFDELIRQVTISCAERGLLLLRVRDEIRMTLDAYRSLYESSIAFGMRKALHAEQAHVELEARVRALEREKADLQRQVEELVEECARIEQDEEQRRRDEQKKHDEEVAFFRRTYETLTANLQTVVNPSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GTD6</accession>
    <name>A0A836GTD6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ADP-ribosylation factor-like protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_07505</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">May play a role in apoptosis. May act as a tumor suppressor.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000004">
        <property type="protein sequence ID" value="KAG5487827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066024.1">
        <property type="nucleotide sequence ID" value="XM_067209392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GTD6"/>
    <dbReference type="SMR" id="A0A836GTD6"/>
    <dbReference type="GeneID" id="92363326"/>
    <dbReference type="KEGG" id="loi:92363326"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00878">
        <property type="entry name" value="Arf_Arl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000898">
        <property type="entry name" value="ADP-ribosylation factor-like protein 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0519">Myristate</keyword>
    <keyword evidence="2 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00072409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5487827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="190" mass="21013" checksum="6664DBF04C1A4209" modified="2021-09-29" version="1">MGNVISGWFESLFSNKKASIVMVGLDAAGKTTILDKLKLGTSRETVPTIGFHVETVDYRNVTFHLWDVGGQKRLRTLWRMYYEGANAVIFVVDSNDRARVGEVREELRTLLSDPLLAGAALLVLCNKQDLPQRLTPAELVDGLGFRDLSDNGLGRCLAGHKWYVQGCCAHTGDGLYEGLDWMCSHLPDNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GU74</accession>
    <name>A0A836GU74_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cullin neddylation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_00256</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058446.1">
        <property type="nucleotide sequence ID" value="XM_067202345.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92356279"/>
    <dbReference type="KEGG" id="loi:92356279"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cullin neddylation" evidence="2">
        <location>
            <begin position="1833"/>
            <end position="1900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="731"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="970"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1128"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1459"/>
            <end position="1509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1571"/>
            <end position="1626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1767"/>
            <end position="1793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="754"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="767"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1576"/>
            <end position="1591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1592"/>
            <end position="1603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1604"/>
            <end position="1614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5464815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1904" mass="204836" checksum="1DB1C42F2F4C1C5D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GU90</accession>
    <name>A0A836GU90_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">UAA transporter family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_07153</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000018">
        <property type="protein sequence ID" value="KAG5481441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064120.1">
        <property type="nucleotide sequence ID" value="XM_067209057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GU90"/>
    <dbReference type="GeneID" id="92362991"/>
    <dbReference type="KEGG" id="loi:92362991"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005462">
        <property type="term" value="F:UDP-N-acetylglucosamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005464">
        <property type="term" value="F:UDP-xylose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF4">
        <property type="entry name" value="NUCLEOTIDE SUGAR TRANSPORTER SLC35B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032610432" description="UAA transporter family protein" evidence="8">
        <location>
            <begin position="20"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5481441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="366" mass="39962" checksum="C44BAC1ED35CF0B9" modified="2021-09-29" version="1">MIMADAALGLLSIFCGCQANVFLLELIITGSPHTYYALTCAQYVCVACFTMPLLLRFKKPHERLGAASGIWPLRWRRSRVSLRHKLVLAVVGWAMSVGNNIVFGFHISIPLHATFRSSSLMLNMLAGYFFVGKRFTPPQVASALIICLGLITLTLERARRKDGTGVDAAPFTAAAASTPMWHWGCGVAILLATTACTAALSVFQEHMYRCARANEAAMAAAPAKEDAPPMWVEALCFSHLFAIPLFFLQPMRLYGEFAHIEAGSRLHVALNCVTQVVCIAGVYVMNDKTSAFTLTLTLTLRKLSSFVLSVVYFGHYRELSAVEWVAMVGALMAGTAYPFLPKVQHHASDTVGVSTATGARMMKKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GUG2</accession>
    <name>A0A836GUG2_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000020">
        <property type="protein sequence ID" value="KAG5480374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063705.1">
        <property type="nucleotide sequence ID" value="XM_067208065.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92361999"/>
    <dbReference type="KEGG" id="loi:92361999"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="772"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="989"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1117"/>
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        </location>
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            <begin position="1206"/>
            <end position="1232"/>
        </location>
    </feature>
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        </location>
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            <begin position="28"/>
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        </location>
    </feature>
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            <begin position="47"/>
            <end position="57"/>
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    </feature>
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        <location>
            <begin position="69"/>
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            <begin position="230"/>
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            <begin position="392"/>
            <end position="405"/>
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            <begin position="568"/>
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            <begin position="772"/>
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        </location>
    </feature>
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            <begin position="852"/>
            <end position="866"/>
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        <location>
            <begin position="871"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="1001"/>
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        </location>
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            <begin position="1136"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1534"/>
            <end position="1548"/>
        </location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5480374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1595" mass="166804" checksum="71F7392058376925" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GUL7</accession>
    <name>A0A836GUL7_9TRYP</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">LSCM4_00507</name>
    </gene>
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        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
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            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="loi:92356519"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
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            <begin position="140"/>
            <end position="163"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5465055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="163" mass="17657" checksum="F64CDF15B570A969" modified="2021-09-29" version="1">MPALPAAKGKDAAAAPKKKVHPPEPCGCDADTYRAPPRGKKSPAPIVHNTGCVYQRTTCDAYPHLPRCTTCQVPCKFCLGKNRWCPHCYEKQCTYRYKRVVIGQELLIGADMGPGKGEVTASLTRRGTSRRRTTVRFVGGKKSGSAAERDANAQRRGTNVAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GVC2</accession>
    <name>A0A836GVC2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Fibrillarin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_06392</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
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        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Fibrillarin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000019">
        <property type="protein sequence ID" value="KAG5480824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067208313.1"/>
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    <dbReference type="SMR" id="A0A836GVC2"/>
    <dbReference type="GeneID" id="92362247"/>
    <dbReference type="KEGG" id="loi:92362247"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:histone H2AQ104 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008649">
        <property type="term" value="F:rRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Fibrillarin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000677">
        <property type="entry name" value="Fibrillarin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA_methyltransf_FlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000692">
        <property type="entry name" value="Fibrillarin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020813">
        <property type="entry name" value="Fibrillarin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003276">
        <property type="entry name" value="PRK04266.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335:SF13">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335">
        <property type="entry name" value="RRNA 2-O-METHYLTRANSFERASE FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01269">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00052">
        <property type="entry name" value="FIBRILLARIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01206">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00566">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="75"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="75"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
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    </evidence>
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        </source>
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            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5480824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="362" mass="38516" checksum="04C61D68F710B7EF" modified="2021-09-29" version="1">MRFSTFSRAGPSSRFFLLSTLGVHTGRKHTRLHIPPSCCSRVVAHEHSDRRKADALIHTLPRSCNLAIMRGGRGGFGGRGGGGRGGVGRGGGRGGGRGGARGGGRGGGRGGGRGGRGGAGAPKGNIFHPHARFNGCYLLAGKDTLSTRSLVPGVSVYSEKRVNGTVAGESESHEFRVWNPYRSKLASAIYAGVASIYMEPGSAVLYLGAASGTTVSHVSDLVGPEGVVYAVEFSHRSGRDLEEMTKRRSNIVPILEDARYPQKYRMLIPRLVDCIFMDVAQPDQARILALNAQHFLKANGGFVISIKANCIDSTADPAAVFASEVQKLKDSGLRPKEQVSLEPFERDHCVVTGYYKNVPQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GVE3</accession>
    <name>A0A836GVE3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small ribosomal subunit protein uS15 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_02644</name>
        <name evidence="7" type="ORF">LSCM4_06422</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Bates M.D."/>
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                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
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                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="match status" value="4"/>
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    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="4">
        <location>
            <begin position="997"/>
            <end position="1444"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="1062"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="1100"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="1267"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="1308"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="286"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="338"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="443"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="580"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="628"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="659"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="788"/>
            <end position="894"/>
        </location>
    </feature>
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        <location>
            <begin position="1023"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="448"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="631"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="670"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="681"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="693"/>
            <end position="709"/>
        </location>
    </feature>
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        <location>
            <begin position="715"/>
            <end position="724"/>
        </location>
    </feature>
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        <location>
            <begin position="846"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="863"/>
            <end position="877"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5484859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1462" mass="151960" checksum="71EF0049151FC322" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H3U2</accession>
    <name>A0A836H3U2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein 18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_03062</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060632.1">
        <property type="nucleotide sequence ID" value="XM_067205080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H3U2"/>
    <dbReference type="GeneID" id="92359014"/>
    <dbReference type="KEGG" id="loi:92359014"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026721">
        <property type="entry name" value="TMEM18"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14770">
        <property type="entry name" value="TMEM18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5470366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="23578" checksum="4D086807BD6FD894" modified="2021-09-29" version="1">MSFLESLRAWVGKVEDELWAAHDEFMNATGARAFLDAAAMSSFSMDSLSEGFLQGIYNFYTAVNWSEPFFRYLCVFHIIVWVAAIAATWGAVSDERITVVCVVLVVLLLSGIPANSFAGRHAAWFFREPGVNYFTEDGIVMVVVYALPVLILLVCLQLRQICRLVSLMLQLKRAKLRLQRRREARGEGDSNANEESAAAEGGDVSGDSKKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H4A5</accession>
    <name>A0A836H4A5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_04564</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">LSCM4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 7">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062756.1">
        <property type="nucleotide sequence ID" value="XM_067206547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H4A5"/>
    <dbReference type="SMR" id="A0A836H4A5"/>
    <dbReference type="GeneID" id="92360481"/>
    <dbReference type="KEGG" id="loi:92360481"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000152">
        <property type="entry name" value="Protein phosphatase 2C, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320:SF37">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="3">
        <location>
            <begin position="80"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5477345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="370" mass="40840" checksum="73A36D5C9A14899C" modified="2021-09-29" version="1">MGARQSVPLLPNGQPSAQSQAQVNAVDVNSWGTPPDEAPEDEKDPTELVLQSWAFCKAKPTPQKMYRSDADERKRRQAVRWRKRASFIELDCGEDSFFVANNYKVIGVADGVGGWRSEGVDPSLFANALMENAKLFAETHRGERDPEKILDAAYTKVVKDGVVKVGSSTACVATLRKEDDGSHKLDVANLGDSGLMVVRNRDLHFRVHEKVHGFNAPFQLAVLPRSMVGRAFSDRVQDCVRESVPVQEGDVIVMGTDGLFDNRFNSELAADAGWIGKVEESPIAKIPLVGFFLSGILADEKIEYVDPYRVAQRVVSDAYKTSVNPQTNSPWASMLRQFGETDAKGGKPDDITVLLSRVCTREELHNSTSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H4B8</accession>
    <name>A0A836H4B8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_01859</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000022">
        <property type="protein sequence ID" value="KAG5479267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063360.1">
        <property type="nucleotide sequence ID" value="XM_067203901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H4B8"/>
    <dbReference type="GeneID" id="92357835"/>
    <dbReference type="KEGG" id="loi:92357835"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43289">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43289:SF6">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEKL-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1020"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="183"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="776"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="828"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="896"/>
            <end position="913"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5479267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1059" mass="113938" checksum="A8A212D5DD86ADFF" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H4T7</accession>
    <name>A0A836H4T7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="14">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">LSCM4_06322</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="14"/>
    <dbReference type="EMBL" id="JAFHLR010000007">
        <property type="protein sequence ID" value="KAG5486856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065650.1">
        <property type="nucleotide sequence ID" value="XM_067208245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H4T7"/>
    <dbReference type="SMR" id="A0A836H4T7"/>
    <dbReference type="GeneID" id="92362179"/>
    <dbReference type="KEGG" id="loi:92362179"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000104">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000128">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF486">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 14" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 14" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="12 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="350"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="805"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="834"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="875"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="909"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="948"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="979"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="16">
        <location>
            <begin position="63"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG5486856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1104" mass="122139" checksum="62D25066CDAFEA17" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H6P1</accession>
    <name>A0A836H6P1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AMP deaminase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_07479</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000004">
        <property type="protein sequence ID" value="KAG5487801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065998.1">
        <property type="nucleotide sequence ID" value="XM_067209366.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836H6P1"/>
    <dbReference type="GeneID" id="92363300"/>
    <dbReference type="KEGG" id="loi:92363300"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003876">
        <property type="term" value="F:AMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000035">
        <property type="entry name" value="Probable amp deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.800.20:FF:000003">
        <property type="entry name" value="Putative adenosine monophosphate deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006329">
        <property type="entry name" value="AMPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359:SF5">
        <property type="entry name" value="MONOPHOSPHATE DEAMINASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19326">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="250"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="606"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1837"/>
            <end position="1882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1978"/>
            <end position="2007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="266"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="620"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1839"/>
            <end position="1848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5487801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2007" mass="215447" checksum="8374C27CA9394A6E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H737</accession>
    <name>A0A836H737_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Integral membrane transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_06715</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000009">
        <property type="protein sequence ID" value="KAG5486009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065340.1">
        <property type="nucleotide sequence ID" value="XM_067208629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H737"/>
    <dbReference type="GeneID" id="92362563"/>
    <dbReference type="KEGG" id="loi:92362563"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050171">
        <property type="entry name" value="MFS_Transporters"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23517:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23517">
        <property type="entry name" value="RESISTANCE PROTEIN MDTM, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="432"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="456"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="517"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5486009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="602" mass="64232" checksum="37647144701FCF78" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H782</accession>
    <name>A0A836H782_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leucine-rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060802.1">
        <property type="nucleotide sequence ID" value="XM_067205250.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92359184"/>
    <dbReference type="KEGG" id="loi:92359184"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="680"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="731"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="770"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1147"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="741"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="788"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1183"/>
            <end position="1193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5471685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1616" mass="171941" checksum="3C88D872E8188818" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H899</accession>
    <name>A0A836H899_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein phosphatase type 1 regulator-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_08127</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000005">
        <property type="protein sequence ID" value="KAG5487679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065967.1">
        <property type="nucleotide sequence ID" value="XM_067210000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H899"/>
    <dbReference type="SMR" id="A0A836H899"/>
    <dbReference type="GeneID" id="92363934"/>
    <dbReference type="KEGG" id="loi:92363934"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000835">
        <property type="entry name" value="Protein phosphatase type 1 regulator-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454">
        <property type="entry name" value="NISCHARIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454:SF56">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="13"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5487679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="396" mass="45097" checksum="3F715B5CE91406C4" modified="2021-09-29" version="1">MFANLDEEKKTRLREKLLQAAAAPPPAYAPARSNSDSDGEREVPPQHNASTKHASEQLRVNAKSTEIEIANIRLFTLDELDLNQLTECKSLSLRKNLIHELSAFPQHLAGRLVELDLFDNKIRKVRDFFDSATVADPETGSLLKKPVPHAFSSLTKLDLSYNQLRKITGLDSLGSTLKELYLVENKIKVIEGLDNLVHLELLELGGNRIREIGSGLANLRALQSLWLGKNKINSIGDSLQNLRELRKLSLQANRLTIITEEVFKEGCNPYLIELYLSENGISTIENLPLHSLHLLDFSFNPIRTINEAVVNPTNMPELEEFWLTDGSISDWAEIRKFCGFSKTLRTIYVERNPIEQDKRYRDKVYMNLPFVTQIDSWPVLNKENLEADRLIQRKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H8K2</accession>
    <name>A0A836H8K2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_06284</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="JAFHLR010000007">
        <property type="protein sequence ID" value="KAG5486819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065613.1">
        <property type="nucleotide sequence ID" value="XM_067208208.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92362142"/>
    <dbReference type="KEGG" id="loi:92362142"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000021">
        <property type="entry name" value="Putative ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004146">
        <property type="entry name" value="DC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF67">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HUWE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03107">
        <property type="entry name" value="C1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="10">
        <location>
            <begin position="5896"/>
            <end position="6237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="370"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="468"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="868"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="967"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1345"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1394"/>
            <end position="1433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1790"/>
            <end position="1836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1880"/>
            <end position="1901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2080"/>
            <end position="2131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2249"/>
            <end position="2291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2548"/>
            <end position="2616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2932"/>
            <end position="2963"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2977"/>
            <end position="2996"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="3003"/>
            <end position="3024"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="3042"/>
            <end position="3073"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="3219"/>
            <end position="3238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="3454"/>
            <end position="3527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="3603"/>
            <end position="3624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="3715"/>
            <end position="3736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="3998"/>
            <end position="4024"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="4118"/>
            <end position="4246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="4266"/>
            <end position="4416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="4515"/>
            <end position="4574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="4606"/>
            <end position="4694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="4888"/>
            <end position="4913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="5063"/>
            <end position="5082"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="5100"/>
            <end position="5127"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="655"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="5573"/>
            <end position="5601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="398"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="433"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="934"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1345"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1357"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1798"/>
            <end position="1808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="1812"/>
            <end position="1821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1822"/>
            <end position="1833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="1884"/>
            <end position="1893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="2112"/>
            <end position="2131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="2252"/>
            <end position="2263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="2272"/>
            <end position="2282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="2549"/>
            <end position="2563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="2582"/>
            <end position="2592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="2593"/>
            <end position="2603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="2604"/>
            <end position="2616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="2977"/>
            <end position="2991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="3060"/>
            <end position="3073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="3229"/>
            <end position="3238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="3514"/>
            <end position="3527"/>
        </location>
    </feature>
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        <location>
            <begin position="4194"/>
            <end position="4207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="4209"/>
            <end position="4237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="4282"/>
            <end position="4295"/>
        </location>
    </feature>
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            <begin position="4375"/>
            <end position="4405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
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            <end position="4625"/>
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        </location>
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        <location>
            <begin position="4888"/>
            <end position="4907"/>
        </location>
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        <location>
            <begin position="5100"/>
            <end position="5123"/>
        </location>
    </feature>
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        <location>
            <position position="6204"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5486819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="6237" mass="667367" checksum="FE941F8530AA0D5F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H922</accession>
    <name>A0A836H922_9TRYP</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061011.1">
        <property type="nucleotide sequence ID" value="XM_067203974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H922"/>
    <dbReference type="GeneID" id="92357908"/>
    <dbReference type="KEGG" id="loi:92357908"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032766228" evidence="1">
        <location>
            <begin position="18"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5472615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="212" mass="23074" checksum="F182CB2DE246862F" modified="2021-09-29" version="1">MVAGALWLLALMDVFMGTGVDDLEEFGPVVSVTRSLIFVGDVRAMAASASPTPETRPHRSCSGTSRRRRAAAVGGGGFQHLRRARGESALLHWDVDLLYFRGPQCVTGLADCCRQDVEEGDVAHLQWHTKSSAARVTAGQQVLPTAPIVLQYVPASAVRCRGVHSLKRHVRHVICIEAAEHPARSSLFRPLYVCVRVCVCMCFVYSCDACPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HA28</accession>
    <name>A0A836HA28_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="4">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LSCM4_05597</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TOP6A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="4"/>
    <dbReference type="EMBL" id="JAFHLR010000016">
        <property type="protein sequence ID" value="KAG5482342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064348.1">
        <property type="nucleotide sequence ID" value="XM_067207534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HA28"/>
    <dbReference type="GeneID" id="92361468"/>
    <dbReference type="KEGG" id="loi:92361468"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000706">
        <property type="term" value="P:meiotic DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00223">
        <property type="entry name" value="TOPRIM_TopoIIB_SPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002815">
        <property type="entry name" value="Spo11/TopoVI_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013049">
        <property type="entry name" value="Spo11/TopoVI_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036078">
        <property type="entry name" value="Spo11/TopoVI_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034136">
        <property type="entry name" value="TOPRIM_Topo6A/Spo11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848:SF2">
        <property type="entry name" value="RECOMBINATION PROTEIN SPO11, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21180">
        <property type="entry name" value="TOP6A-Spo11_Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04406">
        <property type="entry name" value="TP6A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56726">
        <property type="entry name" value="DNA topoisomerase IV, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Spo11/DNA topoisomerase VI subunit A N-terminal" evidence="11">
        <location>
            <begin position="135"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Topoisomerase 6 subunit A/Spo11 TOPRIM" evidence="12">
        <location>
            <begin position="305"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="245"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="416"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="262"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="420"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF21180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG5482342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="649" mass="70222" checksum="ABD588ADDB8B1F45" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HA53</accession>
    <name>A0A836HA53_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GRAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000020">
        <property type="protein sequence ID" value="KAG5480390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063721.1">
        <property type="nucleotide sequence ID" value="XM_067208081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HA53"/>
    <dbReference type="GeneID" id="92362015"/>
    <dbReference type="KEGG" id="loi:92362015"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5480390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="335" mass="36227" checksum="A47146AB6DDB2112" modified="2021-09-29" version="1">MPLSSSGGATPTTPPAPTSSAADKHALQDPRGFRRAAVLTYHTAPYPSNSIDGIFEALLMLAADRLGPNGEVVKEKTSNRTSRAEKGGWLGRAWKHVVSYTSSNLLQIRQAAFFNAFSRQLELNPAEESSIVMVSCQCFIVSDGKMRFGSLFATNCGLYFCSCEPQAAPAATTAAEANASSNSSADNRVEGEVDYIKERVLFTDVASLLPSISLEQKGTIAPFIQGIPSGVVAPTALQVFTVQLSTVLQFVGLHKVAVKRPTRSAAEAERGSGDTGQDAPYTDVVQKREFNLICELPCNLDTLKFCALLWRLWAQRLHQLGRPLENPAVHYAEPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836HF25_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_04170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG5475588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067206159.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="92360093"/>
    <dbReference type="KEGG" id="loi:92360093"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5475588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="132" mass="15001" checksum="87913CAEAB7EDF64" modified="2021-09-29" version="1">MKRSQIPFEQRAVRRGLTYTPPERQRLLSIRSCRTSKRRLTDERQPSSARSSSSGKGSLRGRRGVDCGRLSTQSGWLNWMHARPASGDPAPDLAPSWMPTCAHWHASTAHCTWRCYGIGRRLSLLCPRRPFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HG59</accession>
    <name>A0A836HG59_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_04454</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Discoba</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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            <end position="796"/>
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        <location>
            <begin position="874"/>
            <end position="891"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="962" mass="103583" checksum="768A4E007F1E4757" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HHG1</accession>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5477941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A836HHG1"/>
    <dbReference type="GeneID" id="92361214"/>
    <dbReference type="KEGG" id="loi:92361214"/>
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            <end position="64"/>
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            <end position="226"/>
        </location>
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    <feature type="compositionally biased region" description="Gly residues" evidence="1">
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            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
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        </location>
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            <end position="187"/>
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            <begin position="201"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5477941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="226" mass="24602" checksum="56C286C1429610B3" modified="2021-09-29" version="1">MDKVKTLEVLRGMKFMQRKEEAKRRAAFEVAQREQIERQLLHTGTGSSGASGGPSDGGSFALRPYRSGGQARATVLYDDTFPAYAYGLSRRSFTEAMGGGGGGAVSIAAESETLLKGVDPSPTSRDAALDDSDFASGEEVEDLWGGVDDESAVDYLTAAPDRRRQGGEKSRECRGDRDQHARSDGRFIVKSSLRAPKLPRRLQESVEEQERQRKRKRAEGEGDAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HHT5</accession>
    <name>A0A836HHT5_9TRYP</name>
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            <fullName evidence="1">Complex 1 LYR protein domain-containing protein</fullName>
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        <name evidence="2" type="ORF">LSCM4_07962</name>
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    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000013">
        <property type="protein sequence ID" value="KAG5484395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067209838.1"/>
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    <dbReference type="GeneID" id="92363772"/>
    <dbReference type="KEGG" id="loi:92363772"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13232">
        <property type="entry name" value="Complex1_LYR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="1">
        <location>
            <begin position="30"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5484395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="201" mass="23987" checksum="8B4D62F0AC0B876B" modified="2021-09-29" version="1">MAPGGMLHTSLIARRAATEATAAPVFYRRQEKIRLYRSLLKGAHRFPMRSRREVITEEVRSTFRDPNNEHLSEKDIDYRLILGWERAKSIATYAENMHWFHSRDEVTKEMMYFSEERDRKRAAEMLHFNQVGDVRRKTDEVTEFRSTYYNVHPDYHSKIGQKPLTHSRDVWRARGQYGSDVGGPRQRFFVRRFKAMFPQGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HKG3</accession>
    <name>A0A836HKG3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Membrane-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_04713</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
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                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
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            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG5482305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="ANK_REPEAT"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="250"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5482305.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="495" mass="56150" checksum="B66E79B0838525E9" modified="2021-09-29" version="1">MKQGKSRMERLREASHVSDLPAIIKLIMQRNIDIRKPDACGRTALHYACLNDNRILVSYLLSRGDIDVDLKDRDGKTALQLTPEASRSDMRLLFSKMAASRQARERQSTQKGMEANEQMLVEDLRESDKVSPATMRKIVACLTLPLLILIFYNGIVFAVQFIALTLCFYYFAVAYFVSEVAIRPPWYHHHPGASALTMKGCPDYWQGWIYDPKTDFGLEYEDVEFASTDYYKLRGWYVPPPQGKAREMGIVLVHGGGRDRRSWERHVPFLHNAGYGCLLFDFREHGLSSGKMRGFTFGMKERFDVVAACDLMQSKYGYKRICAMGTSVGGSSVIMAAAIDKNIDVVIAENAITTSATLLDQQIVKVLGGYFAQKRYSVEVFRLFRRCATFWLNWRIGNKPSKHCQALHCIAKISPRPILLMHGTSDTLVPMRHSEILFEAALWPKQLYLCEGAFHCGLYNTRPDEYEATVLEFLEKYGVASPSPSSPPNEAKKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HWG8</accession>
    <name>A0A836HWG8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial pyruvate carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_04978</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Mediates the uptake of pyruvate into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000014">
        <property type="protein sequence ID" value="KAG5483823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064762.1">
        <property type="nucleotide sequence ID" value="XM_067206953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HWG8"/>
    <dbReference type="GeneID" id="92360887"/>
    <dbReference type="KEGG" id="loi:92360887"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006850">
        <property type="term" value="P:pyruvate import into mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005336">
        <property type="entry name" value="MPC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03650">
        <property type="entry name" value="MPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5483823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="139" mass="15395" checksum="23C618FCDAA509E9" modified="2021-09-29" version="1">MSTVTGHTIPKMFPRVFHSWVGHGRIFNFLAPYERNPAVAYLNSIYNTAPLFKWSLSIVPLYGIVSGNPPVEKVDLNSSAALCATGIVWFIYALLIQPQNSGSRSLALVNLCLASVNGYNCYRSARYKRSQAALVKNIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HXV8</accession>
    <name>A0A836HXV8_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_07627</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000012">
        <property type="protein sequence ID" value="KAG5484855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064967.1">
        <property type="nucleotide sequence ID" value="XM_067209507.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92363441"/>
    <dbReference type="KEGG" id="loi:92363441"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="629"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="701"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="819"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="941"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1026"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1213"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1250"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1294"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="637"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="941"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="959"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1055"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1087"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1213"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1225"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1250"/>
            <end position="1259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5484855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1357" mass="142491" checksum="1B88EEEDD396A274" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HZC0</accession>
    <name>A0A836HZC0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Isocitrate dehydrogenase [NADP]</fullName>
            <ecNumber evidence="10">1.1.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LSCM4_06576</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="10 13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="10 13">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="10"/>
    <dbReference type="EMBL" id="JAFHLR010000010">
        <property type="protein sequence ID" value="KAG5485620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065204.1">
        <property type="nucleotide sequence ID" value="XM_067208493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HZC0"/>
    <dbReference type="SMR" id="A0A836HZC0"/>
    <dbReference type="GeneID" id="92362427"/>
    <dbReference type="KEGG" id="loi:92362427"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006739">
        <property type="term" value="P:NADP+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000016">
        <property type="entry name" value="Isocitrate dehydrogenase [NADP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004790">
        <property type="entry name" value="Isocitrate_DH_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00127">
        <property type="entry name" value="nadp_idh_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006156">
        <property type="entry name" value="PRK08299.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822:SF21">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NADP], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822">
        <property type="entry name" value="NADP-SPECIFIC ISOCITRATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000108">
        <property type="entry name" value="IDH_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 10 13" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10 14" id="KW-0521">NADP</keyword>
    <keyword evidence="7 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="15">
        <location>
            <begin position="35"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="101"/>
            <end position="103"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="120"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
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    <feature type="binding site" evidence="14">
        <location>
            <begin position="334"/>
            <end position="339"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="11">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="11">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022857"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023554"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR000108"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG5485620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="435" mass="48639" checksum="4E37166362B9B75B" modified="2021-09-29" version="1">MLRRASVASASKLAATRTFSTTPVALHKRIKVKNEIVDMDGDEMTRIIWSLIKEKLILPYVDIPIHYFDLSVTHRDATDDKVTIDAAEAIKKCNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIIGNIPRIVSQWKEPIVVGRHAFGDQYKATDAIFKPGKLQLVHTPADGSEPTTLEVYDFKSEGVGMAMYNTKESIEGFATSCFQYALMRKYPLVLTTKNTILKKYDGMFLQTFQRLYDEQYKADFEKVGITYNHRLIDDQVAQMIKGEGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYRQHQQGKETSTNSVASIYAWTRGLAHRGRLDGNSELVKFSETLEKVVIKTIESGHMTKDLALCVHGSSGVKRDQYETTEEFLDSVEAALKKAMNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836I2P5</accession>
    <name>A0A836I2P5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP-NAD kinase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_07744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000006">
        <property type="protein sequence ID" value="KAG5487255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065752.1">
        <property type="nucleotide sequence ID" value="XM_067209622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836I2P5"/>
    <dbReference type="SMR" id="A0A836I2P5"/>
    <dbReference type="GeneID" id="92363556"/>
    <dbReference type="KEGG" id="loi:92363556"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10330:FF:000047">
        <property type="entry name" value="ATP-NAD kinase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.30:FF:000016">
        <property type="entry name" value="Inorganic polyphosphate/ATP-NAD kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF0">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="821"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="952"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="443"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="821"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="952"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="989"/>
            <end position="1001"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5487255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1278" mass="135856" checksum="17ABF4C874A41109" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836I5C9</accession>
    <name>A0A836I5C9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">oligopeptidase A</fullName>
            <ecNumber evidence="8">3.4.24.70</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_08198</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Hydrolysis of oligopeptides, with broad specificity. Gly or Ala commonly occur as P1 or P1' residues, but more distant residues are also important, as is shown by the fact that Z-Gly-Pro-Gly-|-Gly-Pro-Ala is cleaved, but not Z-(Gly)(5).</text>
            <dbReference type="EC" id="3.4.24.70"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the peptidase M3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.70" evidence="8"/>
    <dbReference type="EMBL" id="JAFHLR010000002">
        <property type="protein sequence ID" value="KAG5488218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066266.1">
        <property type="nucleotide sequence ID" value="XM_067210068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836I5C9"/>
    <dbReference type="SMR" id="A0A836I5C9"/>
    <dbReference type="GeneID" id="92364002"/>
    <dbReference type="KEGG" id="loi:92364002"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06456">
        <property type="entry name" value="M3A_DCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000009">
        <property type="entry name" value="Oligopeptidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034005">
        <property type="entry name" value="M3A_DCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43660">
        <property type="entry name" value="DIPEPTIDYL CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43660:SF1">
        <property type="entry name" value="DIPEPTIDYL CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="10">
        <location>
            <begin position="227"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5488218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="678" mass="76232" checksum="A5C0C93013445A22" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836K7R9</accession>
    <name>A0A836K7R9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cysteine desulfurase</fullName>
            <ecNumber evidence="3">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_01471</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="3"/>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059214.1">
        <property type="nucleotide sequence ID" value="XM_067203523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836K7R9"/>
    <dbReference type="SMR" id="A0A836K7R9"/>
    <dbReference type="GeneID" id="92357457"/>
    <dbReference type="KEGG" id="loi:92357457"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="CYSTEINE DESULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601">
        <property type="entry name" value="CYSTEINE DESULFURYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="10">
        <location>
            <begin position="25"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5466324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="455" mass="48936" checksum="D37E9067ACBE5BB5" modified="2021-09-29" version="1">MCNAQGPPLKKRKPQPLPLTEPVPIYLDHNATTPLCEEAWREMCRVHKTWGNPSSTHPYGLAAKYELEGSRTKLREALNAPSSGSIVFTSGGTESNNLAILGGTIALRQRQPRRRYVVSTNVEHPAVAEVLRFMEGRDLGARCTSGIVDGAEAAPLTKVKAVRVAVNAQTGCLDAGDLRECLKRLPGGPASVALVSVMFANNEIGAVNDIKELCRVTKELCGSDCLFHTDAAQSLGKVPVDVRDTNVDFLSVCGHKFYGPKGVGALYIKPGVAVHNILFGAGHERGIRPGTENVLLAAGLAEALLFACKNMDRFSAVMRETRDEMLRVLKVELAAHDMDLVVNGDVAFALPNTLNCALFKRVPNTKTGSPVTYISAQRLILSTGDEVCVSAGSACHSTADEDTEIVISDPLMAVQVKLDRAIGTLRISTGRTTTIDEVRRAGKIIARRAAQQFSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KA74</accession>
    <name>A0A836KA74_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Memo-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_00117</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MEMO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058308.1">
        <property type="nucleotide sequence ID" value="XM_067202207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KA74"/>
    <dbReference type="SMR" id="A0A836KA74"/>
    <dbReference type="GeneID" id="92356141"/>
    <dbReference type="KEGG" id="loi:92356141"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07361">
        <property type="entry name" value="MEMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.830.10:FF:000005">
        <property type="entry name" value="AmmeMemoRadiSam system protein B, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00055">
        <property type="entry name" value="MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002737">
        <property type="entry name" value="MEMO1_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04336">
        <property type="entry name" value="AmmeMemoSam_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060:SF0">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01875">
        <property type="entry name" value="Memo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5464677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="370" mass="41262" checksum="9004BE409A122819" modified="2021-09-29" version="1">MQSHKHTRARAKHTSRTQSVFSTARHSPALLSHQTTPPAKARMTFLRPATHAAPNGCGWYEAIPQRLKATIDDYFSETTHHYDDESVGCTRMTALIAPHAGMSYSGRTASEAFAVLREYLYAKGSKGRDLERVFILGPSHTKGFEGCELSAASEYETPFGPLKVDTAAVEQVIAALRKAGVGASTASRRTDEAEHSIEMETPYLSHILHYPPPTVSASVLPAAGRVSIVPIIVGWTDRQVEKAICDALKPYMEDARNFFIFSSDFCHWGNRFSYMHHYKRSEYPNIGDSIIAMDHAAMELLERRDLEGWYSYLKTTKNTICGRAPISVGMQRWADEAIKARVRFVHYSQSNKCEDTDDSSVSYAAAIVME</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KBP9</accession>
    <name>A0A836KBP9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA N(3)-methylcytidine methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_01553</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">S-adenosyl-L-methionine-dependent methyltransferase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the methyltransferase superfamily. METL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059292.1">
        <property type="nucleotide sequence ID" value="XM_067203601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KBP9"/>
    <dbReference type="SMR" id="A0A836KBP9"/>
    <dbReference type="GeneID" id="92357535"/>
    <dbReference type="KEGG" id="loi:92357535"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026113">
        <property type="entry name" value="METTL2/6/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809:SF5">
        <property type="entry name" value="TRNA N(3)-METHYLCYTIDINE METHYLTRANSFERASE METTL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037755">
        <property type="entry name" value="Mettl2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR037755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5466402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="370" mass="40809" checksum="0C526A765E638250" modified="2021-09-29" version="1">MPAATDSEATTQLSRAASSPCLRDASNGRRRARSPSYAPFVDEYRPYSGGQLQTHRVNRHTDLHKRQWDLYYRNNTVNGYKDRHYILREFHELRAAIDAAVATEEKAFKAGNATPSKSGASLSPAPSFSWMEAGCGVGNAMLPVFAQYGHLRQWRALLGFDISSVAIALLEEKLAVWPPALAAKVHVCVLNPSESEVTDCPFFTSKGVSAAALSSSSMGVADSGTAEAVRRAPVCELPEFVSLIFVLCSIPVSSHAIVLRRVARCMARPEGVLYFRDYAVSDHAEHRFQSSLHRRRGDRGDGDDTGDTNTYERTNGTLTHFFSLGEVRSLFEDAGFEVVALDIIANEVTNRKTGVSFARRFVQGRFRLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KD28</accession>
    <name>A0A836KD28_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Replication factor A protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_01535</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the replication factor A protein 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059275.1">
        <property type="nucleotide sequence ID" value="XM_067203584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KD28"/>
    <dbReference type="SMR" id="A0A836KD28"/>
    <dbReference type="GeneID" id="92357518"/>
    <dbReference type="KEGG" id="loi:92357518"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013970">
        <property type="entry name" value="Rfa2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08661">
        <property type="entry name" value="Rep_fac-A_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5466385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="117" mass="13125" checksum="6231BF111E5C25C9" modified="2021-09-29" version="1">MYAQHIQSAPSIKLPLFQGVSPRVTAQTYHSHRGEYVSIIFELTGPGEFKCGATGMSVKVVGVPEAVEVSRVCEFICYVDPSTGELTYFQHAMLDDEFDFEVYRRLVSLTTKVPQLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KDX2</accession>
    <name>A0A836KDX2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nucleoside diphosphate kinase</fullName>
            <ecNumber evidence="9">2.7.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_02981</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the NDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="9"/>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060552.1">
        <property type="nucleotide sequence ID" value="XM_067205000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KDX2"/>
    <dbReference type="SMR" id="A0A836KDX2"/>
    <dbReference type="GeneID" id="92358934"/>
    <dbReference type="KEGG" id="loi:92358934"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04413">
        <property type="entry name" value="NDPk_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.141:FF:000002">
        <property type="entry name" value="Nucleoside diphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001908">
        <property type="entry name" value="PRK00668.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11349">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="10">
        <location>
            <begin position="3"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="7">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5470286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="151" mass="16674" checksum="F92B9BB13801ABB7" modified="2021-09-29" version="1">MSSERTFIAIKPDGVQRGLVGEIISRFERKGFKLVAMKMLQPTTEQAQGHYKDLASKPFFPGLVEYFSSGPIVCMVWEGKNVVKSGRTLLGATNPADSQPGTIRGDFAVDVGRNVCHGSDSVESAQREIAFWFKPEEIASWTSHSACQIYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KDZ6</accession>
    <name>A0A836KDZ6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-hydroxyisobutyryl-CoA hydrolase</fullName>
            <ecNumber evidence="2">3.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_03057</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20888"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57340"/>
            <dbReference type="EC" id="3.1.2.4"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.4" evidence="2"/>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060627.1">
        <property type="nucleotide sequence ID" value="XM_067205075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KDZ6"/>
    <dbReference type="SMR" id="A0A836KDZ6"/>
    <dbReference type="GeneID" id="92359009"/>
    <dbReference type="KEGG" id="loi:92359009"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003860">
        <property type="term" value="F:3-hydroxyisobutyryl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032259">
        <property type="entry name" value="HIBYL-CoA-H"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004127">
        <property type="entry name" value="PRK05617.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176:SF3">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl-CoA hydratase/isomerase" evidence="4">
        <location>
            <begin position="21"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5470361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="371" mass="40468" checksum="47777DB46C6B8FB0" modified="2021-09-29" version="1">MRCSGSRWSTKVLCKDYPHARHITLNRPSALNALDYDMIRELHRLYVTEPAPLSSLYILTGAGTKAFCAGGDVVGLTTNIPPRCGCDFFYQEYQVDYKVGRIPAGQVCLWDGFVLGGGVGLSIGSAYRVASEKAQFAMPEVAIGMFPDVGASWFLPRLSVPGLGLYMALTGHRLRGADLVHLGLATHFVPSARMRELEQALISMSNADGVEAVLDTYAVPAAQLPPCTIAQSFCSLAKHFDITADQTISSIMDACLSHSQTDPLTKAAAHLMPTFSPTAMTLALELLKRGVKASTATEVHQMEYCASQRVIEEHDFREGVRAMLIDKDKKPKWQPATLAEVTAEAIDAYFQPATPDQLVWDPVKPFAERVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KEI5</accession>
    <name>A0A836KEI5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_00971</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059687.1">
        <property type="nucleotide sequence ID" value="XM_067203037.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92356971"/>
    <dbReference type="KEGG" id="loi:92356971"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF388">
        <property type="entry name" value="GOLGI-SPECIFIC BREFELDIN A-RESISTANCE GUANINE NUCLEOTIDE EXCHANGE FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="2">
        <location>
            <begin position="664"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1265"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1682"/>
            <end position="1707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5467885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1871" mass="199948" checksum="76EF853A7214DCA9" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KEV0</accession>
    <name>A0A836KEV0_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
            <dbReference type="EMBL" id="KAG5470032.1"/>
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        </source>
    </evidence>
    <sequence length="374" mass="40680" checksum="FE0751ACEC5B629A" modified="2021-09-29" version="1">MERGPRSSSGGPDGGFCALHGKRRSRADLIAWNQQPGKMRCLSQKECHVRSEHRRASGREQGRASGGGGGDMRERERRGGMSRGSGVRERGGRRERGDRNDRRDRGDRGDTVLCRLHRQRRTARQMREVGAGVFECTEGTRCKQTGDRRIGAAGGRGGDDRGRMRDQRGPSFVERGGGPRTRQRRAERAPRPPHAQRYDDGTAAAWAPSAGTGAVGSGAARRRTCKAERKVWCALHGKHLPASQCEFVQDCCYVCLDPSTCLATPLEAPTMLITRGCVEVLCSRHHTLRSAGFVELTEKPVAYQCMPGHACRGVTVPHMGQEASGATAGAVGGPAALPYAMADMDDDEEVYMGARANNTFLPQSGREVVSSFFM</sequence>
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        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
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                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471666.1"/>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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            <end position="78"/>
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    </feature>
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        <location>
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        <location>
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            <end position="545"/>
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            <end position="72"/>
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        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="694" mass="74810" checksum="1B8DCC1579535C0B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KHB0</accession>
    <name>A0A836KHB0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_04984</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476029.1"/>
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        <property type="nucleotide sequence ID" value="XM_067206959.1"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:U6 snRNP"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="Lsm7/SmG-like"/>
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        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
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        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553:SF5">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="3">
        <location>
            <begin position="39"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5476029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="114" mass="12588" checksum="F015C5195E5316F8" modified="2021-09-29" version="1">MSPCAVTERQLELRRLNHRVAKIMSAEAAHILKKKEGILSLEKYLDRKVVVSQKGHEVHGVLKGFDNNVNLVLADAELWHRNTRIRTIGACVVRGGPVNLVLSGDVAVIANPFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KHL6</accession>
    <name>A0A836KHL6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">6-phosphogluconolactonase</fullName>
            <shortName evidence="2">6PGL</shortName>
            <ecNumber evidence="2">3.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_05281</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="3.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.31" evidence="2"/>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062532.1">
        <property type="nucleotide sequence ID" value="XM_067207229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KHL6"/>
    <dbReference type="SMR" id="A0A836KHL6"/>
    <dbReference type="GeneID" id="92361163"/>
    <dbReference type="KEGG" id="loi:92361163"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00409"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01400">
        <property type="entry name" value="6PGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000027">
        <property type="entry name" value="6-phosphogluconolactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005900">
        <property type="entry name" value="6-phosphogluconolactonase_DevB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039104">
        <property type="entry name" value="6PGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01198">
        <property type="entry name" value="pgl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054:SF0">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="3">
        <location>
            <begin position="15"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU365095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5476299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="267" mass="28741" checksum="1898D31F1AA7C72F" modified="2021-09-29" version="1">MAFFAPTVKVCEDISQMSSIAREIILAAIHARVDKSAPVVVALSGGSTPRKLYEDLHEKDLALLQQHTVLFILGDERLLAADDEQSNYSMAAKALLRDVPSMDVIPVDPTAALDTSKDEACGLTGAWAVAEDYETKLLNRLPCRKIEGTSKRVPVVDIVLLGFGSDGHTASIFPHSVAATDADHVVSVSFPSPTMSPKVWRVTLSKTAIRHARHVIVLACGKDKNWVVRGVLAQTPPDPEPVARFLRDCRGSVTMLLDHGSGEGVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KI83</accession>
    <name>A0A836KI83_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060782.1">
        <property type="nucleotide sequence ID" value="XM_067205230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KI83"/>
    <dbReference type="GeneID" id="92359164"/>
    <dbReference type="KEGG" id="loi:92359164"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5471665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="65" mass="7217" checksum="5AF58322E7511D51" modified="2021-09-29" version="1">MRIHYGDNRAEELRVRGGAADAPSRVALRLLLTDDSDAVDGGRGAERDRRVKRQRDRTPGALLDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KK24</accession>
    <name>A0A836KK24_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_04373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062567.1">
        <property type="nucleotide sequence ID" value="XM_067206358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KK24"/>
    <dbReference type="GeneID" id="92360292"/>
    <dbReference type="KEGG" id="loi:92360292"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="888"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="259"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="984"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1030"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1052"/>
            <end position="1064"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5477156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1064" mass="115347" checksum="14AE0A008E7D63A4" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KK56</accession>
    <name>A0A836KK56_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cullin family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_04479</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">LSCM4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062672.1">
        <property type="nucleotide sequence ID" value="XM_067206463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KK56"/>
    <dbReference type="GeneID" id="92360397"/>
    <dbReference type="KEGG" id="loi:92360397"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cullin family profile" evidence="5">
        <location>
            <begin position="647"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="541"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="725"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="893"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="725"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="923"/>
            <end position="934"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5477261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1058" mass="114428" checksum="1D28CA049C4970B2" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KK88</accession>
    <name>A0A836KK88_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_04585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062777.1">
        <property type="nucleotide sequence ID" value="XM_067206568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KK88"/>
    <dbReference type="GeneID" id="92360502"/>
    <dbReference type="KEGG" id="loi:92360502"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5477366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="534" mass="57316" checksum="86A55520D5118783" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KKW7</accession>
    <name>A0A836KKW7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_05486</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5478086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062993.1">
        <property type="nucleotide sequence ID" value="XM_067207425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KKW7"/>
    <dbReference type="SMR" id="A0A836KKW7"/>
    <dbReference type="GeneID" id="92361359"/>
    <dbReference type="KEGG" id="loi:92361359"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000154">
        <property type="entry name" value="Hypothetical_protein_-_conserved"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12763">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12763:SF28">
        <property type="entry name" value="GEO10507P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5478086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="121" mass="13481" checksum="36183314762D8259" modified="2021-09-29" version="1">MALPIISGILVGCGIYYVSRVGPRIAQRVSTSGAKSASSHFLSDSKPYHKFECGFQSPMTEYEAYMLLGFKENEAGAILRRPTPEEVKKRYRNMMKGFHSDVSGTPYIATKLNEAKDILIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KM05</accession>
    <name>A0A836KM05_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_06236</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000020">
        <property type="protein sequence ID" value="KAG5480469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063800.1">
        <property type="nucleotide sequence ID" value="XM_067208160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KM05"/>
    <dbReference type="GeneID" id="92362094"/>
    <dbReference type="KEGG" id="loi:92362094"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5480469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="265" mass="30092" checksum="E7565828FEAE9AFF" modified="2021-09-29" version="1">MASVQLVRRRTSSELSQTERMALRAEERARGHSSKLAAHALSRIKRGVYTNTDVHTLLEQLFLHPPTMVPQRYLIDSPSSKATSRSKQHRRISSALTHNRSYVRQLRCKHRSSTASHYFHVPQTPLPLSFEAQRDIDYVTGRQRCGRLQVGSGYAPLFSMLNTWTPEASTAVERRALQFLKPPERSPMVETLERLASQAHYKPSDPMARIRVNEPAHLPDLHRRAPAEFVPACSKMPTVCFAKHCEGNEDRAACSKAARKYAAWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KME0</accession>
    <name>A0A836KME0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_05712</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063417.1">
        <property type="nucleotide sequence ID" value="XM_067207644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KME0"/>
    <dbReference type="SMR" id="A0A836KME0"/>
    <dbReference type="GeneID" id="92361578"/>
    <dbReference type="KEGG" id="loi:92361578"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38148">
        <property type="entry name" value="BAR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38148:SF3">
        <property type="entry name" value="BAR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5479706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="26240" checksum="31262B05FF772CD3" modified="2021-09-29" version="1">MKKFVLDTKAAFGVAPKTVDWDFDEKSNNVKNIHQTLSIYISALEQMKTASQSLLTAMDNMSKALGTMTAEHGVPEAMRFVAVEYTELVRKGIFEHLVDFKKTIDDDESIAEMMNLAAKCKSLAAKRKKVMSEYDAYRDAVCKKEVQYRKKGKDLSGSKYYDEEVARRDSLRADFEKADNDFKSTYDVLEEKRLSSYMAAISVFLGCTLQLISSIEKEMRAVKRKADTVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KMY6</accession>
    <name>A0A836KMY6_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000020">
        <property type="protein sequence ID" value="KAG5480321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063652.1">
        <property type="nucleotide sequence ID" value="XM_067208012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KMY6"/>
    <dbReference type="GeneID" id="92361946"/>
    <dbReference type="KEGG" id="loi:92361946"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="737"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="272"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="319"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="512"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5480321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1220" mass="129162" checksum="912060B38B61480D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KN20</accession>
    <name>A0A836KN20_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endo-1,4-beta-xylanase z-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_06193</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000020">
        <property type="protein sequence ID" value="KAG5480426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063757.1">
        <property type="nucleotide sequence ID" value="XM_067208117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KN20"/>
    <dbReference type="SMR" id="A0A836KN20"/>
    <dbReference type="GeneID" id="92362051"/>
    <dbReference type="KEGG" id="loi:92362051"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050583">
        <property type="entry name" value="Mycobacterial_A85_antigen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48098:SF1">
        <property type="entry name" value="DIACYLGLYCEROL ACYLTRANSFERASE_MYCOLYLTRANSFERASE AG85A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48098">
        <property type="entry name" value="ENTEROCHELIN ESTERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5480426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="420" mass="45920" checksum="E17FFC6F6F83CA5E" modified="2021-09-29" version="1">MSTVVVTAASPTSAQPLALPSRTSATHLPSFDQPAQPQQQLLFQPCCEEGVTYSKDSHGTVDYRFYFPHASSVAVAPVTVHLVERGGCTVPVASIGIAAPMARHQDGVWVGATSAPVGLQCVVLIVDGSPVLSPHLSIGYLHGLQRANYIDVPPPNPSPCIYALRPSVEHGTVSHDYVTSYTMDTTEEVLIYVPPSYHKAGSATRRYPVLYLLHDDREQVINCIQHGKVNVIADNLVASGAMREMIMVMKSSVCSSSDGECLPCDAARLCEDLTEDIIPYIDNHYRTEADRDNRAITGLCMGSIHASRLCMTRHDLFAYAGVLSGLLRTSWSGIGADDHIEALRRDPVAFQASMKVLFRCIGDDDTLRALFEVDDALLAELGVPCERRVYTGSYSWQVWRQAAADFLPMLFKDLNSPCRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KNF9</accession>
    <name>A0A836KNF9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GDT1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_06414</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GDT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000019">
        <property type="protein sequence ID" value="KAG5480846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063847.1">
        <property type="nucleotide sequence ID" value="XM_067208335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KNF9"/>
    <dbReference type="GeneID" id="92362269"/>
    <dbReference type="KEGG" id="loi:92362269"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015085">
        <property type="term" value="F:calcium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032468">
        <property type="term" value="P:Golgi calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032472">
        <property type="term" value="P:Golgi calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001727">
        <property type="entry name" value="GDT1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049555">
        <property type="entry name" value="GDT1-like_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN HTP-1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01169">
        <property type="entry name" value="GDT1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01214">
        <property type="entry name" value="UPF0016"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5480846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="251" mass="26851" checksum="A9E97BBA5025A76A" modified="2021-09-29" version="1">MDLRKSTNLIDGFLSSLSMILVSEIGDKTFFIACLMSMRHPKMTVYVGALGALAAMTVLSALMGVVVPNLLSVQVTQMLAVVLFMAFGGKILYDELIRKKADDEESEDEMSEAAAALRRRDPNDAAETGSIASSAYVSAPARRWRKLLNPVMVEAFTLTFVAEWGDRSQLATIALAAAKNAYGVTVGGILGHALCTGGAVLCGNLIAQRVSMKTVNIVGGVLFIVFGLVTFYELAYGEHEIAKTHEIPKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KNP6</accession>
    <name>A0A836KNP6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Coiled-coil domain-containing protein 66</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063538.1">
        <property type="nucleotide sequence ID" value="XM_067207765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KNP6"/>
    <dbReference type="SMR" id="A0A836KNP6"/>
    <dbReference type="GeneID" id="92361699"/>
    <dbReference type="KEGG" id="loi:92361699"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043614">
        <property type="term" value="C:multi-eIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027512">
        <property type="entry name" value="EIF3A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14005:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14005">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3, THETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="519"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="747"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="603"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="774"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5479827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="795" mass="83666" checksum="66DBD1A8377A73AE" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KNZ2</accession>
    <name>A0A836KNZ2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Oligomerization domain family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_02131</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Iojap/RsfS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061204.1">
        <property type="nucleotide sequence ID" value="XM_067204167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KNZ2"/>
    <dbReference type="SMR" id="A0A836KNZ2"/>
    <dbReference type="GeneID" id="92358101"/>
    <dbReference type="KEGG" id="loi:92358101"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090071">
        <property type="term" value="P:negative regulation of ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000137">
        <property type="entry name" value="Uncharacterized protein L5213T.03"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004394">
        <property type="entry name" value="Iojap/RsfS/C7orf30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21043">
        <property type="entry name" value="IOJAP SUPERFAMILY ORTHOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21043:SF0">
        <property type="entry name" value="MITOCHONDRIAL ASSEMBLY OF RIBOSOMAL LARGE SUBUNIT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02410">
        <property type="entry name" value="RsfS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="170"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5472808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="367" mass="40501" checksum="62A821FF2C32CEC5" modified="2021-09-29" version="1">MFCRGTALQPALMRARLTSLALRAPHRWLFSVSSAHLRPTHVPLAEDDNFVDVDHLMGLAAATRNPAPAGDSAPTSSGSTEVARSEVLGVVRVEPVEEGTRYSRLRIPLNADETAAARPRACTRAGLALGEEAAYADTAVDSSANSAVELASSPSSSATGSAEVATTEGFRSEERRLPDPSRLPYDDERFAEMLLEMEVNGVIDETWQDASKARLEDVKEIADILTSLKVRDLCCIDVSEKTSNFDYMMFGTCEGARHIHLAAWAVQDADKAHRISKIKRKQTDELWEVVPVGRIVVNLMVESFREEMTLERKWAVTRSMDPLAAANAPISEGRQVRAHGLWTLTLNLQDLEDFEVDYCKDILMQQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KPD7</accession>
    <name>A0A836KPD7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Organic solute transport protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_06975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000017">
        <property type="protein sequence ID" value="KAG5481896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064256.1">
        <property type="nucleotide sequence ID" value="XM_067208882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KPD7"/>
    <dbReference type="GeneID" id="92362816"/>
    <dbReference type="KEGG" id="loi:92362816"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019332">
        <property type="entry name" value="OSCP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21439">
        <property type="entry name" value="OXIDORED-NITRO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21439:SF0">
        <property type="entry name" value="PROTEIN OSCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10188">
        <property type="entry name" value="Oscp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032875613" description="Organic solute transport protein 1" evidence="2">
        <location>
            <begin position="28"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5481896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="446" mass="47323" checksum="5D8FD31E4FFE0107" modified="2021-09-29" version="1">MAMREMPFLILNLGVEMLFVLNSRLHAQSVPPEKATDVLRDVGTNIFDAAFVNELFKPQPMYSSASVAQVFTALASSAVMRLSENSMRKLYDLVYMTVKYLVFTLRHPLELLELTLNHLDAAQLMLPAEVRPLASAAEERVLRLASTLSVGDWASMRQALLNFFSGRHVRVSVFVDNKAQDGESGAFYIPRDAFLSPSPACKPPGLVHVAGSPQPGTFSHSDAHLPYPSHIPLGSWRPQKGAPRMTSNGFDLYAVAVATAPPTSAAAGAVSTVVADPLARQTREIPMPTKLGAVSVGGVNTCANAAALPLLPITNEEEQCAYDAELNFVARLIGSADRARGVRQFELDLFRDDADCAGELAAGVSAPAAGTTSRSSASKSGGATVAPAVPVTRMTASAVKEQNRRLLGIMSDFHSPKGAGSSDAGSTAPASSGKAMNDLLDIMDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KS32</accession>
    <name>A0A836KS32_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Leucine-rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_07606</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000012">
        <property type="protein sequence ID" value="KAG5484836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064948.1">
        <property type="nucleotide sequence ID" value="XM_067209488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KS32"/>
    <dbReference type="GeneID" id="92363422"/>
    <dbReference type="KEGG" id="loi:92363422"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45617">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45617:SF181">
        <property type="entry name" value="LP04042P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
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    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="610"/>
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    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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        <location>
            <begin position="469"/>
            <end position="479"/>
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            <end position="525"/>
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        <location>
            <begin position="579"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5484836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1246" mass="130514" checksum="5438CD1B58A28E2B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KS45</accession>
    <name>A0A836KS45_9TRYP</name>
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        <recommendedName>
            <fullName evidence="4">Tetratricopeptide repeat-containing protein</fullName>
        </recommendedName>
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        <name evidence="2" type="ORF">LSCM4_07654</name>
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        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000012">
        <property type="protein sequence ID" value="KAG5484881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067209533.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="loi:92363467"/>
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    </dbReference>
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        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Hypothetical_protein_-_conserved"/>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
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        <property type="entry name" value="Tfc4/TFIIIC-102/Sfc4"/>
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        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <begin position="1"/>
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        </location>
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        <location>
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            <begin position="1336"/>
            <end position="1360"/>
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            <begin position="805"/>
            <end position="819"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5484881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1360" mass="148969" checksum="FE244D9768EC5444" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KTJ8</accession>
    <name>A0A836KTJ8_9TRYP</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Leishmania</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000008">
        <property type="protein sequence ID" value="KAG5486456.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A836KTJ8"/>
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    <dbReference type="KEGG" id="loi:92363213"/>
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    </feature>
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            <begin position="18"/>
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        </location>
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            <begin position="143"/>
            <end position="155"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5486456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="345" mass="35897" checksum="89C43CC9CB70B988" modified="2021-09-29" version="1">MPSSHKGVHGAAEQAPHKPVKQQRGRQVRPSSPGQAAGKTISASTSASAVATVLAAPQLLKPRRSLRSVTLNPVEPLDLLPKSSAAASWRAQLLRLATQEAHTAATLLRLLPSSAPPSVRDDAQSSRSPLGTATPQPASSGAGATGGAEAQGGQGARRASGHVRHPLPQVALTGTAEAPSPPTQAVQWTSYAELWEGLLARLPCASGDDADGGKRRHDKPAVEQRDSAAPLPAELPGGEAKDGIVCAPAAHLSVMRCALNNDWRSFFLSRVLSASAASSVRVAAPAPRREVAAWAQRCQLKDLVYPPYMTHAEQRAVRRYATASIAAVPSGVQRGLSSVCALDFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KTK3</accession>
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        <recommendedName>
            <fullName evidence="5">Tuzin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_07403</name>
    </gene>
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        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
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            <taxon>Kinetoplastea</taxon>
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            <taxon>Trypanosomatida</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000008">
        <property type="protein sequence ID" value="KAG5486471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="GeneID" id="92363228"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5486471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="631" mass="69842" checksum="CD3086A3F187259A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KUN4</accession>
    <name>A0A836KUN4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_08116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Bates M.D."/>
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            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000015">
        <property type="protein sequence ID" value="KAG5482978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064474.1">
        <property type="nucleotide sequence ID" value="XM_067209091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KYW1"/>
    <dbReference type="SMR" id="A0A836KYW1"/>
    <dbReference type="GeneID" id="92363025"/>
    <dbReference type="KEGG" id="loi:92363025"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF104">
        <property type="entry name" value="CYTOCHROME B5 HEME-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="3">
        <location>
            <begin position="55"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5482978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="163" mass="18230" checksum="9C69ED291CB87A66" modified="2021-09-29" version="1">MLGAPMSSAPEVTRIGIMLGVFLGIVVTLFVHLQFKSRQRLSEKPRSDALVPRAYTVEELALFDGKKRPQAFVGVKGIIYNVSLEWYGPEGPYNAFAGCDSSRQLGKVIVGRDEINADWTTLSPEHLQTLHEWEERLRSKYPVVGWVTDPSKDFVKRAVSLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836L415</accession>
    <name>A0A836L415_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Beta-fructofuranosidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_07482</name>
        <name evidence="9" type="ORF">LSCM4_07486</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">LSCM4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000004">
        <property type="protein sequence ID" value="KAG5487804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFHLR010000004">
        <property type="protein sequence ID" value="KAG5487808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066001.1">
        <property type="nucleotide sequence ID" value="XM_067209369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836L415"/>
    <dbReference type="SMR" id="A0A836L415"/>
    <dbReference type="GeneID" id="92363303"/>
    <dbReference type="KEGG" id="loi:92363303"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18624">
        <property type="entry name" value="GH32_Fruct1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050551">
        <property type="entry name" value="Fructan_Metab_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018053">
        <property type="entry name" value="Glyco_hydro_32_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31953">
        <property type="entry name" value="BETA-FRUCTOFURANOSIDASE, INSOLUBLE ISOENZYME CWINV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00609">
        <property type="entry name" value="GLYCOSYL_HYDROL_F32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044663496" description="Beta-fructofuranosidase" evidence="5">
        <location>
            <begin position="29"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 N-terminal" evidence="6">
        <location>
            <begin position="39"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 C-terminal" evidence="7">
        <location>
            <begin position="413"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5487804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5487808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="643" mass="72389" checksum="089F9CC52FD647E3" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FRA4</accession>
    <name>A0A836FRA4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LSCM4_00760</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059484.1">
        <property type="nucleotide sequence ID" value="XM_067202834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836FRA4"/>
    <dbReference type="SMR" id="A0A836FRA4"/>
    <dbReference type="GeneID" id="92356768"/>
    <dbReference type="KEGG" id="loi:92356768"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13985">
        <property type="entry name" value="STKc_GAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967:SF57">
        <property type="entry name" value="AUXILIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ST"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
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    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="39"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
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        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG5467682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="340" mass="38444" checksum="C1C683A624DD4DEE" modified="2021-09-29" version="1">MGNFFSLCPEPVHGLISSYGIGAVSSTHPAGVVVKGSDYSAVKLVGEGGYAFVYEGYNNATGQRVALKRYVFREVQQQQEALDEITIHRDVCPNDFIVTYLDSEVLYRNGAPLPEMWVVMEFCDGPSLQEYINNRLQSPQPFSVREVFEIVDNIVHAIGHLHSQSPPVSHWDIKPDNFLFTDTGRLKLCDFGSATRHFYAPKSPEEVSVAESELGSRMTLLYRPPESLDLWSKDPVDTKADIWALGVIIYVLVFREMPFEANPMDVMAAVPKRYKGKTEDRCPEEFRPLMNIVRTKMLTKKPADRADIFRISEDLESITHLPPLSRPRPGFQSAQRPRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FZS0</accession>
    <name>A0A836FZS0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_00389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067202471.1"/>
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    <dbReference type="KEGG" id="loi:92356405"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="29"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5464941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="103" mass="11817" checksum="2FEB5EAECF506A9A" modified="2021-09-29" version="1">MQQSLIPGHNNNRHLTYDEVENNIGGLPVTDNRIQDLFDSLDVDHTGMVPVEVVKRFYMGLEHYGVDLSDKEIDATVRKYATTHDDSLNYEEFACFVLSLAQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G1U4</accession>
    <name>A0A836G1U4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_01406</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059151.1">
        <property type="nucleotide sequence ID" value="XM_067203460.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="92357394"/>
    <dbReference type="KEGG" id="loi:92357394"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP-dep_AA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43585:SF2">
        <property type="entry name" value="ATP-GRASP ENZYME FSQD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43585">
        <property type="entry name" value="FUMIPYRROLE BIOSYNTHESIS PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
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    </dbReference>
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        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="5">
        <location>
            <begin position="141"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5466261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="526" mass="56986" checksum="45A4909947E55BA2" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G7N3</accession>
    <name>A0A836G7N3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Adenosine kinase</fullName>
            <shortName evidence="11">AK</shortName>
            <ecNumber evidence="4 11">2.7.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Adenosine 5'-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LSCM4_01086</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>adenosine + ATP = AMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20824"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenosine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.20" evidence="4 11"/>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059801.1">
        <property type="nucleotide sequence ID" value="XM_067203151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G7N3"/>
    <dbReference type="SMR" id="A0A836G7N3"/>
    <dbReference type="GeneID" id="92357085"/>
    <dbReference type="KEGG" id="loi:92357085"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00659"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004001">
        <property type="term" value="F:adenosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01168">
        <property type="entry name" value="adenosine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001805">
        <property type="entry name" value="Adenokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769:SF3">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00989">
        <property type="entry name" value="ADENOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 11" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="12">
        <location>
            <begin position="66"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="12">
        <location>
            <begin position="278"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00012119"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
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        <source>
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        </source>
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            <dbReference type="ARBA" id="ARBA00022777"/>
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            <dbReference type="ARBA" id="ARBA00022840"/>
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            <dbReference type="PIRSR" id="PIRSR601805-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368116"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5467999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="388" mass="41632" checksum="BCDCD85B6426DF46" modified="2021-09-29" version="1">MGMEMLSSGASLAPVSIVCFGHPLLDMMATVDEVFLREYNIESGSVTLATPEQLVLFSKLLDEFEGRVDFVPGGAAMNTARALTWVLPDAHISYVGALGKDRFAEILKGALTSASVEQLFEECDDKPTGTCAGLVLNKDRTLLANLGAAVALSTKHMETEAVQSAIEKASLYYSEGFFLNTASSPHNLLSVAEHAHTRGKLFCFNLHAPYISIAFQSHLQLLLPHVDILFGSDADLLTYASVRWPHDFDMSTLGSVMRANSPRQAALVRCLARLSMLPSVTTGRPRLVVVTCGSHDTYVARGDHVRSYPVPPMAQEEMIDVNGAGDAFVAGFLAQYIVSGDESASVVVGHASAQNCIRHNGAVVSGVPPQLTRRISVTTEPFKGVHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GCQ8</accession>
    <name>A0A836GCQ8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCAAT-binding factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_00188</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058378.1">
        <property type="nucleotide sequence ID" value="XM_067202277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GCQ8"/>
    <dbReference type="SMR" id="A0A836GCQ8"/>
    <dbReference type="GeneID" id="92356211"/>
    <dbReference type="KEGG" id="loi:92356211"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016903">
        <property type="entry name" value="Nucleolar_cplx-assoc_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14428">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14428:SF5">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="341"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="306"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="386"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="197"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="314"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5464747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="636" mass="70456" checksum="736395B2FADBD226" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GFA1</accession>
    <name>A0A836GFA1_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_01547</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059287.1">
        <property type="nucleotide sequence ID" value="XM_067203596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GFA1"/>
    <dbReference type="SMR" id="A0A836GFA1"/>
    <dbReference type="GeneID" id="92357530"/>
    <dbReference type="KEGG" id="loi:92357530"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="680"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="110"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="171"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5466397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="746" mass="80509" checksum="8435202570EB29CC" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GG94</accession>
    <name>A0A836GG94_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_00141</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058331.1">
        <property type="nucleotide sequence ID" value="XM_067202230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GG94"/>
    <dbReference type="GeneID" id="92356164"/>
    <dbReference type="KEGG" id="loi:92356164"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5464700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="184" mass="20569" checksum="428FDFEAFCBD02C0" modified="2021-09-29" version="1">MYCATAVNGVPSDGTLTQDPRLYRSSFVPAESTNWPLTVQTLLCAEMEARTRLVCDALTSFQRIVSLCVAERHGRWAMSLADDESLNGWSCPKCGCAKEDAVTLSSQRQARPPAEVSGGTLLRESCHPPLCDEREMQGQWERCCHYANDAAMRLDRRYLFQQEYGSLVQRIKSASQGIQESVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GGX1</accession>
    <name>A0A836GGX1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_04003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061932.1">
        <property type="nucleotide sequence ID" value="XM_067205995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GGX1"/>
    <dbReference type="SMR" id="A0A836GGX1"/>
    <dbReference type="GeneID" id="92359929"/>
    <dbReference type="KEGG" id="loi:92359929"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5474826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="33613" checksum="51431ED68A572AC7" modified="2021-09-29" version="1">MVLEDYLGDSRSELGSLDDFYRNAKENGRLSEVVFMLNYKDPLVLQQIIYRVESTLTNSHSSPSQVVEVYNSISRTLSATIQPLAQAHGITVYYTSTLFHPAVARLGSLQSLWFAVGIGLAVTLVFFLVYYVGLTTAVAATMVAAIVCFGSLTVCTIFDGEVDAVLQVCSSCTVPISVQYVVHFCSGYFDYLQTTTSNLFAREVTRRGAVRGALLRSAPAVCTSAVCVIVVSIMFAVSSLVPLRRAGQVCITLHLLVLFAGVLFTGAVAALGPMTAYQHWTISTAICMVCAVLIMCCVNGVLGPHGSMILTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GGX5</accession>
    <name>A0A836GGX5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial</fullName>
            <ecNumber evidence="4">2.1.1.201</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ubiquinone biosynthesis methyltransferase COQ5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_00572</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol + S-adenosyl-L-methionine = a 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diol + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10858"/>
            <dbReference type="Rhea" id="RHEA-COMP:10859"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:84166"/>
            <dbReference type="ChEBI" id="CHEBI:84167"/>
            <dbReference type="EC" id="2.1.1.201"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of a multi-subunit COQ enzyme complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion inner membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.201" evidence="4"/>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058751.1">
        <property type="nucleotide sequence ID" value="XM_067202650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GGX5"/>
    <dbReference type="SMR" id="A0A836GGX5"/>
    <dbReference type="GeneID" id="92356584"/>
    <dbReference type="KEGG" id="loi:92356584"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008425">
        <property type="term" value="F:2-methoxy-6-polyprenyl-1,4-benzoquinol methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01813">
        <property type="entry name" value="MenG_UbiE_methyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004033">
        <property type="entry name" value="UbiE/COQ5_MeTrFase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023576">
        <property type="entry name" value="UbiE/COQ5_MeTrFase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01934">
        <property type="entry name" value="MenG_MenH_UbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51608">
        <property type="entry name" value="SAM_MT_UBIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01183">
        <property type="entry name" value="UBIE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01184">
        <property type="entry name" value="UBIE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5465120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="288" mass="32031" checksum="4095F209E14D43FB" modified="2021-09-29" version="1">MLHYTRLGRNMGLGDAYVKKVFDSVASKYDMMNDVLSLGIHRIWKKHLVDDCVCPFAGGKFLDVAGGTGDIAFRITDNIRAREQPFGLVPKALDGTKVVVCDINAMMLKEGQKRAEREGYMDIDWVCASGEELPFEEGVFDGYTVSFGIRNFSDRPKALREAFRVLKVGGAMNVLEFSKVTCPLLRVPYELWSYSFMPQAGRILADEESYRYLVDSIRAFPNQEDFAQMIRDAGFGYVRYENLTGGIACIHTAVKTTPTPVTIKTSCEIAAPKSPELPPKSKPEPSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GGY2</accession>
    <name>A0A836GGY2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Adiponectin receptor protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_00587</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058766.1">
        <property type="nucleotide sequence ID" value="XM_067202665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GGY2"/>
    <dbReference type="SMR" id="A0A836GGY2"/>
    <dbReference type="GeneID" id="92356599"/>
    <dbReference type="KEGG" id="loi:92356599"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF52">
        <property type="entry name" value="ADIPONECTIN RECEPTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="331"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
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        <location>
            <position position="335"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5465135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="362" mass="40799" checksum="B1ABC3826D411C95" modified="2021-09-29" version="1">MVSRKSSKSALKTRSPRRPRAKAPTSPKEGPASGASVSANLTQEKVWHARKKANCEHAKPYNDDATLPLYVIADVPTYLRDNRYILRGYRAYYTGKQCFTSLLRMHNETINIWTHLLGVIVFVALMVQLFTRHIIPEYIAGNVFHQENRTAQPVPVDDARTAWPFIIFGAFSLACVMCMLCSACFHTFLCHMNEDLYHRMHALDYYAITLLVVGSFLPFCFYAMSCAPAWRNAYLSMICSFGAVGLIGPFFRHWTSEAFATKKIIFYVCMVGSGLIPTIHLSKMIPLDISGPYVKGLLLMLVLYGVGVFIYAFRIPEALSPGTFDFYFSSHQIWHVCVLGAAVTHFYNCAAMYVNRGTIVCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GIX7</accession>
    <name>A0A836GIX7_9TRYP</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_03742</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061675.1">
        <property type="nucleotide sequence ID" value="XM_067205738.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="92359672"/>
    <dbReference type="KEGG" id="loi:92359672"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5474569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="529" mass="59570" checksum="E472FDC06EDBFBCE" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GJV6</accession>
    <name>A0A836GJV6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_00651</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058829.1">
        <property type="nucleotide sequence ID" value="XM_067202728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GJV6"/>
    <dbReference type="SMR" id="A0A836GJV6"/>
    <dbReference type="GeneID" id="92356662"/>
    <dbReference type="KEGG" id="loi:92356662"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF59">
        <property type="entry name" value="EF-HAND SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="21"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="131"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5465198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="165" mass="18760" checksum="C093817D620099F2" modified="2021-09-29" version="1">MINTAFSTADGCRLTRDLTDQQKRDIEEAFRVLDVKGVNTVTPNDLKVALRALGYEPDKDAVRKLVAEMDRGGVSSNLVLSEFEAVMRQRFFAEDNDDEVDLAFPLFTEGKSEFISLDDLKRVAAEVGEDIPEDVLQELIRECDVLDRDDRISREEFKKILKSDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GLL2</accession>
    <name>A0A836GLL2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">adenine phosphoribosyltransferase</fullName>
            <ecNumber evidence="6">2.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_04995</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="6"/>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062272.1">
        <property type="nucleotide sequence ID" value="XM_067206969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GLL2"/>
    <dbReference type="SMR" id="A0A836GLL2"/>
    <dbReference type="GeneID" id="92360903"/>
    <dbReference type="KEGG" id="loi:92360903"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050120">
        <property type="entry name" value="Adenine_PRTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11776">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11776:SF7">
        <property type="entry name" value="PHOSPHORIBOSYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="11">
        <location>
            <begin position="49"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5476039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="221" mass="24225" checksum="6C0AE9DD2A7051FA" modified="2021-09-29" version="1">MARRDLVEVDPHHYTLDPKHPLSKALVDAAQFTTPPSAPLTKIPRLYDVSTITEKPALFTRVLHFLAERYRAMGAQGPTHVLAIEARGCILGAPLALLLDLPFVPMRRDNISESAFVTEGDDKPPAQPIAVRNNSIDAASRVVIVDDFISSGRTMDSAMDCAVVAGSTIVEAVAVCDTFASGGVVSIHKEKRFEDTNVLTLFRLRSKLDVLSYKRCIRSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GLR4</accession>
    <name>A0A836GLR4_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_01285</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059033.1">
        <property type="nucleotide sequence ID" value="XM_067203342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GLR4"/>
    <dbReference type="GeneID" id="92357276"/>
    <dbReference type="KEGG" id="loi:92357276"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011893">
        <property type="entry name" value="Selenoprotein_Rdx-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019389">
        <property type="entry name" value="Selenoprotein_T"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13544">
        <property type="entry name" value="SELENOPROTEIN T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13544:SF0">
        <property type="entry name" value="THIOREDOXIN REDUCTASE-LIKE SELENOPROTEIN T"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rdx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="187"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="188"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5466143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="381" mass="41109" checksum="DB6F053A332F2B74" modified="2021-09-29" version="1">MASVLPLALLSQGCGISYARAVLLALASFVLVALLFSGGYQGGSRGNSLSIAGHPRWSGIVLPAMATADGGFSVEPAEFHASEAGKALPMNEQYDYRDEAEAEAVASKAAATAGASAKSPTAHLDRLSFEELKTLLSEKKKGWVNLDRFKDREALIRAILDMEHKEAVQAAFRTEVAAAARWYAAQRSQRKRTHPRLRGSRARSDGAEPAAAGDSEGDQAQYNLLILYNEANGYRSKFEELRKELQESEALSLPNLADFSIIGQAYPMSSDRVLISKALQGAFFATLGLALMADQLKFIPESARGALRQRRGLIISTGFLLNVLSRAALQNSAFEVFLDGELIYSGLDAGGRLPTAELLSNQLLERTLLRDYHAATMAAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GLY1</accession>
    <name>A0A836GLY1_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059757.1">
        <property type="nucleotide sequence ID" value="XM_067203107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GLY1"/>
    <dbReference type="GeneID" id="92357041"/>
    <dbReference type="KEGG" id="loi:92357041"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="375"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5467955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="398" mass="43854" checksum="736FB1F664F742DA" modified="2021-09-29" version="1">MEFSPGDTTAQRPAVGVPPYRAPPLSGLYLMRYHPPTSGDALSDYLPREFCGEAAGGPTANLVEQSGAFSAEARHAAVHTQLLGASSLNDGDIDLFALYSVCDVEPVPCLRCSLHMQATLNTCSYRLRQWYHLQRNDAESFKPGPVADLETYDEVHARSKAGTSPLIRTLQKGWYVFFFPISECGRLKDNLLVYVGDALIAGDVAECDLANDGLLRPLKTAATAAASKATSTNPRRWKSLFYYVISPVPVRCGGRESTGVHFTVSWCNSPAGAPLQRWKKSLTLLYSYYCSPRAPDIFTCHAQFPSDTRLRLVRSPNCDAKVRLRSDVSEHAANVGVETIDGKPLEEHRHTSDYTFVLQFLFGDSQGILEETSTFAAAVVSTVFLLIMWLFLTKDLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GM51</accession>
    <name>A0A836GM51_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059258.1">
        <property type="nucleotide sequence ID" value="XM_067203567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GM51"/>
    <dbReference type="SMR" id="A0A836GM51"/>
    <dbReference type="GeneID" id="92357501"/>
    <dbReference type="KEGG" id="loi:92357501"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5466368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="177" mass="19905" checksum="87AAA10A2FB5B59F" modified="2021-09-29" version="1">MATEGEEEEWADGVDDFFAEFSLAALQDKSKRRKNAEVYQASVAQSKKKLERKEADRSESAEEARRRITAAVMSRATAKEIERAVQNAKKHQKTTQAKSSSSPRSVNLGLSFSLPEQPHGSPAPASSSPSLTGHDSTTHRFHAESSSYRFCKKRQRVDSKFARKAARKERAKEHRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GNP3</accession>
    <name>A0A836GNP3_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_02307</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5468915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059892.1">
        <property type="nucleotide sequence ID" value="XM_067204340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GNP3"/>
    <dbReference type="GeneID" id="92358274"/>
    <dbReference type="KEGG" id="loi:92358274"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5468915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="193" mass="21939" checksum="103AE1A7BC627DD3" modified="2021-09-29" version="1">MIQTARILLRTRPPLLLADTQTAITDAHVVYQLVDFAYSLGLVSPTWMSYEFSLVSRLKLRRGTVPVNVWHTMCNRTFFEAYATHALSKIDRSELQKAAPLPVIQFTLKQDQAQQLKWEPACPSVALCFRSPARRSHMHQLWVLTELASKIPVKVSARVETPPFATFVHVEQLCPDENLSRLLLKAWGGKKCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GNQ3</accession>
    <name>A0A836GNQ3_9TRYP</name>
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        <recommendedName>
            <fullName evidence="6">Ankyrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_02323</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5468930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059907.1">
        <property type="nucleotide sequence ID" value="XM_067204355.1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
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    </dbReference>
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    </dbReference>
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            <begin position="128"/>
            <end position="160"/>
        </location>
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        <source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="408" mass="44632" checksum="E61D90D5D79D4408" modified="2021-09-29" version="1">MSNAVKPPAASSAPAYKLPQRDLFDLVATNDVASLLILVRGDNPFDVSPGMELIRYKMSLRRVADMVRAENANLEANAVPQVDTAQIPRTRDASGNSAVHVAASLGYSSMIEILVSECGCAVDTYNASGLTPSHLAALHGHVDCIRLLRDLGASLLSPTHWDPLCTAGCHRGFCGRTTLFLAHCKQQAAVVAFLLPVYREFINTNFCGETGAEVWKTVAMEQNVKSLSLLLDALECRATVNGALPVSIDFDVEDALREALPALLETILPSSRQMTSQQLFLFKRLVELGYVVSATVLCSSNTVLERVLNTAHVQAWRALVEQGLVQPHQCCLDAVHSSEHGSKSEAELRALIEEAKAHFRYQIAKKSYMEKGDSDRRRHTLLSRRSVWKKASDDLKQLSLSPARCPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836GNS5_9TRYP</name>
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        <recommendedName>
            <fullName evidence="5">Ribosomal protein S9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_04764</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Discoba</taxon>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000023">
        <property type="protein sequence ID" value="KAG5478531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063192.1">
        <property type="nucleotide sequence ID" value="XM_067206745.1"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A836GNS5"/>
    <dbReference type="GeneID" id="92360679"/>
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    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5478531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="441" mass="49802" checksum="3B1F5345BE106B93" modified="2021-09-29" version="1">MKQLLSPRTARHARLFRLANSLAGQRGVPESDGERLSWVNSHIKRAQDMELSREEEALRERMMPLEVGDNAVVSNNQATHGNLFHFREYPMYPGEYVPAGHNTLSSLKDELRSDLTAQSLKEAWMRVSGGMYFKSIDDYYASVDGLDQEQLGEIVSALLPDLRKYEAQALVTKVLESLSKPADTPSRQLSRTITADAVGLDNAPGHYTNFLEWMGRMTETKAFKTEHALFEFSRRKFNREDVRVMFENYNLMSKATLDADSADSYSHFYTVLRDFSRKVAGEDTRHQIGVRIDPAEVDPETGIAVGHGRADGQKYMFTALIRENRDHNGSVTLLGKPLSVAFNDKSWLMEMVLMPFDEAKLDFHDFDVNIISEGKAMPSLANEIAAFACRMAVANAITKLLPLARIPLKKSGLLSVDRRREPGQFPGYVDGKKNKRKFAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GR86</accession>
    <name>A0A836GR86_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063562.1">
        <property type="nucleotide sequence ID" value="XM_067207789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GR86"/>
    <dbReference type="GeneID" id="92361723"/>
    <dbReference type="KEGG" id="loi:92361723"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="736"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="352"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="760"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5479851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="849" mass="92860" checksum="71423FDC8C9A260F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GS02</accession>
    <name>A0A836GS02_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061288.1">
        <property type="nucleotide sequence ID" value="XM_067204251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GS02"/>
    <dbReference type="GeneID" id="92358185"/>
    <dbReference type="KEGG" id="loi:92358185"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032966081" evidence="1">
        <location>
            <begin position="30"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5472892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="338" mass="36205" checksum="EA68866AA881A59C" modified="2021-09-29" version="1">MTPRCVPQVLAVFCLTAALALLCCETAQAQANCGSIALCKPYEKMGPACARNKRMNLRFVLQTARENNFTVGAEVHHVTTYGFCPVVDQLSSFTLTGAPFLATSYTKNDTSGKVTNHLSLGMTPRYLSVYGFGASNSTHFPEKGVSRGTVLVAINGSDFTGVVNSVGVVTMLSLEIGLNNGLFNYIGASKASKRAVVNPNYNASLCSNGSESSGSVNYCEKEIFMPVAAKVVQPAKVGFIPTCDAKDICTVGNPRIYTCIGDIPGQKNCGVFRSDPEEIRDLRMTVLVSYYGTDSRRNVLTSGGKNPLNFVSFVKTNALYAIGDRISSLFTGNLSVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GS75</accession>
    <name>A0A836GS75_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_01747</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000022">
        <property type="protein sequence ID" value="KAG5479159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063252.1">
        <property type="nucleotide sequence ID" value="XM_067203793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GS75"/>
    <dbReference type="GeneID" id="92357727"/>
    <dbReference type="KEGG" id="loi:92357727"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5479159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="145" mass="15811" checksum="61316565F007CB66" modified="2021-09-29" version="1">MADIKSPPGPAVVVVDCKEVGVTINLHSPPTASNFLAYNRVCATLDSDYLMQPINEAQYDSETQACVDRISNGPTSFYDHYVRKPTRKRGLPVGCECPMEHTGVNEDLLMPPTQRDLPASGLGAGAFSDPLTRRLATGRMPPCYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GT46</accession>
    <name>A0A836GT46_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5-histidylcysteine sulfoxide synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_03545</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; ergothioneine biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061480.1">
        <property type="nucleotide sequence ID" value="XM_067205543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GT46"/>
    <dbReference type="SMR" id="A0A836GT46"/>
    <dbReference type="GeneID" id="92359477"/>
    <dbReference type="KEGG" id="loi:92359477"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120147">
        <property type="term" value="F:formylglycine-generating oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000787">
        <property type="entry name" value="Generic methyltransferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1580.10:FF:000006">
        <property type="entry name" value="Generic methyltransferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="entry name" value="paralog of FGE (formylglycine-generating enzyme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027625">
        <property type="entry name" value="OvoA_Cterm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027577">
        <property type="entry name" value="OvoA_Nterm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051043">
        <property type="entry name" value="Sulfatase_Mod_Factor_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04345">
        <property type="entry name" value="ovoA_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04344">
        <property type="entry name" value="ovoA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23150:SF26">
        <property type="entry name" value="GENERIC METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23150">
        <property type="entry name" value="SULFATASE MODIFYING FACTOR 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DinB-like" evidence="5">
        <location>
            <begin position="55"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase-modifying factor enzyme-like" evidence="4">
        <location>
            <begin position="229"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5473477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="757" mass="87006" checksum="9A08EB894BDD8BAA" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GTG7</accession>
    <name>A0A836GTG7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DEX1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_03102</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">LSCM4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060672.1">
        <property type="nucleotide sequence ID" value="XM_067205120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GTG7"/>
    <dbReference type="GeneID" id="92359054"/>
    <dbReference type="KEGG" id="loi:92359054"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056376">
        <property type="entry name" value="DEX1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045232">
        <property type="entry name" value="FAM234"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21419">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21419:SF23">
        <property type="entry name" value="PROTEIN DEFECTIVE IN EXINE FORMATION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23722">
        <property type="entry name" value="Beta-sand_DEX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032896173" description="DEX1 C-terminal domain-containing protein" evidence="5">
        <location>
            <begin position="21"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="domain" description="DEX1 C-terminal" evidence="6">
        <location>
            <begin position="642"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
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            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045243">
        <property type="entry name" value="Rna14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980:SF0">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980">
        <property type="entry name" value="RNA CLEAVAGE STIMULATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="874"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="883"/>
            <end position="894"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5470388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="989" mass="111501" checksum="15DEB6C032249A33" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GV83</accession>
    <name>A0A836GV83_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nucleoside transporter 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_00199</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058389.1">
        <property type="nucleotide sequence ID" value="XM_067202288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GV83"/>
    <dbReference type="SMR" id="A0A836GV83"/>
    <dbReference type="GeneID" id="92356222"/>
    <dbReference type="KEGG" id="loi:92356222"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002259">
        <property type="entry name" value="Eqnu_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332:SF82">
        <property type="entry name" value="TRANSPORTER 2, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01733">
        <property type="entry name" value="Nucleoside_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="440"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="475"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5464758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="503" mass="54823" checksum="0DB499347E128E4F" modified="2021-09-29" version="1">MVKMTEQSAAAAEGHRPLPWYRMGFHTFAEFNTYLTFVLLGMSIMMVTSAITSAPDFVSKYYIYATGNPDAVAEAPMFWRNANTFYNAGTYAVQVITEIASLTPLVRSIPLGFRLFLGLGIPLVELLLIIIVPAATIPTQGGAIAVIMVVALMGGFSKALCDSCTNALVGPFPTKFMNGAQWGLSVIALLMSIIQIILKVSMGSTYQDVLTISRIYFGIGIAIQLLAIVELFLLRYNPFAQKYIAEFRAAALRRRGDMGLERSQESNEPATGDVAEVVSKLENKEGPLYELDETDEVRAVSSAAFAVENANVLQATGDADKMVDLDQTDNITSTEQMLRVSVWSVARRIYPMLLCAFTIFFTSLLLFPGVFFMVPVNSDWYMTIVVTLFNAGDFISRLILMVRMLRPSPKLVIAGTLGRLGVVPLLVLCVRGLIPGAALPYILIFVVGLTNGYFGTMSCIHCPRTPTLHYAGERSLAAMLSGIALMLGLCFGSNLSLAITLTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GVH2</accession>
    <name>A0A836GVH2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_01955</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061031.1">
        <property type="nucleotide sequence ID" value="XM_067203994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GVH2"/>
    <dbReference type="SMR" id="A0A836GVH2"/>
    <dbReference type="GeneID" id="92357928"/>
    <dbReference type="KEGG" id="loi:92357928"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00106">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF75">
        <property type="entry name" value="CENTROMERE-ASSOCIATED PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4 5 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="8">
        <location>
            <begin position="14"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="387"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="100"/>
            <end position="107"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5472635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="611" mass="67670" checksum="C0FF9BEE50E55C0D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GXF6</accession>
    <name>A0A836GXF6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ethanolamine kinase</fullName>
            <ecNumber evidence="3">2.7.1.82</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_04219</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the choline/ethanolamine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.82" evidence="3"/>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062145.1">
        <property type="nucleotide sequence ID" value="XM_067206208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GXF6"/>
    <dbReference type="GeneID" id="92360142"/>
    <dbReference type="KEGG" id="loi:92360142"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004305">
        <property type="term" value="F:ethanolamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603">
        <property type="entry name" value="CHOLINE/ETHANOALAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603:SF66">
        <property type="entry name" value="ETHANOLAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="98"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5475637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="641" mass="71738" checksum="99BC4BB2C98C4336" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GY69</accession>
    <name>A0A836GY69_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RanBP2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_01559</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059298.1">
        <property type="nucleotide sequence ID" value="XM_067203607.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92357541"/>
    <dbReference type="KEGG" id="loi:92357541"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032923265" description="RanBP2-type domain-containing protein" evidence="4">
        <location>
            <begin position="22"/>
            <end position="1581"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="5">
        <location>
            <begin position="1347"/>
            <end position="1366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5466408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1581" mass="170395" checksum="9B845382A5EE5938" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GYX5</accession>
    <name>A0A836GYX5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nucleolar protein 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_00774</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059498.1">
        <property type="nucleotide sequence ID" value="XM_067202848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GYX5"/>
    <dbReference type="SMR" id="A0A836GYX5"/>
    <dbReference type="GeneID" id="92356782"/>
    <dbReference type="KEGG" id="loi:92356782"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019186">
        <property type="entry name" value="Nucleolar_protein_12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14577">
        <property type="entry name" value="NUCLEOLAR PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14577:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09805">
        <property type="entry name" value="Nop25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="72"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="113"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="268"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="85"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="291"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5467696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="35735" checksum="5555097079D8FF6E" modified="2021-09-29" version="1">MTKYVDAGAKIKTRKGFKSDRLENYRRMLAKKNGKKVSDAPTRTARPKSVTFDDSSRRDYLLTLHKKKNERRVQAFVDAKRKQRKDSAKTRREQREEARRAYNSYARVPILPDYTYRLPKPQDDGFDDHEEAEEIGEESGHSPQGEPEVDDSEAAANSAGDIMEAESSQKRRRAKRLATLPLTEHAMPGDMLDQEASADADTRRSAGPSSSCKVDSEYVTVEVKPLFGISSGDATSTRKEGVASSKALPSNNFDDLPLVVQQELRRLRQETKGPAKTKPRVHMMKELEKIRKIRKHSRKGHGKRKASGKRKNRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GZC7</accession>
    <name>A0A836GZC7_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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            <end position="366"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="EMBL" id="KAG5474720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="737" mass="81417" checksum="A2ED5908E340305A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836GZW6_9TRYP</name>
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        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="5" type="ORF">LSCM4_02051</name>
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    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
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    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472728.1"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H3D3</accession>
    <name>A0A836H3D3_9TRYP</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name evidence="1" type="ORF">LSCM4_06845</name>
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    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Leishmania</taxon>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000009">
        <property type="protein sequence ID" value="KAG5486136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_067208756.1"/>
    </dbReference>
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        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5486136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1639" mass="185097" checksum="FD6592CC447234AA" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H5N9</accession>
    <name>A0A836H5N9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dynein assembly factor 3, axonemal</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_04130</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNAAF3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062056.1">
        <property type="nucleotide sequence ID" value="XM_067206119.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="92360053"/>
    <dbReference type="KEGG" id="loi:92360053"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070286">
        <property type="term" value="P:axonemal dynein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044458">
        <property type="term" value="P:motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039304">
        <property type="entry name" value="DNAAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028235">
        <property type="entry name" value="DNAAF3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027974">
        <property type="entry name" value="DUF4470"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22118">
        <property type="entry name" value="DYNEIN ASSEMBLY FACTOR 3, AXONEMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22118:SF14">
        <property type="entry name" value="DYNEIN AXONEMAL ASSEMBLY FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14737">
        <property type="entry name" value="DUF4470"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14740">
        <property type="entry name" value="DUF4471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4470" evidence="6">
        <location>
            <begin position="136"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein assembly factor 3 C-terminal" evidence="7">
        <location>
            <begin position="254"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="96"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5475548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="597" mass="66411" checksum="72DD996E1CF04071" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H6P7</accession>
    <name>A0A836H6P7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bms1-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_06304</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. TSR1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000007">
        <property type="protein sequence ID" value="KAG5486839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065633.1">
        <property type="nucleotide sequence ID" value="XM_067208228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H6P7"/>
    <dbReference type="SMR" id="A0A836H6P7"/>
    <dbReference type="GeneID" id="92362162"/>
    <dbReference type="KEGG" id="loi:92362162"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012948">
        <property type="entry name" value="AARP2CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030387">
        <property type="entry name" value="G_Bms1/Tsr1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858:SF1">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN TSR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08142">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04950">
        <property type="entry name" value="RIBIOP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00785">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01362">
        <property type="entry name" value="DUF663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51714">
        <property type="entry name" value="G_BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Bms1-type G" evidence="6">
        <location>
            <begin position="72"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5486839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="780" mass="88230" checksum="6DD670B8EC797725" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H8E1</accession>
    <name>A0A836H8E1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_07154</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000018">
        <property type="protein sequence ID" value="KAG5481442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064121.1">
        <property type="nucleotide sequence ID" value="XM_067209058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H8E1"/>
    <dbReference type="SMR" id="A0A836H8E1"/>
    <dbReference type="GeneID" id="92362992"/>
    <dbReference type="KEGG" id="loi:92362992"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5481442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="427" mass="45538" checksum="DE4401BA1128D10B" modified="2021-09-29" version="1">MEAAALAASRPRNEDTVSAVDSRDDVVAFVVGSGQHTMYFSKSALMRHAPFFRAYFTEHAAQAAETGGSECGGSIVVLRHVRPRSAEAALRLCHSAHHADDKLFWSLQRECEKADAAHQPEALRAVLSLYSACVTFELHAHAQTIGVTVASVVAADTVYDVLKTCARYTTTLLPETQRAVGLDVLLAACNAFVRAPGGQQGERRWHRLFKQYPGLSERVAAASAAPAASAAVAALSSAHGEGNAIAAEASSPSPPRRALLSPRKDAVVAEASAIAIPKATAPLPDVFAEHLRQTEDLALAAQWRCRTMAAEVTALRKDCAALNSTAKRDEAVAAELTLYLGEVRVYLQALRHAEAEMQRLCAAAAALCTAPSLPTSASTLHELRYNIQHASSRTAERKAAVDELIAVEQDALCELDAELARLRGAMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H8N4</accession>
    <name>A0A836H8N4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">P-type ATPase A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_07570</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000004">
        <property type="protein sequence ID" value="KAG5487889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066086.1">
        <property type="nucleotide sequence ID" value="XM_067209454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H8N4"/>
    <dbReference type="SMR" id="A0A836H8N4"/>
    <dbReference type="GeneID" id="92363388"/>
    <dbReference type="KEGG" id="loi:92363388"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
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</entry>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
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            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
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                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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    <sequence length="363" mass="38622" checksum="668C74159D99DD1C" modified="2021-09-29" version="1">MPLPSPSMHWSEGVNGDGAFGGCHPPFSKGSSHINRPLSLDLSSFSSFAVGLPRDMTNGLHAAGTGSSFEWLQPWRTPQDCLQGGLGLLYSMREMLEHAQRARQRSVNELYAVHATEGSAVSTVNSCRCGSSGPPRAGSGGSSSSSSDNAGCPNTPLSLSVRRSSHRALRLMSKCDDADGSAAGCRTSSVGQRSRRGGGEHRVSLLESSPSTGKGSVQEVEPAGAVEEVTPQRVPEASAASVPPVVPVIPRFEEVKRGQELTRQRLQQQLSLHPHPRSDAARRKRRASINSNDDDDGAHSPHHPDGKCDQTARPGDLRHRPGTSLELGFSDSNGDEPPYSPQRRHTASASAQVDNDVGHSRRA</sequence>
</entry>
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                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="protein sequence ID" value="KAG5472843.1"/>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000016">
        <property type="protein sequence ID" value="KAG5482387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067207579.1"/>
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            <begin position="1463"/>
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        </location>
    </feature>
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        <location>
            <begin position="1494"/>
            <end position="1504"/>
        </location>
    </feature>
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        <location>
            <begin position="1730"/>
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        </location>
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        <location>
            <begin position="1755"/>
            <end position="1765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5482387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HA64</accession>
    <name>A0A836HA64_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA ligase</fullName>
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        <name evidence="18" type="ORF">LSCM4_02274</name>
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    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="14"/>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061344.1">
        <property type="nucleotide sequence ID" value="XM_067204307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HA64"/>
    <dbReference type="GeneID" id="92358241"/>
    <dbReference type="KEGG" id="loi:92358241"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07900">
        <property type="entry name" value="Adenylation_DNA_ligase_I_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07969">
        <property type="entry name" value="OBF_DNA_ligase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3260.10:FF:000013">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000062">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000002">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050191">
        <property type="entry name" value="ATP-dep_DNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674:SF4">
        <property type="entry name" value="DNA LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674">
        <property type="entry name" value="DNA LIGASE 1/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00333">
        <property type="entry name" value="DNA_LIGASE_A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="17">
        <location>
            <begin position="504"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG5472948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="768" mass="84941" checksum="565C9902F0E8B8BE" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HB14</accession>
    <name>A0A836HB14_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C-8 sterol isomerase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_03660</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ERG2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061593.1">
        <property type="nucleotide sequence ID" value="XM_067205656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HB14"/>
    <dbReference type="SMR" id="A0A836HB14"/>
    <dbReference type="GeneID" id="92359590"/>
    <dbReference type="KEGG" id="loi:92359590"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006716">
        <property type="entry name" value="ERG2_sigma1_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10868">
        <property type="entry name" value="SIGMA 1-TYPE OPIOID RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10868:SF1">
        <property type="entry name" value="SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04622">
        <property type="entry name" value="ERG2_Sigma1R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5473590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="24671" checksum="CED6652C49D6E100" modified="2021-09-29" version="1">MKSCKSTGVVLTAIVAVVIAFFAYVDQPSNWVYDPVRLQQIAQQSIANANAANEGKATAKQITDETIRLMRENYPQTTRYTGRWLWNNAGGAMGSMTVLHCSFSEYLIIFGTSVGTEGHTGRYFWADDFFNILVGEQWAALPGVEGKEVYRAGDQHVLPRGTAKQYGMPGECWALEYARGNIASMLFFGFADMLTSTLDVVTMYETVRESAGNMLMNTLLGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HBR9</accession>
    <name>A0A836HBR9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LSCM4_03968</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-dependent RNA helicase required for 60S ribosomal subunit synthesis. Involved in efficient pre-rRNA processing, predominantly at site A3, which is necessary for the normal formation of 25S and 5.8S rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061897.1">
        <property type="nucleotide sequence ID" value="XM_067205960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HBR9"/>
    <dbReference type="SMR" id="A0A836HBR9"/>
    <dbReference type="GeneID" id="92359894"/>
    <dbReference type="KEGG" id="loi:92359894"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00268">
        <property type="entry name" value="DEADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000524">
        <property type="entry name" value="ATP-dependent RNA helicase DDX42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001550">
        <property type="entry name" value="DEAD box DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044742">
        <property type="entry name" value="DEAD/DEAH_RhlB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="119"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="332"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="478"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="483"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG5474791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="536" mass="59256" checksum="6AD811DA0A289A0F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HCX6</accession>
    <name>A0A836HCX6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ACB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_06906</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000017">
        <property type="protein sequence ID" value="KAG5481830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064190.1">
        <property type="nucleotide sequence ID" value="XM_067208816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HCX6"/>
    <dbReference type="SMR" id="A0A836HCX6"/>
    <dbReference type="GeneID" id="92362750"/>
    <dbReference type="KEGG" id="loi:92362750"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000010">
        <property type="entry name" value="Acyl-CoA-binding domain-containing protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF115">
        <property type="entry name" value="ACB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="2">
        <location>
            <begin position="2"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5481830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="103" mass="11415" checksum="526B48378474A98D" modified="2021-09-29" version="1">MSAVDFDAAVAYVRSLPADGPVRMDNSTRLSFYSLYKQATEGDVKGTQPWAVQVEARAKWDAWNARKGMSSDDAKAAYVKLLITVLRSRGMVWESAAQVRSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HCZ6</accession>
    <name>A0A836HCZ6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP-dependent RNA helicase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_06937</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000017">
        <property type="protein sequence ID" value="KAG5481860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064220.1">
        <property type="nucleotide sequence ID" value="XM_067208846.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836HCZ6"/>
    <dbReference type="GeneID" id="92362780"/>
    <dbReference type="KEGG" id="loi:92362780"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002950">
        <property type="entry name" value="ATP-dependent RNA helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:001159">
        <property type="entry name" value="Putative ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:001359">
        <property type="entry name" value="Putative ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000313">
        <property type="entry name" value="Putative ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003667">
        <property type="entry name" value="Putative ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003287">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein 200 kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000001">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041094">
        <property type="entry name" value="Brr2_helicase_PWI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF4">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18149">
        <property type="entry name" value="Helicase_PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039073">
        <property type="entry name" value="BRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="493"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="713"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="369"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1403"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1877"/>
            <end position="1907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="371"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="392"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1891"/>
            <end position="1900"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5481860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2361" mass="258671" checksum="3EF9D201F2C73316" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HFT1</accession>
    <name>A0A836HFT1_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062283.1">
        <property type="nucleotide sequence ID" value="XM_067206980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HFT1"/>
    <dbReference type="GeneID" id="92360914"/>
    <dbReference type="KEGG" id="loi:92360914"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5476050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="352" mass="38487" checksum="9513943423167675" modified="2021-09-29" version="1">MQTESADKLSLAEASFQLLEEAYERQWIRARLTCEAQTSRADAHVVASASSAAEQMCRLWGDTVRLHRRFVEVTEHKGPGFTQEERASLRLLGFRSPSPPLSDVALSRPEPPLPSSPCRAAPTHASSQGEDSVALRKECARLRHDYAQLLSTLAWYKLCERHAHGLGSDKTLSSPSKATSTSISDAYAELAEVQHRYRSLLCPTAAEYHLNPSDGSQRAEDVAIAQLLLDCAFPPQVRVARLGLDGLFMVDRPVFIGFASPQSAMLVVRDPDGLEDDCKLETYLTVVFAPLLRAVQWRKPSVRVPVGGSSATAGPQVRSFRAMPAVSSRIPHTVRRESASSTRDPALSALTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HHP4</accession>
    <name>A0A836HHP4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Basal body-orientation factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_05460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5478061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062968.1">
        <property type="nucleotide sequence ID" value="XM_067207400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HHP4"/>
    <dbReference type="SMR" id="A0A836HHP4"/>
    <dbReference type="GeneID" id="92361334"/>
    <dbReference type="KEGG" id="loi:92361334"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14845:SF6">
        <property type="entry name" value="BASAL BODY-ORIENTATION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14845">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING 166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="451"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="106"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="205"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="370"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5478061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="546" mass="60834" checksum="5E1E86389CBFB74C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HI52</accession>
    <name>A0A836HI52_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_04498</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062691.1">
        <property type="nucleotide sequence ID" value="XM_067206482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HI52"/>
    <dbReference type="GeneID" id="92360416"/>
    <dbReference type="KEGG" id="loi:92360416"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5477280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="263" mass="29093" checksum="B2501FA9B4BB3E5F" modified="2021-09-29" version="1">MMTAISPFLSLVDMYDYLPNFDADCDLQVGDWVVVQPRRMAALLGPLISTWETVPRAHALSATSSFAPRYALSQLLPEPLTLRRRSLAWNRVGLASFTKLPRLAPLSMARAHYCQRKRMHVADDSPIAERDSSVLDGDASSGNGNLYLHVRLGLLTPSRPYVFGGLDIVEVLGWPSDDACAEEDRGGRVPSSSVTRQPAVLYLNLLTGETLTREEAVRRASKLMPSYTSSTATWSSAIEAAAEKEWQQWVLRRACITQQQPCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HJF1</accession>
    <name>A0A836HJF1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ODAD1 central coiled coil region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_07812</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000006">
        <property type="protein sequence ID" value="KAG5487322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065819.1">
        <property type="nucleotide sequence ID" value="XM_067209689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HJF1"/>
    <dbReference type="GeneID" id="92363623"/>
    <dbReference type="KEGG" id="loi:92363623"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051876">
        <property type="entry name" value="ODA-DC/CCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049258">
        <property type="entry name" value="ODAD1_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21694">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21694:SF18">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21773">
        <property type="entry name" value="ODAD1_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ODAD1 central coiled coil region" evidence="4">
        <location>
            <begin position="201"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="43"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="128"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="311"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5487322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="751" mass="81675" checksum="F91213AC4617D3CD" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HP30</accession>
    <name>A0A836HP30_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_06106</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000020">
        <property type="protein sequence ID" value="KAG5480340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063671.1">
        <property type="nucleotide sequence ID" value="XM_067208031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HP30"/>
    <dbReference type="GeneID" id="92361965"/>
    <dbReference type="KEGG" id="loi:92361965"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5480340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="201" mass="22354" checksum="1511DEF4EBB0358F" modified="2021-09-29" version="1">MLFSPLRAPFFAHSSASQLHSTSPTCGPFHLTVSLFPCPSPFSPFPLRASLSACLRVPVCVTTSSILRCVPAFLPHCPSVHHIALSRSHSLFSTSAYERANTHARAPQTNNRGSGRAMLRRSRVMCGGFSQEAFHRMTKYITSRNPNEKYLRTGHIVLETLKRYHAYILAVALISAFTVYDHRQHPERMPGAAHDGRSLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HQ79</accession>
    <name>A0A836HQ79_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000019">
        <property type="protein sequence ID" value="KAG5480925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063926.1">
        <property type="nucleotide sequence ID" value="XM_067208414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HQ79"/>
    <dbReference type="SMR" id="A0A836HQ79"/>
    <dbReference type="GeneID" id="92362348"/>
    <dbReference type="KEGG" id="loi:92362348"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5480925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="293" mass="33393" checksum="F11E8812566E796A" modified="2021-09-29" version="1">MWHFSSPSRHAGQVVRPAAFTACRVAAGSSCASSSFTASTRTTSAGSALCATHRAKSYRFFMNLDDPDATRRRIEGELDRLASEHKKDTTAYLHSLLNLALSHYQRGDFISARDMADYTHQKALTHNSKSSLLYFTATTCAKCADALANEYEAHLQRRDAQRHTSAALTPEPSVVFSARRTIRKLRADAERYRVIAHRVYHRPDMAFMRGDSDSGDGRWRSSARHAEGRDTRHTWADDSSNNSVDEEYAPHMYGPRWQDRRKRPEHAEMKHFYKQQCGPSPTWRGETRWNVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HQ89</accession>
    <name>A0A836HQ89_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glycerol uptake protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_06511</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000019">
        <property type="protein sequence ID" value="KAG5480940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063941.1">
        <property type="nucleotide sequence ID" value="XM_067208429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HQ89"/>
    <dbReference type="GeneID" id="92362363"/>
    <dbReference type="KEGG" id="loi:92362363"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051085">
        <property type="entry name" value="MB_O-acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285:SF18">
        <property type="entry name" value="PROTEIN-CYSTEINE N-PALMITOYLTRANSFERASE RASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="474"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="570"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="654"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="709"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="605"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="613"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5480940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="746" mass="84736" checksum="EC29C991B5C682AB" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HWS0</accession>
    <name>A0A836HWS0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RanBP2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_06669</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000010">
        <property type="protein sequence ID" value="KAG5485711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065295.1">
        <property type="nucleotide sequence ID" value="XM_067208584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HWS0"/>
    <dbReference type="SMR" id="A0A836HWS0"/>
    <dbReference type="GeneID" id="92362518"/>
    <dbReference type="KEGG" id="loi:92362518"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23111:SF40">
        <property type="entry name" value="RNA-BINDING PROTEIN INVOLVED IN HETEROCHROMATIN ASSEMBLY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23111">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00641">
        <property type="entry name" value="Zn_ribbon_RanBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="5">
        <location>
            <begin position="152"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5485711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="189" mass="20711" checksum="EBB50D2FE2117398" modified="2021-09-29" version="1">MFRGYGRPGARYLRRLCGADAAAVAQPATIGSATNMAMTSSVASTYVRSFSTATPLCLARRLGGGHRRQRSREPTKGDWLCQCGEVNYRSKRECYKCGAPAPPLPPGVRRPSLPGEDPHDWACPCGQMNFRGSVVCHKCQQPKPIPPPLPGKETTLWTCPKCKGVNRSNRKFCFKCSAPSPIVEFKPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836I0G9</accession>
    <name>A0A836I0G9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Topoisomerase I C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_07459</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the type IB topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000004">
        <property type="protein sequence ID" value="KAG5487781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065978.1">
        <property type="nucleotide sequence ID" value="XM_067209346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836I0G9"/>
    <dbReference type="SMR" id="A0A836I0G9"/>
    <dbReference type="GeneID" id="92363280"/>
    <dbReference type="KEGG" id="loi:92363280"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025834">
        <property type="entry name" value="TopoI_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014727">
        <property type="entry name" value="TopoI_cat_a/b-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018521">
        <property type="entry name" value="TopoIB_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051062">
        <property type="entry name" value="Topoisomerase_IB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290">
        <property type="entry name" value="DNA TOPOISOMERASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290:SF18">
        <property type="entry name" value="DNA TOPOISOMERASE TYPE IB SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14370">
        <property type="entry name" value="Topo_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00176">
        <property type="entry name" value="TOPO_IB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52038">
        <property type="entry name" value="TOPO_IB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Topoisomerase I C-terminal" evidence="3">
        <location>
            <begin position="196"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="74"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="97"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="1">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5487781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="263" mass="28272" checksum="C80347F4481EEAD6" modified="2021-09-29" version="1">MEPTQAPPVAPPSVPTAVPKKTPVVMSALKLKMSPSVRATLAAAGVLGQRPRPTEPADEDALLRVTPMKVMAPAVNMVVTPPTTVAPPPKVRRVERSPSSSSSSSGTSSSSPDDDSSSDASSDSDSSSYSSDDRSPSSAVSEEEATLFDIARSQGLVNKEILTQEEEEAPTLAPPRPPVVRSFPSDIDKALARYRERLNREENIIRIKDDNKAVSLGTSKINYIDPRIVCSWAKAQDVPISKVFSATILKKFPWALNAENFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836K6H5</accession>
    <name>A0A836K6H5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">14-3-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_00345</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 14-3-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058530.1">
        <property type="nucleotide sequence ID" value="XM_067202429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836K6H5"/>
    <dbReference type="SMR" id="A0A836K6H5"/>
    <dbReference type="GeneID" id="92356363"/>
    <dbReference type="KEGG" id="loi:92356363"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08774">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.190.20:FF:000001">
        <property type="entry name" value="14-3-3 gamma 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
        <property type="entry name" value="14-3-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000308">
        <property type="entry name" value="14-3-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023409">
        <property type="entry name" value="14-3-3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023410">
        <property type="entry name" value="14-3-3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18860">
        <property type="entry name" value="14-3-3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00244">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000868">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00305">
        <property type="entry name" value="1433ZETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00101">
        <property type="entry name" value="14_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00796">
        <property type="entry name" value="1433_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="14-3-3" evidence="3">
        <location>
            <begin position="30"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000868-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5464899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="258" mass="29668" checksum="679FB168A8FDE524" modified="2021-09-29" version="1">MTETIKWKNVAIQDEVVPKHSEIKLPDDLAELIYMAKLAEESERFDEMLLCIRKYVRLNSELDTEERNLLSVAYKNVITPRRNAWRVITSIESRETAKDNSATLPLVVNMRRELEAELSPLCDDLLSLLDTYLIPAAQGGEAKVFYLKMKGDYHRYYAEIDSGDGQKQAALNAYQKATDVANSSLAPTHPIRLGLALNFSVFYYEIMKEHEKGFQLARQAYDEAVTELETLDDEAYHESNTIVRLLRENLNLWTDDQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836K9B2</accession>
    <name>A0A836K9B2_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_01153</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5468064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059866.1">
        <property type="nucleotide sequence ID" value="XM_067203216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836K9B2"/>
    <dbReference type="GeneID" id="92357150"/>
    <dbReference type="KEGG" id="loi:92357150"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5468064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="203" mass="21952" checksum="B36A3B9D39103CE9" modified="2021-09-29" version="1">MPFSMSELQTAFCDALAGCPPDAPQEAREMAMSLAGASIFAGSWQPMEATRLPVRAYLRVSGEFDTEDLCRAAVVRVVDAALHDLFGDDAVNAFIGAKACESADVVGACEQILRKYLLWILDGYLNYDGTDQCPFHEALKSTVCAFSTEWSQTFAPMFTEAESSNELFSLLITRGAQHRAAAAVTSPDDAKARMLTAMAIQCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KAK8</accession>
    <name>A0A836KAK8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TAX-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_01642</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059381.1">
        <property type="nucleotide sequence ID" value="XM_067203690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KAK8"/>
    <dbReference type="SMR" id="A0A836KAK8"/>
    <dbReference type="GeneID" id="92357624"/>
    <dbReference type="KEGG" id="loi:92357624"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053248">
        <property type="entry name" value="Zinc_finger_MYND_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46533">
        <property type="entry name" value="ZINC FINGER MYND DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46533:SF1">
        <property type="entry name" value="ZINC FINGER MYND DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5466491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="408" mass="44963" checksum="3B8FB41191654F21" modified="2021-09-29" version="1">MSYSSRVAPISTAATSSAKCGAKKSGSSLAAAAHDKSQYDITNVTWGTLESRFDELITLMHTPATGVNALEVSATNRQRIGSAIATLLDKAQDECRVLLLEGDAGAAEKAGVLVLHLREKFYKPNNVELIPAYLHLARTKQFLKRYGDAEDMLLLAQYIMLKHTDEVTMTMKADLHQGFGLLYAADGKQEVAAQHLGRATYYLSRLQGARNVLTTFSYFDLGNVMAAKANMESAMALYDAVKEIWYAHLVNALIDVVARLEDMQTQLKYAENTPAHELRKACYASAHAFGQENLADASKMLHGICCIQQKRFHNAHPSPVRAEFILGLFLLWTDNEPEAETHLVAARAASQRFYGPRHPVVQEIEDWCAKFGLRYEASENEAPECEAVPVTGMEAAAHDDDTGDKHPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KB93</accession>
    <name>A0A836KB93_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_02783</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060355.1">
        <property type="nucleotide sequence ID" value="XM_067204803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KB93"/>
    <dbReference type="SMR" id="A0A836KB93"/>
    <dbReference type="GeneID" id="92358737"/>
    <dbReference type="KEGG" id="loi:92358737"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006862">
        <property type="term" value="P:nucleotide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000226">
        <property type="entry name" value="Mitochondrial carrier protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044712">
        <property type="entry name" value="SLC25A32-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45683">
        <property type="entry name" value="MITOCHONDRIAL NICOTINAMIDE ADENINE DINUCLEOTIDE TRANSPORTER 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="271"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="73"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="170"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="271"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5470089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="41125" checksum="281FAAC12D17DBA2" modified="2021-09-29" version="1">MDTSLVPAPECFEMGTGRLDARNPVLACSSSSSSPATRSPLPILPMISMNKWNGDVENADQVPTSLNAIGRHAPVAIHTVCSQLASATSTCVFYPFDTLKTRYMAQDGTVTRLHNGRVYSSIHRSLALIYGEEGLRTLFRGCAVAVAGSMAAWGVYMLLYRQLCNLTESTSYLERSCISVVSSTISSCVACPIFLIKSRMQLEEASRSSNYRSFLSGVRYTMQTAGVRSLWRGLPLQLFLIFPNALSIPTYDTLKRFVLQYRWHHAEITELTFFEIGICSTLTKVWILILSHPLVMMKVRMQDERATLGECQYRSVAQSISSVLKTQGPQGMYRGFCTALVHSLPRSLLHYWIYEKTLALLCRRYSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KBC8</accession>
    <name>A0A836KBC8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ABC transporter-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_02888</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060460.1">
        <property type="nucleotide sequence ID" value="XM_067204908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KBC8"/>
    <dbReference type="GeneID" id="92358842"/>
    <dbReference type="KEGG" id="loi:92358842"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF503">
        <property type="entry name" value="MITOCHONDRIAL POTASSIUM CHANNEL ATP-BINDING SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="339"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="122"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="473"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5470194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="709" mass="75333" checksum="33DFB25A5CCD8A16" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KBK7</accession>
    <name>A0A836KBK7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">60S ribosomal protein L12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_01397</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059142.1">
        <property type="nucleotide sequence ID" value="XM_067203451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KBK7"/>
    <dbReference type="SMR" id="A0A836KBK7"/>
    <dbReference type="GeneID" id="92357385"/>
    <dbReference type="KEGG" id="loi:92357385"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1550.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="entry name" value="Ribosomal protein L11/L12, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_uL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_uL11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_uL11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_uL11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_uL11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_uL11_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="Ribosomal L11/L12e N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL11 N-terminal" evidence="6">
        <location>
            <begin position="15"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL11 C-terminal" evidence="5">
        <location>
            <begin position="74"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5466252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="164" mass="17559" checksum="A3E9014BDAB27FAD" modified="2021-09-29" version="1">MPPKFDPNQEIIVVVRAVGGEVAATASLAPKVGPLGLNAKKIGEDIAKCTKDWKGLKVTCELRVKNRVATVMVTPSVASRLIRALKEPPRDRKKVKNIKHSGNIPFAEIIKIAKEAQGKSMGSDLKAVVMEVLGTAVSIGCTVDGESPRDIQTKVQEGKLKVPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KBW1</accession>
    <name>A0A836KBW1_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_00592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058771.1">
        <property type="nucleotide sequence ID" value="XM_067202670.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92356604"/>
    <dbReference type="KEGG" id="loi:92356604"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5465140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1301" mass="145820" checksum="FBCB5414171A7DB0" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KCS7</accession>
    <name>A0A836KCS7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">LSCM4_03153</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">LSCM4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060721.1">
        <property type="nucleotide sequence ID" value="XM_067205169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KCS7"/>
    <dbReference type="GeneID" id="92359103"/>
    <dbReference type="KEGG" id="loi:92359103"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005745">
        <property type="term" value="C:m-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000003">
        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000982">
        <property type="entry name" value="Inactive ATP-dependent zinc metalloprotease FTSHI 2 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050928">
        <property type="entry name" value="ATP-dep_Zn_Metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655:SF2">
        <property type="entry name" value="AFG3 LIKE MATRIX AAA PEPTIDASE SUBUNIT 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="346"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="18">
        <location>
            <begin position="438"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="175"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="637"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="639"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="655"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAG5471604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="950" mass="103316" checksum="57F7136D92D1BA62" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KD09</accession>
    <name>A0A836KD09_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA polymerase-associated protein LEO1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059215.1">
        <property type="nucleotide sequence ID" value="XM_067203524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KD09"/>
    <dbReference type="GeneID" id="92357458"/>
    <dbReference type="KEGG" id="loi:92357458"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990269">
        <property type="term" value="F:RNA polymerase II C-terminal domain phosphoserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007149">
        <property type="entry name" value="Leo1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23146">
        <property type="entry name" value="LEO1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23146:SF0">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN LEO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04004">
        <property type="entry name" value="Leo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5466325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="568" mass="63347" checksum="00DBEB02D3D57519" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KDN8</accession>
    <name>A0A836KDN8_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_02722</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060297.1">
        <property type="nucleotide sequence ID" value="XM_067204745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KDN8"/>
    <dbReference type="GeneID" id="92358679"/>
    <dbReference type="KEGG" id="loi:92358679"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035859">
        <property type="term" value="C:Seh1-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF3">
        <property type="entry name" value="NUCLEOPORIN SEH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="5"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5470031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="370" mass="40388" checksum="7DC14D7ACD26AEC6" modified="2021-09-29" version="1">MASLFTQHKTYVHHVALDPSGTLLASCSSDKTVEVFHRRSVAGGGAVWEPGCAMHDHAGPVLRMAWCQHREHGPLLATAGADRWIYIYRIIISSHEGRTLLHTVRWSPVRGYEKDVITDVAFVPPQQYHSLLLSTASLDGCVRLYEVHQPQQFPCVCRISPEADTAAEGASDSTASAAGVSVSAASHSNASAVAERRDDGVVPPSASSVSLLRSGGVTAIGWFPGSAERTMTLAIGTVSGRFFLYRYIKDSSSFMAISVPQVESGELRCSSPVCNVSWAPCVGRRFQLLSICCRCEVFILRLNCVSPSIDEKRSFELFRVRFGAVSASWSRSSTLLYLATDDRQTQVVVLQMANPLDHQSWKVVSRNAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KDS6</accession>
    <name>A0A836KDS6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LSCM4_02845</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="4"/>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060417.1">
        <property type="nucleotide sequence ID" value="XM_067204865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KDS6"/>
    <dbReference type="SMR" id="A0A836KDS6"/>
    <dbReference type="GeneID" id="92358799"/>
    <dbReference type="KEGG" id="loi:92358799"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000016">
        <property type="entry name" value="Protein phosphatase 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF803">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="12">
        <location>
            <begin position="135"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="396"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="399"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="448"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="469"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="482"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG5470151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="560" mass="60398" checksum="2F568E4984671CFB" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KDX7</accession>
    <name>A0A836KDX7_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_02330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="protein sequence ID" value="KAG5468937.1"/>
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            <end position="56"/>
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            <end position="348"/>
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            <end position="391"/>
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    </feature>
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            <end position="592"/>
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    </feature>
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    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5468937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Leishmania orientalis</name>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">LSCM4</strain>
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    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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            <end position="124"/>
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        <source>
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        </source>
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</entry>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
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    </dbReference>
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        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
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    <evidence type="ECO:0000256" key="2">
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KGK2</accession>
    <name>A0A836KGK2_9TRYP</name>
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        </submittedName>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
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    </dbReference>
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    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
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            <end position="248"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="338"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5464768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="469" mass="50761" checksum="3ED74574E0AB58B3" modified="2021-09-29" version="1">MYPALPRWSDGGGSAAPSVQRVALAAAPPYAQNRGATANDGYAITPTLAHAAPPSVQATKTSRSGRLFVNHNAPLPLQPGASSTVYSTNTPIPGAGALPGCSIHSHVGDLSQPIRSADRADDHIGVIAAAFAEGHLAAALPHPSGLSRPAHGFDRRGLARGSTVQALVDALRGSRSPLLLGIEGVQTGEEVILDMRPARVRSSTSSTPNGSHDAMQLRRQLEKATADLKAMMSANRRQRQEHQQQRAEWLVILNECEARLCNVQSSQSSREQLMCDELIYIIKQLLSEIKAQAAKEHAVEQAHANSKADWDTGRSALLRELEAARAALGTQLSTNNLAHAHKEEADRLRSELEALQRSAADQQRSLEEKLIQTQSALQSTESELKQCRQERDQHNYLVAQCRLFIQHVCQPGFSVVNGPSLEPVEKNRPEPTGFVLVPLAVLLHGYALLPEGDRQALINHYDARAKSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836KGM3_9TRYP</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058474.1">
        <property type="nucleotide sequence ID" value="XM_067202373.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92356307"/>
    <dbReference type="KEGG" id="loi:92356307"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1401"/>
            <end position="1441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5464843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1441" mass="167210" checksum="58BEE9C5B699BEB9" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KGS6</accession>
    <name>A0A836KGS6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cytidyltransferase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_02889</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060461.1">
        <property type="nucleotide sequence ID" value="XM_067204909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KGS6"/>
    <dbReference type="SMR" id="A0A836KGS6"/>
    <dbReference type="GeneID" id="92358843"/>
    <dbReference type="KEGG" id="loi:92358843"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695:SF46">
        <property type="entry name" value="BIFUNCTIONAL COENZYME A SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695">
        <property type="entry name" value="DEPHOSPHO-COA KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="2">
        <location>
            <begin position="189"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5470195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="333" mass="36085" checksum="39375E5D259554B5" modified="2021-09-29" version="1">MTPSVLLSTAHGKEVNAKSLVSYLIRSALTPIASHGATPAGSASTAPGLVSYCCPRSELRCGNGGGVDVYLAIHNQHRSTFLEHSVYLYSVALDVCPQLSISIIPVIGIPDESARETVSAEDIQVSETSSSSSAPSKHRQQLSEMPRRGSDIIKLHDDVSAELRDQKLVDKSFMRDAEGFQPHYKYVAVGGTFDHFHSGHKVLLSTAALHAMHKLRVGVTDVSLLARKKFAESLQPMNVRMENVTRFLRKVRPDLELDLTPISEVSGGTKDIPEIEALVVSPETGNSLRVINEMRAANGGLAPMVGIWIPEVRSPSGKSISSTALRELQTRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KI29</accession>
    <name>A0A836KI29_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cullin family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_01569</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059308.1">
        <property type="nucleotide sequence ID" value="XM_067203617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KI29"/>
    <dbReference type="SMR" id="A0A836KI29"/>
    <dbReference type="GeneID" id="92357551"/>
    <dbReference type="KEGG" id="loi:92357551"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044554">
        <property type="entry name" value="ANAPC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057975">
        <property type="entry name" value="TPR_ANAPC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45957">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45957:SF1">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25773">
        <property type="entry name" value="TPR_ANAPC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cullin family profile" evidence="3">
        <location>
            <begin position="486"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="171"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="195"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5466418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="870" mass="95151" checksum="CDE15D1559831FD9" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KJ79</accession>
    <name>A0A836KJ79_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LSCM4_04056</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061983.1">
        <property type="nucleotide sequence ID" value="XM_067206046.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836KJ79"/>
    <dbReference type="GeneID" id="92359980"/>
    <dbReference type="KEGG" id="loi:92359980"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1220:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000013">
        <property type="entry name" value="Dynein Heavy Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002141">
        <property type="entry name" value="Dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1120:FF:000007">
        <property type="entry name" value="Dynein heavy chain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000063">
        <property type="entry name" value="dynein heavy chain 6, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.130:FF:000015">
        <property type="entry name" value="Dynein heavy chain 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.30:FF:000010">
        <property type="entry name" value="Dynein heavy chain family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000017">
        <property type="entry name" value="Dynein heavy chain, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.20:FF:000019">
        <property type="entry name" value="Dynein heavy chain, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002429">
        <property type="entry name" value="Dynein heavy chain, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000362">
        <property type="entry name" value="Dynein, axonemal, heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.280:FF:000020">
        <property type="entry name" value="Putative dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000014">
        <property type="entry name" value="Putative dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001145">
        <property type="entry name" value="Putative dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054354">
        <property type="entry name" value="DYNC2H1-like_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703">
        <property type="entry name" value="DYNEIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703:SF36">
        <property type="entry name" value="DYNEIN HEAVY CHAIN, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22597">
        <property type="entry name" value="DYN_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="8 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="1491"/>
            <end position="1630"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="1773"/>
            <end position="1916"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="2133"/>
            <end position="2282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="372"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="1205"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="2975"/>
            <end position="3016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG5474877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="4230" mass="474124" checksum="68E8D62D808CA766" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KJD4</accession>
    <name>A0A836KJD4_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_00913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059630.1">
        <property type="nucleotide sequence ID" value="XM_067202980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KJD4"/>
    <dbReference type="GeneID" id="92356914"/>
    <dbReference type="KEGG" id="loi:92356914"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5467828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="741" mass="80994" checksum="75C034B705760AED" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KKE9</accession>
    <name>A0A836KKE9_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </comment>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <location>
            <begin position="648"/>
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        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5478041.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KME7</accession>
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        <recommendedName>
            <fullName evidence="5">RNA binding protein</fullName>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="308" mass="34494" checksum="FD67CCF6B899CB6D" modified="2021-09-29" version="1">MKSKIEADAAAMGACHGDAMMGPAMSTTEPMQSVYNRTQKRVPVFQESLMMYEQQMMQVMEDLRTLAMDVNALRAHYEEALQEKLYIENLAAQAEKRVQDVKDIVDRYVGVKDAVVASDGFTYERETISSYIDGCKEAGGTPTSYQTEKPLTSLLIPNRSLKTLVDRLVTLQKAEPTPPTPADRTPVQQHPKLTTTGRPGNVPGNQHDSQRRNMHVAGKDSSSPVELNAKRERVHPCIRVYGYCNYNESCAYAKYPYDACLSNLKNKCRFKNQCHERHVEFRGPLDDYGNPLSANQVPHQENSASGSV</sequence>
</entry>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
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                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
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                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063448.1">
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    </dbReference>
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    </evidence>
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        </source>
    </evidence>
    <sequence length="649" mass="73613" checksum="C26A60336374F688" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KNM8</accession>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
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                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
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    </reference>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5477185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="101" mass="10927" checksum="F5AF0814C3D01A07" modified="2021-09-29" version="1">MRRSSVRCGSIFHSPGAADHWFSGTASTGTWRGAFTSFALCLCGIAVINQFCRGNPMGRCKYENEIVMPLQRTRVPPPDTYGFVDAESDAGGHKQPPAPHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KNW5</accession>
    <name>A0A836KNW5_9TRYP</name>
    <protein>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="protein sequence ID" value="KAG5472718.1"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="164"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5472718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="180" mass="19920" checksum="502933F923D7F1A7" modified="2021-09-29" version="1">MGLLSLRELVVLFDTQLQQLTLSYLAAGFFAVHTAVVSVASLVVCGSLALATSSDAASIFAPAPLLFTSFASFASISVLTFMTLTLFYRLIGGRFVYSPRATGCVVDWILDTVCRPVVEDMAHLLLAPNRRRERGVFLLSLWLFGEVGRFLSFWSVCTLASMLWCGWSVRRAWRQHQCAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836KPY6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SNF2 N-terminal domain family protein</fullName>
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        <name evidence="5" type="ORF">LSCM4_04723</name>
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    <organism evidence="5 6">
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    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000023">
        <property type="protein sequence ID" value="KAG5478490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063151.1">
        <property type="nucleotide sequence ID" value="XM_067206704.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92360638"/>
    <dbReference type="KEGG" id="loi:92360638"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="908"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="1118"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
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        <location>
            <begin position="216"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="632"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1171"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1361"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1454"/>
            <end position="1479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="216"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="635"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1393"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1468"/>
            <end position="1479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5478490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1616" mass="172420" checksum="749ECEA3B6055A14" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KS34</accession>
    <name>A0A836KS34_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Sec20 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LSCM4_05964</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SEC20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000011">
        <property type="protein sequence ID" value="KAG5485329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065066.1">
        <property type="nucleotide sequence ID" value="XM_067207892.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="92361826"/>
    <dbReference type="KEGG" id="loi:92361826"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005606">
        <property type="entry name" value="Sec20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056173">
        <property type="entry name" value="Sec20_C"/>
    </dbReference>
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        <property type="entry name" value="BNIP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12825:SF0">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN SEC20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03908">
        <property type="entry name" value="Sec20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Sec20 C-terminal" evidence="12">
        <location>
            <begin position="172"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="85"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG5485329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="271" mass="29453" checksum="D640E88D78692560" modified="2021-09-29" version="1">MEVTAPLHRAAAMLPSLESVPPLPPKAAEVLVALTRHADRALRELTTAHRAFVSNRTQRLHGALSIAVAHAQQVLRALEAVREQRERERHQLQQPLRPSAFPATQPASPPAESQTQRTEEHQLCVQLEKTRIDLRRELPRAVAEVEGADNISEGGGTSASGRSAASAAAALRSLLHTRSLLSVELEKMDSVVQGLAGSSESLAALQQSLQNVHTSMETAQRMVRTLLTVQSRDDLLLRVSAALFALVVLYVVAQRVFRLFPATVYVAVGDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KSW9</accession>
    <name>A0A836KSW9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA2/NAM7 helicase helicase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_06817</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000009">
        <property type="protein sequence ID" value="KAG5486109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065440.1">
        <property type="nucleotide sequence ID" value="XM_067208729.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836KSW9"/>
    <dbReference type="GeneID" id="92362663"/>
    <dbReference type="KEGG" id="loi:92362663"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF495">
        <property type="entry name" value="HELICASE SENATAXIN ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="3">
        <location>
            <begin position="1892"/>
            <end position="1992"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="3">
        <location>
            <begin position="2046"/>
            <end position="2123"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="4">
        <location>
            <begin position="2131"/>
            <end position="2371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="570"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1234"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1295"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1361"/>
            <end position="1394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2315"/>
            <end position="2335"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1181"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1255"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1297"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1362"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1377"/>
            <end position="1394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5486109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2493" mass="267193" checksum="5702E6BA6D102E4A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KT78</accession>
    <name>A0A836KT78_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_04587</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062779.1">
        <property type="nucleotide sequence ID" value="XM_067206570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KT78"/>
    <dbReference type="GeneID" id="92360504"/>
    <dbReference type="KEGG" id="loi:92360504"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5477368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="123" mass="13844" checksum="C1F2C5A01FAE67A9" modified="2021-09-29" version="1">MEQERRLAEREVREVVADAESPLAQRHVRESLKKNKFALVLYAMALFTPALFLVSFYTAKAREIRANFRDPYALPEGFDPKTGEFASGSAPSKSAHELPIVQLLFMGEEPGKYGQRASKRSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KT79</accession>
    <name>A0A836KT79_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CTLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_07337</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000008">
        <property type="protein sequence ID" value="KAG5486409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065475.1">
        <property type="nucleotide sequence ID" value="XM_067209232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KT79"/>
    <dbReference type="GeneID" id="92363166"/>
    <dbReference type="KEGG" id="loi:92363166"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5486409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="229" mass="25096" checksum="4AAF6DFA295639E4" modified="2021-09-29" version="1">MDLTDKSMWTLVEEAVIEDRGEDEEEVLAQMVRSYLARRGLADTLAAFDEEHLSYGGSLKFPYNGDRDAPKSSTSTGVLDSKSTAVGASVNGGAPVNEASAGMEKRKAAQLLCLQKKYEAAAALMEPSSLARIRLLCIQAQSLEDRAAAVFYLATHVAPLVPFCNDPTMGHRVYTAALSEVLSPCRERSIPDTEALAREVNDELCGREQRSSLHVLFNWAYWQETAYTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KTS7</accession>
    <name>A0A836KTS7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">V-ATPase proteolipid subunit C-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LSCM4_05348</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the ATPase C chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5477953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062860.1">
        <property type="nucleotide sequence ID" value="XM_067207292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KTS7"/>
    <dbReference type="SMR" id="A0A836KTS7"/>
    <dbReference type="GeneID" id="92361226"/>
    <dbReference type="KEGG" id="loi:92361226"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033177">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, proton-transporting domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18182">
        <property type="entry name" value="ATP-synt_Fo_c_ATP5G3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.20.10:FF:000008">
        <property type="entry name" value="ATPase subunit 9 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.10">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01396">
        <property type="entry name" value="ATP_synth_c_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020537">
        <property type="entry name" value="ATP_synth_F0_csu_DDCD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038662">
        <property type="entry name" value="ATP_synth_F0_csu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031">
        <property type="entry name" value="ATP SYNTHASE LIPID-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031:SF0">
        <property type="entry name" value="ATPASE PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00124">
        <property type="entry name" value="ATPASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00605">
        <property type="entry name" value="ATPASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0138">CF(0)</keyword>
    <keyword evidence="7 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="13">
        <location>
            <begin position="42"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG5477953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="106" mass="10986" checksum="528E30DD950EF76F" modified="2021-09-29" version="1">MMRRVIAQPIARRAAAASSALAVAPRQASTVAISVQGLHYVGTGLAAIALAGVGMGIGTIFGCLLISCARQPNLTKMLFNYAILGFALTEAIGLFALMLAFLMLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KUG6</accession>
    <name>A0A836KUG6_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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    <dbReference type="KEGG" id="loi:92362681"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5486127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="139" mass="16071" checksum="4AEED83D832BDC23" modified="2021-09-29" version="1">MPVDYSKKLDALRELYERVQQKDASIPEEAYAAAGVKNKARLKDIEKEISATKRKVSHEVKKVTNEEIEKEYEAIAKEHNMTVEEFKETVMGKGRQAGVGSEFSERHAAQRKERAEQRDLKETRRQVERGDFDLAVDYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KVI8</accession>
    <name>A0A836KVI8_9TRYP</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_07787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000006">
        <property type="protein sequence ID" value="KAG5487297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065794.1">
        <property type="nucleotide sequence ID" value="XM_067209664.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836KVI8"/>
    <dbReference type="GeneID" id="92363598"/>
    <dbReference type="KEGG" id="loi:92363598"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="631"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="902"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1501"/>
            <end position="1526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="407"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="661"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="682"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5487297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1600" mass="166550" checksum="56709A70EC801743" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KWA4</accession>
    <name>A0A836KWA4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Calpain catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_06195</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000020">
        <property type="protein sequence ID" value="KAG5480428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063759.1">
        <property type="nucleotide sequence ID" value="XM_067208119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KWA4"/>
    <dbReference type="SMR" id="A0A836KWA4"/>
    <dbReference type="GeneID" id="92362053"/>
    <dbReference type="KEGG" id="loi:92362053"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015232">
        <property type="entry name" value="DUF1935"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036310">
        <property type="entry name" value="Smp-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF423">
        <property type="entry name" value="LEUCINE-RICH REPEAT PROTEIN (LRRP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09149">
        <property type="entry name" value="DUF1935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101601">
        <property type="entry name" value="Smp-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="4">
        <location>
            <begin position="293"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="525"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5480428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="792" mass="88411" checksum="CD73AA760ACD9616" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KYI7</accession>
    <name>A0A836KYI7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutaminyl cyclase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_08100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000005">
        <property type="protein sequence ID" value="KAG5487655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065943.1">
        <property type="nucleotide sequence ID" value="XM_067209976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KYI7"/>
    <dbReference type="GeneID" id="92363910"/>
    <dbReference type="KEGG" id="loi:92363910"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016603">
        <property type="term" value="F:glutaminyl-peptide cyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040234">
        <property type="entry name" value="QC/QCL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12283">
        <property type="entry name" value="GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12283:SF6">
        <property type="entry name" value="GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5487655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="908" mass="102284" checksum="681E94AF2BDD0898" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836L1B8</accession>
    <name>A0A836L1B8_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000011">
        <property type="protein sequence ID" value="KAG5485318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065055.1">
        <property type="nucleotide sequence ID" value="XM_067207881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836L1B8"/>
    <dbReference type="GeneID" id="92361815"/>
    <dbReference type="KEGG" id="loi:92361815"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5485318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="179" mass="19141" checksum="28C82B425774A5F3" modified="2021-09-29" version="1">MASAADSSAAPLLPPMPSALRQLTIAVERLNAASSLPADASVTSPKGRSTTKPPEQLTSAPPADDDVVPTAELLLQVDALQEQYRRLLELAQEPYRSRKSDPAESSSGGGSRGLEARAESLMAQLEVAVGQLQQGIRSKQAQATRLVLLNALRREAAERRQLVVKMEGVLSASRQHVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836L254</accession>
    <name>A0A836L254_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitochondrial import inner membrane translocase subunit TIM22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_06806</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the TIM22 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion inner membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000009">
        <property type="protein sequence ID" value="KAG5486098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065429.1">
        <property type="nucleotide sequence ID" value="XM_067208718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836L254"/>
    <dbReference type="SMR" id="A0A836L254"/>
    <dbReference type="GeneID" id="92362652"/>
    <dbReference type="KEGG" id="loi:92362652"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042721">
        <property type="term" value="C:TIM22 mitochondrial import inner membrane insertion complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039175">
        <property type="entry name" value="TIM22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14110">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14110:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="26"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5486098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="152" mass="16374" checksum="2485AC03D4DE8A53" modified="2021-09-29" version="1">MTSILDPRQPIEPLQRAMMVAKDSTLATAMLNVFGGYVMGFGFSLFGSMISAETSTQAMGTADFFRYSLRSAHRLAGSFAFFGFLFGGIEVALEKRRGRKDQWNPTIAGAIIGGGYGWRSYKHPGLAAGIVGGAAFSLVFEKMLDAMGMAQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FYK3</accession>
    <name>A0A836FYK3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">inosine/xanthosine triphosphatase</fullName>
            <ecNumber evidence="9">3.6.1.73</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LSCM4_03254</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">LSCM4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ITP + H2O = IDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28330"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58280"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.73"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>XTP + H2O = XDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28406"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59884"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.73"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.73" evidence="9"/>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060819.1">
        <property type="nucleotide sequence ID" value="XM_067205267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836FYK3"/>
    <dbReference type="SMR" id="A0A836FYK3"/>
    <dbReference type="GeneID" id="92359201"/>
    <dbReference type="KEGG" id="loi:92359201"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103023">
        <property type="term" value="F:ITPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006772">
        <property type="term" value="P:thiamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.950.10:FF:000002">
        <property type="entry name" value="Inosine/xanthosine triphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00648">
        <property type="entry name" value="Non_canon_purine_NTPase_YjjX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002786">
        <property type="entry name" value="Non_canon_purine_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026533">
        <property type="entry name" value="NTPase/PRRC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050299">
        <property type="entry name" value="YjjX_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34699">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34699:SF2">
        <property type="entry name" value="NON-CANONICAL PURINE NTP PHOSPHATASE_PRRC1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01931">
        <property type="entry name" value="NTPase_I-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-canonical purine NTP phosphatase/PRRC1" evidence="12">
        <location>
            <begin position="7"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG5471702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="179" mass="19318" checksum="64B55B3ED65E45D0" modified="2021-09-29" version="1">MTVWAVGTTNRAKAESVVAVVHRCFPRETHDVRLCKVDSGVSDQPMSAEETQRGALNRAKAALEAVSDADYGVGLEGGIEYIAGRWFECGWMVILERTTGKCGIGSSARFEMSETMMRPILNEGKELADVIDHLTGEEDVRSGLGAMGVLTAGCLGRAAAYEHGLVFALAPFLSDSKYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G032</accession>
    <name>A0A836G032_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_00604</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <text>ATP + H2O = ADP + phosphate + H(+)</text>
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        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="protein sequence ID" value="KAG5466319.1"/>
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        <property type="entry name" value="AB_hydrolase_fold"/>
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        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G6D6</accession>
    <name>A0A836G6D6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cation-transporting P-type ATPase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LSCM4_01384</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059129.1">
        <property type="nucleotide sequence ID" value="XM_067203438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G6D6"/>
    <dbReference type="SMR" id="A0A836G6D6"/>
    <dbReference type="GeneID" id="92357372"/>
    <dbReference type="KEGG" id="loi:92357372"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098662">
        <property type="term" value="P:inorganic cation transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000123">
        <property type="entry name" value="Calcium motive P-type ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000016">
        <property type="entry name" value="Calcium-transporting P-type ATPase putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="456"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="985"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1026"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1065"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1100"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="12">
        <location>
            <begin position="183"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG5466239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1210" mass="132271" checksum="7DA5EC1812263E58" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G6K1</accession>
    <name>A0A836G6K1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Prenyltransferase alpha-alpha toroid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_05132</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062405.1">
        <property type="nucleotide sequence ID" value="XM_067207102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G6K1"/>
    <dbReference type="SMR" id="A0A836G6K1"/>
    <dbReference type="GeneID" id="92361036"/>
    <dbReference type="KEGG" id="loi:92361036"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005965">
        <property type="term" value="C:protein farnesyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004660">
        <property type="term" value="F:protein farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF6">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="9">
        <location>
            <begin position="89"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="58"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5476172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="722" mass="78445" checksum="4127F1BCDB2C2DD5" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G751</accession>
    <name>A0A836G751_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_00762</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLPTM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059486.1">
        <property type="nucleotide sequence ID" value="XM_067202836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G751"/>
    <dbReference type="GeneID" id="92356770"/>
    <dbReference type="KEGG" id="loi:92356770"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008429">
        <property type="entry name" value="CLPTM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347">
        <property type="entry name" value="CLEFT LIP AND PALATE ASSOCIATED TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347:SF0">
        <property type="entry name" value="LIPID SCRAMBLASE CLPTM1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05602">
        <property type="entry name" value="CLPTM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="465"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5467684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="583" mass="66342" checksum="5189FC83A31C8089" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GAK9</accession>
    <name>A0A836GAK9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pteridine reductase</fullName>
            <ecNumber evidence="3">1.5.1.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_04639</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.33" evidence="3"/>
    <dbReference type="EMBL" id="JAFHLR010000023">
        <property type="protein sequence ID" value="KAG5478407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063068.1">
        <property type="nucleotide sequence ID" value="XM_067206621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GAK9"/>
    <dbReference type="SMR" id="A0A836GAK9"/>
    <dbReference type="GeneID" id="92360555"/>
    <dbReference type="KEGG" id="loi:92360555"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047040">
        <property type="term" value="F:pteridine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd05357">
        <property type="entry name" value="PR_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014058">
        <property type="entry name" value="Pteridine_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02685">
        <property type="entry name" value="pter_reduc_Leis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G02870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639:SF1">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="NCBIfam" id="TIGR02685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR614058-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR614058-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5478407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="288" mass="30731" checksum="9D04B993A7A0A72E" modified="2021-09-29" version="1">MLAPTAPVALVTGAAKRIGRTIAEALHAEGYAVCLHYHLSASDANGLASELNTRRPNSAITVQADLSAVAATSLNGADGSAPVSLVKRCVDLVYACYNHWGRCDVLVNNASAYYPTPLLRKDEEGRETSDGEREVIETAAADVFGSNAIAPYFLIKAFAQRLADTPTEQRGGNYSIVNMVDAMTNQPLLGFTMYTMAKGALEGLTRSAALELAPLRVRVNGVGPGLSVLAEDMAPDMREDYRRKVPLYQRECTAAEVSDAVLFLCSSKAKYITGTCVNVDGGYSLTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GBI9</accession>
    <name>A0A836GBI9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Roadblock/LAMTOR2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_03432</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GAMAD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060988.1">
        <property type="nucleotide sequence ID" value="XM_067205436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GBI9"/>
    <dbReference type="SMR" id="A0A836GBI9"/>
    <dbReference type="GeneID" id="92359370"/>
    <dbReference type="KEGG" id="loi:92359370"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10779">
        <property type="entry name" value="DYNEIN LIGHT CHAIN ROADBLOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103196">
        <property type="entry name" value="Roadblock/LC7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Roadblock/LAMTOR2" evidence="2">
        <location>
            <begin position="18"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5471871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="119" mass="12979" checksum="36D91AAED77D7BA7" modified="2021-09-29" version="1">MSKANPVAAERAAHLQNVEDILSRIAHHKGVLGYFIMEPLKGKLLSFAGFRGSSKEAHRYADTLGGFIDLTTSTVRTIDWNDQLTFLRISCGTVDILVAPDANKEYTMVVVQAVAGRCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GCL2</accession>
    <name>A0A836GCL2_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_00097</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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                <person name="Bates M.D."/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5464565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="553" mass="61481" checksum="A7A29BBEF4A1DBB9" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GGE9</accession>
    <name>A0A836GGE9_9TRYP</name>
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        <recommendedName>
            <fullName evidence="7">Guanylate cyclase domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="8" type="ORF">LSCM4_03744</name>
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        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
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    </organism>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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            <dbReference type="PROSITE" id="PS50125"/>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5468002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <source>
            <dbReference type="EMBL" id="KAG5468002.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GIK6</accession>
    <name>A0A836GIK6_9TRYP</name>
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        <recommendedName>
            <fullName evidence="4">RIIa domain-containing protein</fullName>
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        <name evidence="2" type="ORF">LSCM4_01218</name>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067203279.1"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A836GIK6"/>
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    <dbReference type="KEGG" id="loi:92357213"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47391">
        <property type="entry name" value="Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5466080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="311" mass="31739" checksum="8D81E41477C84E09" modified="2021-09-29" version="1">MPFGPSVRSNLECTTAPTATEVGVNGAGAVSGVTTAAASSPSAVPAGGVVRSCGTTHNLPRATLQRMGSSRGCLDGATTAPRGYNTSAPATPTAADSAKGAPHISPAPQPSSPSCVHAPGARHASEGKTSAGTLPALTLATPPCASSAPNDIGASVSITTSSPSSTVALPRVCPRRTSNISMELTEDEGGYSNKPTSRWASLGRPNGTSSPTVTRRAVAQLPSLSTTDSGQRPPVGADVATVAGTSSSHRVEASSSCSVSPSHREHESYFRENNIPSLFNELSEALLDAQPEDPVLFMKEWLQRRRDTIAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GIP8</accession>
    <name>A0A836GIP8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Stress-inducible protein STI1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_00006</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058199.1">
        <property type="nucleotide sequence ID" value="XM_067202098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GIP8"/>
    <dbReference type="SMR" id="A0A836GIP8"/>
    <dbReference type="GeneID" id="92356032"/>
    <dbReference type="KEGG" id="loi:92356032"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000221">
        <property type="entry name" value="Mitochondrial import receptor subunit TOM34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000020">
        <property type="entry name" value="Stress-induced phosphoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904:SF523">
        <property type="entry name" value="STRESS-INDUCED-PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904">
        <property type="entry name" value="TPR REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="72"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="134"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="206"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5464568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="255" mass="28723" checksum="5D4E1923128EBE54" modified="2021-09-29" version="1">MEDFKTKGNDAFRLKKYEEAIEWYTKAIALDPDSEASGALYSNRAGSWQNLNNFARAAADSEQCIRVRPDWLKGYFRKGVALESMGKYDEAQRAFQDALKLSPGNEEVMDKLQSINNKVRERNEKAKSKECKTPEEAKVLGNSLFKDGKYDQAAEFYTRAIELQKEPVKEKAVYYANRAACHQQTHMYALMADDCNAALTIDPANVKAYLRRGIAHEGMEKWKLALADYTKAQSLSPGVAGASQGILRCQRALRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GJ55</accession>
    <name>A0A836GJ55_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AN1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_03864</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061795.1">
        <property type="nucleotide sequence ID" value="XM_067205858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GJ55"/>
    <dbReference type="SMR" id="A0A836GJ55"/>
    <dbReference type="GeneID" id="92359792"/>
    <dbReference type="KEGG" id="loi:92359792"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="AN1-type" evidence="5">
        <location>
            <begin position="5"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="55"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5474689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="99" mass="11082" checksum="EFBFCD8891C2EC4F" modified="2021-09-29" version="1">MSEPCVFKGCSNMALVALPKCEHCNQRYCTSHLLPERHGCGDACKNAAQRQATADAAAQRQARRHLGNEDAKRRLDKKLEANEAARRKKTKLTKTKKMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GJH1</accession>
    <name>A0A836GJH1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase M14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_00436</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058619.1">
        <property type="nucleotide sequence ID" value="XM_067202518.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92356452"/>
    <dbReference type="KEGG" id="loi:92356452"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050821">
        <property type="entry name" value="Cytosolic_carboxypeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040626">
        <property type="entry name" value="Pepdidase_M14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12756">
        <property type="entry name" value="CYTOSOLIC CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12756:SF12">
        <property type="entry name" value="CYTOSOLIC CARBOXYPEPTIDASE-LIKE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18027">
        <property type="entry name" value="Pepdidase_M14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M14" evidence="5">
        <location>
            <begin position="998"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="129"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="176"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="357"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="412"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="468"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="514"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="633"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1078"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1345"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="376"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="391"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="524"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="639"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1088"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1358"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="1310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5464988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1528" mass="163354" checksum="FDF7453E3E68C92C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GKR7</accession>
    <name>A0A836GKR7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar protein 14 C-terminal Fig4-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_04977</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VAC14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000014">
        <property type="protein sequence ID" value="KAG5483822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064761.1">
        <property type="nucleotide sequence ID" value="XM_067206952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GKR7"/>
    <dbReference type="GeneID" id="92360886"/>
    <dbReference type="KEGG" id="loi:92360886"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070772">
        <property type="term" value="C:PAS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026825">
        <property type="entry name" value="Vac14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021841">
        <property type="entry name" value="VAC14_Fig4p-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16023:SF0">
        <property type="entry name" value="PROTEIN VAC14 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16023">
        <property type="entry name" value="TAX1 BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12755">
        <property type="entry name" value="Vac14_Fab1_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11916">
        <property type="entry name" value="Vac14_Fig4_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Vacuolar protein 14 C-terminal Fig4-binding" evidence="5">
        <location>
            <begin position="456"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5483822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="685" mass="74941" checksum="59A94EC256E2F4A4" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GND4</accession>
    <name>A0A836GND4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sucrose-6-phosphate hydrolase</fullName>
            <ecNumber evidence="4">3.2.1.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_04318</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Hydrolysis of terminal non-reducing beta-D-fructofuranoside residues in beta-D-fructofuranosides.</text>
            <dbReference type="EC" id="3.2.1.26"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.26" evidence="4"/>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062242.1">
        <property type="nucleotide sequence ID" value="XM_067206305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GND4"/>
    <dbReference type="SMR" id="A0A836GND4"/>
    <dbReference type="GeneID" id="92360239"/>
    <dbReference type="KEGG" id="loi:92360239"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004564">
        <property type="term" value="F:beta-fructofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08996">
        <property type="entry name" value="GH32_FFase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051214">
        <property type="entry name" value="GH32_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006232">
        <property type="entry name" value="Suc6P_hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01322">
        <property type="entry name" value="scrB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43101">
        <property type="entry name" value="BETA-FRUCTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43101:SF1">
        <property type="entry name" value="BETA-FRUCTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 32 N-terminal" evidence="5">
        <location>
            <begin position="30"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 C-terminal" evidence="6">
        <location>
            <begin position="338"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5475734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="489" mass="57264" checksum="BAE6B2EFBA414660" modified="2021-09-29" version="1">MSHEQRIEEANNAVLTIRKKIEKDFYPRYHIAPYASCMNAPCGMIYFKGLYHVFYQHHPYAVEWGPMHWGHSTSENMVHWRHHPIALAPGDDWDRDGCFAGSSVVHDDRLYVFYTGHHWLTDIADDSQIYQVQCLAISENGFSFEKRGIVVKPPAGFSHFRDPYVWFQDRRWWMVCGARDSKDQGQLLLYSTDDLEDWDDSTFTILSKSEDRNVYMWEYPSFFSLQHNQLLMFSLQGMLPEDYMFRNRYQTGLLMGVWKPNEIYSVASRFKKLDLGHDFYGAQSFLTCDGRRVFIGWLDMWDTNMPTKRHHWAGMLSLPRVLLVDPASGRIRTPPIKELESIRVNHQYLPRQTMPDNSQVRLLSDCTSYEVRVLFDLEKSTAEKYGLWLGRGLEIFVDEQTKRLVVNRHYPQYDISGYRTYALPEQALLLVHAYFDMSSVEVFVNEGEAVLSTRIYPARHDRVLSLFAVNGTAHIMRADIWALNQAVMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GNT0</accession>
    <name>A0A836GNT0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3'-phosphate/5'-hydroxy nucleic acid ligase</fullName>
            <ecNumber evidence="1">6.5.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_02368</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP = a ribonucleotidyl-ribonucleotide-RNA + GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:68076"/>
            <dbReference type="Rhea" id="RHEA-COMP:10463"/>
            <dbReference type="Rhea" id="RHEA-COMP:13936"/>
            <dbReference type="Rhea" id="RHEA-COMP:17355"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:83062"/>
            <dbReference type="ChEBI" id="CHEBI:138284"/>
            <dbReference type="ChEBI" id="CHEBI:173118"/>
            <dbReference type="EC" id="6.5.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="10">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.8" evidence="1"/>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5468975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059952.1">
        <property type="nucleotide sequence ID" value="XM_067204400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GNT0"/>
    <dbReference type="SMR" id="A0A836GNT0"/>
    <dbReference type="GeneID" id="92358334"/>
    <dbReference type="KEGG" id="loi:92358334"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003909">
        <property type="term" value="F:DNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0170057">
        <property type="term" value="F:RNA ligase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042245">
        <property type="term" value="P:RNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1860.10">
        <property type="entry name" value="tRNA-splicing ligase RtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001233">
        <property type="entry name" value="RtcB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052915">
        <property type="entry name" value="RtcB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036025">
        <property type="entry name" value="RtcB-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43749">
        <property type="entry name" value="RNA-SPLICING LIGASE RTCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43749:SF2">
        <property type="entry name" value="RNA-SPLICING LIGASE RTCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01139">
        <property type="entry name" value="RtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103365">
        <property type="entry name" value="Hypothetical protein PH1602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 10" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="GMP-histidine intermediate" evidence="8">
        <location>
            <position position="416"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="227"/>
            <end position="231"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="340"/>
            <end position="341"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="392"/>
            <end position="395"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="399"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="416"/>
            <end position="419"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="486"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5468975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="487" mass="53628" checksum="177C34FF621D7421" modified="2021-09-29" version="1">MRMVPLFLQRRLIAEVGSARRLRRLSLLACLTHEGRRHHANVPSTLHDPLGTPSNYEVISDPSSPVEVRVWRKGVDVERTATEQLHRISRMSPHIIPAPVAVMPDVHSGIGCTVGLVLPTVRAIIPACVGVDIGCGMIAVETSLTAEDLPNSLGDLRLAIELGVPHGRTHGGRGAADAGSWRNGVPAHVQQVWKKHLANDFEELCRRQAQMERTNNLNHLGTLGTGNHFIELCLDDQQPRKHVWVMLHSGSRGVGNRIGSVFIELAKKDMESRMIHLPDADLAYLGEGTEHFSDYIFAVEWAQKYAWWNRQLMLDAVLAAMRGCIKTPFITVNTAVNCHHNYVERIRIPIRERPHEGYAANSPDRETFREQDVWLTRKGATSARMGELAVIPGSMGACSYIVRGKGSVASYCSCSHGAGRRYSRGEARRRFTVADHEAATVGIECRKDSGVLDETPAAYKSIGAVIAAQDDLVDVVAVLQQVLCVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GQ15</accession>
    <name>A0A836GQ15_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7759 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_03385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060944.1">
        <property type="nucleotide sequence ID" value="XM_067205392.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92359326"/>
    <dbReference type="KEGG" id="loi:92359326"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056661">
        <property type="entry name" value="DUF7759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38758:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38758">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24945">
        <property type="entry name" value="DUF7759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7759" evidence="2">
        <location>
            <begin position="1203"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="541"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="715"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="784"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="837"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="876"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="967"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="998"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="274"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="336"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="556"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="720"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="883"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="967"/>
            <end position="981"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5471827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1310" mass="135444" checksum="1513C0D2C2617106" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GQS0</accession>
    <name>A0A836GQS0_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_07378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000008">
        <property type="protein sequence ID" value="KAG5486447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065513.1">
        <property type="nucleotide sequence ID" value="XM_067209270.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92363204"/>
    <dbReference type="KEGG" id="loi:92363204"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="541"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="731"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1070"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1375"/>
            <end position="1396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1464"/>
            <end position="1486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1505"/>
            <end position="1540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1573"/>
            <end position="1595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1860"/>
            <end position="1959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="617"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="1511"/>
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        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1935"/>
            <end position="1948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1949"/>
            <end position="1959"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5486447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1959" mass="210546" checksum="321E4BF960A31809" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GR59</accession>
    <name>A0A836GR59_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome c oxidase assembly factor 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_02990</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060561.1">
        <property type="nucleotide sequence ID" value="XM_067205009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GR59"/>
    <dbReference type="SMR" id="A0A836GR59"/>
    <dbReference type="GeneID" id="92358943"/>
    <dbReference type="KEGG" id="loi:92358943"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042775">
        <property type="term" value="P:mitochondrial ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008535">
        <property type="term" value="P:respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.140">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042289">
        <property type="entry name" value="COA6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048280">
        <property type="entry name" value="COX6B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036549">
        <property type="entry name" value="CX6/COA6-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46690">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46690:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02297">
        <property type="entry name" value="COX6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47694">
        <property type="entry name" value="Cytochrome c oxidase subunit h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5470295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="71" mass="8541" checksum="40A9B00F5FA86BA9" modified="2021-09-29" version="1">MQNAKKREACYEARDTFHKCLDTLPEDPEKECGVQKKIFELSCPKSWVSYFEKQREREVILQLQVEQYKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GRZ1</accession>
    <name>A0A836GRZ1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperonin HSP60, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">groEL protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_02202</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061273.1">
        <property type="nucleotide sequence ID" value="XM_067204236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GRZ1"/>
    <dbReference type="SMR" id="A0A836GRZ1"/>
    <dbReference type="GeneID" id="92358170"/>
    <dbReference type="KEGG" id="loi:92358170"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000001">
        <property type="entry name" value="60 kDa chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000592">
        <property type="entry name" value="PRK00013.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009487">
        <property type="entry name" value="PRK12849.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009488">
        <property type="entry name" value="PRK12850.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009489">
        <property type="entry name" value="PRK12851.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45633">
        <property type="entry name" value="60 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0346">Stress response</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00069579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00080006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5472877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="538" mass="58172" checksum="F0708D6870C77AE0" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GS22</accession>
    <name>A0A836GS22_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_02248</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <location>
            <begin position="890"/>
            <end position="916"/>
        </location>
    </feature>
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            <end position="364"/>
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            <end position="420"/>
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            <end position="601"/>
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    <feature type="coiled-coil region" evidence="1">
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            <begin position="665"/>
            <end position="692"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5472922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="916" mass="100573" checksum="A2614EEC298259B3" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="3">RRM domain-containing protein</fullName>
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        <name evidence="1" type="ORF">LSCM4_02601</name>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <source>
            <dbReference type="EMBL" id="KAG5469203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="467" mass="49487" checksum="BD115EBA46184457" modified="2021-09-29" version="1">MSSPQGHQNVLVGAAAPRPPPAVMSATGYVTQQCNTNASTRPSMWGRCGGIMAPTVTPVATSLPLQQIARTVPHTNSSSACYADPATLLGTGSAGTAPFQVLASQQQQQQAERHTNFGEHVMAPPPLANLASESYNGKERALIFQLRGLPFATTREDVEAFLGNINYHRLDVGTLATGESSGNAFLELRDLRAAEQLGRLHNTIITVAADARAPARERPRPRYVEVLNADAIRREQVLRVDAHTPRSALPQQRRARTAAAAGPATNIASFIGASTEPPPPQRPLVAFAEGDVRCFAAPTVTLPSRSSALMPPAPSQRFMEWPYLGGSSGMSWSAYAPPPPQQPQSSPLLAPSMPAPHYLGPQAAAMTTSSIPAMLHVQNVEESGLVRGTTLAPLPLYQLVTPLAPQLQATSQQRVFTRSNVSYFVVAAVSAPSSTLAEAQNTYYVAATSSTQAAASSNYYYLDGSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GT23</accession>
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        <recommendedName>
            <fullName evidence="9">Coiled-coil domain-containing protein 135</fullName>
        </recommendedName>
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        <name evidence="7" type="ORF">LSCM4_08107</name>
    </gene>
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        <name type="scientific">Leishmania orientalis</name>
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        <lineage>
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            <taxon>Euglenozoa</taxon>
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            <taxon>Trypanosomatida</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">LSCM4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000005">
        <property type="protein sequence ID" value="KAG5487662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A836GT23"/>
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        <property type="component" value="Chromosome 5"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="CEPT76/DRC7_peptidase-like_dom"/>
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        <property type="entry name" value="DRC7/lobo"/>
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        <property type="entry name" value="DRC7_C"/>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
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        <source>
            <dbReference type="Pfam" id="PF24656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5487662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="921" mass="104576" checksum="0EC3011988EDB22A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GU30</accession>
    <name>A0A836GU30_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MORN repeat-containing protein</fullName>
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        <name evidence="3" type="ORF">LSCM4_00181</name>
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    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
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    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067202270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GU30"/>
    <dbReference type="SMR" id="A0A836GU30"/>
    <dbReference type="GeneID" id="92356204"/>
    <dbReference type="KEGG" id="loi:92356204"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Phosphatidylinositol 4-phosphate 5-kinase 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23084:SF262">
        <property type="entry name" value="FYVE-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23084">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="257"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5464740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="938" mass="101577" checksum="1C5F823AC2446E38" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GU50</accession>
    <name>A0A836GU50_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cilia- and flagella-associated protein 58 central coiled coil domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_00538</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058717.1">
        <property type="nucleotide sequence ID" value="XM_067202616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GU50"/>
    <dbReference type="SMR" id="A0A836GU50"/>
    <dbReference type="GeneID" id="92356550"/>
    <dbReference type="KEGG" id="loi:92356550"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049270">
        <property type="entry name" value="CFAP58_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32083">
        <property type="entry name" value="CILIA AND FLAGELLA-ASSOCIATED PROTEIN 58-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32083:SF45">
        <property type="entry name" value="FLAGELLAR ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21771">
        <property type="entry name" value="CFAP58_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cilia- and flagella-associated protein 58 central coiled coil" evidence="3">
        <location>
            <begin position="406"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="92"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="365"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="421"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="774"/>
            <end position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5465086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="845" mass="97865" checksum="941434CC3980997F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GUM9</accession>
    <name>A0A836GUM9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein root UVB sensitive/RUS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_02872</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RUS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060444.1">
        <property type="nucleotide sequence ID" value="XM_067204892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GUM9"/>
    <dbReference type="GeneID" id="92358826"/>
    <dbReference type="KEGG" id="loi:92358826"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006968">
        <property type="entry name" value="RUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054549">
        <property type="entry name" value="UVB_sens_RUS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12770:SF31">
        <property type="entry name" value="RUS FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12770">
        <property type="entry name" value="RUS1 FAMILY PROTEIN C16ORF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04884">
        <property type="entry name" value="UVB_sens_prot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Protein root UVB sensitive/RUS" evidence="7">
        <location>
            <begin position="157"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5470178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="598" mass="67076" checksum="5C4C6FE2374CD2AD" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GVB5</accession>
    <name>A0A836GVB5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_00259</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058449.1">
        <property type="nucleotide sequence ID" value="XM_067202348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GVB5"/>
    <dbReference type="SMR" id="A0A836GVB5"/>
    <dbReference type="GeneID" id="92356282"/>
    <dbReference type="KEGG" id="loi:92356282"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00065">
        <property type="entry name" value="FYVE_like_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="8"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="81"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="154"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="186"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5464818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="255" mass="27593" checksum="B4D6C903624CB296" modified="2021-09-29" version="1">MGKSSATSSPAQRCAECERSFGMTLWRHTCDVCRRTVCDDCAPRSTESVDATGATTKLRVCETCGTTGRRLCSTVGGNATIDSAQSTGIARPDPNSEAERERRARLIEERNKMQRSRGCPQRADSESGSRVAFASERPVLPAPAVSSAAPALSRASVSSPGASPPPLDSSGSPERLVNPALEAAMRRQQQQQARGRSAASLPEASMSSEKTRLLCEIEMLLAKHREDPPFGLRASDEVKLRGYLQFLKKKYCMNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GVD4</accession>
    <name>A0A836GVD4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_06407</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000019">
        <property type="protein sequence ID" value="KAG5480839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063840.1">
        <property type="nucleotide sequence ID" value="XM_067208328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GVD4"/>
    <dbReference type="SMR" id="A0A836GVD4"/>
    <dbReference type="GeneID" id="92362262"/>
    <dbReference type="KEGG" id="loi:92362262"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000146">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KLP-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972:SF28">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KLP-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3 4" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VHS" evidence="8">
        <location>
            <begin position="57"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Kinesin motor" evidence="7">
        <location>
            <begin position="508"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="284"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="332"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="284"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="589"/>
            <end position="596"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5480839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="846" mass="93881" checksum="1D763B8EACF8D300" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GVG6</accession>
    <name>A0A836GVG6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C-CAP/cofactor C-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_00339</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBCC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058524.1">
        <property type="nucleotide sequence ID" value="XM_067202423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GVG6"/>
    <dbReference type="SMR" id="A0A836GVG6"/>
    <dbReference type="GeneID" id="92356357"/>
    <dbReference type="KEGG" id="loi:92356357"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1250">
        <property type="entry name" value="Tubulin Binding Cofactor C, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006599">
        <property type="entry name" value="CARP_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027684">
        <property type="entry name" value="TBCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038397">
        <property type="entry name" value="TBCC_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012945">
        <property type="entry name" value="Tubulin-bd_cofactor_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15139">
        <property type="entry name" value="TUBULIN FOLDING COFACTOR C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15139:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07986">
        <property type="entry name" value="TBCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00673">
        <property type="entry name" value="CARP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="6">
        <location>
            <begin position="126"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="314"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="323"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5464893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="341" mass="37696" checksum="6A6B9162093610E6" modified="2021-09-29" version="1">MEEKFLKLRQEREEQRRQRSKETVAITVQRQQFEAEAELLEAQVSQLLQDGNVGESQQRIDALRALVQDTSNSISLTAHEMAKANVILSRLQQLIDEKRSSAAPKKFKFSSRLKAKPTSDIELSTPSVSPSGTSDANGASAMAFVPDTGTVSSARGFGNVYGSYTGTDLFISHSRSVFVKDCVNCTIHCLPIAGSVFLTSCANCRVYVACHQLRLKSCTNLDLYAWCASTPIIETCDAMRFGPYRCWMGLLRSCTEDGRAFATHAEWVRSVGEIEDTARTEQNYVKVDDFQWVKKSASPHWRVLTREEEKVSTTVFGPATRPSSSSADVTAAAADGVVEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GVK0</accession>
    <name>A0A836GVK0_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061076.1">
        <property type="nucleotide sequence ID" value="XM_067204039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GVK0"/>
    <dbReference type="GeneID" id="92357973"/>
    <dbReference type="KEGG" id="loi:92357973"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5472680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="413" mass="44090" checksum="5F3693E8774447D0" modified="2021-09-29" version="1">MSGFWSFRESGADSAAVAGSAKGRRQLDLAVTQVLPVGVEFKRATLSTAHEDAHARFWMRAFPCAEAAGWIGGGDCAPVKKLVRQGDRSSSQSTSAEADDAVAVEEGGTNAHLVDRDEVIDAVQRKWWEALKADVRPGSLLPSASTAPAKVSTPDSETMDLVQDLLSHASGSAPSKAAARLHDSALLPCKVRLSERKKQRACLGRSPASDAQMISRKCSENTASCGFRSTVPRGPLLHTEQLARLRERRGSTTAVQHSEGGLGKSKTGDCSHHDQGGAAKGSIVASHLSLRPEGECSVEGKTSTGISTFATLDAQGEVLLPSEVLQGVLRTHTKGLTLSSTTATGVEAVRRREELLLLRHYFASWLAAASQRHNQQCATSYHCFLMQCIDETLGSTASRVKEEGIHDHGRSVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GVM8</accession>
    <name>A0A836GVM8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Small nuclear ribonucleoprotein E</fullName>
            <shortName evidence="9">snRNP-E</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Sm protein E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_02048</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061121.1">
        <property type="nucleotide sequence ID" value="XM_067204084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GVM8"/>
    <dbReference type="SMR" id="A0A836GVM8"/>
    <dbReference type="GeneID" id="92358018"/>
    <dbReference type="KEGG" id="loi:92358018"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01718">
        <property type="entry name" value="Sm_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000083">
        <property type="entry name" value="Small nuclear ribonucleoprotein E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027078">
        <property type="entry name" value="snRNP-E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11193">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="19"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5472725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="88" mass="10081" checksum="97102017C9203A29" modified="2021-09-29" version="1">MMSSAHTRQMENPTGVVHRFMQDHQRVCVWLVHETQTRLEGNLLGYDEFMNIVLGDTTETNLRTSKSYRLGKILLRSDNVGVIHPIGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GW22</accession>
    <name>A0A836GW22_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioredoxin-like fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000016">
        <property type="protein sequence ID" value="KAG5482356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064362.1">
        <property type="nucleotide sequence ID" value="XM_067207548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GW22"/>
    <dbReference type="SMR" id="A0A836GW22"/>
    <dbReference type="GeneID" id="92361482"/>
    <dbReference type="KEGG" id="loi:92361482"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="309"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5482356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="582" mass="63146" checksum="FA7624A442250FFB" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GXN7</accession>
    <name>A0A836GXN7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_03199</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">LSCM4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060765.1">
        <property type="nucleotide sequence ID" value="XM_067205213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GXN7"/>
    <dbReference type="SMR" id="A0A836GXN7"/>
    <dbReference type="GeneID" id="92359147"/>
    <dbReference type="KEGG" id="loi:92359147"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
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    <feature type="chain" id="PRO_5046529387" description="GOLD domain-containing protein" evidence="8">
        <location>
            <begin position="25"/>
            <end position="208"/>
        </location>
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        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
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            <begin position="29"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
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        <source>
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            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5471648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="208" mass="23393" checksum="AD11B898D8DE7AA7" modified="2021-09-29" version="1">MRRGALLPAPALVLLLAALAATVAVPLYGIRVDVEAAEVFSCSEAVPPGHVVMFSFLMNPDFVFPVRIRDVDTKELLKVWSNDAQGFFSVVSAEKKLQLAFEFDNAQSILTPMSVNFDIRVVPDLSSTVGAEQIDPIEQKIRTLSTKMYSLRSLQDALRYRQKDHRTTVEQVRRRVLLWSVLQVVGFLAALGGQLWLFRSFVEKRRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="4">60S ribosomal protein L7</fullName>
        </recommendedName>
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    <gene>
        <name evidence="2" type="ORF">LSCM4_07025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000018">
        <property type="protein sequence ID" value="KAG5481314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524:SF40">
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5481314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="34307" checksum="819BE2166033D69D" modified="2021-09-29" version="1">MGKNPPKWLPGERVKETILLQRRSVEQLRADRVLRKDKLQERRDRHKSKLDAKRKRRLSTKKFVSAQTILKHAQRKEKQGRTFQKIGEKVEGRRRHAHFGELKKRLHESPVRLVVRAKGSQIPPEVASAFKKLGLLKIYSARLISLTPRTEKLIEQLTPFSIVGEPDRAQLESLLRTRASLYNEETQTKRLISGNLLLEQALGQYNVLCIEDLVETIATNGEHVEEVLRHIAPFDFHPPRQLFVERHRSVHQKLEIVNKDSFAAYLSDQLQLTAKKQRKAAATAKKSKTARVKRKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GYS9</accession>
    <name>A0A836GYS9_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_04935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000014">
        <property type="protein sequence ID" value="KAG5483781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064720.1">
        <property type="nucleotide sequence ID" value="XM_067206911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GYS9"/>
    <dbReference type="GeneID" id="92360845"/>
    <dbReference type="KEGG" id="loi:92360845"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5483781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="419" mass="46167" checksum="6DD10FD7D52A0923" modified="2021-09-29" version="1">MEAIVAPAQAPSEARAHSPDAVQCRKCSEGERTAPWSLLPPLLLLVVLVLLFPLSGTSVSCAAGRCDISGLRLCRGAHLTRSAVTPVYGAGKKDSCTARPRVTAVPQVLMALAATADSLTDDSDEESEGADTWGTIAAKRNLDYDSGLKPFMAPWREVRRALRDMGCFSTLALPRLRLPTDTATPRLSDAAPEVSTAIPPLCRKPLVLMSGRGRNCASCSSFASDVLGHFQAEWEFIRAHVTLVDAGDPMTEELMRSPYPLWYDSAEMEQWLTLTEIPKERWADDDVAAAAPGSDSTSGASSYHMAQTLPESDAEDFTFFNTGFRHKAALLLLAPTSQTTRQWSRHVKRAFAGQSEYVLRIVFAYPHNGSVMRDIVNEEMTLSESRADYLHFFNKALPFFHCVKKAVRVMDWLQRYGDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H0X4</accession>
    <name>A0A836H0X4_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
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            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059740.1">
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    </dbReference>
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    <dbReference type="SMR" id="A0A836H0X4"/>
    <dbReference type="GeneID" id="92357024"/>
    <dbReference type="KEGG" id="loi:92357024"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="85"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="152"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5467938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="191" mass="22153" checksum="E50A05D9F184F023" modified="2021-09-29" version="1">MYSEVEQVSLVDQQFPECADVEEDERVRQSECINMNLVALNEMLRQLDCAGDKDGHGADCSRDAFTSMSASCLPPEIVDSLLHYLLKEQEGVQQLAARAELLEKQRMRDTEKAELLRERTEKLKNAVACMSARSSADMKEFRDYMQQNASANKQRQRELVDLTRKREKLELEVKRARMEVDRLRKIAKRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H238</accession>
    <name>A0A836H238_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
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        <location>
            <begin position="160"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5468955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="372" mass="41036" checksum="D4E7202CA7EFF607" modified="2021-09-29" version="1">MSGHRGVVGYSKMVDYYDSDYVPYDLLARCHTLQVELRKRREQQLSALSQGSGFAVDDDDAAVAPSLAQLRAHSSSSSRCVNQHQQQVLPWSMRSPHRVMRRGSNSLGERASGVQRMSRRGSTNGNIPRRSLVLEETYAARERSRSGAFGGGTLAHDSGAYGSSARRNASSSASSSSGALPDSARQGCNRQKARRRRLPTKAKNEALTSSDPYEAAAEARRQEQFLSENKRLGKPFVPSGNSGLGVPTRFMLGDCVKMLYRSIAPDWQVATPVVVSTAEDLIAIYFSLAKLSKEQVTALLQYMNGCLKHNDAVREFNLSKVDEGWDVLTNDGHILYTLRPPWVKKRAFLPYTVTPPHAHMRYGGKREGGKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H331</accession>
    <name>A0A836H331_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_07677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000012">
        <property type="protein sequence ID" value="KAG5484904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065016.1">
        <property type="nucleotide sequence ID" value="XM_067209556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H331"/>
    <dbReference type="GeneID" id="92363490"/>
    <dbReference type="KEGG" id="loi:92363490"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="564"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="881"/>
            <end position="900"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="202"/>
            <end position="219"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="579"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="657"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="726"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="743"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5484904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1182" mass="125586" checksum="75CE90B52D8E44E3" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H3W7</accession>
    <name>A0A836H3W7_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_04352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062546.1">
        <property type="nucleotide sequence ID" value="XM_067206337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H3W7"/>
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    <dbReference type="GeneID" id="92360271"/>
    <dbReference type="KEGG" id="loi:92360271"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5477135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="474" mass="53824" checksum="AE55C8FA023F57F0" modified="2021-09-29" version="1">MRLTFPLAKISPVPTRSVALSSSAAYHPRYALPRRMTLSSSFNTVTDKNRFTSLDLLLQKLSSYVGRRQYKMASDLTQSLEQFKRLGIDWHELKFLQRGELLELLSGQLQLNHAERAVLLTAVDAKVCGVLCRDTTRHSTRLCMNPGVADHGWRCGQDGHTNDVYFEGKEQANPAVLHLAHRSASRVARRDGIDVEVRHEPDFTIVGRNSVELNPRIWNPPEHSTFVVTPIGFEFRVHPDDPRAVHQIEEAASEWELHLGVMQQVIAEVLELYAVERDEQPLHLVPGELGEPDVPEVYSSAFHARRSSSSHTEAGSPITEHRMTSASGAERPWFQTPMPQRFTGGVPELLPFSPTIILHSSFRNIERDLSSADVNRRLMQPVVDISCFVHPNACFWWNAEEETRSTRLILDYAKRMPFALPFNLYFRVDPAKVLRAKPALVDERESLLRAKSPLFDLRRFRSVARTGEGEWGDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H3Z3</accession>
    <name>A0A836H3Z3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_07910</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000013">
        <property type="protein sequence ID" value="KAG5484344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064837.1">
        <property type="nucleotide sequence ID" value="XM_067209787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H3Z3"/>
    <dbReference type="GeneID" id="92363721"/>
    <dbReference type="KEGG" id="loi:92363721"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="41"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="205"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="229"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5484344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="619" mass="68321" checksum="6733E3F15B30A0FC" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H439</accession>
    <name>A0A836H439_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ethanolamine-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="10">2.7.7.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">CTP:phosphoethanolamine cytidylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LSCM4_02759</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>phosphoethanolamine + CTP + H(+) = CDP-ethanolamine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:24592"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:57876"/>
            <dbReference type="ChEBI" id="CHEBI:58190"/>
            <dbReference type="EC" id="2.7.7.14"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:24593"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.14" evidence="10"/>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060331.1">
        <property type="nucleotide sequence ID" value="XM_067204779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H439"/>
    <dbReference type="SMR" id="A0A836H439"/>
    <dbReference type="GeneID" id="92358713"/>
    <dbReference type="KEGG" id="loi:92358713"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00742"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004306">
        <property type="term" value="F:ethanolamine-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02174">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02173">
        <property type="entry name" value="ECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000249">
        <property type="entry name" value="Ethanolamine-phosphate cytidylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000108">
        <property type="entry name" value="Ethanolamine-phosphate cytidylyltransferase isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041723">
        <property type="entry name" value="CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044608">
        <property type="entry name" value="Ect1/PCYT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780">
        <property type="entry name" value="ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780:SF2">
        <property type="entry name" value="ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="15">
        <location>
            <begin position="57"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Cytidyltransferase-like" evidence="15">
        <location>
            <begin position="237"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00071269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG5470065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="404" mass="45497" checksum="D31CBF87ABBA1A37" modified="2021-09-29" version="1">MATVRSSSVTPSPATTPTVRVPPGKVWLNSDEPNDEYPLFCTEPIPPKKTGTVRVWVDGCFDMLHFGHANALRQARRLGAELFVGCHSDEEVMRFKGPPIMHAEERYEALRACKWVDYVVENYPYCTRLKDVERFDIDYVVHGDDISVGLDGRNSYQEIIDAGKFKVVKRTEGISTTDLVGRMLLCTKNHMLKSVDEVQLENCLFEHSPTMHYLTTSRKIVQFSNNTSPKSGDRIVYVDGSFDLFHIGHIRVLQRARELGDYVIAGVYEDQVVNEQKGKNYPIMNLNERVLGVLSCRYVDEVVMGVPLDVSKEVIDGLHINVVVSGKFSDAAVEQAGSTAYKVPKAMGIYHEVDSGCTLSTDSLIDRVVANRLAFLKRQAKKLLTDKKSQESKPEEYRNVQEVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H4Q8</accession>
    <name>A0A836H4Q8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Myosin heavy chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_03076</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060646.1">
        <property type="nucleotide sequence ID" value="XM_067205094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H4Q8"/>
    <dbReference type="SMR" id="A0A836H4Q8"/>
    <dbReference type="GeneID" id="92359028"/>
    <dbReference type="KEGG" id="loi:92359028"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14875">
        <property type="entry name" value="MYSc_Myo13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14291">
        <property type="entry name" value="UBA1_NUB1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000011">
        <property type="entry name" value="Myosin 10A, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.4820:FF:000016">
        <property type="entry name" value="Myosin XXI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000154">
        <property type="entry name" value="Myosin XXI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036125">
        <property type="entry name" value="MYSc_Myo21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF706">
        <property type="entry name" value="DILUTE CLASS UNCONVENTIONAL MYOSIN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6" id="KW-0518">Myosin</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="9">
        <location>
            <begin position="61"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="8">
        <location>
            <begin position="951"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="8">
        <location>
            <begin position="1009"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="6">
        <location>
            <begin position="622"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="768"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="157"/>
            <end position="164"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5470380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1050" mass="119017" checksum="3179C542DCF6D4BE" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H5H7</accession>
    <name>A0A836H5H7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_05355</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5477960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062867.1">
        <property type="nucleotide sequence ID" value="XM_067207299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H5H7"/>
    <dbReference type="GeneID" id="92361233"/>
    <dbReference type="KEGG" id="loi:92361233"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 245"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="675"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="730"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="758"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="290"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="575"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="949"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="315"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="957"/>
            <end position="968"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5477960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="968" mass="105102" checksum="82D00C34A14A2F30" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H7K0</accession>
    <name>A0A836H7K0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine/threonine-protein phosphatase 4 regulatory subunit 3-like central domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_03408</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">LSCM4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060967.1">
        <property type="nucleotide sequence ID" value="XM_067205415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H7K0"/>
    <dbReference type="SMR" id="A0A836H7K0"/>
    <dbReference type="GeneID" id="92359349"/>
    <dbReference type="KEGG" id="loi:92359349"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030289">
        <property type="term" value="C:protein phosphatase 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072542">
        <property type="term" value="F:protein phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006887">
        <property type="entry name" value="P4R3-like_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051137">
        <property type="entry name" value="PP4R3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318">
        <property type="entry name" value="ATP SYNTHASE GAMMA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04802">
        <property type="entry name" value="PP4R3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine-protein phosphatase 4 regulatory subunit 3-like central" evidence="4">
        <location>
            <begin position="185"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="868"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="886"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="966"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="976"/>
            <end position="987"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5471850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="987" mass="105975" checksum="AF2CFA4FE51C6F11" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H7T7</accession>
    <name>A0A836H7T7_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000022">
        <property type="protein sequence ID" value="KAG5479175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063268.1">
        <property type="nucleotide sequence ID" value="XM_067203809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H7T7"/>
    <dbReference type="GeneID" id="92357743"/>
    <dbReference type="KEGG" id="loi:92357743"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5479175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1108" mass="122429" checksum="B96F23CDCF24526B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H839</accession>
    <name>A0A836H839_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_08019</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000005">
        <property type="protein sequence ID" value="KAG5487574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065862.1">
        <property type="nucleotide sequence ID" value="XM_067209895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H839"/>
    <dbReference type="SMR" id="A0A836H839"/>
    <dbReference type="GeneID" id="92363829"/>
    <dbReference type="KEGG" id="loi:92363829"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5487574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="442" mass="47301" checksum="D9581058863DD463" modified="2021-09-29" version="1">MPSSARKKKDKVPAPGTKGDAFTGFYTKKKWKSVLQETRVDLAGRALRPRGALIVGTALLKNTYVTWLDLSQNDLGDDGAIAIASMLRANTQVQHLNLSHNGMTDVGGIALASAFIPNVSPSGQPGQWNRTLFSLVLMGNNLGDDTLLAMGNAAACHRDLTRVDLSWNTIGQNGPKSLMRAYQRNPLCVYQLAANALGDEGTVYLCEALQRHGGKSQTTLNLYRNSISCLGAEAVGRLLANTSIVQDVSLAGNTIGFKGVQALQRQLTDAAVMASLSLRFLNLSDNWIGDEGAASVAAIIKADLPSLERLDVSANKITDIGATAIVAAALHNTHLLLLNCEENRLGRKAVEAVVRLIHETRTLKSLNVTGCVDSADHRRALTIAVGENDGLHVELGPNPPDAAGAEDVALIDKVTEHLQMLADQEAQRQKESIVKKRLKKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H9J1</accession>
    <name>A0A836H9J1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_02180</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061251.1">
        <property type="nucleotide sequence ID" value="XM_067204214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H9J1"/>
    <dbReference type="SMR" id="A0A836H9J1"/>
    <dbReference type="GeneID" id="92358148"/>
    <dbReference type="KEGG" id="loi:92358148"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000011">
        <property type="entry name" value="Replication factor C subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000129">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF20">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="58"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5472855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="354" mass="38502" checksum="B2C3AAE1A81F05C2" modified="2021-09-29" version="1">MRSSSQPAQKKAKTEGTADTAAAAAPWVEKYRPRTLAEVQAQDEAVSALRACLKEGTNMPHFLFHGPPGTGKTTSILAVAHELFGPDYIRSRVRELNASDDRGISVVREKVKIFAQGAVSSTGSSVTQSDGKVYPVPPFKLIILDEADALLPDAQGALRRMMEDFSDVTRFCILCNYVSRIIDPIASRCAKYRFKPLVKSALYQRIEYVAQAEGITLSPSSLHALDAVSGGDLRLAIMHLQSAQKANGNDLTKEDFVSVSGSVPADGMQQYISALLSHRLEEVIQASRRLVAEGFAAAQVLIQLQRYLVSTECPLNSAQRGRIMLKLCQTERRLADGADDYLQLLDIGSAVCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H9J7</accession>
    <name>A0A836H9J7_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_07819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000006">
        <property type="protein sequence ID" value="KAG5487329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065826.1">
        <property type="nucleotide sequence ID" value="XM_067209696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H9J7"/>
    <dbReference type="GeneID" id="92363630"/>
    <dbReference type="KEGG" id="loi:92363630"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="556"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="647"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="223"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="355"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="585"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="666"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5487329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="924" mass="99041" checksum="2D5BCA51FA93A033" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H9K8</accession>
    <name>A0A836H9K8_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Bates M.D."/>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
            <dbReference type="EMBL" id="KAG5483060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="697" mass="72190" checksum="19C5630448562F39" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HG94</accession>
    <name>A0A836HG94_9TRYP</name>
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        <recommendedName>
            <fullName evidence="11">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_05197</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the exportin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_067207148.1"/>
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    <dbReference type="KEGG" id="loi:92361082"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="ARM-type_fold"/>
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        <property type="entry name" value="XPO4/7-like"/>
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        <property type="entry name" value="EXPORTIN 4,7-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="EXPORTIN-7 ISOFORM X1"/>
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    </dbReference>
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        <property type="entry name" value="ARM repeat"/>
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    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
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        <location>
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            <end position="1115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
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            <begin position="1097"/>
            <end position="1111"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5476218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1221" mass="133842" checksum="C2D1FA4C7E6CCD18" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HIF1</accession>
    <name>A0A836HIF1_9TRYP</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">LSCM4_06955</name>
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        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000017">
        <property type="protein sequence ID" value="KAG5481878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064238.1">
        <property type="nucleotide sequence ID" value="XM_067208864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HIF1"/>
    <dbReference type="SMR" id="A0A836HIF1"/>
    <dbReference type="GeneID" id="92362798"/>
    <dbReference type="KEGG" id="loi:92362798"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5481878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="732" mass="77282" checksum="7C3B06469E33ED72" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HIN7</accession>
    <name>A0A836HIN7_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_07615</name>
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    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
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        <lineage>
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            <taxon>Kinetoplastea</taxon>
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            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000012">
        <property type="protein sequence ID" value="KAG5484845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_067064957.1">
        <property type="nucleotide sequence ID" value="XM_067209497.1"/>
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        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
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    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="526"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="574"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="599"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="663"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5484845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HJS0</accession>
    <name>A0A836HJS0_9TRYP</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05505</name>
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    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5478105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063012.1">
        <property type="nucleotide sequence ID" value="XM_067207444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HJS0"/>
    <dbReference type="SMR" id="A0A836HJS0"/>
    <dbReference type="GeneID" id="92361378"/>
    <dbReference type="KEGG" id="loi:92361378"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5478105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="293" mass="32531" checksum="5ACAFAF114E09FE3" modified="2021-09-29" version="1">MSAAAVAAAASPRPPSSALYTERLFYAALKQGNPSETRVEALAALALRHLPKSAETWAALRKALMEQSDLDGAPNRTLWYVLDALMKHAPHVFVPLLAPRLLEYTIQQLPWELAGHRGQTLLWFEALVLSWEKVLPQRLYSAIRQHAVQSRSGAELHDLLEAAQSTADDGTPASVTDMQQLRDAWDAVQYMGEQEAGKSVFYARHITAALEVEDEAALVNGLHVPGPGNRGRMAGADISDDDVAKTEEQQEEDEYTPDFVEGAKPRELPKLDLPKPKRRREGRRRPREDDLGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HLV8</accession>
    <name>A0A836HLV8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Elongation of fatty acids protein</fullName>
            <ecNumber evidence="12">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LSCM4_04891</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>an acyl-CoA + malonyl-CoA + H(+) = a 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:50252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:50253"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="12"/>
    <dbReference type="EMBL" id="JAFHLR010000014">
        <property type="protein sequence ID" value="KAG5483738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064677.1">
        <property type="nucleotide sequence ID" value="XM_067206868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HLV8"/>
    <dbReference type="GeneID" id="92360802"/>
    <dbReference type="KEGG" id="loi:92360802"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF17">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG5483738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="305" mass="33736" checksum="D172217AA2F1A78D" modified="2021-09-29" version="1">MMPHFIEWIVNFDGYPLQAFLLENIDVIGYIASLYLVMVGKGDRILSWWNKRKAPAANSAAKQNGPSKETVAAIKACDAAASIYHLLVCIACAAVSCLLVPAMAQSVLANSFFQTMCFLDDARVYKGYVSFALGAAVMVKVAEQLDTFFLILRDYIAASSTQEKGVRWVQPSHWWFQVLVSLYFWHTYSIGTSCFAMIVTLTMVISAARNFVYMQQDAAQAHGKTAVAAKRNGALVALDMTEWVGCSALSVYASYMNYTDKRGCMTMQANVRMALVMYVTAVVLRLRELCKDAAAPGALQSKRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HVA1</accession>
    <name>A0A836HVA1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">HSP70-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_08361</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000001">
        <property type="protein sequence ID" value="KAG5488283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066330.1">
        <property type="nucleotide sequence ID" value="XM_067210229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HVA1"/>
    <dbReference type="GeneID" id="92364163"/>
    <dbReference type="KEGG" id="loi:92364163"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034663">
        <property type="term" value="C:endoplasmic reticulum chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF3">
        <property type="entry name" value="HYPOXIA UP-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="911"/>
            <end position="966"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5488283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1106" mass="116565" checksum="07DB797187540CFA" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HZG8</accession>
    <name>A0A836HZG8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_05957</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000011">
        <property type="protein sequence ID" value="KAG5485323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065060.1">
        <property type="nucleotide sequence ID" value="XM_067207886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HZG8"/>
    <dbReference type="SMR" id="A0A836HZG8"/>
    <dbReference type="GeneID" id="92361820"/>
    <dbReference type="KEGG" id="loi:92361820"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03755">
        <property type="entry name" value="proteasome_alpha_type_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000004">
        <property type="entry name" value="Proteasome subunit alpha type-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 3 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="5">
        <location>
            <begin position="3"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5485323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="247" mass="27762" checksum="B09B30E81E55CFA6" modified="2021-09-29" version="1">MSYDRAITVFSPDGHLFQVEYAQEAVKKGLAAVGVLGSDCVVIAVEKKSAVKLQDSRTIRKIYKVDAHIYLAFAGLSADARVLINKAQLECQRFALNYEDTMDVDMLVRYVAGVQQKSTQSGGSRPFGVATVIGGFNEDGKPHLWKTDPSGMSSAWRAVAIGRHDQTVIDFMEKSYRDGMSRDECVHFAIKSLLEVVESGSRNIELLVLQYKDERYLTEEELQKFVVEVEKEREEEAAKKKRQAEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836I2G1</accession>
    <name>A0A836I2G1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_06273</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAFHLR010000007">
        <property type="protein sequence ID" value="KAG5486808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065602.1">
        <property type="nucleotide sequence ID" value="XM_067208197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836I2G1"/>
    <dbReference type="GeneID" id="92362131"/>
    <dbReference type="KEGG" id="loi:92362131"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001566">
        <property type="entry name" value="Protein_kinase_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051131">
        <property type="entry name" value="NEK_Ser/Thr_kinase_NIMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899">
        <property type="entry name" value="CAMK FAMILY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="6"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="187"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="248"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="571"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="275"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="571"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="592"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5486808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1035" mass="112198" checksum="F072A87012931455" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836I3M9</accession>
    <name>A0A836I3M9_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_07458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000004">
        <property type="protein sequence ID" value="KAG5487780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065977.1">
        <property type="nucleotide sequence ID" value="XM_067209345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836I3M9"/>
    <dbReference type="SMR" id="A0A836I3M9"/>
    <dbReference type="GeneID" id="92363279"/>
    <dbReference type="KEGG" id="loi:92363279"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38019">
        <property type="entry name" value="KDA ANTIGEN P200, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38019:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="248"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="305"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5487780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="505" mass="56221" checksum="F1A597E3EFF94859" modified="2021-09-29" version="1">MSFPGAIETQEPSSLEAQLTAPDPLSHQMHQKSPREDEEEDPCEAVPRGTCKPSAVPAHVYVEGSDEEAAATSPVNGESEGEKLHEAAGAAPRGGAAPAELIRTARPRDVNRAKKVKKPANHAKEVKAAKPAKPAAPRKTKPTLKVNIGNVDRQPPIPEGVNSPRSVALCKEQGVNPSELTPYTKEHFKGAGVSDELAELRYQSYEKRRRARMAQLLPAYKERAKADADYCVPFSAAKRKAHVDEEASAQSAAAEQATAQLSKPMDEEAEMQRQFEAQHQRLLEQERRKTMTSGYDSNGRRRSPPRSGQSYGPSVRSVGSAKSPGRYSMGTSVGARPTVGQPYSAAKIYSASIVENRPLTQGEAMMIDEINEREAHRIDTQERAFVIQENKQLMHVERELMRERHASMRVQKNAEDRRKMQMEMYRRTQSRQQEVAERRKQLEMERHTRIRNSISEKDGRIHTLDRYASLVARQMSGFSSRRTSRSIQSQGANASASLEQPEVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836I436</accession>
    <name>A0A836I436_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase DHHC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_08244</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000003">
        <property type="protein sequence ID" value="KAG5488020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066147.1">
        <property type="nucleotide sequence ID" value="XM_067210114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836I436"/>
    <dbReference type="SMR" id="A0A836I436"/>
    <dbReference type="GeneID" id="92364048"/>
    <dbReference type="KEGG" id="loi:92364048"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF85">
        <property type="entry name" value="PALMITOYLTRANSFERASE HIP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="415"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="502"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="612"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="711"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="112"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="145"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="286"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5488020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1020" mass="113056" checksum="0D6E7D622F1041B0" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836K994</accession>
    <name>A0A836K994_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_01091</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5468004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059806.1">
        <property type="nucleotide sequence ID" value="XM_067203156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836K994"/>
    <dbReference type="GeneID" id="92357090"/>
    <dbReference type="KEGG" id="loi:92357090"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032269508" evidence="3">
        <location>
            <begin position="25"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5468004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="106" mass="11108" checksum="C7D9354F35BF15FB" modified="2021-09-29" version="1">MSSMSKLVLSVAITMAAMAPPAVATTTMTAAPIPVSRGLNVVTTVLILGVSIAAALLFALWKLYPQICSGELTLSKIESRLRAGQRGQTPRKEKVHADEVSGADMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KBJ3</accession>
    <name>A0A836KBJ3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Shq1 protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_03070</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SHQ1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060640.1">
        <property type="nucleotide sequence ID" value="XM_067205088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KBJ3"/>
    <dbReference type="SMR" id="A0A836KBJ3"/>
    <dbReference type="GeneID" id="92359022"/>
    <dbReference type="KEGG" id="loi:92359022"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000493">
        <property type="term" value="P:box H/ACA snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000080">
        <property type="entry name" value="Protein SHQ1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039742">
        <property type="entry name" value="Shq1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048696">
        <property type="entry name" value="SHQ1-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007009">
        <property type="entry name" value="Shq1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12967">
        <property type="entry name" value="PROTEIN SHQ1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12967:SF0">
        <property type="entry name" value="PROTEIN SHQ1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04925">
        <property type="entry name" value="SHQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21413">
        <property type="entry name" value="SHQ1-like_CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHQ1-like CS" evidence="3">
        <location>
            <begin position="3"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Shq1 C-terminal" evidence="2">
        <location>
            <begin position="361"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5470374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="582" mass="63220" checksum="7532807ABD77C1B2" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KBP8</accession>
    <name>A0A836KBP8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nascent polypeptide-associated complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_00408</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Part of the nascent polypeptide-associated complex (NAC).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NAC-beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058591.1">
        <property type="nucleotide sequence ID" value="XM_067202490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KBP8"/>
    <dbReference type="SMR" id="A0A836KBP8"/>
    <dbReference type="GeneID" id="92356424"/>
    <dbReference type="KEGG" id="loi:92356424"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22055">
        <property type="entry name" value="NAC_BTF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.30:FF:000005">
        <property type="entry name" value="Nascent polypeptide-associated complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.30">
        <property type="entry name" value="Nascent polypeptide-associated complex domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039370">
        <property type="entry name" value="BTF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038187">
        <property type="entry name" value="NAC_A/B_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10351">
        <property type="entry name" value="TRANSCRIPTION FACTOR BTF3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01849">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01407">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NAC-A/B" evidence="4">
        <location>
            <begin position="34"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5464960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="103" mass="11692" checksum="50BD19BB6D6730B5" modified="2021-09-29" version="1">MPITQEQLKRRAEMVRTGGKGSMRRTTKAHHKSTGDDKKVQVALRRLGVTPFSDIDEAVFYRQDGSVYYFSKPKVQASMQTQCFVVSGDYEVKSAEEVDTKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KBR5</accession>
    <name>A0A836KBR5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2CD3 N-terminal C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_00911</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059628.1">
        <property type="nucleotide sequence ID" value="XM_067202978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KBR5"/>
    <dbReference type="GeneID" id="92356912"/>
    <dbReference type="KEGG" id="loi:92356912"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057537">
        <property type="entry name" value="C2_C2CD3_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25339">
        <property type="entry name" value="C2_C2CD3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2CD3 N-terminal C2" evidence="2">
        <location>
            <begin position="7"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="624"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="659"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5467826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="978" mass="105807" checksum="4F503398269053B0" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KCZ6</accession>
    <name>A0A836KCZ6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fumarylacetoacetase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_01426</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059170.1">
        <property type="nucleotide sequence ID" value="XM_067203479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KCZ6"/>
    <dbReference type="SMR" id="A0A836KCZ6"/>
    <dbReference type="GeneID" id="92357413"/>
    <dbReference type="KEGG" id="loi:92357413"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000027">
        <property type="entry name" value="Fumarylacetoacetate_(FAA)_hydrolase_family_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="30"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5466280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="274" mass="29983" checksum="F394473CBB800A40" modified="2021-09-29" version="1">MSSLAFTLRQTVVPVVTRNAKPLNFPVRRVYCAGQNYDSHAREMGCTINRMDQFFFLKPTDSIVTDLGNHKSPSATVNIRYPTLTESYHHEVELVVALGYPAGKTALSSAVAQGTDGVHYTNMKIEEAHDIIYAYGVGLDMTRRDLQLMAKENGRPWDLSKGADDATVVAPLVLSEDLRESHPEMFTTPDKDETNVVSCGSIFLQVNQNERQRGDLNCMVSPIAELIAHLSKYVALQPGDLLFTGTPSGVGAVRRGDVMEAGIQGLGTLKVNVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KEN9</accession>
    <name>A0A836KEN9_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_01122</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5468035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059837.1">
        <property type="nucleotide sequence ID" value="XM_067203187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KEN9"/>
    <dbReference type="SMR" id="A0A836KEN9"/>
    <dbReference type="GeneID" id="92357121"/>
    <dbReference type="KEGG" id="loi:92357121"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.20.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017943">
        <property type="entry name" value="Bactericidal_perm-incr_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032942">
        <property type="entry name" value="BPI/LBP/Plunc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504">
        <property type="entry name" value="BACTERICIDAL PERMEABILITY-INCREASING BPI PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504:SF131">
        <property type="entry name" value="BPI2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55394">
        <property type="entry name" value="Bactericidal permeability-increasing protein, BPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5468035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="539" mass="58893" checksum="C1D7C53CE5273B25" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KGC0</accession>
    <name>A0A836KGC0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Acetyl-CoA C-acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_03263</name>
        <name evidence="8" type="ORF">LSCM4_03264</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">LSCM4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060828.1">
        <property type="nucleotide sequence ID" value="XM_067205276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KGC0"/>
    <dbReference type="SMR" id="A0A836KGC0"/>
    <dbReference type="GeneID" id="92359210"/>
    <dbReference type="KEGG" id="loi:92359210"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050521">
        <property type="entry name" value="3-ketoacyl-CoA_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42689">
        <property type="entry name" value="ACETYL-COA ACYLTRANSFERASE FADA2 (3-KETOACYL-COA THIOLASE) (BETA-KETOTHIOLASE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42689:SF1">
        <property type="entry name" value="ACETYL-COA ACYLTRANSFERASE FADA2 (3-KETOACYL-COA THIOLASE) (BETA-KETOTHIOLASE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="5">
        <location>
            <begin position="6"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="6">
        <location>
            <begin position="191"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5471711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5471712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="35463" checksum="9FCA794DB93B40BB" modified="2021-09-29" version="1">MLVEGEHADVVIAGGSDSVSNAELPLPRSVTHGLMMAQRKGIMGFFKEAGYNPSRWLPSGVALTERSTGKTMGWHGDVIGELNSISREDQEALAVASHANAARAEKAGYFSDEIVPVMVDATKNIEVKCDDVLQRDTEKMKAKMPSLKPVFRKDKGTITAATSSALTDGGSAMLVMSEEKAKKLGYPTDVSVKSWYFCGIDPYPQLLLAPVLGWGPALRKAGLAPKDIDLYEIHEAFAAQVLATIKCLRSQEFFDRYAGGGKPLLTEDIDRSRLNVNGGSLALGHPFAATGGRIVTSLANELRRSGKRHGLVSICAAGGLGGVAVLEHTPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KGU9</accession>
    <name>A0A836KGU9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tubulin/FtsZ GTPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_00535</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058714.1">
        <property type="nucleotide sequence ID" value="XM_067202613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KGU9"/>
    <dbReference type="GeneID" id="92356547"/>
    <dbReference type="KEGG" id="loi:92356547"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02189">
        <property type="entry name" value="delta_zeta_tubulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="6">
        <location>
            <begin position="96"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="135"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5465083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="563" mass="61074" checksum="18053ADACE5DBC32" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KGZ4</accession>
    <name>A0A836KGZ4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial import inner membrane translocase subunit TIM50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_04298</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TIM50 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062222.1">
        <property type="nucleotide sequence ID" value="XM_067206285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KGZ4"/>
    <dbReference type="SMR" id="A0A836KGZ4"/>
    <dbReference type="GeneID" id="92360219"/>
    <dbReference type="KEGG" id="loi:92360219"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000282">
        <property type="entry name" value="TFIIF-stimulated CTD phosphatase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="1" id="KW-0811">Translocation</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="FCP1 homology" evidence="3">
        <location>
            <begin position="175"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5475714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="386" mass="43795" checksum="07FC527EED7FBF68" modified="2021-09-29" version="1">MHRRSCALLSSFGSWSPFGRPDRSGDVSGAKPRFGDGGSAPRDLFQKTALHRQSHYAVSAGGRGAASVPESPSTTRRKSYAEAAAGVLGTASSAARQEGVHMYANKENAWDGYTDDRFYGAKRFREYWQRMLADRGVRYYMFTIIVLMMAATAKLWQMQNLQRAESGLLGPRKKQYRSRLTIVLDVDETIVSYGDKAFRLKAGLVPRPYLAELLDYLSSIDAEVVLWSASSERYIRQVLGIIDPMGVRVSQYLSRSKEWFTGDNYYEKNILWLKRPLEDTLIIENRPLSVRNCNGNAILVDDFIRGEYMDTGQDYPANDHALRTVKNIVQDLETSGMSVPEYLANKKLRNREIREIPCHLAIRQLPEEIARGVFYFIGDKYKPRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KIN6</accession>
    <name>A0A836KIN6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_04255</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062179.1">
        <property type="nucleotide sequence ID" value="XM_067206242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KIN6"/>
    <dbReference type="SMR" id="A0A836KIN6"/>
    <dbReference type="GeneID" id="92360176"/>
    <dbReference type="KEGG" id="loi:92360176"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14016">
        <property type="entry name" value="STKc_CK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001132">
        <property type="entry name" value="Casein kinase I-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="105"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="175"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5475671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="566" mass="62514" checksum="68C989B07EC517FE" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KJX2</accession>
    <name>A0A836KJX2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_04224</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062150.1">
        <property type="nucleotide sequence ID" value="XM_067206213.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92360147"/>
    <dbReference type="KEGG" id="loi:92360147"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050397">
        <property type="entry name" value="Env_Response_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24567">
        <property type="entry name" value="CRP FAMILY TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24567:SF26">
        <property type="entry name" value="REGULATORY PROTEIN YEIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="535"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="733"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1070"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1097"/>
            <end position="1108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5475642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1354" mass="144683" checksum="E414E3E2BD1B480C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KKE2</accession>
    <name>A0A836KKE2_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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            <dbReference type="PubMed" id="34489462"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5477215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1232" mass="129046" checksum="4E507383E4EB911E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KPC9</accession>
    <name>A0A836KPC9_9TRYP</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">LSCM4_05297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG5477905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067207244.1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5477905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="289" mass="31902" checksum="2059499756C5FC6F" modified="2021-09-29" version="1">MTTLEKQLQSCTLSSQCKADLLNHVEEIEANSRRLPKKMITLPDPNLPSAVMMSTDNSVKRRDAAAAGGANMERSLRYTERKQEKDEMIASRTTSGTNPSGTYFKECSHKFMNGARSCSDPFRSSRSRTVLSGKDMDFVYRYASAATGSAIERPVPADEASIAATAAYREAFREYKGRDPTAKEMEESGRLIYAFDENGSVGVLQKPHSCYPHTHISASRTYVRACANQVYPPEAPPVRAARSEFPGPIPTWSSTKRTTTMATNGTYQPGHHQPTSLKREAMDTVVGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KPJ5</accession>
    <name>A0A836KPJ5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_03504</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061441.1">
        <property type="nucleotide sequence ID" value="XM_067205504.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92359438"/>
    <dbReference type="KEGG" id="loi:92359438"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ATP-binding cassette protein subfamily A, member 10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF36">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="362"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="407"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="442"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="470"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="499"/>
            <end position="522"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="534"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="665"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1074"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1270"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1312"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1351"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1381"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1420"/>
            <end position="1443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1463"/>
            <end position="1488"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="677"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1544"/>
            <end position="1773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5473438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1871" mass="207109" checksum="3EDCE902EFC49ED1" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KPL3</accession>
    <name>A0A836KPL3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_05515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5478115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063022.1">
        <property type="nucleotide sequence ID" value="XM_067207454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KPL3"/>
    <dbReference type="SMR" id="A0A836KPL3"/>
    <dbReference type="GeneID" id="92361388"/>
    <dbReference type="KEGG" id="loi:92361388"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
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            <end position="92"/>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="EMBL" id="KAG5478115.1"/>
        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="27178" checksum="0CB0933D43EA999E" modified="2021-09-29" version="1">MHPRTSGQGLFPRYGGGWMHQFGHVYALQQELLDPSANNWFRAVELWHTARQEGVAMNASHFTSILRQCVQPGAWAQSLQVLKQMKRESLRPDVVGVGCALAACVEGKHYAEVEDIFASFHKTMLLDSVCHLALIRARQESGNAKGAIAAGSQQQVEQVPFLPYTYTHLLEACNAEDDAAYAMELVRSMRSEQWAPSRIAVRAIQDLGRRHEELAAISRPLLSEGGKVDGALRLLDNSNHLPPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KRK5</accession>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="433" mass="50677" checksum="D21FFD2C23C945FD" modified="2021-09-29" version="1">MGILTKWYENLALEKRLELLMTLGMYDERVYEVVERHHLAPDILQTLPSPLTAHFLARGMCYDAVNEEVVRNFVRICMMLSRYRTVEEASTLAELIGSCGLPEQYRMQMFNFSETYRHMILSQSFFPQRAVLRLLSYIFCDDFLSDAVAQLQYKSDILNHVNKVYVTTPDFVSWRFSVRCMSLAGGFNEDRSDVEYTELLTRVVSQALPEFLSYFLVTFFYARFRLYPQRVRGITPRWLVRQRAGFSALYCAFLGVYCNFLLEYRVHEHRVLYELRKSRELRRRRAAERRGVPYDKNPYFDNLEGVTRRVYMMQLSAYTFTGLGLAVSMLPLTSVKFPKVMGDVAWRHPFVPRLFPALLGMHAASRCLIPFVVAPFTAVSLAKYGNWGTTLYDRYVEFRMRLWHRKVDVAFDTSTEVDEVDITGVDMAKKGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="3" type="ORF">LSCM4_07638</name>
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        <name type="scientific">Leishmania orientalis</name>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <location>
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            <end position="363"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5484866.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="694" mass="72070" checksum="F775B78E55A69D58" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KS65</accession>
    <name>A0A836KS65_9TRYP</name>
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        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
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    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
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                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067207203.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
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        <property type="entry name" value="Aur-like"/>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
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        <property type="entry name" value="Prot_kinase_dom"/>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
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            <end position="810"/>
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        </location>
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    <feature type="binding site" evidence="6 7">
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            <position position="572"/>
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        <ligand>
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    <feature type="binding site" evidence="6">
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        </location>
        <ligand>
            <name>ATP</name>
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    <feature type="binding site" evidence="6">
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            <position position="691"/>
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        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5476273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1195" mass="124099" checksum="72D55163F7877E86" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KS92</accession>
    <name>A0A836KS92_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_06413</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000019">
        <property type="protein sequence ID" value="KAG5480845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063846.1">
        <property type="nucleotide sequence ID" value="XM_067208334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KS92"/>
    <dbReference type="SMR" id="A0A836KS92"/>
    <dbReference type="GeneID" id="92362268"/>
    <dbReference type="KEGG" id="loi:92362268"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19851:SF7">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19851">
        <property type="entry name" value="OS02G0203500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="4">
        <location>
            <begin position="267"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="267"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="308"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="378"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5480845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="392" mass="42779" checksum="F0436A4417ABE997" modified="2021-09-29" version="1">MNAMSPFYGRMYPTQAAPLLWEATQTLQNSLGEQSRDMRRSLELAMSLQEVLEKNREIYNNVIAERDEAYRRLQDADAKLQQVEHVVRRYAEVKDPVVASDGYTYERTELSRYLSDCKKSNSKAYSQQTKEELTDVMVDNVSLRRLADLLKGVHTVELPQLSSRAPLTSGGVDVNGPRSHWTEEDTSMCGMRHAEMGPGAVGHMGGAGGRGGNGMAMGHGHGGLRFDRGGVVKCCRPSNGNEGKGGRHPCLRVYGFCNFEDDCTFANYPYEACLNHIKGKCRFGSTCKELHVDPRDPVYQNARSFANQHHNQGGHSATMAHIHNTGGGSNHTNTSQAADTGAEASRQSGGKIPEIVAERESETASAKTEGKPKEIGEAPYATPADAATAKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KSF8</accession>
    <name>A0A836KSF8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_06617</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000010">
        <property type="protein sequence ID" value="KAG5485659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065243.1">
        <property type="nucleotide sequence ID" value="XM_067208532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KSF8"/>
    <dbReference type="GeneID" id="92362466"/>
    <dbReference type="KEGG" id="loi:92362466"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF349">
        <property type="entry name" value="AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="6">
        <location>
            <begin position="65"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5485659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="470" mass="51668" checksum="6535CFB8C57C1642" modified="2021-09-29" version="1">MEDERRDKTLVEGFVKMSEVEVAGDSNNGGLVFEQSGEKGQDYVEMDEDDLPTGPPAAAGELKENTNICKSAFHVFKANVGTGVFLLPTFYPDAGYVVSVILAILIGAAVVDCTRLLVDVKVTINRGDVTTYSQVCRYVCGAGLGWFLFVAMCLTQFGFCLMYSQLFADTMGELATFDGSKYVWVSLMFVLAFPMTCFSDNLSLLAIASIIATVSVFYTLICCLVESLKQLSQSGIHPGCDVAGNRIPVGWFNNLANNMMVLEGIAIILPVHAACTQKRLVPTMATVVIGGVICWYLLFGLTGYLAYGNTMTTSLVAKMEHSPWGTSVRVLFALNVVFTYPLQFMSAMQLIDQTVKRKPRSWIGLGLRLLINLFIWALAMALPTSAVNTVVALIGALPSVCMVLIIPSILTMQVQYAVDHPDENRNKLQYWKKVFLAKPCFTFKRIRCYLYLVVALLIMVIGTYSIAENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KTI9</accession>
    <name>A0A836KTI9_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_07354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000008">
        <property type="protein sequence ID" value="KAG5486426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065492.1">
        <property type="nucleotide sequence ID" value="XM_067209249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KTI9"/>
    <dbReference type="GeneID" id="92363183"/>
    <dbReference type="KEGG" id="loi:92363183"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="280"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5486426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="508" mass="53808" checksum="FF0894348E7B9E94" modified="2021-09-29" version="1">MPPGPRQLHACAGLALPSGIGQQPQPLATRTVCRLLKTRHGSCAAANGDRPAAALTAEELLHANEDYTNAREGRSGHDGGAGAAAEEEEVIVFAPPPAAPDGRSARARGRSDGEAVDTFRRHLRPYEEEDYSATAATVTAAAADAAATAVFAEGVPDSAAEFPSRRGRESAAELSSSVWDWSAERAAPRPHLSAGDDQMAQAEGESDGDTSEYRSDTRASSRLSLQVKRCWEANPAPATRAASTRGFDGRCKAVSAVKTCVAVAGVSRAPYASAEEDTRPSPLLLLPSASSSARRGDATPAMLRFVTERCGRRESDVDDDALFSCITTTRATFATIDNSAREDGRSRRSQGALVEREVRSTVSASDLQLVIPGHFSVQQGGDGADDGEMLRDRLLTTAPSSSSGRRTAALTHGDSGKFSSDACCSIAPRYRRHARYMAMRDLWSAPSPTASLSPTTSSTAFLQLFASSPLSHSAVYEADAEATSRMWSIIMAYYAAHHAPQAPRRTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KTM2</accession>
    <name>A0A836KTM2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Amastin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_05583</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000016">
        <property type="protein sequence ID" value="KAG5482330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064336.1">
        <property type="nucleotide sequence ID" value="XM_067207522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KTM2"/>
    <dbReference type="GeneID" id="92361456"/>
    <dbReference type="KEGG" id="loi:92361456"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40741:SF1">
        <property type="entry name" value="AMASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40741">
        <property type="entry name" value="AMASTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032447187" description="Amastin-like protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5482330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="201" mass="21803" checksum="C1360DDEC1B47334" modified="2021-09-29" version="1">MKCCRVFIFVLLMLCTACATCSILFPQFRKIVDRATMRTSTVYLWYRESSMPIQEAQSVSINRTYSYHLPCPRGQLFNTVSAALSVAATALISSSMLFAACWIDARYNNGLAVAGAFMAFLSFAGFGAVLSWLVYTYLTTLCPGEAVQILGAKEDGYALAEGFYLLCAATGGALLCFVISFALCCSAVCCSSEVKNNGPYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KUE5</accession>
    <name>A0A836KUE5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">adenylate cyclase</fullName>
            <ecNumber evidence="6">4.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">ATP pyrophosphate-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Adenylyl cyclase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">LSCM4_08009</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">LSCM4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Could act as a receptor for an unknown ligand.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP = 3',5'-cyclic AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15389"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="EC" id="4.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the adenylyl cyclase class-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.1" evidence="6"/>
    <dbReference type="EMBL" id="JAFHLR010000005">
        <property type="protein sequence ID" value="KAG5487564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065852.1">
        <property type="nucleotide sequence ID" value="XM_067209885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KUE5"/>
    <dbReference type="SMR" id="A0A836KUE5"/>
    <dbReference type="GeneID" id="92363819"/>
    <dbReference type="KEGG" id="loi:92363819"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000022">
        <property type="entry name" value="Receptor-type adenylate cyclase GRESAG 4, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050697">
        <property type="entry name" value="Adenylyl/Guanylyl_Cyclase_3/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43081:SF1">
        <property type="entry name" value="ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43081">
        <property type="entry name" value="ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="20" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="50"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="190"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="378"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00032597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00032637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAG5487564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="841" mass="94970" checksum="48DFFC3A58A0699A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KUW8</accession>
    <name>A0A836KUW8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Threonine synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_04862</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000014">
        <property type="protein sequence ID" value="KAG5483710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064649.1">
        <property type="nucleotide sequence ID" value="XM_067206840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KUW8"/>
    <dbReference type="SMR" id="A0A836KUW8"/>
    <dbReference type="GeneID" id="92360774"/>
    <dbReference type="KEGG" id="loi:92360774"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1380.10:FF:000005">
        <property type="entry name" value="Putative threonine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000075">
        <property type="entry name" value="Threonine synthase ThrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1380.10">
        <property type="entry name" value="Threonine synthase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029144">
        <property type="entry name" value="Thr_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037158">
        <property type="entry name" value="Thr_synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43515">
        <property type="entry name" value="THREONINE SYNTHASE-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43515:SF1">
        <property type="entry name" value="THREONINE SYNTHASE-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14821">
        <property type="entry name" value="Thr_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Threonine synthase N-terminal" evidence="6">
        <location>
            <begin position="103"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="5">
        <location>
            <begin position="239"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR604450-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5483710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="676" mass="73146" checksum="BC9891AC049FB630" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KWC6</accession>
    <name>A0A836KWC6_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_08144</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000002">
        <property type="protein sequence ID" value="KAG5488167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066215.1">
        <property type="nucleotide sequence ID" value="XM_067210017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KWC6"/>
    <dbReference type="GeneID" id="92363951"/>
    <dbReference type="KEGG" id="loi:92363951"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5488167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="761" mass="82700" checksum="DB7D71A66D8B6664" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KWD0</accession>
    <name>A0A836KWD0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable 26S proteasome regulatory subunit rpn-6.2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_08161</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. In the complex, rpn-6.2 is required for proteasome assembly.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000002">
        <property type="protein sequence ID" value="KAG5488182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066230.1">
        <property type="nucleotide sequence ID" value="XM_067210032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KWD0"/>
    <dbReference type="SMR" id="A0A836KWD0"/>
    <dbReference type="GeneID" id="92363966"/>
    <dbReference type="KEGG" id="loi:92363966"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000019">
        <property type="entry name" value="Proteasome regulatory non-ATPase subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050871">
        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040773">
        <property type="entry name" value="Rpn6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18055">
        <property type="entry name" value="RPN6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="6">
        <location>
            <begin position="225"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="481"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="484"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="513"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00056935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00069091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5488182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="534" mass="59304" checksum="E2126A72E4779D10" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KXQ8</accession>
    <name>A0A836KXQ8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_06899</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000017">
        <property type="protein sequence ID" value="KAG5481823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064183.1">
        <property type="nucleotide sequence ID" value="XM_067208809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KXQ8"/>
    <dbReference type="SMR" id="A0A836KXQ8"/>
    <dbReference type="GeneID" id="92362743"/>
    <dbReference type="KEGG" id="loi:92362743"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="237"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="75"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="152"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5481823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="319" mass="34713" checksum="DB58EFD2866DAED1" modified="2021-09-29" version="1">MDGRLVQTSCRTTEFSAVEATLREWPEVEAVGSFREKRNNMKDITTVFVTFRDEAAAKAAKAKLDAIPGIAGAATTLSASPKQDKAEPSSRQGKRAQKKGKAGGYKNLAAEFLRFESHRDQKQREVNSKKKNDVAPEEAGAQAARRGRGRHGAGCGTGGRGGRGGGLGERGENRGINNDYGRGAGVNRPAMRGRSGAHLQPPEAHLLPPETHLQPPEMYLQPQPYQPPPRLPPFEANVAFVDNVPFGTTNRYLMERFSAFGRILDVNRLELMVMICFDNPESVQQCIQHMNGTKIHDNVITVSSGTIRIPGSVAIQMGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KY53</accession>
    <name>A0A836KY53_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_07708</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <comment type="caution">
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        <source>
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        </source>
    </evidence>
    <sequence length="275" mass="30325" checksum="AB292176B1F4B2FA" modified="2021-09-29" version="1">MPSAPACQHGSYHECNCYGHSTELPNYRRDISNPRTLQGYYAPHGGCPCPAKCDGEKSGLYCSARGADASAMPKATFRAADGPHTVHTAADVDGNGRDPATSIRTAFPNSRNYGGTVAQRGPTTLSTRAQLVASRKACAEAKREERAQDRKNFLRSVLRDEMLARMDAEGKRAALEVDMGLMGTHHIDEYEASRRAGGSIHGGLGSTSRDQDIVPTLEEQYGEIMDELQYVTGQPVGSKYNIIRLHYLVEEQNRLNQLRWQQRLQKAAEEMHSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FZG4</accession>
    <name>A0A836FZG4_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_00172</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058362.1">
        <property type="nucleotide sequence ID" value="XM_067202261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836FZG4"/>
    <dbReference type="GeneID" id="92356195"/>
    <dbReference type="KEGG" id="loi:92356195"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009450">
        <property type="entry name" value="Plno_GlcNAc_GPI2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12982">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12982:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06432">
        <property type="entry name" value="GPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016104">
        <property type="entry name" value="GPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="335"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5464731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="387" mass="43023" checksum="F40D2F817B2D1751" modified="2021-09-29" version="1">MSQLFSSSEALDASQQQLETDRHAASTERQSSATESGEDDRHSCQADLYGSRPNHHRVSSEQIITNGSPLWRKVLYERQPFEDNYVDPQQFLEELSHNKDIKNYEYANVVINTLAITQEISIVVLFCHAFMGVFTNSIGKYSLVWIDVLSVLASLVCYVFYQCHQDACNANAERPVSLCTRCSPPPRPPSRWVFHAWNFGRQVVSLVSLLTLLSPILSTLTVTYSDDTIVTLSIITMSLHVLLADYSYLNAYTERFDPNLSVNMAICCVILMASRISNPLASGALICFGIMCFSLSPIVRHLIKHNSFTAHVAITFGLVGLAIGCLTQIPILAILYTVTVLMISFGIPWLFVRMHSSVKTQINGPWDEAKPTNSAAAAEWANSGFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G1K8</accession>
    <name>A0A836G1K8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Actin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059001.1">
        <property type="nucleotide sequence ID" value="XM_067203310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G1K8"/>
    <dbReference type="SMR" id="A0A836G1K8"/>
    <dbReference type="GeneID" id="92357244"/>
    <dbReference type="KEGG" id="loi:92357244"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5466111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="517" mass="53488" checksum="1410F8CEAA4D8F44" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G1N0</accession>
    <name>A0A836G1N0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_01299</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059046.1">
        <property type="nucleotide sequence ID" value="XM_067203355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G1N0"/>
    <dbReference type="SMR" id="A0A836G1N0"/>
    <dbReference type="GeneID" id="92357289"/>
    <dbReference type="KEGG" id="loi:92357289"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001025">
        <property type="entry name" value="ATPase family, AAA domain-containing 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051701">
        <property type="entry name" value="Mito_OM_Translocase_MSP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644">
        <property type="entry name" value="AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644:SF3">
        <property type="entry name" value="FI08533P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062360.1">
        <property type="nucleotide sequence ID" value="XM_067207057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G6H6"/>
    <dbReference type="GeneID" id="92360991"/>
    <dbReference type="KEGG" id="loi:92360991"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5476127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="65" mass="7226" checksum="E3F15C19331416CA" modified="2021-09-29" version="1">MNSSVSALDELEREISTYLDNMQATGDGDVGPVLFHSAMLQMEIQDLSQRVQQKSVALEERARSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G7H4</accession>
    <name>A0A836G7H4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_00980</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059696.1">
        <property type="nucleotide sequence ID" value="XM_067203046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G7H4"/>
    <dbReference type="SMR" id="A0A836G7H4"/>
    <dbReference type="GeneID" id="92356980"/>
    <dbReference type="KEGG" id="loi:92356980"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF837">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="6">
        <location>
            <begin position="117"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5467894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="391" mass="41720" checksum="B1E913A8B21D4ED0" modified="2021-09-29" version="1">MSLRPVHRSIATCVAINAMHDGRAPHHKPGVSGSSNCFPCVYLNSESFGLNSEAERASIGSSTCDSVESFHILIPRELQTSVEQFTMPEVPRHPSHPSLCTAFFRGTNEAQHQLVHEVGVASDQGIRSSMEDEHVTVVEPDVCFFGIYDGHGGRQCAEFVRSRLHKIALAHDSLKTAPRKALSDAFAQVEHEFLGRSADGISSAGCVCAAAIIQGSVLTVGNVGDCEVVLARAGQPVLLTVKHNPSCNDAEATRVKKAGGCIFNCRVGHPRLNPRMCSLAVSRAVGDAGFKLEEYTNGKPSGVIAVADTSEVSLTEEDAFLILACDGLWDTMSYAEAVELATTYTASGADANSVADQLVREALRRGTRDNVTAIFVRLSQSTPAGPDKAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GB61</accession>
    <name>A0A836GB61_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_02793</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060365.1">
        <property type="nucleotide sequence ID" value="XM_067204813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GB61"/>
    <dbReference type="GeneID" id="92358747"/>
    <dbReference type="KEGG" id="loi:92358747"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47936:SF1">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN GUN1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47936">
        <property type="entry name" value="PPR_LONG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="203"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="238"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="369"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="371"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5470099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="801" mass="90594" checksum="202A378EF98A6A8C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GBZ0</accession>
    <name>A0A836GBZ0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CLN3 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_01745</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">LSCM4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the battenin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000022">
        <property type="protein sequence ID" value="KAG5479157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063250.1">
        <property type="nucleotide sequence ID" value="XM_067203791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GBZ0"/>
    <dbReference type="GeneID" id="92357725"/>
    <dbReference type="KEGG" id="loi:92357725"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003492">
        <property type="entry name" value="Battenin_disease_Cln3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981:SF7">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02487">
        <property type="entry name" value="CLN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01315">
        <property type="entry name" value="BATTENIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="437"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="472"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="614"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5479157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="644" mass="72254" checksum="4140683815B92A84" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GEC0</accession>
    <name>A0A836GEC0_9TRYP</name>
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        <recommendedName>
            <fullName evidence="1">DUF1935 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000020">
        <property type="protein sequence ID" value="KAG5480432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="SMR" id="A0A836GEC0"/>
    <dbReference type="GeneID" id="92362057"/>
    <dbReference type="KEGG" id="loi:92362057"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
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        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036310">
        <property type="entry name" value="Smp-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47047:SF6">
        <property type="entry name" value="PROTEIN, PUTATIVE CALPAIN-LIKE CYSTEINE PEPTIDASE, CLAN CA, FAMILY C2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47047">
        <property type="entry name" value="PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09149">
        <property type="entry name" value="DUF1935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101601">
        <property type="entry name" value="Smp-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1935" evidence="1">
        <location>
            <begin position="19"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5480432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="146" mass="16577" checksum="F76B76B5681B6241" modified="2021-09-29" version="1">MGCFNSTGHVANQDPTNGFMYTKPKAKGTKEALFGGLLYRIADEETSRWAFYNNSKDYEFHLKYLFGADSRLDALGDTTLEMQDDGILAQTVVYPLETKDFVQGTIDGYESKLEALPLSEEYFAQHPEQDEAAYYRRLEAPKSSQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GER6</accession>
    <name>A0A836GER6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_03711</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061644.1">
        <property type="nucleotide sequence ID" value="XM_067205707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GER6"/>
    <dbReference type="SMR" id="A0A836GER6"/>
    <dbReference type="GeneID" id="92359641"/>
    <dbReference type="KEGG" id="loi:92359641"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08215">
        <property type="entry name" value="STKc_Nek"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001074">
        <property type="entry name" value="Putative serine/threonine-protein kinase Nek3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000971">
        <property type="entry name" value="Putative serine/threonine-protein kinase Nek3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051131">
        <property type="entry name" value="NEK_Ser/Thr_kinase_NIMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899">
        <property type="entry name" value="CAMK FAMILY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="15"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="389"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="396"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="409"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5473641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="544" mass="60570" checksum="E197D1FDABB62DFE" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GG19</accession>
    <name>A0A836GG19_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_02290</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061360.1">
        <property type="nucleotide sequence ID" value="XM_067204323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GG19"/>
    <dbReference type="SMR" id="A0A836GG19"/>
    <dbReference type="GeneID" id="92358257"/>
    <dbReference type="KEGG" id="loi:92358257"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14136">
        <property type="entry name" value="STKc_SRPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000275">
        <property type="entry name" value="SRSF protein kinase 2 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000322">
        <property type="entry name" value="Uncharacterized protein, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="159"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="311"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="568"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="674"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="571"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="587"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="602"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="674"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="689"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="725"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5472964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="744" mass="84024" checksum="294C6D76F5506600" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GGG1</accession>
    <name>A0A836GGG1_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GGG1"/>
    <dbReference type="GeneID" id="92359183"/>
    <dbReference type="KEGG" id="loi:92359183"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="823"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="928"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="949"/>
            <end position="960"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5471684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1041" mass="109416" checksum="F327013E51EE59C0" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GGJ4</accession>
    <name>A0A836GGJ4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peroxisome assembly protein 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_00326</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058511.1">
        <property type="nucleotide sequence ID" value="XM_067202410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GGJ4"/>
    <dbReference type="SMR" id="A0A836GGJ4"/>
    <dbReference type="GeneID" id="92356344"/>
    <dbReference type="KEGG" id="loi:92356344"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037485">
        <property type="entry name" value="PEX22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34126">
        <property type="entry name" value="PEROXISOME BIOGENESIS PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34126:SF1">
        <property type="entry name" value="PEROXISOME BIOGENESIS PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22978">
        <property type="entry name" value="HAD_Pex22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5464880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="209" mass="23153" checksum="F14EEB1DBAC52853" modified="2021-09-29" version="1">MARVIRRSFLEEVSERLPVSTTTLVAIVVGAVSLYIFYRRKGPVRRPSTSARRPLSSPRNAGEASDAMTRIKNKAFIGKKICIAWEVLHDDKGWKAQGKALDILRFYAFSSEVYLMCRICGADDKKKIIDLVKAVDGIERHRILFCTTEKGYEAFTRQIDPSLLVTNDAAQVVFLKRVIHTLVLVGGDGVVASNVACVPSVEAIAVDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GGQ7</accession>
    <name>A0A836GGQ7_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060936.1">
        <property type="nucleotide sequence ID" value="XM_067205384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GGQ7"/>
    <dbReference type="GeneID" id="92359318"/>
    <dbReference type="KEGG" id="loi:92359318"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5471819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="388" mass="41208" checksum="B48A9F99B8B52771" modified="2021-09-29" version="1">MGAGSSAEANGHMSNSSKCSSTLELFDMCSISLSEQEGMVPPQPSKGTGPHEMSTVAEKASPKLTSTSLPTSLTAKRGVPAIEAAVPSRNDREVPVLHALEERKGLPAKTQPRSRSRATAQRPKTGHSCRLPQLPMRTPLPECLSRADRQRTATHAESSRKDQDCSLSSYGVSMADASAAMVEKQKKTSQLQRQRLSRKETEGLLPPLPGRRADRKSAAGAGDEAPRNTSQTSPHPTLEPQSGWTGHSTALPVLAPTVTPTLQPLASTATLSSGDSHNFYLFAGNDQNASRVPLGKGLQSFIDDGGYGMYLTDMKLEGPTGGVAEATPEPEPAFTPQLSSAQGEALSSEPDSDTSSVRLLRAKRRPSLLSKRSRRGSFVSFGGEVRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GGU1</accession>
    <name>A0A836GGU1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">SNF2 DNA repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_03462</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061402.1">
        <property type="nucleotide sequence ID" value="XM_067205465.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92359399"/>
    <dbReference type="KEGG" id="loi:92359399"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:004822">
        <property type="entry name" value="SNF2 DNA repair protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044574">
        <property type="entry name" value="ARIP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45797:SF1">
        <property type="entry name" value="HELICASE ARIP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45797">
        <property type="entry name" value="RAD54-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="73"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="500"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="453"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="980"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1342"/>
            <end position="1480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="462"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="988"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1342"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1364"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1400"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1433"/>
            <end position="1445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5473399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1587" mass="175220" checksum="A5C00CA429E46867" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GH04</accession>
    <name>A0A836GH04_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_06966</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000017">
        <property type="protein sequence ID" value="KAG5481887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064247.1">
        <property type="nucleotide sequence ID" value="XM_067208873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GH04"/>
    <dbReference type="GeneID" id="92362807"/>
    <dbReference type="KEGG" id="loi:92362807"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="506"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="432"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="520"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5481887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="663" mass="69934" checksum="09CB9EDA2B7BF9FA" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GI30</accession>
    <name>A0A836GI30_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_05670</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="10">Binds 1 heme group per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome c family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000016">
        <property type="protein sequence ID" value="KAG5482412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064418.1">
        <property type="nucleotide sequence ID" value="XM_067207604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GI30"/>
    <dbReference type="SMR" id="A0A836GI30"/>
    <dbReference type="GeneID" id="92361538"/>
    <dbReference type="KEGG" id="loi:92361538"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.760.10:FF:000014">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002327">
        <property type="entry name" value="Cyt_c_1A/1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11961">
        <property type="entry name" value="CYTOCHROME C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00604">
        <property type="entry name" value="CYTCHRMECIAB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4 8 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 8 10" id="KW-0408">Iron</keyword>
    <keyword evidence="5 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome c" evidence="11">
        <location>
            <begin position="12"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5482412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="114" mass="12231" checksum="9B3ADC8F370C238D" modified="2021-09-29" version="1">MPPKARAPLPPGDVVRGEKLFKGRAAQCHTATKGGSNGVGPNLFGVVNRRSGTIDGFAYSKANAESGVIWTPEVLDVYLENPKKFMPGTKMAFAGIKKPQERADVIAYLESLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GIV6</accession>
    <name>A0A836GIV6_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_00098</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058289.1">
        <property type="nucleotide sequence ID" value="XM_067202188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GIV6"/>
    <dbReference type="SMR" id="A0A836GIV6"/>
    <dbReference type="GeneID" id="92356122"/>
    <dbReference type="KEGG" id="loi:92356122"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5464658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="194" mass="22160" checksum="88C71BF64183DEBA" modified="2021-09-29" version="1">MSSKGVDVFNVSQNRLRAATFQDEEERQNAEYAERHNLQALFSEFAAQLREKDPKTEHEAERVLLDLLSHRKAERDRAALRLHFVNSFEVNLDNGRRMLKLTSGSETSTLHLVQKTRSVAVDDTFTVSLEEAEELTEMFYELGRFVVEFAKGELNGFISIDDRDVYLLAGGKDCSDIGDELFNMAFLMKASSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GIY4</accession>
    <name>A0A836GIY4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RanBP2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_00144</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058334.1">
        <property type="nucleotide sequence ID" value="XM_067202233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GIY4"/>
    <dbReference type="SMR" id="A0A836GIY4"/>
    <dbReference type="GeneID" id="92356167"/>
    <dbReference type="KEGG" id="loi:92356167"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23111:SF100">
        <property type="entry name" value="RANBP2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23111">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00641">
        <property type="entry name" value="Zn_ribbon_RanBP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="5">
        <location>
            <begin position="71"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="5">
        <location>
            <begin position="100"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="5">
        <location>
            <begin position="277"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="5">
        <location>
            <begin position="308"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="5">
        <location>
            <begin position="391"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="5">
        <location>
            <begin position="517"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5464703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="561" mass="61972" checksum="2286C14A9385E7CB" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GM23</accession>
    <name>A0A836GM23_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LSCM4_01117</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5468030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059832.1">
        <property type="nucleotide sequence ID" value="XM_067203182.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836GM23"/>
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        <property type="entry name" value="Region D6 of dynein motor"/>
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        <property type="entry name" value="DHC"/>
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        <property type="entry name" value="Dynein_2_N"/>
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        <property type="entry name" value="Dynein_C"/>
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        <property type="entry name" value="Dynein_heavy_linker"/>
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        <property type="entry name" value="Dynein_heavy_tail"/>
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        <property type="entry name" value="Dynein_linker_3"/>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="4"/>
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    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="9 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="1937"/>
            <end position="2074"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="2216"/>
            <end position="2461"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="2565"/>
            <end position="2736"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="2933"/>
            <end position="3095"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="1646"/>
            <end position="1673"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="3191"/>
            <end position="3269"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="3395"/>
            <end position="3461"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="3719"/>
            <end position="3795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG5468030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="4645" mass="528633" checksum="ED6EEAE3CF215037" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GM68</accession>
    <name>A0A836GM68_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_01548</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059288.1">
        <property type="nucleotide sequence ID" value="XM_067203597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GM68"/>
    <dbReference type="SMR" id="A0A836GM68"/>
    <dbReference type="GeneID" id="92357531"/>
    <dbReference type="KEGG" id="loi:92357531"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.525.10:FF:000030">
        <property type="entry name" value="CRAL/TRIO_-_N-terminal_domain/CRAL /TRIO_domain_containing_protein_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052578">
        <property type="entry name" value="PI_Transfer_CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824:SF29">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <end position="306"/>
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        <source>
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    </evidence>
    <sequence length="378" mass="43934" checksum="A6BA69EAE1E8E840" modified="2021-09-29" version="1">MASKKDPSASASMPPTPSDSDAAACSSGASTIEADLDLPKDCFLFPKQNDAFQIPYFLSSTEEVAKIRPPAVVKTWEQRVAELKDVQQRKLEEFKKMVIAAPWYEEKKFDDWLCLRYLIARSFSISEAFSMLENTVKWWKETGSEAWQCDACMENPNHHMGQFIGWDKEHRPVMFMSMRWGPERKNPLRHMVCSFNHLIRLMPVGVEKWVCVTDFETYSHLHDGKPSVGVSVIRVIQDHYPERLGKMVCINPPKLFSILWKLILPVIDPVTRTKVEFLWTEAQPSVCEAFPRLFPPHLSEYLSDSYDRSKFNLAAKPLVWRPRPEGYPNNFEERKQQLKTMKEKEKSDKKNSKRAAHDAKKRVVAEQRREEQEKLQPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5478111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067207450.1"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
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        <property type="term" value="P:N-acylethanolamine metabolic process"/>
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            <end position="334"/>
        </location>
    </feature>
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            <begin position="35"/>
            <end position="308"/>
        </location>
    </feature>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5478111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="334" mass="38390" checksum="2ACCA87352B2DD4D" modified="2021-09-29" version="1">MKFVLLLGSVGAALGWSYLRHIQLPLGPSRLLWSGVVFGHRGCRGVAGTPENTLEAFRYAAARGCGGIECDARLTKDNEVVIFHDAFANGHLHDIPPTRRIDELTLLELRRCSLTADPTGQAHVPTLEEAILFCRDNNLRMLIEVKELRRAYLCTDKVLDLYQRYPDYMYDQTTLISFHSGILYHARKADKKVAVCQLYGPNVVRSWVSMHVDTLPWTLRLCPVLWDCLLPFVQERVMPWVMGCSMVGPRYDRFTEASRKRWATRNICMYLWGFGRDEQCTPGMRQPGVCISCDNHYECFQTPKPPPNYDIFGDKQRALERQQEEAYKRLRIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GNR8</accession>
    <name>A0A836GNR8_9TRYP</name>
    <protein>
        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="502"/>
            <end position="519"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GP61</accession>
    <name>A0A836GP61_9TRYP</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067207144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GP61"/>
    <dbReference type="GeneID" id="92361078"/>
    <dbReference type="KEGG" id="loi:92361078"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="534"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5476214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="557" mass="58774" checksum="6A802173B9203662" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GPB1</accession>
    <name>A0A836GPB1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Flagellar glycoprotein-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_06610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000010">
        <property type="protein sequence ID" value="KAG5485652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065236.1">
        <property type="nucleotide sequence ID" value="XM_067208525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GPB1"/>
    <dbReference type="SMR" id="A0A836GPB1"/>
    <dbReference type="GeneID" id="92362459"/>
    <dbReference type="KEGG" id="loi:92362459"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
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        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032891761" description="Flagellar glycoprotein-like protein" evidence="3">
        <location>
            <begin position="45"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="564"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="367"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5485652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="599" mass="62504" checksum="BFFE290885C228CB" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GQ18</accession>
    <name>A0A836GQ18_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_06779</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PET117 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000009">
        <property type="protein sequence ID" value="KAG5486072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065403.1">
        <property type="nucleotide sequence ID" value="XM_067208692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GQ18"/>
    <dbReference type="GeneID" id="92362626"/>
    <dbReference type="KEGG" id="loi:92362626"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031568">
        <property type="entry name" value="Pet117"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28163:SF1">
        <property type="entry name" value="PROTEIN PET117 HOMOLOG, MITOCHONDRIAL"/>
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    </dbReference>
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        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5486072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="96" mass="11046" checksum="BBFBFBAD53EF0BFD" modified="2021-09-29" version="1">MNSYVKRYIGSDPTVQQLVGFKRASDRHLVIGCTLAALGIYWAVYFSEENERNRRHASIEKDIERERWRARELGLAAPTDDGFAERYEAIGGKRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GQ30</accession>
    <name>A0A836GQ30_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_06795</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000009">
        <property type="protein sequence ID" value="KAG5486087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065418.1">
        <property type="nucleotide sequence ID" value="XM_067208707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GQ30"/>
    <dbReference type="GeneID" id="92362641"/>
    <dbReference type="KEGG" id="loi:92362641"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11685">
        <property type="entry name" value="UEV_TSG101-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051728">
        <property type="entry name" value="RING-FYVE_E3_ubiquitin-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
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        <property type="entry name" value="UEV_N"/>
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        <property type="entry name" value="Znf_RING"/>
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    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14879">
        <property type="entry name" value="CASPASE REGULATOR, RING FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14879:SF5">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05743">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51322">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UEV" evidence="3">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="2">
        <location>
            <begin position="208"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5486087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="28335" checksum="E9AB35521855E043" modified="2021-09-29" version="1">MNDDVVRFFSSTSRYRPEVLRRIVLDIDKVCTSLGFSRKITTWGSTEQPKICLYGGLPASFPMMTRIETGVECGSASQPVVQPFLIPIQIWVSRQFPAEPPFIYLVCNRISEHSRIPESVNVSVVKIVNNHPNVDFTGLCFCKELAEWNPSSSSLCFAVERLRRALEKSGRCPIYIDQRICGNSVAADGNDSPSDSKGVTDDTLPNTCLVCYRKKDTVLVPCGHFCMCMSCSANLTECPLCRSKIMVRQRVFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GSF6</accession>
    <name>A0A836GSF6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">L-dopachrome isomerase</fullName>
            <ecNumber evidence="9">5.3.2.1</ecNumber>
            <ecNumber evidence="8">5.3.3.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">L-dopachrome tautomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Phenylpyruvate tautomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LSCM4_02494</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-phenylpyruvate = enol-phenylpyruvate</text>
            <dbReference type="Rhea" id="RHEA:17097"/>
            <dbReference type="ChEBI" id="CHEBI:16815"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="EC" id="5.3.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-dopachrome = 5,6-dihydroxyindole-2-carboxylate</text>
            <dbReference type="Rhea" id="RHEA:13041"/>
            <dbReference type="ChEBI" id="CHEBI:16875"/>
            <dbReference type="ChEBI" id="CHEBI:57509"/>
            <dbReference type="EC" id="5.3.3.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MIF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.2.1" evidence="9"/>
    <dbReference type="EC" id="5.3.3.12" evidence="8"/>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060075.1">
        <property type="nucleotide sequence ID" value="XM_067204523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GSF6"/>
    <dbReference type="SMR" id="A0A836GSF6"/>
    <dbReference type="GeneID" id="92358457"/>
    <dbReference type="KEGG" id="loi:92358457"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004167">
        <property type="term" value="F:dopachrome isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050178">
        <property type="term" value="F:phenylpyruvate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="entry name" value="Macrophage Migration Inhibitory Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001398">
        <property type="entry name" value="Macrophage_inhib_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11954">
        <property type="entry name" value="D-DOPACHROME DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11954:SF6">
        <property type="entry name" value="MACROPHAGE MIGRATION INHIBITORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01187">
        <property type="entry name" value="MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="Tautomerase/MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0202">Cytokine</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00036823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG5469098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="113" mass="12712" checksum="0E3234F92CA4D422" modified="2021-09-29" version="1">MPVIQTFVSTLLEHQKREHLAQVYRSITRDVLGKPENLTMMTFHDNVPMHFFGSTDPVAYVKVEALGGYGPSEPKMMTSIITAAVTRECGIPADRIFVLYYSPLQCGWNGTNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GU70</accession>
    <name>A0A836GU70_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutathione S-transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_00568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058747.1">
        <property type="nucleotide sequence ID" value="XM_067202646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GU70"/>
    <dbReference type="GeneID" id="92356580"/>
    <dbReference type="KEGG" id="loi:92356580"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00299">
        <property type="entry name" value="GST_C_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5465116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="644" mass="70231" checksum="1F193E00B690F544" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GU84</accession>
    <name>A0A836GU84_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_01758</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000022">
        <property type="protein sequence ID" value="KAG5479169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063262.1">
        <property type="nucleotide sequence ID" value="XM_067203803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GU84"/>
    <dbReference type="SMR" id="A0A836GU84"/>
    <dbReference type="GeneID" id="92357737"/>
    <dbReference type="KEGG" id="loi:92357737"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="3"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5479169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="82" mass="8751" checksum="021EE5B84423F980" modified="2021-09-29" version="1">MVTSIRIQSLPATYSAEKLLRLCACFGEVSAFTPVDENGAYGSAAATADVAFEEKNDALAAAANMEGMEFDGVFLRVLVRQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GVW6</accession>
    <name>A0A836GVW6_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_02185</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061256.1">
        <property type="nucleotide sequence ID" value="XM_067204219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GVW6"/>
    <dbReference type="GeneID" id="92358153"/>
    <dbReference type="KEGG" id="loi:92358153"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032485941" evidence="3">
        <location>
            <begin position="41"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5472860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="372" mass="40167" checksum="C0457ED6F6F493B4" modified="2021-09-29" version="1">MDMGTSTLRSTSCPRALASLLATGVLLLALLMVVSAPANADLVEVPLCAEKHGFAGEFNDHFSIPVEKAPEVGEAIILIARAYPPALGFLLGQWLYLNATYRVSEGVQVSKTSNSYGILELSSVAANTNIDVRVVRVRVDGPVPFRFFSLFANSPVCHVAVAPDNSFIAPVPPKLAAEPQPPLTVYFKTVLPPTVNALVVRITSDGRTRQQFRSGNTTYTSGSVLQVDSGGTVLLEYTPLPTNGTVPYCFTEVSVSYGDWEDSDAARQSSSPTSDSNGSVPLSTLPPTPQPKSALRRLVWICLYLFLFYQATVSVYNYRVLGKRDIMDIVPCAEFVAAGARMVQLATLRGIGVAQRHKEGYDSLQNIDDPYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GVZ6</accession>
    <name>A0A836GVZ6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Spermidine synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_01213</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058966.1">
        <property type="nucleotide sequence ID" value="XM_067203275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GVZ6"/>
    <dbReference type="SMR" id="A0A836GVZ6"/>
    <dbReference type="GeneID" id="92357209"/>
    <dbReference type="KEGG" id="loi:92357209"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5466076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="497" mass="54304" checksum="B26336CF28EABC78" modified="2021-09-29" version="1">MPAYFFRITSLQVCTLPFLGFGTVLLCSALWDITCSRRKAVPVFNTAIVVKTEESARYPCESIKGFDVVVRSFYVPVAVDTDGRARVPALNLRTLLHRFAGRFFDETFHVSSANATDTMTPAQSVRLVVRDAKDSAGGAGSGLITASQWPPGTSKYAALVLEPSSRSSGDSSAASPAPPRPLLRQLVDGATLQSLSRCNPRSTLLDMACEGDPAYLGAPYLRVLLSGFLLLPTTLSQLNVAVLGVGGGSLPMFLQQYFGSRMHRCDLVDVEPMCIKAAVEQLGMKELLSTVALQREGGGVRYYVEDAVQYLSRRVGDADCRSGGLLRGGLGGSAGIGEKRDAFPHHGTPVFCDVFQPTVAVSQATSAKRQRHLDLLFVDLFVGSELDRAVTTHDFLHLCRRSLSPHGVAAFNLPAADRLFVQRCNEVFGARNVYRIPVPASSNEVVLARGGAESRNTAADTPHLSHRQLYRRAQELRAQYRLPYDLANHYPVWWRLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GW70</accession>
    <name>A0A836GW70_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_00753</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="2"/>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058929.1">
        <property type="nucleotide sequence ID" value="XM_067202828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GW70"/>
    <dbReference type="SMR" id="A0A836GW70"/>
    <dbReference type="GeneID" id="92356762"/>
    <dbReference type="KEGG" id="loi:92356762"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000159">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF208">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="6">
        <location>
            <begin position="1"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5465298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="279" mass="31374" checksum="D83943A356C8112D" modified="2021-09-29" version="1">MKEGSVRVVSPRHIFCGVAERAEISFFIQGDTIYLCDSCLSVFADAGHLQQHLKSCSYAFWIPGDEVYRDEARRFCVFLLDGRKSQCVALARRICLLSKLFLVDKVTLDDVHFFSFNALFEVDDEGFHFVGYFSKEWASCSSCINTLSCVMVLPPYRSKGYGSILVRLSYEIARMEGMVGTPERPLSKGGIALFRKVWREEVLFAVFTLEERGTPVTVSELSKVSSLIIEDVLVALQDLHILFSVGKQGPLLVVSASEKARLLQRRLAAEKLYWTSAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GXD1</accession>
    <name>A0A836GXD1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LSCM4_03710</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061643.1">
        <property type="nucleotide sequence ID" value="XM_067205706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GXD1"/>
    <dbReference type="SMR" id="A0A836GXD1"/>
    <dbReference type="GeneID" id="92359640"/>
    <dbReference type="KEGG" id="loi:92359640"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070182">
        <property type="term" value="F:DNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045910">
        <property type="term" value="P:negative regulation of DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904430">
        <property type="term" value="P:negative regulation of t-circle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010569">
        <property type="term" value="P:regulation of double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090657">
        <property type="term" value="P:telomeric loop disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17970">
        <property type="entry name" value="DEAHc_FancJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001352">
        <property type="entry name" value="DNA repair helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002687">
        <property type="entry name" value="Helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF34">
        <property type="entry name" value="REGULATOR OF TELOMERE ELONGATION HELICASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="8"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG5473640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="954" mass="104451" checksum="04A6B26B6B4B50F1" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GXY4</accession>
    <name>A0A836GXY4_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_01403</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059148.1">
        <property type="nucleotide sequence ID" value="XM_067203457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GXY4"/>
    <dbReference type="SMR" id="A0A836GXY4"/>
    <dbReference type="GeneID" id="92357391"/>
    <dbReference type="KEGG" id="loi:92357391"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23655">
        <property type="entry name" value="mS61-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5466258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="291" mass="33176" checksum="6355C5D39383683A" modified="2021-09-29" version="1">MLRGCHVFRFRMKLGNMYVDYKIMSRNHRRSIRVEDALVDPLLPTTVVPLHWLEQLRCPSTRLMTGYHTEEAVYAKPSYGDRIERCGATLSSYTAGARTANAGSHPNAIRAGPVVLYITGQSIPVVLNPLFVQPEEWGLAQSSGELDLRIGMDAIEQCSLYAELRPGGLLYSKLPHASLTEAMEPVQDTLKRYGMKCGLAESPLVPRPWTRMRYMFIDELQRGPKMTEFVGYNPRSGTQWRFSQHTKYFRTGIWRETIRRNDMNDGLHAHSSWQKSPQQAVPEVSFLAPYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H048</accession>
    <name>A0A836H048_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Right handed beta helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_05572</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000016">
        <property type="protein sequence ID" value="KAG5482319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064325.1">
        <property type="nucleotide sequence ID" value="XM_067207511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H048"/>
    <dbReference type="GeneID" id="92361445"/>
    <dbReference type="KEGG" id="loi:92361445"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032802994" description="Right handed beta helix domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="103"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5482319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="495" mass="51160" checksum="F20624CE83AEA9FA" modified="2021-09-29" version="1">MRSIAFSLMLSPLSWRGGAANALALPGVGAVSTCVWRSDLAGVRRCGSLHPRISFSSRMSCHLTPARKLFGSWAAATGVESTTDGKGPTRATCEDTAALEADASLTTVQLSALRRELQQLRQQVSDLKEALEDSQEAVKQLLIFSASQAQQSACRAAASAQESSPTATPAAASAPSLNYRQHLQGACYVVRTSEELTDALRGHGSEHASRTVLLDGKLFVLNPYAPVVVDRARVSILGNNATIIGQIAVKGRGALLSVSDAFLLELGGMQLRSATVGGGDGVLAAEAAAPLATNLTEGKEKNAAAILMPVVSATVGASLHLNRCTLSSGRDGVYLGMGSHCTLNHVRIVNCVRGLYEGVGCRALILSACTFQSNRYHIVLLGPNKSERAARMFHGASGADASAAAAAAAAASSSSSGIDAVGAASSVAFTSAASVADVLARGITNDGPIAIQQTKAQVVLQHCPITDTYEDCWCDGVRLELSAQDATAGLSDPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H246</accession>
    <name>A0A836H246_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_02363</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5468970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059947.1">
        <property type="nucleotide sequence ID" value="XM_067204395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H246"/>
    <dbReference type="SMR" id="A0A836H246"/>
    <dbReference type="GeneID" id="92358329"/>
    <dbReference type="KEGG" id="loi:92358329"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
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                <person name="Bates M.D."/>
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                <person name="Bates M.D."/>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H701</accession>
    <name>A0A836H701_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Leucine-rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_05153</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062426.1">
        <property type="nucleotide sequence ID" value="XM_067207123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H701"/>
    <dbReference type="SMR" id="A0A836H701"/>
    <dbReference type="GeneID" id="92361057"/>
    <dbReference type="KEGG" id="loi:92361057"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050637">
        <property type="entry name" value="NLRP_innate_immun_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45690">
        <property type="entry name" value="NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45690:SF19">
        <property type="entry name" value="NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5476193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="603" mass="65946" checksum="946F30EBE0788AC0" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H706</accession>
    <name>A0A836H706_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_03113</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060682.1">
        <property type="nucleotide sequence ID" value="XM_067205130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H706"/>
    <dbReference type="SMR" id="A0A836H706"/>
    <dbReference type="GeneID" id="92359064"/>
    <dbReference type="KEGG" id="loi:92359064"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1030:FF:000006">
        <property type="entry name" value="Hypothetical_protein_-_conserved"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1030">
        <property type="entry name" value="Clp1, DNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.330">
        <property type="entry name" value="Pre-mRNA cleavage complex subunit Clp1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038238">
        <property type="entry name" value="Clp1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032324">
        <property type="entry name" value="Clp1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038239">
        <property type="entry name" value="Clp1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF7">
        <property type="entry name" value="POLYRIBONUCLEOTIDE 5'-HYDROXYL-KINASE CLP1 P-LOOP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16573">
        <property type="entry name" value="CLP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clp1 N-terminal" evidence="3">
        <location>
            <begin position="40"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Clp1 P-loop" evidence="4">
        <location>
            <begin position="136"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5471565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="522" mass="57465" checksum="579F610F63D79F0D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H7G7</accession>
    <name>A0A836H7G7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fungal lipase-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060922.1">
        <property type="nucleotide sequence ID" value="XM_067205370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H7G7"/>
    <dbReference type="SMR" id="A0A836H7G7"/>
    <dbReference type="GeneID" id="92359304"/>
    <dbReference type="KEGG" id="loi:92359304"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051218">
        <property type="entry name" value="Sec_MonoDiacylglyc_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856:SF25">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="1">
        <location>
            <begin position="113"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5471805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="364" mass="40885" checksum="CEC64F2D7547CC97" modified="2021-09-29" version="1">MRQLYSWAPACIATFFLGLIVLPAVSTVATPLARNRESVSSNMSLAAYDSKLAWKALHFSKSAYCPLENVKQWNCGDACSSASADFDFFGIYDDYSVGTFGFSGIDHAAKHIVVVFRGTSNAVNWLYNLDFWLTQYPNPSCQSNCKVHRGFYNSFSSLRSKLIQDLVAMHKLNPSYTFFITGHSLGGAMALLAALELAAGNSWDQAVADSDAQHHGAVPQLSRQLPVELYTFGEPRVGNQDFSRWAASVFAKHRRFRITHARDPVPRLPPRMFSYLHVPQEVWYPWSGGDAVMCQERNNEEDPSCSDSVYGTRVADHLLYLGVCTQCECTDAVMEEINRYELPPELYAILALDHAMKDLKYERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H7X9</accession>
    <name>A0A836H7X9_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_01824</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000022">
        <property type="protein sequence ID" value="KAG5479235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063328.1">
        <property type="nucleotide sequence ID" value="XM_067203869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H7X9"/>
    <dbReference type="SMR" id="A0A836H7X9"/>
    <dbReference type="GeneID" id="92357803"/>
    <dbReference type="KEGG" id="loi:92357803"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1310.10">
        <property type="entry name" value="Nucleoid-associated protein YbaB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036894">
        <property type="entry name" value="YbaB-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82607">
        <property type="entry name" value="YbaB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5479235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="302" mass="35470" checksum="840DAB55522C78D7" modified="2021-09-29" version="1">MEVYRRIAERVRGALWAHHRRLMPERQFHRILAYVYNNKYEYQIRFDRMSVVGRAWAGRVEVMTTPSGFLKRVRVNPAVEDLSPAQQHKLVLAAYADACQQGRALMEQAELKIYKQFLKDLKPIILGIRDNPEFYTVPEDSIETLGGVLRRDDASLDSGASENAARAVHRTIPMAKAHQPVDEVRRRHAWEDQWLASKQGQRWAHTLRGKEYFTRHGPQYRPRGAPGAKMRTLPFELLAPYTPMDEGRLLRRNWMAYMDNKHVAELLWTRAKVADREKQLRQLQERGQAWHRPINEDAVQRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H9C0</accession>
    <name>A0A836H9C0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pseudouridine synthase RsuA/RluA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Euglenozoa</taxon>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_067204109.1"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF77">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE PROTEIN, PUTATIVE-RELATED"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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            <begin position="25"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5472750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="477" mass="52430" checksum="C6A648F5E1526FE0" modified="2021-09-29" version="1">MHDKKDATSSATCDTLDVIYENEEMLVVSKPPDIPMDGDEAIYGRTVESLVYAHMKASGIFDETHEKLQQEQKRKKQLKFVHQLDFSTSGVLCLAFTRDMAARLAHCFEMRTARKYYVALLHGHVPSDTVPPEDGASHDQLRPPSAFDAEVRQSPFAMWANACSSAWEDVGCVQAVCFSSSYSNASASSAAEEVWEGFRHLLQQPYEAVLEAKALVNAKGAKGGEFVPVVHRFRSSCSAAPSAGTSALENSSSVPAGAVEDIIYRTLSEKTASHSLLVVELPVGYDATDPEHFRMAVTSAQSRDAKTCLLVLKRTYLAETPPAGSGTPPRSIAAHDFPSATRYPVTLVLLAPHTGRRHQLRVHCRAIGFPIVGDTLYCSNLAWCPDSLLGTPALTWGAAEARRMYLHAWRLLLPGTVTRHLDEAERVALKKKRRRETLGLSDSSSASVSASRCEWTEFVASVDLSKWYLQDAEDREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836H9G7_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_07773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
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            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000006">
        <property type="protein sequence ID" value="KAG5487284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065781.1">
        <property type="nucleotide sequence ID" value="XM_067209651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H9G7"/>
    <dbReference type="GeneID" id="92363585"/>
    <dbReference type="KEGG" id="loi:92363585"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5487284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="227" mass="23232" checksum="F3F6EF038CF81EE6" modified="2021-09-29" version="1">MANTSAASGVGLPQPVERAPVTTAEAVAARSTLAVAASPTAVIEAPGGGVVELPRGPPYEGVFLQPSTFRLNTTGSDILWVLHESNGIVAEYLDNCTSALPPVRSPESAGAKSMTTTIPSATSGNECKGSEGAASQTHRGSSGTATTEQLTAFAVVAAEIARCLNGAGSTTASMVSFDYVIKPARRRTISEAETAALRADPLTSQLVATRVNRMEEVVPGTSPYAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HA51</accession>
    <name>A0A836HA51_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_08089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000005">
        <property type="protein sequence ID" value="KAG5487644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065932.1">
        <property type="nucleotide sequence ID" value="XM_067209965.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92363899"/>
    <dbReference type="KEGG" id="loi:92363899"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
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        </location>
    </feature>
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    </feature>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="1323"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1386"/>
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        </location>
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        </location>
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            <begin position="1175"/>
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        </location>
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    <feature type="compositionally biased region" description="Gly residues" evidence="1">
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            <begin position="1218"/>
            <end position="1231"/>
        </location>
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        <location>
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            <end position="1340"/>
        </location>
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        <location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1425"/>
            <end position="1439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5487644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1478" mass="152642" checksum="DEE1B4E810E7C31C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HA62</accession>
    <name>A0A836HA62_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_06171</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
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    <reference evidence="9 10" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000020">
        <property type="protein sequence ID" value="KAG5480405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="entry name" value="cNMP-bd_dom"/>
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        <property type="entry name" value="cNMP-bd_dom_sf"/>
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        <property type="entry name" value="RmlC-like_jellyroll"/>
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        <property type="entry name" value="CRP FAMILY TRANSCRIPTIONAL REGULATORY PROTEIN"/>
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        <property type="entry name" value="REGULATORY PROTEIN YEIL"/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1890" mass="202557" checksum="03B1A4D288A065CA" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HCM9</accession>
    <name>A0A836HCM9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_04859</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000014">
        <property type="protein sequence ID" value="KAG5483707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064646.1">
        <property type="nucleotide sequence ID" value="XM_067206837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HCM9"/>
    <dbReference type="GeneID" id="92360771"/>
    <dbReference type="KEGG" id="loi:92360771"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF458">
        <property type="entry name" value="SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="612"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="673"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="707"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="735"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="784"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="816"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="860"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="901"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="924"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="968"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="10">
        <location>
            <begin position="597"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="89"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="242"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="313"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="325"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5483707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1005" mass="106348" checksum="53B31B462C90B620" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HCQ2</accession>
    <name>A0A836HCQ2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zinc finger LSD1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_04890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000014">
        <property type="protein sequence ID" value="KAG5483737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064676.1">
        <property type="nucleotide sequence ID" value="XM_067206867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HCQ2"/>
    <dbReference type="GeneID" id="92360801"/>
    <dbReference type="KEGG" id="loi:92360801"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005735">
        <property type="entry name" value="Znf_LSD1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01053">
        <property type="entry name" value="LSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06943">
        <property type="entry name" value="zf-LSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zinc finger LSD1-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5483737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="222" mass="23602" checksum="7359056D3A67B1D0" modified="2021-09-29" version="1">MLFGQLVCYGCHRIITHPLGAVTCRCRLCNTINAAQNLLINCDTCGQVLHAPINTLTLLCPCCGTITDIPEALLPPLPSCISLGGGPEEAETVIYVSHPTLPLRSRFGGEASVSTVCLTGSRRLSVPPRGNEQPRSPLSPRRRLSSKAKDTSVAQGCGEENVVDCDATDACEEDRKRRESADPSATEEETGFAATVSETSGTVRLVAPSRLAPTVMIATRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HDX2</accession>
    <name>A0A836HDX2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Carbamoyl phosphate synthase arginine-specific large chain</fullName>
            <ecNumber evidence="12">6.3.4.16</ecNumber>
            <ecNumber evidence="3">6.3.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">LSCM4_05594</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>hydrogencarbonate + NH4(+) + 2 ATP = carbamoyl phosphate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18029"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CarB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.16" evidence="12"/>
    <dbReference type="EC" id="6.3.5.5" evidence="3"/>
    <dbReference type="EMBL" id="JAFHLR010000016">
        <property type="protein sequence ID" value="KAG5482340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064346.1">
        <property type="nucleotide sequence ID" value="XM_067207532.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836HDX2"/>
    <dbReference type="GeneID" id="92361466"/>
    <dbReference type="KEGG" id="loi:92361466"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005951">
        <property type="term" value="C:carbamoyl-phosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004055">
        <property type="term" value="F:argininosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004087">
        <property type="term" value="F:carbamoyl-phosphate synthase (ammonia) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01423">
        <property type="entry name" value="MGS_CPS_I_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000019">
        <property type="entry name" value="Carbamoyl phosphate synthetase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000026">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000002">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1380:FF:000024">
        <property type="entry name" value="Carbamoyl-phosphate synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000361">
        <property type="entry name" value="Putative carbamoyl-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000092">
        <property type="entry name" value="Putative carbamoyl-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.20:FF:000006">
        <property type="entry name" value="Putative carbamoyl-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1260.10">
        <property type="entry name" value="Argininosuccinate synthetase, chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="entry name" value="Carbamoyl-phosphate synthase small subunit, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="entry name" value="Carbamoyl-phosphate synthetase, large subunit oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048268">
        <property type="entry name" value="Arginosuc_syn_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024074">
        <property type="entry name" value="AS_cat/multimer_dom_body"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CPSase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CPSase_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058047">
        <property type="entry name" value="CPSase_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003671">
        <property type="entry name" value="PRK05294.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009455">
        <property type="entry name" value="PRK12815.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009475">
        <property type="entry name" value="PRK12838.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF53">
        <property type="entry name" value="CARBAMOYL-PHOSPHATE SYNTHASE [AMMONIA], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405">
        <property type="entry name" value="CARBAMOYLTRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20979">
        <property type="entry name" value="Arginosuc_syn_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25596">
        <property type="entry name" value="CPSase_L_D1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00099">
        <property type="entry name" value="CPSGATASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69864">
        <property type="entry name" value="Argininosuccinate synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="Carbamoyl phosphate synthetase, large subunit connection domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="Carbamoyl phosphate synthetase, small subunit N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="10 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-grasp" evidence="17">
        <location>
            <begin position="498"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="17">
        <location>
            <begin position="1041"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="18">
        <location>
            <begin position="1300"/>
            <end position="1488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00074189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAG5482340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1842" mass="205915" checksum="2F39947FE74EF931" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HDY3</accession>
    <name>A0A836HDY3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Transaldolase</fullName>
            <ecNumber evidence="3 8">2.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_05611</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17053"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transaldolase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.2" evidence="3 8"/>
    <dbReference type="EMBL" id="JAFHLR010000016">
        <property type="protein sequence ID" value="KAG5482355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064361.1">
        <property type="nucleotide sequence ID" value="XM_067207547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HDY3"/>
    <dbReference type="SMR" id="A0A836HDY3"/>
    <dbReference type="GeneID" id="92361481"/>
    <dbReference type="KEGG" id="loi:92361481"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00957">
        <property type="entry name" value="Transaldolase_TalAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000088">
        <property type="entry name" value="Transaldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00492">
        <property type="entry name" value="Transaldolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004730">
        <property type="entry name" value="Transaldolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009001">
        <property type="entry name" value="PRK12346.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00874">
        <property type="entry name" value="talAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683:SF18">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00958">
        <property type="entry name" value="TRANSALDOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0704">Schiff base</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5482355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="331" mass="36596" checksum="C9D59827AD9CD3EC" modified="2021-09-29" version="1">MPSQLEQLRTMTTVVADTADFSLLKKFQPEDATTNPSLVLAGSQMPEYAHLVTDAIKYASANICKHMNHYTSDDRDEKVAALALDKLTVSFGLEILKVVPGRVSTEVDAKLSFDMEKMVQKARLIVEMYEEAGVTRDRIYIKLASTWEGIQAARELEKEGICCNLTLLFSFAQAVACAQANVSLISPFVGRILDWHRKTTPSMADSLIGAADPGVISVTKIYNYYKQHGYKTVVMGASFRNTDEILELAGCDKLTISPSLLEKLAASDGQVTRKLDPTNVTETMAKLPELSQADFRFLHNEDPMAVEKLAEGIRNFCKDTAKLMCAIRGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HFS0</accession>
    <name>A0A836HFS0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nodulin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_06008</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000011">
        <property type="protein sequence ID" value="KAG5485372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065109.1">
        <property type="nucleotide sequence ID" value="XM_067207935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HFS0"/>
    <dbReference type="GeneID" id="92361869"/>
    <dbReference type="KEGG" id="loi:92361869"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576:SF157">
        <property type="entry name" value="NODULIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576">
        <property type="entry name" value="UNCHARACTERIZED NODULIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="398"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="494"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="535"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5485372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="623" mass="68550" checksum="3E295D8AC25D74B8" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HGK3</accession>
    <name>A0A836HGK3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein bL21m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_04903</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000014">
        <property type="protein sequence ID" value="KAG5483750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064689.1">
        <property type="nucleotide sequence ID" value="XM_067206880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HGK3"/>
    <dbReference type="SMR" id="A0A836HGK3"/>
    <dbReference type="GeneID" id="92360814"/>
    <dbReference type="KEGG" id="loi:92360814"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028909">
        <property type="entry name" value="bL21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036164">
        <property type="entry name" value="bL21-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001787">
        <property type="entry name" value="Ribosomal_bL21"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00061">
        <property type="entry name" value="L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL21M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00829">
        <property type="entry name" value="Ribosomal_L21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141091">
        <property type="entry name" value="L21p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5483750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="186" mass="20909" checksum="51B7D3AE7184C4BF" modified="2021-09-29" version="1">MLRCANPTIAKALQPLIEGPKFAVVYCGNHQYKVSPGDVIAVQRLRAPIGSQIALKKVLMVGGPRFTAIGRPLLEHVRVTADVEEQKRMRNVVSLFSTPGRRRLRWVDAQHAATILRIREVVYEPTVLGELDKYSGVLLKDFHAERHPNPVFTANDGYDLCYPKDWDRVEEASAFSEMAEAPRTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HKE4</accession>
    <name>A0A836HKE4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_07526</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000004">
        <property type="protein sequence ID" value="KAG5487847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066044.1">
        <property type="nucleotide sequence ID" value="XM_067209412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HKE4"/>
    <dbReference type="SMR" id="A0A836HKE4"/>
    <dbReference type="GeneID" id="92363346"/>
    <dbReference type="KEGG" id="loi:92363346"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23813">
        <property type="entry name" value="UBCc_UBE2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000091">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5487847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="148" mass="16949" checksum="6757FDE67AA0A54F" modified="2021-09-29" version="1">MLTTRIIKETEKLQKECPPGITATPTKENPRYFMVTIQGPPQSCYEGGLFRLELFLPEEYPMKPPKVRFLTRIYHPNVDKVGRICLDIIKDKWSPALLINKVLLSIQILMSSPNPDDPLANDVAEHWKDDEAGALQTAREWTRKYAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HMF0</accession>
    <name>A0A836HMF0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aquaporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_01885</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">LSCM4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000022">
        <property type="protein sequence ID" value="KAG5479293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063386.1">
        <property type="nucleotide sequence ID" value="XM_067203927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HMF0"/>
    <dbReference type="SMR" id="A0A836HMF0"/>
    <dbReference type="GeneID" id="92357861"/>
    <dbReference type="KEGG" id="loi:92357861"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45724:SF13">
        <property type="entry name" value="AQUAPORIN NIP1-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45724">
        <property type="entry name" value="AQUAPORIN NIP2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5479293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="294" mass="30969" checksum="E6B6086FCB9C0221" modified="2021-09-29" version="1">MLTAESNSEVEPPMSPGSSKNATTARVAGRPGVAGATSAAAASAPVLNTNTAIKKLSCLQNLRFDALTSAAVVEFIGTFLFVLTVPLSTIQNAEMAPISIGFLLMSLVFSFGYLSGGHMNPMVTISVWLATSSGEGYATFSKRRLIMYLVAQMAGGVMAAFYCMTINGRDFPVPSMGLSFNRMLRGFLAESVFTFVLCSVVLHVAISQQRNNNFYGFAIGFSVLCGGLTCGPISGGVFNPAVATPLIVVRCLFSFSESACTPMASLWVYWASEAVGAVCASIMYVALQNVGDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HNA1</accession>
    <name>A0A836HNA1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">U-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_07749</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000006">
        <property type="protein sequence ID" value="KAG5487260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065757.1">
        <property type="nucleotide sequence ID" value="XM_067209627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HNA1"/>
    <dbReference type="SMR" id="A0A836HNA1"/>
    <dbReference type="GeneID" id="92363561"/>
    <dbReference type="KEGG" id="loi:92363561"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16655">
        <property type="entry name" value="RING-Ubox_WDSUB1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052085">
        <property type="entry name" value="WD-SAM-U-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46573">
        <property type="entry name" value="WD REPEAT, SAM AND U-BOX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46573:SF1">
        <property type="entry name" value="WD REPEAT, SAM AND U-BOX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="U-box" evidence="3">
        <location>
            <begin position="570"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="336"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5487260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="649" mass="69350" checksum="89819A42843754F5" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HNZ5</accession>
    <name>A0A836HNZ5_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_08110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000005">
        <property type="protein sequence ID" value="KAG5487665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065953.1">
        <property type="nucleotide sequence ID" value="XM_067209986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HNZ5"/>
    <dbReference type="SMR" id="A0A836HNZ5"/>
    <dbReference type="GeneID" id="92363920"/>
    <dbReference type="KEGG" id="loi:92363920"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="18"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5487665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="433" mass="49515" checksum="53D5F19C128ED993" modified="2021-09-29" version="1">MFRTSSLAVPRLATKTGAILSRQGKAEKASAPPNPEASTEKGTDSVVAERPAASLQSFIIDRTKEAGTHILPQKVLKELLNSVSAGQQNFLFGSERDATDPAGGVLRATGSFFESINTAYEGRMLQEQQVEVENFVAKRRVHYMQRLSEETEEFRREQKEIHDEIQRLEAEKYKNDLNNDVTHFTKAREAEYEGRLHADVEKYYNALLAYRARLKNDQPGANGEVMGKQLNMNVIEVMQEMEIDDTLRDFGDAAGIGNDLSDQDIRSYVVERTCFYEKVVQDEVHYFTKRRKSFYEDLLEARAARHAAKIRADTEKFHNQRRSYYDERLTADGSWMAKCFQEHYNRCFLQSYARRAWIEHRRYQATLEGIKLCGENGEKVPAISNLADISISTLNAEIPLSTILDMYETENMAEVTRDVFLKAARRVAADYTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HPN5</accession>
    <name>A0A836HPN5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1935 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000020">
        <property type="protein sequence ID" value="KAG5480433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063764.1">
        <property type="nucleotide sequence ID" value="XM_067208124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HPN5"/>
    <dbReference type="SMR" id="A0A836HPN5"/>
    <dbReference type="GeneID" id="92362058"/>
    <dbReference type="KEGG" id="loi:92362058"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015232">
        <property type="entry name" value="DUF1935"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036310">
        <property type="entry name" value="Smp-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47047:SF7">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47047">
        <property type="entry name" value="PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09149">
        <property type="entry name" value="DUF1935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101601">
        <property type="entry name" value="Smp-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1935" evidence="1">
        <location>
            <begin position="14"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5480433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="133" mass="15099" checksum="8FF5A9AADF25F6C6" modified="2021-09-29" version="1">MGSGKSKEAAPLAYKNGKPTVKGTRTYPMFSNTLYRIADTDANRWAFYNDSKDLIIHVAVLFDYDSQIVPLGDTTAFRIDDPDEGNEDDFGKFLCEVDVRPLETQMFVEGSVTGWRVDTLEARTAEDEREYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HRU4</accession>
    <name>A0A836HRU4_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_07351</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000008">
        <property type="protein sequence ID" value="KAG5486423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065489.1">
        <property type="nucleotide sequence ID" value="XM_067209246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HRU4"/>
    <dbReference type="SMR" id="A0A836HRU4"/>
    <dbReference type="GeneID" id="92363180"/>
    <dbReference type="KEGG" id="loi:92363180"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd04645">
        <property type="entry name" value="LbH_gamma_CA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047324">
        <property type="entry name" value="LbH_gamma_CA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050484">
        <property type="entry name" value="Transf_Hexapept/Carb_Anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13061:SF40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13061">
        <property type="entry name" value="DYNACTIN SUBUNIT P25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5486423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="294" mass="32810" checksum="2984F21230813D98" modified="2021-09-29" version="1">MSRNATTVPGFFPYLGYMLKDVGSRLSMISHYMQTKRHPYPMMRHQNIRAYRGMLPWTQDAGFIAPSAFVVGNVVLGHDTVIFYHSVLRNYHTKTATILGDHTAVMDRATLMGQIRVGNNTYIGAGATLDCCEVNDNVYIGPGASIALGAVIENNAIVAAGSAVPKDSRVYAAELWAGNPAQKVADVTPAQSSEVEHLVHDQVQVGKSHYRAILDHVEHTKELDVNWLKEAVAMMEAQQQQMSIKLPMEIPLEARRFLQPRVHMRRPEMHMRMSYPVNRTAPWMPKSGDQTANV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HU94</accession>
    <name>A0A836HU94_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Katanin p60 ATPase-containing subunit A-like 2</fullName>
            <shortName evidence="8">Katanin p60 subunit A-like 2</shortName>
            <ecNumber evidence="8">5.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">p60 katanin-like 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">KATNAL2</name>
        <name evidence="11" type="ORF">LSCM4_07928</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">LSCM4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers.</text>
            <dbReference type="EC" id="5.6.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
            <location evidence="1 8">Cytoskeleton</location>
            <location evidence="1 8">Spindle pole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
            <location evidence="8">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
            <location evidence="8">Cytoskeleton</location>
            <location evidence="8">Spindle</location>
        </subcellularLocation>
        <text evidence="8">Localizes within the cytoplasm, partially overlapping with microtubules in interphase and to the mitotic spindle and spindle poles during mitosis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 2 sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.1" evidence="8"/>
    <dbReference type="EMBL" id="JAFHLR010000013">
        <property type="protein sequence ID" value="KAG5484361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HU94"/>
    <dbReference type="SMR" id="A0A836HU94"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008568">
        <property type="term" value="F:microtubule severing ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051013">
        <property type="term" value="P:microtubule severing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000434">
        <property type="entry name" value="Katanin p60 ATPase-containing subunit A-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03025">
        <property type="entry name" value="Katanin_p60_AL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027497">
        <property type="entry name" value="Katanin_p60_AL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF78">
        <property type="entry name" value="KATANIN P60 ATPASE-CONTAINING SUBUNIT A-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
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    <keyword evidence="7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="10">
        <location>
            <begin position="333"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="134"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="207"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="234"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="341"/>
            <end position="348"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5484361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="587" mass="63299" checksum="E450A5514B1A4262" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HVP4</accession>
    <name>A0A836HVP4_9TRYP</name>
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        <recommendedName>
            <fullName evidence="11 12">Elongation of fatty acids protein</fullName>
            <ecNumber evidence="12">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LSCM4_04898</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <reaction evidence="12">
            <text>an acyl-CoA + malonyl-CoA + H(+) = a 3-oxoacyl-CoA + CO2 + CoA</text>
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            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:50253"/>
        </physiologicalReaction>
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    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="12"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="GeneID" id="92360809"/>
    <dbReference type="KEGG" id="loi:92360809"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF17">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 6"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6 12" id="KW-0276">Fatty acid metabolism</keyword>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="381" mass="44569" checksum="30A8302A95727F6E" modified="2021-09-29" version="1">MKTLGGLWESVSVYPHNFKSEHGRAFLDRYPDYPVYATIVFLLVVFHLPGYVERHRIQLPIRYLVAAWNLFFSLVSIYGTFHVTMQIPYLLRARTPHNAMCELPSGDGRDDNVVSRRAAIVHAHRQQLMERGVVFKWERTPAEIQRRDAALFYDGPGAFAITMFAYLKTPELLDTLFLVLQRKPVSFLHWYHHIVTAIYVWLSSYMPMPSGIFFCAMNYFVHSIMYFYYFLVMMGLRKSIRPFAPVITLLQVLQMFIGMYITVYTYFQYWLSPEYSNTLFFQFFDVVLRNAYYIYYSAKSVVTTGAMASQVPSYDMADHFWGCDSDPTSMRMGMLMYGSYCVLFAVLFKELYLDKRVHKNSLVRVRASEDVKRAEAAKKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836I3F5</accession>
    <name>A0A836I3F5_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_07762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000006">
        <property type="protein sequence ID" value="KAG5487273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065770.1">
        <property type="nucleotide sequence ID" value="XM_067209640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836I3F5"/>
    <dbReference type="GeneID" id="92363574"/>
    <dbReference type="KEGG" id="loi:92363574"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="336"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5487273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="568" mass="60753" checksum="00032C935BDAED80" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836I3K6</accession>
    <name>A0A836I3K6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">coproporphyrinogen oxidase</fullName>
            <ecNumber evidence="5">1.3.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_07838</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>coproporphyrinogen III + O2 + 2 H(+) = protoporphyrinogen IX + 2 CO2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:18257"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57307"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="EC" id="1.3.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the aerobic coproporphyrinogen-III oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.3" evidence="5"/>
    <dbReference type="EMBL" id="JAFHLR010000006">
        <property type="protein sequence ID" value="KAG5487348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065845.1">
        <property type="nucleotide sequence ID" value="XM_067209715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836I3K6"/>
    <dbReference type="SMR" id="A0A836I3K6"/>
    <dbReference type="GeneID" id="92363649"/>
    <dbReference type="KEGG" id="loi:92363649"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00322"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1500.10:FF:000001">
        <property type="entry name" value="Oxygen-dependent coproporphyrinogen-III oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1500.10">
        <property type="entry name" value="Coproporphyrinogen III oxidase, aerobic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00333">
        <property type="entry name" value="Coprogen_oxidas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001260">
        <property type="entry name" value="Coprogen_oxidase_aer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036406">
        <property type="entry name" value="Coprogen_oxidase_aer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018375">
        <property type="entry name" value="Coprogen_oxidase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003727">
        <property type="entry name" value="PRK05330.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755">
        <property type="entry name" value="COPROPORPHYRINOGEN III OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755:SF0">
        <property type="entry name" value="OXYGEN-DEPENDENT COPROPORPHYRINOGEN-III OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01218">
        <property type="entry name" value="Coprogen_oxidas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000166">
        <property type="entry name" value="Coproporphyri_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00073">
        <property type="entry name" value="COPRGNOXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102886">
        <property type="entry name" value="Coproporphyrinogen III oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01021">
        <property type="entry name" value="COPROGEN_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00059657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5487348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="301" mass="34291" checksum="55F19BEBD302B399" modified="2021-09-29" version="1">MSLAVEPVKEFLLKLQNDICQALEVEDGKATFTEDRWAREGGGGGRTRVIQDGAVIEKGGVSFSHVYGKGLPGSSTERHPDMAGCNFQAMGVSLVIHPKNPHVPTSHANVRLFVAEKEGKEPVWWFGGGFDLTPYYAVEEDCCHFHKVAQELCKPFGADVYARFKAWCDEYFFIPYRNEARGIGGLFFDDLNEWPFEKCFEFMQAVGNGYIDAYIPIVSRRKNTPYTEEQVEFQEFRRGRYAEFNLAIDRGTKFGLQCGGRAESILMSLPPRARWGYNWHPEPGTPEARLTEYFLTKRQWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836I4K9</accession>
    <name>A0A836I4K9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NEDD8-activating enzyme E1 catalytic subunit</fullName>
            <ecNumber evidence="4">6.2.1.64</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_08368</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ATP + [NEDD8 protein] + [E1 NEDD8-activating enzyme]-L-cysteine = AMP + diphosphate + [E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine.</text>
            <dbReference type="EC" id="6.2.1.64"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.64" evidence="4"/>
    <dbReference type="EMBL" id="JAFHLR010000001">
        <property type="protein sequence ID" value="KAG5488290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066337.1">
        <property type="nucleotide sequence ID" value="XM_067210236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836I4K9"/>
    <dbReference type="SMR" id="A0A836I4K9"/>
    <dbReference type="GeneID" id="92364170"/>
    <dbReference type="KEGG" id="loi:92364170"/>
    <dbReference type="UniPathway" id="UPA00885"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.520:FF:000009">
        <property type="entry name" value="Ubiquitin activating enzyme, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.520">
        <property type="entry name" value="Ubiquitin activating enzymes (Uba3). Chain: B, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023318">
        <property type="entry name" value="Ub_act_enz_dom_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF6">
        <property type="entry name" value="NEDD8-ACTIVATING ENZYME E1 CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="6">
        <location>
            <begin position="34"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="276"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="481"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="298"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="481"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5488290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="554" mass="58097" checksum="79FFC91340FCC1C8" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836K6J6</accession>
    <name>A0A836K6J6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Adenosylhomocysteinase</fullName>
            <ecNumber evidence="6 7">3.13.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_00422</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine</text>
            <dbReference type="Rhea" id="RHEA:21708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="3.13.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="7">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.13.2.1" evidence="6 7"/>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058605.1">
        <property type="nucleotide sequence ID" value="XM_067202504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836K6J6"/>
    <dbReference type="SMR" id="A0A836K6J6"/>
    <dbReference type="GeneID" id="92356438"/>
    <dbReference type="KEGG" id="loi:92356438"/>
    <dbReference type="UniPathway" id="UPA00314">
        <property type="reaction ID" value="UER00076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004013">
        <property type="term" value="F:adenosylhomocysteinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033353">
        <property type="term" value="P:S-adenosylmethionine cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00401">
        <property type="entry name" value="SAHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1480:FF:000012">
        <property type="entry name" value="Adenosylhomocysteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000004">
        <property type="entry name" value="Adenosylhomocysteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00563">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00936">
        <property type="entry name" value="ahcY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004005">
        <property type="entry name" value="PRK05476.2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420:SF0">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00738">
        <property type="entry name" value="ADOHCYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0520">NAD</keyword>
    <keyword evidence="3 7" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S-adenosyl-L-homocysteine hydrolase NAD binding" evidence="9">
        <location>
            <begin position="342"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5464974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="589" mass="64558" checksum="4D90B73094184163" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KBF1</accession>
    <name>A0A836KBF1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_01194</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058947.1">
        <property type="nucleotide sequence ID" value="XM_067203256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KBF1"/>
    <dbReference type="GeneID" id="92357190"/>
    <dbReference type="KEGG" id="loi:92357190"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5466057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="31831" checksum="C6CACC5D7C8D9F62" modified="2021-09-29" version="1">MSSVLTAALAYGSSVFTIFALYPYRDFVKSVDVRHLPRAKDLGYYFAKRYRGMLGSPSQPMMLAAPHAALYFGYVFAAGGAAGGLLGGFLLGYTKTFVRAVAHRMNDGDSRYRKLGQRGYSGLLDCIMLSMKHYGMLSFFPGALAASAVGVLWYGISLAVLQQTHSRSFGEDLWNSFRIHALLTFLTAPVRNTMRSSTYHSERSGGVHALRDYVAAEVAVFREAAGVFRSSAREEGLRFFFDGVLRTTLKSSVPFALTYALFKVMGGSIGLPSGGTYRVAHTGRHFSRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KBT1</accession>
    <name>A0A836KBT1_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059397.1">
        <property type="nucleotide sequence ID" value="XM_067203706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KBT1"/>
    <dbReference type="GeneID" id="92357640"/>
    <dbReference type="KEGG" id="loi:92357640"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5466507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="153" mass="16876" checksum="6200488C08484A0E" modified="2021-09-29" version="1">MPRPAKRVSFGSLTPLSASPIEDSEGIDLRDSSRLLDAPPSHTWMHGSPQVATVSAATPPLVHNAAGTSSGRKSRTNTRRSQPYSAAHGWKEPTHRCRLLGRRPMTPGWTIEEEAISRIQKRRHRRAGLPLAHLSVIEGPPTTTHTIRQWSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KDU8</accession>
    <name>A0A836KDU8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-N-acetylglucosamine transferase subunit ALG14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_01975</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ALG14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061050.1">
        <property type="nucleotide sequence ID" value="XM_067204013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KDU8"/>
    <dbReference type="GeneID" id="92357947"/>
    <dbReference type="KEGG" id="loi:92357947"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043541">
        <property type="term" value="C:UDP-N-acetylglucosamine transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004577">
        <property type="term" value="F:N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013969">
        <property type="entry name" value="Oligosacch_biosynth_Alg14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12154">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12154:SF4">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE TRANSFERASE SUBUNIT ALG14 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08660">
        <property type="entry name" value="Alg14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032522914" description="UDP-N-acetylglucosamine transferase subunit ALG14" evidence="8">
        <location>
            <begin position="24"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 28 C-terminal" evidence="9">
        <location>
            <begin position="245"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5472654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="437" mass="47355" checksum="D7A0ABAB37E3C982" modified="2021-09-29" version="1">MWLLVALFLACAFLASLWHSAVCYVPLALRSPHRGPMKVGVVLGSGGHTSEMLRIITELPGSYWSGTRPFYVVSATDAHSRSLASQLEQERFERSAIVYTIPRAREVGQSYLTSTATTLKATFACFRLVCVEKPDVLLTNGPGVCVPVIAAAFCVALCAPWWYGRPAIVYMESFTCVSHLSLTGRLLAPWLADVFTVHWRALERVVARRRRRGTLVYFGSEESQVTDGAEHRLGSLAAVQEAYALVTVGSTRFPSLVTAMVQPGICAALRQRFGIERLYVQHGTAEVVAPAEAIFPSAPSATAGADASHPTQQWSCGGLLVEAFPYRPHLDAVIRGATLVITHAGAGTILEGLQAQRALVVVPNRQLMSDHQLELAEALAAGGFLFCVQVAELAERLPLLDVTTLRPHRGTDAAQLEEALRLVLTGHCASEERTKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KER6</accession>
    <name>A0A836KER6_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_03608</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061542.1">
        <property type="nucleotide sequence ID" value="XM_067205605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KER6"/>
    <dbReference type="GeneID" id="92359539"/>
    <dbReference type="KEGG" id="loi:92359539"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5473539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="101" mass="11339" checksum="93C94D31EC41CCF3" modified="2021-09-29" version="1">MALLDTSCNAIENVAQIVMRVREIELGLRKGSLHGHRRDCPFPRITTELSESAQAGNTVPAQHSLVTVDTADNETLRGIEWRVHLWEPSHGAREAREEPRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KF23</accession>
    <name>A0A836KF23_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Membrane transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_03155</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">LSCM4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060723.1">
        <property type="nucleotide sequence ID" value="XM_067205171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KF23"/>
    <dbReference type="SMR" id="A0A836KF23"/>
    <dbReference type="GeneID" id="92359105"/>
    <dbReference type="KEGG" id="loi:92359105"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576:SF157">
        <property type="entry name" value="NODULIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576">
        <property type="entry name" value="UNCHARACTERIZED NODULIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="718"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="757"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="790"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="821"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="856"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="902"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="465"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="597"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="485"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="503"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="625"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5471606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="981" mass="108164" checksum="7E8C0E3A536ED569" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KF85</accession>
    <name>A0A836KF85_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_03355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060918.1">
        <property type="nucleotide sequence ID" value="XM_067205366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KF85"/>
    <dbReference type="GeneID" id="92359300"/>
    <dbReference type="KEGG" id="loi:92359300"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5471801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="176" mass="19905" checksum="F95513D167257F4F" modified="2021-09-29" version="1">MPQFVVKKSSRVGEEVWTTRVLTVDEEYHILYLSKRSDASQMDHHCMVSIREVEVFPAYSSTFHTAAYLPSGAWQAISIRGSTITLGYSSPLNRLLQIGTRKMTPMEHRSLKASRKKLLGGEEPFDSESLVKATVVSNEEWMLQCMTKKDLRYLLKSLCAAVVDPTCVKGPKVRLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KGV3</accession>
    <name>A0A836KGV3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VHS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_00550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058729.1">
        <property type="nucleotide sequence ID" value="XM_067202628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KGV3"/>
    <dbReference type="SMR" id="A0A836KGV3"/>
    <dbReference type="GeneID" id="92356562"/>
    <dbReference type="KEGG" id="loi:92356562"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03561">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044836">
        <property type="entry name" value="TOL_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45898:SF4">
        <property type="entry name" value="TARGET OF MYB PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45898">
        <property type="entry name" value="TOM1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VHS" evidence="2">
        <location>
            <begin position="29"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="349"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5465098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="520" mass="56598" checksum="67E95D70A9BF8254" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KHD4</accession>
    <name>A0A836KHD4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">10 kDa heat shock protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_05045</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GroES chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062322.1">
        <property type="nucleotide sequence ID" value="XM_067207019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KHD4"/>
    <dbReference type="SMR" id="A0A836KHD4"/>
    <dbReference type="GeneID" id="92360953"/>
    <dbReference type="KEGG" id="loi:92360953"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.33.40:FF:000014">
        <property type="entry name" value="10 kDa heat shock protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="entry name" value="GroES chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772:SF0">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5476089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="100" mass="10733" checksum="944588A6AFCB44A9" modified="2021-09-29" version="1">MFRFTAPALKKLQPLGQRVLVKRMQAAKQTKAGILIPEQVAGKVNEGTVVAVAAGSKDWTPTVKVNDTVLLPEYGGSAVKVDGEELYLYDESMLLGVLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KHS8</accession>
    <name>A0A836KHS8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ankyrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_01210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058963.1">
        <property type="nucleotide sequence ID" value="XM_067203272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KHS8"/>
    <dbReference type="SMR" id="A0A836KHS8"/>
    <dbReference type="GeneID" id="92357206"/>
    <dbReference type="KEGG" id="loi:92357206"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24183">
        <property type="entry name" value="FIBRONECTIN TYPE 3 AND ANKYRIN REPEAT DOMAINS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24183:SF1">
        <property type="entry name" value="FIBRONECTIN TYPE 3 AND ANKYRIN REPEAT DOMAINS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="216"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="249"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="327"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="418"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5466073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="427" mass="46102" checksum="5C325386BB3694A1" modified="2021-09-29" version="1">MQRKYTNAQALAVYQALQQSGGLSALEDDTATALYLSQNAAATGELSFTPGLLERLTKRLDKGGMVLDPFCSYDYADRRHIRNFSMSIPIPFSAFDGIRRSKHQVQLTAAQEENVLKSFDKLLNGEDARKNGATPASKGAREISVALPFVSAFFDQRCPELHNSALKGSREGATYLLLSVITGHKELCTKCLKAGANPNNMSFLRDESPAPGDMFHGYSPVFMAVLSEQIEILELLCSCGGSIHVYDRWGRTPLHAAMAVESTATVQWLLAKGAPLYVPDGFGILPADSCVGTQYAEYSMPMLALQEPPKGPPPSYFAEAAKGWATPEPGSNATAENKSKKGAAVTSSGASTTEEEATMELCRCRSGRPVGYCGCIDDMLVRWARDRLNTEWSPGVNFSALAKKQAAAEEERKRATYGAGGNRGGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KIM2</accession>
    <name>A0A836KIM2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">arginine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Arginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LSCM4_04208</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Arg) + L-arginine + ATP = L-arginyl-tRNA(Arg) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="3"/>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062134.1">
        <property type="nucleotide sequence ID" value="XM_067206197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KIM2"/>
    <dbReference type="SMR" id="A0A836KIM2"/>
    <dbReference type="GeneID" id="92360131"/>
    <dbReference type="KEGG" id="loi:92360131"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000008">
        <property type="entry name" value="Arginine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.70:FF:000010">
        <property type="entry name" value="Arginyl-tRNA synthetase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="entry name" value="Arginyl tRNA synthetase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00123">
        <property type="entry name" value="Arg_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956:SF5">
        <property type="entry name" value="ARGININE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="ARGINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03485">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arginyl tRNA synthetase N-terminal" evidence="14">
        <location>
            <begin position="12"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="DALR anticodon binding" evidence="13">
        <location>
            <begin position="577"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG5475626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="692" mass="78290" checksum="7576ADC20E79CD02" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KIM3</accession>
    <name>A0A836KIM3_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_04477</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat mio family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062670.1">
        <property type="nucleotide sequence ID" value="XM_067206461.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92360395"/>
    <dbReference type="KEGG" id="loi:92360395"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16691">
        <property type="entry name" value="mRING-H2-C3H3C2_Mio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037593">
        <property type="entry name" value="MIOS/Sea4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031488">
        <property type="entry name" value="Zn_ribbon_mio"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16453:SF13">
        <property type="entry name" value="WD REPEAT PROTEIN MIO ZINC-RIBBON LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16453">
        <property type="entry name" value="WD40 DOMAIN-CONTAINING PROTEIN MIO FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="336"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="764"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1250"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1822"/>
            <end position="1865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2055"/>
            <end position="2097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="336"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="399"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1255"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2068"/>
            <end position="2082"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5477259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="2276" mass="233100" checksum="1ADD7C83FF4940C8" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KJ84</accession>
    <name>A0A836KJ84_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_04072</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061998.1">
        <property type="nucleotide sequence ID" value="XM_067206061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KJ84"/>
    <dbReference type="SMR" id="A0A836KJ84"/>
    <dbReference type="GeneID" id="92359995"/>
    <dbReference type="KEGG" id="loi:92359995"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF98">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="12"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5474892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="383" mass="42807" checksum="499E8CD9439A400E" modified="2021-09-29" version="1">MEIAADFARRGLRFVDFLGCGAFGDTYLVRDASGACLAVKRSRSLVKQSGVLEEYLGMMDLCSLHVVASHDAWIDRESRVCILMDYCDAGDLEGYMKKGYPLPEEEVLSIVTQLLLGLDHIHKKNRVHRDIKPENIFLSSAKAGGGRWPVVRLGDFGTVKRLSYWGARVVSRVGTPLYLAPEIVAGYAYTSKADIWSMGLVVYRLMVNRLPFRTTSVDAHTRRVLHLSPPHPSTLSGYSRALGECVMAMLSRNWKRRPSAEALLRCDVFQSTSLQHLWIRAPPQASPCLFVRRRTSLLAVHAAPSERSQALRALEFGDQVYLSSCDSMNRLHRGEWVELLHPVAGFIRDAVETEVLLDSYTSNECTVTVGSLTRLLDGVPKHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KKT2</accession>
    <name>A0A836KKT2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA replication licensing factor MCM5</fullName>
            <ecNumber evidence="12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LSCM4_05377</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5477981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062888.1">
        <property type="nucleotide sequence ID" value="XM_067207320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KKT2"/>
    <dbReference type="SMR" id="A0A836KKT2"/>
    <dbReference type="GeneID" id="92361254"/>
    <dbReference type="KEGG" id="loi:92361254"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000025">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001327">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008048">
        <property type="entry name" value="MCM5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054125">
        <property type="entry name" value="MCM5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF42">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21933">
        <property type="entry name" value="MCM5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01661">
        <property type="entry name" value="MCMPROTEIN5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="14">
        <location>
            <begin position="361"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="569"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="581"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG5477981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="799" mass="86801" checksum="B026233A8CF444D4" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KL89</accession>
    <name>A0A836KL89_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_04359</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062553.1">
        <property type="nucleotide sequence ID" value="XM_067206344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KL89"/>
    <dbReference type="GeneID" id="92360278"/>
    <dbReference type="KEGG" id="loi:92360278"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5477142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1048" mass="113866" checksum="526E4A203750D405" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KLY4</accession>
    <name>A0A836KLY4_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000020">
        <property type="protein sequence ID" value="KAG5480409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063740.1">
        <property type="nucleotide sequence ID" value="XM_067208100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KLY4"/>
    <dbReference type="GeneID" id="92362034"/>
    <dbReference type="KEGG" id="loi:92362034"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="662"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="323"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="453"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="575"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="590"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5480409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="681" mass="70231" checksum="2441C991CD05CE34" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KMI1</accession>
    <name>A0A836KMI1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome production factor 2 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ribosome biogenesis protein RPF2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_04985</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
            <location evidence="1 4">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the RPF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062263.1">
        <property type="nucleotide sequence ID" value="XM_067206960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KMI1"/>
    <dbReference type="SMR" id="A0A836KMI1"/>
    <dbReference type="GeneID" id="92360894"/>
    <dbReference type="KEGG" id="loi:92360894"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039770">
        <property type="entry name" value="Rpf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728">
        <property type="entry name" value="BRIX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728:SF0">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="6">
        <location>
            <begin position="33"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="321"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="348"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5476030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="362" mass="40481" checksum="E95BB73B56267613" modified="2021-09-29" version="1">MSAVGGFKRRTPKTATTRRAVKHYEPKIVENAKRVLFLRGASSNEVVTDAMVDLMAITKPYCKRLVKKNAFFPFDGRQHLEFLGFKNDCSLFCFGSSNKKRPNNITIGRQFDFHVLDMVELGIVAADRLDMSQTVGVDAGSVGGKPFFVFEGSEFTSDPAFMRLKNLLVDYFRGSNDVEINLDGCDRVLFFSLRSQNGEDAVVAPSTDCYTNKPPSEKGNAILCMRHYAVKKPSAASGVPKSIKNVQLYDVGPNFDFEIRRISFATPQEFKLACRIPRETLATLRSTAENVQSDGLNNLRGQLHVGKQDINELNLRRFKAHRRGATDGVSADEEAPEDESKPRRRRARVEADVGESRPETDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KNN1</accession>
    <name>A0A836KNN1_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063493.1">
        <property type="nucleotide sequence ID" value="XM_067207720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KNN1"/>
    <dbReference type="GeneID" id="92361654"/>
    <dbReference type="KEGG" id="loi:92361654"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5479782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="71" mass="7693" checksum="BD8CB3031E28B4EF" modified="2021-09-29" version="1">MDFQFITDLDLLFPIASLVLAAVTALLIGGFIPHKRAVSSSHSECGHTKDDKAMEKVTATQTYKVAKVAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KNU0</accession>
    <name>A0A836KNU0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_04584</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062776.1">
        <property type="nucleotide sequence ID" value="XM_067206567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KNU0"/>
    <dbReference type="GeneID" id="92360501"/>
    <dbReference type="KEGG" id="loi:92360501"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5477365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="174" mass="18776" checksum="B9809C6ABFB0FE92" modified="2021-09-29" version="1">MDPALSVMSPFQYEAKGIDGMLEDAVEEITRPSPIGASSSNSGGNMRTLVASDGAAVEPPASAALHVTYCIFCAQSTTIRSVPKGGMYVCANCLAEQGSRPRLFPLGTFKCCPTSTEAVDGDVVRCAGCYRWYHAHCVGIVDSVLRNYVTLSTTSWYCPEPACCDRVLQRHLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KP06</accession>
    <name>A0A836KP06_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Coenzyme Q-binding protein COQ10 START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_05647</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with coenzyme Q.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the COQ10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000016">
        <property type="protein sequence ID" value="KAG5482389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064395.1">
        <property type="nucleotide sequence ID" value="XM_067207581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KP06"/>
    <dbReference type="GeneID" id="92361515"/>
    <dbReference type="KEGG" id="loi:92361515"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07813">
        <property type="entry name" value="COQ10p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044996">
        <property type="entry name" value="COQ10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901:SF10">
        <property type="entry name" value="COENZYME Q-BINDING PROTEIN COQ10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901">
        <property type="entry name" value="SPERM PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Coenzyme Q-binding protein COQ10 START" evidence="5">
        <location>
            <begin position="286"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="243"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="141"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="397"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5482389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="520" mass="54660" checksum="E23CC9AA64870133" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KQG6</accession>
    <name>A0A836KQG6_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_04954</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000014">
        <property type="protein sequence ID" value="KAG5483799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064738.1">
        <property type="nucleotide sequence ID" value="XM_067206929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KQG6"/>
    <dbReference type="GeneID" id="92360863"/>
    <dbReference type="KEGG" id="loi:92360863"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32083">
        <property type="entry name" value="CILIA AND FLAGELLA-ASSOCIATED PROTEIN 58-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32083:SF48">
        <property type="entry name" value="TRANS-GOLGI NETWORK-LOCALIZED SYP41-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="142"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="231"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="626"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="879"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="31"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="470"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="655"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="155"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="879"/>
            <end position="900"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5483799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="944" mass="101471" checksum="D4DFF08D0A3F8761" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KQS8</accession>
    <name>A0A836KQS8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Divalent cation transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_03949</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061879.1">
        <property type="nucleotide sequence ID" value="XM_067205942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KQS8"/>
    <dbReference type="SMR" id="A0A836KQS8"/>
    <dbReference type="GeneID" id="92359876"/>
    <dbReference type="KEGG" id="loi:92359876"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
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                <person name="Gatherer D."/>
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            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="494" mass="54972" checksum="44C3AA3AF940FF1C" modified="2021-09-29" version="1">MWRCICFACTCAGRSISGVALPPTLREANASSTTRLYQQCLDPMNSPGNVSRLAAALLPRIDSGELALHQQAQLLQTLAARSIRNEDVMLKCLWTVFKAPLPADHDSFAETSKTMRCASLSKLSGITSSAFQVMAEQRFLNDPQMTAVALGRCVELIPYASLEGLRSIYCGLRAVSHMFFSVAEVAHHRSEVTEQMTTKEFYEAEDLPDEETLRHQPNLLDVLCGEVELRLRHLCDAFARAAPDPMEMTNALPASIATGASLAPSIARDTHEAQWFLDVLDALAVVGVLHASTLDSLTGLLSRCRINSSAGFFIEALTHATRIEERVVDPLTYEESAAVRDARRRLTLNLSEAIQKARNIHGYLRHHPQELLLLRRLFERDTAEPFLSLALWDTVRTIRVAHCHTIAASQASRRPAGALFQKLYNVKVKPISVDNSEAERFVPPEFKTWRSPAASPRGGHRRNGRSPTRAAFGTRRISKNYIKNKRKKFCPAVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KRL8</accession>
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        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
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        <name type="scientific">Leishmania orientalis</name>
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    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067206244.1"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
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    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="CLK_kinases"/>
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        <property type="entry name" value="Protein_kinase_ATP_BS"/>
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        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Pkinase"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ST"/>
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    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
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    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
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            <begin position="20"/>
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        </location>
    </feature>
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        <ligand>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5475673.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Bates M.D."/>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5486140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="20324" checksum="4D2F1FA9AE531A88" modified="2021-09-29" version="1">MGSGGSKACASRGAELPRYEDDPPKSTNIGDLVLSGRYKVASPETVEMMKQIQSPRDANKMYPDSEVKDLKQYIIEQEGLEIGQGRRRALSQQWRFFLSCEPMQRGLDAGIILGSFSAFVASRRPRNRVPAKIALIFFGGFCGGMLSVPLMVVATDAYNSQRIKKLEQELFEKQRSEFHKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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        <name evidence="3" type="ORF">LSCM4_06280</name>
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        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Trypanosomatida</taxon>
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            <taxon>Leishmania</taxon>
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    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5486815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="598" mass="66300" checksum="342CED34828B2144" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KYX6</accession>
    <name>A0A836KYX6_9TRYP</name>
    <protein>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">LSCM4_08285</name>
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    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <location>
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        <location>
            <begin position="1110"/>
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        <location>
            <begin position="10"/>
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        </location>
    </feature>
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        <location>
            <begin position="169"/>
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        </location>
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        <location>
            <begin position="1121"/>
            <end position="1131"/>
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            <dbReference type="EMBL" id="KAG5488060.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1520" mass="162136" checksum="9A39FC5E0583EE18" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000001">
        <property type="protein sequence ID" value="KAG5488240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067210186.1"/>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5488240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="295" mass="32961" checksum="2B54ECACDDA16822" modified="2021-09-29" version="1">MPLLYVRRPCRHLHTGSHRHTHRRSAMSGCRGIIVAGVTNRARTQMAEALLRAFTGGRVFVCSGGVHHLGTVHPLAVATMAEIGIDVSRQSSSSLAGVRRQRDTYDVYVSVDAPYTERASDRYQRRYTDAHAAGERSIGGAGVSASCSPPCSSGVDFYDPMLALSTPAHWRVAQDATDGRQSWTLWSPRDPAIYHERSARKLQDHLYEGEPLFMRVRPHELRKACRVQRRWEVPEITQRFALETEAEQKVRFVRARDVIGSLALALVRDLEREYGETMLDEATVAAYEAVATTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G021</accession>
    <name>A0A836G021_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Adiponectin receptor protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_00588</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067202666.1"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A836G021"/>
    <dbReference type="GeneID" id="92356600"/>
    <dbReference type="KEGG" id="loi:92356600"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF52">
        <property type="entry name" value="ADIPONECTIN RECEPTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="372"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="429"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="173"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="469"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5465136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="502" mass="56111" checksum="2275202064DC3702" modified="2021-09-29" version="1">MSLKATSITLEGNAPHRSSLKVDSEDDRVLLDSRENESLPFDSTAVSLPPAPLPYRYVARTLHTAASDQQRDWSESGESSPVDFEAYSLTEMVATPPFIPTERQHNFFMRDTDSQSGGDGDTHMMVRLRLDTSQTSAVNFDAVIVGPHDTTSASAAALSAVSSVSLNAAETSLQREEPVTDAKTSEHGGRRRKRRFSLVAKAPPFDPAREQQWNLLTRGREHVLPLYHFDEIPHWQRYNPHIRGGYRAFYTAKMCFESLLGWHNETINVYSHLLTFVAFLVFTMLLYTTVLSKAITAPSLSSSKLIYGIFCFGCLLCMLNSSLYHLFNGHCSCRVMTAMGRLDFIGITVLIVSSFLPPLYVIFHCNPVVRTVYMASILVLGMAGIVGPWTDLFHEHVWVRLSVFLGLGFSGLVPVVHSLTIVPLNSASISTVLGILLMVLLYCSGVAFYVTQFPESRYPGHFDCWLSSHQLWHFFVSMAALVHYFNCVSMYQMWQVSDGMCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G1R6</accession>
    <name>A0A836G1R6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ADF-H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_03493</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin-binding proteins ADF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061430.1">
        <property type="nucleotide sequence ID" value="XM_067205493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G1R6"/>
    <dbReference type="SMR" id="A0A836G1R6"/>
    <dbReference type="GeneID" id="92359427"/>
    <dbReference type="KEGG" id="loi:92359427"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11286">
        <property type="entry name" value="ADF_cofilin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017904">
        <property type="entry name" value="ADF/Cofilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11913">
        <property type="entry name" value="COFILIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="3">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5473427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="139" mass="15602" checksum="B078D7708CEE74CF" modified="2021-09-29" version="1">MAMSGVTLQDGVPGAINDLRMKKCRYVLMTIGADGRQIEVTEIGERSVTYAAFKEKMAADKPCYVAFDFEYADAGSNREKLILIQWIPDTAKPREKMMYSASRDALSSVAEGYLPIQANEMSELEMEEVVRKVKIHRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G7K9</accession>
    <name>A0A836G7K9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_01041</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059756.1">
        <property type="nucleotide sequence ID" value="XM_067203106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G7K9"/>
    <dbReference type="GeneID" id="92357040"/>
    <dbReference type="KEGG" id="loi:92357040"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="3">
        <location>
            <begin position="122"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="189"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="198"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5467954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="29523" checksum="CC72F53079E03DA5" modified="2021-09-29" version="1">MSRSRHTERRESRRERRKESRHSVKKHHHHRSSGSSSRHRHSVISEKPPVPRDFHCHICGKAHWTVYCDRLQRHPEHYPLMDAERGCRQCGQQGHSASQCRIKKYLCRDCGGMHDTRDCAFAHVGEDWYEFFDPKTRHVYYANSDESQIQWNPPTHELDTVYWYCSRCQVMISAKFRECLLCHSIRPESKPQDTLTADSDSSISSSSSASSSSSGEGDSSYTTGSSSSSSSSGSDSVFDSSSSDDDDEQGQSVKPDGRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G931</accession>
    <name>A0A836G931_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_00803</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059526.1">
        <property type="nucleotide sequence ID" value="XM_067202876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G931"/>
    <dbReference type="SMR" id="A0A836G931"/>
    <dbReference type="GeneID" id="92356810"/>
    <dbReference type="KEGG" id="loi:92356810"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000678">
        <property type="entry name" value="Ribosomal protein S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004977">
        <property type="entry name" value="Ribosomal_eS25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12850">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03297">
        <property type="entry name" value="Ribosomal_S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5467724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="120" mass="13045" checksum="12D910117908B4CB" modified="2021-09-29" version="1">MPPKAGQTKKAKMEAANKGAKKTTKKWSKGQSREALQNAVMFDKETYDKLRSEVPKYKLITPSIISDRLKIAVSIAAAGLKQLCREKLIRLVSCSSKTRVYTRIVQAAPAEAAAAAPAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GD24</accession>
    <name>A0A836GD24_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Golgi SNARE protein-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_00435</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GOSR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058618.1">
        <property type="nucleotide sequence ID" value="XM_067202517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GD24"/>
    <dbReference type="SMR" id="A0A836GD24"/>
    <dbReference type="GeneID" id="92356451"/>
    <dbReference type="KEGG" id="loi:92356451"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048219">
        <property type="term" value="P:inter-Golgi cisterna vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023601">
        <property type="entry name" value="Golgi_SNAP_su1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21094:SF2">
        <property type="entry name" value="GOLGI SNAP RECEPTOR COMPLEX MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21094">
        <property type="entry name" value="GOS-28 SNARE- RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="257"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="201"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5464987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="31428" checksum="CEC5D3815C16E3C8" modified="2021-09-29" version="1">MDPEARQVASWERLRNEARQVDQLIERQLRKLEVVALFNDEKLIGYTATSATKGVGSSDLVSPAVPSTSSSLLHGSGSSPITASTMSFEDLESQYRGADRDIDESLRRLEQTVLSMEEVCRELGPTSAVARHTERFRGVLTERQQTRHRLSTEFQQRKDRYELSASRLVGDAQRRSGFGDDDASSGVRILMDEQASIQHTLNRVNGLLEQAEGTRDRLRMQRERFNEISDKLLHIAERIPFVQNVLRRIDVRRRREVVVLSTIMSSLMFMLVFFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GF71</accession>
    <name>A0A836GF71_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Chaperone protein DNAj</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_01485</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059227.1">
        <property type="nucleotide sequence ID" value="XM_067203536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GF71"/>
    <dbReference type="SMR" id="A0A836GF71"/>
    <dbReference type="GeneID" id="92357470"/>
    <dbReference type="KEGG" id="loi:92357470"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000013">
        <property type="entry name" value="DnaJ subfamily B member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
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    </dbReference>
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        <property type="entry name" value="DnaJ_C"/>
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    </dbReference>
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        <property type="entry name" value="DnaJ_CXXCXGXG"/>
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    </dbReference>
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        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DNAJ_1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
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            <begin position="48"/>
            <end position="109"/>
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        <location>
            <begin position="185"/>
            <end position="270"/>
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        <location>
            <begin position="185"/>
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            <begin position="429"/>
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        </location>
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            <begin position="429"/>
            <end position="439"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="6">
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            <begin position="458"/>
            <end position="469"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00022723"/>
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            <dbReference type="ARBA" id="ARBA00022737"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5466337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="478" mass="50985" checksum="648D857E8E74BFB2" modified="2021-09-29" version="1">MFRYLSASAARRACGLSAVAPLTAAPAGSSTFCSSTTPVRFYSSGSKDYYKMLGVDRNSDLKEIKKAYRKRALETHPDQGGSKEEFAEVAEAYEVLSNPEKRKVYDQYGSEAATNPNMGGAGMGGFGAGGRSAEDIFAEFFRGGMGGMGGFGDMFGGGPGGRQGTPTLQPLEVRTRLTLEDVYKGVTKTMRVNRPQVCSDCAGFGSKSRTEKPRCTQCNGSGHVVQQHRMGPGMVQQTITECPRCRGTGSMSKPEDQCPKCHGKGYRTVSQDVTVEIPAGVPSNVTLVVRGEGGTIPGAPPADMHLHIELSPHRVFQRRGNDLIVNKEVTLQEALLGLHMPLKLLDGRTVSIETSADQVLKPEGVIKVTGEGLPGTSGERGDVYIFTHLKMPNRLSNEQKEHIKKALGAPAKDADASPGNTVKARVMRESREQLEEQKRSLWASQESGGYSGVGGGSSRRTAGSTASGGAQQVECATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GFD9</accession>
    <name>A0A836GFD9_9TRYP</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    <gene>
        <name evidence="2" type="ORF">LSCM4_01623</name>
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        <name type="scientific">Leishmania orientalis</name>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059362.1">
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    </dbReference>
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    <dbReference type="GeneID" id="92357605"/>
    <dbReference type="KEGG" id="loi:92357605"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5466472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="908" mass="98930" checksum="FCE3FFE6E0C025A4" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GFU5</accession>
    <name>A0A836GFU5_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Discoba</taxon>
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            <taxon>Leishmania</taxon>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5472844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="199" mass="22404" checksum="2313B85E8AAAFB3E" modified="2021-09-29" version="1">MPYIAYPSAVSWSSTTQASSDAREDAFGHYATYRRVIRTVLCGILFATPLCAAIPLSPLLKLSQTQENKRSIIPRMMSDFFYVNFFASATAYWMLVEPFISNPKAKEGFVPYLGPVTAEIPAVSCLLTSHLFYPGLWAIVNEPTWQLRRREFVRLNVKCFVAFGPVHVPAAVALGATVGVVLYPFKHMKLRAQHRDEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GG75</accession>
    <name>A0A836GG75_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_00110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058301.1">
        <property type="nucleotide sequence ID" value="XM_067202200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GG75"/>
    <dbReference type="GeneID" id="92356134"/>
    <dbReference type="KEGG" id="loi:92356134"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033036312" evidence="1">
        <location>
            <begin position="24"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5464670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="153" mass="16857" checksum="57722D4174324C7D" modified="2021-09-29" version="1">MKPFLRTFAVLCIVAGVLQEGGAAWAPPRAVPPLETKFSSLSQACHGVLEKECPPDGVSRTDCLMEHIEGNDNHECKLWLAWRATCFATAIVNLIPNGLCNFTSDQATSKLIRRCLRHVDKNELPRACSASPYFKSLMLRAPRRMDSDAAGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GH06</accession>
    <name>A0A836GH06_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">A distinct subfamily of CDD/CDA-like deaminases protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_00633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058811.1">
        <property type="nucleotide sequence ID" value="XM_067202710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GH06"/>
    <dbReference type="GeneID" id="92356644"/>
    <dbReference type="KEGG" id="loi:92356644"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000102">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032723">
        <property type="entry name" value="Deaminase_LmjF365940"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14421">
        <property type="entry name" value="LmjF365940-deam"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5465180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="627" mass="69093" checksum="44507699B9151377" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GJC5</accession>
    <name>A0A836GJC5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GP-PDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_03971</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycerophosphoryl diester phosphodiesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061900.1">
        <property type="nucleotide sequence ID" value="XM_067205963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GJC5"/>
    <dbReference type="SMR" id="A0A836GJC5"/>
    <dbReference type="GeneID" id="92359897"/>
    <dbReference type="KEGG" id="loi:92359897"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000080">
        <property type="entry name" value="Glycerophosphoryl diester phosphodiesterase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052271">
        <property type="entry name" value="GDPD-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42758">
        <property type="entry name" value="PHOSPHATIDYLGLYCEROL PHOSPHOLIPASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42758:SF2">
        <property type="entry name" value="PHOSPHATIDYLGLYCEROL PHOSPHOLIPASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="9">
        <location>
            <begin position="43"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5474794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="349" mass="39964" checksum="403BD8B3F67166C2" modified="2021-09-29" version="1">MRALSTVALGMGAYLLVSFCLLKVTIRSKRREWLFKKKFPYPITKIAHRGGSLLGPENTLYTFMRVVQDGLCDMIELDVRESKDGQVVVLHDRTLERTCGPQYAGVSVSDLVVGKDPSKTLPQSKRTIDLEFTTRYVKQYEASDEVPVDDTTRICLLSEVFEKLPSMPLHIDIKDEGKDFVTLVLNLIATFDRESITIVGSSHQQNQRFINEYFAEREPEIRKRHRIFAGPHDFFRTYLLFYTGLLPYFSVNYDVFSIPVFTSTMKANASKSYGKLCASVCAFFFSSPLLWRYLQSRGVAVIGWNLNDEIDILQGIQWPLNGVMSDDPIKLRQLIDMNKRVARLKMVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GK33</accession>
    <name>A0A836GK33_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_02540</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060119.1">
        <property type="nucleotide sequence ID" value="XM_067204567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GK33"/>
    <dbReference type="SMR" id="A0A836GK33"/>
    <dbReference type="GeneID" id="92358501"/>
    <dbReference type="KEGG" id="loi:92358501"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00106">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000124">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF75">
        <property type="entry name" value="CENTROMERE-ASSOCIATED PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4 5 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="8">
        <location>
            <begin position="2"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="579"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="637"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="749"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="899"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="579"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="645"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="766"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="793"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="905"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="73"/>
            <end position="80"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5469142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="949" mass="105890" checksum="49D6352E13DD5768" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GNU3</accession>
    <name>A0A836GNU3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Palmitoyltransferase</fullName>
            <ecNumber evidence="8">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_04794</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family. PFA5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="8"/>
    <dbReference type="EMBL" id="JAFHLR010000023">
        <property type="protein sequence ID" value="KAG5478561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063222.1">
        <property type="nucleotide sequence ID" value="XM_067206775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GNU3"/>
    <dbReference type="GeneID" id="92360709"/>
    <dbReference type="KEGG" id="loi:92360709"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF23">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="400"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="10">
        <location>
            <begin position="323"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="151"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="251"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="151"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="255"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5478561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="514" mass="56037" checksum="DA8E47D573145483" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GPT0</accession>
    <name>A0A836GPT0_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060809.1">
        <property type="nucleotide sequence ID" value="XM_067205257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GPT0"/>
    <dbReference type="GeneID" id="92359191"/>
    <dbReference type="KEGG" id="loi:92359191"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="243"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5471692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="416" mass="44084" checksum="C196D0A88C3050DE" modified="2021-09-29" version="1">MSTMSMWQVTIGDGVHDKEHHHYDAIAWQQLLNNLDLTSESDSTSEDGVDAAPKSCPTPTIQLKQSNASAKDVTQWVKLDAHRTSSSRESPLGLPEDECSSEDEHKPPGDRIASGRSMKAVYSSPSTTFTTKSGSGDCAVPTQNSSGATAPCFFVNGARHSIEAPRKTPDWTAALSSSPSPAKRVSTESTRCASVPVDHFPTPAKTVVAGNASRRRSERVRTTKSAKQSKSSMNPPPYPMPGTPATGYAAPASPPSSGVRREVQSPFTLPNASSAYLANTAPAMQRFQASAMPTAQQASIPPLFWSNNGSTANAFSNSPILSLVLMDGEGGLHHASQGQTPSASAPPALPMVHAPGRATAPSGMPQVHYTPSTVQAEPWRPVAAPSTPLLCTRSSGLWGNTKAWVFRDNRWIALSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GQF1</accession>
    <name>A0A836GQF1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cullin family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_05524</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5478124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063031.1">
        <property type="nucleotide sequence ID" value="XM_067207463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GQF1"/>
    <dbReference type="SMR" id="A0A836GQF1"/>
    <dbReference type="GeneID" id="92361397"/>
    <dbReference type="KEGG" id="loi:92361397"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000065">
        <property type="entry name" value="Cullin-like protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000066">
        <property type="entry name" value="Cullin-like protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Cullin family profile" evidence="6">
        <location>
            <begin position="396"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5478124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="744" mass="85528" checksum="B2E86FE56ECAED54" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GQT2</accession>
    <name>A0A836GQT2_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_07394</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000008">
        <property type="protein sequence ID" value="KAG5486462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065528.1">
        <property type="nucleotide sequence ID" value="XM_067209285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GQT2"/>
    <dbReference type="GeneID" id="92363219"/>
    <dbReference type="KEGG" id="loi:92363219"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032765153" evidence="3">
        <location>
            <begin position="39"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5486462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="208" mass="22376" checksum="2053ACC6F371987C" modified="2021-09-29" version="1">MVSISACTRAPQRSRGSLTLLLTAAAWCFLSMLTPSETMAVAQGSASATTGNCSYTIWTPTPPPSEAPPTVYPPGAVAYQRHNYTTPPESFFTSSWYVAIILILCSVCGLYLLLALLIICHFDLRAQHQAQKVVEESYATKGCFNLDGKGAHGERMRATSSRGHSPSFVSSTSNNNDSSSYDDSSDGESPSLPSEADDTVIHVNPFQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GQY9</accession>
    <name>A0A836GQY9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_02884</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060456.1">
        <property type="nucleotide sequence ID" value="XM_067204904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GQY9"/>
    <dbReference type="SMR" id="A0A836GQY9"/>
    <dbReference type="GeneID" id="92358838"/>
    <dbReference type="KEGG" id="loi:92358838"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="10">
        <location>
            <begin position="50"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5470190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="223" mass="24516" checksum="1D97683EC538D863" modified="2021-09-29" version="1">MSMSTQRARSPLTAVVAVVTVGFLLISSISVLPARANDGGLAVQVPAGQQVCFYEDALAIGTKMFLHYMVTVGGAMDIDCSILAPDKTIIWNSDRETENRVLFKTRMPGSYAFCFSNRMSTLTSKVVSFSVLVGDGNAASSIRPKAVESDSLHRSIIRLQQGLREIEELQQVLRARERDHRATAEVANTRVVVFCFVESAFIVGMGVGSIIYLRRMFVTKRMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GS74</accession>
    <name>A0A836GS74_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5477984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062891.1">
        <property type="nucleotide sequence ID" value="XM_067207323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GS74"/>
    <dbReference type="GeneID" id="92361257"/>
    <dbReference type="KEGG" id="loi:92361257"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="1">
        <location>
            <begin position="248"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5477984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="423" mass="45733" checksum="EDFFA6F6BA961023" modified="2021-09-29" version="1">MDRSPTYLPPVYSPDATCIHSPVLGDAEVGIASDGRIFEELLDAEVAVNMEKLREASRMGIPPVYRGVVYRYLLGVAFTDKSSEMTMEELQDKDFQLLSTAHTRIWGDGDEDDGRGGAGGGGLVGGHGGGGKVAALHTFRELLKFSTSSTAAANATEGSGPLHCSGGFRGMGSGDAVGGSSGAGTVAMPFVYRGPSAIPALAPSAALAAWEEGVTALRYCAPYNADARQWARMESALAALQMMYCHVSVDNVQLLLLLARQLDRVASSARDTFFTVHALFSMLTQDGNILHDAQTLQTHCGNFLMLFRSVLLPLYEHFTAEGLTTWEWIPSLLTSFFVGRMHPDDVFALWDCYLADMSEHQAMALHPYACLATLSSMTEVLIEAGKTELLYCLEHLPRLDTASIMRKAVLIRESVYSKELLCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GVL9</accession>
    <name>A0A836GVL9_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000019">
        <property type="protein sequence ID" value="KAG5480959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063960.1">
        <property type="nucleotide sequence ID" value="XM_067208448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GVL9"/>
    <dbReference type="SMR" id="A0A836GVL9"/>
    <dbReference type="GeneID" id="92362382"/>
    <dbReference type="KEGG" id="loi:92362382"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5480959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="912" mass="101864" checksum="FB34F18F4B553A7A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GVP7</accession>
    <name>A0A836GVP7_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061151.1">
        <property type="nucleotide sequence ID" value="XM_067204114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GVP7"/>
    <dbReference type="GeneID" id="92358048"/>
    <dbReference type="KEGG" id="loi:92358048"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014903">
        <property type="entry name" value="DUF1796"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08795">
        <property type="entry name" value="DUF1796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5472755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="416" mass="45363" checksum="28492E33B66DD49C" modified="2021-09-29" version="1">MRRWVSLGGWCGPSLMLSKLGLRPAEESLPFDMVRCTFDGLVELTANGFSSSLRLPAPVTSAGPAASLSAAADVAHYSFSAEHEDGYFPQASSASPASSSSDTASTSTSLRFVPDPVKAWLLFRSQHACFTHYDLNNTDVQAELRRRIRAWEALLSPVTKGDADEAGVRPVTFIRTVIAENPAEELEMLPRFHQAVRQRTSGRLPFRTVLVVHDQADTTRPLCAMPQESKDQHPCIVWNLKRQRPTPAPTRSSSSAADATDATSAAAEAPSLLDECHDGYQTILTSMSKNAKWRTLDASLPSYEAYVTSRGAPFAPYTELSRVDGVPAVRGTCTGFGSTFSGVLGRCVHCGCTDGHAVSPAQYDKHRGWQEEDVTELLLNYALHHCDEVAAVEATALRQKRGAHETWQKLRSLLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GXE8</accession>
    <name>A0A836GXE8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_01722</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059460.1">
        <property type="nucleotide sequence ID" value="XM_067203769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GXE8"/>
    <dbReference type="GeneID" id="92357703"/>
    <dbReference type="KEGG" id="loi:92357703"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.210:FF:000017">
        <property type="entry name" value="Zinc finger C-x8-C-x5-C-x3-H type (And similar), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="5">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="5">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5466570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="258" mass="28479" checksum="EDE5ADBA1D3BA1B1" modified="2021-09-29" version="1">MSQQQWTPDQRRQQIAEFLRNKGVICRDFLLSGRCSRSPTCPYMHVANGETRPVPWSVCTFFTQGKCLRDGCSFFHGTQAQLEELHASGAPVYRPQDYMKIAVPPAEYLNPDGSIATHLPISAVPVSPALHMVPGTTMPHENTVNSFHPVLLMQPNSQAIAPAVFASQSCTSHQPSPQFAFYTNAPLPSQITTSSAATVFQPTLHAVQPTAYYQATNVPLAQSQQHFAPIPSFNSPHFQPLQTQPSQGSHVYFHIQPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GYC3</accession>
    <name>A0A836GYC3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small-subunit processome Utp12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_07085</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat PWP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000018">
        <property type="protein sequence ID" value="KAG5481374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064053.1">
        <property type="nucleotide sequence ID" value="XM_067208990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GYC3"/>
    <dbReference type="SMR" id="A0A836GYC3"/>
    <dbReference type="GeneID" id="92362924"/>
    <dbReference type="KEGG" id="loi:92362924"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001291">
        <property type="entry name" value="Periodic tryptophan protein 2-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:003166">
        <property type="entry name" value="Periodic tryptophan protein 2-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027145">
        <property type="entry name" value="PWP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
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    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="402"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="530"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="6">
        <location>
            <begin position="823"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="246"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5481374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="943" mass="103185" checksum="37B07E981236B1B7" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GZQ2</accession>
    <name>A0A836GZQ2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061034.1">
        <property type="nucleotide sequence ID" value="XM_067203997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GZQ2"/>
    <dbReference type="SMR" id="A0A836GZQ2"/>
    <dbReference type="GeneID" id="92357931"/>
    <dbReference type="KEGG" id="loi:92357931"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Putative phosphatase 2C"/>
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        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5472638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="384" mass="41907" checksum="AE01316E8D218036" modified="2021-09-29" version="1">MGLMLPKPILSKVVDRAGNSFVNSACASQNGFRNSMEDAHMLVATEDSDVAYFGIFDGHSNAECSAFVARELPQRLKKLPEPITAEMLEKVCVDVDDAYMKSNVEGGSTGTFCIIRKDLKVTIANVGDSRILVCRGGKLIFATEDHKPYIPGETERIVACGGSVVSNRVDGDLAVSRAFGDASFKVRGVKDYRKQKVIAVPDVSVVQCQPNDFIILACDGVFEGNFSNEDVCRFVWEQQQNCWDDLAVVACRVCDEAIRCGSKDNISCLVVQLAEGASKVKLFGTTSFVPGPPFPRNQQPCRTAYAQMAELGHTTTAAALQTRYQLLQAFSKNKLNAQPPVMRTAFEMSDEVDLETEWSFFGKGPAPGNEKNFFEALANMGNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H056</accession>
    <name>A0A836H056_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Pyruvate/indole-pyruvate carboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LSCM4_01052</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059767.1">
        <property type="nucleotide sequence ID" value="XM_067203117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H056"/>
    <dbReference type="SMR" id="A0A836H056"/>
    <dbReference type="GeneID" id="92357051"/>
    <dbReference type="KEGG" id="loi:92357051"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004737">
        <property type="term" value="F:pyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000949">
        <property type="term" value="P:aromatic amino acid family catabolic process to alcohol via Ehrlich pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02005">
        <property type="entry name" value="TPP_PDC_IPDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07038">
        <property type="entry name" value="TPP_PYR_PDC_IPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000019">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000024">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012110">
        <property type="entry name" value="PDC/IPDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047214">
        <property type="entry name" value="TPP_PDC_IPDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047213">
        <property type="entry name" value="TPP_PYR_PDC_IPDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452:SF30">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE ISOZYME 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036565">
        <property type="entry name" value="Pyruvt_ip_decrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="12">
        <location>
            <begin position="7"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="10">
        <location>
            <begin position="202"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="11">
        <location>
            <begin position="386"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR036565-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
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                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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            <end position="258"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
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        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="487"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="530"/>
            <end position="544"/>
        </location>
    </feature>
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        <location>
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            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="663"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5487576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="741" mass="78375" checksum="431B38292186BBBF" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836H804_9TRYP</name>
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        <name evidence="3" type="ORF">LSCM4_01857</name>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5479265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067204335.1"/>
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    <dbReference type="GeneID" id="92358269"/>
    <dbReference type="KEGG" id="loi:92358269"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="146"/>
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        </location>
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        </location>
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        <location>
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            <end position="459"/>
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        <location>
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        </location>
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        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5472976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="856" mass="95928" checksum="EB6F0522CA0CC1F4" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H9C1</accession>
    <name>A0A836H9C1_9TRYP</name>
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        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="1" type="ORF">LSCM4_04551</name>
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        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Trypanosomatida</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5477333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="221" mass="23965" checksum="73B9BED85B5B490E" modified="2021-09-29" version="1">MAAHLIQPTHPSVAGLAPNVLIISGFPWYTSELAVHRYLTDVYPAAEPVTTRLYTNPTNGASRGHCFVEYNLPPSSAAPSASAVAAAANTFSGTDLRATADDSAVQGSSGDDASDLLLPPILREVKRRVEEQPYECMYLKVHAYILTSQRWSRAGRLPELPTDPPAARWRGRAGVLVGYGDEGFSVRAGRELGLPNTVTPDGQVQLERLRKRLRTASARRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H9D0</accession>
    <name>A0A836H9D0_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061459.1">
        <property type="nucleotide sequence ID" value="XM_067205522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H9D0"/>
    <dbReference type="GeneID" id="92359456"/>
    <dbReference type="KEGG" id="loi:92359456"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="619"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="619"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="631"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5473456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="640" mass="62587" checksum="DE9F29C568E19539" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H9E4</accession>
    <name>A0A836H9E4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribonuclease H</fullName>
            <ecNumber evidence="4">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_07727</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase H family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="4"/>
    <dbReference type="EMBL" id="JAFHLR010000006">
        <property type="protein sequence ID" value="KAG5487239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065736.1">
        <property type="nucleotide sequence ID" value="XM_067209606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H9E4"/>
    <dbReference type="SMR" id="A0A836H9E4"/>
    <dbReference type="GeneID" id="92363540"/>
    <dbReference type="KEGG" id="loi:92363540"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09280">
        <property type="entry name" value="RNase_HI_eukaryote_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.970.10:FF:000001">
        <property type="entry name" value="Ribonuclease H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000202">
        <property type="entry name" value="Ribonuclease H1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.970.10">
        <property type="entry name" value="Ribonuclease H1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_bL9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017067">
        <property type="entry name" value="RNase_H1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011320">
        <property type="entry name" value="RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037056">
        <property type="entry name" value="RNase_H1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF26">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01693">
        <property type="entry name" value="Cauli_VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036852">
        <property type="entry name" value="Ribonuclease_H1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="L9 N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="11">
        <location>
            <begin position="156"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5487239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="380" mass="41344" checksum="3DDA92C48286BBD5" modified="2021-09-29" version="1">MKLSFYAVAVGKARGIYSTWAQCAEQVTGYPGSVYKSFRTLDEARGFLAAHPLPTLGSAVSVGGGSISAASPYPSSRENGAPGSIASKRRLDREMSDDILGEEELAGRQAQRRRADDTHSAAQSLASSSTSTSISAAALSAAAAHPPDTNTATSSSEACEVVYVDGACSHNGTSQARAGYGGYYGSLSDPRNFSCPVPLTESQTNNRGELRAVIHAIVQSFVDAGAPADALEEAHRVDPSAWPLRDLARPLPHLIIYTDSRYVIDGLTRYAKMWVENGFALSTKKPVRNQDLWKQLIRLRDQYNTQYARQQYCQRQRAHQRWDMRNDGAESAEPVRHTCHNTRNDKSEGIELIHVRGHSKVHGNEMADSLAVSGSRRHSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HAT5</accession>
    <name>A0A836HAT5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_08213</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000003">
        <property type="protein sequence ID" value="KAG5487989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066116.1">
        <property type="nucleotide sequence ID" value="XM_067210083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HAT5"/>
    <dbReference type="SMR" id="A0A836HAT5"/>
    <dbReference type="GeneID" id="92364017"/>
    <dbReference type="KEGG" id="loi:92364017"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000104">
        <property type="entry name" value="ATP-binding cassette sub-family F member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002927">
        <property type="entry name" value="Putative ABC transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF117">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="203"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="512"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5487989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="724" mass="82078" checksum="96AFC71CC763E6EE" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HD52</accession>
    <name>A0A836HD52_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">5'a2rel-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
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                <person name="Gatherer D."/>
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                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Bates M.D."/>
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                <person name="Bates M.D."/>
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                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062511.1">
        <property type="nucleotide sequence ID" value="XM_067207208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HGD2"/>
    <dbReference type="GeneID" id="92361142"/>
    <dbReference type="KEGG" id="loi:92361142"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="16"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="401"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5476278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="483" mass="52861" checksum="4F4804C0672C8005" modified="2021-09-29" version="1">MEAVQLAKRVLAADGQPFAILSLAQGFPPVTPETPVPEARRSYMRLAGSIHPDRLQGSFDKATEAFQCLVRAFECFADPKLRKQAAAAARMQVKSKAAPPSTTKAGPSTSRAVKRKREKAKSKPSAAPAVKKPKRAVEIDGEDDELGLSEGDKREEDDDSDASAADGEAWEQWAAAEKEPEVSTNRSPIGQPRVGGLYQPTTVGCPKCRSLWEPDARPQYSLFMGHWGRKVHCQLCLFQFGCATALHGCPHCRAPFDYDASMYDAVQTCQRCKRQFGFPYYPVNQHLIDQIALEEWRERMEREKANAREARARARRGGSSDEASAAEEKRQLLVGTCIMEEECPLCHKRVKSKHRAHVEACLTKTPEGMAALTAKSAKVATRAQRSPDNVFEAPAPRTVQKTPKSAPKAARAAAVKKSSAPPASHANASPRAAGRATKASAPQKRKRRRSDSNSSEEAYFSSECDEDAMTSESSFLGDDDDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HGD4</accession>
    <name>A0A836HGD4_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000010">
        <property type="protein sequence ID" value="KAG5485687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065271.1">
        <property type="nucleotide sequence ID" value="XM_067208560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HGD4"/>
    <dbReference type="GeneID" id="92362494"/>
    <dbReference type="KEGG" id="loi:92362494"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="522"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5485687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="600" mass="63594" checksum="BA3E2FFED9ACB262" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HI37</accession>
    <name>A0A836HI37_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_04350</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">LSCM4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062544.1">
        <property type="nucleotide sequence ID" value="XM_067206335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HI37"/>
    <dbReference type="SMR" id="A0A836HI37"/>
    <dbReference type="GeneID" id="92360269"/>
    <dbReference type="KEGG" id="loi:92360269"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="8">
        <location>
            <begin position="27"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5477133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="120" mass="13478" checksum="A66042E8BBEB8110" modified="2021-09-29" version="1">MHSSLYGNPRPNKVSPSAATRYEPMEEEIHRENEAMLQALGSSVAHMKTIAGHLNREAEEQNELLKSLDRAFQTARGGVHSAVSSVKSVMARYGWRYTAAFGCLGFFLLYFIYAILLRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HIM8</accession>
    <name>A0A836HIM8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BPL/LPL catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_06370</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LplA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000007">
        <property type="protein sequence ID" value="KAG5486902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065696.1">
        <property type="nucleotide sequence ID" value="XM_067208291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HIM8"/>
    <dbReference type="SMR" id="A0A836HIM8"/>
    <dbReference type="GeneID" id="92362225"/>
    <dbReference type="KEGG" id="loi:92362225"/>
    <dbReference type="UniPathway" id="UPA00537">
        <property type="reaction ID" value="UER00595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017118">
        <property type="term" value="F:lipoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16443">
        <property type="entry name" value="LplA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004562">
        <property type="entry name" value="LipoylTrfase_LipoateP_Ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561">
        <property type="entry name" value="LIPOATE-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561:SF3">
        <property type="entry name" value="LIPOYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21948">
        <property type="entry name" value="LplA-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="3">
        <location>
            <begin position="80"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
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        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5486902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="527" mass="57188" checksum="79BC18ED282B7CDB" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HIP8</accession>
    <name>A0A836HIP8_9TRYP</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">LSCM4_07632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
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            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000012">
        <property type="protein sequence ID" value="KAG5484860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064972.1">
        <property type="nucleotide sequence ID" value="XM_067209512.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="loi:92363446"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5484860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="417" mass="44393" checksum="E10EA25D41952669" modified="2021-09-29" version="1">MASIIVAGATGAIGRTVVQMAIRQPSIHHVVALTRSANTAASNYEALFGIFIAGEAGNTDSGGEGSHREKEKRGSVSRDNTVTVTLEEAAKIKPITLDWEEFTQLWVTKRNGASTASSGANNGAAGAASAAMADPMERYRDIFSGHTYAAMCLGTTRKDAGSAKNFIRCDYDYVIAFTEAVLTYSAPAGLSPGTAFVHHIGDEGVSKQAHAQEGMGNELEELVTVNNDAAQSSGTLRAFCQVSSSHANSSSWFLYTKTKGIADESTVERVYHHNNKLTAAAATLTPVNLLLLQPGLLERHGKSRLNEKLAKFIMSSIPVEICGAAIVSACKHSPMHKCVPCAATTSAAEVVKHDEAEEMQAKREDNHATETCKEPLGKPYVATKALRKAGMPCKEPLPHIYEATNSTIKDLASRLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HJG3</accession>
    <name>A0A836HJG3_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000016">
        <property type="protein sequence ID" value="KAG5482433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064439.1">
        <property type="nucleotide sequence ID" value="XM_067207625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HJG3"/>
    <dbReference type="GeneID" id="92361559"/>
    <dbReference type="KEGG" id="loi:92361559"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031298">
        <property type="term" value="C:replication fork protection complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Timeless"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN TIMELESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940">
        <property type="entry name" value="TIMEOUT/TIMELESS-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="702"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="750"/>
            <end position="824"/>
        </location>
    </feature>
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        <location>
            <begin position="1002"/>
            <end position="1036"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1048"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="772"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1010"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1066"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1098"/>
            <end position="1115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5482433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1146" mass="126368" checksum="53F6F400FA2CD41B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HJM3</accession>
    <name>A0A836HJM3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_05428</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histone deacetylase family. HD type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2"/>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5478030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062937.1">
        <property type="nucleotide sequence ID" value="XM_067207369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HJM3"/>
    <dbReference type="SMR" id="A0A836HJM3"/>
    <dbReference type="GeneID" id="92361303"/>
    <dbReference type="KEGG" id="loi:92361303"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09991">
        <property type="entry name" value="HDAC_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000029">
        <property type="entry name" value="Putative histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF10">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="6">
        <location>
            <begin position="102"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="42"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="499"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="519"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5478030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="536" mass="57922" checksum="135F47F7DF237D2B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HK46</accession>
    <name>A0A836HK46_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DNA 5'-3' helicase</fullName>
            <ecNumber evidence="17">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">LSCM4_05523</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the helicase family. RAD3/XPD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="17"/>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5478123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063030.1">
        <property type="nucleotide sequence ID" value="XM_067207462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HK46"/>
    <dbReference type="SMR" id="A0A836HK46"/>
    <dbReference type="GeneID" id="92361396"/>
    <dbReference type="KEGG" id="loi:92361396"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045951">
        <property type="term" value="P:positive regulation of mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002281">
        <property type="entry name" value="DNA repair helicase rad3/xp-D, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002858">
        <property type="entry name" value="DNA repair helicase rad3/xp-D, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000128">
        <property type="entry name" value="Putative DNA repair helicase RAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010643">
        <property type="entry name" value="HBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001945">
        <property type="entry name" value="RAD3/XPD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06777">
        <property type="entry name" value="HBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00852">
        <property type="entry name" value="XRODRMPGMNTD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="21">
        <location>
            <begin position="7"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="769"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="246"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAG5478123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="813" mass="91718" checksum="87F49F4722AAF939" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HKK0</accession>
    <name>A0A836HKK0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_04758</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000023">
        <property type="protein sequence ID" value="KAG5478525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063186.1">
        <property type="nucleotide sequence ID" value="XM_067206739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HKK0"/>
    <dbReference type="SMR" id="A0A836HKK0"/>
    <dbReference type="GeneID" id="92360673"/>
    <dbReference type="KEGG" id="loi:92360673"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027328">
        <property type="entry name" value="MAPRE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10623">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN RP/EB FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="213"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="260"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="323"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5478525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="443" mass="49096" checksum="80B6B477433598D7" modified="2021-09-29" version="1">MPARSAVLSGRKELLQWLNNLCDADYPAVESLRDGAAYCTIVEAAVSRIAQNCAATQSSEASVTKSRADQARTYLAKLDWSATAPVCENVDPSLDSVSIREICFHNMRLLQNILQECVPPEHRSTVEADRLAAGKLQDHVVLLRWLYLFMSKVLAQYSKKALEKKAGVVAGTVEGVKLNRTVRLRSRQASGSDCREVHVLTQPREKKIDMIGEENNTTPRRLHADPALSRTSPRKRTHHDRVEAVRDSDSLFRTLIEYNGGPTLADASPRGGLPDADTRTGKPSPRATSAAGPSKGHMSASAEEVLRERTVHAHYTRGTIAVPEAFRATLVRLRNEVEELERQVLFAQERHNYYLTHRASEGEAGRVLSVVAAKYGQDARICEEVRETFSLEELGELLEERDRLAQQYAAVDAVVTRSLESARSQGKTIAPLLHDLVELLHPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HKM9</accession>
    <name>A0A836HKM9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_07309</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000015">
        <property type="protein sequence ID" value="KAG5483093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064589.1">
        <property type="nucleotide sequence ID" value="XM_067209206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HKM9"/>
    <dbReference type="GeneID" id="92363140"/>
    <dbReference type="KEGG" id="loi:92363140"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5483093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="32834" checksum="5BD33A0B7E3B2E4E" modified="2021-09-29" version="1">MKPWWTANLFTPAEVQRAFAALLQSAEMLYGVSRTSTLLSPFVHRRGSAGGYRRDHIELPLHHMYKSDAVYQQLPVELRLLCTGLHQAALYYAQEALRETCVSSVARNGILDNLGRKSVLRVLRYPAGSGCRPHVDPGLCTALLVGSAGGLEVSTTGPVSIPFANRPGDYTEHMASSPARMRCEESSISRTLPHWEPLLTAHAGEAVVMAGNMLGAISGGALPGVRHRVRQDWASNIPRRDGQRSLFDDAASIASGIDAGASDGSAGFRFNVIVELRPAEAKRWYAAASRQQPLSFVSSSPSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HME0</accession>
    <name>A0A836HME0_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000022">
        <property type="protein sequence ID" value="KAG5479278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063371.1">
        <property type="nucleotide sequence ID" value="XM_067203912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HME0"/>
    <dbReference type="GeneID" id="92357846"/>
    <dbReference type="KEGG" id="loi:92357846"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="765"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="765"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5479278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1083" mass="112037" checksum="5590C12090C4D8E7" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HMX9</accession>
    <name>A0A836HMX9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glycerol uptake protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_06512</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000019">
        <property type="protein sequence ID" value="KAG5480941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063942.1">
        <property type="nucleotide sequence ID" value="XM_067208430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HMX9"/>
    <dbReference type="GeneID" id="92362364"/>
    <dbReference type="KEGG" id="loi:92362364"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051085">
        <property type="entry name" value="MB_O-acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285:SF18">
        <property type="entry name" value="PROTEIN-CYSTEINE N-PALMITOYLTRANSFERASE RASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="548"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="621"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="643"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="684"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="723"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5480941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="761" mass="84039" checksum="5DA4C87A7F8F0F55" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HNE6</accession>
    <name>A0A836HNE6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NTF2-related export protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_07825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000006">
        <property type="protein sequence ID" value="KAG5487335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065832.1">
        <property type="nucleotide sequence ID" value="XM_067209702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HNE6"/>
    <dbReference type="SMR" id="A0A836HNE6"/>
    <dbReference type="GeneID" id="92363636"/>
    <dbReference type="KEGG" id="loi:92363636"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000020">
        <property type="entry name" value="Nuclear transport factor 2 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045875">
        <property type="entry name" value="NTF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12612">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NTF2" evidence="2">
        <location>
            <begin position="13"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU369002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5487335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="136" mass="16150" checksum="25310E5ECFDB850E" modified="2021-09-29" version="1">MMEQGAFNDVAKKALEFRSRYYKMLDDPQDRSNVAGLYAPDVPMVCEWNGHPLSTVDDVRNYISALPKTSHQIDMVDAQPLPDNQDGDSFLLTVHGTVTYNDEHRREFYQRMIIRRFEQRYYILSDYYRWLSERSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HQ35</accession>
    <name>A0A836HQ35_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Enkurin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_06433</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000019">
        <property type="protein sequence ID" value="KAG5480865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063866.1">
        <property type="nucleotide sequence ID" value="XM_067208354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HQ35"/>
    <dbReference type="SMR" id="A0A836HQ35"/>
    <dbReference type="GeneID" id="92362288"/>
    <dbReference type="KEGG" id="loi:92362288"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="214"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="160"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5480865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="32376" checksum="45D1B05E79DA8E06" modified="2021-09-29" version="1">MEEAINVFGRGTPAGEAIYRCYIAPSKPSTLDPQLAALLARRRHEREAAEAAQVHPKPIPKSKAPVHRPRVGLGRRPTEEEYARWRLHQIPHRRSKAAIEAVEEARSGVPHPVSDRFARPAITESEKDRLADVMAYGSELPKPKELTGAQRVRLHRLNPHAELEDRFAKLRQTAQEVQRELAQLRQSSLGVGASSPSGVVETGGVSDAQTRLSERCSHGDGSNSGTASPHPLASTASPGAAAACGGLGIGGIRVGRYGESSVSKVKRCQRERELQSHLSTVIAEMEGVDRELSRLAISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HQF9</accession>
    <name>A0A836HQF9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_06391</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000019">
        <property type="protein sequence ID" value="KAG5480823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063824.1">
        <property type="nucleotide sequence ID" value="XM_067208312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HQF9"/>
    <dbReference type="GeneID" id="92362246"/>
    <dbReference type="KEGG" id="loi:92362246"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5480823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="402" mass="46661" checksum="E6BB4604B1F5D971" modified="2021-09-29" version="1">MKPKAAQVRQQQSLNRRAKLEESAARAQQNLFARQGLMRDAVGAYQRNPMYGYAGYPARNRDPNRGVITQTEWNELVERHEDSGKCFRYLFGILIFAAIFFLTLTKYDEEYNLEVPQVESGRGFGEVLNPQRAVDAEELEAYYHTLGVEGRLNLTARTTSGVNTASEANRSSKKATDDPDKARRRENYKVRQQIKQAFHDHQEKYGQLVYCGRRCEAENKQVEFAYNKLTSQVDRELFGVLLDAKDTKSVRSTTPAQLKRKYEEKRRQILETEEDEEDRKMALEELKDAYDIIENPDARTYYLLYGAKPPEQMRHVSARHGGWGQEMALGTFKHRIIIMWLDFLHQYIGVWGETAVLGCVLLFALLRLPQAMKDSERFLQELDLDEHTEEENRTVEQADQKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HQN5</accession>
    <name>A0A836HQN5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_06452</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000019">
        <property type="protein sequence ID" value="KAG5480883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063884.1">
        <property type="nucleotide sequence ID" value="XM_067208372.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836HQN5"/>
    <dbReference type="GeneID" id="92362306"/>
    <dbReference type="KEGG" id="loi:92362306"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000135">
        <property type="entry name" value="Putative kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="6">
        <location>
            <begin position="30"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="235"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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                <person name="Bates M.D."/>
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                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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                <person name="Bates M.D."/>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="475"/>
            <end position="507"/>
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            <end position="1002"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="915"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="948"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="985"/>
            <end position="996"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5466459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1108" mass="118680" checksum="4EF200304932747F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836K904</accession>
    <name>A0A836K904_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_00798</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067202871.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="92356805"/>
    <dbReference type="KEGG" id="loi:92356805"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033049778" evidence="2">
        <location>
            <begin position="22"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5467719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="569" mass="62053" checksum="9BE7453EF084EA69" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836K975</accession>
    <name>A0A836K975_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cilia- and flagella-associated protein 418</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_01030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">May be involved in photoreceptor outer segment disk morphogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Photoreceptor inner segment</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059746.1">
        <property type="nucleotide sequence ID" value="XM_067203096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836K975"/>
    <dbReference type="GeneID" id="92357030"/>
    <dbReference type="KEGG" id="loi:92357030"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029239">
        <property type="entry name" value="CFAP418"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33958:SF1">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33958">
        <property type="entry name" value="PROTEIN C8ORF37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
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        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
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        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00024819"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00026215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5467944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="350" mass="38162" checksum="6DBBB201DA848D68" modified="2021-09-29" version="1">MSELDSLIEELFPEEKNNGCISVAASGPSHRPSEWDDESGNDEDIGKATDANLRTSLERHTSTAPSPVQPTVSATREGPTRGSMAHCFDDDSDADGNAERGVVHRQESREQARSEPDARSFIGVSKPVLFPVPFPSLSDSEGSYACASRCYLTNLGTPLSSDGGHPTLRQLRAIAADEKANVEPSRIQAMLLKGAFHAAIAKLGNGCLDHHGDDTGDGGCPHILCRHCNYMVVRLQNAEWDAEGEVNLYLTLRNFYPDWCRLASATPVGVENGPEALRYVLRTSLSAAAYCCQCSWVTVRSAKAVIETRLTDLTMVRPAREGEHLFATELPLLPGEIRRPPLWVCHGHTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836K9D6</accession>
    <name>A0A836K9D6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Alternative oxidase</fullName>
            <ecNumber evidence="12">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LSCM4_00472</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="12">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the alternative oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="12"/>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058652.1">
        <property type="nucleotide sequence ID" value="XM_067202551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836K9D6"/>
    <dbReference type="GeneID" id="92356485"/>
    <dbReference type="KEGG" id="loi:92356485"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098803">
        <property type="term" value="C:respiratory chain complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009916">
        <property type="term" value="F:alternative oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010230">
        <property type="term" value="P:alternative respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.140">
        <property type="entry name" value="Alternative oxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002680">
        <property type="entry name" value="AOX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038659">
        <property type="entry name" value="AOX_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31803">
        <property type="entry name" value="ALTERNATIVE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31803:SF33">
        <property type="entry name" value="ALTERNATIVE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01786">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG5465021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="476" mass="51773" checksum="A739712A38A1318D" modified="2021-09-29" version="1">MLQSHIRVASASVSCTRRDASHSTGRHGAHQCASRTTSSARFSGNRSVKSSNACATSARIKPPSYLYRSFMGHSTRFAAMKPPLTRAGITQLEREPLTHSTPGRINDHICIFMVKTLRWLADRAFRERYIHRATMLVTVAAAAPAAGSVAGYLRMLLRRRSSGITCAGGAKTPITAEASSPFLALGKPKSADTAPSAPGACRSFATARLSLRTSAGSAAMEGTRAALEHPYVDELRGLLAQCESHTIHYQVLSSMADITPAERALVLLLQALHFTVYLVLFLFYPRMGFRLMAYTAEESSVVWTQMVNDYDLGKIVERPVPQLAMHYWGLDDVFTAQAPLVPMAAASQKQEMVLYKPSKRCVTERIPVANALYSADAGSQGATSPLSAFDCASGPTTASAPLDDRAVEATENEGRAIPSSELETGSSAYVLTLRDVALLIRSDEMVFRDLNHEWADELDTQPSWLRCLVRSRGAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KA60</accession>
    <name>A0A836KA60_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_02342</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5468949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059926.1">
        <property type="nucleotide sequence ID" value="XM_067204374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KA60"/>
    <dbReference type="SMR" id="A0A836KA60"/>
    <dbReference type="GeneID" id="92358308"/>
    <dbReference type="KEGG" id="loi:92358308"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002329">
        <property type="entry name" value="ATP-binding cassette protein subfamily F, member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003120">
        <property type="entry name" value="ATP-binding cassette protein subfamily F, member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF14">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="69"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="386"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="632"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="633"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5468949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="668" mass="74761" checksum="0ABB729E4A5758DF" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KA91</accession>
    <name>A0A836KA91_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060001.1">
        <property type="nucleotide sequence ID" value="XM_067204449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KA91"/>
    <dbReference type="SMR" id="A0A836KA91"/>
    <dbReference type="GeneID" id="92358383"/>
    <dbReference type="KEGG" id="loi:92358383"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5469024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="450" mass="48794" checksum="FF2200D8E8010604" modified="2021-09-29" version="1">MDGSDPAFYEDAVLPLDDEVKEDTPQATLKLIGDFPEPLTEPQRRTFQRHVSQKVREYEAVRYQVAVVEQGYLALLRLVKRLRQEVQDLSATLAEGGCKSEASVPTAAATLTTAGATPSAAPAATEKPSAVIATADTPVASPTKEGAVAPKRRPGGLLVRSSVFNSLQRVLQAAKTEQLNEKAEQLARQRERIARESRFHLVSRDLEAQEALLGPLQRKYARAVALGTAAAEEVTPLLTLLEDMWRLEVLYPSRFSMVAKGAPQPFLGDSAHADGEGNRAEEELVVDGTGNATGGPTAQSAATVPYMVPFTPAHYTAHVEDLIRAQVEEVIDEYLAYRTRMDPVLYQLEQSQQLAEAKKVNQLMDVIGIAGAETGTEVLPIGGAAVVLRGERTGVWTKRPQHMMDISSEEEDDDQAGAGVTPGGDVADVDHYDREQIRTALTALDDFEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KBK2</accession>
    <name>A0A836KBK2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_01382</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059127.1">
        <property type="nucleotide sequence ID" value="XM_067203436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KBK2"/>
    <dbReference type="GeneID" id="92357370"/>
    <dbReference type="KEGG" id="loi:92357370"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050670">
        <property type="entry name" value="STAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929:SF3">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="56"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="161"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="278"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="240"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5466237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="489" mass="53115" checksum="19D65E30128560AD" modified="2021-09-29" version="1">MDSLWRLRREERQKIRQSGADASGFVEAVSRFAVDDDSTICSDESCAKHDGAASELNTEQCIALIDYVAFDDDEISFRAGDVINVTRKGAASGFWEGYVVTPTSPVLATAEYSDADHIGSLSRFPAGPLPPPHTHRLRRRGLFPNCFVTSNMRLKSLSQCAFQNAALCLYAYEATGDGEMSFVAGDVITAVRPSSSPGWWYGVKSSGPAWAAPRTAKGSSSPAVTSTRFADPMAVTDSSASCAETEEETAVNTAPQRTTGTPSGHGRDKERLFPTNFVTCDIVQANFTFTGRHPHELSFKAGDIIQVHRRWNDGWWEGSLRGRRGIFPSNYTIPNITTTALPLFCARCRTILGSSMFRSTCATCAAEERVEDAMMQALEAYVRGEATELDLFAGVDIGLRTASETCSAGDSDGGVDRASGQSSCKVSHGKLRDWTRGFNDISASARCNRRISCQHQRRHGGGAPCEARVPLLTEKDIADLASNRVKLME</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KBN8</accession>
    <name>A0A836KBN8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_01507</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059247.1">
        <property type="nucleotide sequence ID" value="XM_067203556.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836KBN8"/>
    <dbReference type="GeneID" id="92357490"/>
    <dbReference type="KEGG" id="loi:92357490"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF56">
        <property type="entry name" value="MAPKK KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-0418">Kinase</keyword>
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    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
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            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="474"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="518"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
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            <end position="1450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5466357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1869" mass="201651" checksum="740CEA97A8A238E9" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KBR0</accession>
    <name>A0A836KBR0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Piezo non-specific cation channel R-Ras-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_00895</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059613.1">
        <property type="nucleotide sequence ID" value="XM_067202963.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92356897"/>
    <dbReference type="KEGG" id="loi:92356897"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071260">
        <property type="term" value="P:cellular response to mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050982">
        <property type="term" value="P:detection of mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027272">
        <property type="entry name" value="Piezo"/>
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        <property type="entry name" value="Piezo_cap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056770">
        <property type="entry name" value="Piezo_THU9_anchor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13167">
        <property type="entry name" value="PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13167:SF25">
        <property type="entry name" value="PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12166">
        <property type="entry name" value="Piezo_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24874">
        <property type="entry name" value="Piezo_THU9_anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="234"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
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    <feature type="transmembrane region" description="Helical" evidence="2">
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    <feature type="transmembrane region" description="Helical" evidence="2">
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        <location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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        <location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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        </location>
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        <location>
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    </feature>
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        <location>
            <begin position="1236"/>
            <end position="1482"/>
        </location>
    </feature>
    <feature type="domain" description="Piezo non-specific cation channel cap" evidence="3">
        <location>
            <begin position="1537"/>
            <end position="1848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="1207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="1730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1183"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1714"/>
            <end position="1725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12166"/>
        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF24874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1879" mass="205689" checksum="C8F9890736694085" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KBR8</accession>
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        <name type="scientific">Leishmania orientalis</name>
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    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="protein sequence ID" value="KAG5465020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067202550.1"/>
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        <property type="term" value="F:ubiquitin protein ligase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:protein polyubiquitination"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
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    </dbReference>
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        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
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    </dbReference>
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        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
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    </dbReference>
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        <property type="entry name" value="HECT_dom"/>
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    </dbReference>
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        <property type="entry name" value="HECTD1/TRIP12-like"/>
    </dbReference>
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        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670:SF14">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIP12"/>
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    </dbReference>
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        <property type="entry name" value="HECTc"/>
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        </location>
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        </source>
    </evidence>
    <sequence length="2569" mass="275702" checksum="32F9F2F98A097CEF" modified="2021-09-29" version="1"> </sequence>
</entry>
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    <accession>A0A836KD53</accession>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
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            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KE03</accession>
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        <name evidence="2" type="ORF">LSCM4_02143</name>
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            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
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                <person name="Al-Salem W.S."/>
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            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5472819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
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</entry>
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    <name>A0A836KFJ3_9TRYP</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5468935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059912.1">
        <property type="nucleotide sequence ID" value="XM_067204360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KFJ3"/>
    <dbReference type="GeneID" id="92358294"/>
    <dbReference type="KEGG" id="loi:92358294"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5468935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="563" mass="61750" checksum="C5E0B2B3BD0E333B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KFR3</accession>
    <name>A0A836KFR3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Heat shock protein 70</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_03732</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
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                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="1 5">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061665.1">
        <property type="nucleotide sequence ID" value="XM_067205728.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="92359662"/>
    <dbReference type="KEGG" id="loi:92359662"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000545">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000055">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
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            <end position="527"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5474559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="527" mass="57165" checksum="625E288AF50CF7B8" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KFT0</accession>
    <name>A0A836KFT0_9TRYP</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060152.1">
        <property type="nucleotide sequence ID" value="XM_067204600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KFT0"/>
    <dbReference type="GeneID" id="92358534"/>
    <dbReference type="KEGG" id="loi:92358534"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="983"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1022"/>
            <end position="1042"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5469175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1050" mass="114316" checksum="31BB2F4E4CC63614" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KGD9</accession>
    <name>A0A836KGD9_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Kinetoplastea</taxon>
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            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060889.1">
        <property type="nucleotide sequence ID" value="XM_067205337.1"/>
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    <dbReference type="SMR" id="A0A836KGD9"/>
    <dbReference type="GeneID" id="92359271"/>
    <dbReference type="KEGG" id="loi:92359271"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="570"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="655"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="799"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="587"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="655"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5471772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="834" mass="90098" checksum="34F670B5116EBED8" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KJZ4</accession>
    <name>A0A836KJZ4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="30">Dynein heavy chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">LSCM4_04782</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="29" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="28">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000023">
        <property type="protein sequence ID" value="KAG5478549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063210.1">
        <property type="nucleotide sequence ID" value="XM_067206763.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836KJZ4"/>
    <dbReference type="GeneID" id="92360697"/>
    <dbReference type="KEGG" id="loi:92360697"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000153">
        <property type="entry name" value="Dynein axonemal heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1220:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002141">
        <property type="entry name" value="Dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000001">
        <property type="entry name" value="dynein heavy chain 17, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000001">
        <property type="entry name" value="dynein heavy chain 2, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.20:FF:000009">
        <property type="entry name" value="Dynein heavy chain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000044">
        <property type="entry name" value="Dynein heavy chain 5, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.30:FF:000009">
        <property type="entry name" value="Dynein heavy chain 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.280:FF:000022">
        <property type="entry name" value="Dynein heavy chain, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.130:FF:000003">
        <property type="entry name" value="Dynein, axonemal, heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000049">
        <property type="entry name" value="Dynein, axonemal, heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000016">
        <property type="entry name" value="Putative dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1120:FF:000028">
        <property type="entry name" value="Putative dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002138">
        <property type="entry name" value="Putative dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056759">
        <property type="entry name" value="DYH2-5-8_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054354">
        <property type="entry name" value="DYNC2H1-like_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013594">
        <property type="entry name" value="Dynein_heavy_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703">
        <property type="entry name" value="DYNEIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703:SF32">
        <property type="entry name" value="DYNEINS HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08385">
        <property type="entry name" value="DHC_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25007">
        <property type="entry name" value="DYH2-5-8_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22597">
        <property type="entry name" value="DYN_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="9 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Dynein heavy chain tail" evidence="17">
        <location>
            <begin position="276"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein axonemal heavy chain 2/5/8 coiled-coil" evidence="27">
        <location>
            <begin position="1263"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain linker" evidence="18">
        <location>
            <begin position="1452"/>
            <end position="1853"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain hydrolytic ATP-binding dynein motor region" evidence="19">
        <location>
            <begin position="2038"/>
            <end position="2364"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA 5 extension" evidence="23">
        <location>
            <begin position="2540"/>
            <end position="2666"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein 2 heavy chain 1 cytoplasmic ATPase lid" evidence="26">
        <location>
            <begin position="2868"/>
            <end position="2954"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA module D4" evidence="21">
        <location>
            <begin position="3041"/>
            <end position="3303"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain coiled coil stalk" evidence="20">
        <location>
            <begin position="3317"/>
            <end position="3649"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain ATP-binding dynein motor region" evidence="22">
        <location>
            <begin position="3677"/>
            <end position="3898"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain region D6 P-loop" evidence="16">
        <location>
            <begin position="4150"/>
            <end position="4261"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA lid" evidence="24">
        <location>
            <begin position="4296"/>
            <end position="4440"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain C-terminal" evidence="25">
        <location>
            <begin position="4447"/>
            <end position="4757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="3532"/>
            <end position="3602"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="3846"/>
            <end position="3873"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF03028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF08393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF12774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF12777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF12780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF12781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF17852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF18198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF18199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF22597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF25007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="KAG5478549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="30">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="4761" mass="545304" checksum="1586127BB1B470DA" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KK20</accession>
    <name>A0A836KK20_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LSCM4_03548</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_067205546.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836KK20"/>
    <dbReference type="GeneID" id="92359480"/>
    <dbReference type="KEGG" id="loi:92359480"/>
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        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="C:microtubule associated complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Kinesin family member 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF15">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="12">
        <location>
            <begin position="91"/>
            <end position="444"/>
        </location>
    </feature>
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            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
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            <end position="1315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
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            <begin position="943"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1144"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1465"/>
            <end position="1527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
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            <begin position="10"/>
            <end position="23"/>
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            <end position="80"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
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            <begin position="793"/>
            <end position="805"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
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            <end position="1576"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="182"/>
            <end position="189"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG5473480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1731" mass="198874" checksum="448E97B6D41B1550" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KK34</accession>
    <name>A0A836KK34_9TRYP</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneID" id="92359510"/>
    <dbReference type="KEGG" id="loi:92359510"/>
    <dbReference type="Proteomes" id="UP000674143">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <end position="79"/>
        </location>
    </feature>
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        </location>
    </feature>
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    </feature>
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        <location>
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            <end position="1682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1686"/>
            <end position="1698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1702"/>
            <end position="1717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5473510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1948" mass="203888" checksum="8BB7ACF313B7B695" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KK53</accession>
    <name>A0A836KK53_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_03639</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061573.1">
        <property type="nucleotide sequence ID" value="XM_067205636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KK53"/>
    <dbReference type="GeneID" id="92359570"/>
    <dbReference type="KEGG" id="loi:92359570"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030865">
        <property type="term" value="P:cortical cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035303">
        <property type="term" value="P:regulation of dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039865">
        <property type="entry name" value="PPP2R3C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12085">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B'' SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12085:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B'' SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="172"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="195"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="207"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5473570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="620" mass="69964" checksum="814452383867EAEE" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KK66</accession>
    <name>A0A836KK66_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LSCM4_03685</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061618.1">
        <property type="nucleotide sequence ID" value="XM_067205681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KK66"/>
    <dbReference type="GeneID" id="92359615"/>
    <dbReference type="KEGG" id="loi:92359615"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07991">
        <property type="entry name" value="LPLAT_LPCAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045252">
        <property type="entry name" value="LPCAT1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063">
        <property type="entry name" value="PHOSPHOLIPID ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063:SF58">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="14">
        <location>
            <begin position="212"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG5473615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="415" mass="47091" checksum="9B6B86B76510FCF0" modified="2021-09-29" version="1">MAQRKMGDETWVATPYMVHGAAEQYLRIPCAACIWYVFLCGVLAPFLRSADDAAPATPCCSLWLLLTWSRAYLCANGLFLVTFFLVENIRFLIAPGPRRLSLADDYEEGDPPKVDKMVALEYDTPADTYERVKMFFFMVTGVAFVRAFTALTSIFLGLFTAGVAGYLDRYAYPWWFGFWSRVATFISIVTFSVLGVHNVQQYGRFATRSECKILIANHSCVMEVVWFYVMGGFPSFVSRKENLSFAFFGNVVRASSSILVDRDVATSREQAMATIQQRAGDPAAPQLMIFPEGTTGNQQALFMFKKGVFETALPVQMVCITFPYKHFNPAWTGRGTGGNSLWDILLRLSCQFVNYAEVRLLPVYHPTEEEKKDPKLYASHCQRMMATVLREKISDASFRDYKEASLYFTELRKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KK69</accession>
    <name>A0A836KK69_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HORMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_04524</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">LSCM4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062717.1">
        <property type="nucleotide sequence ID" value="XM_067206508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KK69"/>
    <dbReference type="SMR" id="A0A836KK69"/>
    <dbReference type="GeneID" id="92360442"/>
    <dbReference type="KEGG" id="loi:92360442"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5485392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1017" mass="107885" checksum="DD3B724BEE579F78" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KUT6</accession>
    <name>A0A836KUT6_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_07435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000008">
        <property type="protein sequence ID" value="KAG5486502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065568.1">
        <property type="nucleotide sequence ID" value="XM_067209325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KUT6"/>
    <dbReference type="GeneID" id="92363259"/>
    <dbReference type="KEGG" id="loi:92363259"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5486502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="397" mass="42866" checksum="42910A610622023A" modified="2021-09-29" version="1">MESRMGSLVLRRDLSLEVPKLLVGAVQPYQTLAGPALTTTFLRHPDLLPFQRAAFSDAAVAPLYFHTLLHTLAEFAETPRAVPYSAVKLRHAPKANFWDSVGTLNCFYYSAYSSHGAPTAASASDEHPAMGAVELVRPGHRQECDVKLTLFDNAHQPIASMLMTGPPCAAREAGDDAVESTRGPTSTCPHARRAFPYVAPPNEETMCAGTCDSAVVIGGTQVCGGLYGDLMPMESGGGFGQRACYTVKDVAASSLAPDAPNHISEAPTDDEHAPSSLARTVMPPWVLYDCVQRFFLRLHSSGAFGAEAGIVPAEGWRACAHHVIQTDDAVFGVPVEVVCALPRVYSSYRLQPWRHQLGLPAISSAVPCVCLRCETRQGGRLVSTGVYYFCRWCIKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KVK2</accession>
    <name>A0A836KVK2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cysteamine dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_07832</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000006">
        <property type="protein sequence ID" value="KAG5487342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065839.1">
        <property type="nucleotide sequence ID" value="XM_067209709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KVK2"/>
    <dbReference type="SMR" id="A0A836KVK2"/>
    <dbReference type="GeneID" id="92363643"/>
    <dbReference type="KEGG" id="loi:92363643"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20289">
        <property type="entry name" value="cupin_ADO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012864">
        <property type="entry name" value="PCO/ADO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22966">
        <property type="entry name" value="2-AMINOETHANETHIOL DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22966:SF61">
        <property type="entry name" value="2-AMINOETHANETHIOL DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07847">
        <property type="entry name" value="PCO_ADO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5487342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="269" mass="29066" checksum="EF76CB672F05D89D" modified="2021-09-29" version="1">MQRLIKSLQHFSATSSEHVELLSKLTLRDFGVYVSDADAKRYMASEAYPIAEHTFQLENALHQRRLCDRSAQVFPMAWKSSSTDILGCSTLYQNETVTLCWFVIPPGKALPLHDHPGMTVWQRAMHGRLHLCSIVRGASAQAGTGASIAPNVGTVIFDGELEGVGDAIAASEVLGFTPAGGGVLHEIRNIDAAQPAFFVDIISPPYNQAPSNIQCSYYTAEPLDATATLLPSFGADSGVRHQLKAGDKVGLHPRSNYSGPAMDAFVRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KW92</accession>
    <name>A0A836KW92_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_08287</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000003">
        <property type="protein sequence ID" value="KAG5488062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066189.1">
        <property type="nucleotide sequence ID" value="XM_067210156.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92364090"/>
    <dbReference type="KEGG" id="loi:92364090"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="77"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="751"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1028"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="771"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5488062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1984" mass="210923" checksum="121C5791251C8BEB" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KY93</accession>
    <name>A0A836KY93_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_05619</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HesB/IscA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000016">
        <property type="protein sequence ID" value="KAG5482363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064369.1">
        <property type="nucleotide sequence ID" value="XM_067207555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KY93"/>
    <dbReference type="SMR" id="A0A836KY93"/>
    <dbReference type="GeneID" id="92361489"/>
    <dbReference type="KEGG" id="loi:92361489"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.300.12:FF:000019">
        <property type="entry name" value="Iron-sulfur assembly protein 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="ATAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="ATAP_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050322">
        <property type="entry name" value="Fe-S_cluster_asmbl/transfer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017870">
        <property type="entry name" value="FeS_cluster_insertion_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00049">
        <property type="entry name" value="iron-sulfur cluster assembly accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10072:SF41">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 1 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10072">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01152">
        <property type="entry name" value="HESB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core" evidence="3">
        <location>
            <begin position="199"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="77"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5482363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="305" mass="32461" checksum="E33822EECD133637" modified="2021-09-29" version="1">MQRRLCSVGGSRMQTSLFGRIGGAALCQQRPLQSTAAADSGTTAAAAVNSSRYSEFRENVSLPSGTPLPTQQVYKSFHKGRGTTPMPKPCQQRNVRARYTPASASDASLPATAGAAAGPSPLLGARSSCAEDTGPVPQRALSPLQKRQLQLRNKAAFVLTPQALQRVKYLLAQYSAAHSAAAAKSPLASDATSEVPSGIRIGVRRRGCSGYSYTVNYYFDTAEASGKDTAPSRKMGGLLEDLAVEQDGVKVVVDADAQFYVIGTEMDYVVGSVEEKFTFKNPNQKYSCGCGESFMPFDADDMDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KYJ2</accession>
    <name>A0A836KYJ2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_08115</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">LSCM4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000005">
        <property type="protein sequence ID" value="KAG5487670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065958.1">
        <property type="nucleotide sequence ID" value="XM_067209991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KYJ2"/>
    <dbReference type="SMR" id="A0A836KYJ2"/>
    <dbReference type="GeneID" id="92363925"/>
    <dbReference type="KEGG" id="loi:92363925"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000363">
        <property type="entry name" value="Methyltransferase domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051419">
        <property type="entry name" value="Lys/N-term_MeTrsfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176:SF74">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="4">
        <location>
            <begin position="43"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5487670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="245" mass="28236" checksum="014449348BA3F78A" modified="2021-09-29" version="1">MSKYANPEYWEDRYRSNDTTFDWFVTYDNLQAILRPLLQPAEQIRVLVVGCGNSRLSANMYEHLNIKKITNVDVSPTVISQMQRRYSEMNEMQWICVDLLTTPIEKLMLELCPNDYLYDFIVDKGLVDSILGGANSFHNLYTYNKNMSRLLKRGGRFIVVSYGSPETRMDHFRRKKLNFDVEHKLLEKPMLSSSTASPTGHYHVYIMLKVGAKTGTGASVSAGGVESEEDDDFYDRFMTQNYATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836L0E2</accession>
    <name>A0A836L0E2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Chaperonin TCP20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_08000</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">LSCM4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000013">
        <property type="protein sequence ID" value="KAG5484433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064926.1">
        <property type="nucleotide sequence ID" value="XM_067209876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836L0E2"/>
    <dbReference type="SMR" id="A0A836L0E2"/>
    <dbReference type="GeneID" id="92363810"/>
    <dbReference type="KEGG" id="loi:92363810"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03342">
        <property type="entry name" value="TCP1_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000058">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000004">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012722">
        <property type="entry name" value="Chap_CCT_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02347">
        <property type="entry name" value="chap_CCT_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0346">Stress response</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5484433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="538" mass="58634" checksum="B54C9F90E51C3E4F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FL43</accession>
    <name>A0A836FL43_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_00047</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058238.1">
        <property type="nucleotide sequence ID" value="XM_067202137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836FL43"/>
    <dbReference type="SMR" id="A0A836FL43"/>
    <dbReference type="GeneID" id="92356071"/>
    <dbReference type="KEGG" id="loi:92356071"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000144">
        <property type="entry name" value="TPR-repeat-containing chaperone protein DNAJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000726">
        <property type="entry name" value="TPR-repeat-containing chaperone protein DNAJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052758">
        <property type="entry name" value="SRC_co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44200">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44200:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="17"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="51"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="254"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="4">
        <location>
            <begin position="377"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="439"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="332"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5464607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="510" mass="56260" checksum="95D10D12B1145765" modified="2021-09-29" version="1">MTQDEVSAASSSVRGNWEALKEQGNHAFKSNAFAEAIQHYSAAIEAHPDEPVLYSNRSAAYLKRGQYQEAANDAEKAVAMDSTFAKAYSRLHSALCNLGLFDRAAEALKAGLIAVSTSPKATPQDVKHLRELVSSAEQAGKVVPRGRQLIEAGFFAEAGRALAGLYREFPGFPTLAFLYAEAHASSSPDEASKALSPFAYTHNSDPYYLYLRALVLYYRGQEGFSSARNILRQTLQMDPDNTKARVLLKRIRAVEAHKDAGNAAFKNKNAKVAVDEYTQAVECDPTNARMNATLRSNRAAAKMDLNDYKGALLDCDYAIKHGATSAKIYARRSRIQEQLENFDDAVRDMQQAAEEDGKFEAELRQLKARAKRAKRKDYYKILGLPQHEPNQDNIKRAYKKACLQWHPDKWANASEEEKSHAETQFKEIGEAFGVLSDPKKKRMYDSGQMDNDVEGANMSSSFGGGASQEDIVHVMNMMFGGSGFQAGSFSGAFGGPGNGRRRPRGAPNFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FM38</accession>
    <name>A0A836FM38_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_00676</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058853.1">
        <property type="nucleotide sequence ID" value="XM_067202752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836FM38"/>
    <dbReference type="SMR" id="A0A836FM38"/>
    <dbReference type="GeneID" id="92356686"/>
    <dbReference type="KEGG" id="loi:92356686"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5465222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="194" mass="21763" checksum="B2A02ABD28B422AA" modified="2021-09-29" version="1">MCFEMCEGIVSSQSERQPHPFHQLKCSRSIRNRAAVVYHLTCAKLQIKVPQDVLFSASLSYALNISRMSAKCPTLGQLRSVSNETDIVAVEMLIFEFVRPHVVLIEGCLRLELKRLVVHRPLPLNVRECVGRVAIALSDTLYACHYCLYPEAAARACLLKACERLSVDVNLATLPDEFRTPRVAEICAYLSALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FPC9</accession>
    <name>A0A836FPC9_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059447.1">
        <property type="nucleotide sequence ID" value="XM_067203756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836FPC9"/>
    <dbReference type="SMR" id="A0A836FPC9"/>
    <dbReference type="GeneID" id="92357690"/>
    <dbReference type="KEGG" id="loi:92357690"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5466557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="185" mass="20786" checksum="29198508B25BFBD8" modified="2021-09-29" version="1">MSFFERPHRLMSASSVVMGLKPETLREIDDYAVWMDKVRAELVAVYGEQAMGSDVSHITYATSDNPTRFSSCITRDVFERLRDYKALLGKIDSINRQVTEKTRLEEIMEAAIGQDTHDGKSLRQQQRDLLKLKASIAQLTRQEAELKYQLACVSPQLKNVFKADAVCISFALKQPSPSAAAVSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FTN3</accession>
    <name>A0A836FTN3_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_02458</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060039.1">
        <property type="nucleotide sequence ID" value="XM_067204487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836FTN3"/>
    <dbReference type="SMR" id="A0A836FTN3"/>
    <dbReference type="GeneID" id="92358421"/>
    <dbReference type="KEGG" id="loi:92358421"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5469062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="293" mass="33278" checksum="DEFDC970C681D227" modified="2021-09-29" version="1">MWTGSRPCLAAVRRTTALCQKKQTAAGYMASAGKVGSEEKWAQAAMEYIHEKNHVNDARKRQQDVDQERSIANAYDRYSAVAEAKFDERLSRLIARMSEALEEMRKLGLKGALEEAVLLNSEQPPGHYRRPSLTPPLLGYEPGFGLDVPQLRGQQAEYPPLRRPTDWLEFGEGGSDDFPYVDAHKIEDLAAKHERQLEEQHGVLREAAPLTGVEGEGWEAYVALHRKALARQHLIMDLHNDPELRNKYDTDEAFRAAEWKRRGMGTLDIEAPLERDVELHYAQVPAYEAFRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G064</accession>
    <name>A0A836G064_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Flagellum transition zone component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_00664</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058842.1">
        <property type="nucleotide sequence ID" value="XM_067202741.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92356675"/>
    <dbReference type="KEGG" id="loi:92356675"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="689"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="825"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="945"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1078"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1241"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1403"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="323"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="543"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="702"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="739"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="837"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="852"/>
            <end position="870"/>
        </location>
    </feature>
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        <location>
            <begin position="876"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="952"/>
            <end position="963"/>
        </location>
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        <location>
            <begin position="965"/>
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        </location>
    </feature>
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            <end position="1278"/>
        </location>
    </feature>
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        <location>
            <begin position="1315"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1412"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1465"/>
            <end position="1474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1475"/>
            <end position="1501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5465211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1501" mass="157116" checksum="BBB5D9AE675311A6" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G0B1</accession>
    <name>A0A836G0B1_9TRYP</name>
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        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_00756</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465301.1"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
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    <dbReference type="InterPro" id="IPR045262">
        <property type="entry name" value="STP/PLT_plant"/>
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    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
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    <dbReference type="InterPro" id="IPR005829">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="213"/>
            <end position="238"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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    <feature type="transmembrane region" description="Helical" evidence="9">
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <end position="403"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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        <location>
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            <end position="502"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="522"/>
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    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="47"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
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            <end position="39"/>
        </location>
    </feature>
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    </feature>
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        <location>
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            <end position="30"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
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            <begin position="612"/>
            <end position="629"/>
        </location>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5465301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="732" mass="79353" checksum="05DD6AD40CB9585B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G409</accession>
    <name>A0A836G409_9TRYP</name>
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        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_03892</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
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        <lineage>
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            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061823.1">
        <property type="nucleotide sequence ID" value="XM_067205886.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="92359820"/>
    <dbReference type="KEGG" id="loi:92359820"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="110"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="110"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="376"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="376"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5474717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="401" mass="42110" checksum="BC1031C1461EB281" modified="2021-09-29" version="1">MRPAQNSSAQASTGPADHTILSPNLRSPTNSTTGPRLFTHAPYLSPVHIISSEDLDAVEFAALGGMDRQRDRLDKRQGSPSSGGPHLCGASFNANCKNANQLRSPYGYSSGKKNVCRHFLNGSCNRGSSCHFYHPGPIHHVITPTRPNTPTQRPLTPLADLAQQNSAYVAQSPAHSPYMGPTSAQLRSSPRVPLMTLIIAGGSACSNTESFASPPSSPSTSFSAQRSTAFVETPAQVVPTAPALSSPSIGPNFSPGNSLGSRAQCGRGVSLLPSLQLLDYVPNCSDDGIVEVCNSVTAEDMGLLSRPHSPSSPGPCRMPMYRAGMQPGASCNSSCGERIEALANPHLLSGSVFLAATSEAVTSLIPGVVTRNNPYAYSPTRVQQHPSRLMGPLKRASNGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G4B0</accession>
    <name>A0A836G4B0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="14">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LSCM4_00795</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol III by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="14"/>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059518.1">
        <property type="nucleotide sequence ID" value="XM_067202868.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836G4B0"/>
    <dbReference type="GeneID" id="92356802"/>
    <dbReference type="KEGG" id="loi:92356802"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02736">
        <property type="entry name" value="RNAP_III_Rpc1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02583">
        <property type="entry name" value="RNAP_III_RPC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000008">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.180:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000015">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001497">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035698">
        <property type="entry name" value="RNAP_III_Rpc1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035697">
        <property type="entry name" value="RNAP_III_RPC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015700">
        <property type="entry name" value="RPC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00374">
        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="15">
        <location>
            <begin position="251"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG5467716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1588" mass="174224" checksum="5970BEB077C7B78C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G4M5</accession>
    <name>A0A836G4M5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DDB1- and CUL4-associated factor 12 beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_00997</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059713.1">
        <property type="nucleotide sequence ID" value="XM_067203063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G4M5"/>
    <dbReference type="GeneID" id="92356997"/>
    <dbReference type="KEGG" id="loi:92356997"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056151">
        <property type="entry name" value="Beta-prop_DCAF12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855:SF11">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855">
        <property type="entry name" value="WD40 REPEAT PROTEIN 12, 37"/>
        <property type="match status" value="1"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000023">
        <property type="protein sequence ID" value="KAG5478497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063158.1">
        <property type="nucleotide sequence ID" value="XM_067206711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GAR6"/>
    <dbReference type="GeneID" id="92360645"/>
    <dbReference type="KEGG" id="loi:92360645"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38148">
        <property type="entry name" value="BAR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38148:SF3">
        <property type="entry name" value="BAR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5478497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="25345" checksum="561CB178F88D1A84" modified="2021-09-29" version="1">MPTTVLSDEQSALIKKLKHACATYDTAARKYLGAVKDLDVALETLAIALRELSQGEDNVSVRARADGFCTAVDRHMANTSINASGGNREQPAPDAALAGTAGYPFANYMSDFTHEVSFAVEELKEVVKVAEKAKSKQDELMSRYTKKRGEVDSLEMKLARKNRGITSNEKFAAKVADRDAMKAQVVAGDEELSNIYQALLKKRTQTLLRVIDGVQTYSGKYFTHLSKTMNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GDA4</accession>
    <name>A0A836GDA4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_02725</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060300.1">
        <property type="nucleotide sequence ID" value="XM_067204748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GDA4"/>
    <dbReference type="SMR" id="A0A836GDA4"/>
    <dbReference type="GeneID" id="92358682"/>
    <dbReference type="KEGG" id="loi:92358682"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000111">
        <property type="entry name" value="Putative phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22785">
        <property type="entry name" value="Tc-R-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="3">
        <location>
            <begin position="87"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="4">
        <location>
            <begin position="161"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="5">
        <location>
            <begin position="175"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="528"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="581"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="591"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5470034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="603" mass="68251" checksum="AA824D06F37E92B9" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GDJ4</accession>
    <name>A0A836GDJ4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Chaperonin HSP60, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_02863</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060435.1">
        <property type="nucleotide sequence ID" value="XM_067204883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GDJ4"/>
    <dbReference type="SMR" id="A0A836GDJ4"/>
    <dbReference type="GeneID" id="92358817"/>
    <dbReference type="KEGG" id="loi:92358817"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000015">
        <property type="entry name" value="Chaperonin HSP60, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000592">
        <property type="entry name" value="PRK00013.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009487">
        <property type="entry name" value="PRK12849.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009488">
        <property type="entry name" value="PRK12850.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009489">
        <property type="entry name" value="PRK12851.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45633">
        <property type="entry name" value="60 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0346">Stress response</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="552"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="552"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="578"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5470169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="594" mass="64312" checksum="3DDCF40864F8C22C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GFM6</accession>
    <name>A0A836GFM6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_02047</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061120.1">
        <property type="nucleotide sequence ID" value="XM_067204083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GFM6"/>
    <dbReference type="GeneID" id="92358017"/>
    <dbReference type="KEGG" id="loi:92358017"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF687">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
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        <location>
            <begin position="481"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="47"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="281"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5472724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="994" mass="109316" checksum="9486E4FAFEEDD386" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GH21</accession>
    <name>A0A836GH21_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_03573</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061507.1">
        <property type="nucleotide sequence ID" value="XM_067205570.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="loi:92359504"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21389:SF0">
        <property type="entry name" value="ETOPOSIDE-INDUCED PROTEIN 2.4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21389">
        <property type="entry name" value="P53 INDUCED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="568"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="47"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="259"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5473504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="594" mass="63931" checksum="DB6F99BABA8976FD" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GJ47</accession>
    <name>A0A836GJ47_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059300.1">
        <property type="nucleotide sequence ID" value="XM_067203609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GJ47"/>
    <dbReference type="GeneID" id="92357543"/>
    <dbReference type="KEGG" id="loi:92357543"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5466410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="77" mass="8126" checksum="92D40FEC8A10D1E9" modified="2021-09-29" version="1">MQATCLISHSALPVGYGTRASASHHVPVLNAICCVALGAFKTCAKKQENLHSMRDDGGRSGGTKRTEQVLLLSSSAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GJ96</accession>
    <name>A0A836GJ96_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peroxisomal membrane protein PEX16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_07255</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peroxin-16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000015">
        <property type="protein sequence ID" value="KAG5483042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064538.1">
        <property type="nucleotide sequence ID" value="XM_067209155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GJ96"/>
    <dbReference type="SMR" id="A0A836GJ96"/>
    <dbReference type="GeneID" id="92363089"/>
    <dbReference type="KEGG" id="loi:92363089"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Pex16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13299">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13299:SF0">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08610">
        <property type="entry name" value="Pex16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="2" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU365003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5483042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="559" mass="60903" checksum="1C9F7F71F8F8FFB1" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GLQ5</accession>
    <name>A0A836GLQ5_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067203327.1"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A836GLQ5"/>
    <dbReference type="GeneID" id="92357261"/>
    <dbReference type="KEGG" id="loi:92357261"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5466128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="790" mass="83985" checksum="D5723B461FAE7B4D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GLW6</accession>
    <name>A0A836GLW6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_01378</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059123.1">
        <property type="nucleotide sequence ID" value="XM_067203432.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="92357366"/>
    <dbReference type="KEGG" id="loi:92357366"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
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        <property type="entry name" value="ComplexI_NDUFA9_subunit"/>
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        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 39 KDA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5466233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="373" mass="42797" checksum="168AE681A6713D9D" modified="2021-09-29" version="1">MSRRMFVRNMNGELSSTWRYGGAEANTMGVNVATFGATGILGHHIHAVNCYHGYTSILPFRFRSGMPSSVRQMRSSGDGTVGQNFDTDYEIDKEFVVKAILEKVDNVINVVGAWQEPACYENSQSWFSMEAINVEWPRMLARWSREMGILKFTHMSMVGADLNSPSKLLRQKRAAEIAVLEEFPTATIIRGTDIFAENDFTYSKYLKAQRYLKIVPVPNHGQRIHQPVFAGDLAEAAARSLLLDHTEGRIAELGGPVRFTTNDLLRWCSECNNQRHLTVHLPKIVFDIACHINERYPFHQGVLLGTKAPAWNKDWVDRQFIDNCAMPERDPDLLDWEDFGIPREDLYRMEEKYFITSVMWSKCSPYLDYGYRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GLX1</accession>
    <name>A0A836GLX1_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062437.1">
        <property type="nucleotide sequence ID" value="XM_067207134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GLX1"/>
    <dbReference type="GeneID" id="92361068"/>
    <dbReference type="KEGG" id="loi:92361068"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5476204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="357" mass="37659" checksum="824E2F15495AD786" modified="2021-09-29" version="1">MTASPFCTREALRVAPIREGVGFPRPFTSTSKTAADSTMGEGAEPPAECAAATARQSNPIVFDVGVKPVAHSARRRPRRCSDAGGARQTVRSECSSCARQDSTTDTEESAIGPAIGIAMQDVTSGAAHGEPSDADAARTATSSIWEHHFPDAPPHNSYSDACSASVPTLSADTANSVGCTEVPTVTAVEIEVPTQFTTAAGRAVCVRERRLLAADSPYWKLLRFDPAREALVVPPDSSIDECGDEEEVDGDDSGELYDTVSSAKRAAEQLPTDSAAALEGATSQSSYEGSASTVSPLAFTYAGYALLHSCVRRRRAASCPERFADSRSYPRMGGNAHYSLPPFSGFCAADGRPFYCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GM60</accession>
    <name>A0A836GM60_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_01533</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
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            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
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        <name type="scientific">Leishmania orientalis</name>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <sequence length="409" mass="44597" checksum="AF52A6095D761E10" modified="2021-09-29" version="1">MVPNLSIKAFIDSSIITSHLLAPHLFFPRAASNESTCNPPAETHQGTPSHTRIVQTHLFPIGANSGMRAAPTCLGRSTAASLRRYPCGSRACNADGASWAGWRRCRRAAGVTTATVDVTAIPVSSTSLCASRRAYYWPYPENLVPEGETTSPFQSSPVPSVRERIVREYALGPLFGSRTPSCVLGFAGSARDVLGRKGDVRRCVARILGKAELEVELGALLQAREMLLHRSGTDESPRLADGAGSRPDAERRRVTRYARLPVQARTLLEVYLPGEEQGGAGVSADADATILAHGYFLQEQLYRYMNAAASSASEASDREGIHGNEHEEAGGKMQPSSQEDRQRDDEADLRASVAALHDTCGVVYCEVPALDESDFVFEQLNGKRVDSEMLDRVMGRWERRVAQQQQQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067206290.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="1363"/>
            <end position="1382"/>
        </location>
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            <dbReference type="ARBA" id="ARBA00022723"/>
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        <source>
            <dbReference type="PROSITE" id="PS01358"/>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GNS6</accession>
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    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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    <feature type="transmembrane region" description="Helical" evidence="5">
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    <feature type="transmembrane region" description="Helical" evidence="5">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="394"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="429"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="466"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="493"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="526"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="569"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="Nodulin-like" evidence="6">
        <location>
            <begin position="42"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5485367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="625" mass="68722" checksum="526094C3DB6CE41C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GP75</accession>
    <name>A0A836GP75_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MMS19 nucleotide excision repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_06548</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MET18/MMS19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000010">
        <property type="protein sequence ID" value="KAG5485592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065176.1">
        <property type="nucleotide sequence ID" value="XM_067208465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GP75"/>
    <dbReference type="SMR" id="A0A836GP75"/>
    <dbReference type="GeneID" id="92362399"/>
    <dbReference type="KEGG" id="loi:92362399"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039920">
        <property type="entry name" value="MMS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029240">
        <property type="entry name" value="MMS19_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12891">
        <property type="entry name" value="DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12891:SF0">
        <property type="entry name" value="MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14500">
        <property type="entry name" value="MMS19_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MMS19 N-terminal" evidence="2">
        <location>
            <begin position="48"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5485592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="956" mass="104157" checksum="E2798F6147D0EC94" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GQ34</accession>
    <name>A0A836GQ34_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_05322</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5477929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062836.1">
        <property type="nucleotide sequence ID" value="XM_067207268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GQ34"/>
    <dbReference type="SMR" id="A0A836GQ34"/>
    <dbReference type="GeneID" id="92361202"/>
    <dbReference type="KEGG" id="loi:92361202"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF22">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="7">
        <location>
            <begin position="56"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5477929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="431" mass="47803" checksum="8AD27821B229D43E" modified="2021-09-29" version="1">MLRHRCSSAVVGTGASLAPVCCRRARSTSYFSAVQRAPPDAIMGIAADFAKDMCPNKVNLCIGVYRDEQNKPFVLESVRKAMAHIVERDTQMDYAPIAGLPSFVNSVQRLCFGKPMLDVQGDRIASVQTLSGTGALHLGVGLLQYSSGGSGPATLHIPSPSYPNHLNILQQSNVKACHYPYYNLQTHRLNIDAMLNYLRQLPASSVVLLHACAHNPTGCDPTPEEWQQIVDVIRRCDLVPFVDMAYQGFATGDIEHDAYVLRALNQQEIPTYLVAQSLAKSFGLYGHRTGALHIRCTTQKEKANVLSQLRSTIRATYSNPPIFGARIADEILRTPQLRELWKSELHQMSSRLQDVRHRLVAQLRACGSTRDWEYLEKGVGMMSLTGLTEEQVIALQQKYSVYLTRNSRIAFSGLSSENVAYVAQAIHDVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GR09</accession>
    <name>A0A836GR09_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_02914</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the type 2 lipid phosphate phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060486.1">
        <property type="nucleotide sequence ID" value="XM_067204934.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="92358868"/>
    <dbReference type="KEGG" id="loi:92358868"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0042392">
        <property type="term" value="F:sphingosine-1-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
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        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
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        <property type="entry name" value="DIHYDROSPHINGOSINE 1-PHOSPHATE PHOSPHATASE LCB3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE"/>
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        <property type="entry name" value="PAP2"/>
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    </dbReference>
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        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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        <location>
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        <location>
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        <location>
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            <end position="481"/>
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            <begin position="237"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5470220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="615" mass="67112" checksum="B075F185239BCF2C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GR85</accession>
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        <recommendedName>
            <fullName evidence="5">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="3" type="ORF">LSCM4_03035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG5470340.1"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="27"/>
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    </feature>
    <feature type="chain" id="PRO_5032916325" description="AB hydrolase-1 domain-containing protein" evidence="2">
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            <begin position="28"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="559"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5470340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="605" mass="65963" checksum="DF7DF2E781A578C1" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GTC6</accession>
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        <recommendedName>
            <fullName evidence="3">Importin N-terminal domain-containing protein</fullName>
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        <name evidence="1" type="ORF">LSCM4_03652</name>
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        <lineage>
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            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG5473582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="ARM-like"/>
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        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
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        <property type="entry name" value="IMPORTIN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5473582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1095" mass="120981" checksum="46448B8D9D3FF246" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836GU79_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SKP1 component dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_02671</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Kinetoplastea</taxon>
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            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5469983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060249.1">
        <property type="nucleotide sequence ID" value="XM_067204697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GU79"/>
    <dbReference type="GeneID" id="92358631"/>
    <dbReference type="KEGG" id="loi:92358631"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5469983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="239" mass="26444" checksum="D31AD97064799B9B" modified="2021-09-29" version="1">MPVAAARDLSGKAPLFVYLNDGERERLPTGEYIRVVAQSSGTDKTVNRRDFALHLRGARLCRLLDSLLDSVDVDLKRKTDPLQGLIPPVVLPHATREGCECVFRYLDLIQTRVPTLLSKPLRAPLEELVHDWEMTYLLEDCFSPGVAGESKSSSALCRLLAKKGPQALDLVLEVAMIADFLLIEPLRDLTCALLASLALSAGSQKELLRLCGLDHALTEEELEPLYMQLPFLRPEDGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GUB7</accession>
    <name>A0A836GUB7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NADH-cytochrome b5 reductase</fullName>
            <ecNumber evidence="10">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_01818</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">LSCM4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="10"/>
    <dbReference type="EMBL" id="JAFHLR010000022">
        <property type="protein sequence ID" value="KAG5479229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063322.1">
        <property type="nucleotide sequence ID" value="XM_067203863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GUB7"/>
    <dbReference type="SMR" id="A0A836GUB7"/>
    <dbReference type="GeneID" id="92357797"/>
    <dbReference type="KEGG" id="loi:92357797"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000032">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000009">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF131">
        <property type="entry name" value="B5 REDUCTASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 10" id="KW-0274">FAD</keyword>
    <keyword evidence="4 9 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 10" id="KW-0520">NAD</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="11">
        <location>
            <begin position="36"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5479229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="289" mass="32293" checksum="BFD5956F7B89029A" modified="2021-09-29" version="1">MKAFIAAVTGFAASSWYNSFSNSTNCATPSSPFSQSEFRSFPLMDVYDESHNTKVFRFALPEADMPLNLEVASCVSFRFLDKDGKEVIRPYTPLSRSDQRGYFDVLVKKYQGSKMGTHLFAMKKGDTIDVKGPWVKLPVKANQYKMIGMIAGGTGITPMYQVARHVLHAPKNSTEITLIYANERKEDVLLGNELNELMETYPRFSPYFVLSKAPSDWMGGVGFVNKEMIKSLMPTPNRAGDSIILVCGPPPFMEAISGDKDFTSNPPSQGDLKGYLKELGYMPKMVYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GV16</accession>
    <name>A0A836GV16_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000017">
        <property type="protein sequence ID" value="KAG5481846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064206.1">
        <property type="nucleotide sequence ID" value="XM_067208832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GV16"/>
    <dbReference type="SMR" id="A0A836GV16"/>
    <dbReference type="GeneID" id="92362766"/>
    <dbReference type="KEGG" id="loi:92362766"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="527"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="568"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="761"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5481846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="816" mass="87709" checksum="399C62B6B63BFCF2" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GVU6</accession>
    <name>A0A836GVU6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA replication licensing factor MCM6</fullName>
            <ecNumber evidence="12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LSCM4_04004</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061933.1">
        <property type="nucleotide sequence ID" value="XM_067205996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GVU6"/>
    <dbReference type="SMR" id="A0A836GVU6"/>
    <dbReference type="GeneID" id="92359930"/>
    <dbReference type="KEGG" id="loi:92359930"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990518">
        <property type="term" value="F:single-stranded 3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902969">
        <property type="term" value="P:mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001327">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000021">
        <property type="entry name" value="DNA replication licensing factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.870:FF:000005">
        <property type="entry name" value="Putative DNA replication licensing factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008049">
        <property type="entry name" value="MCM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041024">
        <property type="entry name" value="Mcm6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF43">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18263">
        <property type="entry name" value="WHD_MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01662">
        <property type="entry name" value="MCMPROTEIN6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="14">
        <location>
            <begin position="388"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="715"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="732"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG5474827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="877" mass="96637" checksum="B102A574CC028E57" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GZI6</accession>
    <name>A0A836GZI6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HECT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_01129</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5468041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059843.1">
        <property type="nucleotide sequence ID" value="XM_067203193.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836GZI6"/>
    <dbReference type="GeneID" id="92357127"/>
    <dbReference type="KEGG" id="loi:92357127"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000036">
        <property type="entry name" value="Ubiquitin-protein ligase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000078">
        <property type="entry name" value="Ubiquitin-protein ligase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045322">
        <property type="entry name" value="HECTD1/TRIP12-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670:SF15">
        <property type="entry name" value="LIGASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="5">
        <location>
            <begin position="1211"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="227"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="358"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="252"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="358"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="371"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="1337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5468041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1370" mass="149444" checksum="E3D676016851CA0E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H0N6</accession>
    <name>A0A836H0N6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">S1 motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_04823</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000014">
        <property type="protein sequence ID" value="KAG5483674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064613.1">
        <property type="nucleotide sequence ID" value="XM_067206804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H0N6"/>
    <dbReference type="SMR" id="A0A836H0N6"/>
    <dbReference type="GeneID" id="92360738"/>
    <dbReference type="KEGG" id="loi:92360738"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22525">
        <property type="entry name" value="KH-I_Rrp4_eukar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05789">
        <property type="entry name" value="S1_Rrp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048565">
        <property type="entry name" value="S1_RRP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321:SF4">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PNAS-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15985">
        <property type="entry name" value="KH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21266">
        <property type="entry name" value="S1_RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0271">Exosome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1 motif" evidence="5">
        <location>
            <begin position="82"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5483674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="295" mass="31395" checksum="3366E7EB46FC9A13" modified="2021-09-29" version="1">MSSGVVIVGDSICGGNTDQKLCTGLEVYLRGFNTFSGNHPSDVALLHEGAGEIVAAINGHIEVTDRVISVKGLLPRYQPEIGDVVVGRISEVTGNKWQVDVNSTQSAVMLLSNVTEPGGILRRRGRDDELGMRQLFDQGDLVAAEVQRITPDGVVSLHTRAAGKYGRLSGLGILVSVRPSLVKRAKHQFVELAEYSTQLIIGMNGNIWVCAVHSCAADTSGKEHAADARQNVARVVNCIKALGAARVQINPASIEASVVASLEAGLSAFDLSIEKHQGALLARVADTVGMKRRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H0R1</accession>
    <name>A0A836H0R1_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_00918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059635.1">
        <property type="nucleotide sequence ID" value="XM_067202985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H0R1"/>
    <dbReference type="SMR" id="A0A836H0R1"/>
    <dbReference type="GeneID" id="92356919"/>
    <dbReference type="KEGG" id="loi:92356919"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5467833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="565" mass="60831" checksum="63FDC8684A483D8A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H199</accession>
    <name>A0A836H199_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Homologous-pairing protein 2 winged helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_04325</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HOP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062248.1">
        <property type="nucleotide sequence ID" value="XM_067206311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H199"/>
    <dbReference type="GeneID" id="92360245"/>
    <dbReference type="KEGG" id="loi:92360245"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120231">
        <property type="term" value="C:DNA recombinase auxiliary factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120230">
        <property type="term" value="F:recombinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007129">
        <property type="term" value="P:homologous chromosome pairing at meiosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000709">
        <property type="term" value="P:meiotic joint molecule formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010774">
        <property type="term" value="P:meiotic strand invasion involved in reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010776">
        <property type="entry name" value="Hop2_WH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15938:SF0">
        <property type="entry name" value="HOMOLOGOUS-PAIRING PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15938">
        <property type="entry name" value="TBP-1 INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07106">
        <property type="entry name" value="WHD_TBPIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032314251" description="Homologous-pairing protein 2 winged helix domain-containing protein" evidence="6">
        <location>
            <begin position="30"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Homologous-pairing protein 2 winged helix" evidence="7">
        <location>
            <begin position="165"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5475740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="429" mass="46623" checksum="61D12079BA8E8B7C" modified="2021-09-29" version="1">MIWDGAGGEPVCVVCACVLFFLRLRASQSCSNVPHPRLPSLSPSAPVCVPFGVSLHTPTPLHAHPPFAFSPAAVHCNAAARLVALRFGQGSPLVAVIRIVRARWCLSLRHVCLLCQTRPCVYTTTFPSLAIYTFTHISSPSLSRTSCSSMGTCKTDIKKVKDVAEATALVLDWFQRHNKPVTPQSLTDALGSRVAKPLVQKILEQLHAEETLYAKDMKKIRFYYLRVLPLPDPSSATTTEPNGETEEKAVATADKGGAVTSAPHVGGGSEACGESPADVHAALLHAVVTTAVQLSQRSHRLARWRGCPSSAERAAKSADLARDVGELRESLERHQSRYAGEPTEAHGASSWVWRARRAVCRYRRARRHWLQRKEWAMCLLEATAGDAHTPVQVAALLGCTTDVEVGVSFEETAVALPAALLRELRLSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H1X0</accession>
    <name>A0A836H1X0_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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                <person name="Bates M.D."/>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Bates M.D."/>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Jariyapan N."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Thomaz Soccol V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
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            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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            </authorList>
            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
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            <taxon>Kinetoplastea</taxon>
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            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5487276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="3034" mass="313963" checksum="FD19D64A1C0E0602" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H727</accession>
    <name>A0A836H727_9TRYP</name>
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        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_06700</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000009">
        <property type="protein sequence ID" value="KAG5485994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065325.1">
        <property type="nucleotide sequence ID" value="XM_067208614.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="loi:92362548"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
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        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
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    </dbReference>
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        <property type="entry name" value="RRM"/>
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    </dbReference>
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        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
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        <location>
            <begin position="104"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5485994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="299" mass="31410" checksum="8014C96646BA6CE7" modified="2021-09-29" version="1">MTLNFDILAGSNADWGFDCLPAAPERSPTPALFTPFGVTAGTDSDLLLLSALQVPAPRVMSGSMQTMAQSVPVSDSGENVSPMKNDSLNMSVQASDPAARAYDSNLYVASLPEWFTDADLHELFKRFGPIVSAKVMCHKGTHHCKGYGFVLFQRTDDAAVARSEMIGHVVGGNKIQVRRARSAASAPLTEAASATSGTFTDSSGTTRASSSNVTPINYAAHLVPTQQPPFHPLYPATTTMTPTYVLTNASGSLPNAAHPQPAVLVAIPNGSTAARGAGDVMYMVLASSAQQMQSTNAIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H997</accession>
    <name>A0A836H997_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arf-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_03474</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
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    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061414.1">
        <property type="nucleotide sequence ID" value="XM_067205477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H997"/>
    <dbReference type="SMR" id="A0A836H997"/>
    <dbReference type="GeneID" id="92359411"/>
    <dbReference type="KEGG" id="loi:92359411"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08204">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="stromal membrane-associated protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051718">
        <property type="entry name" value="ARF_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705:SF1">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="86"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="333"/>
            <end position="386"/>
        </location>
    </feature>
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        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="237"/>
            <end position="253"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5473411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="386" mass="41259" checksum="EF16A3BBCCE371DF" modified="2021-09-29" version="1">MSFQDPEKPALAAAEVPVVDKPRERRHRVSKEDSAGGSRHHHHHSHDKKKRRKSADASTSSPTTSSAPKRRDAAANEEEEDWEGNRAAVERICAQYPNNVCADCGETGTRWASVNHGVFVCIRCSGVHRSLGVHISKVKSTNMDRWLLAEVCLMGAIGNAKAKALYEAHLPAGVRPAGGAGAAADDAIKSFIQRKYAQREFAMHNLKDVLGRLYKDTGYGRPKRASKPGAAAEGPLSSSMRASSSAAAPVDRAAVAGQRNDTMRALYGDAAAEMHRGASRKEKNAAALSAAASAPKPTYGTFGMVNVPPEEYEARWQRTLAVFSFVDAPQAADLAPEEEMPSRDQKEMSAAAETSLPDPNDTLAGRSLMGGAEATPEAVADTSFTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H9Q7</accession>
    <name>A0A836H9Q7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_02015</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="2"/>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061089.1">
        <property type="nucleotide sequence ID" value="XM_067204052.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836H9Q7"/>
    <dbReference type="GeneID" id="92357986"/>
    <dbReference type="KEGG" id="loi:92357986"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000027">
        <property type="entry name" value="Ubiquitin-protein ligase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000039">
        <property type="entry name" value="Ubiquitin-protein ligase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF2">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="7">
        <location>
            <begin position="1054"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="631"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="650"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="5">
        <location>
            <position position="1365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5472693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1397" mass="152214" checksum="2D9C84075E715702" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H9R9</accession>
    <name>A0A836H9R9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Prokaryotic-type class I peptide chain release factors domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_02286</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061356.1">
        <property type="nucleotide sequence ID" value="XM_067204319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H9R9"/>
    <dbReference type="GeneID" id="92358253"/>
    <dbReference type="KEGG" id="loi:92358253"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052405">
        <property type="entry name" value="Mito_Transl_Release_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46203:SF1">
        <property type="entry name" value="MITOCHONDRIAL TRANSLATION RELEASE FACTOR IN RESCUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46203">
        <property type="entry name" value="PROBABLE PEPTIDE CHAIN RELEASE FACTOR C12ORF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5472960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="464" mass="51963" checksum="CC25CDC5E7E2D936" modified="2021-09-29" version="1">MHALVTRRAAVVLRSSVFSHTIFDCACFVHASEGVVKRPSRRRYAAVNTRGRVGQAKELVDMMRKKPALEAQAFFDALQPRDKLDIMRLLSKRRKNRQSGCASCHLSKYYSVPFEKNYFFREEDVEEESTLGRGPGGQATNRRMQTAILKHVPSGLIVKFSRFPSLWLNRRAARELLSLRLEEHLLGPASRLGKARVARERRRQQRQRTIAYLREKGARLQARDTRRCNWLAFLTGKSPLPRAAVSQMALEENAAAVPVTTAVLFGSECNAWWPKLRAATERAAAAAADGSGGDDVPLLVQYLFPAVYPDSSRAERDEMAACKSNKAVHTNVLRALACFCEVFGLRLRHIPASAPTEASRVFLEKDGLNWVEHRSRMIKNGSLTQLARACWPRVYMSLRELGMTSEARAVALFFKKEVKAAAGSATVVWAAEALECLAEEVRRSKSPAAAQMSRVTFSRATRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HBS9</accession>
    <name>A0A836HBS9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycoprotein 96-92</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061912.1">
        <property type="nucleotide sequence ID" value="XM_067205975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HBS9"/>
    <dbReference type="SMR" id="A0A836HBS9"/>
    <dbReference type="GeneID" id="92359909"/>
    <dbReference type="KEGG" id="loi:92359909"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5474806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="507" mass="61134" checksum="1C0255E31C565989" modified="2021-09-29" version="1">MSSPPSALAEQHIDPAPASSDAFPKDTSAPSASAGNSVYTNGTGNGKLQAGVSTTKKRLLRKDNRGAVALQVAKRGKEENKRLADEIAKAREAEAQAAREKARRVRQAEAERRKKRDERDARALKDLREDRKQKEEQQQQAEREREERQRAEMVRKQREEAQRKREAIQKQREEEIKRRKADVEAEKQKLKELQEEHEREQEEARQRRVAEEREAQKRSEKKAEEAEDEFAAARRQRKGELEELHRKREEEEKQRVEMVRKQREEAQRKREEIQKQREEEIKRRKADVEAEKQKLKELQEEHEREQEEARKRRVAEEREAQKRSEKKAEEAEDEFAAARRQRKGELEELHRKREEEEKQRVEMVRKQREEAQRKKEKLRQRECEKAKEVKRLLKEEQARLQEEREREQQARRKMIQARRAKGKKDVREQILKEKRRAAAAERERLEEESRKRKEEEEKELEAKRKRVMEQLEKNYDIVDEEEYERERQRLRQEKEHESATAEDFRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HFA1</accession>
    <name>A0A836HFA1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_04292</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062216.1">
        <property type="nucleotide sequence ID" value="XM_067206279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HFA1"/>
    <dbReference type="GeneID" id="92360213"/>
    <dbReference type="KEGG" id="loi:92360213"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000535">
        <property type="entry name" value="MSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50202">
        <property type="entry name" value="MSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MSP" evidence="4">
        <location>
            <begin position="5"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="190"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5475708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="336" mass="36331" checksum="F156410677E161E9" modified="2021-09-29" version="1">MTSGTLQVKLSQDSLFFPLPFTNATIDNVVQVKNTLPVVQGDPKANVISFKILSRVQYRYSVRPPVGFIGAGEYVTIVFSFNPEHVKMSKNPEERELPTEATKDAIHVDFAVVDAQLVPTALAHWVPGSKDAKMSREIMADASQFWKKVGQVKKNSPTMMRYKLKCVFATRNNVPDSLVMCMKEEDDKAKATADNAAPLPRARPPMTSSTQPQSPVPPEAPPHRHSESQRTTPTASTPCNDAVYSPCSAGASGISPRPSAASAASASFALSPSSALAQRWSASAGSTDSAVTLNDIAEQVMHYKLSYQMAGVLLCLTLLCGLFDQSNLLTWLLAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HGC5</accession>
    <name>A0A836HGC5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Adenosine deaminase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_06630</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000010">
        <property type="protein sequence ID" value="KAG5485672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065256.1">
        <property type="nucleotide sequence ID" value="XM_067208545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HGC5"/>
    <dbReference type="GeneID" id="92362479"/>
    <dbReference type="KEGG" id="loi:92362479"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006154">
        <property type="term" value="P:adenosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046103">
        <property type="term" value="P:inosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409:SF42">
        <property type="entry name" value="ADENOSINE DEAMINASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="328"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="527"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="328"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="536"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5485672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="728" mass="78744" checksum="A36FE9117007713C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HJZ9</accession>
    <name>A0A836HJZ9_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_08082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000005">
        <property type="protein sequence ID" value="KAG5487637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065925.1">
        <property type="nucleotide sequence ID" value="XM_067209958.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92363892"/>
    <dbReference type="KEGG" id="loi:92363892"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="676"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="849"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1091"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="606"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="629"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="686"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="909"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="926"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="953"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="973"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1100"/>
            <end position="1110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5487637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1287" mass="131382" checksum="BBA4B5D7372204B4" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HKM2</accession>
    <name>A0A836HKM2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCR4-NOT transcription complex subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_04610</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CNOT11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000023">
        <property type="protein sequence ID" value="KAG5478378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063039.1">
        <property type="nucleotide sequence ID" value="XM_067206592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HKM2"/>
    <dbReference type="GeneID" id="92360526"/>
    <dbReference type="KEGG" id="loi:92360526"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019312">
        <property type="entry name" value="CNOT11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15975">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15975:SF0">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
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            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5478378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="433" mass="48718" checksum="DDDBC5B9E26507D4" modified="2021-09-29" version="1">MSVEFLTPAERSRLLDALLDSTSSFGNLSKRFREGFQPSRYSAVSLEMGQICKEFVASTESTGLIAALYLMAYMQKQDNVAAKSTFYEVLIELEHAIRRDMFIVEQIKYTTKESKESKKSMEATRAEIFRIHCAAKVFAFQLLGDAVADEEKVVSYASKKQESIDEALNAWERASIKIKEPMADIEHCWVASHEKQQCGSLYETAAVFDEQPNKTFALLLPSVTAKLPMLPLQEGELHYLLPEKSAMLLLDSAVPSEGWMTCKRLLVEARRFKLSKDDEVLLLGLLNESLVSRLGVCPQQLSELATYNPEVCASVLLKVASGSAGAFIQFLLKGNIPEDNMQTILLRASSVLQQVNMRTFISTMIHRFKEKGGSPTSVESLNSFALTLHQLVMKAAKENREIFIADAFRSDLEQLFHASNNPELKSRWEEMKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836HM17_9TRYP</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">LSCM4_06243</name>
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        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
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            <taxon>Eukaryota</taxon>
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            <taxon>Euglenozoa</taxon>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000020">
        <property type="protein sequence ID" value="KAG5480476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067208167.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="loi:92362101"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="633"/>
            <end position="659"/>
        </location>
    </feature>
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        <location>
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            <end position="1053"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1087"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="885"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="923"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="956"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="986"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1108"/>
            <end position="1141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5480476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1248" mass="131991" checksum="AC49E1A9F584DB75" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HTK4</accession>
    <name>A0A836HTK4_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_05609</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000016">
        <property type="protein sequence ID" value="KAG5482353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064359.1">
        <property type="nucleotide sequence ID" value="XM_067207545.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="92361479"/>
    <dbReference type="KEGG" id="loi:92361479"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070260">
        <property type="term" value="F:5'-tyrosyl-DNA phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051547">
        <property type="entry name" value="TDP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15822">
        <property type="entry name" value="TRAF AND TNF RECEPTOR-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15822:SF4">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="57"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
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            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="288"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
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            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="664"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="221"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
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            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="668"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5482353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="735" mass="77988" checksum="A727F49A4566DADF" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HTM6</accession>
    <name>A0A836HTM6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Ubiquitin-fold modifier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_05641</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Ubiquitin-like modifier.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the UFM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000016">
        <property type="protein sequence ID" value="KAG5482383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064389.1">
        <property type="nucleotide sequence ID" value="XM_067207575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HTM6"/>
    <dbReference type="SMR" id="A0A836HTM6"/>
    <dbReference type="GeneID" id="92361509"/>
    <dbReference type="KEGG" id="loi:92361509"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990592">
        <property type="term" value="P:protein K69-linked ufmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000044">
        <property type="entry name" value="Ubiquitin-fold modifier 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005375">
        <property type="entry name" value="UFM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15825">
        <property type="entry name" value="UBIQUITIN-FOLD MODIFIER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15825:SF0">
        <property type="entry name" value="UBIQUITIN-FOLD MODIFIER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03671">
        <property type="entry name" value="Ufm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038027">
        <property type="entry name" value="Ubiquitin-like_Ufm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR038027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5482383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="105" mass="10990" checksum="845882DF6BFBDEB6" modified="2021-09-29" version="1">MSSSTQQGAPAAPSGNKVTFRVILTSERSQPFRVISIAEEAPLTAVLRFAAEEFGIASVDSMAATTKDGTGINPAQTAGTVFMKYGQEIRLIPRDRVGGAAASIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HV42</accession>
    <name>A0A836HV42_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Voltage-dependent anion-selective channel</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_08172</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000002">
        <property type="protein sequence ID" value="KAG5488193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066241.1">
        <property type="nucleotide sequence ID" value="XM_067210043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HV42"/>
    <dbReference type="GeneID" id="92363977"/>
    <dbReference type="KEGG" id="loi:92363977"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008308">
        <property type="term" value="F:voltage-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001925">
        <property type="entry name" value="Porin_Euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743:SF70">
        <property type="entry name" value="GH26960P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION-SELECTIVE CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5488193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="30735" checksum="E48E08FA0D98A688" modified="2021-09-29" version="1">MKTYSTPALFKDYNKSTRDLLSKNFPTPDKWVLECKHSGPRDTFFINPHANSDGKLSADIEYVAACNGGVKITVSPDIMREIKGTAHYTLNGHKVEVTLHRLKEKVRYEISHETCVALSKRASINEKLTPENVELGMGIDVAPNCQVGCGAVYDIAANNCNWNIGCRYADKGFEVAVRTNCLKTYHTSASAPCSFMLLGNKCTVRAAVEVECGRCRGDKGVAVTAGIESTCPVLPANTLKARVNRDMKWMVAYAAKMADNWTACVSMDDNMKLGVQLTHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HYG3</accession>
    <name>A0A836HYG3_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_07597</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000012">
        <property type="protein sequence ID" value="KAG5484828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064940.1">
        <property type="nucleotide sequence ID" value="XM_067209480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HYG3"/>
    <dbReference type="GeneID" id="92363414"/>
    <dbReference type="KEGG" id="loi:92363414"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5484828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="104" mass="11500" checksum="D0E2F71D104825FB" modified="2021-09-29" version="1">MLATATVSEAEASLAGQCSSDHVQFEGVQLKEASAKDLYVTTLERQLLRMSAMEQLRTCCFADPQLPAAADVDKDCLLRSALRDSVRVFLSLMLFLCLETHFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HZA2</accession>
    <name>A0A836HZA2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_06546</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Sodium-phosphate symporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000010">
        <property type="protein sequence ID" value="KAG5485590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065174.1">
        <property type="nucleotide sequence ID" value="XM_067208463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HZA2"/>
    <dbReference type="SMR" id="A0A836HZA2"/>
    <dbReference type="GeneID" id="92362397"/>
    <dbReference type="KEGG" id="loi:92362397"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101:SF96">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="262"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="262"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5485590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="493" mass="52450" checksum="61DAAD6F4066C20E" modified="2021-09-29" version="1">MTDVNPYLWIVVVGSFVSFLTGAGVGMNDLANAFGTTYGARILTLTQIVLVASVCEFAGAVTLGGAVTSTISSGIADPKDFKGQPYVFMYGMLCACGAAFCWLAIATWLRLPVSSTHSICGGVIGFALVYGGSDTVSWAKRKDEFPFFNGVAPIVASWFISPVLTGIVSALIYSLVRFLVLRPKNCVKRAIYTLPIIVTVAFFLEAFFVLFKGASKRLKWSVNKAAWVAACIGAGAGVLSCAFIPLLKRLVARDEARALAAAEERPSTTEDSSNREPLNGEDMRKAREVTGDVVSESEASDSERSGERQVTGASGLQVQQYEWRAERVFRYLQVFTAICASFAHGASDVSNAVGPLAAIYQVYKTGSVEKSSSVPIWVLCLGGVGLVVGLATFGIRLLRLMGEDLTVITPSRGFSAELAAALVVSFASGYGIPVSSTHCITGGVIAISIVDVGFMNIRWIMVLKMYGGWVFTLVITAIFSATFFAQGTSAPAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836I4Q2</accession>
    <name>A0A836I4Q2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Actin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_07584</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000004">
        <property type="protein sequence ID" value="KAG5487903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066100.1">
        <property type="nucleotide sequence ID" value="XM_067209468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836I4Q2"/>
    <dbReference type="SMR" id="A0A836I4Q2"/>
    <dbReference type="GeneID" id="92363402"/>
    <dbReference type="KEGG" id="loi:92363402"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000205">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000047">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000018">
        <property type="entry name" value="Actin-like protein (Centractin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5487903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="376" mass="42152" checksum="AFE01144757EE093" modified="2021-09-29" version="1">MADYEQNAIVCDNGSGMVKAGFSGDDAPRHVFPSIVGRPKNMQAMMGSANKTVYVGDEAQSKRGVLSLKYPIEHGIVTNWDDMEKIWHHTFYNELRVNPEQHNVLLTEAPMNPKQNREKMTQIMFETFNVPSLYIGIQAVLSLYSSGRTTGIVLDAGDGVTHTVPIYEGYSLPHAVRRVDMAGRDLTEYLMKIMMETGMTFTTTAEKEIVRNVKEQLCYVALDFEEEMTNSAKSANEEAFELPDGNVMMVGNQRFRCPEVLFKPSLIGLDEAPGFPEMVYQSINKCDIDVRRELYGNIVLSGGSTMFRNLPERLAKEISNLAPSSIKPKVVAPPERKYSVWIGGSILSSLTTFQTMWVKKSEYDESGPSIVHNKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836K6E4</accession>
    <name>A0A836K6E4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Developmentally regulated GTP-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_00235</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058425.1">
        <property type="nucleotide sequence ID" value="XM_067202324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836K6E4"/>
    <dbReference type="SMR" id="A0A836K6E4"/>
    <dbReference type="GeneID" id="92356258"/>
    <dbReference type="KEGG" id="loi:92356258"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
        <property type="entry name" value="DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17230">
        <property type="entry name" value="TGS_DRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000003">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000740">
        <property type="entry name" value="Putative GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1070">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="64"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="4">
        <location>
            <begin position="289"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5464794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="41024" checksum="FDC751F89D1EA021" modified="2021-09-29" version="1">MSSLQKINDIEAELARTQKNKATMAHICALKARLAQLKRELISSESKKGGGKGEGFDVQKTGDARIGFIGFPSVGKSTLLSKMTSTHSEVAAYEFTTLTCVPGVVNYRGAKLQMLDLPGIIEGAKDGKGRGRQVIAVARTCSLILIVLDIAKPLQHKLIIERELDGFGIRLNKSPPDIVIRKKDRGGISISSTCPLTNLDQETIKTILGEYRMSNADITFRGDYTADEFIDAIEGNRAYIPAIYVLNKIDQISVEELDIVARIPHNCPISAHHEWNLDGLLECIWDHLNFIRVYTKPKGQVPDYDAPVILKKSPQPSVEGFCNRIHRQLMRNYKYAWVWGSSVKHQPQRVGKDHPLEDEDVVQVVKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KA71</accession>
    <name>A0A836KA71_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_00102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058293.1">
        <property type="nucleotide sequence ID" value="XM_067202192.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836KA71"/>
    <dbReference type="GeneID" id="92356126"/>
    <dbReference type="KEGG" id="loi:92356126"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032845725" evidence="1">
        <location>
            <begin position="31"/>
            <end position="1640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5464662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1640" mass="184230" checksum="CDFB6F397E2AD2BA" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KAC1</accession>
    <name>A0A836KAC1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Centrosomal protein 20</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">FGFR1OP N-terminal-like protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">LisH domain-containing protein FOPNL</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LSCM4_02511</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the biogenesis of cilia. Required for the recruitment of PLK1 to centrosomes and S phase progression.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Microtubule organizing center</location>
            <location evidence="3">Centrosome</location>
            <location evidence="3">Centriolar satellite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic granule</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CEP43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060091.1">
        <property type="nucleotide sequence ID" value="XM_067204539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KAC1"/>
    <dbReference type="SMR" id="A0A836KAC1"/>
    <dbReference type="GeneID" id="92358473"/>
    <dbReference type="KEGG" id="loi:92358473"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030030">
        <property type="term" value="P:cell projection organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034453">
        <property type="term" value="P:microtubule anchoring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.960.40:FF:000002">
        <property type="entry name" value="LisH domain-containing protein FOPNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018993">
        <property type="entry name" value="FOP_dimerisation-dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15431">
        <property type="entry name" value="FGFR1 ONCOGENE PARTNER/LISH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15431:SF4">
        <property type="entry name" value="PROTEIN TONNEAU 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09398">
        <property type="entry name" value="FOP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGFR1 oncogene partner (FOP) N-terminal dimerisation" evidence="13">
        <location>
            <begin position="59"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00076755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00081996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG5469114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="127" mass="13983" checksum="5884816160C17057" modified="2021-09-29" version="1">MSSQESLKAAMRESLETNGTISRIKAELRAAIFERLSDVTANGDGRAVENPPMPPENMVINELIKEYLTFNGLEHTLAVFQLEARSPDSQVPRRVLASELNMAAAPSSVPLLYAMLHEARLSKDMGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KBE3</accession>
    <name>A0A836KBE3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MP18 RNA editing complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_00070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058261.1">
        <property type="nucleotide sequence ID" value="XM_067202160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KBE3"/>
    <dbReference type="SMR" id="A0A836KBE3"/>
    <dbReference type="GeneID" id="92356094"/>
    <dbReference type="KEGG" id="loi:92356094"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23962">
        <property type="entry name" value="KREPA6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000251">
        <property type="entry name" value="MP18 RNA editing complex protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017084">
        <property type="entry name" value="RNA_edit_cplx_su_MP18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40735:SF3">
        <property type="entry name" value="RNA-EDITING COMPLEX PROTEIN MP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40735">
        <property type="entry name" value="RNA-EDITING COMPLEX PROTEIN MP42-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037000">
        <property type="entry name" value="RNA_ed_MP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5464630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="23799" checksum="A331D2B029615EEA" modified="2021-09-29" version="1">MIRRLSSVNTAPLMATTVHLLTSVKQPQSFAGTRAAVSWIATRGCSSTSSGSASSTKGAGFSAGQPGRRAPSINCVTLVGVVHDIQTGYVFEDAVTQFTLTTTSLDTAKQAHECVVEKDHHTVRCYGDVFSREVRAKLSEGNVVCVNGRLRLNPQMEPSCNKYYYFPYIQVQPPHGQVSVVYGDRRSPPSAVDAAAGELNNGSATPTSGAAPDESGGASAATQKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KBI2</accession>
    <name>A0A836KBI2_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_03039</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-ketoglutarate dehydrogenase component 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060610.1">
        <property type="nucleotide sequence ID" value="XM_067205058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KBI2"/>
    <dbReference type="GeneID" id="92358992"/>
    <dbReference type="KEGG" id="loi:92358992"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020373">
        <property type="entry name" value="Kgd4/YMR-31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10937">
        <property type="entry name" value="Kgd4-YMR31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5470344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="98" mass="10591" checksum="C80272AAA185BF4F" modified="2021-09-29" version="1">MYRQSRLFFHTPSIRFTYALAKSCGSSGALTASTEGASATAAATTTSAVDSAAKTIFESFDELPTHLRPHVFEEAEIEAIHMGGAASYVPKHLQRKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KBU1</accession>
    <name>A0A836KBU1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein FAM184A/B N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_01689</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059427.1">
        <property type="nucleotide sequence ID" value="XM_067203736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KBU1"/>
    <dbReference type="SMR" id="A0A836KBU1"/>
    <dbReference type="GeneID" id="92357670"/>
    <dbReference type="KEGG" id="loi:92357670"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18870">
        <property type="entry name" value="PROTEIN TAG-278-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18870:SF9">
        <property type="entry name" value="PROTEIN TAG-278-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="981"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="53"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="159"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="297"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="367"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="451"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="511"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="642"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="837"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="940"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="991"/>
            <end position="1001"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5466537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1014" mass="112897" checksum="E5AEE23C9EBD0765" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KCU8</accession>
    <name>A0A836KCU8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Adenylate kinase active site lid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_00770</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the adenylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059494.1">
        <property type="nucleotide sequence ID" value="XM_067202844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KCU8"/>
    <dbReference type="SMR" id="A0A836KCU8"/>
    <dbReference type="GeneID" id="92356778"/>
    <dbReference type="KEGG" id="loi:92356778"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000106">
        <property type="entry name" value="Adenylate kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001381">
        <property type="entry name" value="PRK00279.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="5">
        <location>
            <begin position="123"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5467692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="218" mass="24440" checksum="9C2ED4A7D9DD2B09" modified="2021-09-29" version="1">MKIVLMGAPGCGKGTQSPYIQDRYGLCHLSTGDMLRDAVTRKTANGQLAKTAMDSGKLVSDDIVFGIVKDGIKNPECRYGYILDGFPRTLKQAKMMEDAGEKIDKVIEFNVPDEVILERTSGRWIHKPSGRTYHEVFRPPRTPGKDDITGEDLFQRPDDRREVCERRLGIYKNETRPLADYFTKKGVYSMINANQTVDEVRKTIAALLDPIAIATGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KCY9</accession>
    <name>A0A836KCY9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">9,11-endoperoxide prostaglandin H2 reductase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Prostaglandin F2-alpha synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">LSCM4_03323</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">LSCM4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>prostaglandin F2alpha + NADP(+) = prostaglandin H2 + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45312"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57404"/>
            <dbReference type="ChEBI" id="CHEBI:57405"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; prostaglandin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060886.1">
        <property type="nucleotide sequence ID" value="XM_067205334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KCY9"/>
    <dbReference type="SMR" id="A0A836KCY9"/>
    <dbReference type="GeneID" id="92359268"/>
    <dbReference type="KEGG" id="loi:92359268"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000015">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0643">Prostaglandin biosynthesis</keyword>
    <keyword evidence="5" id="KW-0644">Prostaglandin metabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="19">
        <location>
            <begin position="30"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="16">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="18">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00067802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00079905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAG5471769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="284" mass="32158" checksum="868CD72BE03EAFC2" modified="2021-09-29" version="1">MACVGKASVTLHNGVKMPLFGLGVWQSPVGEATENAVKWALQAGYRHIDTAAIYRNEESVGAGLRASGVSREEVFITTKLWNTEQGYESTLAAFEESRKKLGVDYIDLYLIHWPRGQAIIAKDGKKYLDTWRAFEKLYEEKKVRAIGVSNFNIHHLEDVLAMCSVAPMVNQVELHPLNTQAKLRSFCEAKRIYVEAWSPLGQGKLLTDQTLVEIATKYKKTVAQVILRWDIQHGLITIPKSIHKDRIEENMNIFDFELSAEDMEKIDALNKDSRYGPEPDEADF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KD22</accession>
    <name>A0A836KD22_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_03419</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060976.1">
        <property type="nucleotide sequence ID" value="XM_067205424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KD22"/>
    <dbReference type="GeneID" id="92359358"/>
    <dbReference type="KEGG" id="loi:92359358"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="29"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="125"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5471859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="242" mass="26417" checksum="30A51F2129831B1D" modified="2021-09-29" version="1">MWRAVRRTACSVPPMTVARWRSNSDKGAASAAAYDSEEATKASLGSSASTPGEVSDSSAAQNSAKSDAYRFPANEVMDAVKKRDFNAVQTHATKLVQSQWREEFNVPAACVVIFVVMWYWIAWTRRSIRRKCEAAKASVKQQTDEMVEIVRSMTEKWKCDMAKANRQMQGIIDKNSELTRDIDRMTTALRSCSIRPTAASTAAIAPTVPMVKRVEPVDEEGAAEAAEAAAGGSCEAPASLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KE35</accession>
    <name>A0A836KE35_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA (guanine(9)-N(1))-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.221</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_02234</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>guanosine(9) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43156"/>
            <dbReference type="Rhea" id="RHEA-COMP:10367"/>
            <dbReference type="Rhea" id="RHEA-COMP:10368"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.221"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.221" evidence="1"/>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061305.1">
        <property type="nucleotide sequence ID" value="XM_067204268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KE35"/>
    <dbReference type="SMR" id="A0A836KE35"/>
    <dbReference type="GeneID" id="92358202"/>
    <dbReference type="KEGG" id="loi:92358202"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052905">
        <property type="term" value="F:tRNA (guanosine(9)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002939">
        <property type="term" value="P:tRNA N1-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18089">
        <property type="entry name" value="SPOUT_Trm10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1280.30:FF:000011">
        <property type="entry name" value="tRNA (Guanine-1)-methyltransferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028564">
        <property type="entry name" value="MT_TRM10-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038459">
        <property type="entry name" value="MT_TRM10-typ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007356">
        <property type="entry name" value="tRNA_m1G_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563">
        <property type="entry name" value="TRNA (GUANINE-9-) METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563:SF13">
        <property type="entry name" value="TRNA METHYLTRANSFERASE 10 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51675">
        <property type="entry name" value="SAM_MT_TRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase TRM10-type" evidence="7">
        <location>
            <begin position="123"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="20"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="328"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="333"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="353"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="371"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5472909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="383" mass="42425" checksum="193FC7FFAF23B79C" modified="2021-09-29" version="1">MISGLESSMAASTAVICTSSSSLTSASDAHGTSASDVRDDAAQALHKPPIEHHRQRKSWTEEEKRRYWKQKKAEKRERVKAAAAERRQTQQDLWERLSEEEKEARRSEAALLHEMRRQAEEALVRRCEAQLANPHVPAIVFDLSFAWCMTVANTKSTVSQVKLSYSALRTAGFPFRPIITSLMGKEARDTEHDATAQATALQVLDGFEGFRRFPPCVTQVQHWSELLAPSQVVFLTADSPHTLNSIDPDTAYVVGAFVDHNANKGLSFASAQRHGVRTARLPIKETVVLGNRCKVLTINHVVEVLIHYEQLRAAGTPDWSQAIENALPTRRTQQAKKRRRKRQRVGGAISGDESGDGDEGGDGGDTKDASYYESVSAAAEERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KJU0</accession>
    <name>A0A836KJU0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit G</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_04646</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase G subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000023">
        <property type="protein sequence ID" value="KAG5478414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063075.1">
        <property type="nucleotide sequence ID" value="XM_067206628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KJU0"/>
    <dbReference type="SMR" id="A0A836KJU0"/>
    <dbReference type="GeneID" id="92360562"/>
    <dbReference type="KEGG" id="loi:92360562"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.2950:FF:000004">
        <property type="entry name" value="V-type proton ATPase subunit G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005124">
        <property type="entry name" value="V-ATPase_G"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01147">
        <property type="entry name" value="V_ATP_synt_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713:SF11">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03179">
        <property type="entry name" value="V-ATPase_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="11"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5478414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="108" mass="12412" checksum="A75317387B34AD43" modified="2021-09-29" version="1">MPPKQDNVQKLLAAEEKRNKLIAEAKARKQQKVKQAKADAEREVAFFRAEKDKEYDRYRAQQNGGADAEHAELARQTDKELEELKALTTQRMDAVANMMVRLIVTVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KJV7</accession>
    <name>A0A836KJV7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_04179</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062105.1">
        <property type="nucleotide sequence ID" value="XM_067206168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KJV7"/>
    <dbReference type="SMR" id="A0A836KJV7"/>
    <dbReference type="GeneID" id="92360102"/>
    <dbReference type="KEGG" id="loi:92360102"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990275">
        <property type="term" value="F:preribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000018">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000323">
        <property type="entry name" value="Putative vesicular transport protein (CDC48 homologue)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001406">
        <property type="entry name" value="Putative vesicular transport protein (CDC48)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000110">
        <property type="entry name" value="Ribosome biogenesis ATPase RIX7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="126"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="406"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5475597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="666" mass="72703" checksum="3003876D64C79551" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KJX0</accession>
    <name>A0A836KJX0_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_04722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000023">
        <property type="protein sequence ID" value="KAG5478489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063150.1">
        <property type="nucleotide sequence ID" value="XM_067206703.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92360637"/>
    <dbReference type="KEGG" id="loi:92360637"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="646"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="761"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="855"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1188"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1280"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1354"/>
            <end position="1451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1475"/>
            <end position="1535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1581"/>
            <end position="1630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1720"/>
            <end position="1743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1802"/>
            <end position="1847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2070"/>
            <end position="2109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2208"/>
            <end position="2237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2487"/>
            <end position="2524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="488"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="655"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="775"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="797"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="828"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="855"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="884"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="924"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1508"/>
            <end position="1527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1804"/>
            <end position="1813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1823"/>
            <end position="1837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2077"/>
            <end position="2092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="2487"/>
            <end position="2496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5478489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="2865" mass="302910" checksum="36F2440FB9C6B8A9" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KMF1</accession>
    <name>A0A836KMF1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U1-C C2H2-type zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_05743</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063447.1">
        <property type="nucleotide sequence ID" value="XM_067207674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KMF1"/>
    <dbReference type="SMR" id="A0A836KMF1"/>
    <dbReference type="GeneID" id="92361608"/>
    <dbReference type="KEGG" id="loi:92361608"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013085">
        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16465">
        <property type="entry name" value="NUCLEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16465:SF0">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="U1-C C2H2-type zinc finger" evidence="5">
        <location>
            <begin position="74"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
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        <location>
            <begin position="206"/>
            <end position="237"/>
        </location>
    </feature>
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        <location>
            <begin position="206"/>
            <end position="220"/>
        </location>
    </feature>
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        <location>
            <begin position="221"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5479736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="237" mass="25854" checksum="114370A193B5DB40" modified="2021-09-29" version="1">MDPSAVAAPSTTAGISQHPHLNGSGNDALSAGQPSEAEIKRIRQRRRIASKTPEQRRKLLQYQRRHNEKDERLYYCDYCDLFVSSRHRAWMTHMRSARHMDAFQSYYELVAHVESVWVTEINREVELARSREVHRLQQMFAGKGAATPLAAQRIAPGIVVGGAPTAALARLPLQPPFTHLPRGAAQVPPAPTIRVGNKAILPRAASAASSADVASPSTDAQSSGSGVNESQLPTPQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KMF2</accession>
    <name>A0A836KMF2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nucleosome assembly protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_06427</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the nucleosome assembly protein (NAP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000019">
        <property type="protein sequence ID" value="KAG5480859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063860.1">
        <property type="nucleotide sequence ID" value="XM_067208348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KMF2"/>
    <dbReference type="SMR" id="A0A836KMF2"/>
    <dbReference type="GeneID" id="92362282"/>
    <dbReference type="KEGG" id="loi:92362282"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.90:FF:000010">
        <property type="entry name" value="Probable nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.90">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037231">
        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002164">
        <property type="entry name" value="NAP_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11875">
        <property type="entry name" value="TESTIS-SPECIFIC Y-ENCODED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00956">
        <property type="entry name" value="NAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143113">
        <property type="entry name" value="NAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="302"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="265"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5480859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="39775" checksum="7CFDB4ED06204116" modified="2021-09-29" version="1">MPPKHQREAPAMMQEDGDDDVMETGNMLDFQKYLDPDFSKNFLEGLPEKIRQRAQVLSAYDGDLTAQQKAQKAKEADILRRYDALFAPLLERRKEIVTGAAVSDEEVKKGMPEEHAEVVSVAVDDTDEAAKAADAFGLEGFWLRVLRHHTVIDSTIEPHDEDVLKHLVDIRSCIAEGDYGSFQVVFTFSPNDFFEEETITATVRVKDDESELTVTPITWKPGKNVMMHTITKKQRVKRTGQMRTVSHDVPQPSFFWLFKKKASADDEGDEEDEEDDEEQRTSMLEVLHTCIVPNAVRYYTGEAPNGFSDVDEEDEEEEEEEDEEEEEIIPRGRGGARGANRGGRGGRGGRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KMH7</accession>
    <name>A0A836KMH7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Stealth protein CR3 conserved region 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_04755</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the stealth family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000023">
        <property type="protein sequence ID" value="KAG5478522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063183.1">
        <property type="nucleotide sequence ID" value="XM_067206736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KMH7"/>
    <dbReference type="GeneID" id="92360670"/>
    <dbReference type="KEGG" id="loi:92360670"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016772">
        <property type="term" value="F:transferase activity, transferring phosphorus-containing groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047141">
        <property type="entry name" value="Stealth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021520">
        <property type="entry name" value="Stealth_CR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031357">
        <property type="entry name" value="Stealth_CR3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24045">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24045:SF0">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-1-PHOSPHOTRANSFERASE SUBUNITS ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11380">
        <property type="entry name" value="Stealth_CR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17102">
        <property type="entry name" value="Stealth_CR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Stealth protein CR2 conserved region 2" evidence="4">
        <location>
            <begin position="249"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Stealth protein CR3 conserved region 3" evidence="5">
        <location>
            <begin position="470"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="603"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="603"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5478522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="791" mass="88208" checksum="BBFC2B28EE9237D2" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KNS7</accession>
    <name>A0A836KNS7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="1">PPIase</shortName>
            <ecNumber evidence="1">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_01917</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="1"/>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060994.1">
        <property type="nucleotide sequence ID" value="XM_067203957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KNS7"/>
    <dbReference type="SMR" id="A0A836KNS7"/>
    <dbReference type="GeneID" id="92357891"/>
    <dbReference type="KEGG" id="loi:92357891"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000056">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="3">
        <location>
            <begin position="56"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5472598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="245" mass="27387" checksum="D51F8DF9F7854F5B" modified="2021-09-29" version="1">MQLRVLKPRKDAPQASPPMPSRDEVYSSIEERRLKEWENYQKAHRFMDEAHTNRIFLDIGIGDALAGRLVVELFEDLVPETAAHFRRLVTGRSGIHDATGVKLDYLYTPLELIDHQHGYARFGDLLAYGVQLEPLRQETFKVRHTTRGLLTMTSYGPHRCNTSFAITLAAAPTLDFQQVVFGKVVDGLPLLEKLESLSVDEVGRPLTPVMIALCGSLTGERPPGKWASPPGRVGDNEDNASEIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KP43</accession>
    <name>A0A836KP43_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">S-adenosylmethionine synthase</fullName>
            <ecNumber evidence="11">2.5.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LSCM4_02282</name>
        <name evidence="17" type="ORF">LSCM4_02284</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">LSCM4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of S-adenosylmethionine from methionine and ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-methionine + ATP + H2O = S-adenosyl-L-methionine + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="11">Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AdoMet synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="11"/>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061352.1">
        <property type="nucleotide sequence ID" value="XM_067204315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KP43"/>
    <dbReference type="SMR" id="A0A836KP43"/>
    <dbReference type="GeneID" id="92358249"/>
    <dbReference type="KEGG" id="loi:92358249"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18079">
        <property type="entry name" value="S-AdoMet_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000001">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000003">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000004">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="S-adenosylmethionine synthetase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-adenosylmethionine synthetase N-terminal" evidence="13">
        <location>
            <begin position="6"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase central" evidence="14">
        <location>
            <begin position="117"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase C-terminal" evidence="15">
        <location>
            <begin position="244"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG5472956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG5472958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="392" mass="43095" checksum="4E3AC38B3056F02D" modified="2021-09-29" version="1">MSVHSILFSSEHVTEGHPDKLCDQVSDAVLDACLAGDPFSKVACESCAKTGMVMVFGEITTKVVLDYQKIIRDTVKDIGFDSADKGLDYESCNVLVAIEQQSPDICQGLGNFDSEDLGAGDQGMMFGYATDETETLMPLTYELARGLAKKYSELRRDGSLEWARPDAKTQVTVEYDYDTSEGKQVLTPKRVAVVLISAQHDEHVTNDKIRVDLMEKVIKAVIPANMLDAETKYWLNPSGRFVRGGPHGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDPSKVDRSAAYAARWIAKSIVAGGLARRCLVQLAYAIGVSEPLSVHVETYGTGKYDDAKLLEIVKKNFKLRPYDIIQELSLRRPIYYETSRFGHFGRKDESGKGGFTWEVPKKIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KQD3</accession>
    <name>A0A836KQD3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Apyrase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_07170</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000015">
        <property type="protein sequence ID" value="KAG5482961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064457.1">
        <property type="nucleotide sequence ID" value="XM_067209074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KQD3"/>
    <dbReference type="SMR" id="A0A836KQD3"/>
    <dbReference type="GeneID" id="92363008"/>
    <dbReference type="KEGG" id="loi:92363008"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017110">
        <property type="term" value="F:nucleoside diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009134">
        <property type="term" value="P:nucleoside diphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782:SF83">
        <property type="entry name" value="GUANOSINE-DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01238">
        <property type="entry name" value="GDA1_CD39_NTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="201"/>
            <end position="205"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5482961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="425" mass="46294" checksum="1578F940B05AFC15" modified="2021-09-29" version="1">MPPYSSVRRMTQQSKRLRLSGALVLGALVLLGFVVYYESPSFAPCTSPYANVYDIVIDAGSTGSRVHVFRYERSSSGVVLLGEIFKRVEPALSSFAANPDGAKQSIKGLLRIAENAVPRSYQSCTSVTLKATAGLRLLSDAEQQLLINAAEQALKASPFQSRGASIISGAQEGIYGWLTVNYLLRTLDTEGATVATIDMGGASTQVVFETKYSSGEWLPFNYAHQLRTPKRTIAMYQHSYLGLGLNEAKKRLMALFAEVNGTTPFACFPRGYSKRLNGVGLQNGDATDFNVCAGLFCEHVITKPICKFDGCGARGVPQPSLSSGQYAIYAFSYFYDRLHQFRNEDSPVYVSSYKEVGQEVCARESVGRTSASEETACMELAYLYSFLTHGLGLSDDTVLTVPNHIDGKAVSWSLGSSLSFVLKME</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KQF1</accession>
    <name>A0A836KQF1_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_07232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000015">
        <property type="protein sequence ID" value="KAG5483021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064517.1">
        <property type="nucleotide sequence ID" value="XM_067209134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KQF1"/>
    <dbReference type="GeneID" id="92363068"/>
    <dbReference type="KEGG" id="loi:92363068"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="699"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="707"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="718"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="769"/>
            <end position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5483021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="780" mass="80760" checksum="589D9BA8B857584F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KRK8</accession>
    <name>A0A836KRK8_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_07847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000013">
        <property type="protein sequence ID" value="KAG5484281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064774.1">
        <property type="nucleotide sequence ID" value="XM_067209724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KRK8"/>
    <dbReference type="GeneID" id="92363658"/>
    <dbReference type="KEGG" id="loi:92363658"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5484281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="196" mass="21838" checksum="13393DA2706D0949" modified="2021-09-29" version="1">MHAAAPPAPPTPQVRYVDLLVGSSSDHELGALETIREAGQSPEAVAKAGRHGPDGTAAPRGRKLVTRVTTPERIRRTSARLYEDIHAIMDRHDARTSRELDLRRRVSRNARISYLEEQLNRPRHRATGASSSSCVEKTVLPNVHQMFDESRRAHLSEAQEQRTYFPSSSKPTTYSSKNPSTFSYRFQLHPSANGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KRW0</accession>
    <name>A0A836KRW0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1935 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000020">
        <property type="protein sequence ID" value="KAG5480440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063771.1">
        <property type="nucleotide sequence ID" value="XM_067208131.1"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A836KRW0"/>
    <dbReference type="GeneID" id="92362065"/>
    <dbReference type="KEGG" id="loi:92362065"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
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        <property type="entry name" value="Calpain-like cysteine peptidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF1935"/>
    </dbReference>
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        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036310">
        <property type="entry name" value="Smp-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47047:SF3">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47047">
        <property type="entry name" value="PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09149">
        <property type="entry name" value="DUF1935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101601">
        <property type="entry name" value="Smp-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1935" evidence="1">
        <location>
            <begin position="14"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5480440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="131" mass="15028" checksum="663C0FE3404810E2" modified="2021-09-29" version="1">MGCGASSECSNVTYVNGKPTFAGDEITKGFEKDNGLLFRIVNRKKKQWAYYNDTTQYEMHVMVTFNEDCDIKALGKTKLEQQENGEWVASVVVYPCETEMFIEGRVNGFKSKMDALPLSEEYRQRQAEKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KS82</accession>
    <name>A0A836KS82_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000019">
        <property type="protein sequence ID" value="KAG5480815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063816.1">
        <property type="nucleotide sequence ID" value="XM_067208304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KS82"/>
    <dbReference type="GeneID" id="92362238"/>
    <dbReference type="KEGG" id="loi:92362238"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5480815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="367" mass="40015" checksum="D79F4D17B8889755" modified="2021-09-29" version="1">MSAGPKPEARQAPRERNTPKPPTGNSSSAHAERPQRRRDNGERREGAERGERRDRPERQERPRRAPAGSAAAAEKSKPSIEEKAHGPVVHVKGDIASGSTWAKNGSGPSFADMVRQRTNTRADGCAAKGTPSPQKEARSQVQTPPPEPPQLPPEPVPEPEPAQPEESSDEEVVINTVQAPAVVEMEPIPEPPAPVALVIAPHYVLEIERVVSVKLPPRVTHTAETQRGLYMFSAQAGKPPTPPPTVQQHAVYRPDTTNLGTRQWSLGTDSRIQQPPQQQQAWPSASQFDYWNNASERVPASRPFMGAQAQAPYNSYPSTVPLSHQRNTGNAFPVRFRSSEVPESALRQQSAVPFNRASQPTNGGGVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KS85</accession>
    <name>A0A836KS85_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nascent polypeptide-associated complex subunit alpha-like UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_04879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000014">
        <property type="protein sequence ID" value="KAG5483727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064666.1">
        <property type="nucleotide sequence ID" value="XM_067206857.1"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A836KS85"/>
    <dbReference type="GeneID" id="92360791"/>
    <dbReference type="KEGG" id="loi:92360791"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052617">
        <property type="entry name" value="Huntingtin-int_K"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31184:SF2">
        <property type="entry name" value="HUNTINGTIN-INTERACTING PROTEIN K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31184">
        <property type="entry name" value="HUNTINGTIN-INTERACTING PROTEIN K FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5483727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="109" mass="11819" checksum="C2F6853C94F784B0" modified="2021-09-29" version="1">MSRQVDEQKSMRNVAGSGEAEKTSKLRTHDLAALQERMKKLHAEVTQQSEAKEQRARELAAVPVADADVQVVAAALAVTPECARSRLQEKSGDVMAVLRDAVGLPKVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KS97</accession>
    <name>A0A836KS97_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000019">
        <property type="protein sequence ID" value="KAG5480860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063861.1">
        <property type="nucleotide sequence ID" value="XM_067208349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KS97"/>
    <dbReference type="SMR" id="A0A836KS97"/>
    <dbReference type="GeneID" id="92362283"/>
    <dbReference type="KEGG" id="loi:92362283"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="645"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="763"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5480860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="885" mass="93689" checksum="1BA427357750387D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KT10</accession>
    <name>A0A836KT10_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_04375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062569.1">
        <property type="nucleotide sequence ID" value="XM_067206360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KT10"/>
    <dbReference type="GeneID" id="92360294"/>
    <dbReference type="KEGG" id="loi:92360294"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="CDD" id="cd11709">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050672">
        <property type="entry name" value="FBXO45-Fsn/SPSB_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245">
        <property type="entry name" value="SPRY DOMAIN CONTAINING SOCS BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245:SF5">
        <property type="entry name" value="SPRY DOMAIN-CONTAINING SOCS BOX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPRY" evidence="2">
        <location>
            <begin position="637"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5477158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="711" mass="75251" checksum="AB6E14F592351933" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KU38</accession>
    <name>A0A836KU38_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_07737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000006">
        <property type="protein sequence ID" value="KAG5487249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065746.1">
        <property type="nucleotide sequence ID" value="XM_067209616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KU38"/>
    <dbReference type="GeneID" id="92363550"/>
    <dbReference type="KEGG" id="loi:92363550"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5487249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="902" mass="97315" checksum="B70B553C23C3B878" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KUR1</accession>
    <name>A0A836KUR1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">fructose-bisphosphatase</fullName>
            <ecNumber evidence="5">3.1.3.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">D-fructose-1,6-bisphosphate 1-phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LSCM4_07575</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="3.1.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the FBPase class 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.11" evidence="5"/>
    <dbReference type="EMBL" id="JAFHLR010000004">
        <property type="protein sequence ID" value="KAG5487894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066091.1">
        <property type="nucleotide sequence ID" value="XM_067209459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KUR1"/>
    <dbReference type="SMR" id="A0A836KUR1"/>
    <dbReference type="GeneID" id="92363393"/>
    <dbReference type="KEGG" id="loi:92363393"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005986">
        <property type="term" value="P:sucrose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00354">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000001">
        <property type="entry name" value="Fructose-1,6-bisphosphatase class 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000019">
        <property type="entry name" value="Fructose-1,6-bisphosphatase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01855">
        <property type="entry name" value="FBPase_class1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044015">
        <property type="entry name" value="FBPase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000146">
        <property type="entry name" value="FBPase_class-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033391">
        <property type="entry name" value="FBPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028343">
        <property type="entry name" value="FBPtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020548">
        <property type="entry name" value="Fructose_bisphosphatase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11556">
        <property type="entry name" value="FRUCTOSE-1,6-BISPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11556:SF1">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00316">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18913">
        <property type="entry name" value="FBPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500210">
        <property type="entry name" value="FBPtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000904">
        <property type="entry name" value="FBPtase_SBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00115">
        <property type="entry name" value="F16BPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00124">
        <property type="entry name" value="FBPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fructose-1-6-bisphosphatase class I N-terminal" evidence="13">
        <location>
            <begin position="11"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Fructose-1-6-bisphosphatase class 1 C-terminal" evidence="14">
        <location>
            <begin position="208"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG5487894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="351" mass="38960" checksum="A6FAB31CCAC9E97C" modified="2021-09-29" version="1">MHTSRTLTPTTLTQYIIKSQPPQSSGDFTLLMMAIQTSVKVIEKNIRRAGMKGILGYIAGQSANATGDHQAKLDVISNMAFKAYLLSSTSVCVLGSEEEKQMIIAERGRRGDYLIFFDPLDGSSNIDANVAVGSIWGVWRLPKGTEINTVEEANAVIRTLKGTDMVSAGYAVYGSATNLVLTSGHGVDGFTLDPNIGEFILTHPHISIPKKRSIYSVNEGNYGKWEPWFREYIDYLKMNKTTRYSARYIGSMVGDIHRTLLYGGIFCYPKDANQKEGKLRFLYEAAPMAMIVEQAGGKAMGSNGRVLEQSITRLHQRTPVYFGSRQEVDLCMAFRNRNMKAKTLARLPSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KVK5</accession>
    <name>A0A836KVK5_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063434.1">
        <property type="nucleotide sequence ID" value="XM_067207661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KVK5"/>
    <dbReference type="SMR" id="A0A836KVK5"/>
    <dbReference type="GeneID" id="92361595"/>
    <dbReference type="KEGG" id="loi:92361595"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="582"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5479723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="722" mass="78850" checksum="DC4DF37FD65CB124" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KVY7</accession>
    <name>A0A836KVY7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ornithine decarboxylase</fullName>
            <ecNumber evidence="6">4.1.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LSCM4_07622</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-ornithine + H(+) = putrescine + CO2</text>
            <dbReference type="Rhea" id="RHEA:22964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="4.1.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer. Only the dimer is catalytically active, as the active sites are constructed of residues from both monomers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Orn/Lys/Arg decarboxylase class-II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.17" evidence="6"/>
    <dbReference type="EMBL" id="JAFHLR010000012">
        <property type="protein sequence ID" value="KAG5484850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064962.1">
        <property type="nucleotide sequence ID" value="XM_067209502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KVY7"/>
    <dbReference type="SMR" id="A0A836KVY7"/>
    <dbReference type="GeneID" id="92363436"/>
    <dbReference type="KEGG" id="loi:92363436"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004586">
        <property type="term" value="F:ornithine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033387">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00622">
        <property type="entry name" value="PLPDE_III_ODC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000005">
        <property type="entry name" value="Ornithine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="entry name" value="Lyase, Ornithine Decarboxylase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022657">
        <property type="entry name" value="De-COase2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002433">
        <property type="entry name" value="Orn_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482">
        <property type="entry name" value="ARGININE/DIAMINOPIMELATE/ORNITHINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482:SF6">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01182">
        <property type="entry name" value="ORNDCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="Alanine racemase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00879">
        <property type="entry name" value="ODR_DC_2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 N-terminal" evidence="12">
        <location>
            <begin position="289"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 C-terminal" evidence="11">
        <location>
            <begin position="531"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="659"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600183-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG5484850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="734" mass="80426" checksum="6A3DDFC3A0E9B2F4" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KXE4</accession>
    <name>A0A836KXE4_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_07368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000008">
        <property type="protein sequence ID" value="KAG5486440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065506.1">
        <property type="nucleotide sequence ID" value="XM_067209263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KXE4"/>
    <dbReference type="GeneID" id="92363197"/>
    <dbReference type="KEGG" id="loi:92363197"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="604"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="687"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="905"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
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        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="620"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <end position="726"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="764"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="844"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="864"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="920"/>
            <end position="933"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5486440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="959" mass="99423" checksum="CB7A97FFF28BFFF4" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KXF9</accession>
    <name>A0A836KXF9_9TRYP</name>
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        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_07417</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000008">
        <property type="protein sequence ID" value="KAG5486485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="22"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="2">
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            <end position="270"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="284"/>
            <end position="314"/>
        </location>
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            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5486485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="333" mass="37285" checksum="9A7B430C6329AB8C" modified="2021-09-29" version="1">MSEAQQAAEIARLLACEARKASPFEFLQLDIATCELNDVNRQYRRIALLLHPDKCHLSNAADAFHAAEKVHKSLSQESIFYHLKRAYQRQQDRLAEEGTSGTATASRTVPAAASSSDAGVTAGQKRAREMEAVLPPIAFGSLTQLAASGLSSEAQKAAEIRRVLQCKATDYFIILDVDPSICTVADVDRRYRKMAQALHPDKCQLPHVQDAFTVFEKAHKELADERRLIRFKVAFEQQRRKEAALMAAASQGGMRSSGGDTTSGFGPDEGMTAEERLQKRRMEALRDQQLEAARLGEEAARRRKLKEEKEREETALAAELERQRKEWNDLQLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836KYB6_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_05682</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000016">
        <property type="protein sequence ID" value="KAG5482423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064429.1">
        <property type="nucleotide sequence ID" value="XM_067207615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KYB6"/>
    <dbReference type="SMR" id="A0A836KYB6"/>
    <dbReference type="GeneID" id="92361549"/>
    <dbReference type="KEGG" id="loi:92361549"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="69"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="122"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="274"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="70"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="130"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5482423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="536" mass="57204" checksum="E561A772D3E52093" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836L1N5</accession>
    <name>A0A836L1N5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_06574</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO1/REXO3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000010">
        <property type="protein sequence ID" value="KAG5485618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065202.1">
        <property type="nucleotide sequence ID" value="XM_067208491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836L1N5"/>
    <dbReference type="SMR" id="A0A836L1N5"/>
    <dbReference type="GeneID" id="92362425"/>
    <dbReference type="KEGG" id="loi:92362425"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06145">
        <property type="entry name" value="REX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000031">
        <property type="entry name" value="RNA exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034922">
        <property type="entry name" value="REX1-like_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF115">
        <property type="entry name" value="FI18136P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="8">
        <location>
            <begin position="475"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="68"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="294"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="696"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="788"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="298"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="791"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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            <end position="2072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="2394"/>
            <end position="2407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5466062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="2466" mass="278331" checksum="809707E060FB42F5" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FVT7</accession>
    <name>A0A836FVT7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_02957</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="7">Part of the multisubunit transport protein particle (TRAPP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
            <location evidence="7">cis-Golgi network</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAPP small subunits family. TRAPPC4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060528.1">
        <property type="nucleotide sequence ID" value="XM_067204976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836FVT7"/>
    <dbReference type="SMR" id="A0A836FVT7"/>
    <dbReference type="GeneID" id="92358910"/>
    <dbReference type="KEGG" id="loi:92358910"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.70:FF:000019">
        <property type="entry name" value="Sybindin-like family, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007233">
        <property type="entry name" value="TRAPPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249:SF15">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04099">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01399">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="5 7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5470262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="149" mass="16503" checksum="D51FDF82503840F7" modified="2021-09-29" version="1">MVVHLLWIINQSGQLITKTAFTSPDNIGELGANPDMQLTLSSVLFSTCGMSQQLTPNADPLDSSCMTLVECEEHNIHVYETPTAVKFVLFSDNRTMECTKLLKELHALYAEFATKNPFHTVDDAGIGQPIRIPAFTEAIRTTVAKYQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FYR6</accession>
    <name>A0A836FYR6_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060909.1">
        <property type="nucleotide sequence ID" value="XM_067205357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836FYR6"/>
    <dbReference type="GeneID" id="92359291"/>
    <dbReference type="KEGG" id="loi:92359291"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5471792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="66" mass="6893" checksum="8F7C78BF2EA81C8C" modified="2021-09-29" version="1">MEAGIATKPANSPPSYQHTAEAKRHQRDADTTAQPIGPAAEPHQQPVACEYAGVALTEAKRAAING</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G245</accession>
    <name>A0A836G245_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="6">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LSCM4_03677</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="6"/>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061610.1">
        <property type="nucleotide sequence ID" value="XM_067205673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G245"/>
    <dbReference type="SMR" id="A0A836G245"/>
    <dbReference type="GeneID" id="92359607"/>
    <dbReference type="KEGG" id="loi:92359607"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000744">
        <property type="entry name" value="Putative mitogen activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013:SF9">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
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        <location>
            <begin position="63"/>
            <end position="319"/>
        </location>
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            <position position="91"/>
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            <dbReference type="ARBA" id="ARBA00038999"/>
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            <dbReference type="ARBA" id="ARBA00049014"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00049299"/>
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        <source>
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        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5473607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="372" mass="41502" checksum="79EAB6B7F75548DD" modified="2021-09-29" version="1">MKNRPALALDTAVVEKFQQDSKSYQINSNNSLQFRAFLFNEAGMYTKDGRELPSTVKKDDIDYSSKRNVGAGASGDVFFARLKKGTSIALKRIPISSKTHRDEVDRELQVFMARGDSPYVMNNYGAFWDAEDDAIVIPMEWMPYTVKDLGLFWGGLNEPLLKAVFFQVVSGLVYLHDVKRVLHRDLKPSNLLISESGHVKIADFGVSKLIQTLAVSSTYVGTMCFMAPERLEQGMYGFSSDVWSLGLTMIGAVTGKNPWAPPEEMNLYQLLGKMANGSTPSLPMSSAFSDDANDFVQQCLKRDPDTRPTCAELLQHRFFAGVTTESAVAMVKMAVEQMTRLINNNAQKEKEVARTQESLEKDVKAQIDKMVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G253</accession>
    <name>A0A836G253_9TRYP</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    <gene>
        <name evidence="2" type="ORF">LSCM4_03692</name>
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    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061625.1">
        <property type="nucleotide sequence ID" value="XM_067205688.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="92359622"/>
    <dbReference type="KEGG" id="loi:92359622"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="106"/>
        </location>
    </feature>
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            <end position="708"/>
        </location>
    </feature>
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            <begin position="895"/>
            <end position="922"/>
        </location>
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        <location>
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            <begin position="84"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <end position="223"/>
        </location>
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        </location>
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            <begin position="607"/>
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        </location>
    </feature>
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            <begin position="947"/>
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        <location>
            <begin position="976"/>
            <end position="988"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5473622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1017" mass="106942" checksum="C965F9619CE2CC18" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G4Z5</accession>
    <name>A0A836G4Z5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LSCM4_01560</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I NDUFB7 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059299.1">
        <property type="nucleotide sequence ID" value="XM_067203608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G4Z5"/>
    <dbReference type="SMR" id="A0A836G4Z5"/>
    <dbReference type="GeneID" id="92357542"/>
    <dbReference type="KEGG" id="loi:92357542"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008698">
        <property type="entry name" value="NDUB7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900">
        <property type="entry name" value="NADH:UBIQUINONE OXIDOREDUCTASE B18-LIKE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05676">
        <property type="entry name" value="NDUF_B7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018677"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG5466409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="225" mass="26457" checksum="C635183F481988B3" modified="2021-09-29" version="1">MTEYLKGLASAKPGEPMPPINLGPYDNPLLWNKLDPFGADRGHQRRPMTVSRDFMELNQVPIVYRDHCVHRWIPFNRCMRNLKPVTWGTVNCHEFEEAWMVCRAHETYRLQLLKSKFMELTKDYTAEDKKFFPSILYLGIPYYMPSYYWNLATSQRLSGWDEKDPANPVMWREPNRSLMRSEFSPTNWEKGTMTSAYGHKLIPDEIVHDMVPGFPLPEEKRPQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G6P7</accession>
    <name>A0A836G6P7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Yip1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_05227</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476247.1"/>
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    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Yip1/4-like"/>
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    </dbReference>
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        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
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        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="484"/>
            <end position="504"/>
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    </feature>
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        <location>
            <begin position="516"/>
            <end position="533"/>
        </location>
    </feature>
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            <begin position="1"/>
            <end position="45"/>
        </location>
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            <end position="144"/>
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            <begin position="158"/>
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            <begin position="291"/>
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        <location>
            <begin position="332"/>
            <end position="352"/>
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        <location>
            <begin position="184"/>
            <end position="196"/>
        </location>
    </feature>
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            <begin position="219"/>
            <end position="239"/>
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        <location>
            <begin position="240"/>
            <end position="255"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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            <dbReference type="EMBL" id="KAG5476247.1"/>
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        </source>
    </evidence>
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        <source>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G896</accession>
    <name>A0A836G896_9TRYP</name>
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        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">LSCM4_02684</name>
    </gene>
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        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Discoba</taxon>
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            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG5469996.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067204710.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="loi:92358644"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="1091"/>
            <end position="1468"/>
        </location>
    </feature>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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        <location>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5469996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="2107" mass="229435" checksum="E9275803F3D2B391" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G9I6</accession>
    <name>A0A836G9I6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription activator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_02490</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="SMR" id="A0A836G9I6"/>
    <dbReference type="GeneID" id="92358453"/>
    <dbReference type="KEGG" id="loi:92358453"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chromatin remodeling protein"/>
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    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000082">
        <property type="entry name" value="ISWI chromatin remodeling complex ATPase ISW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.30">
        <property type="entry name" value="ISWI, HAND domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015194">
        <property type="entry name" value="ISWI_HAND-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036306">
        <property type="entry name" value="ISWI_HAND-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015195">
        <property type="entry name" value="SLIDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF49">
        <property type="entry name" value="SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09110">
        <property type="entry name" value="HAND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09111">
        <property type="entry name" value="SLIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101224">
        <property type="entry name" value="HAND domain of the nucleosome remodeling ATPase ISWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="178"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="475"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="872"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="872"/>
            <end position="884"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5469094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1103" mass="125794" checksum="819C33250F1409CD" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GB20</accession>
    <name>A0A836GB20_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_03150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067205166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GB20"/>
    <dbReference type="GeneID" id="92359100"/>
    <dbReference type="KEGG" id="loi:92359100"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="288"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="475"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="786"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="897"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="662"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="311"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="526"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="561"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5471601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1161" mass="123278" checksum="1748BF662A775025" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GB95</accession>
    <name>A0A836GB95_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cullin family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_03273</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">LSCM4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060838.1">
        <property type="nucleotide sequence ID" value="XM_067205286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GB95"/>
    <dbReference type="GeneID" id="92359220"/>
    <dbReference type="KEGG" id="loi:92359220"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cullin family profile" evidence="3">
        <location>
            <begin position="783"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="729"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="756"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5471721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1183" mass="129080" checksum="2FC06C88F41A396B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GBA5</accession>
    <name>A0A836GBA5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3'-5' exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_02868</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060440.1">
        <property type="nucleotide sequence ID" value="XM_067204888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GBA5"/>
    <dbReference type="SMR" id="A0A836GBA5"/>
    <dbReference type="GeneID" id="92358822"/>
    <dbReference type="KEGG" id="loi:92358822"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46814">
        <property type="entry name" value="EGALITARIAN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46814:SF1">
        <property type="entry name" value="EGALITARIAN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="2">
        <location>
            <begin position="533"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="297"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5470174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="748" mass="78838" checksum="679DF08EA2138843" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GBA6</accession>
    <name>A0A836GBA6_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_03288</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG5471736.1"/>
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    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="loi:92359235"/>
    <dbReference type="Proteomes" id="UP000674143">
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
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        <location>
            <begin position="113"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5471736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="386" mass="41955" checksum="E0061EB56A12D75C" modified="2021-09-29" version="1">MIDVRLAFIICVVICSVGFLSLVILFALRVCQPGCFLLGSPWDVDEVPVMPATVLVNRVNDDDPHTLASVIATTHTNHPAAARRERRPEQLGMREHSGVAALYDSYSNPYAARAAAAHPPSTSEAEHGAQHDGGDALPEVHSATSHYSRHQHNSPPRSHRSTSTRTTGSERSFRPHHSSNRGQGHGLYDSIEGSSDAGTPSGPRQADSASMLPSHSRSRGRGARYPIARDVRPLAFSSANPLTSRALMRNNSNSVVRLASAAPRYYAHDERSFVSPIPRGSAEDAQGSRRSRLWQWRRRNDMARETCPQNIQGARAVVDGYCCDMYGNRVRGEDAENVYGRAQYISRGLGTTSGAAAPSKESEADDASFSLFCEVEPRSSGHDPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GDL4</accession>
    <name>A0A836GDL4_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060465.1">
        <property type="nucleotide sequence ID" value="XM_067204913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GDL4"/>
    <dbReference type="GeneID" id="92358847"/>
    <dbReference type="KEGG" id="loi:92358847"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="283"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="527"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5470199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="871" mass="95723" checksum="7CD658D22E3B5D16" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GDU2</accession>
    <name>A0A836GDU2_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060776.1">
        <property type="nucleotide sequence ID" value="XM_067205224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GDU2"/>
    <dbReference type="GeneID" id="92359158"/>
    <dbReference type="KEGG" id="loi:92359158"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="624"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="681"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="629"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5471659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="875" mass="95992" checksum="A97637AEF1C6063D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GF57</accession>
    <name>A0A836GF57_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_01453</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059197.1">
        <property type="nucleotide sequence ID" value="XM_067203506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GF57"/>
    <dbReference type="SMR" id="A0A836GF57"/>
    <dbReference type="GeneID" id="92357440"/>
    <dbReference type="KEGG" id="loi:92357440"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15845">
        <property type="entry name" value="SNARE_syntaxin16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF402">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="3">
        <location>
            <begin position="207"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5466307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="302" mass="35528" checksum="3F6EC241BD427318" modified="2021-09-29" version="1">MATRDRTGEFLQYRAVRPRRPETEQLLAEEENMNRVYVTPLWVKKMADVRRIEDQIKEKMKALEKLRKDHLKVEFSSTRDEGREEAEIEEVQDTIDHLFKQSEIGVKDLEISYTRDLPDGGTDAELSILRNVKMCLVNEINNISKLYRESQRRYMMDVKKQQLVSQRWAGGDRQKTVEQQLENDALMDQYLQKGMTQEQVETIMLNQQMADERVKEFERIYTSIKSLHEMFKDMNTLVIEQGALLDRIDYNMTITHTRVQKARTELQRAAEYQAAGTYKLCVLFMIVLIIGLTIALFFKAVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GG52</accession>
    <name>A0A836GG52_9TRYP</name>
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            <fullName evidence="4">GPI transamidase component Tta2</fullName>
        </recommendedName>
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        <name evidence="2" type="ORF">LSCM4_00065</name>
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        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464625.1"/>
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            <begin position="22"/>
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            <begin position="176"/>
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        </location>
    </feature>
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            <begin position="220"/>
            <end position="243"/>
        </location>
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            <begin position="255"/>
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            <begin position="444"/>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5464625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="494" mass="54538" checksum="A235C2AB5A71E382" modified="2021-09-29" version="1">MVKATAVRTAAPPPPRMSVERLLLNPFVVFLVTFLFRAALFKFRYSVEPYIASPIIPHPSLEEVVGKNAAGAWHGGARSAYVSGVGSHVEQLVTPPPVHFCMSISITEAPTWREVVYWRERGFAEETPYYLQALAPWYVRFIPAALAKPPVTGLVLGVMDGLTAALISRWSSANAALLYTFFVLNPIMAFTTASESLTSFEFLLMTITVELCARRATSALMHAGALISAFSLGSHFLAVPVVLLSPLGTQSYRVAFAAAAMLAAGVGAYAVLYMYSVEVSHRFASLYAPPDNGVMWYVRQLVLPSFEHCLELFMLQLASMLLIPASVALPAVYVRQPSPSAAHPHLFTDGRVFFVLMAEGLSVLFRTQLTLPYCFIVVLHFYSSINPAATKTMTLEDQRVVTYSPYTRVRLLVPIMIQMTSIPLEVSFYAGWVLRETANANWKFFSDLAFVVGATAFFLLWYTEVVEDAIMCEKDSGASEAVCHASPRIHKKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GIF0</accession>
    <name>A0A836GIF0_9TRYP</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">LSCM4_04233</name>
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    <organism evidence="2 3">
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475651.1"/>
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    </dbReference>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5475651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="432" mass="46873" checksum="94B419C0ABF07AE0" modified="2021-09-29" version="1">MLRRVPRSLARRKHGQTTWSPNNTSSGAAPTNGVTAQEALQIAYRPMPLANTVEYEEDFGPNMMIHREFVSSKHRTRMASDISALAYSDVELARARQQLAGVMNRERRGALVGSGGGADDRVLFSSDVDETTREVKSARFLFNEQRMRFCDRFQTFFRERIERRVGGGDAGEDRHFYFSLMEACAVLHGCGTADAREAYYRRFLGLDLETLEAEAAAVRARAADAAEVSAQLTPKEAGAGDGALVAAAACAAGGPRSAVDAVQDIIDALPPLFPLPPAAEEGETGDAGPDARPAHVLTAGVEALPPAAAPAHIAEDAAPLYKAYLAHARGESPVASYDVATLGSHAAHAERRRWRSLMDKIAAEDYHELTAAELEDAYVLNGQLHTVKFFDLKVGDTVREIMQLLERETGSSASGDRDMPVEMSPTHPERRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GJ64</accession>
    <name>A0A836GJ64_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_03879</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
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        <lineage>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067205873.1"/>
    </dbReference>
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    <dbReference type="GO" id="GO:0008270">
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="entry name" value="Znf_RING"/>
    </dbReference>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="230"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="29"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5474704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="358" mass="41422" checksum="2017B77508060D96" modified="2021-09-29" version="1">MDQEMNDAEVVVIPDAAQLMHSKRLQCLADQLESSLAALRSMLDCLQKRMQNAGRGALLPFQLRRAKKEKEELEREIKATKHTIKKLVLMSTQMTQMIELKNKVLESTRKRFLEEIAGLKQQVSDNSKQIHRGYAQRINLLERYWPWRQLRELGDTTVGATFEEELTRGPRFRHIGIQNNIQSDYILQQLHWLQELCSHEDVFRGHMRHLEDMVEDLNDITELLETTMTCTVCGMLYERPVLLWPCGHSFCLACFDCLSIAPSLYRCPTCGSIGSEGFLHNLLLAETVAKWMFKDRGYGDTQTPINAIRAHLPRFRRDQIQSRISHLKSELLNSHGNTSSTGMDAAERERITISYRLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GL16</accession>
    <name>A0A836GL16_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Heat shock protein DNAJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_04324</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062247.1">
        <property type="nucleotide sequence ID" value="XM_067206310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GL16"/>
    <dbReference type="SMR" id="A0A836GL16"/>
    <dbReference type="GeneID" id="92360244"/>
    <dbReference type="KEGG" id="loi:92360244"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000033">
        <property type="entry name" value="DnaJ family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000074">
        <property type="entry name" value="Heat shock protein DNAJ, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="6"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="8">
        <location>
            <begin position="120"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="5">
        <location>
            <begin position="120"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="372"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5475739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="396" mass="43294" checksum="730C2B8451F5CAAD" modified="2021-09-29" version="1">MVKETGYYTALGVSPDAGEDEIKRAYRKLALKYHPDKNTEPGAQEKFKEVSVAYECLSDPEKRKRYDQFGKDAVEMQSGGVDPSDIFASFFGGGGRPRGEPKPKDIVHELPVPLEAFYCGKTIKLAITRDRLCTQCSGTGSKVAGVSATCKDCGGRGVRMVTRQLQPGFIQQIQTACPACKGKGTNLREEDKCLSCRGQQILKDKKVFEVVVEKGMHRGDSVTFSGEGDQIPGVKLSGDIIIILDQKPHPNFVRKGNHLLMEHTISLAEALTGFSLNVTQLDGRELAVSSAAGTVIDPAVMYSVSREGMPVPHTGGMERGDLIVRFRVVFPKTLRQTAAPELRKILGYPQQPPAKEGAESYTLQESLVDLEKEARRNAYDDDGDQPRVQTAGCAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GLA9</accession>
    <name>A0A836GLA9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tubulin gamma chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LSCM4_04444</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">LSCM4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers. Gamma-tubulin is a key component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation. The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062637.1">
        <property type="nucleotide sequence ID" value="XM_067206428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GLA9"/>
    <dbReference type="GeneID" id="92360362"/>
    <dbReference type="KEGG" id="loi:92360362"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02188">
        <property type="entry name" value="gamma_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000004">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000018">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002454">
        <property type="entry name" value="Gamma_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01164">
        <property type="entry name" value="GAMMATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 10" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="11">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="12">
        <location>
            <begin position="170"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG5477226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="366" mass="40904" checksum="2844B8745B454D91" modified="2021-09-29" version="1">MQKLFNTENIFIHKEGGGAGNNWSHGYELGDQVQETLFDMIEREAENSDSLEGFVLTHSIAGGTGSGMGSYLLENLNDKFPKKLIQTYSVFPNQSRGGESDVIVQPYNSLLAMKRLTLHADCVVVLDNTALNRIVTDNLHIASPTVEQMNGLVSTVMAASTATLRYPGYMNNDLMSMLASLIPTPRCHFVCTGYTPTTLDTSNIQSSVRKTSVHDVMRRLLMPKNMMVSTSMKSGCYISLLNLIQGDVDPAQVHRSLERIRERSPTFIPWGPASIQVILSKKSPYVDTRHRVSGLVMANHTSIHTLFHRTLKQFDTLFGRGVFLDQYRKYGPTKDNLDEFGDARDVVESLVAEYKACESSDYIRNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GLT0</accession>
    <name>A0A836GLT0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_05103</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062377.1">
        <property type="nucleotide sequence ID" value="XM_067207074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GLT0"/>
    <dbReference type="SMR" id="A0A836GLT0"/>
    <dbReference type="GeneID" id="92361008"/>
    <dbReference type="KEGG" id="loi:92361008"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000228">
        <property type="entry name" value="Chaperone protein DNAJ, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052423">
        <property type="entry name" value="EMIR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44094">
        <property type="entry name" value="DNAJ HEAT SHOCK N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44094:SF7">
        <property type="entry name" value="PROTEIN DNAJ, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="281"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5476144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="644" mass="70203" checksum="957DF975A822044F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GM86</accession>
    <name>A0A836GM86_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL15/eL18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_01579</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059318.1">
        <property type="nucleotide sequence ID" value="XM_067203627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GM86"/>
    <dbReference type="SMR" id="A0A836GM86"/>
    <dbReference type="GeneID" id="92357561"/>
    <dbReference type="KEGG" id="loi:92357561"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.100.10.10:FF:000015">
        <property type="entry name" value="60S ribosomal protein L27A/L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_uL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_uL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="4">
        <location>
            <begin position="72"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5466428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="145" mass="16071" checksum="7E7D69EFEBCF854A" modified="2021-09-29" version="1">MPTRFKKCRHQRGSTFCGYGRVGKHRKHESGRGNAGGMHHHRINFDKYHPGYFGKLGMDHYHRKKNPAWKPTINLNNLTRLIAADEAARATRGGSLPVVDLQSCGYAKLLGNGHIQAPCIVTARYVSKLADKKIRKAGGAVVLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GP26</accession>
    <name>A0A836GP26_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LSCM4_02522</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060102.1">
        <property type="nucleotide sequence ID" value="XM_067204550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GP26"/>
    <dbReference type="SMR" id="A0A836GP26"/>
    <dbReference type="GeneID" id="92358484"/>
    <dbReference type="KEGG" id="loi:92358484"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08215">
        <property type="entry name" value="STKc_Nek"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000535">
        <property type="entry name" value="Serine/threonine-protein kinase a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051131">
        <property type="entry name" value="NEK_Ser/Thr_kinase_NIMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899">
        <property type="entry name" value="CAMK FAMILY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="40"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="11">
        <location>
            <begin position="355"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG5469125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="452" mass="50827" checksum="6841C75AFEE481C4" modified="2021-09-29" version="1">MEARVAEVIPISSQQDPDSGAADLQFQDILGPMGSKACKYENVRELGSGSFGKALLVRRVSDGQLLVAKRMDLTAMSEKDKKYATAEIQCLASCDHFAIIKYYEDYVVEPFVLIIMEFADAGDLNMQIKQRAKDGFAYFEEHEIGYTFVQLAMAVDHIHRRRMLHRDIKGANVMLMTNGVIKLGDFGFSRQYESTVSDQVAQTFCGTPYYLAPEQWNHQRYNKKADVWAMGILLFEMMALRRPFVGQGMRALSEAVMNNKRDCELPQHYSRSLRDLCNIMLQADPSQRPSCAQLFKLPHMMKLLLDFGMSVDNSQLVSDTLKRKIHGNIFEVCDANAKGPGAFTFAGHAGTVCLSVFYEGYVRKESGRTWKERFLVLRDGGLVISRHKGDKETKPLPVSFINSAVFVPEHSACSPGVFAINLTDTKTMWFQALPPETAEAWVHKIQQSIGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GPZ5</accession>
    <name>A0A836GPZ5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_06733</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000009">
        <property type="protein sequence ID" value="KAG5486027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065358.1">
        <property type="nucleotide sequence ID" value="XM_067208647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GPZ5"/>
    <dbReference type="SMR" id="A0A836GPZ5"/>
    <dbReference type="GeneID" id="92362581"/>
    <dbReference type="KEGG" id="loi:92362581"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14134">
        <property type="entry name" value="PKc_CLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF20">
        <property type="entry name" value="KINASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="140"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="67"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5486027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="476" mass="54155" checksum="7D2702899670D10C" modified="2021-09-29" version="1">MTSLNSRLAPVTNINNNAYTTTAGAPILRKPETVSAAPAVYASSREVPLLNAQGASSSKAVAAAAATVSNRSEEATGRRSGSKRDHETSTKTDQNPLEAPRATPPPKKKKVTYTLPHQNMEEGHFYVVLGEDIDVSTQRFKILSLLGEGTFGKVVESWDRKRKEYCAVKIVRNVPKYTRDAKIEIQFMEKVRQADPADRFPLMKIQRYFQNDSGHMCIVMPKYGPCLLDWIMKHGPFNHRHLAQIVFQTGVALDYFHSELHLMHTDLKPENILMETSDSTVDPVTNRQLPPDPCRVRICDLGGCCDERHSRTAIVSTRHYRSPEVILGLGWMYSTDMWSMGCIVYELYTGKLLYDTHDNLEHLHLMEKTLGRLPSEWASRCGTEEARLLYNSTGQLRPCTDPKHLARIARARPVRDVIRDDLLCDLIYGLLHYDRQKRLNARQMTTHPYVLKYYPEARHAPSYPDNRPMLRPPPIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GQK4</accession>
    <name>A0A836GQK4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Leucine-rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_02683</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5469995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060261.1">
        <property type="nucleotide sequence ID" value="XM_067204709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GQK4"/>
    <dbReference type="GeneID" id="92358643"/>
    <dbReference type="KEGG" id="loi:92358643"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="703"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="739"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="814"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="881"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="929"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="626"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5469995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1061" mass="114116" checksum="5247A7259B5240D5" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GQS5</accession>
    <name>A0A836GQS5_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_02794</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG5470100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="KEGG" id="loi:92358748"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="631"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="723"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="135"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="631"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="755"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="779"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5470100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="800" mass="88651" checksum="257FF0EA79DDD038" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GR01</accession>
    <name>A0A836GR01_9TRYP</name>
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        <recommendedName>
            <fullName evidence="2">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_04702</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
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            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000023">
        <property type="protein sequence ID" value="KAG5478469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063130.1">
        <property type="nucleotide sequence ID" value="XM_067206683.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="92360617"/>
    <dbReference type="KEGG" id="loi:92360617"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11649:SF77">
        <property type="entry name" value="G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11649">
        <property type="entry name" value="MSS1/TRME-RELATED GTP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="2">
        <location>
            <begin position="273"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5478469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="525" mass="57800" checksum="156BD052555A96A9" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GSB3</accession>
    <name>A0A836GSB3_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Trypanosomatida</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG5480436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067208127.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="92362061"/>
    <dbReference type="KEGG" id="loi:92362061"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="686"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="800"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="806"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5480436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="833" mass="86252" checksum="31C1347555DE1AAE" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GTB4</accession>
    <name>A0A836GTB4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GRAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_07475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000004">
        <property type="protein sequence ID" value="KAG5487797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065994.1">
        <property type="nucleotide sequence ID" value="XM_067209362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GTB4"/>
    <dbReference type="SMR" id="A0A836GTB4"/>
    <dbReference type="GeneID" id="92363296"/>
    <dbReference type="KEGG" id="loi:92363296"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRAM" evidence="2">
        <location>
            <begin position="101"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5487797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="290" mass="31819" checksum="EB859C2F019E976F" modified="2021-09-29" version="1">MQNMYVQLIPLTFSGPVPAPAPACTDPTPDEQHRQAVAQKKEALNKKEARQQKTSAGSGEMFANFKKAVSQAVISIERSATDVSTRTEAQVRQLEYQHDCDRFRLHFQDLADQGEVLLADYRCSAMHGGNAVSGHLQITRRYLCFFAETSSSIAKTTDAVMGAFAAARQAASATASAPANVDRRQRLVGIREVILLAEIASIQPSVVLDTVGGYPPFFLQLPASTVCATALQVYTKDHKLYQFMSFESLISRASGALSDYKGTALECAYNYLDHAWRESVKVPLKDVEYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GTR7</accession>
    <name>A0A836GTR7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thiolase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_03256</name>
        <name evidence="5" type="ORF">LSCM4_03257</name>
        <name evidence="6" type="ORF">LSCM4_03259</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">LSCM4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060821.1">
        <property type="nucleotide sequence ID" value="XM_067205269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GTR7"/>
    <dbReference type="GeneID" id="92359203"/>
    <dbReference type="KEGG" id="loi:92359203"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050521">
        <property type="entry name" value="3-ketoacyl-CoA_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42689">
        <property type="entry name" value="ACETYL-COA ACYLTRANSFERASE FADA2 (3-KETOACYL-COA THIOLASE) (BETA-KETOTHIOLASE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42689:SF1">
        <property type="entry name" value="ACETYL-COA ACYLTRANSFERASE FADA2 (3-KETOACYL-COA THIOLASE) (BETA-KETOTHIOLASE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="3">
        <location>
            <begin position="120"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5471704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5471705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5471707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="21990" checksum="3D4A692DAAF4965C" modified="2021-09-29" version="1">MGWHGDVIGELNSISREDQEALAVASHANAARAEKAGYFSDEIVPVMVDATKNIEVKCDDVLQRDTEKMKAKMPSLKPVFRKDKGTITAATSSALTDGGSAMLVMSEEKAKKLGYPTDVSVKSWYFCGIDPYPQLLLAPVLGWGPALRKAGLAPKDIDLYEIHEAFAAQVLATIKRLRSQEFFDRYAGGGKPLSRKTLTGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GV09</accession>
    <name>A0A836GV09_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit C N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_00750</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058926.1">
        <property type="nucleotide sequence ID" value="XM_067202825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GV09"/>
    <dbReference type="SMR" id="A0A836GV09"/>
    <dbReference type="GeneID" id="92356759"/>
    <dbReference type="KEGG" id="loi:92356759"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027516">
        <property type="entry name" value="EIF3C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008905">
        <property type="entry name" value="EIF3C_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13937">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITATION FACTOR 3, SUBUNIT 8 EIF3S8 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13937:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="eIF-3c_N"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Eukaryotic translation initiation factor 3 subunit C N-terminal" evidence="5">
        <location>
            <begin position="266"/>
            <end position="526"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="21"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="698"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="702"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5465295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="731" mass="81796" checksum="A685D6335289742F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GVB2</accession>
    <name>A0A836GVB2_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">LSCM4_03745</name>
    </gene>
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        <name type="scientific">Leishmania orientalis</name>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061678.1">
        <property type="nucleotide sequence ID" value="XM_067205741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GVB2"/>
    <dbReference type="GeneID" id="92359675"/>
    <dbReference type="KEGG" id="loi:92359675"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5474572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="77" mass="9132" checksum="8968CE3C84E7FA49" modified="2021-09-29" version="1">MKEPYRSTWRVYLPGLFVMSVFSIVVYFSRTRSNAVKYGYDFVPIYSEDGKLEGFTHPVLVKAGNQYRETEEQRKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GW45</accession>
    <name>A0A836GW45_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000016">
        <property type="protein sequence ID" value="KAG5482386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064392.1">
        <property type="nucleotide sequence ID" value="XM_067207578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GW45"/>
    <dbReference type="GeneID" id="92361512"/>
    <dbReference type="KEGG" id="loi:92361512"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5482386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="332" mass="36009" checksum="5755D12838F8B8CF" modified="2021-09-29" version="1">MQRPRVMGNLGGQTTKKTYVTTYTTDVDPRTLPDFETRGVVPAEGWRGDGAPNKRGASARCSPSRAHDKQRHHHPPRLSYGQLPSHHSGAPPPGVGYHQYPHNSYHGEHSYKKASVPTSSPNTSVITSAPSTDRGSSHRLRKKYTTTTVTTITTTTILLPKMQEAYLFPPVTSHQVNQQHSAGGGGLPYAITGGHTHDDATPPQRCLQGISDGSGTGGRLQEANITNGDRVVPSKPQRRANGEASQAWEFRQHTTNNVAMESRGRLPTLEDLGITSYFARDGARNGGAAPRRRESPYAPASNSLSNGGTPLRQQPWVAGETRCEVEGGKRHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GWG3</accession>
    <name>A0A836GWG3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_01511</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000674143">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha"/>
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        <location>
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            <end position="563"/>
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            <end position="203"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="663" mass="73415" checksum="1EDE628E99A8AA60" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GY14</accession>
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        <name type="scientific">Leishmania orientalis</name>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
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        <location>
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            <begin position="391"/>
            <end position="400"/>
        </location>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5466318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="400" mass="43652" checksum="332C2AC808D7A687" modified="2021-09-29" version="1">MDRVSMGTAAVSGLRACLAWAGVIVLFSLLGSTAVNADVETPWYRINYNTPGYVLYKPQDVAQYATSRTAANGYCVQNGMSIFSAELPAKDDNFASDVAKELGGTGYFTYTGSSAEPVPTFAGQCKERQPVESALPHSGKCGFTFRFGLLTITDTILLGYQPGVAQYYSLYPGLWGAGNANTGYPVEWDTTNPNPRGYYFMAVKGLTETTGRHVNVDATVSSTDPYVTVSKFAIYCESQSFLGYLPVPTVLVQPRFVKGYKDLTWAQEHWWVIFLIVATVILIVLMVVMIYCCVTMAPPKEEPPIAPMVLREREGFAYVNALDDEASPKSRTVSTAASQHRSMPMNLHHECEILPVSGPVVDPEDLIQARPSIYVQEETALTADADSVASENEDDEPAGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GYA4</accession>
    <name>A0A836GYA4_9TRYP</name>
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            <fullName evidence="1">Non-canonical E2 ubiquitin-conjugating enzyme C-terminal domain-containing protein</fullName>
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        <name evidence="2" type="ORF">LSCM4_01619</name>
    </gene>
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        <name type="scientific">Leishmania orientalis</name>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="E2_Ub-conjug_enz_C"/>
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            <end position="488"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5466468.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="492" mass="56449" checksum="2849E5CDB9A85DC1" modified="2021-09-29" version="1">MGSLVMGRCRRGAEETYEFRDEYALLDAPIANAEHIPLRLSPKERKIQRLMRGVILASSYTDKVDSVSALKLKNRELLIVKELTNALTGLIVGLDMRKAGRFMRDHEFAPYEEEIRTAIEMCRRYKMMNPDLLRTDYVKFLYMIQDAVQSDLAHEALGFNVVKELVTVGRYCETHSIQDILQDARLPLCITPVPVMKDRNTLNRCLRGKDVVVGKLVKQYASEHHLQEDTVEVVVRSLNDANCFSNDNVETSEQLLKLLKKHFAPNSCTELTSLAIDEGADGSRLTHNHKMQYIFVLQSLSLWKNMCRKMYVLWSIAEEDMLNPNEKYELRMTGQGLQRVQKAPKLYKAIQQVLQETKEELGEWVGSERIHLGDDQVPNAFYFIDKYGQVSRIIIPILRTLDHIDHLERHAEHAAYLREVWGGGEQAKRAILRDFFRHGFDGSGGDNMDDAGSCIDGRLTSAWNWCNNIRLKAFYPLFLFSGFSSFDGDMSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H0C0</accession>
    <name>A0A836H0C0_9TRYP</name>
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        <recommendedName>
            <fullName evidence="5">Paraflagellar rod protein 2C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_05683</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Trypanosomatida</taxon>
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            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
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    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000016">
        <property type="protein sequence ID" value="KAG5482424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064430.1">
        <property type="nucleotide sequence ID" value="XM_067207616.1"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A836H0C0"/>
    <dbReference type="GeneID" id="92361550"/>
    <dbReference type="KEGG" id="loi:92361550"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007824">
        <property type="entry name" value="Flagellar_rod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053120">
        <property type="entry name" value="PFR_Component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34732:SF1">
        <property type="entry name" value="69 KDA PARAFLAGELLAR ROD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34732">
        <property type="entry name" value="69 KDA PARAFLAGELLAR ROD PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05149">
        <property type="entry name" value="Flagellar_rod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="581"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="488"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="653"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="675"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5482424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="825" mass="91725" checksum="38F461CE35C51F73" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H3X7</accession>
    <name>A0A836H3X7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_04367</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">LSCM4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
            <location evidence="2 10">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the dynein light chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062561.1">
        <property type="nucleotide sequence ID" value="XM_067206352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H3X7"/>
    <dbReference type="SMR" id="A0A836H3X7"/>
    <dbReference type="GeneID" id="92360286"/>
    <dbReference type="KEGG" id="loi:92360286"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21452">
        <property type="entry name" value="DLC-like_DYNLL1_DYNLL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.740.10:FF:000005">
        <property type="entry name" value="Dynein light chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886:SF40">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0243">Dynein</keyword>
    <keyword evidence="5 10" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5477150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="89" mass="10255" checksum="604B35076F4C647B" modified="2021-09-29" version="1">MSERKPDIKVADISPEMQADALDIASKAIKGHQLEKDMAAHIKREFDKRHFPTWHCIVGRNFGADVEHETKNFIYLYVGQMSVLLWKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H4H6</accession>
    <name>A0A836H4H6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_06642</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000010">
        <property type="protein sequence ID" value="KAG5485684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065268.1">
        <property type="nucleotide sequence ID" value="XM_067208557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H4H6"/>
    <dbReference type="SMR" id="A0A836H4H6"/>
    <dbReference type="GeneID" id="92362491"/>
    <dbReference type="KEGG" id="loi:92362491"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10470:FF:000027">
        <property type="entry name" value="Putative translation initiation factor eif-2b beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051855">
        <property type="entry name" value="eIF2B_beta_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="150"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="163"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5485684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="533" mass="57556" checksum="75AF872A58EC8B3A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H555</accession>
    <name>A0A836H555_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="10">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LSCM4_06766</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the E3 ubiquitin-protein ligase UBR1-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="10"/>
    <dbReference type="EMBL" id="JAFHLR010000009">
        <property type="protein sequence ID" value="KAG5486059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065390.1">
        <property type="nucleotide sequence ID" value="XM_067208679.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836H555"/>
    <dbReference type="GeneID" id="92362613"/>
    <dbReference type="KEGG" id="loi:92362613"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071596">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the N-end rule pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd19672">
        <property type="entry name" value="UBR-box_UBR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.30:FF:000002">
        <property type="entry name" value="Putative e3 ubiquitin-protein ligase ubr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044046">
        <property type="entry name" value="E3_ligase_UBR-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039164">
        <property type="entry name" value="UBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497:SF24">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497">
        <property type="entry name" value="UBIQUITIN LIGASE E3 ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18995">
        <property type="entry name" value="PRT6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="12">
        <location>
            <begin position="156"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="9">
        <location>
            <begin position="156"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="283"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="818"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="928"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1068"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1266"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1372"/>
            <end position="1394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1614"/>
            <end position="1638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="818"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="928"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1266"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1616"/>
            <end position="1633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG5486059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="2250" mass="244163" checksum="DD0CEB6073C43690" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H5W0</accession>
    <name>A0A836H5W0_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000011">
        <property type="protein sequence ID" value="KAG5485349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065086.1">
        <property type="nucleotide sequence ID" value="XM_067207912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H5W0"/>
    <dbReference type="GeneID" id="92361846"/>
    <dbReference type="KEGG" id="loi:92361846"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5485349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="132" mass="15380" checksum="6AB358E1F4433AAE" modified="2021-09-29" version="1">MLRATVTRRSGFNVKELYPHGVPRRTFPYREHQKQISLAPTAGGFYVTKHALGWPFQIPFEWLFYRSSVTFFVFCVAYDMLFGLPHPFMKEVPPGTPHHFFFGNAGGTPHHLWQYQDGWTVPNMSGGRRWCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H6T3</accession>
    <name>A0A836H6T3_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062336.1">
        <property type="nucleotide sequence ID" value="XM_067207033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H6T3"/>
    <dbReference type="SMR" id="A0A836H6T3"/>
    <dbReference type="GeneID" id="92360967"/>
    <dbReference type="KEGG" id="loi:92360967"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5476103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="70" mass="8008" checksum="74A3F607F6C853F8" modified="2021-09-29" version="1">MHDVRCPDGPSSERNSTPFIMFEVFCACTLAVSTFFVYRLRRQAESRAQQRYDRLDRFEGGTGVCNVPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H711</accession>
    <name>A0A836H711_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methylated-DNA--protein-cysteine methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.63</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">6-O-methylguanine-DNA methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">O-6-methylguanine-DNA-alkyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LSCM4_05187</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = S-methyl-L-cysteinyl-[protein] + a 2'-deoxyguanosine in DNA</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MGMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.63" evidence="4"/>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062441.1">
        <property type="nucleotide sequence ID" value="XM_067207138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H711"/>
    <dbReference type="GeneID" id="92361072"/>
    <dbReference type="KEGG" id="loi:92361072"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001497">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46460">
        <property type="entry name" value="METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46460:SF1">
        <property type="entry name" value="METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="Methylated DNA-protein cysteine methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00374">
        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding" evidence="14">
        <location>
            <begin position="172"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG5476208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="284" mass="30143" checksum="A10B1B644FFD4A27" modified="2021-09-29" version="1">MAAQAKLAEHTANAKAAAKKASKRAPFSSSSSAMSRRHAQAASAALQRTESLPLYLRTVTTPLGPFSLYVDAEGAVRCCRWQRSAPGDAAALRTEAQEVCAAMQSRWYKSVLVTVAGVWADGAAGASEAPGGGAVALLRNYFNPPTPKSGRPEELERLLLQVPIVYPPTTVFTAQAWSTLRHTVPSGEIISYKGLGVRVHKALKLPASTAVAPRAIGVAMGANPIPVIVPCHRVLSSSNSLHGYGLGLRFKTWLLRHEQADVAADKLRVGEEENAVSTVASRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H7L1</accession>
    <name>A0A836H7L1_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_08343</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000001">
        <property type="protein sequence ID" value="KAG5488266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066313.1">
        <property type="nucleotide sequence ID" value="XM_067210212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H7L1"/>
    <dbReference type="GeneID" id="92364146"/>
    <dbReference type="KEGG" id="loi:92364146"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015098">
        <property type="term" value="F:molybdate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008509">
        <property type="entry name" value="MOT2/MFSD5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23516:SF1">
        <property type="entry name" value="MOLYBDATE-ANION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23516">
        <property type="entry name" value="SAM (S-ADENOSYL METHIONINE) TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="425"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="457"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5488266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="587" mass="62039" checksum="9ED46600F5B2CE9E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H7P8</accession>
    <name>A0A836H7P8_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_07839</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000006">
        <property type="protein sequence ID" value="KAG5487349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065846.1">
        <property type="nucleotide sequence ID" value="XM_067209716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H7P8"/>
    <dbReference type="SMR" id="A0A836H7P8"/>
    <dbReference type="GeneID" id="92363650"/>
    <dbReference type="KEGG" id="loi:92363650"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5487349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="57" mass="6600" checksum="8346F63F7EDB04A5" modified="2021-09-29" version="1">MHGVAKRATIPVSYRRNKYKVPLKFDTRKHPAGKKILMRYTNCDITNGIQETTLPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H7U7</accession>
    <name>A0A836H7U7_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
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                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="4">RING-type domain-containing protein</fullName>
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        <name evidence="5" type="ORF">LSCM4_05100</name>
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        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Leishmania</taxon>
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    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067207071.1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
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    </dbReference>
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        <property type="entry name" value="Znf_RING"/>
    </dbReference>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ZF_RING_2"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="136"/>
            <end position="183"/>
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            <begin position="29"/>
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    </feature>
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    <feature type="coiled-coil region" evidence="2">
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        </location>
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            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5476141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="501" mass="53221" checksum="05FA2956C779B643" modified="2021-09-29" version="1">MLLHEALVYTECPICLQPLDCRLRPPLSRPACTPSRGTSATAATGIGSANSSGEPGGSPLQPSRPNATGGAGEFRITFGPGVYGSDAADPWHPSLTVPTPAPPREVPDSSDQNRSAYNESRLPFSGDGSDLPGHGHSACSSSGSGSEEGAAGVVVLPCGHLLHHLCVMQLCEYATHLSCPVCRLKLASDVDVILFRPQLRVSSIAAAQALVSVPSSCYQAEGKCMTASATRKRSRAEEAGREEEEAPYAGSLRADGDATGSLQSVSCESTSQRVGVPDRAVACTSTVQPSLERRTATPIFGHDVEPMDTGAAPETPALPGVWRQKSSADGSTSQGEDDITIVGARQLPPSQAYAELLLRTTASWAARTETLKARVEHLERSRQLLQSDCSELERTLTVARRRREVLLNLPSSKEQEDALRSAHRLRELRRLCLETRAAITTATAHLAEAVRDHAEVRRQTEKYTRKLARLEGGEGGRSTPVDPAPAPATVARANLQPPSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HF06</accession>
    <name>A0A836HF06_9TRYP</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">LSCM4_04140</name>
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    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062066.1">
        <property type="nucleotide sequence ID" value="XM_067206129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HF06"/>
    <dbReference type="GeneID" id="92360063"/>
    <dbReference type="KEGG" id="loi:92360063"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5475558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="926" mass="99579" checksum="CA7300B56B719F60" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HG06</accession>
    <name>A0A836HG06_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_04363</name>
    </gene>
    <organism evidence="2 3">
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_067206348.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="92360282"/>
    <dbReference type="KEGG" id="loi:92360282"/>
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        <property type="component" value="Chromosome 25"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="667"/>
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    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="691"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5477146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="713" mass="79005" checksum="A35E014724049319" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HGH8</accession>
    <name>A0A836HGH8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CNH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000019">
        <property type="protein sequence ID" value="KAG5480858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067208347.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="loi:92362281"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Vam6/VPS39/TRAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894">
        <property type="entry name" value="CNH DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894:SF46">
        <property type="entry name" value="CNH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5480858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1280" mass="133319" checksum="3B6A22A091C07245" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HPL4</accession>
    <name>A0A836HPL4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Treble clef zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_06169</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000020">
        <property type="protein sequence ID" value="KAG5480403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063734.1">
        <property type="nucleotide sequence ID" value="XM_067208094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HPL4"/>
    <dbReference type="GeneID" id="92362028"/>
    <dbReference type="KEGG" id="loi:92362028"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025487">
        <property type="entry name" value="DUF4379"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37317">
        <property type="entry name" value="BLR8090 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37317:SF1">
        <property type="entry name" value="ZINC-RIBBON DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14311">
        <property type="entry name" value="DUF4379"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Treble clef zinc finger" evidence="2">
        <location>
            <begin position="75"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="647"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5480403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="746" mass="78342" checksum="7993D7C05A814881" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HW53</accession>
    <name>A0A836HW53_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000011">
        <property type="protein sequence ID" value="KAG5485366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065103.1">
        <property type="nucleotide sequence ID" value="XM_067207929.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92361863"/>
    <dbReference type="KEGG" id="loi:92361863"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="590"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1269"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1546"/>
            <end position="1567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="607"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1291"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1307"/>
            <end position="1318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5485366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1921" mass="199722" checksum="8F23FDFAE26574CF" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HWA4</accession>
    <name>A0A836HWA4_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_04885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000014">
        <property type="protein sequence ID" value="KAG5483733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064672.1">
        <property type="nucleotide sequence ID" value="XM_067206863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HWA4"/>
    <dbReference type="SMR" id="A0A836HWA4"/>
    <dbReference type="GeneID" id="92360797"/>
    <dbReference type="KEGG" id="loi:92360797"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5483733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="126" mass="14860" checksum="550C74222659EB2C" modified="2021-09-29" version="1">MSLCTSPARLQLCRTPFVLGTGGKWWKEGPPDYTRANRRRMELEQQRIEASQYLPPIEPTPEQACRLYRRLLKEGYKTLVVTDKDFYRRKVRYELEVTSRQTSSRVRGIMLEKGHWMLENKLGGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HXI4</accession>
    <name>A0A836HXI4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinate dehydrogenase assembly factor 3</fullName>
            <shortName evidence="6">SDH assembly factor 3</shortName>
            <shortName evidence="6">SDHAF3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_07914</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">LSCM4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with the iron-sulfur protein subunit within the SDH catalytic dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the complex I LYR family. SDHAF3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000013">
        <property type="protein sequence ID" value="KAG5484348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064841.1">
        <property type="nucleotide sequence ID" value="XM_067209791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HXI4"/>
    <dbReference type="GeneID" id="92363725"/>
    <dbReference type="KEGG" id="loi:92363725"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006105">
        <property type="term" value="P:succinate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008381">
        <property type="entry name" value="SDHAF3/Sdh7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13137">
        <property type="entry name" value="DC11 ACN9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13137:SF6">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13233">
        <property type="entry name" value="Complex1_LYR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5484348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="286" mass="31400" checksum="0EF2AB8C0DD51814" modified="2021-09-29" version="1">MWAVQPSYTNLVLPAIRAQRRCGALAAAARRYASTLSSRGGRSDDACANGIDADAVARPMGYGPFSATAKARLAREKAQKAARTADTAVPTASATVMNNVGLDTNLCLRLSLAGLLHPSQLQKQTYRSPEWRLAFVRLYRTILRLHNKEVAVSLSTSREQGPEAALSAVTGVHAASQATATKAGHSLAEDKEDYLLRYLLTPEQQEFGNRFVQGEFTRHIDADAVAAAIFYTSWYEYVLQLASGVTAREMTEKEKRLLSDEQKEALNSLRGAFFDLRASRQPKYMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HY50</accession>
    <name>A0A836HY50_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">STI1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_07424</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">LSCM4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000008">
        <property type="protein sequence ID" value="KAG5486491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065557.1">
        <property type="nucleotide sequence ID" value="XM_067209314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HY50"/>
    <dbReference type="SMR" id="A0A836HY50"/>
    <dbReference type="GeneID" id="92363248"/>
    <dbReference type="KEGG" id="loi:92363248"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000010">
        <property type="entry name" value="Stress-induced phosphoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000020">
        <property type="entry name" value="Stress-induced phosphoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.100:FF:000002">
        <property type="entry name" value="Stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000027">
        <property type="entry name" value="stress-induced-phosphoprotein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041243">
        <property type="entry name" value="STI1/HOP_DP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006636">
        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904:SF523">
        <property type="entry name" value="STRESS-INDUCED-PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904">
        <property type="entry name" value="TPR REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17830">
        <property type="entry name" value="STI1-HOP_DP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00727">
        <property type="entry name" value="STI1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="3"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="71"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="STI1" evidence="7">
        <location>
            <begin position="131"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="224"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="359"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="393"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="427"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="STI1" evidence="7">
        <location>
            <begin position="495"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="189"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="209"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5486491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="547" mass="62129" checksum="B83C1E34B3DB9DF7" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836I189</accession>
    <name>A0A836I189_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP-dependent Clp protease subunit, heat shock protein 78 (HSP78)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_08196</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000002">
        <property type="protein sequence ID" value="KAG5488216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066264.1">
        <property type="nucleotide sequence ID" value="XM_067210066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836I189"/>
    <dbReference type="GeneID" id="92364000"/>
    <dbReference type="KEGG" id="loi:92364000"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19499">
        <property type="entry name" value="RecA-like_ClpB_Hsp104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000120">
        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000025">
        <property type="entry name" value="ATP-dependent Clp protease subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000010">
        <property type="entry name" value="Chaperone clpB 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050130">
        <property type="entry name" value="ClpA_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638:SF176">
        <property type="entry name" value="HEAT SHOCK PROTEIN 78, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="147"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="547"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="domain" description="Clp ATPase C-terminal" evidence="9">
        <location>
            <begin position="716"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="63"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="362"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5488216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="825" mass="91406" checksum="8F5147DE3EF2F212" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836I2J7</accession>
    <name>A0A836I2J7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleoplasmin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_06319</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
            <dbReference type="Pfam" id="PF17800"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <begin position="1074"/>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836I4I3</accession>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067202566.1"/>
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    <dbReference type="KEGG" id="loi:92356500"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
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    </dbReference>
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        <property type="entry name" value="Alpha-type_PK"/>
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    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
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    <dbReference type="PANTHER" id="PTHR45992:SF2">
        <property type="entry name" value="EUKARYOTIC ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45992">
        <property type="entry name" value="EUKARYOTIC ELONGATION FACTOR 2 KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02816">
        <property type="entry name" value="Alpha_kinase"/>
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    </dbReference>
    <dbReference type="SMART" id="SM00811">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51158">
        <property type="entry name" value="ALPHA_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="199"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="20"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
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        <source>
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        </source>
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        <source>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
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                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469129.1"/>
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    </dbReference>
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    </evidence>
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        <source>
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    <sequence length="86" mass="8989" checksum="628048E5DE394F83" modified="2021-09-29" version="1">MLYERHEAWAGVNSELSEATAVLPRVQREASVSCGYWHGRRPGVQGSGGGIGGVGGVCGAACGRSYEHHHLVADARPVVLPSHARG</sequence>
</entry>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
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    <sequence length="181" mass="20296" checksum="03F76AEE1CA141C4" modified="2021-09-29" version="1">MFSIRFRGVDLDPEMTPPMLCGALSRKAAPLRPTVSPVDSEADENAGSRGLGVARATRWQGSCCHRQRNREEGGHSRQKKYISMQQAPTTAVASWFTSPATQNAIRPRRRLVKRREITEKALSRVLRLAYTKTKRILHIAPQRISRPGACAVRTLFPLLPSLSDFVSHRPSFPFSCSENLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
            <dbReference type="EMBL" id="KAG5468021.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="39462" checksum="166B41D5A09EA350" modified="2021-09-29" version="1">MRARRSSKFAEYLSTYAILEHVGIHPTTLIEKRDAAVGVGIYVRDACDAGTTLLAVPSKRFCTNSVLSRVGLKTYFCSPWPGDSEGLSTVSAGPVCDVQGGILTFLTGSAQWPELAWRLALEQHRSVSPLWGWLQSLPSMEELADLRDTAERQCRVHHTMLLPYYLKGRQRIREETVAAYSQLRARNILPCFDRFAWAVDVVLSRGLLLPTAWPVISGASASSRTDGKRDEVENDFLSHSSLECGVVPFLDLVNAPDDVGREANADIEIATSLEDLPPFLRDDLASGATARGRCGDDELAEVQRILETHYYICLTLRKPLRASEEVILDWQVPVLTTGVLTAADDTAVSRFLKYMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Uncharacterized protein</fullName>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Kwakye-Nuako G."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="protein sequence ID" value="KAG5468966.1"/>
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    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="808"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="611"/>
            <end position="621"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5468966.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
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    </evidence>
    <sequence length="1093" mass="118542" checksum="83DDCC3113E0DF9A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836KCW6_9TRYP</name>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469131.1"/>
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</entry>
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                <person name="Al-Salem W.S."/>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="3" key="1">
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            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060358.1">
        <property type="nucleotide sequence ID" value="XM_067204806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KEW7"/>
    <dbReference type="GeneID" id="92358740"/>
    <dbReference type="KEGG" id="loi:92358740"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23675">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5470092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="739" mass="80852" checksum="A8EB073522039A29" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KEZ1</accession>
    <name>A0A836KEZ1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rab11B GTPase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060433.1">
        <property type="nucleotide sequence ID" value="XM_067204881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KEZ1"/>
    <dbReference type="GeneID" id="92358815"/>
    <dbReference type="KEGG" id="loi:92358815"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001656">
        <property type="entry name" value="Rab11B GTPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5470167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="217" mass="24602" checksum="104BDB45389BA097" modified="2021-09-29" version="1">MTAPMKLLKPKTVFDNRPDELRKPIKLILLGDSAVGKSKLVERFLMQRYVPVQMSTYALTLYRYDFVTEDDEEEVDVDIWDTAGQERFATVHPSYYHDAHACILVFDSTRKATYKNLEKWLTEMRNYREHIPCIVACNKIDTDPSVTTKSFAFAEKHNFPLHYVSAADGSNVVQLFESAISTAAAYKKNPAKDDFMTQVIGMLKEDRTAAGTAAVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KF18</accession>
    <name>A0A836KF18_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_03140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060708.1">
        <property type="nucleotide sequence ID" value="XM_067205156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KF18"/>
    <dbReference type="GeneID" id="92359090"/>
    <dbReference type="KEGG" id="loi:92359090"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="55"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="578"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="320"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="418"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="671"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="578"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="609"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5471591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1265" mass="135893" checksum="B7D8DAD222CCB65F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KG14</accession>
    <name>A0A836KG14_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Importin subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_02039</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the importin alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061112.1">
        <property type="nucleotide sequence ID" value="XM_067204075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KG14"/>
    <dbReference type="SMR" id="A0A836KG14"/>
    <dbReference type="GeneID" id="92358009"/>
    <dbReference type="KEGG" id="loi:92358009"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000009">
        <property type="entry name" value="Importin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032413">
        <property type="entry name" value="Arm_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024931">
        <property type="entry name" value="Importin_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16186">
        <property type="entry name" value="Arm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005673">
        <property type="entry name" value="Importin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="127"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="212"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="297"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5472716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="539" mass="57727" checksum="2B1FBCF41A1A64E7" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KG37</accession>
    <name>A0A836KG37_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BILBO1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_02114</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061187.1">
        <property type="nucleotide sequence ID" value="XM_067204150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KG37"/>
    <dbReference type="SMR" id="A0A836KG37"/>
    <dbReference type="GeneID" id="92358084"/>
    <dbReference type="KEGG" id="loi:92358084"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040747">
        <property type="entry name" value="BILBO1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18281">
        <property type="entry name" value="BILBO1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BILBO1 N-terminal" evidence="2">
        <location>
            <begin position="14"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="316"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5472791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="409" mass="45481" checksum="2EE0FC2BB324AB10" modified="2021-09-29" version="1">MEFPVFVASDVHREKVNLALRYNPRTTTLDRFLRSASRCFDDVARFTRKGSLPPFSAAYLYSDVQCQWDVLQDRTQLSPCCQVYVFRHQAEEAVAVIPEPVESSELLLVLKGRFNTASFSTVASTVRQPSPINSPASTSPMLLASNRWALPQGSQHSATSRLRFGAPSSPCKGSAPLLRFADLTTSDTATHTDAHAGGFHNARPMDASVAFQPVRSHRFRLQIFSPPAETPMRGQGANRSTPNMYASLTERAASEPQALYLKPTRPYSSDLYKLPPASPPERGEVAIPRSWYDPSSHSFRSVAPRPRGSGQLPPQSSSVASRSRGAVLPSSARGSRQRPRMQTDESDPHLLVHREPRSGDGVSILREERERVSVQMRLEIDDLRSHLREETRQLKRTLNGAHCTVAIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KG83</accession>
    <name>A0A836KG83_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="6 14">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">LSCM4_02267</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 14">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 15">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="6 14"/>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061337.1">
        <property type="nucleotide sequence ID" value="XM_067204300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KG83"/>
    <dbReference type="SMR" id="A0A836KG83"/>
    <dbReference type="GeneID" id="92358234"/>
    <dbReference type="KEGG" id="loi:92358234"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000006">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000031">
        <property type="entry name" value="Phosphoglycerate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="entry name" value="Phosphoglycerate kinase, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015911">
        <property type="entry name" value="Phosphoglycerate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406:SF23">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE 1, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00111">
        <property type="entry name" value="PGLYCERATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="16">
        <location>
            <begin position="3"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG5472941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="527" mass="57766" checksum="1C054DF608B8584B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KGE4</accession>
    <name>A0A836KGE4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">mRNA (guanine-N(7))-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_00011</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:67008"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="Rhea" id="RHEA-COMP:17167"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.1.1.56"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.56" evidence="1"/>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058204.1">
        <property type="nucleotide sequence ID" value="XM_067202103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KGE4"/>
    <dbReference type="SMR" id="A0A836KGE4"/>
    <dbReference type="GeneID" id="92356037"/>
    <dbReference type="KEGG" id="loi:92356037"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004482">
        <property type="term" value="F:mRNA 5'-cap (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000618">
        <property type="entry name" value="Putative mRNA capping methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004971">
        <property type="entry name" value="mRNA_G-N7_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039753">
        <property type="entry name" value="RG7MT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12189:SF1">
        <property type="entry name" value="MRNA (GUANINE-N(7))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12189">
        <property type="entry name" value="MRNA GUANINE-7- METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03291">
        <property type="entry name" value="mRNA_G-N7_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51562">
        <property type="entry name" value="RNA_CAP0_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MRNA cap 0 methyltransferase" evidence="8">
        <location>
            <begin position="23"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5464573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="323" mass="35827" checksum="31528CE14DD7B15E" modified="2021-09-29" version="1">MSKHPTAVAYDDVTRKRKDDRSSQHVAFRHFNNFVKKALIQFSLDCALANAAASPAEGAAVLDLASGRGGDIGKWFFMRSHASNDPRAPSATLRTSFYDCYDVSFECINEAERRCREMMASMERPPQCCASFTVADCFTESFLRDTLPSSPHFGRYSVVTIQFAFHYACKSLHLVREVFSAISHALAPGGVVLITTVDIAMLSKRVAEGMMGNELYSISFPTPPEYAVASDGSALLVVGTEYHFRLEGFVDCPEYVVPYDAVVQIASESQLRLCEPLSKPFAEFVPEYAANWKANKGNKLSQAELELVTLYRTLCFEKARVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KGF3</accession>
    <name>A0A836KGF3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_03374</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060934.1">
        <property type="nucleotide sequence ID" value="XM_067205382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KGF3"/>
    <dbReference type="GeneID" id="92359316"/>
    <dbReference type="KEGG" id="loi:92359316"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="585"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="589"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5471817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="613" mass="64367" checksum="DCF3FBE77F516F80" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KGN7</accession>
    <name>A0A836KGN7_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_00334</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058519.1">
        <property type="nucleotide sequence ID" value="XM_067202418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KGN7"/>
    <dbReference type="GeneID" id="92356352"/>
    <dbReference type="KEGG" id="loi:92356352"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5464888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="378" mass="42155" checksum="7A8B6CC59CF25471" modified="2021-09-29" version="1">MARVLVNHEDCSVHIKGDFITFLYTTVAKDPLLVAARNVAQLLRSRKDDTAAKLVADGMSYVLKFACLRDREWFIESIVRAQEAKQEPSNGEWVASTICQAAVDVGVLDREELEAIMSAAGQRGVEQAFNALETLVDRETFQLLPITEQMENDVLRQIPVLAAIFQERVVDKETKKSFWEAVVRKYFCFSRTFLEEDIQRLEGARPTLTATPPPPLSGSAATSSLSVINASSVSALPKSAAISMVDTSINEEDLLYLERDAEPPQLSFQCLFAAHRHVPVSTASALPVSGAVLSFPKETAEPSPVHRPRFAGRRVLRQLPSETIEKTAVEALRIFWRGSVKQRRSVLAKYARSSKKDRCESFIQRMCLEQADRALQDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KIM9</accession>
    <name>A0A836KIM9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">GPN-loop GTPase 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_04492</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">LSCM4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062685.1">
        <property type="nucleotide sequence ID" value="XM_067206476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KIM9"/>
    <dbReference type="SMR" id="A0A836KIM9"/>
    <dbReference type="GeneID" id="92360410"/>
    <dbReference type="KEGG" id="loi:92360410"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17872">
        <property type="entry name" value="GPN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001526">
        <property type="entry name" value="GPN-loop GTPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030228">
        <property type="entry name" value="Gpn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF7">
        <property type="entry name" value="GPN-LOOP GTPASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5477274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="266" mass="29248" checksum="74CD08DD2BFF2D41" modified="2021-09-29" version="1">MGKYAAIVVGPAGSGKSTLCGVLAEHYATMGRSTHIANMDPAADLLPYEPSMDIRDLISLEDAMEGKGLGPNGGLVFCMEYLVTAGATWVSQQLGDYAEDFIIVDMPGQVEVLSNQPAVPAFVRLLQQEGYYTTVLYLLDALATTADSGKFIAGCMFSLSSMVCFDCPFINVLTKCDLLSKDFKENGVLEHFCMCDFDYMDLSRLPPRFRAMSRQIGALLTDFRLVTFRPVDIEEVRYVSNLCSLLDETLQVADEAEVQDHDLPDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KJI2</accession>
    <name>A0A836KJI2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Centrosomal protein of 97 kDa</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Dynein regulatory complex subunit 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Leucine-rich repeat and IQ domain-containing protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">LSCM4_02296</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Acts as a key negative regulator of ciliogenesis in collaboration with CCP110 by capping the mother centriole thereby preventing cilia formation. Required for recruitment of CCP110 to the centrosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Flagellum axoneme</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DRC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061366.1">
        <property type="nucleotide sequence ID" value="XM_067204329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KJI2"/>
    <dbReference type="SMR" id="A0A836KJI2"/>
    <dbReference type="GeneID" id="92358263"/>
    <dbReference type="KEGG" id="loi:92358263"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030030">
        <property type="term" value="P:cell projection organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000165">
        <property type="entry name" value="Centrosomal protein of 97 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050576">
        <property type="entry name" value="Cilia_flagella_integrity"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973:SF12">
        <property type="entry name" value="DYNEIN REGULATORY COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0282">Flagellum</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00040950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00058656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00068862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00076677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG5472970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="555" mass="63731" checksum="6D3D55263517A99F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KLB1</accession>
    <name>A0A836KLB1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_04435</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">LSCM4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. BUD32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062628.1">
        <property type="nucleotide sequence ID" value="XM_067206419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KLB1"/>
    <dbReference type="SMR" id="A0A836KLB1"/>
    <dbReference type="GeneID" id="92360353"/>
    <dbReference type="KEGG" id="loi:92360353"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001440">
        <property type="entry name" value="Protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000201">
        <property type="entry name" value="TP53-regulating kinase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209:SF0">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT TP53RK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209">
        <property type="entry name" value="NON-SPECIFIC SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06293">
        <property type="entry name" value="Kdo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="19"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5477217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="284" mass="30755" checksum="E396FB71FA52ED5E" modified="2021-09-29" version="1">MSASYAQAEPGPGRSVHSIELGSLIFQGAESKVYHCSFYGAPAVCKHRFAKRYRNPILDERLRSQRTRREARALERCVKKGIRAPRLLGADYINTFLVMSYEAGPTVKEALDMDHAAYVQQASKGKVAPAQQLQQQPIPSPVTSALLQSIGVIVARLHNANIVHGDLTTSNFICACVGQPAAAAASNADGTAALESSAPVLPTAEDIVVLDFGLISDKYSAEERAVDLYVLERAITSTHPYLSAFASDVILEGYRSATDPEKGEEALRRLEAVRARGRKRSMVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KLD9</accession>
    <name>A0A836KLD9_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_02676</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5469988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060254.1">
        <property type="nucleotide sequence ID" value="XM_067204702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KLD9"/>
    <dbReference type="SMR" id="A0A836KLD9"/>
    <dbReference type="GeneID" id="92358636"/>
    <dbReference type="KEGG" id="loi:92358636"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044640">
        <property type="entry name" value="RU2A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10552:SF10">
        <property type="entry name" value="U2 SMALL NUCLEAR RIBONUCLEOPROTEIN 40K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10552">
        <property type="entry name" value="U2 SMALL NUCLEAR RIBONUCLEOPROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5469988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="307" mass="34641" checksum="794F67DBFF0870D6" modified="2021-09-29" version="1">MRLTMDLVRLAPQFTNTMLQREIDLRGLRISSLDEQVLVLLDNNFDVVNLSSNALTALEYFPTKTAVGSSDKDVRMSRVTTLIAHRNEIQRVSVASCVSALPNVVHFLADRNRLACVRDLFFLKHWKKLEMVSLEDNPVWERNSSNYDREKLRAFLVFLCPKLKLINYQRVTQTDRERAQEAKDEFKQLVQLWEAPLTASRLQPSFTADGKKVRKRARECRAAAAAAATATSDAVAIDDGHGNGATSATPAAADVNEDDDDALQARLDHLEERLLSDDVTAEEITRLEEEMAEIAARMTAARKRSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KLI7</accession>
    <name>A0A836KLI7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arf-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_02832</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060404.1">
        <property type="nucleotide sequence ID" value="XM_067204852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KLI7"/>
    <dbReference type="SMR" id="A0A836KLI7"/>
    <dbReference type="GeneID" id="92358786"/>
    <dbReference type="KEGG" id="loi:92358786"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08204">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000009">
        <property type="entry name" value="stromal membrane-associated protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051718">
        <property type="entry name" value="ARF_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705:SF1">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="13"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="371"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="425"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="656"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="378"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="399"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5470138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="730" mass="78648" checksum="D365AC2935B452E5" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KN48</accession>
    <name>A0A836KN48_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein RER1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_01801</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">LSCM4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the RER1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000022">
        <property type="protein sequence ID" value="KAG5479212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063305.1">
        <property type="nucleotide sequence ID" value="XM_067203846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KN48"/>
    <dbReference type="GeneID" id="92357780"/>
    <dbReference type="KEGG" id="loi:92357780"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004932">
        <property type="entry name" value="Rer1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10743">
        <property type="entry name" value="PROTEIN RER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10743:SF0">
        <property type="entry name" value="PROTEIN RER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03248">
        <property type="entry name" value="Rer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016013">
        <property type="entry name" value="AtER_Rer1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5479212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="183" mass="21099" checksum="37CEB4769E9A5344" modified="2021-09-29" version="1">MPLSHDLLGPNNGNSLVRKARLTYKRYLDASVPHRGMRWCFFAFLVILYVARVVTFGGFYVITYGLCIHLLYLLLMLITPLSEPDEGDVTSLPTTHADGDEYRPFMPKVQEFVVWKQMFTVVFVSLFLTMFSFLDIPVFWPILVLYFLVLFATQVGGRVRHMIKHGYVPWNAGKPKFVPKNTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KNK7</accession>
    <name>A0A836KNK7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_04342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062536.1">
        <property type="nucleotide sequence ID" value="XM_067206327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KNK7"/>
    <dbReference type="GeneID" id="92360261"/>
    <dbReference type="KEGG" id="loi:92360261"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070042">
        <property type="term" value="F:rRNA (uridine-N3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019446">
        <property type="entry name" value="BMT5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF26">
        <property type="entry name" value="FERREDOXIN-FOLD ANTICODON-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10354">
        <property type="entry name" value="BMT5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="444"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="510"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="543"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5477125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="573" mass="63210" checksum="422EFA129150C6F0" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KQ66</accession>
    <name>A0A836KQ66_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_07159</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000018">
        <property type="protein sequence ID" value="KAG5481447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064126.1">
        <property type="nucleotide sequence ID" value="XM_067209063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KQ66"/>
    <dbReference type="SMR" id="A0A836KQ66"/>
    <dbReference type="GeneID" id="92362997"/>
    <dbReference type="KEGG" id="loi:92362997"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000169">
        <property type="entry name" value="Kinesin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115:SF929">
        <property type="entry name" value="KINESIN-LIKE PROTEIN AT 31E, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115">
        <property type="entry name" value="KINESIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="3">
        <location>
            <begin position="5"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="378"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="584"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="664"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="764"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="584"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="598"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="677"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="713"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="781"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="91"/>
            <end position="98"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5481447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="792" mass="85632" checksum="07B8581F6C9E2C1E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KQR0</accession>
    <name>A0A836KQR0_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_01862</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000022">
        <property type="protein sequence ID" value="KAG5479270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063363.1">
        <property type="nucleotide sequence ID" value="XM_067203904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KQR0"/>
    <dbReference type="SMR" id="A0A836KQR0"/>
    <dbReference type="GeneID" id="92357838"/>
    <dbReference type="KEGG" id="loi:92357838"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="496"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="372"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5479270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="565" mass="60210" checksum="2DA38A999E492051" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KSQ9</accession>
    <name>A0A836KSQ9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase subunit H/Rpb5 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_07081</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000018">
        <property type="protein sequence ID" value="KAG5481370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064049.1">
        <property type="nucleotide sequence ID" value="XM_067208986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KSQ9"/>
    <dbReference type="GeneID" id="92362920"/>
    <dbReference type="KEGG" id="loi:92362920"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.940.20:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1340.10">
        <property type="entry name" value="RNA polymerase, Rpb5, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.20">
        <property type="entry name" value="RPB5-like RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014381">
        <property type="entry name" value="Arch_Rpo5/euc_Rpb5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036710">
        <property type="entry name" value="RNA_pol_Rpb5_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000783">
        <property type="entry name" value="RNA_pol_subH/Rpb5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035913">
        <property type="entry name" value="RPB5-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10535">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10535:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01191">
        <property type="entry name" value="RNA_pol_Rpb5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53036">
        <property type="entry name" value="Eukaryotic RPB5 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55287">
        <property type="entry name" value="RPB5-like RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase subunit H/Rpb5 C-terminal" evidence="5">
        <location>
            <begin position="267"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="69"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="86"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5481370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="340" mass="37413" checksum="147D3DD43D864FBC" modified="2021-09-29" version="1">MSSIEELKAVRLFRALNTMIQLCHDRGYVIRHPSAIAEAVQDPKLYDKEEGLDYDWFLRHFVVSPDRVAGSTRAKKSGGNGNASSPRREAKNEEGDDDAGRTGECGEAVDEADMLRRAANGEWVCMRNAMRLTCSLDPRFAPPAPGVLSGAAANTTRSSASAVKVVPKDGDAPNAVLEATMDTKSKEKAAKNALIVFFSGSPKLNIKEVQIFREKALKKRAASMIIVTNKVDPGVRMDVQELSGRMDETTGAELLSIQVFEEEALAFNVVHHETVPRHVALTPAEAEKFLAEQKLNIAQLPRMQESDPLVQYLGLRRGSIVHITREGKQSGPYSMYRHVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KT42</accession>
    <name>A0A836KT42_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_06850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000017">
        <property type="protein sequence ID" value="KAG5481775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064135.1">
        <property type="nucleotide sequence ID" value="XM_067208761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KT42"/>
    <dbReference type="GeneID" id="92362695"/>
    <dbReference type="KEGG" id="loi:92362695"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5481775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="80" mass="9169" checksum="9086E2B36F379E21" modified="2021-09-29" version="1">MRAGGHTEAAVRCHCMVGKLPIHHADHCRSTQVHLRPYSSYLDSRRQRGELWCAHVMFRITVPICTRCAYVSSYRKGSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KTW4</accession>
    <name>A0A836KTW4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial</fullName>
            <ecNumber evidence="15">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">LSCM4_05457</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 15">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="13">Flavinylated by SdhE, about 5% flavinylation occurs in the absence of SdhE.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Mitochondrion inner membrane</location>
            <topology evidence="15">Peripheral membrane protein</topology>
            <orientation evidence="15">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="15"/>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5478058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062965.1">
        <property type="nucleotide sequence ID" value="XM_067207397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KTW4"/>
    <dbReference type="SMR" id="A0A836KTW4"/>
    <dbReference type="GeneID" id="92361331"/>
    <dbReference type="KEGG" id="loi:92361331"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000001">
        <property type="entry name" value="Mitochondrial succinate dehydrogenase flavoprotein subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.80.40:FF:000002">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.100:FF:000001">
        <property type="entry name" value="Succinate dehydrogenase flavoprotein subunit (SdhA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.100">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.40">
        <property type="entry name" value="succinate dehydrogenase protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003952">
        <property type="entry name" value="FRD_SDH_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011281">
        <property type="entry name" value="Succ_DH_flav_su_fwd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014006">
        <property type="entry name" value="Succ_Dhase_FrdA_Gneg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01816">
        <property type="entry name" value="sdhA_forward"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01812">
        <property type="entry name" value="sdhA_frdA_Gneg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE 2 FLAVOPROTEIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF51">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000171">
        <property type="entry name" value="SDHA_APRA_LASPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00504">
        <property type="entry name" value="FRD_SDH_FAD_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 13 15" id="KW-0274">FAD</keyword>
    <keyword evidence="5 13 15" id="KW-0285">Flavoprotein</keyword>
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            <end position="33"/>
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        </ligand>
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    <feature type="binding site" evidence="13">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
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            <position position="234"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
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            <position position="255"/>
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        <ligand>
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        </ligand>
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            <position position="267"/>
        </location>
        <ligand>
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        </ligand>
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            <position position="366"/>
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        <ligand>
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        </location>
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        </source>
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            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="607" mass="66650" checksum="C286859B60D2174F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Leishmania orientalis</name>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG5487341.1"/>
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    <dbReference type="KEGG" id="loi:92363642"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="EMBL" id="KAG5487341.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
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</entry>
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    <name>A0A836KWR2_9TRYP</name>
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        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
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        <name evidence="5" type="ORF">LSCM4_06663</name>
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        <name type="scientific">Leishmania orientalis</name>
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        </lineage>
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    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
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                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RING-type zinc finger family. LOG2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000010">
        <property type="protein sequence ID" value="KAG5485705.1"/>
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        <property type="nucleotide sequence ID" value="XM_067208578.1"/>
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    <dbReference type="KEGG" id="loi:92362512"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="mRING-HC-C3HC5_MGRN1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045195">
        <property type="entry name" value="LOG2-like_mRING_C3HC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045194">
        <property type="entry name" value="MGRN1/RNF157-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22996">
        <property type="entry name" value="MAHOGUNIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22996:SF0">
        <property type="entry name" value="RE60872P-RELATED"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="320"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="204"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5485705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="368" mass="39759" checksum="E7E0034BD4F0634D" modified="2021-09-29" version="1">MGNRTSHQQPAETAVSGLELRLAPHNFYLVFGKPSIRFVRDRVRGPLIYDVEVEYDDDENLVEHAAALGLTCAVPRRQKIDLISAPSPSPRAVGASKGLALTFKIAATQPPQRVRVYAGASVEYRAHEGVRLKTSGGVAAGSVCILDTTETDGLTTVVTNPLVLPQLLQPVKYEETANARTGSTVQRVAYAPLAIEVLVGQGEGLTEKSQRSSPADKAAHGATPPRPSPASSPARRPPLKVGKKDIVHYTFLEVLEGAAKLSVSPPGGREARDAVRFDCKVAKQLLQVGNQVYDLEDVFDDSHEVDVVSPVANEDEEGLCVICLTNQKDTTILPCRHMCLCSECAIHLRLTNNRCPLCRGSIDRVMTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KXQ4</accession>
    <name>A0A836KXQ4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_06884</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000017">
        <property type="protein sequence ID" value="KAG5481808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064168.1">
        <property type="nucleotide sequence ID" value="XM_067208794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KXQ4"/>
    <dbReference type="GeneID" id="92362728"/>
    <dbReference type="KEGG" id="loi:92362728"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16448">
        <property type="entry name" value="RING-H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="891"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="166"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="337"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="482"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="349"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="493"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5481808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1049" mass="113454" checksum="9078B4AA24EFDD69" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KXT3</accession>
    <name>A0A836KXT3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ADP/ATP translocase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">ADP,ATP carrier protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_06311</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the exchange of ADP and ATP across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000007">
        <property type="protein sequence ID" value="KAG5486845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065639.1">
        <property type="nucleotide sequence ID" value="XM_067208234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KXT3"/>
    <dbReference type="SMR" id="A0A836KXT3"/>
    <dbReference type="GeneID" id="92362168"/>
    <dbReference type="KEGG" id="loi:92362168"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140021">
        <property type="term" value="P:mitochondrial ADP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990544">
        <property type="term" value="P:mitochondrial ATP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002113">
        <property type="entry name" value="ADT_euk_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635">
        <property type="entry name" value="ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635:SF42">
        <property type="entry name" value="ADP_ATP TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="83"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="179"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="282"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5486845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="366" mass="39906" checksum="B8B3A79DEFD65B2D" modified="2021-09-29" version="1">MPVTRAAAQGSSSDSGSDSAYSAGERSLASSSSYDGRTPEGGHAGSSNSLSSSSHESASSHGGQGSLYEGDGSTIISVEYIQRLWLMRAISRTVLAPLERVKYVMQCQKELQRTGALQCEFKTVWACVRYLKQVEGMRSFWRGNFIQVVSLLPILLAQIFIAYPTQSLIFNSFVVHSAAGYTLASYAALLGGALAATTVSYPLEYARFRLAVDVKSRASAPYQFRNSFAFYSHPVMSECPHFLYRGLTLFIFGSVVYQSVHNVLLNLVAPYVPPDDEDNGWTPAIIQTMCGLTVSGTTTLCLHPVDLVRHRMMVAVMEDRLRYSSAMTCVARIAQKEGIRGFFRGGTVTLTKMMAATGLVLVGLPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KY71</accession>
    <name>A0A836KY71_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_07785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058268.1">
        <property type="nucleotide sequence ID" value="XM_067202167.1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="399"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5464637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="429" mass="46393" checksum="296628D4DB148F52" modified="2021-09-29" version="1">MSADSNSFSTYIDHLILLLAARFHAPLNVSVEDPLPSGVNAPAESQSPWELVARAVQQALRAPQTEQERRLVRQLDVHLFSASVCRERARYMQWKLQEIPRLRGDQQQLSPSSRMLAADAANKSSAVAASPTAAGQPYDVTRRSLHEEVRSLYALVRQSLPSTLGDTESGDEGDAQAPASLVQSAAPASEPSVFASVREVFVRTPAERERDEQVARARDEFLSEVQALQSAYYDKYRRWMDVPESILDPPPYARKQLANANGAASAPESDSGSQRAASREALGAAAPLSLHLTAQANRINGSAAADGSERLDTLASVFRQIQLQRPLRPSAVPDDLLERMYCVHAESEEGLENRSSASDWRSSVLSAFTSMPPSLAGASADTIVAGAVSAAPPSPQPPSSAAAARKDTAPPASRRGRWQIVEYDDDDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FM71</accession>
    <name>A0A836FM71_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thymocyte nuclear protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_00737</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058913.1">
        <property type="nucleotide sequence ID" value="XM_067202812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836FM71"/>
    <dbReference type="SMR" id="A0A836FM71"/>
    <dbReference type="GeneID" id="92356746"/>
    <dbReference type="KEGG" id="loi:92356746"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd21133">
        <property type="entry name" value="EVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.590.10:FF:000003">
        <property type="entry name" value="Thymocyte nuclear protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052181">
        <property type="entry name" value="5hmC_binding"/>
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    </dbReference>
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        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047197">
        <property type="entry name" value="THYN1-like_EVE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14087">
        <property type="entry name" value="THYMOCYTE NUCLEAR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14087:SF7">
        <property type="entry name" value="THYMOCYTE NUCLEAR PROTEIN 1"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF01878">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EVE" evidence="5">
        <location>
            <begin position="13"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5465282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="164" mass="19162" checksum="D6AD6FD2909E4E34" modified="2021-09-29" version="1">MSRKRLRSEDIHYWLMKSEPHKFSIDDLARQKISPWDGVRNYAARNNLRAMAVGDKVLFYHSNTKEPGVAGLAEVVRLAYDDFTALDKTSDYFDPKATKEKNPWQMVDVKFVAKWDAVVTLREMKSRRELQQMALFTQSRLSVQPVGAAEYAYIVRMNEEQQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FNQ0</accession>
    <name>A0A836FNQ0_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059012.1">
        <property type="nucleotide sequence ID" value="XM_067203321.1"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A836FNQ0"/>
    <dbReference type="GeneID" id="92357255"/>
    <dbReference type="KEGG" id="loi:92357255"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5466122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="236" mass="27995" checksum="88CBA30B94276D1C" modified="2021-09-29" version="1">MAPKRNNAKRETKRKELTEEDMLRLGMTPEDIQRILGERGKSSEDKQAEHAREEAQRREAEARQRQQRDHQKQVDSMIGEEVTTRATLRYDEDQEWTQMESGELTPAKQKILRHLAVVEAQRRAEEAKRRQAEELAAYQAKLQSMTEEQRAIFLEEEKEKEKRRIEDIVASEEKRMERERRREARRRARKERLLNNQNADDLLSSDDDEPGAKDTKKKGKEAAIDELEFNLHEKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FP46</accession>
    <name>A0A836FP46_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_01542</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the SMC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059282.1">
        <property type="nucleotide sequence ID" value="XM_067203591.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836FP46"/>
    <dbReference type="GeneID" id="92357525"/>
    <dbReference type="KEGG" id="loi:92357525"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1620:FF:000011">
        <property type="entry name" value="Structural maintenance of chromosomes protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002923">
        <property type="entry name" value="Structural maintenance of chromosomes protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF12">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="10">
        <location>
            <begin position="560"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="987"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1042"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="247"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="345"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="497"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="740"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="881"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1008"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1045"/>
            <end position="1058"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5466392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1321" mass="146814" checksum="B79EB3099FDD4E69" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FRE4</accession>
    <name>A0A836FRE4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_00837</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059559.1">
        <property type="nucleotide sequence ID" value="XM_067202909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836FRE4"/>
    <dbReference type="SMR" id="A0A836FRE4"/>
    <dbReference type="GeneID" id="92356843"/>
    <dbReference type="KEGG" id="loi:92356843"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320:SF1">
        <property type="entry name" value="PROTEIN PHOSPHATASE PTC7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="23"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5467757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="280" mass="30289" checksum="FD3E09492B8F6A71" modified="2021-09-29" version="1">MISSTRACRCVSKAALRFGHRGACAIPHPKKAYRGGEDAYAFHPYCIGVADGVGGYASQGIEPAIYTRNVMRFTLEYVEREASSSKRATALAALNYGYKKANDAKQPGGCPVALATIVDNTHASLLNLGDCGLVIVRQGKLLYRTEIQQHSFNCPYQLPGDPPSAGEQAKIEVRVGDVFLCVSDGVLDNVELDRLLDHLSEVPTTGCRNVAEAIGQEAFRNGQDRRYFSPFARHAEEAGYRYTGGKLDDITALVAQVTADNEEGASNCPPLITMLLNIDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G1Q2</accession>
    <name>A0A836G1Q2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061415.1">
        <property type="nucleotide sequence ID" value="XM_067205478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G1Q2"/>
    <dbReference type="SMR" id="A0A836G1Q2"/>
    <dbReference type="GeneID" id="92359412"/>
    <dbReference type="KEGG" id="loi:92359412"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14273">
        <property type="entry name" value="UBA_TAP-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322:SF6">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5473412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="428" mass="46085" checksum="E38F340EBF421BA8" modified="2021-09-29" version="1">MSDVDVVANFVVMTGATEDQAIHYLSTYDFNLEDAVVAFQVDNPHPSPPHIQEDSPHYSSVDTGSPLSAPSPASHQVEGFAFPQSAQRPPTPPRQRVLASSTTEAIQRLFARPDYVVGSDRVAFDAECEKAASRHCWVVVSVVDNSFPCECFTRDIWASDAMRSLTSGSLFCYEINVTHTRGMALAEKYHVDSGHLPRMFMVDPVTQFKVQELPLISSEVWQFDSAMVVDAIMLFITNHDPPHDPFASTDDQPHSELGGGGSGGAAPASASAVETVVVDVDEGDSEVTTMSPPTISRSTTSALAAAVSAPVGAESVQVVAPSPVTLDEYTVPEGTTGDAASVFRLRCRLPHSSSTLQLRPDTPVARLMDYLAYLLYAEDTARYSVPPRISIFSGFPPKNMTAGEMEGVTLSTWPGVRSGDVLMVRVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G1X7</accession>
    <name>A0A836G1X7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03571</name>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="297"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="370" mass="40167" checksum="E54A952532202BFC" modified="2021-09-29" version="1">MITTPADAGSAASAAPAPQQRLFDCLDAASKERVTMLLSHYQVLLPVEQVSFMQELERYNEEQQAAALARGKTGEIWTRYASPRLQAVQARDPAYVQRLISDTSATCGPNGDAAPEEATPSCTLEDLFHTCGIFGEPEGVPIHVGKMSLYEKLRQNMRGRQSTRGQSLITTITMAARAAAEAGADVVDIQASLVDVAQEQAQPVKGDCAMDDHASPKTPTQAEACERALAPMYADALPSDACTTPPIVPYRNNAYQAVRLAMSSPGYIATTPPTSLAEVQSPQDGVKSVLNITAFPITEVKLREWFEELDAQGRGVLSLEEFQHYMRSLERDFGAPGDYAALECDGARLAKSGWLSFEAFAYLVLRFVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836G2J8_9TRYP</name>
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            <fullName evidence="2">Poly(A) RNA polymerase mitochondrial-like central palm domain-containing protein</fullName>
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        <lineage>
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            <taxon>Trypanosomatida</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058615.1">
        <property type="nucleotide sequence ID" value="XM_067202514.1"/>
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    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <location>
            <begin position="173"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="526"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="540"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5464984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="738" mass="79212" checksum="AB8B2897C560A343" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G2M9</accession>
    <name>A0A836G2M9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_00496</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Trypanosomatida</taxon>
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            <taxon>Leishmania</taxon>
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    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="entry name" value="T_SNARE"/>
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            <begin position="379"/>
            <end position="441"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5465044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="471" mass="50449" checksum="B29EAF38234F7E88" modified="2021-09-29" version="1">MDLSYQLWALVEQARCSFTQRPGHTFLVRRKWTAEEEQATESLLTTSKALDDAAAVAICRATAHIAAMMAALDAVTPSSTAHLQNSLLLSDAELLSVSSSLKAFTETLTKVAALTTTQRERGRSGGASLAAGCNDDDFESLSSGNPGAPQVKAESGVVEHLRQSVSILLHRITAKRLHVALAKEELALYKSEMFLYGHCGVLSCSDEVAAELAHDMKMARKEAGLRGQRGNIAAECREADRIPDGVGAPQGRRHSAARTHTDKSGFGTTFRVVDGMMQRAAETFKAAGSHADSALQVALTGSHSAARQLLHVGTSSVAEIFMLGAGPGGGGRADLSRPAPEMFSTTAGVGVAPLPTLQPYQLSPEEEARLQEQNHALLQVQREASAQDAKAVEASIRELSQLTSLMSERVVQQNEQFSLLVKNTEAAQANVQKAVCEVKKPLSVFWNPTRQLVALLWVCTAVLLMANWASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836G4M6_9TRYP</name>
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        <recommendedName>
            <fullName evidence="7">Leucine-rich repeat protein</fullName>
        </recommendedName>
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        <name evidence="5" type="ORF">LSCM4_01343</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
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    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059089.1">
        <property type="nucleotide sequence ID" value="XM_067203398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G4M6"/>
    <dbReference type="SMR" id="A0A836G4M6"/>
    <dbReference type="GeneID" id="92357332"/>
    <dbReference type="KEGG" id="loi:92357332"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454">
        <property type="entry name" value="NISCHARIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454:SF56">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="L domain-like"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="232"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="351"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5466199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="413" mass="44883" checksum="403A1DAA07EBC2D6" modified="2021-09-29" version="1">MDLDFSNRGLFVFDAAKAQSALVDASAAASRTALSTTSADAGDAGGAALPPSALPAIRLLNLSYNSLHLFTGGETLKGLTVLELSHNALTQLYGQSMPPTLVRLSIAYNQLAHLCNLAQYTPRLQVLEAGHNQLSASALRDLPASLTHLSVENNTIESLAPLGTLLRLTHLNLAQNELESRDTLCALRPLVSLRHLDVRGNPMCETGRRSREGEGDGFTELLHDILPRLSRFNGNSLSQAPENRKWKTAHRQQQQQQQQNANFSRGRCRSLPHDARGESGARQRGAREDGSGGSSSSLLSSSERQQHRLQEPSLEVRLMQAKVSELRRLLLAAQDAEGKARQDRALLVENVKSTAIVIDQQEAELGRLQREVESLRDADQKLQLSVAAAEQSFEQVHASLLASKAKLSAPGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G6H3</accession>
    <name>A0A836G6H3_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_01445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059189.1">
        <property type="nucleotide sequence ID" value="XM_067203498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G6H3"/>
    <dbReference type="GeneID" id="92357432"/>
    <dbReference type="KEGG" id="loi:92357432"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="TruD, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001656">
        <property type="entry name" value="PsdUridine_synth_TruD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042214">
        <property type="entry name" value="TruD_catalytic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326:SF25">
        <property type="entry name" value="TRUD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5466299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="612" mass="68523" checksum="C000ECCE70A238CA" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G6M6</accession>
    <name>A0A836G6M6_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059279.1">
        <property type="nucleotide sequence ID" value="XM_067203588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G6M6"/>
    <dbReference type="GeneID" id="92357522"/>
    <dbReference type="KEGG" id="loi:92357522"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="695"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="483"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="556"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5466389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="738" mass="77220" checksum="511C092F02077AE7" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G7E0</accession>
    <name>A0A836G7E0_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_00919</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TPPP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059636.1">
        <property type="nucleotide sequence ID" value="XM_067202986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G7E0"/>
    <dbReference type="GeneID" id="92356920"/>
    <dbReference type="KEGG" id="loi:92356920"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001578">
        <property type="term" value="P:microtubule bundle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046785">
        <property type="term" value="P:microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032273">
        <property type="term" value="P:positive regulation of protein polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008907">
        <property type="entry name" value="TPP/p25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12932">
        <property type="entry name" value="P25 ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12932:SF9">
        <property type="entry name" value="TUBULIN POLYMERIZATION-PROMOTING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05517">
        <property type="entry name" value="p25-alpha"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5467834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="200" mass="21545" checksum="C38DBAB6D8518C81" modified="2021-09-29" version="1">MDSAHFSKMLKECKIIGKCFTSTDADLLFSKVKARDAPNISLASLQDRVLPYISVIIEDAPEYVEVVLAKAAPVSSGIQPENSRLRYGKGSCIGAVTPSVKARDARKISYLEFREKAIPEIAAKMKKSPADIEAMISNAAPMSNGTKADAVRFHDDKSTYTGAAKQGGPTNVDRNPGSLAGVVDRRQETVDNRGTTAKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G948</accession>
    <name>A0A836G948_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_00834</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059556.1">
        <property type="nucleotide sequence ID" value="XM_067202906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G948"/>
    <dbReference type="GeneID" id="92356840"/>
    <dbReference type="KEGG" id="loi:92356840"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035869">
        <property type="term" value="C:ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019184">
        <property type="entry name" value="Uncharacterised_TM-17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13531:SF0">
        <property type="entry name" value="GEO07735P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GEO07735P1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09799">
        <property type="entry name" value="Transmemb_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5467754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="159" mass="17222" checksum="F54F48A5BA52100A" modified="2021-09-29" version="1">MPSSGGTAGGASFPYQLQLLFSIGWASIWWVATLGLLIFKAFHLPFPPAALPMEVVASVLVLIVNAFGVLIGIRGNKTESPSTILISTALLGITTVGAIYYMWLQTYVLMLDLAFSAIYVGINAVGILLGFWATQNVARLARLPSFKLEVEMRKSDKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GAN9</accession>
    <name>A0A836GAN9_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_04685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000023">
        <property type="protein sequence ID" value="KAG5478452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063113.1">
        <property type="nucleotide sequence ID" value="XM_067206666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GAN9"/>
    <dbReference type="GeneID" id="92360600"/>
    <dbReference type="KEGG" id="loi:92360600"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39668">
        <property type="entry name" value="HYPOTHETICAL TRANSMEMBRANE PROTEIN L6586.03-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39668:SF1">
        <property type="entry name" value="T. BRUCEI SPP.-SPECIFIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5478452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="403" mass="41905" checksum="7BE8D3B8F8300835" modified="2021-09-29" version="1">MSLASSCAVLCAPLTAVAAVLLFMMSHMLRHGNWTFEVLAAKHGWEREAKANACMRGGLLYLLTSLVLWLAVLLKAHARRLWMQLQWSRKRGDEWASREALLHGDGESARQAGGRYGRRAVKRPQSRRGSGWREEGKEMSALDWGGQPVTTSCAAAVAGGLLSGADMLSSAGAGSPTAGRFPGFQRNLIDAAGFGSDNSPRFGVDSGSVSTTTPSDTTGVGTVSRVHSRGLRSRGGGSAASSYTAVGAGGVTSSNKIGASAPFAAHTTGADSMDDLDFMSDVEVDGARHYTTPQLRVSGWGLHRSAESAEACGEAVLRGRYRPQARGTGGHTVLVTERGEHGRNGSAEPRTTAALASKLTSLWQTSSTRPSVSEGHGAGDRRAGRGLGPPAASSGGGGKSKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GCL6</accession>
    <name>A0A836GCL6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HORMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_00112</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058303.1">
        <property type="nucleotide sequence ID" value="XM_067202202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GCL6"/>
    <dbReference type="SMR" id="A0A836GCL6"/>
    <dbReference type="GeneID" id="92356136"/>
    <dbReference type="KEGG" id="loi:92356136"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051294">
        <property type="entry name" value="HORMA_MeioticProgression"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48225">
        <property type="entry name" value="HORMA DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48225:SF7">
        <property type="entry name" value="MEIOSIS-SPECIFIC PROTEIN HOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="7">
        <location>
            <begin position="11"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="320"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="523"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5464672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="547" mass="59592" checksum="30BC95FB963BCB19" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GF36</accession>
    <name>A0A836GF36_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP-dependent RNA helicase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_01407</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
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        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="entry name" value="P-loop_NTPase"/>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
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                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="142" mass="15299" checksum="957044D37B4C56F8" modified="2021-09-29" version="1">MGTYLSFPLRKRRRKDSDDSSSAESVSASEAASCPPSSLSRLLLSLRYRCASPSRAGSDVCRCIAEDVATRRTYGCHAHVYETSTADESHGVALAWRVDELVAPLSTLSLLSLCRVANSCRKKTLVTTPNGKAVVLTYTAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GGZ7</accession>
    <name>A0A836GGZ7_9TRYP</name>
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    </protein>
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        <name evidence="7" type="ORF">LSCM4_04050</name>
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    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
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            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <comment type="similarity">
        <text evidence="1 5">Belongs to the heat shock protein 70 family.</text>
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    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG5474871.1"/>
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        <property type="nucleotide sequence ID" value="XM_067206040.1"/>
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    </dbReference>
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        <property type="entry name" value="Endoplasmic reticulum chaperone BiP"/>
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        <property type="entry name" value="ATPase_NBD"/>
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        <property type="entry name" value="Heat_shock_70_CS"/>
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        <property type="entry name" value="HSP70_C_sf"/>
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        <property type="entry name" value="HSP70_peptide-bd_sf"/>
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        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="538"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5474871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="575" mass="62412" checksum="5DCE53DFF968F25C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GHV7</accession>
    <name>A0A836GHV7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LSCM4_01028</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the CEP41 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059744.1">
        <property type="nucleotide sequence ID" value="XM_067203094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GHV7"/>
    <dbReference type="SMR" id="A0A836GHV7"/>
    <dbReference type="GeneID" id="92357028"/>
    <dbReference type="KEGG" id="loi:92357028"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00158">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000123">
        <property type="entry name" value="Rhodanese-like domain containing protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051889">
        <property type="entry name" value="CEP41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44390">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 41 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44390:SF1">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 41 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rhodanese" evidence="12">
        <location>
            <begin position="100"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="217"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG5467942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="249" mass="28483" checksum="7228AECCC854AA29" modified="2021-09-29" version="1">MSINPTIGDKDVLQRRMVANPKYSGVQAVVDSGMTTQLAQYMRNNIIKTRRQPGELFQRLRTDVIAAFLRRQQPKSILQDGGFARPMDEYGGLENALDKLDTGYLLLDCREVEHYHNCHIQTALHYPKMKLHHSTNPFLPEMYAYKNKEKMWIVLYDVEEEAVVHLANTMYQKGIDNVAIIAGGLREFAQDYADLLTAESPVPIITRDLRLRRRAEEVTQARSEARTSMSHKPKSLSSSLARTTRKGTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GJ51</accession>
    <name>A0A836GJ51_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_00249</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058439.1">
        <property type="nucleotide sequence ID" value="XM_067202338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GJ51"/>
    <dbReference type="SMR" id="A0A836GJ51"/>
    <dbReference type="GeneID" id="92356272"/>
    <dbReference type="KEGG" id="loi:92356272"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004838">
        <property type="term" value="F:L-tyrosine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005958">
        <property type="entry name" value="TyrNic_aminoTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01265">
        <property type="entry name" value="tyr_nico_aTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45744">
        <property type="entry name" value="TYROSINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45744:SF2">
        <property type="entry name" value="TYROSINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000517">
        <property type="entry name" value="Tyr_transaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00753">
        <property type="entry name" value="ACCSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="8">
        <location>
            <begin position="45"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000517-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5464808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="432" mass="47457" checksum="CCE38A774BE104A7" modified="2021-09-29" version="1">MARTWDNVKPSTRSQFPHPLLAFGAKLEQIAASNKEKHEAEGKPLLSLAVGDPALDGNIPPPQALTDVIDAIVTEGKSNGYSLSHGTVDVRKAIAEYWMRWFAPSTPGSAISEKDVVISCGCSDGLSMVLGAVAGAGDRILIPEPFFSQYDMNCAYFSIDPVYYPCLAERHWEVDLDALRELVERDHERKIRAILINNPSNPCGSNFSRAHTEAIVKFADEMRIPIVADEIYAGMTYNIDNPSAGVPFTSVADVGTNATRFVVSGASKRFGIPGERMGWIIRVDPTDAGSMIMKGILNLTSRYYIPMTPLQAAMAQCLRTTDESYFSHAKQVLCENAAYMYASLSKIPGLSPMKPEGGMFMSVLLKGEDLDDGLSDGVSFASKLAVEENMHVFPGEPFHMPCAFRLTLSRPLPIAEEAVRRIRAFCERHRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GJB4</accession>
    <name>A0A836GJB4_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_07287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000015">
        <property type="protein sequence ID" value="KAG5483072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064568.1">
        <property type="nucleotide sequence ID" value="XM_067209185.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92363119"/>
    <dbReference type="KEGG" id="loi:92363119"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1070"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1333"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1767"/>
            <end position="1797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2184"/>
            <end position="2214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2441"/>
            <end position="2487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2561"/>
            <end position="2610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2787"/>
            <end position="2826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2874"/>
            <end position="2894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2935"/>
            <end position="2955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3108"/>
            <end position="3129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1784"/>
            <end position="1796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2441"/>
            <end position="2450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2588"/>
            <end position="2597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="2794"/>
            <end position="2803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="2815"/>
            <end position="2824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2874"/>
            <end position="2886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2946"/>
            <end position="2955"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5483072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="3155" mass="332556" checksum="DD63644994AB62C3" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GJG7</accession>
    <name>A0A836GJG7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioesterase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062454.1">
        <property type="nucleotide sequence ID" value="XM_067207151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GJG7"/>
    <dbReference type="SMR" id="A0A836GJG7"/>
    <dbReference type="GeneID" id="92361085"/>
    <dbReference type="KEGG" id="loi:92361085"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00586">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051490">
        <property type="entry name" value="THEM6_lcsJ_thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475:SF4">
        <property type="entry name" value="PROTEIN THEM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13279">
        <property type="entry name" value="4HBT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="303"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5476221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="38097" checksum="12BB2B4BD158AB36" modified="2021-09-29" version="1">MVLAHVLRCQRFLWRGLCDRVRVSKMIGGTLPIPASDATRLVVPVKAIRAAAAKEAAATGAAALHQAPRPRPPRYVWPWLRQLPYDRAFAQFIAQPIVVPVYCGLRMIDAFGHVNNSKYLEICELARWHQLSFLGVGAMMVRRRVAFIVSDLSIIYQREIGPRSTVLVTTRISLPPSSTVYAGQPSSSSIAPPSSESRRVYIEHEVWSQDGRKLHAAVTVAAALIGPVAYEQELARRYEPTTAGSAAAATPSSAGTRARQRTPLNCEYAIADAMGFASVVELRALLDSAEHVCAPIVNDGDTKAPAAAATGEAPDQESAERQERIATLARVWRTSRDRLRHKSLVVPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GJU1</accession>
    <name>A0A836GJU1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_02386</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5468992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059969.1">
        <property type="nucleotide sequence ID" value="XM_067204417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GJU1"/>
    <dbReference type="SMR" id="A0A836GJU1"/>
    <dbReference type="GeneID" id="92358351"/>
    <dbReference type="KEGG" id="loi:92358351"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13156">
        <property type="entry name" value="KOW_RPL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000046">
        <property type="entry name" value="Putative 60S ribosomal protein L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000915">
        <property type="entry name" value="60S_ribosomal_eL6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049633">
        <property type="entry name" value="Ribosomal_eL6_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041997">
        <property type="entry name" value="Ribosomal_eL6_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01159">
        <property type="entry name" value="Ribosomal_L6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01170">
        <property type="entry name" value="RIBOSOMAL_L6E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5468992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="195" mass="21223" checksum="8932ECEC2D4E82A7" modified="2021-09-29" version="1">MAAMTSAVPAIKRKAAKKVSRKSPEYTTLRKSCAPGAIAIILAGRFRGRRAVILKQLPHNGPLVVSGPMKYNGVPIRRIDSRYVIATSTKVDISSVDTSAITPEVFQRPKAEKPAKSEADFMGDKQKAKAEKAAKKTSKAEKKTVVSDARAQLQKKIDAALIAAIKKDAQGKEKAGYLRSVFTVKPGDAPHRWNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GL61</accession>
    <name>A0A836GL61_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_04368</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062562.1">
        <property type="nucleotide sequence ID" value="XM_067206353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GL61"/>
    <dbReference type="SMR" id="A0A836GL61"/>
    <dbReference type="GeneID" id="92360287"/>
    <dbReference type="KEGG" id="loi:92360287"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="582"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="863"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1039"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1108"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="199"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="323"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="406"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="722"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1039"/>
            <end position="1059"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5477151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1184" mass="128410" checksum="327B41C69A5CFA30" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000013">
        <property type="protein sequence ID" value="KAG5484317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="92363694"/>
    <dbReference type="KEGG" id="loi:92363694"/>
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        <property type="component" value="Chromosome 13"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5484317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="298" mass="32216" checksum="9996E01AAFE2B314" modified="2021-09-29" version="1">MPFRGVTVPRAARLPYPPVVLTGRCFLLKPHRHATPVPSSQKDTFLWRDMECVELTPSQSGAGSRRGAVPANLAGNSYYARRYSTQGGARRGSLGATAPHAQFCSGDLVLRLCLSAVPRELAHRRIVDVTGIQTSFHNVSERHSHALATVEEAMHTMHLHDGHEVPALQRGDVNLVRLQPKCVYIPQSPSHSPASGVTAAVDLRHLSSVLRPLSNPDVLLAQARRLSFRSELEAVQTAQVMASFVTELRGGGAVPGDYGTSLTPFSSSAMLRPVVRDGHLVALTLCPPRSAGLGVRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GNN7</accession>
    <name>A0A836GNN7_9TRYP</name>
    <protein>
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            <fullName evidence="1">Trypanosoma Tc-38 (p38) protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_04704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000023">
        <property type="protein sequence ID" value="KAG5478471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063132.1">
        <property type="nucleotide sequence ID" value="XM_067206685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GNN7"/>
    <dbReference type="GeneID" id="92360619"/>
    <dbReference type="KEGG" id="loi:92360619"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045399">
        <property type="entry name" value="Tc-38"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20054">
        <property type="entry name" value="Tc-38"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trypanosoma Tc-38 (p38) protein" evidence="1">
        <location>
            <begin position="28"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Trypanosoma Tc-38 (p38) protein" evidence="1">
        <location>
            <begin position="286"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5478471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="348" mass="39870" checksum="DA008176ED889D67" modified="2021-09-29" version="1">MLRRLSSSALVPRVAAGAVILTADRNIIVFSQQHHILESNQRARNSPSNVWIEDWEAERLGMKPEPGALPTQLVIDKQLELFNFDQLLSPPEVMEAPKHSSYSSRKVYGERLQFELNDRAQRHSYQSKWWITRGQAYKENLQFKANARSSILLTKSQIKLFHSSQLSGGDALQQYPVSGGSRRVYSKKGETFQILQDHIKSNDFNSGLYFTRRQMEFFKLAPLPDQLPVVQEAATGDRHLIYNVDQLEDPHLALKTLQRAPVNVPTFLLSGEPIMSENTRKFPKTFRSNYWLTGRDAELYQWPIKESEKRRGVPFSSGTSSPVQYELFNVEQLSNPDEAFARAGLFIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GPY0</accession>
    <name>A0A836GPY0_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_00892</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Trypanosomatida</taxon>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059610.1">
        <property type="nucleotide sequence ID" value="XM_067202960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GPY0"/>
    <dbReference type="GeneID" id="92356894"/>
    <dbReference type="KEGG" id="loi:92356894"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5467808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="92" mass="9955" checksum="BD017C9CCE9782F2" modified="2021-09-29" version="1">MELREANHLLEELTALLASQESADDDAAVEPVILNAVADYVEGVDPTATGLDRLRKALETAAGEADNSAKQRMKAEGCRRAIKLLYETISQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GSA7</accession>
    <name>A0A836GSA7_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_07730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000006">
        <property type="protein sequence ID" value="KAG5487242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065739.1">
        <property type="nucleotide sequence ID" value="XM_067209609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GSA7"/>
    <dbReference type="GeneID" id="92363543"/>
    <dbReference type="KEGG" id="loi:92363543"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="651"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5487242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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    </evidence>
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</entry>
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                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
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                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
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    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <location>
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            <begin position="55"/>
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            <begin position="243"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="358"/>
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        <location>
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        <location>
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            <end position="1222"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5480354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
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        </recommendedName>
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        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="KEGG" id="loi:92357643"/>
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    </dbReference>
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        </source>
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            <dbReference type="EMBL" id="KAG5466510.1"/>
        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836GYD5_9TRYP</name>
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        <recommendedName>
            <fullName evidence="4">Opioid growth factor receptor (OGFr) conserved domain-containing protein</fullName>
        </recommendedName>
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        </lineage>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="entry name" value="OPIOID GROWTH FACTOR RECEPTOR (OGFR) CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
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            <end position="95"/>
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        <location>
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            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5476117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="402" mass="44096" checksum="330BC34DA9FB9DF9" modified="2021-09-29" version="1">MEAQQQQYYCEALAADGAADGDKQGGQRRVDGDELHPSVRFYRGMWNLTQLSDPIFDDVPSNTDGSNGDKTASAQAPATLPAVPSGSPSPTPRSSRLSIVGLHQALLPPATVSGAADVAEENYAVQLASSDGLELLRLHWHVLLPLLFPCCRWGDQASANVPGVLRSLRGSCSGAAEENAPSSLPEQQGCSVTEDGPSAPAESAWSATELYELLLHRPLMENDLATIREPGLMDRVYYSYVVLLRFFGWRVYEEERGLLDRHRAWQERYALLELYRTSAVVTLTASGEAGTMTAASLSHADHGSATKGGARPPPPPTYRAFNFYESGVPRVLRCLLDIGFLRLAVRLVEFLLEEMDNGRLLFLLPLVETTLLPTVVQHSNVESSHKARLRKRLYRLKHSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GZZ8</accession>
    <name>A0A836GZZ8_9TRYP</name>
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            <fullName evidence="10">Intraflagellar transport complex B protein 46 C terminal</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_02096</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IFT46 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061169.1">
        <property type="nucleotide sequence ID" value="XM_067204132.1"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A836GZZ8"/>
    <dbReference type="GeneID" id="92358066"/>
    <dbReference type="KEGG" id="loi:92358066"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022088">
        <property type="entry name" value="Intraflagellar_transp_cmplxB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13376">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 46 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13376:SF0">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 46 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12317">
        <property type="entry name" value="IFT46_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="51"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="116"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5472773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="461" mass="50298" checksum="DDBD06B0F7E0ED7B" modified="2021-09-29" version="1">MHHALGEGSNASDYDEGTEATKEKVSESGSELSRRSGDDLPVPASGYLLQSPPTVNSPTRDRVNSAQLTSSNSADITSQAYNSGSGRPLQGLTASAMENPSESAVLGGQLMTNNPNDERIEVPDAENVKTPRTSLRPSYAPDTDESRGGGAMGQPIENAPHDEAIPVSPSASQVATPMAMRAGQAMRPDDDDDDTEDEGEEAAEEEEDTELDENHEYRAEGYAGQKPTDLAEAASAMHGSDLQLGYNPAKYARINATASNEMQELFKLITKYEPFAAELPAKLRPFVPDYIPAIGDLDPFVKVPRPDGIPDGLGLEMVDEPAIPQSNPAVVLLELNATNAHGVSADVVDSLENAANRPEVIDRWISDIKKVHYKKALPTVNYQRPMPEIETLMQVWPQQFEEVLNSDFTFPPSNISLDLDQYVRTLCAILDIPTYSSLIDSLHVMFTLYEEFRSNQHFQHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H0R2</accession>
    <name>A0A836H0R2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tetratricopeptide repeat protein 29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_04550</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">LSCM4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062743.1">
        <property type="nucleotide sequence ID" value="XM_067206534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H0R2"/>
    <dbReference type="SMR" id="A0A836H0R2"/>
    <dbReference type="GeneID" id="92360468"/>
    <dbReference type="KEGG" id="loi:92360468"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051476">
        <property type="entry name" value="Bac_ResReg_Asp_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46630">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46630:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5477332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="481" mass="52867" checksum="30610711186E9BF5" modified="2021-09-29" version="1">MQSAPSPVPQKRAAVAGRLGKPGSGGSCAESNRPQPIDSFAKVTLPGMPGRHCTAVVRGQSPQLSHHADRKGHDEPLLDSRASQEGITGAAAFTKKRNAARTKVVDDAHAPIVVVGPERDSAPFRLCCEALAEGCVQTYMHLFELAHRSPVCVDTLSRKFFSVPDDRLAWVQQQLSAVEVLRRQSEFEQVLAHCRNLADYFDGEGDYAEAAWYHETALQYMMESLDRTLEQSAREAYAAFQERHGHLEEAAALYEAMHRLAVALRDERALQAASGCLLRIYQTLGDAVKFSDPTVAASYYAKAAEVAERSKNGLGEGTAYSALGDVSEARGDLPLALKYQRSYRIVAHQNDLKPQECHATLRVADLEERLGLKLEASTTLQEALQLAKELGAPRQLCIATMQLGEAYRIRDQEYQALQCFEESFAAAMEAKDQELIDTVRIAMGFARGDYHLTHAYGGQGYLHLVCTDIRAQLAWMSGGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H0T0</accession>
    <name>A0A836H0T0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_04581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062773.1">
        <property type="nucleotide sequence ID" value="XM_067206564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H0T0"/>
    <dbReference type="SMR" id="A0A836H0T0"/>
    <dbReference type="GeneID" id="92360498"/>
    <dbReference type="KEGG" id="loi:92360498"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050871">
        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="1">
        <location>
            <begin position="336"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5477362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="436" mass="49201" checksum="51D93951A5492F28" modified="2021-09-29" version="1">MEDVYYYDDGDYDEYYDSGADEVADVSPLEVKYVDGKSFMQSNVEESLRCLQEVVAEDSEHGRWTFKALKMLARASRIAKLFDAMVDYYTQVVHFAHPNVDAAAVAKAMLKFSEESQRVPAEWRGRTLHVTLEVATAQPDSYRDVIVPTLLRRATLFIEEAKYEEALVDLQAALRQCDKSSANVAQVNATSVYHIRTLQLTAYRKLSRYTELRRAYYELGRVHAALPSLRMIGSAMESAGHMFLHDADWAAAHRAFSSALRCHTESGDVQQYNVVKYVVLATIMAGLPADVFAQEETLANHPSVRPVRALWQAFVEMDVPTFLQVLHAPDSVACFEKDAEFAPYVEPMMFQLRTNYLISYSKSFGTLSLEELGARLRLQEQPCKELCTSAILLGLIDARVDDARKLLLFQRAPRTVPSSVAVLRDLSVMTSELCCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H1V7</accession>
    <name>A0A836H1V7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nodulin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_06007</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000011">
        <property type="protein sequence ID" value="KAG5485371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065108.1">
        <property type="nucleotide sequence ID" value="XM_067207934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H1V7"/>
    <dbReference type="GeneID" id="92361868"/>
    <dbReference type="KEGG" id="loi:92361868"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010658">
        <property type="entry name" value="Nodulin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576:SF157">
        <property type="entry name" value="NODULIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576">
        <property type="entry name" value="UNCHARACTERIZED NODULIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06813">
        <property type="entry name" value="Nodulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="447"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="481"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="511"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="541"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="579"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="Nodulin-like" evidence="7">
        <location>
            <begin position="42"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="310"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="638"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="644"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="656"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5485371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="673" mass="74371" checksum="7FE923A1CACA90BE" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H1Z5</accession>
    <name>A0A836H1Z5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RCC1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_05056</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062333.1">
        <property type="nucleotide sequence ID" value="XM_067207030.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836H1Z5"/>
    <dbReference type="GeneID" id="92360964"/>
    <dbReference type="KEGG" id="loi:92360964"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051210">
        <property type="entry name" value="Ub_ligase/GEF_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF466">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="RCC1-like" evidence="5">
        <location>
            <begin position="593"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="612"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="785"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="837"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="981"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="1042"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="1095"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="1151"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="441"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="531"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1316"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1365"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1634"/>
            <end position="1680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="348"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="450"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1412"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1641"/>
            <end position="1650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1665"/>
            <end position="1676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5476100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1731" mass="181050" checksum="15438BEB4F6DEB95" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H3A1</accession>
    <name>A0A836H3A1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">carboxypeptidase Taq</fullName>
            <ecNumber evidence="8">3.4.17.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_02581</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Release of a C-terminal amino acid with broad specificity, except for -Pro.</text>
            <dbReference type="EC" id="3.4.17.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the peptidase M32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.17.19" evidence="8"/>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060160.1">
        <property type="nucleotide sequence ID" value="XM_067204608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H3A1"/>
    <dbReference type="SMR" id="A0A836H3A1"/>
    <dbReference type="GeneID" id="92358542"/>
    <dbReference type="KEGG" id="loi:92358542"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06460">
        <property type="entry name" value="M32_Taq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1370.30:FF:000003">
        <property type="entry name" value="Thermostable carboxypeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001333">
        <property type="entry name" value="Peptidase_M32_Taq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34217:SF1">
        <property type="entry name" value="CARBOXYPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34217">
        <property type="entry name" value="METAL-DEPENDENT CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02074">
        <property type="entry name" value="Peptidase_M32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006615">
        <property type="entry name" value="Zn_crbxpep_Taq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00998">
        <property type="entry name" value="CRBOXYPTASET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52034">
        <property type="entry name" value="PEPTIDASE_M32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00052755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00061580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00066553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006615-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5469183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="499" mass="57506" checksum="E7E3305CCC76D93D" modified="2021-09-29" version="1">MEAYKKLETVFTKIYRLDHFISLGDWDMNTNMPPKGEDARGEAMAMLSEIRFGFITAPEMKELIESATKRREELDKMQRANLREMTRAWKSATALPAEFVGRKMRLTTRAHSVWRDSRAANDFSKFFPVLKDLVALAREEGSYLAAGTSLSPYEALMDQYEPGITTQRLDEVYANLKSWLPQLLKDIVQKQSGDSVIEFSQKFPQDKQEALCKEFLRIWHFDTDAGRLDVSPHPFTGMTKEDCRLTTNYVEETFVQSLYGVIHEGGHGKYEQNCGPREFITQPVCNARSLGLHESQSLFAEFQIGHATAFIDYLTSRLPEFFEPQLALSQENMRKALQRVRPGYIRIDADEVCYPLHVILRYEIERDLMEGKMEAEDVPRVWNEKMQAYLGLSTEGRDDVGCLQDVHWSMGSLGYFPTYSLGAMYAAQIMASIRKELGDDQVDHCLRTGELRPILEKLKEKIWDHGCLYETDELMTRATGETLNPEYLRRHLEARYLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H4N3</accession>
    <name>A0A836H4N3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_03045</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="4">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="4"/>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060616.1">
        <property type="nucleotide sequence ID" value="XM_067205064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H4N3"/>
    <dbReference type="GeneID" id="92358998"/>
    <dbReference type="KEGG" id="loi:92358998"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="134"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5470350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="692" mass="77901" checksum="F5B2EE925B24AD7E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H5Y1</accession>
    <name>A0A836H5Y1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000011">
        <property type="protein sequence ID" value="KAG5485379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065116.1">
        <property type="nucleotide sequence ID" value="XM_067207942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H5Y1"/>
    <dbReference type="GeneID" id="92361876"/>
    <dbReference type="KEGG" id="loi:92361876"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5485379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="21723" checksum="301EF3767F51C9DC" modified="2021-09-29" version="1">MATADQLRYAAQLIELARGEETEDGNPLTAVRHYTTAMEIIASEASKRAATISSGEARRFFLFQIRSKLEMYYERAELLLQVANGSGLLDKPNLSSGDALAFQASHPPALFTSTVASEMNNSDSGGAGVHAAGGGGSVLGIPLQSQQANHPAPPAHAQSDYDDSREPPMSCYLKHDDDGTSAPPPVMPEMDLDELLRNLGAPPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H604</accession>
    <name>A0A836H604_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Guanine nucleotide-binding protein subunit beta-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_04297</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062221.1">
        <property type="nucleotide sequence ID" value="XM_067206284.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836H604"/>
    <dbReference type="GeneID" id="92360218"/>
    <dbReference type="KEGG" id="loi:92360218"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:002190">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052993">
        <property type="entry name" value="CFA-57"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32215">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32215:SF0">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="625"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="914"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1455"/>
            <end position="1547"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="990"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1213"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1276"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1462"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1472"/>
            <end position="1481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5475713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1595" mass="174233" checksum="40629D75A1BBC3A1" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H7H2</accession>
    <name>A0A836H7H2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TATA box-binding protein-like 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">TBP-like factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_06518</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000019">
        <property type="protein sequence ID" value="KAG5480947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063948.1">
        <property type="nucleotide sequence ID" value="XM_067208436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H7H2"/>
    <dbReference type="SMR" id="A0A836H7H2"/>
    <dbReference type="GeneID" id="92362370"/>
    <dbReference type="KEGG" id="loi:92362370"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04517">
        <property type="entry name" value="TLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000022">
        <property type="entry name" value="Transcription initiation factor-like protein (TFIID-like protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000024">
        <property type="entry name" value="Transcription initiation factor-like protein (TFIID-like protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015445">
        <property type="entry name" value="TBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5480947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="291" mass="31188" checksum="C8521628A18E4E76" modified="2021-09-29" version="1">MDDDYAFFESDNMVEEDPPVIGAFPDSVVQFGGDLGPTGAIGDATLTADGHLTAATLPGGDGAAFNLDADELPPPITNVQEFLPNVHPDAFPVVVAVQAQASIPVGINLAELSCATRNVEYMPNNRIPSATMRLHEPTAVVMMHNSGALSIIGAASVSEARQAAELAARIIRKALNIDFSSLKFRVRSIAARFNVCSPIRLDKLAAYKLDPAMSIGVAKLQVNYEPERFNGCVLRLVGKSSRGDNQWSVSCSVFVTGKVQLMGARSMDELRFAFNAFVPIIAKHLDERKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H882</accession>
    <name>A0A836H882_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Heat shock 70-related protein 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_02166</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061237.1">
        <property type="nucleotide sequence ID" value="XM_067204200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H882"/>
    <dbReference type="SMR" id="A0A836H882"/>
    <dbReference type="GeneID" id="92358134"/>
    <dbReference type="KEGG" id="loi:92358134"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000014">
        <property type="entry name" value="Chaperone protein DnaK HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000020">
        <property type="entry name" value="Chaperone protein HscA homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000026">
        <property type="entry name" value="Heat shock 70-related protein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000003">
        <property type="entry name" value="Heat shock protein 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000004">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000003">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="625"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="272"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5472841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="661" mass="71527" checksum="B517F72C0B3569EA" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H8L7</accession>
    <name>A0A836H8L7_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_06299</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Bates M.D."/>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Bates M.D."/>
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</entry>
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                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
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        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
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                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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</entry>
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                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
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                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="term" value="C:protein phosphatase type 2A complex"/>
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        <property type="term" value="F:protein phosphatase regulator activity"/>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ARM-type_fold"/>
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        <property type="entry name" value="HEAT_type_2"/>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HIG8</accession>
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    <reference evidence="3" key="1">
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                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG5486827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067208216.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="611"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="482"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="614"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5486827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="652" mass="67602" checksum="27EA7C31057009EA" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HJE2</accession>
    <name>A0A836HJE2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cullin family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_05661</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000016">
        <property type="protein sequence ID" value="KAG5482403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064409.1">
        <property type="nucleotide sequence ID" value="XM_067207595.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92361529"/>
    <dbReference type="KEGG" id="loi:92361529"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031461">
        <property type="term" value="C:cullin-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Cullin family profile" evidence="6">
        <location>
            <begin position="1777"/>
            <end position="2056"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="258"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="364"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="485"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="659"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1017"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1381"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1455"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2111"/>
            <end position="2149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="266"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="391"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="412"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="434"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="491"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="502"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="530"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="684"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="735"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="768"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1017"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1090"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1101"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1112"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1478"/>
            <end position="1487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5482403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="2239" mass="236022" checksum="3C7980C3F8B052D0" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HJN4</accession>
    <name>A0A836HJN4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nucleobase transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_05991</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000011">
        <property type="protein sequence ID" value="KAG5485355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065092.1">
        <property type="nucleotide sequence ID" value="XM_067207918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HJN4"/>
    <dbReference type="SMR" id="A0A836HJN4"/>
    <dbReference type="GeneID" id="92361852"/>
    <dbReference type="KEGG" id="loi:92361852"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002259">
        <property type="entry name" value="Eqnu_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332:SF10">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01733">
        <property type="entry name" value="Nucleoside_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="398"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="460"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="529"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5485355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="553" mass="59822" checksum="48247ABF613B998E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HJY6</accession>
    <name>A0A836HJY6_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5478033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062940.1">
        <property type="nucleotide sequence ID" value="XM_067207372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HJY6"/>
    <dbReference type="SMR" id="A0A836HJY6"/>
    <dbReference type="GeneID" id="92361306"/>
    <dbReference type="KEGG" id="loi:92361306"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5478033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="200" mass="22888" checksum="AD25087924C38664" modified="2021-09-29" version="1">MSEVTAFSAYQTRSTLLMERERAMDVRRAAVAELRQMVATLTSENRTREEHLVSERSRFRDRKSAQDAKVSAKEAEARAQQSRVSVLEEEERQLSSTIAERAEEMRTAAAEVERRRDLEATLREAREVLKKAKFALEENDAKVMRLETRLARQELATDKRHAQLAGCVPQYWFPRVPEADKTASLEDTAGESVYLVDELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HKC4</accession>
    <name>A0A836HKC4_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_06658</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000010">
        <property type="protein sequence ID" value="KAG5485700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065284.1">
        <property type="nucleotide sequence ID" value="XM_067208573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HKC4"/>
    <dbReference type="GeneID" id="92362507"/>
    <dbReference type="KEGG" id="loi:92362507"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5485700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="425" mass="47370" checksum="19C90C03E24A7990" modified="2021-09-29" version="1">MSENRELLKGLEDKPHHITIPLEDWHHLTIGKCKAFCYRYGVSANEVIQQLRSGDRENRTFPIKHLFPLFVSREELQQAEKLGQIAKERNLNVKYLSACRQRLLNGSAPVHSATLSAVPPARRLDIDGALAQVLATRSTLCFGLHLLVSVQNDDAEQQSAPTALADATVRAHLERLPLAVLHRLLSELCEVRAAWLRDLLAPSAAAAAQEQALLDREAINALLYHVCLWQRRYPLELVSATLAFYDDNKQLFSPATPASPSTSAQLESLLEEVHCLHYPDLRDVPGLIRCDVLMTYPHMPAEEQQQLMRNIAVAVAHRKPTGRPQHQSDSEEVDEGGVAGNLLRHSRTPLDPRLFLRPFVAEGAAAIPGRFCNIMSTEKYHAMRAAFELHKHDGVRRLAAQDYGETSAYLTPLPPHLSATSSLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HN57</accession>
    <name>A0A836HN57_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit H</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_05868</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase H subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063571.1">
        <property type="nucleotide sequence ID" value="XM_067207798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HN57"/>
    <dbReference type="SMR" id="A0A836HN57"/>
    <dbReference type="GeneID" id="92361732"/>
    <dbReference type="KEGG" id="loi:92361732"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.150">
        <property type="entry name" value="V-type ATPase, subunit H, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004908">
        <property type="entry name" value="ATPase_V1-cplx_hsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011987">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038497">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11698">
        <property type="entry name" value="V-ATPase_H_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03224">
        <property type="entry name" value="V-ATPase_H_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF032184">
        <property type="entry name" value="ATPase_V1_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase V1 complex subunit H C-terminal" evidence="6">
        <location>
            <begin position="359"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR032184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF11698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5479860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="483" mass="54137" checksum="D47AF5A957D90066" modified="2021-09-29" version="1">MPALSADAADTVSLVRQLQLLDDTTIRLLEQLFTNRLDEELVASLVGGREESLAIALFRLCAGTHAEHILGYALRFLADLVYADHEIGVQLGRDELQKHFGGHPASLLLQIASSHSERLGIANPAIYLAATALRYGNYEGNESAFADFFALARHTFAPETLQVADVEFTVQACVQLARRKDFRPLFFTENLVSSIPHLLTDIVSSDSAGIIQIIYETLLLAWLLSFEYEGLVLLVRERMIPQLHRVLQRVQKEKCVRVTLMTLLNMVEAERKYMNKLLNPSSDEWVDSSIYALGRLHQGETTEQKLSTFKKGPSLVAEMVSVGMIKTLSQVSRRKFGDEDINMMVDQLNSALEKSMQVLTSFSQYRGEVLSGVLEWTPVHTSTKFWKEKAVKVEDNGYEVLLALGKVLRESNNEVTLAVGCHDLGEIIRYHPAGRNLLSLVAMAGVKERVMTLMSHSNPEVAKEALLCTQKIMVQRWEFMQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HPC0</accession>
    <name>A0A836HPC0_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_07556</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000004">
        <property type="protein sequence ID" value="KAG5487875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066072.1">
        <property type="nucleotide sequence ID" value="XM_067209440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HPC0"/>
    <dbReference type="GeneID" id="92363374"/>
    <dbReference type="KEGG" id="loi:92363374"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5487875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="513" mass="55400" checksum="FC7DAC2349DC51E2" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HPR6</accession>
    <name>A0A836HPR6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LSCM4_06995</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000017">
        <property type="protein sequence ID" value="KAG5481916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064276.1">
        <property type="nucleotide sequence ID" value="XM_067208902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HPR6"/>
    <dbReference type="GeneID" id="92362836"/>
    <dbReference type="KEGG" id="loi:92362836"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008331">
        <property type="term" value="F:high voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050599">
        <property type="entry name" value="VDCC_alpha-1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628:SF7">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="3" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="503"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="589"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="632"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="661"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="796"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="826"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="884"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="934"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1003"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1042"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="15">
        <location>
            <begin position="60"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="15">
        <location>
            <begin position="473"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="15">
        <location>
            <begin position="796"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="380"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="380"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG5481916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1185" mass="128840" checksum="8CB34F388E85AD8E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HR19</accession>
    <name>A0A836HR19_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cilia-and flagella-associated protein 96</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_06709</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CFAP96 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000009">
        <property type="protein sequence ID" value="KAG5486003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065334.1">
        <property type="nucleotide sequence ID" value="XM_067208623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HR19"/>
    <dbReference type="GeneID" id="92362557"/>
    <dbReference type="KEGG" id="loi:92362557"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029358">
        <property type="entry name" value="CFAP96"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31144">
        <property type="entry name" value="UPF0602 PROTEIN C4ORF47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31144:SF1">
        <property type="entry name" value="UPF0602 PROTEIN C4ORF47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15239">
        <property type="entry name" value="CFAP96-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5486003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="306" mass="33490" checksum="090F2CFD6D360CB6" modified="2021-09-29" version="1">MFSPPVYLSVGDEYDKRDGTASKATGQPPFVVSTRRSPHITDATFDPLVPLSNGDPYRSVGFTGPFRQSLSPRGRTGPDGGAAAPPPFRPTGASKKSSGKGDYYGTFYEKAPIRHETEFPPIKTAADYKAETAAAKRNFIVNPPKKGTYGYPGLTIAQAGEVQYVSDPYEGKMRREALQSKYEAAKHVGAPFRSALHSGGCFDESEHGVSRVYSLTKPLPPKRILSSQQTISGTAAGRKPWVPGGALVPDLLKQPEYQEDPYDVKERKVRAMRLKESTYKPWVPAGNDPYRFIYTKPIAYDPPAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HU47</accession>
    <name>A0A836HU47_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphatidylinositol 4-phosphate 5-kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_08113</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
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            <taxon>Metakinetoplastina</taxon>
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                <person name="Gatherer D."/>
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                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5486058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="666" mass="71142" checksum="F40610C79EFFFF4D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836K6H9</accession>
    <name>A0A836K6H9_9TRYP</name>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067202444.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="loi:92356378"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5464914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="110" mass="11520" checksum="34A2A04C8A655CB4" modified="2021-09-29" version="1">MNVTAGVSETPACGDAGAVVEINSLQPAPHRSHSAHAPAPTDAALCLQQLDEDVARDVRAAQARAAILQEEVNSLLTRVAHAHDAATVGRQDGRDAVLERVKAIRQARGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836K6Q8</accession>
    <name>A0A836K6Q8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flagellum targeting protein kharon1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_00622</name>
    </gene>
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        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058800.1">
        <property type="nucleotide sequence ID" value="XM_067202699.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="92356633"/>
    <dbReference type="KEGG" id="loi:92356633"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
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        <location>
            <begin position="394"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5465169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="508" mass="56499" checksum="0B0A1E0014C98BD8" modified="2021-09-29" version="1">MTREVTSTQHSEPAYMSARQRARKNVSGENAARVIMGMDLVSEDAERRPSHGRQRSNVPRNNFSSPIEFFAGPRQPPRQQTGVRRNPNSNQDSVGVMLRDEYFMMDHDANNANARRGARRSSSKYGARGSGSGFSLMAYGLQARRGEGTARQKNALLQNRKSGFANGATSPYRCRDGLTNNCIVTAPEAPWRCGVRITHPQGPMDAPFFEDNDPRPPREVPAVTGKRHVKPPHKDAKMFGQVQPLKEGEEDYEASLPPCHKTSNKANESVDVLNLYCYTPEELNEKPVPYKQLGPRTFCAPDMPPRKPAKIKPINTPAKQEHDVLGTGRWGVPEQPHPRGLARGLCRPPRDTANLFYGGTSDAEETNSSPARDNSSVGRGGTQSVRADARQPRQVDSQRSTSITSSQGPRRVDAKGQSSRAGGPKKREDPVFDENYRPRVKVFRRYSGDVNLLRYYDPCVDPVPAAPPRRPYPRSNMESTLDDSNMPRNHGRARGEFCINSRSTLVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836K7I5</accession>
    <name>A0A836K7I5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">LMBR1-like membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_01191</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058944.1">
        <property type="nucleotide sequence ID" value="XM_067203253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836K7I5"/>
    <dbReference type="SMR" id="A0A836K7I5"/>
    <dbReference type="GeneID" id="92357187"/>
    <dbReference type="KEGG" id="loi:92357187"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006876">
        <property type="entry name" value="LMBR1-like_membr_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31652">
        <property type="entry name" value="LIMR FAMILY PROTEIN DDB_G0283707-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31652:SF0">
        <property type="entry name" value="LIMR FAMILY PROTEIN DDB_G0283707-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04791">
        <property type="entry name" value="LMBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="311"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="411"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5466054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="448" mass="49483" checksum="AD9A8B49DCFDF1D0" modified="2021-09-29" version="1">MFVVDWIAAGIVAALVLFLSVHAVCRFSAEEEDGDAWLPRLLVIVTLCVACYMVLLLPLEVALTSDRPSLDFVWAWKGMMIAAYFLLFVGGPFAIVFYESWSPTQSSVWAQVRPSLVAVVTANVAFAAAFGTLWQWGDHLDTKEGTLTHVPPFVYFVATASSFGWCFFFVFAGVGLAAVPLRAVAAFVNRPRAITKVEYDLTRAKLSLEVQHLLDAGRRLDAQVGVGRPDHKQCQRILLFRRKVRDVERQSERNEAAYHLSGACILRCYMAASIGVVNGIVTLLWVLHILLSNILNAFPLMDLMICFLNDLLPMLATLVYAYCAMYLMWCTVVGCRSVSGHVLVLPVYPLRVRGTMLNALLFNAMLLLCSAFAVLHLCTVSFSTYAASTFVHNVFAVTLPHMFGVKYVAQGLQYALLAVFSLSIPWLAVRPLCVSSVVSSEDEDDGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836K7N6</accession>
    <name>A0A836K7N6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL18 C-terminal eukaryotes domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_01364</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059109.1">
        <property type="nucleotide sequence ID" value="XM_067203418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836K7N6"/>
    <dbReference type="SMR" id="A0A836K7N6"/>
    <dbReference type="GeneID" id="92357352"/>
    <dbReference type="KEGG" id="loi:92357352"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00432">
        <property type="entry name" value="Ribosomal_L18_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.100:FF:000002">
        <property type="entry name" value="60S ribosomal protein L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_A">
        <property type="entry name" value="Ribosomal_uL18_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005485">
        <property type="entry name" value="Rbsml_uL18_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057268">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025607">
        <property type="entry name" value="Ribosomal_uL18_C_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410:SF12">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410">
        <property type="entry name" value="RIBOSOMAL PROTEIN L5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14204">
        <property type="entry name" value="Ribosomal_L18_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17144">
        <property type="entry name" value="Ribosomal_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00058">
        <property type="entry name" value="RIBOSOMALL5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL18 C-terminal eukaryotes" evidence="7">
        <location>
            <begin position="245"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="256"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5466219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="305" mass="34057" checksum="BD357779CF40A631" modified="2021-09-29" version="1">MPFVKVVKNKAYFKRFQVKYRRRREGKTDYHARRQMVLQDKTKFGSPKYRLVVRITNKDIIAQIVQAKIVGDEVLMAAYAHELPAFGIEHGLTNYAAAYATGLLLARRTLTKLGIADKFQGAKEADGSYSAVRTKKDDQGDDEERFPFKAILDVGLARTTTGARVFGVLKGAVDGGIAVPHRPNRFPGYNKEKSSLDAKVHRDRIFGRHVAEYLKQVKEEASSNPDEKCVQFSKYMSAKVAPESIEGMYKKAHAAIRADPSKSLPKKAKKEGGEHKSYKAKRMSGAEKRAAAKAKVAAIRQRLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KBF4</accession>
    <name>A0A836KBF4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_02964</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060535.1">
        <property type="nucleotide sequence ID" value="XM_067204983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KBF4"/>
    <dbReference type="GeneID" id="92358917"/>
    <dbReference type="KEGG" id="loi:92358917"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06127">
        <property type="entry name" value="DEDDh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30231">
        <property type="entry name" value="DNA POLYMERASE III SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30231:SF4">
        <property type="entry name" value="PROTEIN NEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="5">
        <location>
            <begin position="154"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="11"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5470269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="395" mass="42953" checksum="9F921F1CD30DF5AF" modified="2021-09-29" version="1">MDDLSARIRRLRGRQPQRRSRPYTVARENSSSGKTRPKSTVTSLSTTRSVVALVKEWTSGQGLRELHQTPTAVPLSSGFTHLSASSRRLAVSAPCNVGCERGAYGSPFAPVTPKVLPLLADTIGLRAPRQGDEAPASSLISCSSTPVLGSAPFSCVVIDLETTGFSAVADEILEVGCVELRWTPPSRTASTGPKHVAPDAPSLEKRSVCDVVEGLWTRGGRVFHRYVRPSNPRRIPAAATAVHGITWEMVQHCAPWPVVASELAAYLALIRADTLATTPAPPETAQLGRHRALHLPPLVAHNALFDARFLEQHLWRCGYQIFWHPQYPLTCTREWAHVAFPHLASNLDALCQFLSIDGVADRAANGHGALTDATMTALLFLRMCRLWTQRFGGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KCZ1</accession>
    <name>A0A836KCZ1_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059155.1">
        <property type="nucleotide sequence ID" value="XM_067203464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KCZ1"/>
    <dbReference type="GeneID" id="92357398"/>
    <dbReference type="KEGG" id="loi:92357398"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5466265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="493" mass="55045" checksum="90F89C9550455CED" modified="2021-09-29" version="1">MRRVTRVVGAFVCRGCCSADQGELQIRRSTPSSTPFLTVRLCSSLPSSLPLPPVSSPALLTDEGELGAGGKGRPTSVKERDSSGPAPMSNLSSVNAAEDFTEQIFETPGYSAEDAFGHSDPLKAVEHALRTGRKVSASDAASGHGTRTSESAALPAVDSTAGSAANPALDTDVAKEIDPVASNRNRRRNRRKRTADAILGDVLHDALLLRDMGEKPTADFVYKRTRERMYEAEYGRKPPSARENAAKLIPFPPDFRLHRLLPLFEERGDDAVESAPTDSPSYGATRPAAPARVYTKNYMNTYALLPPDPWPERAVTPDNPVWTRREVDADREKTGGRGLKEWEDRMYGPRPGYEVHGEFLDAMDELGHWEVQLIHFLRVVPLSQRRSLPFLHEWYRLLVHRVLRAERRYIRIRDVALANSNASTALFKRTEQLIDNVRSYYAEAHRSLASANYDPLRMKKSALAPLMRMTDKEFAEWQEVQRQRRNALAAELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KF06</accession>
    <name>A0A836KF06_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Complex 1 LYR protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_02906</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060478.1">
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        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
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        <location>
            <begin position="10"/>
            <end position="65"/>
        </location>
    </feature>
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        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5470212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="206" mass="24022" checksum="F0CE2715CE211B2B" modified="2021-09-29" version="1">MSALVPCDAVALLYRRYLKAANRIPNVTIRMLLLQQIRSSFRRNRSITSASAQRELINQAHKDLAVLEDDRLSRTLYINRLGLVSCLDWEVRRTEYNFRPETQSYLAVLLICGFSLLFMVFLHTEKIETRRPDIAQMVDYMAMRLEAASPEELKEARERQIRNSLEQRQHQLSVEQRVLATFYNAPNAPAPSLRNPEGSLRYERHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470075.1"/>
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    </dbReference>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
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        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="530"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5470075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="556" mass="59208" checksum="B41070492D57761B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KGV2</accession>
    <name>A0A836KGV2_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    <organism evidence="2 3">
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="32"/>
        </location>
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        <location>
            <begin position="695"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5475609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1011" mass="109196" checksum="F61CBEAF1ED6FD05" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KHV4</accession>
    <name>A0A836KHV4_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    <gene>
        <name evidence="2" type="ORF">LSCM4_03440</name>
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    <organism evidence="2 3">
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        <lineage>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473377.1"/>
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    <dbReference type="PANTHER" id="PTHR34496">
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        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5473377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="447" mass="48347" checksum="3CA31C57FE3204B1" modified="2021-09-29" version="1">MQPRALWSRRSRAARFASRTLFLSAVCIGALVLLSGVFIWRATDSWAEGARVGGKWTPPFLTPGNPAGLLVPGAGTDALDSGAQPLTGHLEAAPYTESLEELLRLLRIYAEHRGVRVNHTYSAPLEAAAALAGISDGGNSSHRGAEVGGAVLQLRGVKLLHDFHGDGGQVVGHLSADWVLDDPETIMAEQETYVERYLVPTQTEVELTPLRVISSYYDTKGSRSLDRMAAETEKAMSDDGYVTYIHRSPTFYDVSHAARRGYGQEGSIFVAVPFTLTDITSEMVDTIRRRALTASTSPKSTHPGSNATLRVGDDFVGDDGFKELRLTAARCAMTVESLFRQAHRGVAVTIGSMDVVVVSGVSTAADVIFPLRAADRGAATLSRRRRYSRITCEPPDFTSDWDDADYGFRWKDNLHRRRVVVPLTALDGAAGTGPTLLQVKDVAAAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836KI46_9TRYP</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059353.1">
        <property type="nucleotide sequence ID" value="XM_067203662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KI46"/>
    <dbReference type="SMR" id="A0A836KI46"/>
    <dbReference type="GeneID" id="92357596"/>
    <dbReference type="KEGG" id="loi:92357596"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="646"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="726"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="803"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="691"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="726"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="737"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5466463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1066" mass="115548" checksum="9DD0821669437A90" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KI49</accession>
    <name>A0A836KI49_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060692.1">
        <property type="nucleotide sequence ID" value="XM_067205140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KI49"/>
    <dbReference type="GeneID" id="92359074"/>
    <dbReference type="KEGG" id="loi:92359074"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140284">
        <property type="term" value="C:endoplasmic reticulum-endosome membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055777">
        <property type="entry name" value="DUF7353"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053012">
        <property type="entry name" value="ER-organelle_contact"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46384:SF2">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46384">
        <property type="entry name" value="MOTILE SPERM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24044">
        <property type="entry name" value="DUF7353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="64"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5471575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="988" mass="110252" checksum="295CF82C13A07A58" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KJF6</accession>
    <name>A0A836KJF6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HpcH/HpaI aldolase/citrate lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_05437</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5478039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062946.1">
        <property type="nucleotide sequence ID" value="XM_067207378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KJF6"/>
    <dbReference type="SMR" id="A0A836KJF6"/>
    <dbReference type="GeneID" id="92361312"/>
    <dbReference type="KEGG" id="loi:92361312"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047777">
        <property type="term" value="F:(S)-citramalyl-CoA lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106064">
        <property type="term" value="P:regulation of cobalamin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040186">
        <property type="entry name" value="Citramalyl-CoA_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11105:SF0">
        <property type="entry name" value="CITRAMALYL-COA LYASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11105">
        <property type="entry name" value="CITRATE LYASE SUBUNIT BETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH/HpaI aldolase/citrate lyase" evidence="3">
        <location>
            <begin position="151"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="HpcH/HpaI aldolase/citrate lyase" evidence="3">
        <location>
            <begin position="230"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="105"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="486"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="499"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="517"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5478039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="529" mass="57458" checksum="5B5D2A677C3AF776" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KJZ9</accession>
    <name>A0A836KJZ9_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_04316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062240.1">
        <property type="nucleotide sequence ID" value="XM_067206303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KJZ9"/>
    <dbReference type="SMR" id="A0A836KJZ9"/>
    <dbReference type="GeneID" id="92360237"/>
    <dbReference type="KEGG" id="loi:92360237"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032364540" evidence="1">
        <location>
            <begin position="24"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5475732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="183" mass="20278" checksum="D244D8C19D920000" modified="2021-09-29" version="1">MIKSCRFYLWHIACQLIIPHSAAMSQGNDDWGDMVLPGVYMIQRRSGTGTTGGTVQPDKTVNLELVHLEIDETEKYIELLQKSNREIAAYLKEKQESRSAQEEGRGSGSMVALSDGCVGEEGDDEAFREAIDENILVVARKKRELEHLRALIGAQRCGCLCTHAQDQDPQSTAALSDQARITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KK19</accession>
    <name>A0A836KK19_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cleavage and polyadenylation specificity factor subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cleavage and polyadenylation specificity factor 100 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_04358</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">LSCM4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062552.1">
        <property type="nucleotide sequence ID" value="XM_067206343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KK19"/>
    <dbReference type="GeneID" id="92360277"/>
    <dbReference type="KEGG" id="loi:92360277"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006398">
        <property type="term" value="P:mRNA 3'-end processing by stem-loop binding and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000102">
        <property type="entry name" value="Cleavage and polyadenylation specificity factor subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027075">
        <property type="entry name" value="CPSF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025069">
        <property type="entry name" value="Cpsf2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922:SF1">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13299">
        <property type="entry name" value="CPSF100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Beta-Casp" evidence="6">
        <location>
            <begin position="256"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="426"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="466"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5477141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="829" mass="90635" checksum="5371A1CA627D6A6D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KK51</accession>
    <name>A0A836KK51_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aldehyde dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_04464</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">LSCM4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062657.1">
        <property type="nucleotide sequence ID" value="XM_067206448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KK51"/>
    <dbReference type="SMR" id="A0A836KK51"/>
    <dbReference type="GeneID" id="92360382"/>
    <dbReference type="KEGG" id="loi:92360382"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07091">
        <property type="entry name" value="ALDH_F1-2_Ald2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000001">
        <property type="entry name" value="Aldehyde dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000001">
        <property type="entry name" value="Mitochondrial aldehyde dehydrogenase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="28"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5477246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="498" mass="54024" checksum="AA4C82C2836DEA71" modified="2021-09-29" version="1">MLRATRTRLEMAPKVTHIQDKLLINGKFVPATSGKMFEVVNPADESVIATVAEADKADVDIAVKAARQAFESFRTTDCHWRRDVMLRLADILEKNCKEMAALESLDNGKPYEAAKADVAFSVECFRFYAGLADKADGCVPPRSGHCLGIVKRQPIGVCGQIIPWNFPLLMAAFKLSPALAMGNTVVLKPAEQTPLSALRLGEMAMEAGYPAGVLNIVPGFGATAGAAIARHMDVDKVAFTGSTAVGREVMRMAAETNLKKVSLELGGKSALIVCEDADVEEAALVATTGVFLNAGQVCMASSRIYVHESVYDEFLARLRTRAEARRVGPGNNTENNMGPLVSKRQRERVLAYIEDGVKAGATVVTGGKRISGKGYFVQPTIFADVKEDMRICKEEIFGPVTCVMQFRDLDEVVRRANDSIYGLAAGICTRNMDTALRYSTYLNAGTVWVNTWNDFCVTMPFGGFKQSGIGRELGTDAIDLYTESKAIHFALKGPIVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KK57</accession>
    <name>A0A836KK57_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_03655</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061588.1">
        <property type="nucleotide sequence ID" value="XM_067205651.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836KK57"/>
    <dbReference type="GeneID" id="92359585"/>
    <dbReference type="KEGG" id="loi:92359585"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF341">
        <property type="entry name" value="NFX1-TYPE ZINC FINGER-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="2">
        <location>
            <begin position="1206"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="3">
        <location>
            <begin position="1293"/>
            <end position="1484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1078"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1540"/>
            <end position="1602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1578"/>
            <end position="1589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5473585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1602" mass="176553" checksum="CF0D1E113011EDD8" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KK65</accession>
    <name>A0A836KK65_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LSCM4_04509</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">LSCM4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062702.1">
        <property type="nucleotide sequence ID" value="XM_067206493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KK65"/>
    <dbReference type="SMR" id="A0A836KK65"/>
    <dbReference type="GeneID" id="92360427"/>
    <dbReference type="KEGG" id="loi:92360427"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000306">
        <property type="entry name" value="IKS protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001431">
        <property type="entry name" value="Protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF138">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE IKS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="450"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="219"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="405"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="758"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="851"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="408"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="784"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="851"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="881"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="483"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG5477291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="932" mass="99635" checksum="CF4ECF0A4C347105" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KKG7</accession>
    <name>A0A836KKG7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CYC2-like cyclin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5468998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059975.1">
        <property type="nucleotide sequence ID" value="XM_067204423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KKG7"/>
    <dbReference type="GeneID" id="92358357"/>
    <dbReference type="KEGG" id="loi:92358357"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000164">
        <property type="entry name" value="CYC2-like cyclin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF112">
        <property type="entry name" value="CYCLIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="587"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="919"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1015"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5468998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1052" mass="111061" checksum="B76785F30DD2CBEB" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KKS8</accession>
    <name>A0A836KKS8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Abnormal spindle-like microcephaly-associated protein ASH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_01906</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">LSCM4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000022">
        <property type="protein sequence ID" value="KAG5479314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063407.1">
        <property type="nucleotide sequence ID" value="XM_067203948.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92357882"/>
    <dbReference type="KEGG" id="loi:92357882"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056343">
        <property type="entry name" value="CFAP47_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053879">
        <property type="entry name" value="HYDIN_VesB_CFA65-like_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058952">
        <property type="entry name" value="Ig_CFAP47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45912">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45912:SF3">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24529">
        <property type="entry name" value="CFAP47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22544">
        <property type="entry name" value="HYDIN_VesB_CFA65-like_Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26579">
        <property type="entry name" value="Ig_CFAP47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HYDIN/VesB/CFA65-like Ig-like" evidence="7">
        <location>
            <begin position="392"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Cilia- and flagella-associated protein 47" evidence="8">
        <location>
            <begin position="1371"/>
            <end position="1573"/>
        </location>
    </feature>
    <feature type="domain" description="CFAP47-like immunoglobulin-like" evidence="9">
        <location>
            <begin position="2575"/>
            <end position="2682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="6"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1427"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1461"/>
            <end position="1472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF26579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5479314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2795" mass="301148" checksum="AD35135662631F80" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KKV1</accession>
    <name>A0A836KKV1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_05424</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5478026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062933.1">
        <property type="nucleotide sequence ID" value="XM_067207365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KKV1"/>
    <dbReference type="GeneID" id="92361299"/>
    <dbReference type="KEGG" id="loi:92361299"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01887">
        <property type="entry name" value="IF2_eIF5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053905">
        <property type="entry name" value="EF-G-like_DII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF6">
        <property type="entry name" value="INITIATION FACTOR IF-2, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22042">
        <property type="entry name" value="EF-G_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="179"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="463"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="626"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="834"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="463"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="475"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="834"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="875"/>
            <end position="885"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5478026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="885" mass="100018" checksum="129B2900F0AAB86D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KL62</accession>
    <name>A0A836KL62_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_03823</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061756.1">
        <property type="nucleotide sequence ID" value="XM_067205819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KL62"/>
    <dbReference type="GeneID" id="92359753"/>
    <dbReference type="KEGG" id="loi:92359753"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5474650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="261" mass="28416" checksum="4F991B864C4E00C3" modified="2021-09-29" version="1">MVSWTRRLHARWASPLWYEGEVVHFSSDAQTGLVRLVARLCSNAAATLSGAGAAAVRDEEFGRRCRAARVAQCVPFSSKQVFASATPLSADETQDKDALEATAACIFPCYISCGCPAVVHVSPGYHDSSPSEGEATSVSWPPPSLQIRRLYVHDPSGRKDNTRDTRRTSYYVRLPDACFQCWQEHNKVVGEFLDTVEKRPPSPLKERFMGLTSLDIEVLELLNLTETLGCAAGGCGSTSVDLTRKTCSDGAIGEVLPMPTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KNU5</accession>
    <name>A0A836KNU5_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_04599</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062791.1">
        <property type="nucleotide sequence ID" value="XM_067206582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KNU5"/>
    <dbReference type="SMR" id="A0A836KNU5"/>
    <dbReference type="GeneID" id="92360516"/>
    <dbReference type="KEGG" id="loi:92360516"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5477380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="129" mass="14168" checksum="C49186C138D196A9" modified="2021-09-29" version="1">MPPRRKPTPRSKSRSASQSSQKSSPRPSGRAPAKSPSLPPPDPVAVQRLVDEAIARARERRASNDVTAQRTNVSASSHEPVSERCATQLFSAGVSEKMTDIMRAFLVTCITVYFAWAGYAFYRELTTSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KNX9</accession>
    <name>A0A836KNX9_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_02086</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061159.1">
        <property type="nucleotide sequence ID" value="XM_067204122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KNX9"/>
    <dbReference type="GeneID" id="92358056"/>
    <dbReference type="KEGG" id="loi:92358056"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1280.10">
        <property type="entry name" value="HSP33 redox switch-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000397">
        <property type="entry name" value="Heat_shock_Hsp33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016154">
        <property type="entry name" value="Heat_shock_Hsp33_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016153">
        <property type="entry name" value="Heat_shock_Hsp33_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30111">
        <property type="entry name" value="33 KDA CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30111:SF1">
        <property type="entry name" value="33 KDA CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01430">
        <property type="entry name" value="HSP33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64397">
        <property type="entry name" value="Hsp33 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118352">
        <property type="entry name" value="HSP33 redox switch-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5472763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="492" mass="52969" checksum="AAC16A5B041DFB15" modified="2021-09-29" version="1">MRTSGVSHCAAGVVAKGGAAGAPCVSSSPPSSSSPAPVHRASHTFRTRDITLRVPSKDKLLRFAFCSTRHLLAETIRRHDLLRSTGAHLDFLELVGTQLTFSNLLASALEGEERVEARFTAEEATISTEALALGECRCCLRPEYNAQLAECGLPAFPLRVSRIQYRREKPFTSVVHADLNELLQPPPDVASSTAAAAATRTSEASHVPFSLYRPDMARRVPLEAWKRFFSYNSSLHAYNYLRRSEGSVPAVWMQSRIDAATLLNHGFLNTDGSAAGGAWQHGEACSGAAKEKKAQEVQRALLHAIPLSFGVVVTPLAAGDAMDRRVGQLNRVVMGAAAQLSASSEGGTPTIPVLQPLLDRCAQKYTTCQHILSLVSGDHDGAYQAAVAARQYNDDPARVAAVVDPIRRALGVQDFVIPLAATEAERTGLDFFCRCSKQNLMGSLVSASPCTLESLKESDNTVHCSFCGRQHTIADAEWQELVKARSGSALPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KNY4</accession>
    <name>A0A836KNY4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ankyrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_07113</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000018">
        <property type="protein sequence ID" value="KAG5481401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064080.1">
        <property type="nucleotide sequence ID" value="XM_067209017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KNY4"/>
    <dbReference type="SMR" id="A0A836KNY4"/>
    <dbReference type="GeneID" id="92362951"/>
    <dbReference type="KEGG" id="loi:92362951"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF9">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="194"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="227"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="272"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="138"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="154"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5481401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="33962" checksum="ED5B446305E8B0F9" modified="2021-09-29" version="1">MHLSELCRDSNIDAIIACLRQVAPLEPAPAPPSSEGAVDDDATAAAEHSSLHGLWSYQDNDGRTAFHWAIALKNFDLARKLMQPPYISPVLTEDEERSTPFATACSVGAPLDLLREILNRSVAEFAAYVKQRGAQLHAASEGQSSGSVVPTEPGQERNDGKPRKFLSDMLGVPQPADTTPASISTVLVGAEDAMGQTPLLLAVGRGHLGIVRFLLERGADLAHQNRRGQSPLHRAVNRGNMELVELLVSTSEKSNATNMAAHRAWMDLRDKHGDSALFYASMDNNEEIGRYLLRHGANRELRNADGKAFWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KRM2</accession>
    <name>A0A836KRM2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Calcium uniporter protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_07892</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">LSCM4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCU (TC 1.A.77) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000013">
        <property type="protein sequence ID" value="KAG5484326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064819.1">
        <property type="nucleotide sequence ID" value="XM_067209769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KRM2"/>
    <dbReference type="GeneID" id="92363703"/>
    <dbReference type="KEGG" id="loi:92363703"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990246">
        <property type="term" value="C:uniplex complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015292">
        <property type="term" value="F:uniporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036444">
        <property type="term" value="P:calcium import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051560">
        <property type="term" value="P:mitochondrial calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006769">
        <property type="entry name" value="MCU_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039055">
        <property type="entry name" value="MCU_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13462:SF46">
        <property type="entry name" value="CALCIUM UNIPORTER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13462">
        <property type="entry name" value="CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04678">
        <property type="entry name" value="MCU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium uniporter protein C-terminal" evidence="11">
        <location>
            <begin position="180"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5484326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="321" mass="35074" checksum="AE5AB3ACB9EDDB9A" modified="2021-09-29" version="1">MMRLTCCGAAAHCTRRHLLFRLPTTPSALRSHSTAAADAAAKAKLTSPGAPLNHVFKLVSKSDAASPSFVSRSVVVVHTSYAALPAAEGAHNFSRRLDAEAGEGSIATVHPSAAPSYTVTDVAAFEQLISEAVRLYPATLEAAATASAVPAPSPSPVPATPARQASARRAPTALISDHTVRELQILLAEAERALAPSTARKEKIDGFVYGVYLPLLKYGAFALLAVHFVVYFRWIFFVFDWNLAEPTTYFLSYTGVFCSLVYHYYRCGEDEFTWKNIFEHLASRKAEKTYAKEKLDVVDMAQLQRRIALIKQELAHMSLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KS49</accession>
    <name>A0A836KS49_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
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            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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</entry>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="protein sequence ID" value="KAG5480890.1"/>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="235" mass="25787" checksum="CDA3BC1443CF972A" modified="2021-09-29" version="1">MAAAADAGGSVEGELRQAKDKLKTLSTLAEQAERGAMIDYDLAQTLIHEVADRVRPLAQGKIHSFAGSTVVSSSDATLHARAGAGSSQNVTPLQRRRAEQVLSEVKLLETTLHRYAKKAQQHATYVSNMQSLFGGGAGVHRQNYEAMDHLEREKKSLQYARQRIQAMESESREVLAALQDQGRRLGGVGGKLGDLLETLGVSNTTILQIVRRNEADAWLVYGGIALLLFFLWYLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="scientific">Leishmania orientalis</name>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000009">
        <property type="protein sequence ID" value="KAG5486021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_067208641.1"/>
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        <location>
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            <end position="35"/>
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            <begin position="58"/>
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        </location>
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        <location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1073"/>
            <end position="1084"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5486021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1192" mass="125742" checksum="6A56F104D8FDFB95" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836KUM4_9TRYP</name>
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        <recommendedName>
            <fullName evidence="8">Vesicle transport protein</fullName>
        </recommendedName>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">LSCM4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the SFT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000005">
        <property type="protein sequence ID" value="KAG5487641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_067209962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KUM4"/>
    <dbReference type="GeneID" id="92363896"/>
    <dbReference type="KEGG" id="loi:92363896"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011691">
        <property type="entry name" value="Vesicle_transpt_SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137:SF6">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5487641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="164" mass="17557" checksum="BA6542DC7190629A" modified="2021-09-29" version="1">MDRVTSIITVATNGGTLDAAAGTDSEESLCPSLNFKQRVQGCLGCAALGTLLLVLSWVTVLLADYVFFGILFTLGSLMCLGSTLFLAGPARQLKSMFSEGRWIASTVYIITMVLTILCAVLLHSALLTILACIVQFLALAWYILTYIPFARDIVKGALSRGLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KV43</accession>
    <name>A0A836KV43_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_08346</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000001">
        <property type="protein sequence ID" value="KAG5488269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066316.1">
        <property type="nucleotide sequence ID" value="XM_067210215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KV43"/>
    <dbReference type="SMR" id="A0A836KV43"/>
    <dbReference type="GeneID" id="92364149"/>
    <dbReference type="KEGG" id="loi:92364149"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF83">
        <property type="entry name" value="ACYL-COA SYNTHETASE LONG-CHAIN, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="111"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5488269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="696" mass="77385" checksum="084EFE25BA380AEF" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KV50</accession>
    <name>A0A836KV50_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Intraflagellar transport protein-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_01880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000022">
        <property type="protein sequence ID" value="KAG5479288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063381.1">
        <property type="nucleotide sequence ID" value="XM_067203922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KV50"/>
    <dbReference type="SMR" id="A0A836KV50"/>
    <dbReference type="GeneID" id="92357856"/>
    <dbReference type="KEGG" id="loi:92357856"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035735">
        <property type="term" value="P:intraciliary transport involved in cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029602">
        <property type="entry name" value="IFT74"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31432">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 74 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31432:SF0">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 74 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="11"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="93"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="289"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5479288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="596" mass="67413" checksum="70005655C42A703A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KXR6</accession>
    <name>A0A836KXR6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_06265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000007">
        <property type="protein sequence ID" value="KAG5486800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065594.1">
        <property type="nucleotide sequence ID" value="XM_067208189.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92362123"/>
    <dbReference type="KEGG" id="loi:92362123"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1000.11:FF:000018">
        <property type="entry name" value="Sec7_domain_containing_protein_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF388">
        <property type="entry name" value="GOLGI-SPECIFIC BREFELDIN A-RESISTANCE GUANINE NUCLEOTIDE EXCHANGE FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="2">
        <location>
            <begin position="744"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="660"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1785"/>
            <end position="1813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2121"/>
            <end position="2150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5486800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="2215" mass="236117" checksum="E7B946021481B7F4" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FZH9</accession>
    <name>A0A836FZH9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Phosphomannomutase</fullName>
            <ecNumber evidence="5 13">5.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LSCM4_00202</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>alpha-D-mannose 1-phosphate = D-mannose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11140"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="EC" id="5.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the eukaryotic PMM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.8" evidence="5 13"/>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058392.1">
        <property type="nucleotide sequence ID" value="XM_067202291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836FZH9"/>
    <dbReference type="SMR" id="A0A836FZH9"/>
    <dbReference type="GeneID" id="92356225"/>
    <dbReference type="KEGG" id="loi:92356225"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00424"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004615">
        <property type="term" value="F:phosphomannomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02585">
        <property type="entry name" value="HAD_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1240.20:FF:000001">
        <property type="entry name" value="Phosphomannomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005002">
        <property type="entry name" value="PMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043169">
        <property type="entry name" value="PMM_cap"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10466">
        <property type="entry name" value="PHOSPHOMANNOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10466:SF0">
        <property type="entry name" value="PHOSPHOMANNOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03332">
        <property type="entry name" value="PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00445">
        <property type="entry name" value="alpha-phosphomannomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01143">
        <property type="entry name" value="C2.B.3:_Phosphomannomutase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01140">
        <property type="entry name" value="C2.B:_Phosphomannomutase_and_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="10"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG5464761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="247" mass="28065" checksum="A7DF439EC8C1DCE2" modified="2021-09-29" version="1">MVSDVILLFDVDGTLTPPRKAETSDMKEMLSKARAAGFKLGVVGGSDFVKQKEQLGESILEDFDFVFSENGLQAFKDGKEFHRNSLLQALGNDKVMAFVKKCLRLIADMNIPVQRGTFVEFRNGMFNVSPIGRNCSQEERDAFELFDKQHRIREKMISDLKEAFPDYPLAYSIGGQISFDVFPKGWDKTYCLQFVENDFKSIHFFGDKTSEGGNDYEIFTDSRTIGHSVKTYKDTIAILEKLIEESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FZI8</accession>
    <name>A0A836FZI8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Streptococcal hemagglutinin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_00217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="protein sequence ID" value="KAG5478062.1"/>
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        <source>
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    </evidence>
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</entry>
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                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000023">
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        <source>
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        </source>
    </evidence>
    <sequence length="622" mass="69145" checksum="3101FDBDD1181BCC" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GAT8</accession>
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        <recommendedName>
            <fullName evidence="3">Centrosomal protein of 162 kDa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_04760</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
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            <taxon>Trypanosomatida</taxon>
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            <taxon>Leishmania</taxon>
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    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <location evidence="1">Microtubule organizing center</location>
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            <location evidence="1">Centriole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CEP162 family.</text>
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    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="P:cilium assembly"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038774">
        <property type="entry name" value="CEP162-like"/>
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        <property type="entry name" value="CENTROSOMAL PROTEIN OF 162 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34031:SF1">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 162 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="7 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="390"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="96"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="237"/>
            <end position="292"/>
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    </feature>
    <feature type="coiled-coil region" evidence="9">
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            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="390"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="408"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5478527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="616" mass="69357" checksum="88034A8F2554426A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GDZ9</accession>
    <name>A0A836GDZ9_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_03302</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060866.1">
        <property type="nucleotide sequence ID" value="XM_067205314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GDZ9"/>
    <dbReference type="GeneID" id="92359248"/>
    <dbReference type="KEGG" id="loi:92359248"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="165"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5471749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="266" mass="28275" checksum="C475FA7A69A6E1A1" modified="2021-09-29" version="1">MTDVAHEYAPLLGKTRIYGTAKISSHADCRLSQPGKETGDELKEEADAAIADGTSPLVGPTPSYLRAPSGTPCAPLPLSLALSTSSGRSSVRTSLSAADAYKTAATTAKLQNLQGPALPNACESSGRGINVNFVSTCSSAAGVSMSPTLPSSHHAGDGGEAVTTAKDLDAHLHTMRTELQRSQRELRATLESTERAKEEQVRVTQEISDMERYKSTLDGIIAFTLMELEDAASGVEEVEERLARESSAAWRKLEEMQANLRREAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GE91</accession>
    <name>A0A836GE91_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_06153</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000020">
        <property type="protein sequence ID" value="KAG5480387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067208078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GE91"/>
    <dbReference type="SMR" id="A0A836GE91"/>
    <dbReference type="GeneID" id="92362012"/>
    <dbReference type="KEGG" id="loi:92362012"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="219"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="77"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5480387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="353" mass="39784" checksum="B9BD4522AA9F5312" modified="2021-09-29" version="1">MGQSAPKPSPRAQRPARITPQQRRQQLEEREMQKPLASTEQVRRRLPTLKEQWQAKREANAAARETNAAERKRKKNALRDALQDQRRQAEYEGESVDDVDDGARRGRDGSDSDDDRLQRAQAEAMLTEAQANAQLASFQAYMRNYRDFEQDLDNVGDDLVSTFDRDAATTAARKVAKGSGMGLGDGDDDEAIANVSVHSSDYADEELMQGLDDLDEEIEREFQGRIDALQQQVAEHKQQSLVYLREHNDKAAALQELQKAKQIEAQIKQLLDEHETPLRVQIEEQQATIAELENIIATRKQQSLAALRGGDKPTALALLKEAKGFESQLEEAKATLAILEEQREKQLRSKGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GJ36</accession>
    <name>A0A836GJ36_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061765.1">
        <property type="nucleotide sequence ID" value="XM_067205828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GJ36"/>
    <dbReference type="SMR" id="A0A836GJ36"/>
    <dbReference type="GeneID" id="92359762"/>
    <dbReference type="KEGG" id="loi:92359762"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="103"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5474659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="308" mass="35387" checksum="7827B3347ACCC49A" modified="2021-09-29" version="1">MSRLLRSKAVGAAAVAPETKTIAQLQAEVKLRERAIEDRKLLFLGLCEQSGAPAALGRQDDRMAPSDDPVAEARRLISRNAFLRDELKAIDAMERQYANDPRVRDKRNEVRLVQMQIAQVEREVDTLQQVKRRRDKGLRAIGRTEERTRRMRGQQHEMNSELREEVRRLMEELRELEKTDMEVRARCARLQDQVKLSVTDTDVQQLRQELQQQSAEIEKLASKEALWRTHHASVREEDHRIVAKYRRECAKLTEEAERLQGLLRQKDLELRRSYHLLGRFASVPSLSVVDASGVGDVVGGSLPASEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GJ73</accession>
    <name>A0A836GJ73_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA polymerase kappa</fullName>
            <ecNumber evidence="1">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LSCM4_03894</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="1"/>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061825.1">
        <property type="nucleotide sequence ID" value="XM_067205888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GJ73"/>
    <dbReference type="SMR" id="A0A836GJ73"/>
    <dbReference type="GeneID" id="92359822"/>
    <dbReference type="KEGG" id="loi:92359822"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03586">
        <property type="entry name" value="PolY_Pol_IV_kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.100:FF:000004">
        <property type="entry name" value="DNA polymerase IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.810:FF:000004">
        <property type="entry name" value="DNA polymerase kappa, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000054">
        <property type="entry name" value="Putative DNA polymerase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.60:FF:000025">
        <property type="entry name" value="Putative DNA polymerase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050116">
        <property type="entry name" value="DNA_polymerase-Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022880">
        <property type="entry name" value="DNApol_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11076:SF33">
        <property type="entry name" value="DNA POLYMERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11076">
        <property type="entry name" value="DNA REPAIR POLYMERASE UMUC / TRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UmuC" evidence="13">
        <location>
            <begin position="202"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="82"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="590"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="617"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="639"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG5474719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="656" mass="72664" checksum="1D3646592BD9C17E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GJA0</accession>
    <name>A0A836GJA0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">lipoyl(octanoyl) transferase</fullName>
            <ecNumber evidence="3">2.3.1.181</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_00329</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LipB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.181" evidence="3"/>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058514.1">
        <property type="nucleotide sequence ID" value="XM_067202413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GJA0"/>
    <dbReference type="SMR" id="A0A836GJA0"/>
    <dbReference type="GeneID" id="92356347"/>
    <dbReference type="KEGG" id="loi:92356347"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00592"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033819">
        <property type="term" value="F:lipoyl(octanoyl) transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000172">
        <property type="entry name" value="Lipoate-protein ligase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000544">
        <property type="entry name" value="Octanoyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020605">
        <property type="entry name" value="Octanoyltransferase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00214">
        <property type="entry name" value="lipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10993:SF7">
        <property type="entry name" value="LIPOYLTRANSFERASE 2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10993">
        <property type="entry name" value="OCTANOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21948">
        <property type="entry name" value="LplA-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01313">
        <property type="entry name" value="LIPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="6">
        <location>
            <begin position="40"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5464883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="265" mass="29517" checksum="7A1A68836039345F" modified="2021-09-29" version="1">MKAFFIGKREYRRVLNLQEVIFNAKIARQASVRRGESTLPLRPDVAILVEHSAPVYTVGRRDTAEGLPPQCTVDVVKTRRGGGVTYHGPGQLTMYPIANIQLLWKECTAEKSRSPIEWFSWALEEAMIQTAAMYHIPAHRHKTGVWADSYKDIPAQKLGAIGLQLGSWVSMHGAGFNVANDLRFFDDIIMCEMPGRRATSLSNEMQHRGVAEPPPLVQATAPVLLRKFIESLHQPPGCAAPQLVDLSADEDWYEHIVNAVDAPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GLV1</accession>
    <name>A0A836GLV1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062407.1">
        <property type="nucleotide sequence ID" value="XM_067207104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GLV1"/>
    <dbReference type="GeneID" id="92361038"/>
    <dbReference type="KEGG" id="loi:92361038"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33987">
        <property type="entry name" value="CALCINEURIN-LIKE METALLO-PHOSPHOESTERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33987:SF1">
        <property type="entry name" value="CALCINEURIN-LIKE METALLO-PHOSPHOESTERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="616"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5476174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="654" mass="70863" checksum="2B5EABD9AB1202EE" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GN10</accession>
    <name>A0A836GN10_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Translin-associated factor X-interacting protein 1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_04106</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062032.1">
        <property type="nucleotide sequence ID" value="XM_067206095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GN10"/>
    <dbReference type="SMR" id="A0A836GN10"/>
    <dbReference type="GeneID" id="92360029"/>
    <dbReference type="KEGG" id="loi:92360029"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032755">
        <property type="entry name" value="TSNAXIP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16306">
        <property type="entry name" value="TRANSLIN-ASSOCIATED FACTOR X-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16306:SF0">
        <property type="entry name" value="TRANSLIN-ASSOCIATED FACTOR X-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15739">
        <property type="entry name" value="TSNAXIP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translin-associated factor X-interacting protein 1 N-terminal" evidence="4">
        <location>
            <begin position="123"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="171"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="294"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5475524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="737" mass="81544" checksum="F00E88FB8E084198" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GN20</accession>
    <name>A0A836GN20_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_04121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062047.1">
        <property type="nucleotide sequence ID" value="XM_067206110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GN20"/>
    <dbReference type="GeneID" id="92360044"/>
    <dbReference type="KEGG" id="loi:92360044"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5475539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="599" mass="64870" checksum="3015E2A1FCD89BC7" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GNV6</accession>
    <name>A0A836GNV6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Lanosterol 14-alpha-demethylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_06050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000011">
        <property type="protein sequence ID" value="KAG5485412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065149.1">
        <property type="nucleotide sequence ID" value="XM_067207975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GNV6"/>
    <dbReference type="SMR" id="A0A836GNV6"/>
    <dbReference type="GeneID" id="92361909"/>
    <dbReference type="KEGG" id="loi:92361909"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11042">
        <property type="entry name" value="CYP51-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000095">
        <property type="entry name" value="Lanosterol 14-alpha-demethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050529">
        <property type="entry name" value="CYP450_sterol_14alpha_dmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304:SF2">
        <property type="entry name" value="24-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5485412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="478" mass="54090" checksum="6DDDB4007AD8E3BC" modified="2021-09-29" version="1">MLGELLLLLVAGLALYGWYFCKSFNTTRPTDPPVVRCTTPFVGHIVQFGKNPLPFMLNAKKRYGGVFTMNICGSRITVVGDVHQHSKFFTPRNEILSPRDVYKFMVPVFGEGVAYGAPYPRMREQLNFLAEELTVAKFQNFAPSIQHEVRKFMRENWNKDEGEINILEDCSAMIINTACQCLFGEDLRKRLDARQFAQLLAKMESCLIPAAVFMPWILKLPLPQSYRCRDARAELQEILSDIIIAREKEEAQKDSNTSDLLAGLLGAVYRDGTRMSQHEVCGMIVAAMFAGQHTSTITTTWSLLHLMDPRNKKHLAKLHQEIDEFPAQLNYDNVMEEMPFAEKCARESIRRDPPLIMLMRKVLKPVQVGKYVVPAGDIIACSPLLSHQDEEAFPDPRVWNPERNMKIVDGAFCGFGAGVHKCIGEKFGLLQVKTVLATVLRDYDFELLGPLPEPNYHTMVVGPTASQCRVKYIRKKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GPZ2</accession>
    <name>A0A836GPZ2_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_01765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000022">
        <property type="protein sequence ID" value="KAG5479176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063269.1">
        <property type="nucleotide sequence ID" value="XM_067203810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GPZ2"/>
    <dbReference type="SMR" id="A0A836GPZ2"/>
    <dbReference type="GeneID" id="92357744"/>
    <dbReference type="KEGG" id="loi:92357744"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1230">
        <property type="entry name" value="Apolipoprotein A-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58113">
        <property type="entry name" value="Apolipoprotein A-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5479176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="257" mass="28250" checksum="4F4FCCC5B33679FA" modified="2021-09-29" version="1">MPRTRDTRHQTQEMADKIAGVASQVQVEMSSMAQDAQKALASAKQDASDAAQNGAQNAMNTVQSYVHEGQRIASEQKAHLQEAVKKVVNVAHEYVEDARKIADPYVESAKAKVDSAKASVENARHSAQNAVGNAKEQVTAVRTKVTEKTQPYVSNYQEFDVTKTAAFHVLTHLISTVLYMIWRVTLLIPSLQHMIDVIHKKEADVTVAQNCAAMVQKVPIVGPRTVEVVTVAVSNVSADLREQVSQYHAMTQRFKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GQ20</accession>
    <name>A0A836GQ20_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone-binding protein RBBP4-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_05306</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5477914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062821.1">
        <property type="nucleotide sequence ID" value="XM_067207253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GQ20"/>
    <dbReference type="SMR" id="A0A836GQ20"/>
    <dbReference type="GeneID" id="92361187"/>
    <dbReference type="KEGG" id="loi:92361187"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022052">
        <property type="entry name" value="Histone-bd_RBBP4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050459">
        <property type="entry name" value="WD_repeat_RBAP46/RBAP48/MSI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22850">
        <property type="entry name" value="WD40 REPEAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12265">
        <property type="entry name" value="CAF1C_H4-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Histone-binding protein RBBP4-like N-terminal" evidence="5">
        <location>
            <begin position="39"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="187"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5477914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="466" mass="51136" checksum="429853F877A03F53" modified="2021-09-29" version="1">MEPCADVVCTGEVPPPVGAVSPTCSTAAAEEVTPYQETERFCTWRKHARNLYQHLFHIDLVWESPVAQLMPFVATKSGLATHTILSAARTGGQEQSYIQLLSATVPQNTQALDGSDAAYSEATGEVGGYGMAPHACGLSIERRILHDGDVLAARYAPVNPLLIASSSSNGNLYVFDWSRVPLGRFPNEPPRPRAPLPPNELSSDATEEERAQYQKRMRALNVVATEQDRWDRRVGEGQHVLTLKGGNGASENLGWSTSADGVVASGSTGRVCVWRVANLSKDDSREVEPYEIFLFEDEEARVTHVDFSWSSPDNFVAASSTGAVFFNDVRTKHTTELFSIENAATSLALSPLDGNALLVGDAMGNVLFFDMRQSSKAVQVDLLHDGEVTTVEWCPHSRHLFSTGGHDGVVCICNHTRHKTLFKHWGHTDVIMDLGWNWQEDGAGQLVSTDSNAIMLWRPRDFFYCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GRS1</accession>
    <name>A0A836GRS1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TOG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_02095</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TOG/XMAP215 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061168.1">
        <property type="nucleotide sequence ID" value="XM_067204131.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92358065"/>
    <dbReference type="KEGG" id="loi:92358065"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061863">
        <property type="term" value="F:microtubule plus end polymerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030951">
        <property type="term" value="P:establishment or maintenance of microtubule cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046785">
        <property type="term" value="P:microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007051">
        <property type="term" value="P:spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000063">
        <property type="entry name" value="Putative cytoskeleton-associated protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045110">
        <property type="entry name" value="XMAP215"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048491">
        <property type="entry name" value="XMAP215_CLASP_TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12609">
        <property type="entry name" value="MICROTUBULE ASSOCIATED PROTEIN XMAP215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21041">
        <property type="entry name" value="XMAP215_CLASP_TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TOG" evidence="8">
        <location>
            <begin position="16"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="8">
        <location>
            <begin position="285"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="8">
        <location>
            <begin position="1015"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="6">
        <location>
            <begin position="1194"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="535"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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        </location>
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            <begin position="935"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1294"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1694"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1762"/>
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        </location>
    </feature>
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        <location>
            <begin position="1840"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="635"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1003"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1258"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1337"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1369"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1406"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1735"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1795"/>
            <end position="1814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5472772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1968" mass="212011" checksum="E941EE001FC53407" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GS55</accession>
    <name>A0A836GS55_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5477969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067207308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GS55"/>
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    <dbReference type="KEGG" id="loi:92361242"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5477969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="297" mass="31684" checksum="1D7F2C9BACFF90AE" modified="2021-09-29" version="1">MQCRSSQDALARISDEEEDDVPEDLNLTFVPAAKRSALAASRAVGHRGHCATPLKLTSSAESGSTASEPKPRTETVYEQERNAKVRQLLAEQQSASKGVVYSLDAFEAPLPNPCAMVGFPDITGPSYASASAAYERDGQRRGPSQYRGRSDPEGRGQSGAGERGGPRRYRMPNPNMSEEEQARYIRHRRNMAVIRNALREVDPDTLEYMQVTQAPDQLPLSRDRDSFSKPYFSTNRGRGGLGAGGGASMPSHRGRGGMRGRGGGGFSPYSADRGAGGPRGGGRGNGGNGGSAPFSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GUN2</accession>
    <name>A0A836GUN2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein uS2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_00537</name>
        <name evidence="9" type="ORF">LSCM4_00548</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">LSCM4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S). Interacts with ribosomal protein S21.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058716.1">
        <property type="nucleotide sequence ID" value="XM_067202615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GUN2"/>
    <dbReference type="SMR" id="A0A836GUN2"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000012">
        <property type="entry name" value="40S ribosomal protein SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ribosomal_uS2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005707">
        <property type="entry name" value="Ribosomal_uS2_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="uS2_euk_arch"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11489">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00963">
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5465085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5465096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="246" mass="27517" checksum="6F1162FA5BCF1F05" modified="2021-09-29" version="1">MSAVESGSKVLRMKESDAQKLLAMRCHIGTRNQSSAMKKYIYGRTPEGSNIIDMHMLWEKLILAARVIAAVENPKDVCVCSSRLYGTRAIYKFSQHVGTSFHGGRFIPGTFTNQIQKKFVQPRVLVVTDPRTDHQAIREASLVNIPVIALCDTDAPLEYVDIAIPCNNRGIKSIGMMYWLLAREVLRLRGTIVRSVPWEEKVDLFFYRDPNEAAEEKAAAAAAAPAAEAEEGFGWVERNDDNAWEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GVV4</accession>
    <name>A0A836GVV4_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_00570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058749.1">
        <property type="nucleotide sequence ID" value="XM_067202648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GVV4"/>
    <dbReference type="SMR" id="A0A836GVV4"/>
    <dbReference type="GeneID" id="92356582"/>
    <dbReference type="KEGG" id="loi:92356582"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="112"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="227"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="375"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="510"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="631"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5465118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="856" mass="96571" checksum="E36A946810B9F651" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GW46</accession>
    <name>A0A836GW46_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059056.1">
        <property type="nucleotide sequence ID" value="XM_067203365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GW46"/>
    <dbReference type="SMR" id="A0A836GW46"/>
    <dbReference type="GeneID" id="92357299"/>
    <dbReference type="KEGG" id="loi:92357299"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="410"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5466166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="508" mass="55660" checksum="FEC7DC8CA368C63C" modified="2021-09-29" version="1">MEKGYEDANGSGRSHHKPNAVRKFFSRNVSIRSMTSKTDNASSVAGCESSNSPGSAREPEELEDHMEGSNYDKTEICIACGFPRGSTVCCPVTRRHHGTDELVTSGRHNSNHLRVPSTTKSIFAKLRKQFPVSPARHHHQSRQAGGESGSSTARELHPLAPGVEDTASDGADGHSRGMDAPFMGGAGDSLGRGNGVGDFRNGTYAHQLSEIDVHEAGDKVEEAASQEEAGVQYYCYTDENGYTYWYTQELQDSVQQQDFANNAAAALTSAQATSVYYEPQAGQVGEEFSVPPGSYVCEYVDENGQTMYCIYTPEVYGAQDNTAEQLSQAADSNNGRTTFTSATAAARPRFVSVSARDVTTSPKRKTPAAIFASITQALKSRRSHRSRGHVDPASISLRDDMDTDPPAPMGTVTSETSTTVGNDAANPYDNEVEEFMELLDENEKKRFLKERKRLIKELTACEKKERDALAKQRHDGVEVLGREERAEIFVLRNDQRIIKTAQKRQGSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GWJ7</accession>
    <name>A0A836GWJ7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Glutamate--cysteine ligase</fullName>
            <ecNumber evidence="3 11">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Gamma-ECS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">Gamma-glutamylcysteine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_07166</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-cysteine + L-glutamate + ATP = gamma-L-glutamyl-L-cysteine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glutamate--cysteine ligase type 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="3 11"/>
    <dbReference type="EMBL" id="JAFHLR010000018">
        <property type="protein sequence ID" value="KAG5481454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064133.1">
        <property type="nucleotide sequence ID" value="XM_067209070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GWJ7"/>
    <dbReference type="SMR" id="A0A836GWJ7"/>
    <dbReference type="GeneID" id="92363004"/>
    <dbReference type="KEGG" id="loi:92363004"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.50:FF:000009">
        <property type="entry name" value="Glutamate--cysteine ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004308">
        <property type="entry name" value="GCS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164">
        <property type="entry name" value="GLUTAMATE CYSTEINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164:SF0">
        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03074">
        <property type="entry name" value="GCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="5 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5481454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="688" mass="77952" checksum="702BABB3679AEEDC" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GXC3</accession>
    <name>A0A836GXC3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP-dependent 6-phosphofructokinase</fullName>
            <shortName evidence="14">ATP-PFK</shortName>
            <shortName evidence="14">Phosphofructokinase</shortName>
            <ecNumber evidence="14">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">pfk</name>
        <name evidence="16" type="ORF">LSCM4_03695</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2 14">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 14">
            <text>beta-D-fructose 6-phosphate + ATP = beta-D-fructose 1,6-bisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="14">Allosterically activated by AMP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="14">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12 14">Glycosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Atypical ATP-dependent clade 'X' sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="14"/>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GXC3"/>
    <dbReference type="SMR" id="A0A836GXC3"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020015">
        <property type="term" value="C:glycosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.450:FF:000002">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01981">
        <property type="entry name" value="Phosphofructokinase_II_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050929">
        <property type="entry name" value="PFKA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012004">
        <property type="entry name" value="PyroP-dep_PFK_TP0108"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005301">
        <property type="entry name" value="PRK06830.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45770">
        <property type="entry name" value="ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="Phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 14" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="13 14" id="KW-0327">Glycosome</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 14" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphofructokinase" evidence="15">
        <location>
            <begin position="98"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Peroxisomal targeting signal" evidence="14">
        <location>
            <begin position="484"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="171"/>
            <end position="172"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="196"/>
            <end position="199"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="225"/>
            <end position="227"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062393.1">
        <property type="nucleotide sequence ID" value="XM_067207090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H234"/>
    <dbReference type="GeneID" id="92361024"/>
    <dbReference type="KEGG" id="loi:92361024"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="302"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="157"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5476160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="590" mass="63669" checksum="DA190E625B4C0E36" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H393</accession>
    <name>A0A836H393_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LSCM4_02566</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060145.1">
        <property type="nucleotide sequence ID" value="XM_067204593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H393"/>
    <dbReference type="SMR" id="A0A836H393"/>
    <dbReference type="GeneID" id="92358527"/>
    <dbReference type="KEGG" id="loi:92358527"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070013">
        <property type="term" value="C:intracellular organelle lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16927">
        <property type="entry name" value="HATPase_Hsp90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.790:FF:000004">
        <property type="entry name" value="Heat shock protein 75 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.80:FF:000004">
        <property type="entry name" value="Heat shock protein 75 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11260:FF:000004">
        <property type="entry name" value="Heat shock protein 75 mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000009">
        <property type="entry name" value="Molecular chaperone HtpG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003555">
        <property type="entry name" value="PRK05218.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0346">Stress response</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="61"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="220"/>
            <end position="221"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="243"/>
            <end position="248"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR002583-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG5469168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="758" mass="84753" checksum="95E1DC269532AD3F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H508</accession>
    <name>A0A836H508_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome biogenesis protein NSA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000009">
        <property type="protein sequence ID" value="KAG5485984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065315.1">
        <property type="nucleotide sequence ID" value="XM_067208604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H508"/>
    <dbReference type="SMR" id="A0A836H508"/>
    <dbReference type="GeneID" id="92362538"/>
    <dbReference type="KEGG" id="loi:92362538"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001569">
        <property type="entry name" value="WD repeat-containing protein 74-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037379">
        <property type="entry name" value="WDR74/Nsa1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16038">
        <property type="entry name" value="NOP SEVEN ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16038:SF4">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 74"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
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                <person name="Al-Salem W.S."/>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
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            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic sidechains and P3' is any C-terminal residue.</text>
            <dbReference type="EC" id="3.4.26.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase U48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.26.1" evidence="10"/>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062531.1">
        <property type="nucleotide sequence ID" value="XM_067207228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H780"/>
    <dbReference type="GeneID" id="92361162"/>
    <dbReference type="KEGG" id="loi:92361162"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039731">
        <property type="entry name" value="Rce1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1/LyrA-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13046:SF0">
        <property type="entry name" value="CAAX PRENYL PROTEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13046">
        <property type="entry name" value="PROTEASE U48 CAAX PRENYL PROTEASE RCE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="CAAX prenyl protease 2/Lysostaphin resistance protein A-like" evidence="11">
        <location>
            <begin position="120"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5476298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="285" mass="31288" checksum="C7BEE73A69448C2A" modified="2021-09-29" version="1">MDLLVCAGASAAFVGAFYVWPCERRFFSSGVKSLWVASRDPTVYVDRNSDEAIRRRTISFGVCTFVSTVYLAFGSAPPLPPQRQSTWWRPVIRSSVSTLLLFAGPLSESCCLGTFEAPGSALLVWRNYVICPIGEEIFYRGVLFSLLRRRSSVARISVSAFLFALSHTHHLVSMATDAYRTGGGADFERNDVDKSERESWRSAGRSMCGMLAFTTLFGLMSGYYYEHVCEGSIVAIAAAHALCNVIGPPDFTVLRSGRFSAREKVASAAAYVAGVAGWTWTLLVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H7F6</accession>
    <name>A0A836H7F6_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060907.1">
        <property type="nucleotide sequence ID" value="XM_067205355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H7F6"/>
    <dbReference type="SMR" id="A0A836H7F6"/>
    <dbReference type="GeneID" id="92359289"/>
    <dbReference type="KEGG" id="loi:92359289"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5471790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="222" mass="23025" checksum="1744F24EA63852D1" modified="2021-09-29" version="1">MQSKQIALTATLLFFGGIVWGFVAIGLYVYRTNVTATSAVARGSEAAVAGATREGSQNFATSLPEALPGPSSPLNARPALGNALIRDESLWNALQNDLVAVDVSGMGKSESTEAAVPALAEIEIPITESDSNVPPTPSLPKLKVRQSLHQGGFVIVECCQIGKAGSSAGELCNCATAAGSMEDSTSPCAMVAANHVQSPDTCFYVFRPSTAPYGESQYLNTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H842</accession>
    <name>A0A836H842_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Endoplasmic reticulum transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060940.1">
        <property type="nucleotide sequence ID" value="XM_067205388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H842"/>
    <dbReference type="GeneID" id="92359322"/>
    <dbReference type="KEGG" id="loi:92359322"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5471823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="146" mass="16509" checksum="D1A6F478B42474BA" modified="2021-09-29" version="1">MVSFLMLEVNLVMVPVLALFVLYCVPVRVISTTAERITRLVEGYNLNGLTIMSAMAIASSFSFLFHFFEWHSKYDVKVRFTDISLQLQHDNKRLRLERNMYIQLVTCVLCLAVKKFAALQGRQASRHAVPAALSRATTSSPHTKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H8V7</accession>
    <name>A0A836H8V7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_08218</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000003">
        <property type="protein sequence ID" value="KAG5487994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066121.1">
        <property type="nucleotide sequence ID" value="XM_067210088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H8V7"/>
    <dbReference type="SMR" id="A0A836H8V7"/>
    <dbReference type="GeneID" id="92364022"/>
    <dbReference type="KEGG" id="loi:92364022"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000660">
        <property type="entry name" value="Mitogen-activated protein kinase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000850">
        <property type="entry name" value="Protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="15"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5487994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="379" mass="42525" checksum="19BA286666DCF3B2" modified="2021-09-29" version="1">MQESNTLIFDVPDAFQVESIIGQGAYGAVCKAVFCEDQIAVKKIPHYSRSEDTARRVLREVEILQKLQFCEQVVGCRLFFRPKSEEKDVYVAMDYIPSDLSSVIKNGAITLDENVVRYITCQLLLALRALHRCNVLHRDVSTRNILIHYNSQVFLCDFGLSRFFDPDEQLSFGVVTQWYRAPEIILDAVYSYPSDVWSVGVILGELLLRRHLFPGKSNDSANQLQLIFHLVGTPSKDVFDADRSFGRASQNAKNYALAYIERRPCASALVNLLSTAPVLHHSATAAAPPQAVQLAEQLLQFDPAKRPSADEALRHPWFDPCRAFIDEVVQHQDVEEIPLFTQTQNLSLEDLVKRIEEVVPVFSEDLLVEDDGGGAVSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HB75</accession>
    <name>A0A836HB75_9TRYP</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name type="scientific">Leishmania orientalis</name>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000002">
        <property type="protein sequence ID" value="KAG5488214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067210064.1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5488214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="199" mass="21979" checksum="41F0B1B00C424E7F" modified="2021-09-29" version="1">MPLKEISDTVYRDEEVRAVAAATDEGDSDDQSVEDYAVDYKLPPLTSDSRLADEVAAIVACMAKMNESVKVMCDTEAALPSASAAPWWSSALRMWDMKASAARLGYHARTALSWSHSSLEQLLLQAVITTRQWTRARSSFSRSTTDKGSRLDCAMASRPSRSCRRTSPIARGAYRRSWRCCSRSASGPLRRSKGTRESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HBB9</accession>
    <name>A0A836HBB9_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    <gene>
        <name evidence="2" type="ORF">LSCM4_07227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Trypanosomatida</taxon>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000015">
        <property type="protein sequence ID" value="KAG5483017.1"/>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5483017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="234" mass="26076" checksum="19398E0E3FE622F7" modified="2021-09-29" version="1">MPSKKKEFIYSIDPELFARSRAPASTIAMGMKSSHASSLCWADQVRREERIRELWGATYDRMNSQGETATEAVQRTRARDAARHEAYVHPDKNPELYSILYKRAPPPSLGKSSEATASSSSPQLRTVTIEPAGTSKDPVSPSGSPFARTARSTTHEYLQARCRHHTLQQRYPNGPATAAQAVGWLTSATEKASASSPEAPYCPYRQVRLRQIGAYRNPEDDEHALLFGYDYTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HDF0</accession>
    <name>A0A836HDF0_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_04305</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062229.1">
        <property type="nucleotide sequence ID" value="XM_067206292.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="loi:92360226"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
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    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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        <location>
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    </feature>
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            <begin position="503"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5475721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="761" mass="81155" checksum="A2536B20A6BA06E1" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HF07</accession>
    <name>A0A836HF07_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Polyprenol reductase</fullName>
        </recommendedName>
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        <name evidence="2" type="ORF">LSCM4_04227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062153.1">
        <property type="nucleotide sequence ID" value="XM_067206216.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="92360150"/>
    <dbReference type="KEGG" id="loi:92360150"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:3-oxo-5-alpha-steroid 4-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016095">
        <property type="term" value="P:polyprenol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Dfg10/SRD5A3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14624">
        <property type="entry name" value="DFG10 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14624:SF0">
        <property type="entry name" value="POLYPRENOL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5475645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="470" mass="51143" checksum="054D505690F0BB33" modified="2021-09-29" version="1">MAVECIEGMSVRVALAYWAASFAVLLLRLFCPEFAGLSSYGGRTAAATTTADVGDISRKREEVDSSAASVAILTRWCATPVHLLASSPLGTRRITRKQSFTAFYTIGLATSASLFWIRGTDNRGGAVSGPPSLAALSSPAPSPSLTCVPLLLFTLHCAVRLIETRLVQRFCERDTVTLFAAVAGSTFYVMAATSSAAPSHTHVPRGSHWLQRLVVVRCVFCAAAMAHLSLQAIQVTAHTILARLRQSPLHTVPSTKEVHVRDWEEGLWRRVQARLANSRLAQSEPPNALSAPPALYGAWRRYRYPYFSNVCFQVVLDPHYTCEVAMYAVNTALLFLCVLPDATQPAAEIAAGAERGTGSRLPTDGPRWWSIACASVPCLPLLASVGVTVFTAANLSITSAEHRRFWMVANAHRRLVAGTLRAVLDEEQPKALDNGGDRAPAEVINAAEYMLREAVVEEILPRWNMFPLVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HFG8</accession>
    <name>A0A836HFG8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphatase 2A Regulatory Subunit A helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_06144</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000020">
        <property type="protein sequence ID" value="KAG5480378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063709.1">
        <property type="nucleotide sequence ID" value="XM_067208069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HFG8"/>
    <dbReference type="SMR" id="A0A836HFG8"/>
    <dbReference type="GeneID" id="92362003"/>
    <dbReference type="KEGG" id="loi:92362003"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000616">
        <property type="entry name" value="Serine/threonine protein phosphatase 2A regulatory subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055231">
        <property type="entry name" value="2AA_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051023">
        <property type="entry name" value="PP2A_Regulatory_Subunit_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648:SF34">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22956">
        <property type="entry name" value="VPS15-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="2">
        <location>
            <begin position="219"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="2">
        <location>
            <begin position="257"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="2">
        <location>
            <begin position="374"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase 2A Regulatory Subunit A helical" evidence="3">
        <location>
            <begin position="378"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="2">
        <location>
            <begin position="413"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5480378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="599" mass="64427" checksum="766F405717D3A613" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HFU8</accession>
    <name>A0A836HFU8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Galactofuranosyltransferase lpg1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_05036</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062313.1">
        <property type="nucleotide sequence ID" value="XM_067207010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HFU8"/>
    <dbReference type="GeneID" id="92360944"/>
    <dbReference type="KEGG" id="loi:92360944"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43179:SF12">
        <property type="entry name" value="GALACTOFURANOSYLTRANSFERASE GLFT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43179">
        <property type="entry name" value="RHAMNOSYLTRANSFERASE WBBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="92"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5476080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="592" mass="65975" checksum="3C112ABC4A9D4270" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HI14</accession>
    <name>A0A836HI14_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_04438</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062631.1">
        <property type="nucleotide sequence ID" value="XM_067206422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HI14"/>
    <dbReference type="GeneID" id="92360356"/>
    <dbReference type="KEGG" id="loi:92360356"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="314"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5477220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="334" mass="34903" checksum="253E7F23A7506E8C" modified="2021-09-29" version="1">MANCKAFCWACLVAYSTIMLTITTAYLWMQLGRQRGFAEVREEMQHRHDGSANINGIAFAESGWAEYILVALFHTSHLICLALFLFGHQSRMKMVVGCALLLSCALVYIIFYGCVILQGRLEQLHQQRFLASSEAVAALQPKQGGSLPHEIEMHFADRATAGAVAAASPYNGEQDKVSRVSVEGVRGGLGKCGAASVDASDSLSYGSVVWSAFETLIDVLATIVSSSDGPAGSGEVDLHPDGALISSKVPFSGLFRLSLFVLNCAGFVLSICGVVLFDISSASEPAPISSAGPAASALSQLAAGLRGRAAAALSDSAAPASPPTVTAAEAKKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HK36</accession>
    <name>A0A836HK36_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_05508</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5478108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063015.1">
        <property type="nucleotide sequence ID" value="XM_067207447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HK36"/>
    <dbReference type="SMR" id="A0A836HK36"/>
    <dbReference type="GeneID" id="92361381"/>
    <dbReference type="KEGG" id="loi:92361381"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23791">
        <property type="entry name" value="UBCc_UBE2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000117">
        <property type="entry name" value="Putative ubiquitin-conjugating enzyme e2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="9"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5478108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="155" mass="17062" checksum="5B1FB990FBA6E3FD" modified="2021-09-29" version="1">MQGGGNSSGAAARLQKELIEVMMSDAEGISAYPEDDNLFRWIGSVKGVPNTPYEELEYNLLLVFPPNYPYEAPTVTFTTPCFHPNVDTRGAICLDILKEKWSAVYSVSSILLSIQNLLNNPNNESPLNNHAAQLWHDREQFTIVVRATHGGAPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HKF4</accession>
    <name>A0A836HKF4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome c oxidase copper chaperone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_04698</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COX17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000023">
        <property type="protein sequence ID" value="KAG5478465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063126.1">
        <property type="nucleotide sequence ID" value="XM_067206679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HKF4"/>
    <dbReference type="SMR" id="A0A836HKF4"/>
    <dbReference type="GeneID" id="92360613"/>
    <dbReference type="KEGG" id="loi:92360613"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1130">
        <property type="entry name" value="CytochromE C oxidase copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007745">
        <property type="entry name" value="Cyt_c_oxidase_Cu-chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16719">
        <property type="entry name" value="CYTOCHROME C OXIDASE COPPER CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16719:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE COPPER CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05051">
        <property type="entry name" value="COX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5478465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="113" mass="13369" checksum="3670814D4ECB38B8" modified="2021-09-29" version="1">MGIETWKTFPKILSEYPKHGVPLPCSDQHPRLPCPETRWARDFCLAQGGNCEYKIEAHFDCLAQHYPTEKVDELRKIFKPSTLDYPTSDTYIRYRHYYIGAPWMSKNNWEGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HL35</accession>
    <name>A0A836HL35_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_06813</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000009">
        <property type="protein sequence ID" value="KAG5486105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065436.1">
        <property type="nucleotide sequence ID" value="XM_067208725.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92362659"/>
    <dbReference type="KEGG" id="loi:92362659"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="716"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="219"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="893"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1135"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1234"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="912"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1144"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1234"/>
            <end position="1243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5486105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1542" mass="166425" checksum="FB6C1AECCA93E350" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HMV1</accession>
    <name>A0A836HMV1_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_07844</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000013">
        <property type="protein sequence ID" value="KAG5484278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064771.1">
        <property type="nucleotide sequence ID" value="XM_067209721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HMV1"/>
    <dbReference type="SMR" id="A0A836HMV1"/>
    <dbReference type="GeneID" id="92363655"/>
    <dbReference type="KEGG" id="loi:92363655"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="144"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="221"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="359" mass="39146" checksum="29982127257A1F8C" modified="2021-09-29" version="1">MSLVTQTLQGPRTTAAPATTKGNDPASATRASPVEAIAASMATFLADQEAAFEQLLGLCRSDMRQPPSVSHVRTVVAAAQLPPNVPLAPRSSTHFAGLPTGSATTEDKQRTRQVSRAGIVSELLKQDKASQQLLAVGRSAAREAEELQRATELEEEKLRLAQARNRLLRGRLATLTRERCKGLHHVARNTDENSADVVEAQGAPTSPITPSSDGYDYTNDIVEARRQLDQCTRELEETQARLHQLQQYHLSQLSGHFRPTMTASDALRTTENFLDTETNMAVRATVVDSLLEVNRALKPLSLQHDAPQSLGGALPCLDNVTTLWDRLAVQNFVVGRINRLLTCMCPNAPPLTLLKDTHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000006">
        <property type="protein sequence ID" value="KAG5487215.1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5487215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="260" mass="27213" checksum="C350C070EADDE217" modified="2021-09-29" version="1">MSAEAPCVMTCSWGSDDALQGRVRYTFVGEGGMEEAEAAMEESIASPPDSSLTFPAGSAAPWLTLHVGDTGAVALCFVTNARVLEIHDAVDDTSAPLLTQEAQVSNPATGLHGHFVCHGGSGVLFPPRRAYRLKLFARTPKASVIVASVCVVLFSRSISSSELGAERPSQSFGSQGTTQPLNPAIATLSAVIMEVSTALQRQLLVVESRIGGALNDVARRLTDLEGRVSRLETASDVVPKTEVVDSVTPTLPASLHADGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HN87</accession>
    <name>A0A836HN87_9TRYP</name>
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        <recommendedName>
            <fullName evidence="4">PUM-HD domain-containing protein</fullName>
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        <name evidence="5" type="ORF">LSCM4_05913</name>
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        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Trypanosomatida</taxon>
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            <taxon>Leishmania</taxon>
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    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067207843.1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="term" value="F:mRNA binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pumilio homolog 9"/>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
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        <property type="entry name" value="ARM-like"/>
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        <property type="entry name" value="ARM-type_fold"/>
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        <property type="entry name" value="PUM-HD"/>
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        <property type="entry name" value="Pumilio_RNA-bd"/>
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        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF190">
        <property type="entry name" value="RNA BINDING PROTEIN, PUTATIVE-RELATED"/>
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        <location>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="533"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="559"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5479905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="573" mass="64215" checksum="540465E184551B44" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836HNN8_9TRYP</name>
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        <recommendedName>
            <fullName evidence="3">Ferrochelatase-like protein</fullName>
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        <name evidence="1" type="ORF">LSCM4_05931</name>
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    <organism evidence="1 2">
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001015">
        <property type="entry name" value="Ferrochelatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00762">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5479923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="85" mass="9242" checksum="2581F39AE3C97B99" modified="2021-09-29" version="1">MDSLINDMKEAFSDAHRNKALLTKQAKVCFAIAPGFAVDCVETLSEIKLEAGEEFQKNGGHELIYVPCLNDTDAHVNVLTSVFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836HNP6_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_07057</name>
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    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Trypanosomatidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000018">
        <property type="protein sequence ID" value="KAG5481346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064025.1">
        <property type="nucleotide sequence ID" value="XM_067208962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HNP6"/>
    <dbReference type="GeneID" id="92362896"/>
    <dbReference type="KEGG" id="loi:92362896"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032389918" evidence="2">
        <location>
            <begin position="22"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="346"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5481346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="442" mass="49481" checksum="B588A31CB30EAB10" modified="2021-09-29" version="1">MQHYIFYVLFLLVSVAIGTDGLHVELTQSTLVGTEAELSPHAVRFSDTSLCFRTAAAVGESSNAIVSTHCTFDSGSTFEVMKNGSDMCLRGIVVDHQLFCPNEQVREAEDGVVEYAAVSFEAHDAAIHKKSNEKSLVFKGGKLVGALKQVSFNGNAIFMEREDIYIFVSTAVDEAGGKRVVVFRSEDGFAYQAISVIPNLEEAQQHYMIYEGGRKLSVLSSFNGSYYTRVSSGYAGKHWSAMKMLNVSTTPTSVMFSSGVQLQYACSNETSERAKWYVTDDKGRHSITKEAPQLPTVNDATARSPYLAFSMKAPEGDKKRLLVLQSESMGGAQTNVRASLFSVDDSAEEKYKADKIAKEKEELQKREVARLKAKHERLEREKLQRREQRRRELERKAKFITLDEPNVRSAKAFLEKDGEMIVVRRVRKDSVAFEKEVFFSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HS21</accession>
    <name>A0A836HS21_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UTP-monosaccharide-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="6">2.7.7.64</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_06964</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a monosaccharide 1-phosphate + UTP + H(+) = a UDP-monosaccharide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13205"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:140358"/>
            <dbReference type="ChEBI" id="CHEBI:140359"/>
            <dbReference type="EC" id="2.7.7.64"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the USP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.64" evidence="6"/>
    <dbReference type="EMBL" id="JAFHLR010000017">
        <property type="protein sequence ID" value="KAG5481885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064245.1">
        <property type="nucleotide sequence ID" value="XM_067208871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HS21"/>
    <dbReference type="SMR" id="A0A836HS21"/>
    <dbReference type="GeneID" id="92362805"/>
    <dbReference type="KEGG" id="loi:92362805"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051748">
        <property type="term" value="F:UTP-monosaccharide-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039741">
        <property type="entry name" value="UDP-sugar_pyrophosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952">
        <property type="entry name" value="UDP- GLUCOSE PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952:SF9">
        <property type="entry name" value="UDP-SUGAR PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5481885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="630" mass="68271" checksum="5A55B26754DA9FB5" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HUD7</accession>
    <name>A0A836HUD7_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_07481</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000004">
        <property type="protein sequence ID" value="KAG5487803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066000.1">
        <property type="nucleotide sequence ID" value="XM_067209368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HUD7"/>
    <dbReference type="GeneID" id="92363302"/>
    <dbReference type="KEGG" id="loi:92363302"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5487803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="320" mass="37097" checksum="40A03C37B702B426" modified="2021-09-29" version="1">MSAGAMRCIDRVRCWTASARTVWPSQHRCHPWLDTVCRRGACLGLALRSSYMPPAVAASSMSTSGALCTAYRHQATDQFHRYLHNPHVVQPDGVDGLPRVKGDQQQWLNTEQWYGYSATYLKRHMQYPATFEMNNPAIRARHDLLYECLGLVYELYGSLAEDLQELHDDPLHPQFHRRIARIERDRECIAAEIDKRYAKLHPTVKTVYDAFLVRRYYHLADWIRYVQRKRERLLNDLSPDVMEAMVKMRGIAEQHLRHLRSLEKALYEDPIMGLLEGDGSTSAIAQYTPGELAILRQKAAYFRKMRRFGANQLDADTHTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HXK7</accession>
    <name>A0A836HXK7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_07945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000013">
        <property type="protein sequence ID" value="KAG5484378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064871.1">
        <property type="nucleotide sequence ID" value="XM_067209821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HXK7"/>
    <dbReference type="SMR" id="A0A836HXK7"/>
    <dbReference type="GeneID" id="92363755"/>
    <dbReference type="KEGG" id="loi:92363755"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050228">
        <property type="entry name" value="Carboxylesterase_BioH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194">
        <property type="entry name" value="HYDROLASE ALPHA/BETA FOLD FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN LPX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="32"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5484378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="398" mass="43365" checksum="055FE836739D644C" modified="2021-09-29" version="1">MQRGASARPMKLAERVFSAKTVCATAASQLYVAHGLLGNAGNWTTALRRLVEHPSLKDKLRRAIAVDMRNHGSSAHSSDHSNAALASDLEALVLREQQELNRTFCDPASCTTRNAILIGHSMGGFSVIGSLLRRANEDRLLTPGADQCDDAGATSSYGYWPAEHRRECTAGMRAVNEEFGFASSQPISEVLFNSPGVPFPTTTNSGIASRIPPLGRVAGAIIVDVTPTMRLSEQRSGTDTVKQTLECMTQVRLDVIHSYEAAMAELMRVGMTDQEMRSFVATNIKLDPKDKSKPAQWRCNLPVLAGSYGSFQPSITSWFTSSVMTRGQASSPPRPCTLPVLFVFGGKSPYNEPHHRQHISRFFSNATQVEVADAGHFVHYEKTKEFADAVAPFIAPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HY61</accession>
    <name>A0A836HY61_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_07442</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000008">
        <property type="protein sequence ID" value="KAG5486506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065572.1">
        <property type="nucleotide sequence ID" value="XM_067209329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HY61"/>
    <dbReference type="SMR" id="A0A836HY61"/>
    <dbReference type="GeneID" id="92363263"/>
    <dbReference type="KEGG" id="loi:92363263"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF56">
        <property type="entry name" value="MAPKK KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="570"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="201"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5486506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="852" mass="94257" checksum="15515893B8EF8E66" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HZJ0</accession>
    <name>A0A836HZJ0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA pseudouridine(55) synthase</fullName>
            <ecNumber evidence="2">5.4.99.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_05989</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase Pus10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="2"/>
    <dbReference type="EMBL" id="JAFHLR010000011">
        <property type="protein sequence ID" value="KAG5485353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065090.1">
        <property type="nucleotide sequence ID" value="XM_067207916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HZJ0"/>
    <dbReference type="SMR" id="A0A836HZJ0"/>
    <dbReference type="GeneID" id="92361850"/>
    <dbReference type="KEGG" id="loi:92361850"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160148">
        <property type="term" value="F:tRNA pseudouridine(55) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3190:FF:000001">
        <property type="entry name" value="tRNA pseudouridine synthase Pus10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039894">
        <property type="entry name" value="Pus10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048741">
        <property type="entry name" value="Pus10-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21568">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE PUS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21568:SF0">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE PUS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21238">
        <property type="entry name" value="Pus10_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pus10-like C-terminal" evidence="6">
        <location>
            <begin position="515"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="271"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="276"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5485353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="720" mass="79016" checksum="EA705A50717D4636" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836I049</accession>
    <name>A0A836I049_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="8">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_06594</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="8">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="8"/>
    <dbReference type="EMBL" id="JAFHLR010000010">
        <property type="protein sequence ID" value="KAG5485638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065222.1">
        <property type="nucleotide sequence ID" value="XM_067208511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836I049"/>
    <dbReference type="SMR" id="A0A836I049"/>
    <dbReference type="GeneID" id="92362445"/>
    <dbReference type="KEGG" id="loi:92362445"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07834">
        <property type="entry name" value="STKc_MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000040">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000378">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="33"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5485638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="388" mass="43820" checksum="1CC39AEE2008DFDE" modified="2021-09-29" version="1">MHKSNQELSVPKIVGDFKVYNVSGSPFEVPAKYTLLKILGMGAYGIACSCLDSESGEKVSIKKCRDVFRDVEDGKRVLREIDMMRFFHHENLLNVVNILPPLKREYNSFEDVYVVTPLMDVDMNVVLRSRQVLEESHMQYFVYQILRGLKYLHSANVAHRDLKPANLVTNISCELKIIDFGLSRSVDVPYSELTDYVITRWYRPPELLLENTNYSTAVDIWSVGCIFAEMYNRKPVFPGRNTMDQLRMISQHIGKPPASIVEHREALEKLNELPEGSLNISKLVPGLAGNKEGMDFLAKMWTLDPSKRPTAADMLAHPYLSHLHDEEDEPACPCPFLWAHENNPMGVPELRRAFWADIVDYNPSLAQETPPVATPTGSGSKNGGGGHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836I0Y7</accession>
    <name>A0A836I0Y7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_08276</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000003">
        <property type="protein sequence ID" value="KAG5488051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066178.1">
        <property type="nucleotide sequence ID" value="XM_067210145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836I0Y7"/>
    <dbReference type="GeneID" id="92364079"/>
    <dbReference type="KEGG" id="loi:92364079"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17044">
        <property type="entry name" value="Ubl_TBCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044079">
        <property type="entry name" value="Ubl_TBCE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF275">
        <property type="entry name" value="TIR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14560">
        <property type="entry name" value="Ubiquitin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="476"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5488051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="550" mass="59374" checksum="2A376A9677EA38F6" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836I1Q5</accession>
    <name>A0A836I1Q5_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_07379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000008">
        <property type="protein sequence ID" value="KAG5486448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065514.1">
        <property type="nucleotide sequence ID" value="XM_067209271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836I1Q5"/>
    <dbReference type="SMR" id="A0A836I1Q5"/>
    <dbReference type="GeneID" id="92363205"/>
    <dbReference type="KEGG" id="loi:92363205"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="651"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="699"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="664"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="725"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="766"/>
            <end position="777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5486448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="929" mass="101764" checksum="2AD478DACD75FB2E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836I2M6</accession>
    <name>A0A836I2M6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_07713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000006">
        <property type="protein sequence ID" value="KAG5487225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065722.1">
        <property type="nucleotide sequence ID" value="XM_067209592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836I2M6"/>
    <dbReference type="SMR" id="A0A836I2M6"/>
    <dbReference type="GeneID" id="92363526"/>
    <dbReference type="KEGG" id="loi:92363526"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008832">
        <property type="term" value="F:dGTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006203">
        <property type="term" value="P:dGTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3210.10:FF:000034">
        <property type="entry name" value="HD domain containing protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050135">
        <property type="entry name" value="dGTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373">
        <property type="entry name" value="DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373:SF4">
        <property type="entry name" value="DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="58"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5487225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="454" mass="51235" checksum="2B8C80410FDC1599" modified="2021-09-29" version="1">MLRKHRTRELTILDRIYEHISLPPLIVAAIDTPAFQRLRSLHQLGASSFLYPGAVHTRFEHSIGVAHMARTLLLNFRHHQPDLGLSEVDIELGMLAGLFHDIGHGPFSHLFEDVISRRCGIEFNHEDMSEKIARRVLGDLIPQTHVDVVVGLMRGKALLGITYGEIISNKRNGIDVDRLDYFIRDSMCCFGKPTVDVRVNRLFNSARVVCEGGQWQLAFEQKLALSLREIFTLRAKLHKNVYQHQVTKAVGHMIGDAIHAAAPHFRVGGHTLVECAQDETLFLRLGDWILEAIEASEDPRLAEAHGILRRLRTRDIYRVVYASALDIAMRAQMAAVDWSVAILDHAHPSFPFNADDFIAEEVVINQGKGASDPLESVLFFNPKKPSQPLTRLKPAEDLKHGSPLFTPLQFEERTLMVFERRPTNGAVQRACERLSSDSAYAAFFTESLPFYNTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836I4D5</accession>
    <name>A0A836I4D5_9TRYP</name>
    <protein>
        <recommendedName>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <source>
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</entry>
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            <taxon>Leishmania</taxon>
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    </organism>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
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            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097157">
        <property type="term" value="F:pre-mRNA intronic binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000002">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.40:FF:000002">
        <property type="entry name" value="U5 snRNA-associated splicing factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.230:FF:000002">
        <property type="entry name" value="U5 snRNA-associated splicing factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.40:FF:000002">
        <property type="entry name" value="U5 snRNA-associated splicing factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.40">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012591">
        <property type="entry name" value="PRO8NT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012592">
        <property type="entry name" value="PROCN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012984">
        <property type="entry name" value="PROCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027652">
        <property type="entry name" value="PRP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021983">
        <property type="entry name" value="PRP8_domainIV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043173">
        <property type="entry name" value="Prp8_domainIV_fingers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043172">
        <property type="entry name" value="Prp8_domainIV_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019581">
        <property type="entry name" value="Prp8_U5-snRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042516">
        <property type="entry name" value="Prp8_U5-snRNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019580">
        <property type="entry name" value="Prp8_U6-snRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019582">
        <property type="entry name" value="RRM_spliceosomal_PrP8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140:SF0">
        <property type="entry name" value="PRE-MRNA-PROCESSING-SPLICING FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08082">
        <property type="entry name" value="PRO8NT"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF08083">
        <property type="entry name" value="PROCN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08084">
        <property type="entry name" value="PROCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12134">
        <property type="entry name" value="PRP8_domainIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10598">
        <property type="entry name" value="RRM_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10597">
        <property type="entry name" value="U5_2-snRNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="U6-snRNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="JAB1/MPN/MOV34 metalloenzyme" evidence="8">
        <location>
            <begin position="2178"/>
            <end position="2314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5466446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="2428" mass="277835" checksum="4BAB9F6C15C21943" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KAK3</accession>
    <name>A0A836KAK3_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_01627</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059366.1">
        <property type="nucleotide sequence ID" value="XM_067203675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KAK3"/>
    <dbReference type="GeneID" id="92357609"/>
    <dbReference type="KEGG" id="loi:92357609"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5466476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="289" mass="31358" checksum="6590184153EF6BDA" modified="2021-09-29" version="1">MRPCIMMECGAQRQTHDMLRHTVERLWHPFTLGHRGADLKTYRLREHLAGLCCPGSMFTCQVNGHLGGMRVLEDFFVTLLSGFDIIHASVEGSRGMSLSKPADMCNYTGYYVLAHTRPFLGWEPSPTSLRGVAPNSALAATSTHSSAEYGFNGAAPETASRSAFLLRDVDGDDGTDATVTLSGEANMETVQSNAVSSVYTLAVPFTTHVEGLVGQSCLSHLVLRTPVMELLRTRHECPDAVQKCLDSPEALRMFATLRRAGVKPELITAKTLLSATQSNAAWMSALGIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KAL6</accession>
    <name>A0A836KAL6_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059411.1">
        <property type="nucleotide sequence ID" value="XM_067203720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KAL6"/>
    <dbReference type="SMR" id="A0A836KAL6"/>
    <dbReference type="GeneID" id="92357654"/>
    <dbReference type="KEGG" id="loi:92357654"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019399">
        <property type="entry name" value="Parkin_co-regulated_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21207:SF6">
        <property type="entry name" value="PACRGB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21207">
        <property type="entry name" value="PARKIN COREGULATED GENE PROTEIN PARK2 COREGULATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10274">
        <property type="entry name" value="ParcG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5466521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="313" mass="34578" checksum="F95FD096EDCE872E" modified="2021-09-29" version="1">MPLKTFSQSEREKLRKDRDVLPPLSDGPLGPFPKGWNPPGRDAAKVTVSTSVNVAMAKNKASIGRVAAVAAPKAAQADILIGHTGTGGMTVSTFKGTGGANTSLSNGRFGDPAGPGEAGAYSKQRMPPTDFRHHYERSDLPLSIQHGAKRSLQWKVDVPKLDYHHYLPIFFDGLRELEEPFSFVAYQGSMDLLESGGAKILPTVPQLIMPLKIALNTRHPDVLRKVFHVIQKLVVSGDHIGEALVPYYRQLLPVFNLFKNRTRSMGDRMDYGQRKSHDISGLINDTLYLLERYGGPDAYINIKYMVPTYESCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KAQ9</accession>
    <name>A0A836KAQ9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_00747</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG5465292.1"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    </evidence>
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    </evidence>
    <sequence length="400" mass="46363" checksum="DA170683CC54A29A" modified="2021-09-29" version="1">MVFALTPPYAYRSSLPKCVLRIDGNWYDCTSWRNSHPGGAQMCDEFHGKDATDAFYSLHSKEAIQRLKRMKALPLKEGDEPRDQVSQNFEKLVQQLRSDGWFERRWAIDFSRNIIPVIALCVVGTYLSYSRPFLATILIGLGMQQGGWLAHDFTHARGKFARLLAKTLGGIINAFSVEWWSNKHNSHHVFVNRKGMDADIHNEPLLFLWAPDVSEDARGRRYQYMFYLAAYSLLFVSWRMQSLRFALGMGNRLELFLMALNYLWLVLLPWKVALGGVLLGGFCVAVVVTANHQTEEMIEHDEPYNYIVDQHRATRGVHCSDPFFEWFFGGMQYQLEHHLLPMVPRYRYPEARRILRKFSEENGLPFHVEGVCRIIKRNFDVLYRVSCLPAVDSAEVKKQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KBD7</accession>
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        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG5470224.1"/>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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        <location>
            <begin position="120"/>
            <end position="140"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="163"/>
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    <evidence type="ECO:0000256" key="1">
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        <source>
            <dbReference type="EMBL" id="KAG5470224.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="169" mass="17653" checksum="8CEF6A39F2567F85" modified="2021-09-29" version="1">MPVPSSSRNPRPLTGASVPSHDAAARQAAPMFCVNASIAGVCGALSGVVGKLAVESARVPLMVQRGGLYLGLDPAAMEMVQTVVPWLLRIFFFLMNAILTGSMWRFYLKALSQGPTPVCQILNTGTNFVASALAGLVLFAEEVTPMWGAGALLIVLGLALVVSDPQVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KGR5</accession>
    <name>A0A836KGR5_9TRYP</name>
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        <recommendedName>
            <fullName evidence="2">PSP1 C-terminal domain-containing protein</fullName>
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        <name evidence="3" type="ORF">LSCM4_03565</name>
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    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG5473496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061499.1">
        <property type="nucleotide sequence ID" value="XM_067205562.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="92359496"/>
    <dbReference type="KEGG" id="loi:92359496"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830">
        <property type="entry name" value="PROTEIN PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PSP1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
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    </feature>
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        <location>
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        <location>
            <begin position="742"/>
            <end position="821"/>
        </location>
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        <location>
            <begin position="590"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="633"/>
            <end position="646"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="767"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5473496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1139" mass="119530" checksum="E908441CD84981F4" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KHE1</accession>
    <name>A0A836KHE1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Arf3-interacting protein 1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061263.1">
        <property type="nucleotide sequence ID" value="XM_067204226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KHE1"/>
    <dbReference type="GeneID" id="92358160"/>
    <dbReference type="KEGG" id="loi:92358160"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052809">
        <property type="entry name" value="Actin_polarity_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012860">
        <property type="entry name" value="Afi1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28245">
        <property type="entry name" value="ARF3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28245:SF1">
        <property type="entry name" value="ARF3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07792">
        <property type="entry name" value="Afi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08616">
        <property type="entry name" value="SPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arf3-interacting protein 1 N-terminal" evidence="1">
        <location>
            <begin position="18"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5472867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="949" mass="99411" checksum="9FC2BBF204B59444" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KHT7</accession>
    <name>A0A836KHT7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_01245</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058993.1">
        <property type="nucleotide sequence ID" value="XM_067203302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KHT7"/>
    <dbReference type="GeneID" id="92357236"/>
    <dbReference type="KEGG" id="loi:92357236"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="503"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="3">
        <location>
            <begin position="46"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5466103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="532" mass="59591" checksum="8EBF9D2278A89DB4" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KIR5</accession>
    <name>A0A836KIR5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Adenylate kinase active site lid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_04598</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">LSCM4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the adenylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062790.1">
        <property type="nucleotide sequence ID" value="XM_067206581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KIR5"/>
    <dbReference type="SMR" id="A0A836KIR5"/>
    <dbReference type="GeneID" id="92360515"/>
    <dbReference type="KEGG" id="loi:92360515"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="5">
        <location>
            <begin position="133"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5477379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="234" mass="25633" checksum="72515A43D0B818DF" modified="2021-09-29" version="1">MSTKFLRLLFVGAPGVGKGTYSSRAAVSLRCHAVSSGDLLRKEVARGTPIGKQVKGLIETGVFVPDELITKMMVQHVASLSADKECPNGYILDGYPRNISQAASLWTSGDIKIDHVINLTQPRSVIMKKLSSRRSCPDCGFVYNLASIDEGGIRMDPLKPTVNGVCDKCGCTKPLITRKDDDIDVITKRQDEYSSVAMPLLRFYKEKGVLHDFPIRGGTEMCLPKLLELISSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KJ43</accession>
    <name>A0A836KJ43_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_05110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062384.1">
        <property type="nucleotide sequence ID" value="XM_067207081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KJ43"/>
    <dbReference type="GeneID" id="92361015"/>
    <dbReference type="KEGG" id="loi:92361015"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052423">
        <property type="entry name" value="EMIR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44094">
        <property type="entry name" value="DNAJ HEAT SHOCK N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44094:SF9">
        <property type="entry name" value="PROTEIN DNAJ, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="444"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="613"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="653"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="697"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5476151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="900" mass="99836" checksum="489A1908E2E68663" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KJY1</accession>
    <name>A0A836KJY1_9TRYP</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG5475672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <location>
            <begin position="998"/>
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        </location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5475672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1040" mass="112328" checksum="CC9FEC9E129A598E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KKE0</accession>
    <name>A0A836KKE0_9TRYP</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">LSCM4_05142</name>
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        <name type="scientific">Leishmania orientalis</name>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067207112.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="loi:92361046"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="11"/>
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        <location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5476182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="187" mass="20020" checksum="858CA6408F3729FF" modified="2021-09-29" version="1">MGSHTSRTLSCEGTDPAGAPASAAPSLCCSTASDVASKRGEQAELTRLRRSTQQHKNNGLRNAREHHLTRCKAAKDSQSGRALAAEQRSDLRQVRRDASELSTPSASTVAHQLAHRRSAGHMSIPLVHEQRSRPGVREQRPRQCWTDSPYTVQGDASARRVSSSYFALLAIDTSHGDGGGGGEPTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KL79</accession>
    <name>A0A836KL79_9TRYP</name>
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        <recommendedName>
            <fullName evidence="12">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="13" type="ORF">LSCM4_05710</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania orientalis</name>
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        <lineage>
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            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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        </lineage>
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    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RING-box family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067207642.1"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A836KL79"/>
    <dbReference type="GeneID" id="92361576"/>
    <dbReference type="KEGG" id="loi:92361576"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031463">
        <property type="term" value="C:Cul3-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="mRING-H2-C3H2C2D_RBX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000273">
        <property type="entry name" value="E3 ubiquitin-protein ligase RBX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051031">
        <property type="entry name" value="RING-box_E3_Ubiquitin_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024766">
        <property type="entry name" value="Znf_RING_H2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11210">
        <property type="entry name" value="RING BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12678">
        <property type="entry name" value="zf-rbx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="52"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG5479704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="106" mass="12208" checksum="2E3CA7D6217513AD" modified="2021-09-29" version="1">MQTKDEARTSSLVDGSKGNRFQLKKWNAVALWSWDIQVDTCAICRNHIMDLCIECQSNPSCSPKDCTVAWGACNHAFHMHCISRWLKTRNVCPLDNKEWVYLRYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KLZ9</accession>
    <name>A0A836KLZ9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_01878</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">LSCM4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="JAFHLR010000022">
        <property type="protein sequence ID" value="KAG5479286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063379.1">
        <property type="nucleotide sequence ID" value="XM_067203920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KLZ9"/>
    <dbReference type="GeneID" id="92357854"/>
    <dbReference type="KEGG" id="loi:92357854"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF203">
        <property type="entry name" value="PALMITOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="9">
        <location>
            <begin position="118"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="293"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5479286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="378" mass="42513" checksum="DB44D059DA675EA7" modified="2021-09-29" version="1">MIGCCKPQSEGGEWKDIYGDPVRPRRTGYEHPLDALQISAWAAIAVLALLHYTVQIPFLHGTFFIVVLVISSVLIASVVLTKVALELYPQQDPAVFRTDLPRLNQDELVPESAEPCTEPCVFCRRFVQVGCKHCSVCDKCVPGFDHHCRWLNSCVGARNYRLFATFMGVAWMGMAWVAALSLYMIQWMLRDVDSFKRRMSTRAYRSPTRAFPAVVFFNFVSLLIAVAGICSLGKLICFHVYLDITHQSTYEHIVKKRERKRALGEYRSQSGEPEANGCLACFELRKRRYFKRHGGNNTTQPEVNDDDDEYREADSSVPLHQRERTGTLGTGAGSEGGQRLTPHAKGRAFSLESRADGEVGQSAAYPAGSFFRTYEPVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KN33</accession>
    <name>A0A836KN33_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_01756</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000022">
        <property type="protein sequence ID" value="KAG5479167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063260.1">
        <property type="nucleotide sequence ID" value="XM_067203801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KN33"/>
    <dbReference type="GeneID" id="92357735"/>
    <dbReference type="KEGG" id="loi:92357735"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5479167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="243" mass="26706" checksum="5E1AA7A78283FB7F" modified="2021-09-29" version="1">MCAAMSIAQTSTPLVNTYVKPREVHNHIAHSRFTVSYASRAASFSTSVPTGSTHARDDMAMQKAVFETHKRAELMAFIGKHEKAGTISEADRRLSIIMLLNSAAKRDIEKGSQAGYPLPVVHFMRQTWAAFIQQAKDFCKADADKPFTMELSRNALENTSSLGVWFTGPQISLPLRRYTVQVVGADGAPHNITAVGLLSFAYSTYVMHLRSMSQQSALEGLARMQEQLGTNSLFLPQLLVAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KPW6</accession>
    <name>A0A836KPW6_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_04663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000023">
        <property type="protein sequence ID" value="KAG5478430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063091.1">
        <property type="nucleotide sequence ID" value="XM_067206644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KPW6"/>
    <dbReference type="GeneID" id="92360578"/>
    <dbReference type="KEGG" id="loi:92360578"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5478430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="212" mass="22126" checksum="89329ACAB257D203" modified="2021-09-29" version="1">MTASSVELEELKRRLIMHYEEEINAQLGVRASPAESDNSVQATSATPSYLYQRLLCLRAGRPYGVGVPTSASETVQLLAENQPPPEVMLTQRLHKAQDESVRLLAVHAAATAAASTGRESDQQDTAAATAYDATASDGVHEEVAIGPLTAQERTALLSKLAEAIASPPLAESTASGCAPAAGTHADDDVVADASEDQGGAANKKEEGAEEME</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KQ17</accession>
    <name>A0A836KQ17_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_04813</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000023">
        <property type="protein sequence ID" value="KAG5478580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063241.1">
        <property type="nucleotide sequence ID" value="XM_067206794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KQ17"/>
    <dbReference type="GeneID" id="92360728"/>
    <dbReference type="KEGG" id="loi:92360728"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5478580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="468" mass="50625" checksum="1692F5B73DB8BD72" modified="2021-09-29" version="1">MSAFPKVSGMRVCIVFDSRVGGDGRGYEELRQTVYAQCGQLLTLSRLHSSGDGAALFTTVHIVTHTRVVSYATSFHAQAADKSSESGAVDVMAGLRPLQVAQPDHSVGACGAAAFRNRMEIVMPCIQQTLADSQNRRQLILFCSSYVSHTEATQSLSGLRLDASPHQWLRCILVDWEAVSVTVGELTSNVRVYRCSRSARQLQAAMQDILCPFLMPDLRLSRRLGLKLGVQAVPVIATLWHYGVCLNEGNAIGSVARAGCAPPAAVFEASGTMCQCLTEASRRQTSVTAAAVAEGGDRGDWPLLHLRAILEADKVDESLLYGDTWVLALDTSAATASTLTSSSAPSRPYAASAVALWHAFCDAFFGDALVFIGEETGIEVCRHALQQHHHFVAYFMPDKTMRVREIVPPELRLVPLPAPPTREGLRERRAYGAEMQRLRQQLLSCCASASFSLDALLSSGWRGAASAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KQ26</accession>
    <name>A0A836KQ26_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Activator of Hsp90 ATPase AHSA1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_07023</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000018">
        <property type="protein sequence ID" value="KAG5481312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063991.1">
        <property type="nucleotide sequence ID" value="XM_067208928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KQ26"/>
    <dbReference type="SMR" id="A0A836KQ26"/>
    <dbReference type="GeneID" id="92362862"/>
    <dbReference type="KEGG" id="loi:92362862"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08892">
        <property type="entry name" value="SRPBCC_Aha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.15.10.20:FF:000006">
        <property type="entry name" value="Activator of Hsp90 ATPase, N-terminal/Activator of Hsp90 ATPase like protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.20">
        <property type="entry name" value="Activator of Hsp90 ATPase Aha1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036338">
        <property type="entry name" value="Aha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015310">
        <property type="entry name" value="AHSA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="ASHA1/2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13009">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 HSP90 CO-CHAPERONE AHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13009:SF22">
        <property type="entry name" value="LD43819P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09229">
        <property type="entry name" value="Aha1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01000">
        <property type="entry name" value="Aha1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103111">
        <property type="entry name" value="Activator of Hsp90 ATPase, Aha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Activator of Hsp90 ATPase AHSA1-like N-terminal" evidence="3">
        <location>
            <begin position="29"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="175"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="187"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5481312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="351" mass="38560" checksum="A89C5E225EB1A64B" modified="2021-09-29" version="1">MAKVGEGDPRWIVSERTDGANVNSWHWEERDLSQHAHNKLKSTFAEHAIPVPESMSESVEYLKIEDVSEISGDVTVAQRKGKMMCYFELKMTLRWVGKMAGAEQAVRGKMEVPEVDHEEFKNSYNILVTCQDNDAAAQQLEAVVQAAGRATVREEISAFFDALFAEYQIGKQLKSGAAMPPPPPAAPVSASTSPSTNASVDEKKPTAQPKPRSSDSEETSFSWRMRWGVPVAELYAALTDPSRASVYTRSTAAMDVKAGGQFSFLGGVISGYYVDVQPLSLIKQQWRLSSWPVGVHSSVVLQLVKEEPGVTTLEFAQSGIPAGQLQSVKEGWKANFFDAIKAVFGYSLEYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KQ47</accession>
    <name>A0A836KQ47_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_07099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000018">
        <property type="protein sequence ID" value="KAG5481387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064066.1">
        <property type="nucleotide sequence ID" value="XM_067209003.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836KQ47"/>
    <dbReference type="GeneID" id="92362937"/>
    <dbReference type="KEGG" id="loi:92362937"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="591"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="688"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="995"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1042"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1229"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1319"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1388"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1616"/>
            <end position="1666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1710"/>
            <end position="1737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="261"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="324"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="598"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="703"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1003"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1242"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1652"/>
            <end position="1665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1728"/>
            <end position="1737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5481387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1840" mass="194989" checksum="9957539E9442E536" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KQ57</accession>
    <name>A0A836KQ57_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">N-alpha-acetyltransferase 60</fullName>
            <ecNumber evidence="7">2.3.1.259</ecNumber>
            <ecNumber evidence="1">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LSCM4_07129</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-methionyl-[transmembrane protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-[transmembrane protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50604"/>
            <dbReference type="Rhea" id="RHEA-COMP:12745"/>
            <dbReference type="Rhea" id="RHEA-COMP:12746"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="ChEBI" id="CHEBI:133414"/>
            <dbReference type="EC" id="2.3.1.259"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the acetyltransferase family. NAA60 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.259" evidence="7"/>
    <dbReference type="EC" id="2.3.1.48" evidence="1"/>
    <dbReference type="EMBL" id="JAFHLR010000018">
        <property type="protein sequence ID" value="KAG5481417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064096.1">
        <property type="nucleotide sequence ID" value="XM_067209033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KQ57"/>
    <dbReference type="GeneID" id="92362967"/>
    <dbReference type="KEGG" id="loi:92362967"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120518">
        <property type="term" value="F:protein N-terminal-methionine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045141">
        <property type="entry name" value="NAA60-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14744">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14744:SF15">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="675"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="13">
        <location>
            <begin position="227"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="500"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="557"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="514"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG5481417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="702" mass="75644" checksum="0BE8315F5E1C6C9C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KQJ4</accession>
    <name>A0A836KQJ4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_06929</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000017">
        <property type="protein sequence ID" value="KAG5481852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064212.1">
        <property type="nucleotide sequence ID" value="XM_067208838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KQJ4"/>
    <dbReference type="SMR" id="A0A836KQJ4"/>
    <dbReference type="GeneID" id="92362772"/>
    <dbReference type="KEGG" id="loi:92362772"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008419">
        <property type="term" value="F:RNA lariat debranching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00844">
        <property type="entry name" value="MPP_Dbr1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007708">
        <property type="entry name" value="DBR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041816">
        <property type="entry name" value="Dbr1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849:SF0">
        <property type="entry name" value="LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849">
        <property type="entry name" value="RNA LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05011">
        <property type="entry name" value="DBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="569"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="482"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="482"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="538"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5481852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="629" mass="67185" checksum="DC965B1FC2559A2C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KQL3</accession>
    <name>A0A836KQL3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zinc finger ZPR1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_06991</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ZPR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000017">
        <property type="protein sequence ID" value="KAG5481912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064272.1">
        <property type="nucleotide sequence ID" value="XM_067208898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KQL3"/>
    <dbReference type="SMR" id="A0A836KQL3"/>
    <dbReference type="GeneID" id="92362832"/>
    <dbReference type="KEGG" id="loi:92362832"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.420:FF:000001">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.420:FF:000002">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1040:FF:000003">
        <property type="entry name" value="Zinc finger protein zpr1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1040">
        <property type="entry name" value="ZPR1, A/B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.420">
        <property type="entry name" value="ZPR1, zinc finger domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004457">
        <property type="entry name" value="Znf_ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040141">
        <property type="entry name" value="ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042451">
        <property type="entry name" value="ZPR1_A/B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056180">
        <property type="entry name" value="ZPR1_jr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042452">
        <property type="entry name" value="ZPR1_Znf1/2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00310">
        <property type="entry name" value="ZPR1_znf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10876">
        <property type="entry name" value="ZINC FINGER PROTEIN ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10876:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22794">
        <property type="entry name" value="jr-ZPR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03367">
        <property type="entry name" value="Zn_ribbon_ZPR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00709">
        <property type="entry name" value="Zpr1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger ZPR1-type" evidence="6">
        <location>
            <begin position="47"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger ZPR1-type" evidence="6">
        <location>
            <begin position="264"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="464"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5481912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="493" mass="55414" checksum="D81062B20646E50E" modified="2021-09-29" version="1">MSKEHNAELVTAEEPAAAHDDSDADLNEEENTNYIETDLGEVNVVESMCPKCRETGTTRLMITKIPHFKEIIVSSFECPHCSERNNEVTFGGTFGPKKVRYELEVKGRKDLDRQVVKSEFATVTIPELELEIPPESQKGNLNTVEGILEQTYNGLQLQQPLRKIQHPDVYEKIEAFCAKLESFRSGDVPFTLTLDDPAGNSYIEPIHDYYHPTLDPQLTKYEKERTDVDRQLLGVAIDYNTERTLEEEKDVEEGRFSDVTQIPCDCPACRKHGYLMMHECDIPYFKQTVIMAFKCEYCGYKSNEIKTGGEISAKGLRLTLHVKSEEDLKRDVLKSETAALIIPEVHLELAPGTLGGFFSSVEGTITQVRDQLKSLPQAAFAVGDSADDSSKTMLEFVKELDELLTLKKPFTFILDDPLGNVYIQNPRSHLPPPGDKDPNLESEEYIRSDEQDEELGILDMRRNVAQEDSEEAVDASDHGAENGTVAARQGAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KQV8</accession>
    <name>A0A836KQV8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Antigen LACK</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_04042</name>
        <name evidence="9" type="ORF">LSCM4_04043</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">LSCM4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061969.1">
        <property type="nucleotide sequence ID" value="XM_067206032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KQV8"/>
    <dbReference type="SMR" id="A0A836KQV8"/>
    <dbReference type="GeneID" id="92359966"/>
    <dbReference type="KEGG" id="loi:92359966"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045182">
        <property type="term" value="F:translation regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000018">
        <property type="entry name" value="Receptor for activated C kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045223">
        <property type="entry name" value="RACK1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19868">
        <property type="entry name" value="RECEPTOR FOR ACTIVATED PROTEIN KINASE C RACK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="61"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="103"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="146"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="190"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="284"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00082495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5474863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5474864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="312" mass="34437" checksum="5D3DBDE7B2AD43C4" modified="2021-09-29" version="1">MNYEGHLKGHRGWVTSLACPQQAGSYIKVVSTSRDGTAISWKANPDRHSVDSDYGLPDHRLEGHTGFVSCVSLAHATDYALTASWDRSIRMWDLRNGQSQHKFLKHTKDVLAVAFSPDDRLIVSAGRDNVIRVWNVAGECMHEFLRDGHEDWVSSICFSPSLEHPIVVSGSWDNTIKVWNVNEGRCERTLKGHSNYVSTVTVSPDGSLCASGGKDGAALLWDLSTGEQLFKINVESPINQIAFSPNRFWMCVATEKSLSVYDLESKAVIAELTPDGAKPSECISIAWSADGNTLYSGHKDNLIRVWSISDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KRU5</accession>
    <name>A0A836KRU5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="5">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_06161</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">LSCM4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="5">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="5"/>
    <dbReference type="EMBL" id="JAFHLR010000020">
        <property type="protein sequence ID" value="KAG5480395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063726.1">
        <property type="nucleotide sequence ID" value="XM_067208086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KRU5"/>
    <dbReference type="GeneID" id="92362020"/>
    <dbReference type="KEGG" id="loi:92362020"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003509">
        <property type="entry name" value="Putative ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="20"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="44"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="476"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="646"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="753"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="165"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="653"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5480395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="791" mass="84432" checksum="CADE511DA0251160" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KT04</accession>
    <name>A0A836KT04_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="8">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_04360</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">LSCM4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the peptidase C12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="8"/>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062554.1">
        <property type="nucleotide sequence ID" value="XM_067206345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KT04"/>
    <dbReference type="SMR" id="A0A836KT04"/>
    <dbReference type="GeneID" id="92360279"/>
    <dbReference type="KEGG" id="loi:92360279"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.532.10:FF:000006">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF17">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="9">
        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="7">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5477143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="233" mass="25463" checksum="F1F6FC12BB60CB44" modified="2021-09-29" version="1">MWFPLESNPTVMNRYITTLGVVEAKVQFVDVYGVSEDLLKLVPSPVHAVLLVYPICTATEERIAELQAVQREDVAALREAHAFFFTHQCVPNLCGTVAIAHALMNNRDKIGEIAPGSILDSEWAKAPSVPTDPKVIGQLLAEDKNLINAHAAAAQEGATANQNINSDINLHFVCFIRVGERCVELDGRKENPTLHGHCTDNASFLKAAAAAIHERMELNPHSYEFSITALVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KT99</accession>
    <name>A0A836KT99_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mannosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LSCM4_07607</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyltransferase 22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="JAFHLR010000012">
        <property type="protein sequence ID" value="KAG5484837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064949.1">
        <property type="nucleotide sequence ID" value="XM_067209489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KT99"/>
    <dbReference type="GeneID" id="92363423"/>
    <dbReference type="KEGG" id="loi:92363423"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF2">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE ALG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032383329" description="Mannosyltransferase" evidence="12">
        <location>
            <begin position="35"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="110"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="197"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="409"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="519"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="569"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG5484837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="790" mass="87455" checksum="39D82FD2F49E7268" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KTI3</accession>
    <name>A0A836KTI3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoglycerate mutase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_07339</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000008">
        <property type="protein sequence ID" value="KAG5486411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065477.1">
        <property type="nucleotide sequence ID" value="XM_067209234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KTI3"/>
    <dbReference type="SMR" id="A0A836KTI3"/>
    <dbReference type="GeneID" id="92363168"/>
    <dbReference type="KEGG" id="loi:92363168"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF44">
        <property type="entry name" value="PHOSPHATASE C1620.13-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000709">
        <property type="entry name" value="6PFK_2-Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="1">
        <location>
            <position position="9"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="8"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5486411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="185" mass="20277" checksum="9F98AF76E291A643" modified="2021-09-29" version="1">MAHIHICRHGQDMDNVHGILNGHRNEPLSELGRSQAATVADKIKARGIRYAAIYSSPLQRALETASVIGAAVGVPVHVRADLIERDFGVLSGKPYADIPKYAGDKVLKGDKVLFFLDVDGCETFDKCYERAQGVLADVNVRHAGEHVLLVCHGDIGKMLQAAHAQVEWQEGLRLPYFANTEVIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KTV4</accession>
    <name>A0A836KTV4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA-specific 2-thiouridylase MnmA-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000007">
        <property type="protein sequence ID" value="KAG5486801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065595.1">
        <property type="nucleotide sequence ID" value="XM_067208190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KTV4"/>
    <dbReference type="GeneID" id="92362124"/>
    <dbReference type="KEGG" id="loi:92362124"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000352">
        <property type="entry name" value="Putative tRNA-methyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000418">
        <property type="entry name" value="tRNA-methyl transferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046885">
        <property type="entry name" value="MnmA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11933:SF5">
        <property type="entry name" value="MITOCHONDRIAL TRNA-SPECIFIC 2-THIOURIDYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11933">
        <property type="entry name" value="TRNA 5-METHYLAMINOMETHYL-2-THIOURIDYLATE -METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03054">
        <property type="entry name" value="tRNA_Me_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20258">
        <property type="entry name" value="tRNA_Me_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-specific 2-thiouridylase MnmA-like C-terminal" evidence="1">
        <location>
            <begin position="499"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5486801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="602" mass="65252" checksum="F7E3BCCC2046AE47" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KU69</accession>
    <name>A0A836KU69_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_07829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000006">
        <property type="protein sequence ID" value="KAG5487339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065836.1">
        <property type="nucleotide sequence ID" value="XM_067209706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KU69"/>
    <dbReference type="GeneID" id="92363640"/>
    <dbReference type="KEGG" id="loi:92363640"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5487339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="394" mass="42436" checksum="77342B666074D433" modified="2021-09-29" version="1">MFISPCAGHDEEHAQMECTPPRGNGSTARILVPDSDTDDSLGLPISKVSPSSISTPAARAFSKRAARCAAALLSRHDAAASAVHQQKCMHQLGRLGGAYRSLAHGQPCTIWVRCYDLNARVIRETEAFFEGRMTDRLAHPHVTRKNGVLEAEPKAAFDVHSQRRSPESSLGCRAPLPSCTLSTQAARSMSNGSSAVDVEATLPQTGYSLSRGEQSALSLLCMEDTAGAKYMPSPLPTFAAHSTSDGGSWRMGLSESLCDRLPHRSCPAETHVTMPLWMYGEDAGSVHSSPSPAAHQCDSSSAAQRHFKRGRGDTNDSGPQHLKGRRGEFSTARELVFDDRSTSSSSQKATPREESAAARWGTSVPPSLSATVIALQNQRVQWDLLRQQSLFSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KUF5</accession>
    <name>A0A836KUF5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Trypanothione reductase</fullName>
            <ecNumber evidence="5">1.8.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">N(1),N(8)-bis(glutathionyl)spermidine reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">LSCM4_08039</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">LSCM4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Trypanothione is the parasite analog of glutathione; this enzyme is the equivalent of glutathione reductase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>trypanothione + NADP(+) = trypanothione disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16757"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58290"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58661"/>
            <dbReference type="EC" id="1.8.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="17">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.12" evidence="5"/>
    <dbReference type="EMBL" id="JAFHLR010000005">
        <property type="protein sequence ID" value="KAG5487594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065882.1">
        <property type="nucleotide sequence ID" value="XM_067209915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KUF5"/>
    <dbReference type="SMR" id="A0A836KUF5"/>
    <dbReference type="GeneID" id="92363849"/>
    <dbReference type="KEGG" id="loi:92363849"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015042">
        <property type="term" value="F:trypanothione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000051">
        <property type="entry name" value="Glutathione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000019">
        <property type="entry name" value="Trypanothione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000233">
        <property type="entry name" value="Trypanothione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046952">
        <property type="entry name" value="GSHR/TRXR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001864">
        <property type="entry name" value="Trypnth_redctse"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004776">
        <property type="entry name" value="PRK06116.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01423">
        <property type="entry name" value="trypano_reduc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737:SF2">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00470">
        <property type="entry name" value="TRYPANRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 17 19" id="KW-0274">FAD</keyword>
    <keyword evidence="8 19" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="17" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13 19" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="21">
        <location>
            <begin position="5"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="20">
        <location>
            <begin position="363"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="16">
        <location>
            <position position="461"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="160"/>
            <end position="162"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="195"/>
            <end position="202"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="18">
        <location>
            <begin position="52"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAG5487594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="491" mass="53265" checksum="B57F9614837ADE0A" modified="2021-09-29" version="1">MSRAYDLVVLGAGSGGLEAGWNAAALHKKKVAVVDLQKEHGPPFYAALGGTCVNVGCVPKKLMVTGAQYMDLIRESSGFGWEMKRDSIRPNWKTLIAAKNKVVSSINQSYQSMFADTEGLSFHMGFGVIEDAHTVVVRKCDDPSSDVLETLDTEYILIATGSWPTRLGIPGDELCITSNEAFYLEDVPKRTLCVGGGYISVEFAGIFNAYKPPGGHVDLCYRGEVILRGFDLELRKSLTKQLEANGIKVRTHVNPSKITKNNDGSKHVVFEDGSQADYDHVMLAIGRMPRSQSLQLEKAGVKTDKNGAVLVDAYSKTSVDNIYAIGDVTNRVMLTPVAINEGAAFVETVFSGKPRATDHSKVACAVFSIPPIGTCGMTEEQAAKEYDTVAVYESSFTPLMHNISGSTYKKFLIRIVTNESDGTVLGVHMLGDSAPEIIQSVGICMKMGAKISDFHSTIGVHPTSAEELCSMRTPAYFYEKGNRVEKLSSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KV51</accession>
    <name>A0A836KV51_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein uS4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">40S ribosomal protein S9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_00126</name>
        <name evidence="13" type="ORF">LSCM4_06328</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">LSCM4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFHLR010000007">
        <property type="protein sequence ID" value="KAG5486862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058317.1">
        <property type="nucleotide sequence ID" value="XM_067202216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KV51"/>
    <dbReference type="SMR" id="A0A836KV51"/>
    <dbReference type="GeneID" id="92356150"/>
    <dbReference type="KEGG" id="loi:92356150"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000023">
        <property type="entry name" value="40S ribosomal protein S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_uS4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005710">
        <property type="entry name" value="Ribosomal_uS4_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_uS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003139">
        <property type="entry name" value="PRK04051.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01018">
        <property type="entry name" value="uS4_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF5">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 8" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS4 N-terminal" evidence="11">
        <location>
            <begin position="5"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding S4" evidence="10">
        <location>
            <begin position="106"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5464686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG5486862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="189" mass="22028" checksum="52CF3599B130EA73" modified="2021-09-29" version="1">MRNYNNFNRVWKAPRRPFEKERLDREMKLCGQYGLRCKREIWRVNMTLSKMRRTARLLLTLPENHPRRLLEGSAIMRRCHEYGFLDEEKDKLDYVLSLTVPDILERRLQTIVFKAGLAKSVHHARVLIQQRHIAVAKQIVTIPSFMVRVSSERHIAFADASPFGSGRPGRVKRVRAKAAKRHAAGGDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KWH1</accession>
    <name>A0A836KWH1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Organic solute transporter Ostalpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_06058</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000011">
        <property type="protein sequence ID" value="KAG5485420.1"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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            <begin position="41"/>
            <end position="59"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="102"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="134"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="223"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="254"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="657"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="658"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5485420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="694" mass="76295" checksum="FF1B95F6429A91E8" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KY86</accession>
    <name>A0A836KY86_9TRYP</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">LSCM4_07830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Metakinetoplastina</taxon>
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            <taxon>Leishmania</taxon>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000006">
        <property type="protein sequence ID" value="KAG5487340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067209707.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="loi:92363641"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="554"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5487340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="581" mass="64211" checksum="F4B051BCB83F0E79" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FYE6</accession>
    <name>A0A836FYE6_9TRYP</name>
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        <recommendedName>
            <fullName evidence="2">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_03161</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Kinetoplastea</taxon>
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            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="GeneID" id="92359111"/>
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        <property type="component" value="Chromosome 31"/>
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        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C2_dom"/>
    </dbReference>
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        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
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        <property type="entry name" value="Ingression_C2_domain"/>
    </dbReference>
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        <property type="entry name" value="CONSERVED SERINE PROLINE-RICH PROTEIN (AFU_ORTHOLOGUE AFUA_2G01790)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="INGRESSION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
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    </feature>
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        <location>
            <begin position="236"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5471612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="264" mass="28957" checksum="B099DE40E191DF45" modified="2021-09-29" version="1">MGRLEIRVCSARNVANLQRVGKPDPYVKVKMRGKKRSHVSYRTRVIENCLNPVWNEVFKFQVADYDSTQVLFELWNDNVIVDDLLGTYNLSINGLTRGVVLDTWVILEGTKSSSSELRLRILAVDFGRDPAPGEKVTASIEQDSAPPPTSQAFRPPNKYSMPPQVISLPSYSTLPPGPPRPVVYGAPGAAMPQVQYGYVAPLPSQSYAYGAPPPPQQPQLHGYSYGTPPQRLPYIGGPPPPPIYGPVPSPPRPVQMAYGIPPDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G0S0</accession>
    <name>A0A836G0S0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UV excision repair protein RAD23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_02258</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RAD23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061328.1">
        <property type="nucleotide sequence ID" value="XM_067204291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G0S0"/>
    <dbReference type="GeneID" id="92358225"/>
    <dbReference type="KEGG" id="loi:92358225"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01805">
        <property type="entry name" value="Ubl_Rad23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.540:FF:000002">
        <property type="entry name" value="UV excision repair protein Rad23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000003">
        <property type="entry name" value="UV excision repair protein RAD23 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.540">
        <property type="entry name" value="XPC-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004806">
        <property type="entry name" value="Rad23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015360">
        <property type="entry name" value="XPC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036353">
        <property type="entry name" value="XPC-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10621">
        <property type="entry name" value="UV EXCISION REPAIR PROTEIN RAD23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10621:SF0">
        <property type="entry name" value="UV EXCISION REPAIR PROTEIN RAD23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09280">
        <property type="entry name" value="XPC-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01839">
        <property type="entry name" value="RAD23PROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101238">
        <property type="entry name" value="XPC-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="3">
        <location>
            <begin position="165"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="3">
        <location>
            <begin position="358"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="68"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5472932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="429" mass="44538" checksum="6D494DD24227150B" modified="2021-09-29" version="1">MKVILKTITGKQHEVDVEATSTILDVKKLLEDEYEPASLRLCFNGAVLEDSKMLADAGVKDNDSLVLAGRKRKIPKPPAQPSAEPPKTEATPENSAPSAASAPPSAMPAPVSTTASLAASAVPADPAAPALSAAHTAPTAPVVSANSAGPAIPAVPPASATSMYGVAPNLIDEVASMGFEDRNQIALALRAAFMNVERAVEYLFEGIPPHLVEELTHHTAAAAPAAAPGASNPSASSATAAAPVSATTASVAAPSTAKSEMRAALSRIPQFDEIRVLYNQNTDTLPVVMQQIAMRHPAVYEQIERDPETFLSIMGETGQPGTANTPSASAAPSTAQLAVGDAEEGSFMNQLQAGLELTAEDRTAVQQLVELGGGMWDEQSAVLVYLATQRNQEVAASVLFEHGGVPAELLAEIATQMADEEAEEYEDEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G1I2</accession>
    <name>A0A836G1I2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein eL8/eL30/eS12/Gadd45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_01203</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058956.1">
        <property type="nucleotide sequence ID" value="XM_067203265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G1I2"/>
    <dbReference type="SMR" id="A0A836G1I2"/>
    <dbReference type="GeneID" id="92357199"/>
    <dbReference type="KEGG" id="loi:92357199"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000001">
        <property type="entry name" value="60S ribosomal protein L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039109">
        <property type="entry name" value="Ribosomal_eL30-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022991">
        <property type="entry name" value="Ribosomal_eL30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002172">
        <property type="entry name" value="PRK01018.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11449">
        <property type="entry name" value="RIBOSOMAL PROTEIN L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00709">
        <property type="entry name" value="RIBOSOMAL_L30E_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00993">
        <property type="entry name" value="RIBOSOMAL_L30E_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="4">
        <location>
            <begin position="11"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5466066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="104" mass="11369" checksum="D296CC122E55E96D" modified="2021-09-29" version="1">MAKKTKSKVDTINAKLQLVMKSGKYVLGTQQALTTLRQGRSKLVVISNNCPPIRRAEVEYYCTLSKTPIHHYSGNNLDLGTACGKHFRTCVLSVTDVGDSDIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G202</accession>
    <name>A0A836G202_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Guanine nucleotide-binding protein subunit beta-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_01499</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059241.1">
        <property type="nucleotide sequence ID" value="XM_067203550.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92357484"/>
    <dbReference type="KEGG" id="loi:92357484"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051242">
        <property type="entry name" value="WD-EF-hand_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44324">
        <property type="entry name" value="WD40 REPEAT DOMAIN 95"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44324:SF4">
        <property type="entry name" value="WD40 REPEAT DOMAIN 95"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="493"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1430"/>
            <end position="1452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1437"/>
            <end position="1446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5466351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1761" mass="189135" checksum="355CA2B0F8C20560" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G2P7</accession>
    <name>A0A836G2P7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_00526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5468046.1"/>
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        <property type="nucleotide sequence ID" value="XM_067203198.1"/>
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            <dbReference type="EMBL" id="KAG5468046.1"/>
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    <sequence length="103" mass="12000" checksum="8C357F75E76F424D" modified="2021-09-29" version="1">MLRRVATKTTMAAAAPLLASARAYNMFVFKDPVRRPQLSPEERATVKINYAEWPEEFRDFDPDDPYKNSPEIIEGLSSWNLFLWGVECAFIYQFYEVVFPKSI</sequence>
</entry>
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    <accession>A0A836G624</accession>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Kwakye-Nuako G."/>
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                <person name="Al-Salem W.S."/>
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        <source>
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    <sequence length="341" mass="38831" checksum="11407252B2454942" modified="2021-09-29" version="1">MTSLDYAEKYRELGGLLRRYCDRKKWQTNSLQQQLNEEVSANVNLRKYIAFLEGRIQAGGESAMQSSRLLGDKKEGGNDALVERERCLHALAAQLESRLRMVHRRERKCAEFEAALKEREQQHLLGVNSFRKSKALFEAGLAASAKTVVSELQLSRDAGNYSSEPLDDFPSTNQLMQMQGCVFDHMTRCKEGILFFGRDECAARAFLLADEREERSSILSSFFREAAAHLRRHLGEQQVRDMQLHNAEDLLRLQEIDLVCRVRKETDLQQDSYAHVEMQRKVLEIQCKGVLRTVGDVLESLPDLDVEAVMTELENKIERVLQLQSANVSIGYPTHKAAGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G6X0</accession>
    <name>A0A836G6X0_9TRYP</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name type="scientific">Leishmania orientalis</name>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466554.1"/>
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    </dbReference>
    <dbReference type="RefSeq" id="XP_067059444.1">
        <property type="nucleotide sequence ID" value="XM_067203753.1"/>
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        <location>
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            <end position="201"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="138"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="465"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="520"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="652"/>
            <end position="662"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5466554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="662" mass="69280" checksum="0FA9FC6C11A6478D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="5">serine C-palmitoyltransferase</fullName>
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        <name evidence="13" type="ORF">LSCM4_01101</name>
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        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Leishmania</taxon>
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    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.50" evidence="5"/>
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    <dbReference type="KEGG" id="loi:92357100"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004758">
        <property type="term" value="F:serine C-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF2">
        <property type="entry name" value="SERINE PALMITOYLTRANSFERASE 1"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
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        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="12">
        <location>
            <begin position="110"/>
            <end position="479"/>
        </location>
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            <dbReference type="ARBA" id="ARBA00001933"/>
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            <dbReference type="ARBA" id="ARBA00004760"/>
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            <dbReference type="ARBA" id="ARBA00004991"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00013220"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG5468014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="488" mass="53985" checksum="F8C2813360CA904C" modified="2021-09-29" version="1">MSPVSEMLSQQLMEHPFHILLELFFAAALAYLLQQRFRRHRRAKSPHPMSLVPVEEQERRIAAFQSVPFRAECSVTSNVPVPEYHGMTEVVGREGSHITILRPGSSEVEDCLDLATYDFHSFSTLPEVVEVARATVNAYGVGSCGPRSFYGTIKPHLLVEQDLAKFLNTDDAVVYSFAHATVSTLISCFSSRGDYLVYDDGVNSSVIEGCRLSRSDIRSYKHCDMQNLEERLKEVAAADGHRQPHRRFVVTEGVFSSTGEICPLAKIVELCLKYKFRLVLEDSYGFGALGKSGRGTPEQFNIPTMDIDIYIGSLSTSMGAVGGFCAGSSSMIDHQRLAATAYVFSASLPPYITAAVSQSLAVLARDETFVANLQKHTKRMRKYLREAGFNKNKIKLVDSIDDVSPVILLAVEPSYVQNEGLEKVESRLQRVINALQKKKVAVVRNVFTKEELANTVSGLRIVAKSMATEAEVTAALKEIEAAVKVEFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G8D8</accession>
    <name>A0A836G8D8_9TRYP</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">LSCM4_02749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060322.1">
        <property type="nucleotide sequence ID" value="XM_067204770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G8D8"/>
    <dbReference type="GeneID" id="92358704"/>
    <dbReference type="KEGG" id="loi:92358704"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="687"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5470056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1150" mass="128235" checksum="B3F6EE233214F907" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G9G9</accession>
    <name>A0A836G9G9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Guanine nucleotide-binding protein subunit beta-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_02460</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060041.1">
        <property type="nucleotide sequence ID" value="XM_067204489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G9G9"/>
    <dbReference type="SMR" id="A0A836G9G9"/>
    <dbReference type="GeneID" id="92358423"/>
    <dbReference type="KEGG" id="loi:92358423"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045160">
        <property type="entry name" value="ATG16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19878">
        <property type="entry name" value="AUTOPHAGY PROTEIN 16-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19878:SF8">
        <property type="entry name" value="AUTOPHAGY-RELATED 16, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161270">
        <property type="entry name" value="PspA lactotransferrin-binding region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="291"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="324"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="356"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="525"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="54"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="182"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="526"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5469064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="589" mass="64650" checksum="5CFEBE6E13337DB4" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GBG2</accession>
    <name>A0A836GBG2_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
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    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12395">
        <property type="entry name" value="RRM2_RBM34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001656">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001177">
        <property type="entry name" value="Putative RNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034221">
        <property type="entry name" value="RBM34_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF119">
        <property type="entry name" value="NUCLEAR RNA-BINDING PROTEIN SART-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="157"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="266"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="344"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="360"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="420"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="441"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5466290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="451" mass="50567" checksum="2D11D54AEE506F39" modified="2021-09-29" version="1">MAESSTTLAAAAGAAPAFNFQPLQKSHVDLFATAPQVKKLTRREKDKMLRDLEVRRAQERATDLKDTVGKGKRALSKQCDRSAAVAEVVRTAATSSSSRDSAGAATEGQKKELFEIVFDTKEVEEELALQENRRNQRRAKKQVLRHALHTNEEEDARTVFVGNLPNTIHKRDVEKIFKSCGRITAVRIRCQALEELDEKHQNRGRAVRVLRGEIKKDPNYSSTAYVLFDSATSVASALDKNGLVFHNRHLVVTTMDVESRAYPPETSIFLGNVAYDTTEEDVWKFFQEHGIADVKRVRLVRDRETGDCKGFGYVEFMHASSVAPAIETRGDKLNGRELRIVHVNKSKEVKAATTSRREKRREGHAGGRGGAEERKRSRSVGDGNGGSRGSQSFFNLKRPRSESDLPPWAGLATNPRRKMPKDLRPIVEGKVEFKTRGPRAPVKRKMRNPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GJW2</accession>
    <name>A0A836GJW2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="5">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LSCM4_03704</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the poly(A) polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="5"/>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061637.1">
        <property type="nucleotide sequence ID" value="XM_067205700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GJW2"/>
    <dbReference type="SMR" id="A0A836GJW2"/>
    <dbReference type="GeneID" id="92359634"/>
    <dbReference type="KEGG" id="loi:92359634"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.10:FF:000032">
        <property type="entry name" value="PolyA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.590">
        <property type="entry name" value="Poly(A) polymerase predicted RNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011068">
        <property type="entry name" value="NuclTrfase_I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007012">
        <property type="entry name" value="PolA_pol_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048840">
        <property type="entry name" value="PolA_pol_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007010">
        <property type="entry name" value="PolA_pol_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682">
        <property type="entry name" value="POLY A POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682:SF10">
        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04928">
        <property type="entry name" value="PAP_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20750">
        <property type="entry name" value="PAP_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04926">
        <property type="entry name" value="PAP_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55003">
        <property type="entry name" value="PAP/Archaeal CCA-adding enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) polymerase nucleotidyltransferase" evidence="15">
        <location>
            <begin position="49"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase central" evidence="14">
        <location>
            <begin position="192"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase RNA-binding" evidence="13">
        <location>
            <begin position="345"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF20750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG5473634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="500" mass="55223" checksum="BB7DFB9A0753EA0E" modified="2021-09-29" version="1">MERTAEAAVIGEAFAHFNFSADAAASAALREAAVAFSMDNTDEVVILVRQLLGKLLQAEPSAAAAWTEVYVFGSSGLGAAITGSDIDLIALCSASVNTALFFQKFPRLAEGRLQNVVVVTSARVPLIKFSYNGVHVDLLFASVDMQTAPDTNELLRDDFLFLVSLPCRATVNGIRTILEIRRRLPLPLDAYACVLRAVKYWAAQRQVYGNLYTFPNGVCLAIMVARACQLCPVADSSVLFRFFFSLYVWWLLRDMRSDPVSIVPMDENAAMSRVPGMPPPWDAVWDAADLLPVLNPARPTVNAAHAVGRSGLQLFFKELLRAEQLCAAAPLSFSALWEPYNILDEYRFFVGVHIWCEHQSPAASEDTLNAWKGYVESKLRILVYALECVAEVRPFPHPVVDESPREVTRGWVPLHCRSRAFFFGIRNGNRDVARSDVEAAFSEFEFAVAEGATGTNPFEWDRAVMLGPRLSFFSIYDRLTADSPCQALYSACAEMMGSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GLN0</accession>
    <name>A0A836GLN0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_00874</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059592.1">
        <property type="nucleotide sequence ID" value="XM_067202942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GLN0"/>
    <dbReference type="SMR" id="A0A836GLN0"/>
    <dbReference type="GeneID" id="92356876"/>
    <dbReference type="KEGG" id="loi:92356876"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051493">
        <property type="term" value="P:regulation of cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        </location>
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            <dbReference type="SAM" id="Coils"/>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5467790.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="265" mass="29694" checksum="209236B40ACB86EB" modified="2021-09-29" version="1">MASVPFTEEDLHELYTWVDEIPLSRPKRNIARDFADGCSVAEILKFFFPKLVDLHNYVPAMSHAKKLDNWNTLNAKVLRKLYFEVPPEEVEDIVAAVPGAIERFLRALRMKVAQIKARREELLMMGDMQGYEKAHYADSSPSQPQNRETHYARDGLASAPAAHRGGGRPSSPGAPTGRAGSSQGSTSAGQEAPRRRPHSQRQPAALAVNEEAGSVDAVREKDYTIQELRETVAILSEKIVKLEELVRVKDEKLSQYRQKFGRMPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GLV7</accession>
    <name>A0A836GLV7_9TRYP</name>
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        <recommendedName>
            <fullName evidence="13">NADPH-cytochrome p450 reductase-like protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="11" type="ORF">LSCM4_00996</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
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        <lineage>
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    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
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        <property type="entry name" value="Flavoprotein-like_sf"/>
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    </dbReference>
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        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
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        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
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    </dbReference>
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        <source>
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        <source>
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            <dbReference type="ARBA" id="ARBA00023002"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5467910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="624" mass="68470" checksum="0A5A3E622B1E2B14" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GM29</accession>
    <name>A0A836GM29_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="72"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5476294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="72" mass="7775" checksum="FDBA2EA1E29E2C05" modified="2021-09-29" version="1">MPVPSGSLSSAFDHRALPSSQGAAGPYEFTSTAGRHVVGNLRGFRFVEESRTPTQAKSETRAAAVSRRRRDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GMD3</accession>
    <name>A0A836GMD3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF962 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_01654</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059393.1">
        <property type="nucleotide sequence ID" value="XM_067203702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GMD3"/>
    <dbReference type="GeneID" id="92357636"/>
    <dbReference type="KEGG" id="loi:92357636"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046521">
        <property type="term" value="P:sphingoid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009305">
        <property type="entry name" value="Mpo1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28026:SF9">
        <property type="entry name" value="2-HYDROXY-PALMITIC ACID DIOXYGENASE MPO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28026">
        <property type="entry name" value="DUF962 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G05310)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06127">
        <property type="entry name" value="Mpo1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5466503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="22791" checksum="93675E7FB206DEA1" modified="2021-09-29" version="1">MLAYVENYFDLRKSFVFYGAYHHNWKNQMIHVLFVPVIFTTALSFLARVPITGGVDLSHIVAVFYAISFIKMEPVAGALYLPVIAAMEYLGSKVLFDRVPTSIGIHVLGWAAQILGHKLAEGRQPAFTEDPLQAFHAAVFFVWLEVLFFLGYRPAEKAELEKLIRKRIANMNTVEATGKTPSAKGTPKTVRSSKSTGSVCIALKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GPW1</accession>
    <name>A0A836GPW1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">p-glycoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LSCM4_00862</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059580.1">
        <property type="nucleotide sequence ID" value="XM_067202930.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836GPW1"/>
    <dbReference type="GeneID" id="92356864"/>
    <dbReference type="KEGG" id="loi:92356864"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000836">
        <property type="entry name" value="ABC transporter B family member 25"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF27">
        <property type="entry name" value="ATP-DEPENDENT TRANSLOCASE ABCB1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="254"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="820"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="924"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="998"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="134"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="452"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="775"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1097"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG5467778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1341" mass="146185" checksum="7C8BC34950D4C823" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GPX7</accession>
    <name>A0A836GPX7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA ligase phosphodiesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_03320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060884.1">
        <property type="nucleotide sequence ID" value="XM_067205332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GPX7"/>
    <dbReference type="GeneID" id="92359266"/>
    <dbReference type="KEGG" id="loi:92359266"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003972">
        <property type="term" value="F:RNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057680">
        <property type="entry name" value="DUF7920"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015965">
        <property type="entry name" value="tRNA_lig_PDEase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32004">
        <property type="entry name" value="TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32004:SF1">
        <property type="entry name" value="TRNA LIGASE"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="61"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7920" evidence="3">
        <location>
            <begin position="363"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA ligase phosphodiesterase" evidence="2">
        <location>
            <begin position="827"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5471767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="910" mass="101196" checksum="8144C8F08EC94A2B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GR32</accession>
    <name>A0A836GR32_9TRYP</name>
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        <recommendedName>
            <fullName evidence="4">Guanine nucleotide-binding protein subunit beta-like protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">LSCM4_05769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="loi:92361633"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5479761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="448" mass="47380" checksum="11DF4C159ADE406A" modified="2021-09-29" version="1">MLRRIAYTSLPRDPQEVRLLHHTSGGVVIAAVRYTQSSSPLFFTVVEMTAPNEQALPLRVVHVRVPRPATVVSAITLARSADGADIYVIVQAAEKMNGNAASASVTSYVYRRQIVIDDEESGNGDEAHDHAAEDDVVSSPATSVVPAATRVRYQRLPRAFASADSAIWTAAAAFYPSESTLTDVRSSVDVAVIPTTAFITASGGGADSQLQLWQLCGARVTLEATWRVPALAGFAVQEILTLPGTQDVALLRHHNSIIEVNLSALRHACAYGSTVTGNAFLSRAWRWSAHEQLTACAVKDALLYAGTEGGAVLVWDLRKPTSTATAAGSCGGPPPLCSVALKTPITGLYAPYATGFITCDASGGVRDWRERDEAGVGENQNEEAEEGALRDVAGMAASAAAAATQFPYRSRAPVEVPTGEEGCVALDGHDNFAAMVGECGRLCLYFCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GRM2</accession>
    <name>A0A836GRM2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histone-binding protein RBBP4-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_02019</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061093.1">
        <property type="nucleotide sequence ID" value="XM_067204056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GRM2"/>
    <dbReference type="GeneID" id="92357990"/>
    <dbReference type="KEGG" id="loi:92357990"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022052">
        <property type="entry name" value="Histone-bd_RBBP4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050459">
        <property type="entry name" value="WD_repeat_RBAP46/RBAP48/MSI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22850">
        <property type="entry name" value="WD40 REPEAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12265">
        <property type="entry name" value="CAF1C_H4-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Histone-binding protein RBBP4-like N-terminal" evidence="4">
        <location>
            <begin position="245"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="144"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5472697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="505" mass="53684" checksum="B9B0BCAAB64BBEDE" modified="2021-09-29" version="1">MPGNKSHVDGRANGADDASSFPQLPPTRWGTEEPLSAAPPRGQMTRTQVLARLRRGKGSSTMAKPMLAAENDTGETSMRKMLKGRANGAEAHIRHEKSAETSSQAAAPLEVTTCSAASVIALHGEGSRNPAGATADGFDTVAASEEKGDAPQRGRRRHNRGTKIADDDAERNDAPGGSAGSVCDGDSGDEGSDSTSPARSGSADGANTAASSTHPIDVRVRRCVFSTRQTGNALPRMMALQRSFEAEARYLYEYCGMHLVEWPTLAVEWIPGRAFVDPERGYTLQYLASGTQAHPLSGAANTVKIMEVAVPITTASDAVYGLDGDDDAARAEAADFEVKSHLDPGKRFSNVKDHFHCEQTLTMDAAVLKIRAMPAETNIIAVKTASAFIGVYNLVQDLAQDLAQDLAQDETGQTVPDAVLRGHQLGGFGLCWNTLKPGFIASSADDGYVNYYDVSHRLTIDMRDASAVDSALAAPDTQPLERLVGHRDIVTDCSWHASQGHLLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GT91</accession>
    <name>A0A836GT91_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_00014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058207.1">
        <property type="nucleotide sequence ID" value="XM_067202106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GT91"/>
    <dbReference type="SMR" id="A0A836GT91"/>
    <dbReference type="GeneID" id="92356040"/>
    <dbReference type="KEGG" id="loi:92356040"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000073">
        <property type="entry name" value="Fructose-6-phosphate2-kinase/fructose-2,6-bisph os phatase-likeprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF36">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5464576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="485" mass="55067" checksum="5389415699B0F575" modified="2021-09-29" version="1">MVLVHLRGSNVYDMEGVNESNTIDFRHMVGVEHHTQREVVRPPPSLTGTEADRAAMESVGLYRFSNATNPVFIFVSSEERCSVPARFFCTRFVHYFRWIGESVQLFVASNSFQDHRPTPYATQRDMWLQENCRCVSAAVNYFDADPKLGFVATPVAVIFTDCDGADARHALVSLLPPDRSFLVRHVRFSEEWESHRSDLYSFIDVSLQRQALRASRSSGSVVCSSLTSFLNSMLPTLYQLYSEEPLEGAPGDTLKSFPPIFFTRHGQSEYNVEDRLGGDPDLTETGRIDAEDIARFFERQVKTNANLFDYRATVWEEDGDFEVWCSQLRRTQRTAQPTADVLSRGVLKPFKSLNEIHAGICEDMTNEEVKSLYPFIQLFRHTDKVGFRYPDGESYVDLVRRLTPLLNDLNNCTKCVVVVAHQAVLRTMLSFFGGRPVEEAVHVPCPQRTIWVCTMNRLGEPQLAEISLSPRKSPGGHPPASWEGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GTD1</accession>
    <name>A0A836GTD1_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_00091</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058282.1">
        <property type="nucleotide sequence ID" value="XM_067202181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GTD1"/>
    <dbReference type="GeneID" id="92356115"/>
    <dbReference type="KEGG" id="loi:92356115"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5464651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="76" mass="8418" checksum="B8D0A2C5246840D1" modified="2021-09-29" version="1">MKLHKVGENTVKVAMREVGLNIRDLHLRSFLRSGAEEGLPEGGGEGGVAIMPGCVWKAADSRFWQQEAPLRRPCWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GTS1</accession>
    <name>A0A836GTS1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_00321</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058507.1">
        <property type="nucleotide sequence ID" value="XM_067202406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GTS1"/>
    <dbReference type="SMR" id="A0A836GTS1"/>
    <dbReference type="GeneID" id="92356340"/>
    <dbReference type="KEGG" id="loi:92356340"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000364">
        <property type="entry name" value="Glutathione peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592:SF78">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000303">
        <property type="entry name" value="Glutathion_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 5" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="4">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000303-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5464876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="152" mass="16892" checksum="F7B47A0ABF2360AC" modified="2021-09-29" version="1">MASIFAYSAVQGGKPVSLQKYSGYVTLIVNVASRCSLTSFNMEILNGVQQAYNPRRFTVLAFPCAQFANQEPLSNAEIAQWCKDIGLLFPVFDRVNVKGPSADPLFQMLRAQQGALAWNYTKYLCDRSGVPRRKLEPGCSMDALRQSIECIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GUE1</accession>
    <name>A0A836GUE1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phytoene synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_00383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058566.1">
        <property type="nucleotide sequence ID" value="XM_067202465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GUE1"/>
    <dbReference type="GeneID" id="92356399"/>
    <dbReference type="KEGG" id="loi:92356399"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000037">
        <property type="entry name" value="Phytoene synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5464935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="629" mass="69627" checksum="FEBC7E7DB067F760" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GVJ0</accession>
    <name>A0A836GVJ0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dynactin subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_01986</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061061.1">
        <property type="nucleotide sequence ID" value="XM_067204024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GVJ0"/>
    <dbReference type="SMR" id="A0A836GVJ0"/>
    <dbReference type="GeneID" id="92357958"/>
    <dbReference type="KEGG" id="loi:92357958"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
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        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5472665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="215" mass="23266" checksum="C78F35D1BABB8CDD" modified="2021-09-29" version="1">MQLQSGSARLVPPLMTSGALNPLVVRHARGCITSDSKEADRVTGSGLTNSYDDRDGTSSIAEGAYVDCRAVVHTDMTEFSIGAYFFVCAGAVLRPPVRVYVNQLSACAEPRVHVGSFVYVGEQVVCEAAEIGHMVRLDAQCVVSTGAHLSDGVWLLTRTWVPPEVALSPYTVYAGVPAAPVRKLNARSYQLLHMEFLRRRREASRRGVSLSSAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GX68</accession>
    <name>A0A836GX68_9TRYP</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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    <gene>
        <name evidence="1" type="ORF">LSCM4_06859</name>
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    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000017">
        <property type="protein sequence ID" value="KAG5481784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064144.1">
        <property type="nucleotide sequence ID" value="XM_067208770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GX68"/>
    <dbReference type="GeneID" id="92362704"/>
    <dbReference type="KEGG" id="loi:92362704"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5481784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="681" mass="71834" checksum="03C5FCD7F3031873" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GXH9</accession>
    <name>A0A836GXH9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphodiesterase</fullName>
            <ecNumber evidence="7">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_07323</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="7">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the cyclic nucleotide phosphodiesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="7"/>
    <dbReference type="EMBL" id="JAFHLR010000015">
        <property type="protein sequence ID" value="KAG5483106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064602.1">
        <property type="nucleotide sequence ID" value="XM_067209219.1"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A836GXH9"/>
    <dbReference type="GeneID" id="92363153"/>
    <dbReference type="KEGG" id="loi:92363153"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1300.10:FF:000025">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000043">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0140">cGMP</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDEase" evidence="8">
        <location>
            <begin position="585"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="665"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="665"/>
            <end position="669"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="669"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="705"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="706"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="706"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="706"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="819"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="819"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="871"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5483106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="923" mass="102216" checksum="968AD83254EE39DC" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GYD6</accession>
    <name>A0A836GYD6_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05688</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000016">
        <property type="protein sequence ID" value="KAG5482429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064435.1">
        <property type="nucleotide sequence ID" value="XM_067207621.1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="295"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="281"/>
            <end position="291"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5482429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="641" mass="69228" checksum="7416459136500670" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GZ42</accession>
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            <fullName evidence="5">Transmembrane protein</fullName>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG5467801.1"/>
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        </location>
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        </location>
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            <begin position="62"/>
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        </location>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="KAG5467801.1"/>
        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="252" mass="28391" checksum="CB239A93B1768678" modified="2021-09-29" version="1">MQTLRLCSFSLMRRRCGCLAGAALILCDLSNPVSTSMRHAASLYSSIPSSEDETIHGKGRKAAAPESEGAAAAAAASGTAETTSAPSADVDAAAKRMEVREAIIQEILSRDKVVFELKRQHELSMLRVEQNQARVLKDQEERGMYYEQNCNVHTFDTISVGLYSQRSTLYHTMSAERLRNLKVFLMVFSTLATCVYLYYRYMINPDWAYVERPMNMLGSRVMAVREQRWKHLTEAQQFDSLRGEDSEALSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H0V7</accession>
    <name>A0A836H0V7_9TRYP</name>
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            <fullName evidence="14">CNNM transmembrane domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="12" type="ORF">LSCM4_00994</name>
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        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Trypanosomatida</taxon>
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            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
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    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059710.1">
        <property type="nucleotide sequence ID" value="XM_067203060.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="loi:92356994"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010960">
        <property type="term" value="P:magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Jelly Rolls"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="9" id="KW-0732">Signal</keyword>
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    <keyword evidence="4 7 8" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032372297" description="CNNM transmembrane domain-containing protein" evidence="9">
        <location>
            <begin position="40"/>
            <end position="598"/>
        </location>
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        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
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        <location>
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            <end position="249"/>
        </location>
    </feature>
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        </location>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="598" mass="65302" checksum="E47B9047EB708C7C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H1Y6</accession>
    <name>A0A836H1Y6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sec16 Sec23-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_06054</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SEC31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000011">
        <property type="protein sequence ID" value="KAG5485416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065153.1">
        <property type="nucleotide sequence ID" value="XM_067207979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H1Y6"/>
    <dbReference type="SMR" id="A0A836H1Y6"/>
    <dbReference type="GeneID" id="92361913"/>
    <dbReference type="KEGG" id="loi:92361913"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007029">
        <property type="term" value="P:endoplasmic reticulum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
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        <property type="entry name" value="WD40_repeat_dom_sf"/>
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        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923">
        <property type="entry name" value="SEC31-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923:SF11">
        <property type="entry name" value="SECRETORY 31, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TPR_Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="HCP-like"/>
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    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
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        <location>
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        <source>
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        <source>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
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        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000010">
        <property type="protein sequence ID" value="KAG5485701.1"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5485701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="86" mass="9120" checksum="752B1489CFA75758" modified="2021-09-29" version="1">MTSQQHSLLEGALQSCSTPQPSLFSHCLLAAPAAEVAVSDMDSAGIDSARFASSDNCDTPRYIPCKARYAVGSTAVLVELLREMDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H3W2</accession>
    <name>A0A836H3W2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glycosyltransferase 61 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_05990</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000011">
        <property type="protein sequence ID" value="KAG5485354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065091.1">
        <property type="nucleotide sequence ID" value="XM_067207917.1"/>
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    <dbReference type="GeneID" id="92361851"/>
    <dbReference type="KEGG" id="loi:92361851"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049625">
        <property type="entry name" value="Glyco_transf_61_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007657">
        <property type="entry name" value="Glycosyltransferase_61"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961:SF38">
        <property type="entry name" value="PROTEIN O-LINKED-MANNOSE BETA-1,4-N-ACETYLGLUCOSAMINYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04577">
        <property type="entry name" value="Glyco_transf_61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 61 catalytic" evidence="10">
        <location>
            <begin position="436"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5485354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="650" mass="71799" checksum="017E48D3371FBA4A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">LSCM4_01811</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000022">
        <property type="protein sequence ID" value="KAG5479222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067203856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H484"/>
    <dbReference type="GeneID" id="92357790"/>
    <dbReference type="KEGG" id="loi:92357790"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5479222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="105" mass="12058" checksum="9D8E66403FB7F2E7" modified="2021-09-29" version="1">MLRACLWDHATLPYKPPSPCILFYLVPGDPVWRVSVPNARGEYPDLIPGLPYKEWHAIEPHYLQEYASPALNIHRSAEVAWEDLPTPPFDDFKRFLSPSENTVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H4E1</accession>
    <name>A0A836H4E1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Formyl transferase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_02909</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060481.1">
        <property type="nucleotide sequence ID" value="XM_067204929.1"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A836H4E1"/>
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    <dbReference type="KEGG" id="loi:92358863"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:methionyl-tRNA formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11138">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11138:SF5">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Formyl transferase N-terminal" evidence="2">
        <location>
            <begin position="346"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="812"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="935"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="988"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1029"/>
            <end position="1039"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5470215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1121" mass="120095" checksum="76309CDA006AFD60" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H5X3</accession>
    <name>A0A836H5X3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_03098</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060668.1">
        <property type="nucleotide sequence ID" value="XM_067205116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H5X3"/>
    <dbReference type="GeneID" id="92359050"/>
    <dbReference type="KEGG" id="loi:92359050"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="170"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="170"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5471551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="239" mass="26594" checksum="016B8625F88F7201" modified="2021-09-29" version="1">MMQRPLYDAQGQVPQYTRPPYNDGGYNMSRPMDGIPQHGYNQPPVNYYQQPQGYPMGNPMYNVPQGYPPMMPGYRSGRGRGGWYYPSAARGGYSNMRGGFRGGRGGFPVRRKKPFVGGTLETQREWERQTACCFNLQGSCKFGDGCRFLHHNVEGRACQFGVKCRVHGTAKEAASEAPEKESTLKKEEKAGEEKSQKAPEQKPEKVEETTPAKESEGATEKPPKAPEASEQAADAEKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H6Y9</accession>
    <name>A0A836H6Y9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_05138</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062411.1">
        <property type="nucleotide sequence ID" value="XM_067207108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H6Y9"/>
    <dbReference type="SMR" id="A0A836H6Y9"/>
    <dbReference type="GeneID" id="92361042"/>
    <dbReference type="KEGG" id="loi:92361042"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="103"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="18"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5476178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="220" mass="24005" checksum="359E82A11F005710" modified="2021-09-29" version="1">MDTTSTNLSAHAKPWVPNGSSQQQAQLQHPHSHSNQYSQDSALGSVQGAGMQRGMRARGSASNGSANMMGPAQHHHEYGSLNGLSHTMQQQQPQQPKLSATAAKLFVGQLPFECTEERLRNLFSAYGNVEHIHILRDNSNRSRGAAFITLSTVQEADTAIFTLHNRYRMLTNRAIQVSYAKNSPNISPFGTHSAVEVHQSNPTNPLPDIAGLATQAPRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H7L0</accession>
    <name>A0A836H7L0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N(6)-L-threonylcarbamoyladenine synthase</fullName>
            <ecNumber evidence="1">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">N6-L-threonylcarbamoyladenine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_03100</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">LSCM4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060670.1">
        <property type="nucleotide sequence ID" value="XM_067205118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H7L0"/>
    <dbReference type="SMR" id="A0A836H7L0"/>
    <dbReference type="GeneID" id="92359052"/>
    <dbReference type="KEGG" id="loi:92359052"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:tRNA N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd24132">
        <property type="entry name" value="ASKHA_NBD_OSGEP_like_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000141">
        <property type="entry name" value="Probable tRNA N6-adenosine threonylcarbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000295">
        <property type="entry name" value="Probable tRNA N6-adenosine threonylcarbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01446">
        <property type="entry name" value="Kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034680">
        <property type="entry name" value="Kae1_archaea_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF14">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Gcp-like" evidence="11">
        <location>
            <begin position="27"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="133"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5471553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="364" mass="39776" checksum="9467FDCCFC0AB66F" modified="2021-09-29" version="1">MKRTLSLGIEGSANKIGVGVVDQAGTVLSNVRETYITPPGTGFLPRETAIHHSQYVLQVIQRAMHDAAVTPADIDIISYTKGPGMGAPLTVGCTVAKTLSLLWGKPLVGVNHCIGHIEMGRVVTKSLNPVVLYVSGGNTQVIAYADCRYRIFGETIDIAVGNCLDRVARLLGISNDPAPGYNIEQKAKRGKCFIRLPYTVKGMDMSFSGILSYVEQLVHHPQFTEPDVCEVSDKRRKAAQPLTSAPVPAGETFNTDDICFSLQETIFAMLVEVTERAMSQIKASDVLIVGGVGCNERLQEMMQQMAAERGGRCFDMDQRYCIDNGCMIAYAGLLQYLSGSFTTMAEATITQRFRTDEVYVAWRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H949</accession>
    <name>A0A836H949_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leucine-rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063561.1">
        <property type="nucleotide sequence ID" value="XM_067207788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H949"/>
    <dbReference type="GeneID" id="92361722"/>
    <dbReference type="KEGG" id="loi:92361722"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="332"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5479850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="478" mass="51195" checksum="1CB5BB3E1AE52050" modified="2021-09-29" version="1">MLWSLADVYRQACSDAAVLPNSALVRCFAATNHAMPLQVLSLNHNLIGPRGLVALLPVLHECRHTLHSVDLSLNNLDNGSIRMLVRCFANGGFAALRRLELRGNLLTYQGGKCLIHWCEGLQTVRQARGSRDAGAGEASRKSAASLAAAAPSDALRSSLLSTEYWCDAADVHIDYIGIEDTAMPEMLQRALQQRIAAAIAGREARRLGDSLQRSSRISTHKSTLVADITDTADSQQHSSTGTDSIKMSVPEDLPASVGAHPPTLSLVDGRRDDIDEQHHHGGVKVAAAEAPQREIPCFLECDADMNLFRQSAYGDASAYSSVSAEAEESDASRYNSAHRSSSSTAVRAAGPPLTAHVYDEQQPLSGRRRSGSAAGILPFPCHSPREDSGSDVRRATSNMCPASLPFTSLHSSDALTLRPKEPSATQQQRESGHYSSPPPVQTALNILDEWALEAVDQATGGTGEKEDADGLPMWLVGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HAJ3</accession>
    <name>A0A836HAJ3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Dynein intermediate-chain-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LSCM4_05310</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein intermediate chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG5477918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067207257.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="loi:92361191"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036157">
        <property type="term" value="C:outer dynein arm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036158">
        <property type="term" value="P:outer dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Dynein intermediate chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001006">
        <property type="entry name" value="Dynein intermediate chain 1, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF11">
        <property type="entry name" value="DYNEIN AXONEMAL INTERMEDIATE CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
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    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 11" id="KW-0853">WD repeat</keyword>
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        <location>
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            <end position="552"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG5477918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="686" mass="75290" checksum="3E1CE7F5929C2B93" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HB05</accession>
    <name>A0A836HB05_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061401.1">
        <property type="nucleotide sequence ID" value="XM_067205464.1"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A836HB05"/>
    <dbReference type="GeneID" id="92359398"/>
    <dbReference type="KEGG" id="loi:92359398"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="578"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5473398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1027" mass="107652" checksum="6A60E082E4BE916C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HB96</accession>
    <name>A0A836HB96_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="3">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_06531</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3"/>
    <dbReference type="EMBL" id="JAFHLR010000019">
        <property type="protein sequence ID" value="KAG5480960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063961.1">
        <property type="nucleotide sequence ID" value="XM_067208449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HB96"/>
    <dbReference type="SMR" id="A0A836HB96"/>
    <dbReference type="GeneID" id="92362383"/>
    <dbReference type="KEGG" id="loi:92362383"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001577">
        <property type="entry name" value="Peptidylprolyl isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000053">
        <property type="entry name" value="Peptidylprolyl isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050754">
        <property type="entry name" value="FKBP4/5/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46512">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46512:SF1">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0697">Rotamase</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="5">
        <location>
            <begin position="56"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5480960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="432" mass="48175" checksum="FC53AAFCD2FFA53E" modified="2021-09-29" version="1">MSGQSAESSASSVSDDSQPPMEVVYPLNEEVEVPGTDGGLYKTVLVEGAGSQPVKGAKVTVHYVGQLLDGTKFDSSRDRGEYFEFTLGRGQVIKGWDKGVATMRIGEKALLKCSPDYAYGAAGSPPTIPANATLLFEVELFHWTREVDISAAKDKSLMMNVLKDGVDYENPEFESSVTMDLSIYVGEFDPENRERHTPAKVLTCWKVVVGVTPLPPHLEEFLFKMRRQEAAACRVRSDLIRNAVPEFAIPSSSERGDCDVTYVVEISELSRTKTYDFTGAAKIAEGEKRKNNGNDAFKAGNLDLAERFYRRAMEFVGQDYGFDDADKLECHRVRISVMGNLAQVLLMRSKYTESAEFSRKVLDLDTKNTKALFRLAKAQDGLQEWEEASKCVNDILAIEPGNADAASLKMRLQQERRDFDRKQKSLFKKMFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HC26</accession>
    <name>A0A836HC26_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ras-related protein Rab-7b</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_07091</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000018">
        <property type="protein sequence ID" value="KAG5481380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064059.1">
        <property type="nucleotide sequence ID" value="XM_067208996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HC26"/>
    <dbReference type="SMR" id="A0A836HC26"/>
    <dbReference type="GeneID" id="92362930"/>
    <dbReference type="KEGG" id="loi:92362930"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002682">
        <property type="term" value="P:regulation of immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01862">
        <property type="entry name" value="Rab7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000751">
        <property type="entry name" value="Rab family GTPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981">
        <property type="entry name" value="RAB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981:SF20">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB-7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="208"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00067801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5481380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="223" mass="23766" checksum="4070D8A2005FF05F" modified="2021-09-29" version="1">MSMKRQLLKIIILGDSGVGKTSLMHQYVNNVFDNRYKATIGADFLSKDVEVNGRVVTLQIWDTAGQERFQSLGSAFYRGADACILVFDVTQQESFAHVGSWLEEFSIQAGRRDSVLVGNKTDLEDRRQVASKTVQAWCAKQNAGAANASSGAGAGAGDSAASEIKYFEASAKENAGVEEAFVAVAQLALAKKATVEETVPMPQTVNLSQSQPAPTSTSSACSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HER9</accession>
    <name>A0A836HER9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_07602</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000012">
        <property type="protein sequence ID" value="KAG5484832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064944.1">
        <property type="nucleotide sequence ID" value="XM_067209484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HER9"/>
    <dbReference type="SMR" id="A0A836HER9"/>
    <dbReference type="GeneID" id="92363418"/>
    <dbReference type="KEGG" id="loi:92363418"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="7">
        <location>
            <begin position="19"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="555"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="96"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="304"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="402"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="555"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5484832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="879" mass="98453" checksum="82D0B60733E303BD" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HG73</accession>
    <name>A0A836HG73_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Guanine nucleotide-binding protein subunit beta-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_05240</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062493.1">
        <property type="nucleotide sequence ID" value="XM_067207190.1"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A836HG73"/>
    <dbReference type="GeneID" id="92361124"/>
    <dbReference type="KEGG" id="loi:92361124"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039241">
        <property type="entry name" value="Rrp9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19865">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19865:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="528"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="528"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="552"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5476260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="730" mass="78285" checksum="7F6C7EED31B52748" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HIE1</accession>
    <name>A0A836HIE1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PDEase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_06940</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000017">
        <property type="protein sequence ID" value="KAG5481863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064223.1">
        <property type="nucleotide sequence ID" value="XM_067208849.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92362783"/>
    <dbReference type="KEGG" id="loi:92362783"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDEase" evidence="4">
        <location>
            <begin position="1088"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="226"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="344"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="516"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="684"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1364"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1413"/>
            <end position="1443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1565"/>
            <end position="1585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="389"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="520"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="684"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="704"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1364"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1414"/>
            <end position="1424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5481863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1637" mass="172268" checksum="345C4BC20CD74F65" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HJC1</accession>
    <name>A0A836HJC1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Lanosterol synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_07766</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the terpene cyclase/mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000006">
        <property type="protein sequence ID" value="KAG5487277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065774.1">
        <property type="nucleotide sequence ID" value="XM_067209644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HJC1"/>
    <dbReference type="SMR" id="A0A836HJC1"/>
    <dbReference type="GeneID" id="92363578"/>
    <dbReference type="KEGG" id="loi:92363578"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000250">
        <property type="term" value="F:lanosterol synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016104">
        <property type="term" value="P:triterpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02892">
        <property type="entry name" value="SQCY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032696">
        <property type="entry name" value="SQ_cyclase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032697">
        <property type="entry name" value="SQ_cyclase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018333">
        <property type="entry name" value="Squalene_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01787">
        <property type="entry name" value="squalene_cyclas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764:SF20">
        <property type="entry name" value="LANOSTEROL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764">
        <property type="entry name" value="TERPENE CYCLASE/MUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13243">
        <property type="entry name" value="SQHop_cyclase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13249">
        <property type="entry name" value="SQHop_cyclase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01016">
        <property type="entry name" value="Prenyltransferase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Squalene cyclase N-terminal" evidence="6">
        <location>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Bates M.D."/>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10716"/>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="5.5.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the myo-inositol 1-phosphate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.5.1.4" evidence="7"/>
    <dbReference type="EMBL" id="JAFHLR010000014">
        <property type="protein sequence ID" value="KAG5483813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064752.1">
        <property type="nucleotide sequence ID" value="XM_067206943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HM06"/>
    <dbReference type="SMR" id="A0A836HM06"/>
    <dbReference type="GeneID" id="92360877"/>
    <dbReference type="KEGG" id="loi:92360877"/>
    <dbReference type="UniPathway" id="UPA00823">
        <property type="reaction ID" value="UER00787"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004512">
        <property type="term" value="F:inositol-3-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000040">
        <property type="entry name" value="Inositol 1-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000334">
        <property type="entry name" value="Inositol-3-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000069">
        <property type="entry name" value="Inositol-3-phosphate synthase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002587">
        <property type="entry name" value="Myo-inos-1-P_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013021">
        <property type="entry name" value="Myo-inos-1-P_Synthase_GAPDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11510">
        <property type="entry name" value="MYO-INOSITOL-1 PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01658">
        <property type="entry name" value="Inos-1-P_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07994">
        <property type="entry name" value="NAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015578">
        <property type="entry name" value="Myoinos-ppht_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0398">Inositol biosynthesis</keyword>
    <keyword evidence="14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myo-inositol-1-phosphate synthase GAPDH-like" evidence="17">
        <location>
            <begin position="307"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00070063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG5483813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="528" mass="57875" checksum="B24DE3AA88A948C7" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HNT7</accession>
    <name>A0A836HNT7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_07118</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000018">
        <property type="protein sequence ID" value="KAG5481406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064085.1">
        <property type="nucleotide sequence ID" value="XM_067209022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HNT7"/>
    <dbReference type="SMR" id="A0A836HNT7"/>
    <dbReference type="GeneID" id="92362956"/>
    <dbReference type="KEGG" id="loi:92362956"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045194">
        <property type="entry name" value="MGRN1/RNF157-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22996">
        <property type="entry name" value="MAHOGUNIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22996:SF3">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036836">
        <property type="entry name" value="RNase_bind_SBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="298"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5481406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="358" mass="38693" checksum="5D5A33961EC97DD3" modified="2021-09-29" version="1">MGAKNSTQRQGAQGRNGVGGRSTTAGRQAPSNMPPHLADQYDGNNSRHRNVAPGNNNTAQPPQSAPPPQQPQQSNRNSSPARNNGATSNSGNERGGVQEGQMVKMLATVEASTVSYVPATQVLTFYITSLCDSLTYEIHTGVKEFVQAGSVCYRPNKPKMEPVKTEIRGPQENRKIALKLDISSLEEKEKVYNKHYPKQMPCVIVLRYKTSELRRNGDGRDNHTEEEVQAEHTEHTSVDLAENPRRRVISQIVTAGGSAYTVENLYGADNDGVTPTSGNSGGAVMIGSTIEDDEDGLCVICLTNAKDTAVMPCRHMCMCKDCGEQLLMHKPVCPVCRAPISTLLHMPSMSNNATASAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HP19</accession>
    <name>A0A836HP19_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000020">
        <property type="protein sequence ID" value="KAG5480325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063656.1">
        <property type="nucleotide sequence ID" value="XM_067208016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HP19"/>
    <dbReference type="GeneID" id="92361950"/>
    <dbReference type="KEGG" id="loi:92361950"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39666:SF1">
        <property type="entry name" value="NUCLEAR PORE COMPLEX NUP2_50_61 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39666">
        <property type="entry name" value="RANBP2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5480325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="849" mass="91053" checksum="FA79D5527199B3BA" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HUE0</accession>
    <name>A0A836HUE0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 19">DNA topoisomerase 2</fullName>
            <ecNumber evidence="7 19">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">LSCM4_07300</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="17 19">Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 18 19">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6 19">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 19">Belongs to the type II topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="7 19"/>
    <dbReference type="EMBL" id="JAFHLR010000015">
        <property type="protein sequence ID" value="KAG5483085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064581.1">
        <property type="nucleotide sequence ID" value="XM_067209198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HUE0"/>
    <dbReference type="SMR" id="A0A836HUE0"/>
    <dbReference type="GeneID" id="92363132"/>
    <dbReference type="KEGG" id="loi:92363132"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000819">
        <property type="term" value="P:sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00187">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.268.10:FF:000010">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.40:FF:000022">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000110">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000092">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.670:FF:000001">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.199.10:FF:000002">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="entry name" value="Topoisomerase II, domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="entry name" value="Topoisomerase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050634">
        <property type="entry name" value="DNA_Topoisomerase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001154">
        <property type="entry name" value="TopoII_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031660">
        <property type="entry name" value="TOPRIM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169:SF50">
        <property type="entry name" value="DNA TOPOISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169">
        <property type="entry name" value="DNA TOPOISOMERASE/GYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16898">
        <property type="entry name" value="TOPRIM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01158">
        <property type="entry name" value="TOPISMRASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00418">
        <property type="entry name" value="TPI2FAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="Type II DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52040">
        <property type="entry name" value="TOPO_IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14 18 19" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="15 18 19" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 18 19" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="21">
        <location>
            <begin position="434"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IIA-type catalytic" evidence="22">
        <location>
            <begin position="685"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1158"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="18">
        <location>
            <position position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00019635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00053943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU362094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS52040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAG5483085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1239" mass="139310" checksum="DD74D6AD17E3491A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836I109</accession>
    <name>A0A836I109_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_07423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000008">
        <property type="protein sequence ID" value="KAG5486490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065556.1">
        <property type="nucleotide sequence ID" value="XM_067209313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836I109"/>
    <dbReference type="SMR" id="A0A836I109"/>
    <dbReference type="GeneID" id="92363247"/>
    <dbReference type="KEGG" id="loi:92363247"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5486490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="365" mass="42201" checksum="E34A6EE4DE081698" modified="2021-09-29" version="1">MRRFSAPSVTALCVRSICGAAPVMYFPPVPFASVSKEEQVKRNTKIAIEMIRRSKGEAPASYTRKHTATIEQLEKEIEALLGGAQKMRKTTTDDQPMDKLTLMERCLRHALWSYHKDEGKYNFDEIAKWVVYTPEDEVKLAQLKRQVEAKSKLAAYRAKRAEKGLPDAPTPQTNWEEEYRSVTDRELVNEKRIRYDTLAANTMERDEAQIEAVLEQYRKPVQEKRLDDLVDLLERFKPVLAREAIMQRLTIKHLEGQLGVWRYMDWCPEVRDRAELEVDISGFQWWSPLEERRLLPVRLRSVNEVREIMAQTQSSKAAEASTHSPQTSQSAGDGDRERLLKEVLALQARIHQRDDAPAEEKKATH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836I198</accession>
    <name>A0A836I198_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutaredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_08308</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000001">
        <property type="protein sequence ID" value="KAG5488231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066278.1">
        <property type="nucleotide sequence ID" value="XM_067210177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836I198"/>
    <dbReference type="SMR" id="A0A836I198"/>
    <dbReference type="GeneID" id="92364111"/>
    <dbReference type="KEGG" id="loi:92364111"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03028">
        <property type="entry name" value="GRX_PICOT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033658">
        <property type="entry name" value="GRX_PICOT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004480">
        <property type="entry name" value="Monothiol_GRX-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293">
        <property type="entry name" value="GLUTAREDOXIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293:SF70">
        <property type="entry name" value="GLUTAREDOXIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032496998" description="Glutaredoxin domain-containing protein" evidence="4">
        <location>
            <begin position="21"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaredoxin" evidence="5">
        <location>
            <begin position="105"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5488231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="200" mass="21834" checksum="DADC46F55191F8BD" modified="2021-09-29" version="1">MQRAGMLMLSRNVLMRAVSAMAGTSSAKPPRRALFAPTRSLCGVSPVWLAPAAPTKGAPPATASDADLEETHPDFEPRLVARDLAEDEIAMVKKDILDTIRDEEIVVFIKGVPEAPMCAFSKRMIDVMEALGVEYTSFDVLAHPVVRSYVKEVSEWPTIPQAFVKGEFAGGVDIILKMAESGDLQMLLDQKGIKHRDTKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836I1A8</accession>
    <name>A0A836I1A8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Enkurin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_08323</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000001">
        <property type="protein sequence ID" value="KAG5488246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066293.1">
        <property type="nucleotide sequence ID" value="XM_067210192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836I1A8"/>
    <dbReference type="SMR" id="A0A836I1A8"/>
    <dbReference type="GeneID" id="92364126"/>
    <dbReference type="KEGG" id="loi:92364126"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027012">
        <property type="entry name" value="Enkurin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052102">
        <property type="entry name" value="Enkurin_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21490:SF2">
        <property type="entry name" value="ENKURIN DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21490">
        <property type="entry name" value="ENKURIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13864">
        <property type="entry name" value="Enkurin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51665">
        <property type="entry name" value="ENKURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enkurin" evidence="8">
        <location>
            <begin position="189"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="98"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="249"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5488246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="284" mass="30764" checksum="BAB18C3EC7F283B9" modified="2021-09-29" version="1">MPQNAAQLNRMQIREQEALNRQRRIQDEAVMRREAEAVRRTQSHYNYVASHGYGRTGGGGAAASPSSSPGASDEVQIRVYVRECDEGDSRSFCYRETTTASATSNTTGLRPAASESTSSASYGAGRGAVGSLPPISSSVRSKAPSAPRVSAASGGGGGSADISVGAASAVVVAPSRARVPRYLQQRKAELAAEKEAVAAELERQRQLSLIPAGQRRVSEAEKVDTLRQLDERQQELEGQLGRIPIRFDTQSIQQRRRAIEDELRQIEATRHTYTRKGALFVPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836I458</accession>
    <name>A0A836I458_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_08093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000005">
        <property type="protein sequence ID" value="KAG5487648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065936.1">
        <property type="nucleotide sequence ID" value="XM_067209969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836I458"/>
    <dbReference type="GeneID" id="92363903"/>
    <dbReference type="KEGG" id="loi:92363903"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5487648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="205" mass="22485" checksum="2D6F66743D15803B" modified="2021-09-29" version="1">MRRVSLSAIAASVSSSPSTSPAALLTLSRGFRKDLFEGPLDLKPGERNARKGPPVAHSLPVYKTTHKLHNSVRWKNANLVTNVAGGQDYRLRETQGEGTFDETGMYRDWLYGDERRYANYIGLTLGGLAIALFWYTMRVIGSETWDIPTPVLASQRKRLAKAAAEGDAYGSSEASAEVVLPPTEKEMRQDALAMLKRPVTVSKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836K6B2</accession>
    <name>A0A836K6B2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Fructose-bisphosphate aldolase</fullName>
            <ecNumber evidence="4 8">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_00129</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the class I fructose-bisphosphate aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="4 8"/>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058320.1">
        <property type="nucleotide sequence ID" value="XM_067202219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836K6B2"/>
    <dbReference type="SMR" id="A0A836K6B2"/>
    <dbReference type="GeneID" id="92356153"/>
    <dbReference type="KEGG" id="loi:92356153"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00948">
        <property type="entry name" value="FBP_aldolase_I_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000140">
        <property type="entry name" value="Fructose-bisphosphate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029768">
        <property type="entry name" value="Aldolase_I_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000741">
        <property type="entry name" value="FBA_I"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033379">
        <property type="entry name" value="FrucBisAld_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11627">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00274">
        <property type="entry name" value="Glycolytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00158">
        <property type="entry name" value="ALDOLASE_CLASS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5464689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="372" mass="40862" checksum="683DA7BD3672F17A" modified="2021-09-29" version="1">MSSRVDVLSCQLPAYNRLKTPYEQELIATVKKLTSPGKGLLAADESIGSCSKRFDPIGLSNTEEHRRQYRALMLEAEGLEQYISGVILHDETVSQKASNGQTFPMYLTGRGVVPGIKTDMGLCPLLEGAEGEQMTEGLDGYGKRASAYYKKGCRFCKWRNVYKIQNGTVSEAAVRFNAETLARYAILSQMSGLVPIVEPEVMIDGKHDIETCQRVSEHVWREVTAALQRHGVVWEGCLLKPNMVVPGAESGKKATPEQVAHYTVMTLARTMPAMLPGVMFLSGGLSEVQASEYLNAINKCPLPRPFFLSFSYARALQSSALKAWGGKESGIPAGRRAFLHRAKMNSLAQLGKYNRADDDASSSSLYVKGNTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836K7S3</accession>
    <name>A0A836K7S3_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059229.1">
        <property type="nucleotide sequence ID" value="XM_067203538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836K7S3"/>
    <dbReference type="GeneID" id="92357472"/>
    <dbReference type="KEGG" id="loi:92357472"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5466339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="460" mass="51215" checksum="6642A17F2245CF9A" modified="2021-09-29" version="1">MLGIQSWYTALAVPTIVIGGFVATRKRLAYQWREELMDPEGTAYPTVTDADMEFFRRVAPASAVAAAEEFAVPLHRLRAALQSTPAADSAAQEAYGVTLTAKENIGLCVQSNTLPPETRNVLLNEVGRLSKTLGNNVDPRKITAAKRSAQLAAAKEAEELYDTPARIPPSSSGSSSKCLDFDFLAHTRVIADHAEDIQLMKAPWGTGDGIRLAEMPASLRYLVERARQTFEGIGRLRHVYIEYSPTGQFYRTPKPPKMYDGHDYVVIPLRRDHRDVVVTMSPVLRSRVSDLREVMRHSWTNRDVDVLLPSGCMLRVYGTARYEWGWGIRPGPTWFGSRLNPVIPGKAASLDRGSDAGLWSRWKRALWPYSGTQHPTLTLSSLSCGAPTDAALIVLHYEGPRSSTKQRSLLLEPEVWIFGRAPSIESFDTWTEDRPTANAVEEEGLLRFLARNYLDMLTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836K931</accession>
    <name>A0A836K931_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U2A'/phosphoprotein 32 family A C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_00071</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058262.1">
        <property type="nucleotide sequence ID" value="XM_067202161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836K931"/>
    <dbReference type="SMR" id="A0A836K931"/>
    <dbReference type="GeneID" id="92356095"/>
    <dbReference type="KEGG" id="loi:92356095"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18849:SF0">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 410-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18849">
        <property type="entry name" value="LEUCINE RICH REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="152"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="230"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5464631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="28433" checksum="A6368661CA44D972" modified="2021-09-29" version="1">MSAEKVLSEKLVLEKTKVQSLGDVLRLDMWGEGLTDISLVAKLPRLEVLALAANNVSSLKPLQGCRMLQELYLRKNKLANLREVTALRALPALSVLWLRDNPCAQHPYYREFVLHCCPGLRQLDGVEVTAEERKAAGKRMTTKALDEILGRDASAEAVSSPRPKKTTGTGRIDCAKASDAAPSSTPAGTPDGTAIIEERSASGGTVLFTTVAAQRAMLLSIVSLLAELTVESLELLQREVHERIEKQKEKLTKYSQENSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KA96</accession>
    <name>A0A836KA96_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_02435</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060016.1">
        <property type="nucleotide sequence ID" value="XM_067204464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KA96"/>
    <dbReference type="GeneID" id="92358398"/>
    <dbReference type="KEGG" id="loi:92358398"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
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                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        <source>
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<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059493.1">
        <property type="nucleotide sequence ID" value="XM_067202843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KBM3"/>
    <dbReference type="GeneID" id="92356777"/>
    <dbReference type="KEGG" id="loi:92356777"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5467691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="761" mass="83151" checksum="B4FA805CEA2A5F53" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KCV6</accession>
    <name>A0A836KCV6_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060796.1">
        <property type="nucleotide sequence ID" value="XM_067205244.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92359178"/>
    <dbReference type="KEGG" id="loi:92359178"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35614">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35614:SF7">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="557"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="667"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="858"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="962"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1149"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1494"/>
            <end position="1535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1585"/>
            <end position="1622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1663"/>
            <end position="1700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1712"/>
            <end position="1797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1937"/>
            <end position="1966"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2017"/>
            <end position="2053"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2099"/>
            <end position="2137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2203"/>
            <end position="2255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="677"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1161"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1593"/>
            <end position="1612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1671"/>
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        </location>
    </feature>
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        <location>
            <begin position="1760"/>
            <end position="1769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1773"/>
            <end position="1787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1942"/>
            <end position="1952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2111"/>
            <end position="2127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2224"/>
            <end position="2236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5471679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="2416" mass="256464" checksum="B7DE52A9349BAD37" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KDR7</accession>
    <name>A0A836KDR7_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_02815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cyclase 1 superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060387.1">
        <property type="nucleotide sequence ID" value="XM_067204835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KDR7"/>
    <dbReference type="GeneID" id="92358769"/>
    <dbReference type="KEGG" id="loi:92358769"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5470121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="406" mass="44203" checksum="61634A9C57D726C4" modified="2021-09-29" version="1">MEAEFTELDEANRKVQEWKREAKQSAPVSLAGGVDLTMSLDDMQSATSPLSPFQVLRTSDILTQLVHIPSITTTAASSAVFGALLTLILTAQSSNTPVVRQGLVRRWMQRLLRLMISAVVSVMFLRFLRGRYPTVQRVSQYENLSRSPDCPCFVAKRILTVTSSQAGTHADGPHHFCRSLSGRNYDDAHYSGDAVVLDVGAELRQCQQSLAPDAPLAITAEVLEKARAKLPASFRDGSRPVWRLLLVTRHSTATGATSTGTPKAFSRPVRALLPMDGASSTRVDVSEMSRTAAVTLSESALSTYAFLHPGAVAYLHRVFPRLVLVGIDSPSVDPPQARLSHGALLRCGMAILENLRYTRLSPLLEGTSGDKQRGWLSGSMLTVFNATQNYDDARGCSVVFFPEEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KDV9</accession>
    <name>A0A836KDV9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha N-terminal protein methyltransferase 1</fullName>
            <ecNumber evidence="5">2.1.1.244</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">X-Pro-Lys N-terminal protein methyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LSCM4_02006</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54712"/>
            <dbReference type="Rhea" id="RHEA-COMP:13785"/>
            <dbReference type="Rhea" id="RHEA-COMP:13971"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138057"/>
            <dbReference type="ChEBI" id="CHEBI:138315"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-methionine = N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54736"/>
            <dbReference type="Rhea" id="RHEA-COMP:13787"/>
            <dbReference type="Rhea" id="RHEA-COMP:13974"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138059"/>
            <dbReference type="ChEBI" id="CHEBI:138318"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54724"/>
            <dbReference type="Rhea" id="RHEA-COMP:13789"/>
            <dbReference type="Rhea" id="RHEA-COMP:13973"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138061"/>
            <dbReference type="ChEBI" id="CHEBI:138317"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. NTM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.244" evidence="5"/>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067204043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KDV9"/>
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    <dbReference type="KEGG" id="loi:92357977"/>
    <dbReference type="Proteomes" id="UP000674143">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:N-terminal protein N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MeTrfase_NTM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12753:SF0">
        <property type="entry name" value="ALPHA N-TERMINAL PROTEIN METHYLTRANSFERASE 1"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF05891">
        <property type="entry name" value="Methyltransf_PK"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
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        <location>
            <position position="97"/>
        </location>
        <ligand>
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        <location>
            <position position="102"/>
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        <ligand>
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        <ligand>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00048167"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR016958-1"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="EMBL" id="KAG5472684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="250" mass="28142" checksum="E9EAAE18CE357B67" modified="2021-09-29" version="1">MSSEIMSSRGLPISGGDTNGKSYRSTDEMWKAELAGDLYDPEKGWYGKALEYWRNVPATVSGVLGGMDHIHDVDIKGSRSFIESLPDHGVSRALDCGAGIGRIAKSLLTKLYATTDLLEPVEHMLEEAKRELAGMPVGKFILASMETVKLPPNTYDLIVIQWTAIYLTDDDFVKFFKECQKSLTPNGYIFFKENCSTGDRFLVDKEDSSLTRSDRHYKRLFSESGVRVVKEAFQEDWPADLFPVKMYALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KFP5</accession>
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        <name type="scientific">Leishmania orientalis</name>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469070.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
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    </evidence>
    <sequence length="83" mass="8993" checksum="487AC1A1390E7A9D" modified="2021-09-29" version="1">MKMLKGYAFLENPGCSPAGVTAPSYAVSAPHARGQLPPGRERRMSLSTTLYLNSILLEAHKQVPWAAWWGRADNADPGSVKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836KFU4_9TRYP</name>
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        <recommendedName>
            <fullName evidence="7">Ankyrin repeat protein</fullName>
        </recommendedName>
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    <gene>
        <name evidence="5" type="ORF">LSCM4_03807</name>
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    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Discoba</taxon>
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            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061740.1">
        <property type="nucleotide sequence ID" value="XM_067205803.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="loi:92359737"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ANK"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="85"/>
        </location>
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    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="86"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5474634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="24496" checksum="8F5AFBE2F569D758" modified="2021-09-29" version="1">MEPYYEPDSEFREPLTDVDAFLDSARYNEAGDLDLLKAYLEKNPSDVDARDDQGRTAVHMAAANGHMSILEMLFQFNPQPNVPNDEGNTALHFAALNNRVAAAEALLAHGWRPSAQNVMGKTALQLIYEKQYNEMETLLMSCDDTLDSYVPPRQASVSVNLPAEEENDKRDEKSRKEAQAASERKVPPAKKTASAASEAPAPVVPVDATTGAQMLGSASVEDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KFX0</accession>
    <name>A0A836KFX0_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061800.1">
        <property type="nucleotide sequence ID" value="XM_067205863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KFX0"/>
    <dbReference type="GeneID" id="92359797"/>
    <dbReference type="KEGG" id="loi:92359797"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="402"/>
        </location>
    </feature>
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            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cyclase 1 superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060977.1">
        <property type="nucleotide sequence ID" value="XM_067205425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KIF6"/>
    <dbReference type="GeneID" id="92359359"/>
    <dbReference type="KEGG" id="loi:92359359"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31118">
        <property type="entry name" value="CYCLASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31118:SF12">
        <property type="entry name" value="CYCLASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5471860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="19943" checksum="70BACD60BDA27576" modified="2021-09-29" version="1">MRLVDLSLPLYDGMPVYNGDPQARVTKVCTREKNGWEVRQLQIDSHTGTHVDAPIHMHEGGSNLDEIPLTRFCGRAVVATAAAPSFPPNTGLLFHEAVPAECVPRIVSAKAPFVRGPLEEAERLLPSHRDVSLHRPRDRGGAHWRVAHVLRTSAAYSGRRWLAGARGGCHRRQVGRQRTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KJ85</accession>
    <name>A0A836KJ85_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062504.1">
        <property type="nucleotide sequence ID" value="XM_067207201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KJ85"/>
    <dbReference type="GeneID" id="92361135"/>
    <dbReference type="KEGG" id="loi:92361135"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5476271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="58" mass="5776" checksum="2787FEAAB0453B81" modified="2021-09-29" version="1">MSKVSVQRSGQVEMPSESLASAAGAAACIAAATVVCLNVSRLQSQPSQGTSRAVGRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KJH4</accession>
    <name>A0A836KJH4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DRBM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_01050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059765.1">
        <property type="nucleotide sequence ID" value="XM_067203115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KJH4"/>
    <dbReference type="SMR" id="A0A836KJH4"/>
    <dbReference type="GeneID" id="92357049"/>
    <dbReference type="KEGG" id="loi:92357049"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058737">
        <property type="entry name" value="DSRM_REH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42260:SF2">
        <property type="entry name" value="DRBM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42260">
        <property type="entry name" value="DRBM DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26536">
        <property type="entry name" value="DSRM_REH2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DRBM" evidence="3">
        <location>
            <begin position="1164"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="250"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="645"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="839"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="645"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="660"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="862"/>
            <end position="878"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5467963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1279" mass="137829" checksum="F21235C2F17403E1" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KKC5</accession>
    <name>A0A836KKC5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dynein arm light chain, axonemal</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_05095</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062370.1">
        <property type="nucleotide sequence ID" value="XM_067207067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KKC5"/>
    <dbReference type="SMR" id="A0A836KKC5"/>
    <dbReference type="GeneID" id="92361001"/>
    <dbReference type="KEGG" id="loi:92361001"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019347">
        <property type="entry name" value="Axonemal_dynein_light_chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13183:SF2">
        <property type="entry name" value="ARM LIGHT CHAIN, AXONEMAL, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13183">
        <property type="entry name" value="AXONEMAL INNER ARM DYNEIN LIGHT CHAIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10211">
        <property type="entry name" value="Ax_dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="133"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="448"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="133"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5476137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="475" mass="50534" checksum="B8BF0C92FFD83BFE" modified="2021-09-29" version="1">MAVPEGRSIYEALGTVLYCTIPVNVDDADDANPLRKQQRQQKQWCDAEIPLDYDAALALREIDEATMAARYMATKTRGAASATAGCAASRDGINVADRVSSATTVRASVAAPVAGPVPPQRSGMVSPLSARYGAASSSGGPPSALKAGQHVRTGGSISSNTSAAVFRSGAEVGGGQWEVSDTVDIPAKNARFVKTRMRAAAAAAAKTGSGTIAAGAPSRSARGASVSDTLTVAQAMEILFPIEAVCGGNGGRDDSAKDSEAEAADGAPTSQISASPLEALGAAADTTAAAAPRAPVMWRRADVAHLSRLDVVLLYQHLQRRCATESARPRGVVCPNRERIYNDGLRELIRQVTLLCPERGLLLDELARSMRQSIETYDVLLDSASQYAVRKSTERDLHQHLFAEKAALETEVRRREHRVSEWRAKYAGLQKRFQEQQAADSKLHAEEIAYAKRANQQLISEIKRLASEAEKAKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KLF6</accession>
    <name>A0A836KLF6_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_04586</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062778.1">
        <property type="nucleotide sequence ID" value="XM_067206569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KLF6"/>
    <dbReference type="GeneID" id="92360503"/>
    <dbReference type="KEGG" id="loi:92360503"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5477367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="296" mass="32294" checksum="BC13BF8E9FCB032E" modified="2021-09-29" version="1">MGRLPPRGSCSRSSLLFSFASLRQPQLPLSAYLHWHTITAATDSTTPASAEKVHLPSVICVSPAAFSVFVPPSVSPCSTHRRCADSPSSLVASAPRLALEHTAPAALFAFSSHFSPPDCLRSLFPLGLPAPHGKQGAGDKAATGEVRLRCQCAGARELLSPKAKAKCTEHPKGRLALRQAHWLVVHGERSCVRCDADLSRAPLRQVRGREHVAGTGVQVDLAEAQREGLRAVHDTAQEYVDGMARPEALQHQRRRERRRDPEVPMRWLLPLPLLLLRSFPLRMLSVGTHADGRRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KM08</accession>
    <name>A0A836KM08_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Acyl carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LSCM4_04102</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062028.1">
        <property type="nucleotide sequence ID" value="XM_067206091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KM08"/>
    <dbReference type="SMR" id="A0A836KM08"/>
    <dbReference type="GeneID" id="92360025"/>
    <dbReference type="KEGG" id="loi:92360025"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000035">
        <property type="term" value="F:acyl binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000029">
        <property type="entry name" value="Acyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00517">
        <property type="entry name" value="acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002148">
        <property type="entry name" value="PRK00982.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="ACYL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863:SF28">
        <property type="entry name" value="ACYL CARRIER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12 13" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 13" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032941044" description="Acyl carrier protein" evidence="14">
        <location>
            <begin position="22"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="15">
        <location>
            <begin position="72"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG5475520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="150" mass="16468" checksum="D90272B39D12D9E5" modified="2021-09-29" version="1">MQRLLIRRLGVRLAFPLVAAAARPSQLQASVCVGTAAYCGVVPSLKCSLRMYSGGQHEDQGARSGQYLLDKNDVLTRVLEVVKNFEKVDASKVTPESHFVNDLGLNSLDVVEVVFAIEQEFILDIPDHDAEKIQSIPDAVEYIAQNPMAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KM21</accession>
    <name>A0A836KM21_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stress-response A/B barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_04147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062073.1">
        <property type="nucleotide sequence ID" value="XM_067206136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KM21"/>
    <dbReference type="SMR" id="A0A836KM21"/>
    <dbReference type="GeneID" id="92360070"/>
    <dbReference type="KEGG" id="loi:92360070"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013097">
        <property type="entry name" value="Dabb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37832">
        <property type="entry name" value="BLL2683 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37832:SF1">
        <property type="entry name" value="STRESS-RESPONSE A_B BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00886">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stress-response A/B barrel" evidence="1">
        <location>
            <begin position="24"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5475565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="127" mass="14178" checksum="09E0E910AD46BC71" modified="2021-09-29" version="1">MEIDAANANEVAHPMSLNPRVNSVCHCAHLTLKGPLQVDKLRELLKRVRSSVPGLIEIHFGENMKTPAHRMDCGEGSTHALFSRHQNGHYLKMYHTHPARVALMNYLMSKAERPAAEVNFVNIASSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KPH0</accession>
    <name>A0A836KPH0_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
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                <person name="Bates M.D."/>
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                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062491.1">
        <property type="nucleotide sequence ID" value="XM_067207188.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="92361122"/>
    <dbReference type="KEGG" id="loi:92361122"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:gonad development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="AMH_N"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38827">
        <property type="entry name" value="T. BRUCEI SPP.-SPECIFIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04709">
        <property type="entry name" value="AMH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anti-Mullerian hormone N-terminal" evidence="1">
        <location>
            <begin position="44"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5476258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="125" mass="13537" checksum="A9D50AA3203F9E74" modified="2021-09-29" version="1">MFGRRVFGSTAIPRTMYARLHISSQAQAARMLPVLVPLTPSLSQSVGGMMNALTQGSLESMPTLEVGEQDPASLKALLESISPLQLGFSRLFELWGITRVTVMGNSIWGRLAAIPFDCCVCKHSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KU92</accession>
    <name>A0A836KU92_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_07231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000015">
        <property type="protein sequence ID" value="KAG5483020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064516.1">
        <property type="nucleotide sequence ID" value="XM_067209133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KU92"/>
    <dbReference type="GeneID" id="92363067"/>
    <dbReference type="KEGG" id="loi:92363067"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5483020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="453" mass="49471" checksum="26CD39D670D0E7DB" modified="2021-09-29" version="1">MSQSEAAVPAPPPPEEPLAYPITFSKLEEERSHSQAGAARTSSSSSLQQISIFSALHWLLPVYELAEWLPRAAVPHRTKSEKKSTSAIAPTGGSRSPRGISEDASVDLDAIPYDDVRAALRLLPVFEKFFAESNKIIPQHTDLYYFIESFTLPTPKGPKVITRSKVEGDYRATHQPSHAPSAPGTVGTTTKTTVTNSTAYFSLLPGHNQFLLYYEDSDKLRHFTYLQLDQLRFAWVAVKELLEENKVFNLNDGSLTGFAKRDLKKNNAASPFCLTSSAQAAAAVESAATSNGGAGGSSGSSSAVAGRGGGNARLHQGTSGNVITAPSREAMEEKKRMQQMRFLREELEHECQCRWPYTPVAKSCIFSVEEKIEAELPADALEQLGLVGAHNARNSKNGSRRGPRYYLATVELPLLNKKGGAARFKAPRWWNNRRDAESAAAEATLMALRSMKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KX21</accession>
    <name>A0A836KX21_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Kinetoplast-associated protein-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_06772</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000009">
        <property type="protein sequence ID" value="KAG5486065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065396.1">
        <property type="nucleotide sequence ID" value="XM_067208685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KX21"/>
    <dbReference type="GeneID" id="92362619"/>
    <dbReference type="KEGG" id="loi:92362619"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703">
        <property type="entry name" value="DYNEIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="227"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="30"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="573"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="255"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="351"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5486065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="761" mass="82994" checksum="EE87BDA8924FD212" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KXG4</accession>
    <name>A0A836KXG4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Anaphase-promoting complex subunit 4 WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LSCM4_07433</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">LSCM4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000008">
        <property type="protein sequence ID" value="KAG5486500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065566.1">
        <property type="nucleotide sequence ID" value="XM_067209323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KXG4"/>
    <dbReference type="SMR" id="A0A836KXG4"/>
    <dbReference type="GeneID" id="92363257"/>
    <dbReference type="KEGG" id="loi:92363257"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001912">
        <property type="entry name" value="Putative_intraflagellar_transport_protein_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000004">
        <property type="entry name" value="WD repeat-containing protein 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056158">
        <property type="entry name" value="Beta-prop_IFT121_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056159">
        <property type="entry name" value="Beta-prop_IFT121_TULP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057979">
        <property type="entry name" value="TPR_IFT121"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057361">
        <property type="entry name" value="TPR_WDR35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017233">
        <property type="entry name" value="WDR35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056170">
        <property type="entry name" value="Znf_IFT121-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15722:SF8">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 4-LIKE WD40 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15722">
        <property type="entry name" value="IFT140/172-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23390">
        <property type="entry name" value="Beta-prop_WDR35_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24797">
        <property type="entry name" value="Beta-prop_WDR35_TULP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25768">
        <property type="entry name" value="TPR_IFT121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25170">
        <property type="entry name" value="TPR_WDR35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23145">
        <property type="entry name" value="Zf_2nd_IFT121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037536">
        <property type="entry name" value="WD_repeat_p35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="IFT121/TULP4 N-terminal" evidence="11">
        <location>
            <begin position="1"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="IFT121 second beta-propeller" evidence="10">
        <location>
            <begin position="329"/>
            <end position="646"/>
        </location>
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        <source>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <sequence length="77" mass="8619" checksum="6D2DB2CB44FF956C" modified="2021-09-29" version="1">MTARGLEKPIQLITLELWCPATRSPHTFAGITHWSVVRIAFARLYVGTEITPRDDTWVRIALTLTSRLERSSPKGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
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                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">LSCM4</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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            <end position="1731"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="12">Sre-2/carboxylate carrier-like protein</fullName>
        </recommendedName>
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    </gene>
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    <reference evidence="10 11" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
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                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">LSCM4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sideroflexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000005">
        <property type="protein sequence ID" value="KAG5487628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Chromosome 5"/>
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        <property type="term" value="C:mitochondrial inner membrane"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="SIDEROFLEXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03820">
        <property type="entry name" value="SFXNs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
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        <location>
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            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5487628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="346" mass="38017" checksum="C5996FC7FB605A35" modified="2021-09-29" version="1">MKQLSTDATLGEVPRFPQDLQSDQSTYRGRFLHFLSMTDPRTLFTSPTRLALSEALLERVDRREEGWATVKVADYLDARQRVQCIIHPESKRPILLPFRFSAFVPMNFINLCGMLAPSQQTPARAMFWQFSNQTYNVGFNYCNGSGKDGLALHELAMGYVVATCTACGTSYRLSKAAAALSTSTSSSAPFLKLMIPYTAVACANMANLGVIRFRDVLRGIAVQDPETGKDLNDGKPSAIAGRLAVAQVALSRVIIPVPLMLLPPVFMGFLFHPTKGIRFFAQRSAQLYQPVNVLTLVSVLCVALPMSIAVFPQKTVVPVSWLEAPFQGQTNAAGHPIMHVEFNKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FL19</accession>
    <name>A0A836FL19_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_00015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058208.1">
        <property type="nucleotide sequence ID" value="XM_067202107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836FL19"/>
    <dbReference type="SMR" id="A0A836FL19"/>
    <dbReference type="GeneID" id="92356041"/>
    <dbReference type="KEGG" id="loi:92356041"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033016239" evidence="1">
        <location>
            <begin position="24"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5464577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="285" mass="31345" checksum="36A848706689AD73" modified="2021-09-29" version="1">MQQLQVWTCVLLLMVLCATTARGSKELLHGAWEVSTLVPGRGAVPPNYELTVQPGKWTVSERDSGRVGRFLDYAAARVGLVYTSVPSDEHALCHMPSSLILTLAAVRSDDGLRFECQTVWFTPSSLSAFEKDGLVHHRFDPAEPLYIADKGSCLATRWRVLEFYVARMGNDSFLFTGALVNGELGAGTPCSVHLEFRRRSIASATTPSPTSTCASIAMLLVVVAMRLLPRYILTRKGQLDKTSYRCKNPAGLTPAQRLQLLRRQREILEKMKAEDCANAAKGTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FM62</accession>
    <name>A0A836FM62_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prolyl endopeptidase</fullName>
            <ecNumber evidence="6">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_00722</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of Pro-|-Xaa &gt;&gt; Ala-|-Xaa in oligopeptides.</text>
            <dbReference type="EC" id="3.4.21.26"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peptidase S9A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="6"/>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058898.1">
        <property type="nucleotide sequence ID" value="XM_067202797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836FM62"/>
    <dbReference type="SMR" id="A0A836FM62"/>
    <dbReference type="GeneID" id="92356731"/>
    <dbReference type="KEGG" id="loi:92356731"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070012">
        <property type="term" value="F:oligopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.120:FF:000001">
        <property type="entry name" value="Prolyl endopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000005">
        <property type="entry name" value="Prolyl endopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.120">
        <property type="entry name" value="Prolyl oligopeptidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002471">
        <property type="entry name" value="Pept_S9_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023302">
        <property type="entry name" value="Pept_S9A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002470">
        <property type="entry name" value="Peptidase_S9A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051167">
        <property type="entry name" value="Prolyl_oligopep/macrocyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42881">
        <property type="entry name" value="PROLYL ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42881:SF2">
        <property type="entry name" value="PROLYL ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02897">
        <property type="entry name" value="Peptidase_S9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00862">
        <property type="entry name" value="PROLIGOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50993">
        <property type="entry name" value="Peptidase/esterase 'gauge' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00708">
        <property type="entry name" value="PRO_ENDOPEP_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S9A N-terminal" evidence="8">
        <location>
            <begin position="6"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="7">
        <location>
            <begin position="476"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5465267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="697" mass="77895" checksum="A6BD923160DD34D2" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FTE3</accession>
    <name>A0A836FTE3_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_02319</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5468927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059904.1">
        <property type="nucleotide sequence ID" value="XM_067204352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836FTE3"/>
    <dbReference type="GeneID" id="92358286"/>
    <dbReference type="KEGG" id="loi:92358286"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5468927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="352" mass="39007" checksum="372AB6AE65AE4DE3" modified="2021-09-29" version="1">MSEVVCKTAVNRRASLASRLPKKREVEPTASASLHRKVETTYDTAYVAHPAGAFASTRGAHVPTGSARAADGDASECRGQTYTLHHHPTSAWESTSHAAARNVHPERQRDFYASARKIEREDDDRRGGLVGRMQRSLDIRTKRAEDASLRPPTPTFRPVEMRSMQPAVAREIFGVKSSYLDLVECTQLKPETEEQIGYDDAPLKRLPGETLSQDLKVQSKIITQMGTSNELFRGTPKYLADTSVSYMGHVPMADHNVSGILHGDDARRLFAKSTMTMAEHGGGTDIAVIGSNIVTRHRGGKNAKAIRALQPKTINSINQTVEGRMLQQTLYGTLQRERQMNIRDDAQAHNYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FTF4</accession>
    <name>A0A836FTF4_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5468942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059919.1">
        <property type="nucleotide sequence ID" value="XM_067204367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836FTF4"/>
    <dbReference type="GeneID" id="92358301"/>
    <dbReference type="KEGG" id="loi:92358301"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5468942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="338" mass="37307" checksum="A8FF06363DD98B8B" modified="2021-09-29" version="1">MKAAQRVQFSLSKPRVEKLIVCLGLGDASEARESRGAVATRVSQQLLLRCRPSPSDVHNPDTTRAHARDRQGRPRSFYEAHTLQARRGRRGRTETLRGPQTWDSSRVVDFMGVWCDRLLLGDARHPSRCALLEPQVPEAMRGEAVARVAQSHRHLCSEDVLLVLAWETLPFGVVRLCTDAVVTESTSSSASSLTMPGIVTLPDALRLFKRSNVGPFRLHIGIGSEHGTSAPFAQHEALYVQRFLVPLCSFVVALWSANPAKASEYVASVAAKPESLTDGTANLRLWGTMQHSMLSTRDSAVLSAYYNDGVLDARLSRDHTRYLAETLLRRLTDGDDIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FYG4</accession>
    <name>A0A836FYG4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BPL/LPL catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_03193</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">LSCM4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the biotin--protein ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060759.1">
        <property type="nucleotide sequence ID" value="XM_067205207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836FYG4"/>
    <dbReference type="GeneID" id="92359141"/>
    <dbReference type="KEGG" id="loi:92359141"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin--[biotin carboxyl-carrier protein] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16442">
        <property type="entry name" value="BPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004408">
        <property type="entry name" value="Biotin_CoA_COase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00121">
        <property type="entry name" value="birA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12835">
        <property type="entry name" value="BIOTIN PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12835:SF5">
        <property type="entry name" value="BIOTIN--PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="3">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5471642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="263" mass="28479" checksum="55C5FAA3E929BA20" modified="2021-09-29" version="1">MLARFPPNIQFLEETTSTMDVARTLRATAGGKPFAVVAAVQTAGRGTGGRTWTSPKGNLYMTFGVPQQGQPPCIKEELVPVLSLICGLACRRAVLEVLHLDESSAKASLAAEAAKAVATKWPNDIIYKHKKVGGTLIESEEDCFIIGIGMNIAVAPQTTDAGREATMIDSIAEEYGVKSCTPQELANAIWRNFFEICTSPESTRASVIDSFDKVMDKSLKLHKRLPNGRDPEALTAVSLNSWGHLKVRHGDGTVEELSAEYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G1W2</accession>
    <name>A0A836G1W2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome P450 reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_01437</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059181.1">
        <property type="nucleotide sequence ID" value="XM_067203490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G1W2"/>
    <dbReference type="SMR" id="A0A836G1W2"/>
    <dbReference type="GeneID" id="92357424"/>
    <dbReference type="KEGG" id="loi:92357424"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000001">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF125">
        <property type="entry name" value="P450 REDUCTASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="Flavodoxin-like" evidence="9">
        <location>
            <begin position="79"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="10">
        <location>
            <begin position="385"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5466291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="823" mass="90069" checksum="F0372B48F3A17E0D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G328</accession>
    <name>A0A836G328_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_00739</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058915.1">
        <property type="nucleotide sequence ID" value="XM_067202814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G328"/>
    <dbReference type="GeneID" id="92356748"/>
    <dbReference type="KEGG" id="loi:92356748"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033062751" evidence="2">
        <location>
            <begin position="20"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5465284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="113" mass="12475" checksum="6EC38863595E77A9" modified="2021-09-29" version="1">MHIIEISRLLGCLSCAARAVLEYARPEDANGPSSKPVNSDVWYASMFMYPNHWQAGSGGALPLPGSPYRSFPIRSFLWGARDYIVSVLTILFVYFAVVLCFPPAAVEETVVTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G4R3</accession>
    <name>A0A836G4R3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_01058</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059773.1">
        <property type="nucleotide sequence ID" value="XM_067203123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G4R3"/>
    <dbReference type="SMR" id="A0A836G4R3"/>
    <dbReference type="GeneID" id="92357057"/>
    <dbReference type="KEGG" id="loi:92357057"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5467971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="528" mass="59273" checksum="3C62F925970626A4" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G6A2</accession>
    <name>A0A836G6A2_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_01323</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059069.1">
        <property type="nucleotide sequence ID" value="XM_067203378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G6A2"/>
    <dbReference type="GeneID" id="92357312"/>
    <dbReference type="KEGG" id="loi:92357312"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5466179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="157" mass="17089" checksum="DF1295C6246E2D36" modified="2021-09-29" version="1">MMACEMPTHCTAVVEDLPFFCLSFLAPSLAEPPPVFPSFLLIDTHTRARLYSNDAVVHFDEGPISANGVHALRTTTVHRFAGSNAAAVATTTVAASLYPVESFWRGPMEGLTAHVIPIFAVYDYEHQSVGGRRRAPTISFSDFSAQALPPPITHRPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G6V1</accession>
    <name>A0A836G6V1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_01675</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="5">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GcvH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059414.1">
        <property type="nucleotide sequence ID" value="XM_067203723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G6V1"/>
    <dbReference type="SMR" id="A0A836G6V1"/>
    <dbReference type="GeneID" id="92357657"/>
    <dbReference type="KEGG" id="loi:92357657"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000066">
        <property type="entry name" value="Glycine cleavage system H protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002270">
        <property type="entry name" value="PRK01202.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715:SF3">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 5" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="37"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="4">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617453-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5466524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="138" mass="15028" checksum="C3CFC1B4A36146AF" modified="2021-09-29" version="1">MRRAFTSLSVAAAASLRCYATKHFTDSHEWVEECGGEITIGITTYAQENLGDVVYVSLPQVGDTVTAKDVVGEVESVKATSNVYSPVDGTVTAVNEKLKDEPGLINHSPEEKGWLIKVKCSEMPKGLMDEAAYKKFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GB86</accession>
    <name>A0A836GB86_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">3-ketoacyl-CoA thiolase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_03258</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">LSCM4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060823.1">
        <property type="nucleotide sequence ID" value="XM_067205271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GB86"/>
    <dbReference type="GeneID" id="92359205"/>
    <dbReference type="KEGG" id="loi:92359205"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050521">
        <property type="entry name" value="3-ketoacyl-CoA_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42689">
        <property type="entry name" value="ACETYL-COA ACYLTRANSFERASE FADA2 (3-KETOACYL-COA THIOLASE) (BETA-KETOTHIOLASE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42689:SF1">
        <property type="entry name" value="ACETYL-COA ACYLTRANSFERASE FADA2 (3-KETOACYL-COA THIOLASE) (BETA-KETOTHIOLASE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="2">
        <location>
            <begin position="6"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="3">
        <location>
            <begin position="191"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5471706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="273" mass="29464" checksum="70C1484FB927A3B7" modified="2021-09-29" version="1">MLVEGEHADVVIAGGSDSVSNAELPLPRSVTHGLMMAQRKGIMGFFKEAGYNPSRWLPSGVALTERSTGKTMGWHGDVIGELNSISREDQEALAVASHANAARAEKAGYFSDEIVPVMVDATKNIEVKCDDVLQRDTEKMKAKMPSLKPVFRKDKGTITAATSSALTDGGSAMLVMSEEKAKKLGYPTDVSVKSWYFCGIDPYPQLLLAPVLGWGPALRKAGLAPKDIDLYEIHEAFAAQVLATIKCLRSQEFFDRYAGGGKPLSRKTLTGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GD68</accession>
    <name>A0A836GD68_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061197.1">
        <property type="nucleotide sequence ID" value="XM_067204160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GD68"/>
    <dbReference type="GeneID" id="92358094"/>
    <dbReference type="KEGG" id="loi:92358094"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5472801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="315" mass="35767" checksum="EE5252DA114F8717" modified="2021-09-29" version="1">MKFTHREIEEDRKKPVGSLFMHLMDRDSMPPRVHRNAAAQLLNAHSLPNTQLSLYAHDVPQRSSTPLRGRRHFPQKTRHVDFNSEDARPQRSMRRAATPNGNIDHICSNMTPRASTEVSTPRQRRYVPPPYRFSSNRPFWLGDDEIDASARRGRGTGSAMRSYSVGGQTHPGSKSCESHLTVGSLIPLPEKPVEKPTPPQLPIKPRRKGIRMFPEQRSRSADDARRGVRMVQPLPHWRSTAERQWDFLELGVARCETPVSLYRNESHVDVGGPNVSTEGLPASSAPLQRWRGGRRYGLTPYRRSFDIITGRPLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GGG9</accession>
    <name>A0A836GGG9_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_03774</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061707.1">
        <property type="nucleotide sequence ID" value="XM_067205770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GGG9"/>
    <dbReference type="SMR" id="A0A836GGG9"/>
    <dbReference type="GeneID" id="92359704"/>
    <dbReference type="KEGG" id="loi:92359704"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="860"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="821"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="20"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="860"/>
            <end position="890"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5474601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="929" mass="105817" checksum="7077BB9E204939D0" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GJ08</accession>
    <name>A0A836GJ08_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_03787</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061720.1">
        <property type="nucleotide sequence ID" value="XM_067205783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GJ08"/>
    <dbReference type="SMR" id="A0A836GJ08"/>
    <dbReference type="GeneID" id="92359717"/>
    <dbReference type="KEGG" id="loi:92359717"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904:SF523">
        <property type="entry name" value="STRESS-INDUCED-PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904">
        <property type="entry name" value="TPR REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="212"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5474614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="713" mass="79529" checksum="F9B8DEEF4EE9CAC2" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GJL0</accession>
    <name>A0A836GJL0_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062514.1">
        <property type="nucleotide sequence ID" value="XM_067207211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GJL0"/>
    <dbReference type="GeneID" id="92361145"/>
    <dbReference type="KEGG" id="loi:92361145"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5476281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="788" mass="86298" checksum="C0D123812BB011D5" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GK72</accession>
    <name>A0A836GK72_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">beta-ketoacyl-[acyl-carrier-protein] synthase I</fullName>
            <ecNumber evidence="2">2.3.1.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_02600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.41" evidence="2"/>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060179.1">
        <property type="nucleotide sequence ID" value="XM_067204627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GK72"/>
    <dbReference type="SMR" id="A0A836GK72"/>
    <dbReference type="GeneID" id="92358561"/>
    <dbReference type="KEGG" id="loi:92358561"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000081">
        <property type="entry name" value="3-oxoacyl-[acyl-carrier-protein] synthase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712:SF336">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="POLYKETIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="6">
        <location>
            <begin position="11"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5469202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="479" mass="49135" checksum="B5B01BD435D1F5C7" modified="2021-09-29" version="1">MGFGALPARTPRRVVVTGIGMVTPLGVTAMGTWAAVCRGQSGIRPLLEAPYFLPAFLQNDKTLSPQEKAAALKKLIAALPSKVAASVQPPPAVVSTSHTTGETPHASDPFAPSAHEPRALRLCACAVEEALSDAALQFSEALRDRCGVNIGMGIPSLADVTDVSVYLTGGAIATGAGQVQYGKVHPMFLPKILGNMAAGSTAICHKLRGPIGSSVAACATGAHCIGEAASWIREGRADVMVCGATEACITPVSVAGFSRMRALCTQYNDTPSSASRPFDKSRAGFVIGEGSGILILEALEHATARAAPHVYAELRGFGVSCDAHHMAVPHPEGIGARRCVEEALADGGDVPAAAVGYVNAHATGTIGDELELMAIQRALRPSKSPSSSALHVSSAKGGLGHLLGAAGSVEAALTVLALHEQRAPPTANLITSCLTPEQEECGLVCIQGSTAQRLQSCEAVISTSFGFGGMNTALLFTHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GK84</accession>
    <name>A0A836GK84_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_02615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060194.1">
        <property type="nucleotide sequence ID" value="XM_067204642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GK84"/>
    <dbReference type="GeneID" id="92358576"/>
    <dbReference type="KEGG" id="loi:92358576"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5469217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="115" mass="12494" checksum="09C746F2BED6C75C" modified="2021-09-29" version="1">MSQDSMYRHQLWHIEDPTLTVSQARLKLLFDFDPPSQYRLQPNGPLLHGIRPSCVLSGSVTPPGGNTAAPAAAPITVRRMGVFGRVGSAPVQYEEPLVAEWADVGLPPTSMKEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GKJ4</accession>
    <name>A0A836GKJ4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_04869</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DZIP C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000014">
        <property type="protein sequence ID" value="KAG5483717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064656.1">
        <property type="nucleotide sequence ID" value="XM_067206847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GKJ4"/>
    <dbReference type="GeneID" id="92360781"/>
    <dbReference type="KEGG" id="loi:92360781"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032714">
        <property type="entry name" value="DZIP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051241">
        <property type="entry name" value="DZIP_RILPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21502:SF9">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21502">
        <property type="entry name" value="ZINC FINGER PROTEIN DZIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13815">
        <property type="entry name" value="Dzip-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="160"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="176"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="282"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="367"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="672"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="94"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="241"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="295"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="402"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="450"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="475"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="555"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="568"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="593"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="680"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="700"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="738"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="775"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5483717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="792" mass="82001" checksum="AACB20D9B77F4912" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GL81</accession>
    <name>A0A836GL81_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_04398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062592.1">
        <property type="nucleotide sequence ID" value="XM_067206383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GL81"/>
    <dbReference type="SMR" id="A0A836GL81"/>
    <dbReference type="GeneID" id="92360317"/>
    <dbReference type="KEGG" id="loi:92360317"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5477181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="197" mass="22387" checksum="2B954918E5097C44" modified="2021-09-29" version="1">MRSSAIVLHRSAALARMRPTLRGTAPRAAWSRHRVQLLTSAVEAHAAFVPAIALSEQRRTQYAQMPGKRDQEAFLTQFDPLEVLDLPSDSTVEDIDAAFEKAKAKYGPKGRFPDAKMVDRAFRAYEILKDPDSPYYLKAHSSQTDRQRLQFQLLPKSKRRLIELQVCLLMLVVFVVAVLVIKLVLRPMNRSMRAATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GLP3</accession>
    <name>A0A836GLP3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LSCM4_02685</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 18">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 18">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5469997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060263.1">
        <property type="nucleotide sequence ID" value="XM_067204711.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836GLP3"/>
    <dbReference type="GeneID" id="92358645"/>
    <dbReference type="KEGG" id="loi:92358645"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08215">
        <property type="entry name" value="STKc_Nek"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000097">
        <property type="entry name" value="Probable serine/threonine-protein kinase nek1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000172">
        <property type="entry name" value="serine/threonine-protein kinase Nek1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051131">
        <property type="entry name" value="NEK_Ser/Thr_kinase_NIMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899">
        <property type="entry name" value="CAMK FAMILY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
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    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="4"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="289"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="511"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="829"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1070"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1106"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1187"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="330"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="361"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="397"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="511"/>
            <end position="533"/>
        </location>
    </feature>
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        <location>
            <begin position="626"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="637"/>
            <end position="655"/>
        </location>
    </feature>
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        <location>
            <begin position="677"/>
            <end position="688"/>
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        <location>
            <begin position="758"/>
            <end position="782"/>
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            <begin position="865"/>
            <end position="874"/>
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            <begin position="1111"/>
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            <end position="1326"/>
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            <end position="1370"/>
        </location>
    </feature>
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        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010886"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG5469997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1370" mass="148134" checksum="0BF90800E8B0FA96" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GLW0</accession>
    <name>A0A836GLW0_9TRYP</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_07974</name>
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        <name type="scientific">Leishmania orientalis</name>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG5484407.1"/>
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    </dbReference>
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    <dbReference type="GeneID" id="92363784"/>
    <dbReference type="KEGG" id="loi:92363784"/>
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        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5484407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="89" mass="10062" checksum="021A21FBB0856D89" modified="2021-09-29" version="1">MCASNRKRSTHFASSTRHNASPGMSAGTIYPPLYPRTVCRRMACLHQREGVRVLHPRWCRAVRWPASSGRREGKGAQRNRKTANVAQVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GLZ1</accession>
    <name>A0A836GLZ1_9TRYP</name>
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        <recommendedName>
            <fullName evidence="6">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="7" type="ORF">LSCM4_05213</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Kinetoplastea</taxon>
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            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067207164.1"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:deNEDDylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Nep1/2-like"/>
    </dbReference>
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        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
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        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="6">
        <location>
            <begin position="959"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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            <end position="97"/>
        </location>
    </feature>
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        <location>
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            <end position="235"/>
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        <location>
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        <location>
            <begin position="1212"/>
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        <location>
            <begin position="18"/>
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        </location>
    </feature>
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        <location>
            <begin position="32"/>
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        </location>
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        <location>
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        </location>
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        <location>
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        </location>
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        <location>
            <begin position="473"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1215"/>
            <end position="1234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5476234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1339" mass="143156" checksum="53E743BD1219E0F2" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GLZ7</accession>
    <name>A0A836GLZ7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_01072</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
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                <person name="Al-Salem W.S."/>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
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    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060087.1">
        <property type="nucleotide sequence ID" value="XM_067204535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GP18"/>
    <dbReference type="SMR" id="A0A836GP18"/>
    <dbReference type="GeneID" id="92358469"/>
    <dbReference type="KEGG" id="loi:92358469"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF70">
        <property type="entry name" value="TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="137"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="424"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5469110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="640" mass="71286" checksum="D2CD24CD0A7087D8" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GPZ8</accession>
    <name>A0A836GPZ8_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_01780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000022">
        <property type="protein sequence ID" value="KAG5479191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063284.1">
        <property type="nucleotide sequence ID" value="XM_067203825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GPZ8"/>
    <dbReference type="SMR" id="A0A836GPZ8"/>
    <dbReference type="GeneID" id="92357759"/>
    <dbReference type="KEGG" id="loi:92357759"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5479191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="252" mass="27561" checksum="E7B90B017E4397C8" modified="2021-09-29" version="1">MSSASFAVCQSADDTASEELKTFMAELNRLETASQSRARELAHAKAAERELSEQVAAVAFAAQKARHARLQTELKVAATQVGTEVARREAEEGRRQLGNIATQLESLNERRISLDSQKEQDQRGSRLCNPSRDFAAGETVAVSTAAVTTLPHAFVDDCKLCRSLTCVHGHTRLSNLFLVPLAQLLDKLRAQYTASLGDTHLLERAAPERRSLWWSDAFEVWLLERACGALTGDDMHALSFIASVKNGAPPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GQ47</accession>
    <name>A0A836GQ47_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000009">
        <property type="protein sequence ID" value="KAG5486117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065448.1">
        <property type="nucleotide sequence ID" value="XM_067208737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GQ47"/>
    <dbReference type="GeneID" id="92362671"/>
    <dbReference type="KEGG" id="loi:92362671"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5486117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="345" mass="36685" checksum="842B58B253BAA707" modified="2021-09-29" version="1">MLSDSPPRLAAAAAGDAVVLPSSPDDDSHPSMIRLTPTQVAKWTLKDVENHIFFVVWVCGIPVHVQYIVHLLEHSTVSTGRGREQTPHARSTRESLIAMAQADVLEPVCRRAAGLRHVLSRWPITATLPDPRSHEPSELVSLGVLSVAPEHEGCEIRPTERGECDEDGGSVKATASSSSSCFAIQAGAVTPAERFVNVAALALCSPAERECASLSSKPSATWCAQAYWTAVDQAQQWIAGWPSSSSGAARDTDSLGGTGAMPDSAWPHLQPECAWTSSRGKRPRGCDAPDTDDVVVVDEDEGEPRHNAGGAGLTSRAASDALHRSKASRCEMAEVVVIDSDEDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GQR7</accession>
    <name>A0A836GQR7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_04376</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062570.1">
        <property type="nucleotide sequence ID" value="XM_067206361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GQR7"/>
    <dbReference type="SMR" id="A0A836GQR7"/>
    <dbReference type="GeneID" id="92360295"/>
    <dbReference type="KEGG" id="loi:92360295"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16448">
        <property type="entry name" value="RING-H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969:SF69">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969">
        <property type="entry name" value="RING ZINC FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="726" mass="79873" checksum="C8433B7062839D11" modified="2021-09-29" version="1"> </sequence>
</entry>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="404"/>
            <end position="477"/>
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        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="KAG5478394.1"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="526" mass="57992" checksum="30E17271C6E1B130" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
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            </authorList>
            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <end position="537"/>
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        <source>
            <dbReference type="EMBL" id="KAG5479821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="720" mass="78240" checksum="EA0F1DA611FB9FC6" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GS82</accession>
    <name>A0A836GS82_9TRYP</name>
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    <reference evidence="4 5" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
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                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">LSCM4</strain>
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    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        </location>
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="4">OCRE domain-containing protein</fullName>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060000.1">
        <property type="nucleotide sequence ID" value="XM_067204448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GSA1"/>
    <dbReference type="GeneID" id="92358382"/>
    <dbReference type="KEGG" id="loi:92358382"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5469023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="18994" checksum="760886970C2C3CD2" modified="2021-09-29" version="1">MGCSGSKNKGARAVRPPESTANAVNRNAGTPPSAPQPRAASNAPPSREPEQIRENSSLPKNIKSPSNRSMETPAGQAASPNDANAIGTDAASTTAAAKVQRNNTSDISDGDEGDGSVTVVLPKGVWVKTEGTPYYYSVSENLYYHPPSCQFYDPTNEMWYDPEKDEWYHDDASDSDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836GSY8_9TRYP</name>
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        <recommendedName>
            <fullName evidence="3">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_08047</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
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            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000005">
        <property type="protein sequence ID" value="KAG5487602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067209923.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="92363857"/>
    <dbReference type="KEGG" id="loi:92363857"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42254:SF1">
        <property type="entry name" value="CALCINEURIN-LIKE PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42254">
        <property type="entry name" value="METALLOPHOS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5487602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="664" mass="71130" checksum="4D5247B1E4D14AE4" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GTH2</accession>
    <name>A0A836GTH2_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_00152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058342.1">
        <property type="nucleotide sequence ID" value="XM_067202241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GTH2"/>
    <dbReference type="GeneID" id="92356175"/>
    <dbReference type="KEGG" id="loi:92356175"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="818"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="818"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="862"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="876"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="887"/>
            <end position="896"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5464711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="928" mass="97882" checksum="5C52FA200D5247AA" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GTN3</accession>
    <name>A0A836GTN3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dipeptidyl-peptidase 8-like serine peptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_00257</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058447.1">
        <property type="nucleotide sequence ID" value="XM_067202346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GTN3"/>
    <dbReference type="SMR" id="A0A836GTN3"/>
    <dbReference type="GeneID" id="92356280"/>
    <dbReference type="KEGG" id="loi:92356280"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000016">
        <property type="entry name" value="Dipeptidyl peptidase 8-like isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.140.10.30:FF:000012">
        <property type="entry name" value="Dipeptidyl-peptidase 8-like serine peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.140.10.30">
        <property type="entry name" value="Dipeptidylpeptidase IV, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050278">
        <property type="entry name" value="Serine_Prot_S9B/DPPIV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731:SF193">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731">
        <property type="entry name" value="PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dipeptidylpeptidase IV N-terminal" evidence="2">
        <location>
            <begin position="168"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="1">
        <location>
            <begin position="630"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5464816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="851" mass="94437" checksum="A678FAB2D1FF924F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GV02</accession>
    <name>A0A836GV02_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">T4 RNA ligase 1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_00735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058911.1">
        <property type="nucleotide sequence ID" value="XM_067202810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GV02"/>
    <dbReference type="SMR" id="A0A836GV02"/>
    <dbReference type="GeneID" id="92356744"/>
    <dbReference type="KEGG" id="loi:92356744"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019039">
        <property type="entry name" value="T4-Rnl1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32004">
        <property type="entry name" value="TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32004:SF1">
        <property type="entry name" value="TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13671">
        <property type="entry name" value="AAA_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09511">
        <property type="entry name" value="RNA_lig_T4_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T4 RNA ligase 1-like N-terminal" evidence="1">
        <location>
            <begin position="69"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5465280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="905" mass="99068" checksum="8526037AC6F88CE8" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GX90</accession>
    <name>A0A836GX90_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Spindle assembly abnormal protein 6 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_01631</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059370.1">
        <property type="nucleotide sequence ID" value="XM_067203679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GX90"/>
    <dbReference type="SMR" id="A0A836GX90"/>
    <dbReference type="GeneID" id="92357613"/>
    <dbReference type="KEGG" id="loi:92357613"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd10142">
        <property type="entry name" value="HD_SAS6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.210.20:FF:000002">
        <property type="entry name" value="Hypothetical_protein_-_conserved"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.210.20">
        <property type="entry name" value="Spindle assembly abnormal protein 6, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053997">
        <property type="entry name" value="SAS-6_C_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032396">
        <property type="entry name" value="SAS-6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038558">
        <property type="entry name" value="SAS-6_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44281">
        <property type="entry name" value="SPINDLE ASSEMBLY ABNORMAL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44281:SF2">
        <property type="entry name" value="SPINDLE ASSEMBLY ABNORMAL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22218">
        <property type="entry name" value="SAS-6_C_CC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16531">
        <property type="entry name" value="SAS-6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spindle assembly abnormal protein 6 N-terminal" evidence="8">
        <location>
            <begin position="151"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="SAS-6 C-terminal coiled coil" evidence="9">
        <location>
            <begin position="270"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="719"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="299"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="389"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="550"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="741"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5466480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="813" mass="88869" checksum="0A588634691ABC25" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GXK9</accession>
    <name>A0A836GXK9_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058938.1">
        <property type="nucleotide sequence ID" value="XM_067203247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GXK9"/>
    <dbReference type="SMR" id="A0A836GXK9"/>
    <dbReference type="GeneID" id="92357181"/>
    <dbReference type="KEGG" id="loi:92357181"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039341">
        <property type="entry name" value="CFAP99"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34649">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 99"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34649:SF1">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 99"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="395"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="543"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5466048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="674" mass="76231" checksum="3073C83C338AEEFE" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GY94</accession>
    <name>A0A836GY94_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="7">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_01604</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="7">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="7"/>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059343.1">
        <property type="nucleotide sequence ID" value="XM_067203652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GY94"/>
    <dbReference type="SMR" id="A0A836GY94"/>
    <dbReference type="GeneID" id="92357586"/>
    <dbReference type="KEGG" id="loi:92357586"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17960">
        <property type="entry name" value="DEADc_DDX55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        </source>
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</entry>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836GZF9_9TRYP</name>
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        <name type="scientific">Leishmania orientalis</name>
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    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059798.1">
        <property type="nucleotide sequence ID" value="XM_067203148.1"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <keyword evidence="3" id="KW-0732">Signal</keyword>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5467996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836GZG7_9TRYP</name>
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        <name type="scientific">Leishmania orientalis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5468011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059813.1">
        <property type="nucleotide sequence ID" value="XM_067203163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GZG7"/>
    <dbReference type="GeneID" id="92357097"/>
    <dbReference type="KEGG" id="loi:92357097"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039963">
        <property type="entry name" value="Unchar_22kDa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38828">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38828:SF3">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5468011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="183" mass="21028" checksum="4327735F591A95AA" modified="2021-09-29" version="1">MAQGAEEYELATPGRVYLTPEQEEQLVDRLYTTSLSRKEMILAELDARFYPVAASHTISQETLQKSLQRQVDSEMERRQRRRQEIDAMVIFEAMGYANSKAATAAKKTLEPEEVDASVRRLYDETLSQKVAKMEQNERLYAFHPEDIKTVKMSKVALLDSVNRMSKPKKTTFTIAEVNKIYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GZH7</accession>
    <name>A0A836GZH7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cullin family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_03972</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061901.1">
        <property type="nucleotide sequence ID" value="XM_067205964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GZH7"/>
    <dbReference type="SMR" id="A0A836GZH7"/>
    <dbReference type="GeneID" id="92359898"/>
    <dbReference type="KEGG" id="loi:92359898"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cullin family profile" evidence="4">
        <location>
            <begin position="408"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5474795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="767" mass="87303" checksum="D17DFAEF66839076" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H1K9</accession>
    <name>A0A836H1K9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_03607</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061541.1">
        <property type="nucleotide sequence ID" value="XM_067205604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H1K9"/>
    <dbReference type="SMR" id="A0A836H1K9"/>
    <dbReference type="GeneID" id="92359538"/>
    <dbReference type="KEGG" id="loi:92359538"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000121">
        <property type="entry name" value="Putative GTPase activator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000026">
        <property type="entry name" value="TBC (Tre-2/Bub2/Cdc16) domain family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="478"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5473538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="783" mass="83308" checksum="55EEF68BC1684358" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H4C9</accession>
    <name>A0A836H4C9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_01874</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">LSCM4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ATG8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000022">
        <property type="protein sequence ID" value="KAG5479282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063375.1">
        <property type="nucleotide sequence ID" value="XM_067203916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H4C9"/>
    <dbReference type="SMR" id="A0A836H4C9"/>
    <dbReference type="GeneID" id="92357850"/>
    <dbReference type="KEGG" id="loi:92357850"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004241">
        <property type="entry name" value="Atg8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10969">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02991">
        <property type="entry name" value="ATG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4 5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="156"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="233"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="249"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="Phosphatidylserine amidated glycine; alternate" evidence="5">
        <location>
            <position position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604241-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5479282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="410" mass="42382" checksum="FA22F98D0E4EB9B8" modified="2021-09-29" version="1">MPRVGGGHASVGAAAPPNSSSPLPSSSSFSSAPYISPCECDNDEEGEGHHQSESKTASSTLSQATPQPTKDEGTSFSAKSPRALSSIPSFPGSATASSQRRPSLRGTTEGQAGARKRCQCAVSGSVPPCDASASPQGHSHTSASVAASCGRDRYALRSPSPTVTPPLLAPPSSLPLTTSSQVMGTPAPPPPPRTHYQYMHSFECRCLLSKKMRTLYGTGTVPVIVEPAESHLRLSPPPPLVQCEPRSSGGSGGNTGGYARHGGLSSSDHARASATVPAPASTFVSPSTKSTLKCVLPRSKSVADVILTLRGRLALDSCQSLFLSVGENDVLVPGSSLLGDLYERYRNPDGFLYLGYMLENTFGGDTRSSAGEAAAIPSGGEDRRTGRFMCVGGATVEEKASACTRTSTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H4S5</accession>
    <name>A0A836H4S5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000007">
        <property type="protein sequence ID" value="KAG5486841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065635.1">
        <property type="nucleotide sequence ID" value="XM_067208230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H4S5"/>
    <dbReference type="GeneID" id="92362164"/>
    <dbReference type="KEGG" id="loi:92362164"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5486841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="159" mass="18726" checksum="479BFCCB694FC720" modified="2021-09-29" version="1">MTEENNREQFSRYVLEISQAQRNHIADRVEQLAHHESLSWQYFFGCVTLSTGGVLAAFKMWGPRHIFKNSTYYARPLPPAISMGVALYGIMFTCRGMLMRNRICIMIEDYEYELKRVKAHHCEEGVTQLAWLEFVLDQVKQGSERRFDFQKLRESPVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H6J9</accession>
    <name>A0A836H6J9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000020">
        <property type="protein sequence ID" value="KAG5480467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063798.1">
        <property type="nucleotide sequence ID" value="XM_067208158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H6J9"/>
    <dbReference type="GeneID" id="92362092"/>
    <dbReference type="KEGG" id="loi:92362092"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5480467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="244" mass="26286" checksum="E242E0ACC6A806BB" modified="2021-09-29" version="1">MPVVDVSVLCATQITGVSLRNPFCVYVRLQGQAIRTNFSNADGAGEAHYSERFRFQYKPVANRSGRNRLFVELWTKSLFSQSCVSVAWMEMSEQHFVRGEQLHVNLRGTFEGKSATLSIAITPLDFGESSAVVQQAVPIAYGLPVEGVPLAPCNPYTSAAYMPNECAVVPDPASCRKAEAATGPPQPQAFVGASLPPPLYPSFSQDKQPPPPSSDGAGGQNPNALPASGQNADLDTRTHYTKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H7G3</accession>
    <name>A0A836H7G3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_06503</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000019">
        <property type="protein sequence ID" value="KAG5480932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063933.1">
        <property type="nucleotide sequence ID" value="XM_067208421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H7G3"/>
    <dbReference type="GeneID" id="92362355"/>
    <dbReference type="KEGG" id="loi:92362355"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="140"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5480932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="834" mass="89099" checksum="50A4ADDDD48413DD" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H7V6</accession>
    <name>A0A836H7V6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TFIIS N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_01794</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000022">
        <property type="protein sequence ID" value="KAG5479205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067203839.1"/>
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    <dbReference type="KEGG" id="loi:92357773"/>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051037">
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    </dbReference>
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        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
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        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010:SF1">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
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        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="62"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="154"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
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            <begin position="225"/>
            <end position="261"/>
        </location>
    </feature>
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        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="167"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5479205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="509" mass="54938" checksum="ED4C23B86083226D" modified="2021-09-29" version="1">MEEEDSILGLTPASAPVHADEKESASASVDLAAVLGRQAIAGAYADDGSGWSFEHALRAASAAAGDGDGSDAQSGRSSGADHEDGVASDAAEKNDEEQAGDVVDFRDAGAFCGAGGNVGAAEVCHMEDAELLSISDKKKAKRLGKKLYKRWKRLRKAAKSKKDREKGSKHKDSKRHSKGSHKRAGGSSHGKKGTKPRGDDDEEGMFLNMADGSSETHDELGLVPAADLSDAAAAIEARLQKAALRESKMRTEKAVKKATQRKSTAAELVTVSRELVAAMAKARRLDDDIISGRNAHPGSFPLNRVALKRIVQARCRQGYMVGPLVEAGILQELSYWLFDVDRAEPAPYELRTAALDILVSLPMEGSIPMTEDITAFMGVSREHLIKTDLGRALNALRRYSEETVENKGKCVQLLTSFSRVISGASDKDQTDEHKSKAAWKCQRDPTVASPFEVLETCSEAFQKSFMKPDPRDPTSYNGVLPWRPPAATITNVSGKLGDYIEKANIYPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H852</accession>
    <name>A0A836H852_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_03396</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneID" id="92359337"/>
    <dbReference type="KEGG" id="loi:92359337"/>
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        <property type="component" value="Chromosome 31"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="STKc_TLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000256">
        <property type="entry name" value="Serine/threonine-protein kinase TOUSLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
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    </dbReference>
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        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
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        <property type="entry name" value="MIXED LINEAGE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TOUSLED-LIKE KINASE, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ST"/>
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    </dbReference>
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    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="356"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5471838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="675" mass="75922" checksum="670691C58E7C8FA3" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HAH9</accession>
    <name>A0A836HAH9_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_07518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000004">
        <property type="protein sequence ID" value="KAG5487839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066036.1">
        <property type="nucleotide sequence ID" value="XM_067209404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HAH9"/>
    <dbReference type="SMR" id="A0A836HAH9"/>
    <dbReference type="GeneID" id="92363338"/>
    <dbReference type="KEGG" id="loi:92363338"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5487839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="165" mass="18498" checksum="AF43B5DE50634736" modified="2021-09-29" version="1">MSSSSSSVNKHGTNTTPPPLTPEERAARDARLQREHESYIRGIATMRSLPRLRSTIAGAGGKTNTNTRIAEEREELRQQHLRAAAAAAAEQQQRRQMHEEKVRRIESARAKKRNRRAAKKRKKKQRMEEKLRGRLDPLSDADSEDSASSSASASSSSYSDDDKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HGC7</accession>
    <name>A0A836HGC7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">(d)CMP kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_04560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062752.1">
        <property type="nucleotide sequence ID" value="XM_067206543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HGC7"/>
    <dbReference type="SMR" id="A0A836HGC7"/>
    <dbReference type="GeneID" id="92360477"/>
    <dbReference type="KEGG" id="loi:92360477"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5477341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="302" mass="32781" checksum="76218F2274526CAC" modified="2021-09-29" version="1">MQKATFQILREQDDVCSSCVLALLKDNAAFQHLSKSEGEDILKRDNEDAEKLSEGIRIAIRKGIVSGKPDVSPVTKVNVAGLSAQEVTDKILAALPSKNGNVIILQGLSGTGKGTTVSKLRDALPKCVTWSNGNIFRSYTYLCNEVLSAQGKEITEENLTDELLASVEKRVTFVKCDDGMFHTMLDGTTRVVDVQNTLLKTPLISSKVPTVAQQTQGEVIRFGSGAVKQLSADGYNVILEGRSQTLDYIASPLRFELVIPDVAVLGQRRAAQRVMAKALEMLSDSASDDEVDRILQKAVEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HGH4</accession>
    <name>A0A836HGH4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_04857</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000014">
        <property type="protein sequence ID" value="KAG5483705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064644.1">
        <property type="nucleotide sequence ID" value="XM_067206835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HGH4"/>
    <dbReference type="SMR" id="A0A836HGH4"/>
    <dbReference type="GeneID" id="92360769"/>
    <dbReference type="KEGG" id="loi:92360769"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000058">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1 2 3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="5">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="257"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5483705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="285" mass="32195" checksum="0234466BBBE074D2" modified="2021-09-29" version="1">MSHRYDSRTTTFSPEGRLYQVEYAVEAIQQAGIVIGVCTKDGVVLAGEKMVPHPLFDSENMQDKNTSGEKVYKIAEHIGCSVAGVTSDAYALLNYARLTAQRHQYAFQEPMAIEDLCRTLCDEKQLYTQYGGVRPYGVSFLLVGWDRYYGYQLYSTEPSGDYSAWSAYAIGQNDQVAQSLLKKDWHENMTLQDGILLALRVLSKTMDTAKIDLGRVEVALLHRVPAAGADRLLEPFKHQPKMVPQFHILSRCELKPHAERADQAREAEEQAEAERQRQQEQALES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HH41</accession>
    <name>A0A836HH41_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_06815</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000009">
        <property type="protein sequence ID" value="KAG5486107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065438.1">
        <property type="nucleotide sequence ID" value="XM_067208727.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836HH41"/>
    <dbReference type="GeneID" id="92362661"/>
    <dbReference type="KEGG" id="loi:92362661"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002589">
        <property type="entry name" value="Putative AAA family ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002932">
        <property type="entry name" value="Putative AAA family ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054472">
        <property type="entry name" value="WHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22977">
        <property type="entry name" value="WHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="918"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="1177"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="466"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="568"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="636"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="484"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="568"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="578"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="636"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5486107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1396" mass="151622" checksum="E1EFCBA23ACE0643" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HHN8</accession>
    <name>A0A836HHN8_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_07335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000008">
        <property type="protein sequence ID" value="KAG5486407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065473.1">
        <property type="nucleotide sequence ID" value="XM_067209230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HHN8"/>
    <dbReference type="GeneID" id="92363164"/>
    <dbReference type="KEGG" id="loi:92363164"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5486407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="302" mass="33120" checksum="07A5A8227ACDF707" modified="2021-09-29" version="1">MGGETHTPRGCLPLDTGAHHCAWGRNGTLEITEFFCDAAHSEGLLQCHVVSAPRKRCREENQEIDADPRHMPPHMRVQVAWENATSLVTLRGRVLDADGRFNAAEYPGLVFFYNPVVTCVASGTVTLHFDNSASVTERILQGGRQPPCPVHGPFRCPCHLMHEVADGVAMLLSEIFCQHAPFDVSIDCDRPYPHIHIDSQAKTWSLSLVGLPVPPKVFGPFPLGTSTSPQSIKKYWFQYIEKSKALADACIMCGTVPAARCAKCLCLLCQRCGEHCGACGSYFCHGCSTAESGMTLCYNCHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HJS3</accession>
    <name>A0A836HJS3_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000022">
        <property type="protein sequence ID" value="KAG5479231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063324.1">
        <property type="nucleotide sequence ID" value="XM_067203865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HJS3"/>
    <dbReference type="GeneID" id="92357799"/>
    <dbReference type="KEGG" id="loi:92357799"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="Multiheme cytochromes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5479231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="214" mass="23277" checksum="EF15080BCEEC61D7" modified="2021-09-29" version="1">MERPKTESEIQQEQSDELFARQLQEQLNNPNLSENATPPPTGPMKSLQEAADAALARQLQEEIDRQEEAAAADASSAGAAARVPVECPACTFVNHIKPSSSSRHWKCAQCREPLENVLHSSRTSDNDLVECKVCHSLNRPPSKKSDTVLCGRCYQELGASLSTAQPEESQANQRTVQLRCGQCNVINAVTVGADVKRMEFICGGCGVLNSIVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HK54</accession>
    <name>A0A836HK54_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Guanine nucleotide-binding protein subunit beta-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_06551</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000010">
        <property type="protein sequence ID" value="KAG5485595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065179.1">
        <property type="nucleotide sequence ID" value="XM_067208468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HK54"/>
    <dbReference type="GeneID" id="92362402"/>
    <dbReference type="KEGG" id="loi:92362402"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5485595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="36499" checksum="BD59E7AF2B2AF0B1" modified="2021-09-29" version="1">MLKECDFFSDSYGCIITKSIGYQAPFPLVRLSNGRSTTTPDGACVQGACFASSGVDHSTSRGRLLTVDVSAPASSVSFLQLLSRSCPPLALEQEVEYVSKIESTEAATAVVTRGGGSRWGTSVYVQSEDTQGTLCTRRAHFCGTHCASLFSSTLWVVEAVKYDTGAHAVHRYSLASALAGELCESTLMDADVGQPLDVIALSEDSALVLGSNGVAMTDRRKRGSDILFFSALLNGGATGDMQLLTFSEDYTLRAYDLRELSAPVSEATSASYLRIKSERGMRASLLVSSDMTGVFDVLRVTTIACLQHSGDTVLDAAILPSRHNGVRVCTSTGSGMVYDWTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HKA1</accession>
    <name>A0A836HKA1_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000010">
        <property type="protein sequence ID" value="KAG5485670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065254.1">
        <property type="nucleotide sequence ID" value="XM_067208543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HKA1"/>
    <dbReference type="GeneID" id="92362477"/>
    <dbReference type="KEGG" id="loi:92362477"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5485670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="521" mass="58120" checksum="C2E3A47D94E978FC" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HLU1</accession>
    <name>A0A836HLU1_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000022">
        <property type="protein sequence ID" value="KAG5479170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063263.1">
        <property type="nucleotide sequence ID" value="XM_067203804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HLU1"/>
    <dbReference type="SMR" id="A0A836HLU1"/>
    <dbReference type="GeneID" id="92357738"/>
    <dbReference type="KEGG" id="loi:92357738"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5479170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="244" mass="28168" checksum="5E4A5DE65AF845BE" modified="2021-09-29" version="1">MDKSQVTELIQRWRVLKGSLTEKGTELEAVHRSLQELESEHAKMVRQWDLEKETIRNTSSAIEAQVASKQDELQRIKQETQELHHKVEERRRRNEEHQRVLSKRKQMVDARSKEAEEKDAAVRERLATFQRSRDEARDRLLAAVQKHEAAIPQEQAAHEDKVRQIKSRIAETLAAIEAEAKSWALEQAMKEWNEKSNARKHILDEVAAAEEGKDTWADLLHEANSIHIQGNLTALAELRAMISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HPR8</accession>
    <name>A0A836HPR8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Sperm-associated antigen 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Protein PF16 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LSCM4_06245</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">LSCM4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Important for structural integrity of the central apparatus in the sperm tail and for flagellar motility.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with SPAG16 and SPAG17.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
            <location evidence="1">Flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000020">
        <property type="protein sequence ID" value="KAG5480478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063809.1">
        <property type="nucleotide sequence ID" value="XM_067208169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HPR8"/>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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            <end position="1346"/>
        </location>
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        </source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836K6A3</accession>
    <name>A0A836K6A3_9TRYP</name>
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            <fullName evidence="7">Plectin/eS10 N-terminal domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="8" type="ORF">LSCM4_00099</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
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    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG5464659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Ribosomal_eS10"/>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
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    </dbReference>
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    <feature type="compositionally biased region" description="Low complexity" evidence="6">
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF03501"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5464659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="169" mass="18601" checksum="60D803DD6A492BAC" modified="2021-09-29" version="1">MSTYVPKPSRDNVYRFFFTEGVIACKKDPMGTWTGTLGGSSFTVPCIQVMQLMRSLKSRNLIKEQYAWRHYYWTLNDEGIAYMRSYLHLAPSAMPNTQKPSSVNFEKVTEGRGRGRGRGGRGRGEGRGRGRGEGRGRGRGRGFGGERTNYRAAAAASPEGEAAPAPAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836K6D0</accession>
    <name>A0A836K6D0_9TRYP</name>
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        <recommendedName>
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        </recommendedName>
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        <name evidence="2" type="ORF">LSCM4_00190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="loi:92356213"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="15"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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        <location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1142"/>
            <end position="1160"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1178"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1267"/>
            <end position="1276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5464749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1660" mass="180396" checksum="B30DD3F12EABA69F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836K9D2</accession>
    <name>A0A836K9D2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Guanine nucleotide-binding protein subunit beta-like protein</fullName>
        </recommendedName>
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    <gene>
        <name evidence="7" type="ORF">LSCM4_00455</name>
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    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Kinetoplastea</taxon>
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            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058637.1">
        <property type="nucleotide sequence ID" value="XM_067202536.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="loi:92356470"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="WD_domain_-_G-beta_repeat/Utp21_specific_WD40_ass ociated_putative_domain_containing_protein_-_putative"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059157">
        <property type="entry name" value="WDR36-Utp21_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007319">
        <property type="entry name" value="WDR36/Utp21_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22840">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22840:SF12">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25171">
        <property type="entry name" value="Beta-prop_WDR36-Utp21_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25168">
        <property type="entry name" value="Beta-prop_WDR36-Utp21_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04192">
        <property type="entry name" value="Utp21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDR36/Utp21 N-terminal" evidence="6">
        <location>
            <begin position="31"/>
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        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="497"/>
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        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="588"/>
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        </location>
    </feature>
    <feature type="domain" description="WDR36/Utp21 C-terminal" evidence="5">
        <location>
            <begin position="775"/>
            <end position="976"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25171"/>
        </source>
    </evidence>
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        <source>
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        <source>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
            <dbReference type="SAM" id="Coils"/>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
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    </evidence>
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</entry>
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                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
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            </authorList>
            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Al-Salem W.S."/>
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            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="protein sequence ID" value="KAG5470106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.680">
        <property type="entry name" value="GOLD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051026">
        <property type="entry name" value="PI/PC_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657:SF1">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="381"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="621"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5470106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="767" mass="84929" checksum="145294E830CFD0A1" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KE14</accession>
    <name>A0A836KE14_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Reticulon-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_02174</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Endoplasmic reticulum membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061245.1">
        <property type="nucleotide sequence ID" value="XM_067204208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KE14"/>
    <dbReference type="SMR" id="A0A836KE14"/>
    <dbReference type="GeneID" id="92358142"/>
    <dbReference type="KEGG" id="loi:92358142"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009617">
        <property type="term" value="P:response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003388">
        <property type="entry name" value="Reticulon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045064">
        <property type="entry name" value="Reticulon-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10994">
        <property type="entry name" value="RETICULON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10994:SF193">
        <property type="entry name" value="RETICULON-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02453">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RETICULON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Reticulon" evidence="7">
        <location>
            <begin position="13"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5472849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="197" mass="22214" checksum="8B1AEA72C6CFF02C" modified="2021-09-29" version="1">MSAITKEFKGLTVKDAVTWHRPVASGVIFSLLFSIWAIFVFAEYTLTTFLSRIVTILFILGAAAAVTKRTVVASPEDVTASMDRAYEFVRPYVTKSVDWMVSLVTWRDYAVSAKFFLATFVTAFLGNWMSDTTLLLVVLLVSFTAPVAYEKKQKEIECVLMKAHAYADKYLGMIKTQASSKKETIEQQLHELERKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KE17</accession>
    <name>A0A836KE17_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061260.1">
        <property type="nucleotide sequence ID" value="XM_067204223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KE17"/>
    <dbReference type="GeneID" id="92358157"/>
    <dbReference type="KEGG" id="loi:92358157"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5472864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="353" mass="36771" checksum="478DB47BDA52E9C8" modified="2021-09-29" version="1">MDFAKAHIFTRENFRPITAPEDATSYFGMLSPPPSLPPLVKASKTKSREQVAASSESVAELKGDEAAGTEASSSPNLNPIITFVSTGTSGEESLKLASLTTRQLTLGLPDYGNSDPVPIQFNHLLQFVEAQMITASQAESLWDFFAVLPEVVRGGGCDSDAGGAGSSLSITSTREVWGRAARGDANGAAVERESSVLEVVEERPAMNGVAPGGVDAEESEIDDGRAFYVPHSPSQLPTSAMLAPALRRKISQQHSGHDAAVVHQPHKPQHNGHHWLGSSGASGGGGEGIDSGAGGVGGGHRTSPPKIRGLQKQLSITTEHGGEGGDEDDEGAGTFDTFSELVLPAGLKDDEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KE23</accession>
    <name>A0A836KE23_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061275.1">
        <property type="nucleotide sequence ID" value="XM_067204238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KE23"/>
    <dbReference type="SMR" id="A0A836KE23"/>
    <dbReference type="GeneID" id="92358172"/>
    <dbReference type="KEGG" id="loi:92358172"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000087">
        <property type="entry name" value="GTPase activator-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000048">
        <property type="entry name" value="TBC domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF27">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="1">
        <location>
            <begin position="26"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5472879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="363" mass="41404" checksum="FF37E22BBDF8548B" modified="2021-09-29" version="1">MDLNIDHILNAETVDFQALTRSCRRGLRESARPDCWKVIMGFYPTSTKHWAAIEAERLQEYSEVLEACGLGLESSKLEPNDVSRFIDVDVPRTMPSLNFFLADENRVETSRDDGTEEAARFTPSQHALRRILISTAMVNKSLGYVQGMNEYVAHLLYAFAKGKTSNVTPSVEADTFFCFQTLLAHLGDDFCRSFDFDAGCGLTSTMRLFDNVMRFFDPSLFEHLQYLGINAEHYALRWIMLLFMQEFNIADGLRVWDFLFSFGDKVRSAAFFVAAAMCHHLRSSILSGEVISDVLPLLQEYPPGDVNLFLRIAWKWIAKFDFDLLQELKQLSPEGVQALRRSHGLERGMSLVQVMQSWVPSVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KF48</accession>
    <name>A0A836KF48_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_03042</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060613.1">
        <property type="nucleotide sequence ID" value="XM_067205061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KF48"/>
    <dbReference type="SMR" id="A0A836KF48"/>
    <dbReference type="GeneID" id="92358995"/>
    <dbReference type="KEGG" id="loi:92358995"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="447"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="150"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="396"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="167"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="366"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="398"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="420"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5470347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="559" mass="60680" checksum="04822B585BD502AC" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KG20</accession>
    <name>A0A836KG20_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">tRNA (adenine(58)-N(1))-methyltransferase</fullName>
            <ecNumber evidence="2 8">2.1.1.220</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_04006</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>adenosine(58) in tRNA + S-adenosyl-L-methionine = N(1)-methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43152"/>
            <dbReference type="Rhea" id="RHEA-COMP:10365"/>
            <dbReference type="Rhea" id="RHEA-COMP:10366"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74491"/>
            <dbReference type="EC" id="2.1.1.220"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.220" evidence="2 8"/>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061935.1">
        <property type="nucleotide sequence ID" value="XM_067205998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KG20"/>
    <dbReference type="SMR" id="A0A836KG20"/>
    <dbReference type="GeneID" id="92359932"/>
    <dbReference type="KEGG" id="loi:92359932"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160107">
        <property type="term" value="F:tRNA (adenine(58)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000422">
        <property type="entry name" value="tRNA (adenine(58)-N(1))-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049470">
        <property type="entry name" value="TRM61_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133:SF2">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE CATALYTIC SUBUNIT TRMT61A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08704">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017269">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 8" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 C-terminal" evidence="10">
        <location>
            <begin position="71"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 C-terminal" evidence="10">
        <location>
            <begin position="188"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="119"/>
            <end position="122"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR017269-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5474829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="335" mass="36206" checksum="0A9BA91A9BAF5233" modified="2021-09-29" version="1">MLAPRGAIAKDGDVVLVVHGHRSITPLVLQHGAVLHCKAGRFDHDDIIGHPLGRCVKGRSNQKGDPREPSVLILQNSADMWTQAVPHRTQIIYDTDIAVILLNLRLGPGKKVVEAGTGSGSLTHSLAKTVAPSGCVYTCDFHRQRCLEARAEFRRNGLDAHLVCSQWRDVCTTNTGTADVVDGVDADVAAMDAPRTGFGVPAASVDAIFLDVPAPWAAIENVCHVLKEGGMLCTFSPCMEQTQRTAEALRAAPHHFVDIRTVEALTKFFEPVFKRARDALDHDCIKFRASLVSKGHSAYLTFARRRLAKLEQLEGEKALQAVGAVENGGEGATRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KGM7</accession>
    <name>A0A836KGM7_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_03454</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061394.1">
        <property type="nucleotide sequence ID" value="XM_067205457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KGM7"/>
    <dbReference type="SMR" id="A0A836KGM7"/>
    <dbReference type="GeneID" id="92359391"/>
    <dbReference type="KEGG" id="loi:92359391"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016643">
        <property type="entry name" value="26S_Psome_Rpn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002015">
        <property type="entry name" value="Proteasome/cyclosome_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041433">
        <property type="entry name" value="RPN1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040892">
        <property type="entry name" value="RPN1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01851">
        <property type="entry name" value="PC_rep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18051">
        <property type="entry name" value="RPN1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17781">
        <property type="entry name" value="RPN1_RPN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015965">
        <property type="entry name" value="26S_Psome_Rpn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="RPN1 N-terminal" evidence="5">
        <location>
            <begin position="47"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit RPN1 C-terminal" evidence="6">
        <location>
            <begin position="855"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="603"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="603"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="627"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5473391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="909" mass="99241" checksum="F3D847F3CF57E71B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KGY9</accession>
    <name>A0A836KGY9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Guanine nucleotide-binding protein subunit beta-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060626.1">
        <property type="nucleotide sequence ID" value="XM_067205074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KGY9"/>
    <dbReference type="SMR" id="A0A836KGY9"/>
    <dbReference type="GeneID" id="92359008"/>
    <dbReference type="KEGG" id="loi:92359008"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051150">
        <property type="entry name" value="SWT21/TCAB1_mRNA_Telomere"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13211">
        <property type="entry name" value="TELOMERASE CAJAL BODY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13211:SF0">
        <property type="entry name" value="TELOMERASE CAJAL BODY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5470360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="423" mass="46086" checksum="FE5672956D8B9899" modified="2021-09-29" version="1">MPSFRKEEAHVRRLYSAPDNTSELLATCDKAYVPSLTYTPSTNSPVVVAEDAATAPRVKLPFPAIDIAWCPFKKGTANAAYATTCRSQPIQIWDLADAELRASYAATNDSDYHVHAHALCWFSAPTHQHWIAGGYGGFEDVTQVRVFDIMAEGSQPIWTYRNKHWKGIVSSMHDCQWQGTTSLLAVGNFNTPSVYLIDCRKPCLAAELHGLQQGVQIIRSGMQGVDPYCVYAGGNQGDSRIACWDVRKPCAPLFTVTRAAHTNQVFQFDLLPLSPAAAADGGAVDCSRGLVSTCSTGGVLLYRWRPGGIPTDGAEAHIARSVGPTSGLAVVGPDTVIVSTGSRTYGSSSRAHEERVTSLNHCSPRRDNTYCETDELQNFPVHKRQRSPMQDDSDEELSLSELQPRSSTEATNIAAVSLTQRHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KHQ5</accession>
    <name>A0A836KHQ5_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_03794</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061727.1">
        <property type="nucleotide sequence ID" value="XM_067205790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KHQ5"/>
    <dbReference type="GeneID" id="92359724"/>
    <dbReference type="KEGG" id="loi:92359724"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5474621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="74" mass="7832" checksum="4A41BC68EF61827D" modified="2021-09-29" version="1">MPALATASSSSSESGTPRMAAGTLCMKCHQSAIEFETNSCHHPCFCRPCAMKCASGGKCKTCGQFYAGLTHVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KJF7</accession>
    <name>A0A836KJF7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_00989</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059705.1">
        <property type="nucleotide sequence ID" value="XM_067203055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KJF7"/>
    <dbReference type="SMR" id="A0A836KJF7"/>
    <dbReference type="GeneID" id="92356989"/>
    <dbReference type="KEGG" id="loi:92356989"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09252">
        <property type="entry name" value="AP-3_Mu3_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14837">
        <property type="entry name" value="AP3_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000002">
        <property type="entry name" value="AP-2 complex subunit mu, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00991">
        <property type="entry name" value="CLAT_ADAPTOR_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="6">
        <location>
            <begin position="191"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5467903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="468" mass="51471" checksum="E451B364A9DF79F6" modified="2021-09-29" version="1">MLSCIFLLNEHGEVMVELQFSERIPRSTLEGFWSTFMAPWKGASEAPAAIVAYGGTVFSHIHRNNVFIVGTHPLDNTALVVIEQLCLVARVLTTYLSEVTENTIRENFSTVYQLLQEMFDYGYPLTTELYALDELVPRPTLENRVRTILDTPFVNKVMPVGNRAALGVGSRQVSNFYVGVPWRDPETRHSTNEVLFDVVESLDYVLDSEGRCVRAAVQGSIEVNCRLSGMPEMALRLRDVDAVVDDVAFHRCVRLDRYEHDRTLCFIPPDGKFTLMKYTCRPSMPMPLPPFYVTPQVSFNATGGRFHCMAGIRGGGADFSSVAEKCKEVQRLSVRLLLPPNTSSLTVTNCSSGTTAFDRSKGTLTWSVGSLTQSATPSVGGEFLIEPDGGGNSAERGRGTAPSPKPVRVAAHGAGVGNATMATVSFQLPNQIMSSLRVDSVQIMNEIGKPYKGLKYLTQSGKYFIRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KJG8</accession>
    <name>A0A836KJG8_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_02251</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061321.1">
        <property type="nucleotide sequence ID" value="XM_067204284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KJG8"/>
    <dbReference type="GeneID" id="92358218"/>
    <dbReference type="KEGG" id="loi:92358218"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5472925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="95" mass="11492" checksum="532BADA95519946E" modified="2021-09-29" version="1">MLRRSSRCWMKYANLELTTRGEFPHGMKEPGFVKKLDKNIPWYFSTYRCMYHWPLAGEGWSDLNEADKHHDLHMYYTLAWWKLGEGIFDADDEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KKQ6</accession>
    <name>A0A836KKQ6_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_01845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000022">
        <property type="protein sequence ID" value="KAG5479254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063347.1">
        <property type="nucleotide sequence ID" value="XM_067203888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KKQ6"/>
    <dbReference type="GeneID" id="92357822"/>
    <dbReference type="KEGG" id="loi:92357822"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5479254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="568" mass="59057" checksum="0421A3A1E70F527C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KLG8</accession>
    <name>A0A836KLG8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">T-complex protein 1 subunit epsilon</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">CCT-epsilon</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LSCM4_02772</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060344.1">
        <property type="nucleotide sequence ID" value="XM_067204792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KLG8"/>
    <dbReference type="SMR" id="A0A836KLG8"/>
    <dbReference type="GeneID" id="92358726"/>
    <dbReference type="KEGG" id="loi:92358726"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03339">
        <property type="entry name" value="TCP1_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000003">
        <property type="entry name" value="T-complex protein 1 subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012718">
        <property type="entry name" value="Chap_CCT_epsi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02343">
        <property type="entry name" value="chap_CCT_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 12" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0346">Stress response</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG5470078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="538" mass="59232" checksum="4B344FDDD2D36F9B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KLK1</accession>
    <name>A0A836KLK1_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060449.1">
        <property type="nucleotide sequence ID" value="XM_067204897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KLK1"/>
    <dbReference type="GeneID" id="92358831"/>
    <dbReference type="KEGG" id="loi:92358831"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5470183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="441" mass="45732" checksum="1076D7BE232B6F2F" modified="2021-09-29" version="1">MPLPLSGFTPDSPLITAEPQRNTHARVRTSITKGPCWSLASLNDRLTPDAVCANDSASCSRGESLAVCMRSPTQREVVPVVTGASHLTLRESLSLLSDLSFRPEVDGAAATPLVLSSEEELENVSAMAAVLSQPQSPWLTVSSSGESHPTLHRECVTSAAAKTLQGLGVPAGLSTFSPTSAMSAASSPPDRLHGAGLIRLNSAPALRGMAKGRTVQVLGSPPEVEVDRPHPAALKIAALTLSGPIAHHRDDPSTTQLQDEASLTSSSGLCTSCLRAPTSIPGAVFESVAAVAFAGVGAHEFSLCSPSSSMLTFVDHELDITTDPAVLHLGDSLLGVSEAGSLLDSEGGLRPSGTRHYLLAGTHSPLSSGPVMSFASKSNPQHRCRPAVVTSVAQSAQFTPEYAAAVQAAAAYGRSLRQILARRSDDADDALRDSAEMSSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KMG0</accession>
    <name>A0A836KMG0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Gfo/Idh/MocA-like oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_04695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000023">
        <property type="protein sequence ID" value="KAG5478462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063123.1">
        <property type="nucleotide sequence ID" value="XM_067206676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KMG0"/>
    <dbReference type="SMR" id="A0A836KMG0"/>
    <dbReference type="GeneID" id="92360610"/>
    <dbReference type="KEGG" id="loi:92360610"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46368">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46368:SF4">
        <property type="entry name" value="OS10G0403700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="6"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5478462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="192" mass="21164" checksum="6FBE17EF05D90E59" modified="2021-09-29" version="1">MSSPALRVGLLGAANIAWRAWAGVHANGMTVTRVGCRDADRGRDFVKRVCDTLKIEEAAMPTVCSYEELVSAADVDVVYMATPVTAHDHWVKECIQYESHVVGEKPSAVDAEVLRSWIETLDQQNLVYMDGTMLSHGKRVREVCAAVKRMGGPVKHIFANFTLGGDEAFLQNNIRTHPDLEPHGVLGDLGWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KMR1</accession>
    <name>A0A836KMR1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CN hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_05235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062488.1">
        <property type="nucleotide sequence ID" value="XM_067207185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KMR1"/>
    <dbReference type="SMR" id="A0A836KMR1"/>
    <dbReference type="GeneID" id="92361119"/>
    <dbReference type="KEGG" id="loi:92361119"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050152">
        <property type="term" value="F:omega-amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006528">
        <property type="term" value="P:asparagine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07572">
        <property type="entry name" value="nit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000033">
        <property type="entry name" value="Putative nitrilase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045254">
        <property type="entry name" value="Nit1/2_C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088">
        <property type="entry name" value="NITRILASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088:SF30">
        <property type="entry name" value="OMEGA-AMIDASE NIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="5"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5476255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="279" mass="30908" checksum="5B41D767D3E83F5A" modified="2021-09-29" version="1">MNSVLPVTLCQMAVTREKAANISKAVRMITEAAKRGSKLAVLPECFNCPYGTRYFDECSEALAPGNETFDAMSQCAKDNSIWVVAGSIPEKSGDGKLFNSSMTFGPDGKLKHIHRKVHLFRIDTEAVRFNEGEVLSAGNDATAISLDEHTKFGVAICFDIRYPLLAWKYAEQGTSFIVYPGAFNMVTGPAHWELTARARAVDNQQYVLMCSPARDTSAEYVAWGHSMVVDPFGTILGELDEKEGSLDVKVDFRAVSEARDRIPILKGVRDDLYTLHWKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KMR5</accession>
    <name>A0A836KMR5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MATH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_05250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
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    </evidence>
    <sequence length="640" mass="71562" checksum="C0A152A88674CB1F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
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            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
            <dbReference type="EMBL" id="KAG5479857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="367" mass="40096" checksum="CE65AFA516E4B3E4" modified="2021-09-29" version="1">MSLRYTREGMRCVRVLLHGKLLYPVGTGRLALGTELLPLLPSNDIFYDPPKLRYRLDEDGYLYFKNIVPRDVVNAGLDDLANQMRDCGCTLDEDRTRQAELNGFAMGVPYPTTSGDELPPPNIHQTDTIRNAVCGTSVMATVRQVFGGAVKVATLQTLHLGAPGEPFGFRMPSVLMNRGTKLALVALVPLHDTPLHMGTPLLVRSSNSHTTYARLRKTYGQWEVEGDSIRGDGCYTENPAELSPLGKLPGKDEATGASIIVDANPFASSALEAGDLLLTTVYTMQSFLTNQTNCWRLMAEAVWCMEGDDVGLDPRYMGSDAPGLAAWIERRDDPTVYPKSLLEAKKEWGLVPDLATAATDTTKASSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479872.1"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5479872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="342" mass="37072" checksum="01748E2C15BF19DE" modified="2021-09-29" version="1">MFTKRLSAPAMRHALNVPSLRGMTANPAAACNPLCWSRRYCSSVSVHAGSSARPASVSAVNVEQFTLNEEVVKQDLANMAKWNALSEAIGTARAAGDHTKLLGHVQAGLQMLQEMGATNAPIQCESLLCMEASQAHYKMGQYDEALRCAEQARESLLRDCKPELQDRAQIAEIEVFMGFILCKQRDYGAAVEAQELLQKVLRWVDVDAKSAMPMQAVAAVNLRRSVLTGLGLSTTVQATALASKGETSEAKELYAKGLDTLIEALNLHIDENDFELVKVTLKEILTSFEGLGDVSQAVTTCRKYISWCSRHNDASGVADGEAMLMALCARHSIENPLDAAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KPN4</accession>
    <name>A0A836KPN4_9TRYP</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name evidence="2" type="ORF">LSCM4_07245</name>
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    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000015">
        <property type="protein sequence ID" value="KAG5483034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067209147.1"/>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="140"/>
            <end position="159"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5483034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="208" mass="23504" checksum="274DAF52F9900F46" modified="2021-09-29" version="1">MVLFCRDKRPSSPKGASHSLVNPHQNTSWWCIRFSCVRNATTSHTAIFFTLAKVFPSFKMEKLVRASMNYTIFGFASGFYWRELTKHLKYVSNGTSQLRVMHTHCFALGSFFFLFVLLLEKSFSLTKQKNYKKFYVTYNIGLGITLLMMLVHGTLTVVGKDQNSRLISWTAGLGHIFMSVGFGYFYNVLLAAVRASGGKADKKATVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KPN9</accession>
    <name>A0A836KPN9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Membrane transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_07263</name>
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    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
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        <lineage>
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            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000015">
        <property type="protein sequence ID" value="KAG5483049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064545.1">
        <property type="nucleotide sequence ID" value="XM_067209162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KPN9"/>
    <dbReference type="GeneID" id="92363096"/>
    <dbReference type="KEGG" id="loi:92363096"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23525:SF1">
        <property type="entry name" value="NODULIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRANSPORTER, PUTATIVE-RELATED"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <end position="79"/>
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        <location>
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            <end position="111"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        <location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="460"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="492"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="521"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="586"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5483049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="632" mass="67049" checksum="A45DB6070EBFF7E7" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KQZ3</accession>
    <name>A0A836KQZ3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amastin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000016">
        <property type="protein sequence ID" value="KAG5482332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064338.1">
        <property type="nucleotide sequence ID" value="XM_067207524.1"/>
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    <dbReference type="GeneID" id="92361458"/>
    <dbReference type="KEGG" id="loi:92361458"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40741:SF1">
        <property type="entry name" value="AMASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="109"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="140"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5482332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="24411" checksum="ED5E511258339327" modified="2021-09-29" version="1">MLCYRVTLLICTIIFTACMTCSILFPIFRKVTNDPEKMRRTVYYWYMEMSTVRTSHGSSETLTRRYYTRDLPCQQAKIFYVASSAISVAAAGIGGVACLILACWTTAGYSFIVRFVGFLATFLSMACAGAVVGLSTYIFTQDFCAHDAAAIEYQKAPKKDGYAMVEGFGLACAAAGGFLIIAVIQLIGLCRGCQAQAASSERVRHPKNAFDGGCSDVDSSISRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KRN6</accession>
    <name>A0A836KRN6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NADH-cytochrome b5 reductase</fullName>
            <ecNumber evidence="7">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_07938</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">LSCM4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="7"/>
    <dbReference type="EMBL" id="JAFHLR010000013">
        <property type="protein sequence ID" value="KAG5484371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064864.1">
        <property type="nucleotide sequence ID" value="XM_067209814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KRN6"/>
    <dbReference type="SMR" id="A0A836KRN6"/>
    <dbReference type="GeneID" id="92363748"/>
    <dbReference type="KEGG" id="loi:92363748"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000182">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000070">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF185">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0274">FAD</keyword>
    <keyword evidence="2 6 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 7" id="KW-0520">NAD</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="8">
        <location>
            <begin position="31"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5484371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="308" mass="34849" checksum="063B68397E20B043" modified="2021-09-29" version="1">MICILVIIALNMAAFFAFMFARMKKVAMDPTMFKHFKLIRRTEVSHDTFIFRFALENEKQTLGLPIGQHIVLRADCTTGGKTETVTHSYTPISSDDEKGYVDFMIKVYFAGVHPNFPNGGRMSQHLHKMQLGDTIEMRGPQGKFTYLGHGTSRIQKSGQGFVTEKVDAYAAIAGGTGITPILQIIHAIKKNKEDRTKVFLVYGNQTERDILLRKELDEAAANDDRFHVWYTVDRDVTPAWKYDVGYVREEMFRKHLPVPDMLGNDSVPQNAGITKVMALMCGPPPMVQMAIKPNLERIGYTAENMFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="2">Rnh202 triple barrel domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="3" type="ORF">LSCM4_07670</name>
    </gene>
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        <name type="scientific">Leishmania orientalis</name>
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        <lineage>
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            <taxon>Euglenozoa</taxon>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000012">
        <property type="protein sequence ID" value="KAG5484897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065009.1">
        <property type="nucleotide sequence ID" value="XM_067209549.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="loi:92363483"/>
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    </dbReference>
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        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RNase_H2_suB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041195">
        <property type="entry name" value="Rnh202_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13383">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT B"/>
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    </dbReference>
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        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ydr279_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rnh202 triple barrel" evidence="2">
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            <begin position="235"/>
            <end position="323"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
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        <location>
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            <end position="143"/>
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        <location>
            <begin position="622"/>
            <end position="678"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="438"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF17745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5484897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="678" mass="71054" checksum="2D52596F01612E84" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KUV4</accession>
    <name>A0A836KUV4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">COPI associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_07562</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
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            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000004">
        <property type="protein sequence ID" value="KAG5487881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067209446.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="92363380"/>
    <dbReference type="KEGG" id="loi:92363380"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28128:SF1">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP15"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="COPI_assoc"/>
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    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
    </feature>
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        <location>
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            <end position="141"/>
        </location>
    </feature>
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        <location>
            <begin position="170"/>
            <end position="199"/>
        </location>
    </feature>
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            <begin position="213"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5487881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="29696" checksum="2D8F975B4EE77B8D" modified="2021-09-29" version="1">MDPNRRVESRAPESQSCWQRNWPRAFLFMSAAVVVLSFVGIILSLAKIVLSPSVVLLDMYCLLFSLLGLSAELRQFSVLRRVVYVWMKFFYFLVYYRARGIFYIFFGILLLGNGVAEIMGGIVAIALGAVMLLVGVVVGLPEFEDPAEAKRVQEEFQRYYGGGSPSAADGAPSAAAGAPSATTAAPASPAAKSGAQADPPAVSASANLYREYNFGDSPTREESRTFSNPGSGANPYEDRSSFQGLEANMFAADSASAIKLPMQEAGLTRGEGQSALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KWE7</accession>
    <name>A0A836KWE7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PUM-HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_05981</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000011">
        <property type="protein sequence ID" value="KAG5485345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065082.1">
        <property type="nucleotide sequence ID" value="XM_067207908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KWE7"/>
    <dbReference type="SMR" id="A0A836KWE7"/>
    <dbReference type="GeneID" id="92361842"/>
    <dbReference type="KEGG" id="loi:92361842"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF122">
        <property type="entry name" value="RNA-BINDING PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="493"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="PUM-HD" evidence="4">
        <location>
            <begin position="511"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="97"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Bates M.D."/>
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                <person name="Bates M.D."/>
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        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
            <dbReference type="EMBL" id="KAG5470037.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="300" mass="32845" checksum="E8D56473A9B945CD" modified="2021-09-29" version="1">MSVFGISSYFLWTQKGQTVLPLVRGSGFLIAFQQLNTFYSYHVMSAAHVTCPVKHRKLYGDTIGLKAIGERHISTRLLIPDEATRKVRSSFELEFRQHYMPNTDVASLRLIKEKEFKEAMQLPLDSSTGATSPLQVIEPDLDYIDEGDELVLCGVHTEEERANPNDDGLLLNPLRLAATCKAAFLSLDYGTVLLASIDGPAEEASRSGGASSASCPVAVPPLPLSMCGGPVLRRSSGKCVGVIATRVLKSAPPRDPHSASLYEDPWLDISQHVALHAHGHLDVAFVPIGEFYDPLRRCEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FZK7</accession>
    <name>A0A836FZK7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Acid phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_00262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058452.1">
        <property type="nucleotide sequence ID" value="XM_067202351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836FZK7"/>
    <dbReference type="SMR" id="A0A836FZK7"/>
    <dbReference type="GeneID" id="92356285"/>
    <dbReference type="KEGG" id="loi:92356285"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF137">
        <property type="entry name" value="PHOSPHATASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5464821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="473" mass="53814" checksum="B1CA82BCB0FCE2CD" modified="2021-09-29" version="1">MAAMTTPVRGALAWRSAFVAFMMVLVVAMNELTLVSAIALGSAPVDEQSSESQPVYPAHPRADINWTQASVKSNISKTERKEILKSKLVLTKMVVLNRHGHRSPNAPFWKMCPNEIKSKKRYDVDAADLSGLGMEEEYNFGRYLRKAYASFIGEKFNRTLHYFRAVGEPRILQSAVAVAQGIFPDGFGPGGYLPSRPQFVPIFSDMDTHEYLLDDVPCFRRAENDSHRWIDTHYAEFIGDPSTGRVLRMMKEVCGEYKGKAEDYAYIKTVADGLTFNNDIGLKVAKGKLTPEMLFSIRNVSLQLLMQRLYNTDEQRTYMAADLPRNILQALNHTHAKGTPVQMSDVTDTLHESNFYFMHREALYAFAQFFGFQYNIAGLPPGEVPVATSLIIEKLVPRREQHFNSASHIYVRMTLWTPYNGIYTVPIPTCRIPELCKLKELQHIYDTRVARTGTWEQLCDYTPQEIDHTTDIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G228</accession>
    <name>A0A836G228_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_01546</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PNO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059286.1">
        <property type="nucleotide sequence ID" value="XM_067203595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G228"/>
    <dbReference type="SMR" id="A0A836G228"/>
    <dbReference type="GeneID" id="92357529"/>
    <dbReference type="KEGG" id="loi:92357529"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22391">
        <property type="entry name" value="KH-I_PNO1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22392">
        <property type="entry name" value="KH-I_PNO1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000082">
        <property type="entry name" value="RNA-binding protein PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055212">
        <property type="entry name" value="KH-I_PNO1_first"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055211">
        <property type="entry name" value="KH_PNO1_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826">
        <property type="entry name" value="RIBONUCLEASE Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF13">
        <property type="entry name" value="RNA-BINDING PROTEIN PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22891">
        <property type="entry name" value="KH_PNO1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="5">
        <location>
            <begin position="134"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5466396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="221" mass="24562" checksum="50AF61A194F718A5" modified="2021-09-29" version="1">MSSDAVAATSSMTGDETRAPVAKTAAVSFVRETRSIKIPHHRFPPLKKVWMEVYTPIVEQCKLEIRMNLKTRCVDLRTSPSTSTVEGDQSVAASKVMLQKAEDFVKAVIAGFDVRDAVALLRMDDVYIEGFEIKDVRANLQGDNLSRCIGRISGSHGKTKYTIENVTRTRIVLADTKIWIMGTTQNIRVARDAICDLIRGSPAAKVYTRIRAVMNRVNNAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G3Y4</accession>
    <name>A0A836G3Y4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_03846</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061778.1">
        <property type="nucleotide sequence ID" value="XM_067205841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G3Y4"/>
    <dbReference type="GeneID" id="92359775"/>
    <dbReference type="KEGG" id="loi:92359775"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47936:SF1">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN GUN1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47936">
        <property type="entry name" value="PPR_LONG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="186"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="186"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5474672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="628" mass="70618" checksum="C2E5E0ACFE12FD96" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G4N2</accession>
    <name>A0A836G4N2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_00749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058925.1">
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5465294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="291" mass="33511" checksum="D95C57509B065204" modified="2021-09-29" version="1">MFQSGSSARLKLEPAAAGSYQPVQVPREKYDKIVQGRNRFFLATIGGVALFMGMSALPQFFMYRCVRRVYRNYCRGKVLDLSPKLYDEKDVALYEMSKAVCVDFLIEEKVVDDGHYRSDEALPEEEQEKRRRSMTLDFMTRNDHNWVGSTVNFATVLRADTQLPGFTKYDCVLLRDELLNQNETKARDLFDSAAQYVKEDGLFLVMDVGKSTSPQLIKLARWFNKATNSSMCLTHDYHSWIRESMLYDVKEEQRCLFGFYYALVLQLRKAAAPMTGVDGSQLTSHRKGVSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G6F8</accession>
    <name>A0A836G6F8_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062330.1">
        <property type="nucleotide sequence ID" value="XM_067207027.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="92360961"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5476097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1085" mass="115395" checksum="2714BB51C4090D99" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="12">Mitochondrial carrier protein</fullName>
        </recommendedName>
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        <name evidence="10" type="ORF">LSCM4_02669</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5469981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060247.1">
        <property type="nucleotide sequence ID" value="XM_067204695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G886"/>
    <dbReference type="SMR" id="A0A836G886"/>
    <dbReference type="GeneID" id="92358629"/>
    <dbReference type="KEGG" id="loi:92358629"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000246">
        <property type="entry name" value="Putative mitochondrial carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="95"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="208"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5469981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="311" mass="33389" checksum="99E03D201ECE2167" modified="2021-09-29" version="1">MDSLLAGACAGLFVDLSLYPIDTVKTRVQSKEGFSASGGFKNVYKGLSAMAVGSVPGGAAFFFGYDTAKRSFLTFTAASGAASSLDGAAAAMSPRVMACQAAAAMCGECFACCIRVPVEMVKQQMQAGHHATIIAALRNVTNNTTKPVFAPVDAAAATPQQRIRLSGVHHLFRGMPIMLMRELPFSVIQMSLYESLKAKMCTSQDHSYASFSLPLCGAFSGGCAAFLTTPLDVLKTRIMLFRRAPGQDKVSVRYVLDDLVREPARPGDRFGYAQRFFRGASTRVLWISLGGSIFFGTYEVVKTGFQNVYPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G8P6</accession>
    <name>A0A836G8P6_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060487.1">
        <property type="nucleotide sequence ID" value="XM_067204935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G8P6"/>
    <dbReference type="SMR" id="A0A836G8P6"/>
    <dbReference type="GeneID" id="92358869"/>
    <dbReference type="KEGG" id="loi:92358869"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="445"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5470221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="462" mass="48463" checksum="809C0CADDEC9A1C1" modified="2021-09-29" version="1">MEPSTAPDSISRTLDSAEELYGLVCALQKEQQLTQVELRAVQRRTDALQQELHRQQTTVSDEQARQEELTENLAQGYAERRLAEAHARGAARASDDAARELRLERRAFVRKCHCYALSLENAPTDAGLSDLPLALSTYTSLSSAADESCSGTVSAETVGAHRVASLMSPAAVHRLLLLLKTKLTRCMEVGATTAPGPLREPLQVTPITEGTSNEQPLGRITPAELCAAATVGPAVVASVLAGICPHRPPSPPIATGSVCDAADGQSSSREKKRIGFAPVSCFERVTAVPAANVNRSTRLIGPTGGSTLACSSAAAAPPCANMEADSDSIPPPTYLKNGPLPRTQRFGGNFTVRVASRSAMLLAEAAALGAKRQRASEAARVTHSSPPKAARVDGVEGGLACSAPHNASATPVLAPACTKDRGCIVVPADLLLPLSAEARRNASSGPGRRTVWTWTRGTPPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GDA3</accession>
    <name>A0A836GDA3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_02186</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061257.1">
        <property type="nucleotide sequence ID" value="XM_067204220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GDA3"/>
    <dbReference type="SMR" id="A0A836GDA3"/>
    <dbReference type="GeneID" id="92358154"/>
    <dbReference type="KEGG" id="loi:92358154"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="6">
        <location>
            <begin position="29"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5472861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="339" mass="37935" checksum="54D04E576EAAC46F" modified="2021-09-29" version="1">MRTLTPSLLEFFKGMLTTSLLFSLLLNITSSIGVIIVNKRLVFMEAHFEFSTVLTIIHFVVTFLGCVFFAYGVQLFKPKKLSIRRVFPISCVFCGYVVFNNLSLLANSVSVYQVLKILCTPIILCIEWVHYGKREKLSTLLSLLPVCVGVAITCFSDTDVNWIGTMWALLAIITNSLYTIWGKTKQVEMGVQPMQLLMYQAPMSAVMLLLAVLPLDNAEKLAAYDVTFTTVWTVLLSCIFAFGVNFSFFCFVGKTSPLTMNVVGYLKTLLVFVLDFLFVSATIPPQKMIGISLTLLGLAGYSYSKIESPENLTPRTRWNPHCDTFNKQHGIVETNVISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GDS7</accession>
    <name>A0A836GDS7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Tubulin-specific chaperone A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_02984</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Tubulin-folding protein; involved in the early step of the tubulin folding pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
            <location evidence="2 9">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the TBCA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060555.1">
        <property type="nucleotide sequence ID" value="XM_067205003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GDS7"/>
    <dbReference type="SMR" id="A0A836GDS7"/>
    <dbReference type="GeneID" id="92358937"/>
    <dbReference type="KEGG" id="loi:92358937"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.90:FF:000010">
        <property type="entry name" value="Tubulin-specific chaperone A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004226">
        <property type="entry name" value="TBCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036126">
        <property type="entry name" value="TBCA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21500">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21500:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02970">
        <property type="entry name" value="TBCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46988">
        <property type="entry name" value="Tubulin chaperone cofactor A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6 9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="30"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5470289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="125" mass="13971" checksum="666A9825B7EF4AE5" modified="2021-09-29" version="1">MSESSEPTNRFAGNVRQAEAPNEKTLRIKVSALKRNIKDLEFAKREVEQELQRLDSLRQIAPDRVPQQTKVIDEAKMMVPHSVNRIMAAVKDLSEYLEKEGSTVCNDELLDSARAAMADGQASVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GE72</accession>
    <name>A0A836GE72_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="1">4.3.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_06123</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.9" evidence="1"/>
    <dbReference type="EMBL" id="JAFHLR010000020">
        <property type="protein sequence ID" value="KAG5480357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063688.1">
        <property type="nucleotide sequence ID" value="XM_067208048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GE72"/>
    <dbReference type="GeneID" id="92361982"/>
    <dbReference type="KEGG" id="loi:92361982"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003839">
        <property type="term" value="F:gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017939">
        <property type="entry name" value="G-Glutamylcylcotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935:SF0">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13772">
        <property type="entry name" value="AIG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
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</entry>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
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            <dbReference type="PubMed" id="34489462"/>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GGX8</accession>
    <name>A0A836GGX8_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000017">
        <property type="protein sequence ID" value="KAG5481842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064202.1">
        <property type="nucleotide sequence ID" value="XM_067208828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GGX8"/>
    <dbReference type="GeneID" id="92362762"/>
    <dbReference type="KEGG" id="loi:92362762"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5481842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="443" mass="48900" checksum="6111A226CD0098F3" modified="2021-09-29" version="1">MLARTSVHRAGLLSTLIANGALCAAHFTSMQTPAGALILSGCIFRCLAMPFTIYGDQCLHRVACALPELQDAYKEYLDIVEHPRAIVWEKRVAAQKLKNDRDRIFRSFRTNNVKMTAPYVVSSALSLYCLCVPAQQIGGLFQGVGMAVVSPLAVSCMEGGQLSLASTASIAPAALFTVDPTLALAAGLTCFNVLRHLNQRVGFNDRLDGWIKNTKQVVCLSLGLVAAGSLLADPLTYVLALPALHFFPPYLAPVWLGMSATTAAKTVLVNGTAPGQAMFRLPSYPPQHGTYGGESTAAGHEYRLAFTGVDWEETRSVWQAQKRILDYECDVRLHRFLKRIGFLSDIDELEYEVDKLKRKRAVARERHRTRTEPDKGAPTMTQAAMRRHVMHENDGEASQEADVHSSASSLEKALEQVERVQLEELRGRQARRAAREAAWKQRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GIM6</accession>
    <name>A0A836GIM6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">S-adenosylmethionine decarboxylase proenzyme-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_02239</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amine and polyamine biosynthesis; S-adenosylmethioninamine biosynthesis; S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic AdoMetDC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061310.1">
        <property type="nucleotide sequence ID" value="XM_067204273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GIM6"/>
    <dbReference type="SMR" id="A0A836GIM6"/>
    <dbReference type="GeneID" id="92358207"/>
    <dbReference type="KEGG" id="loi:92358207"/>
    <dbReference type="UniPathway" id="UPA00331">
        <property type="reaction ID" value="UER00451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004014">
        <property type="term" value="F:adenosylmethionine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006597">
        <property type="term" value="P:spermine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.90.10">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048283">
        <property type="entry name" value="AdoMetDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016067">
        <property type="entry name" value="S-AdoMet_deCO2ase_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11570:SF2">
        <property type="entry name" value="DECARBOXYLASE PROENZYME-LIKE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11570">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01536">
        <property type="entry name" value="SAM_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56276">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0745">Spermidine biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5472914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="35126" checksum="E5A99337955CD5DC" modified="2021-09-29" version="1">MPTNAWASPRDVFPESVRALMSLWGGFSNPTSYSDSGLEKRLELDFATAVNVQTFTVAELEYVLAAAGQELLHHSSAEGLLTLEMTQSIVIVAPLKLVVTSASEVMLHQVVTPAIAFLTSKGIRVEWASYLRKNTTSPWCAESETSDIMAQEYAELKAAFPTGKSFLTGPVDGHHYFNYVYDDVERGAERKEQDVQVNVFLYDVAAGLEEVHKTTQRFHALPSGEYEVTRTFAGVPCVSFETNAKAAVATPTRVQELVDTFQPAHFTIVALQDKDADGSELRRNFDAFNAYTLQNRTVNFFGEGYAFHQLLFARSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GJ75</accession>
    <name>A0A836GJ75_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_01606</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059345.1">
        <property type="nucleotide sequence ID" value="XM_067203654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GJ75"/>
    <dbReference type="GeneID" id="92357588"/>
    <dbReference type="KEGG" id="loi:92357588"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5466455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="115" mass="12541" checksum="3DE9B35CBA3118C2" modified="2021-09-29" version="1">MAMPTPQAAATRVVESTEADMALRFLNHCLSNAVQVHYLVANSLEGGDWQTSKLLEAEAQAYMRALLAAYTASSTFRRQLVSGDSLYYLQCLTDETTRADFVRVAAAPSFPFASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GJQ5</accession>
    <name>A0A836GJQ5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">NADH dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_00575</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058754.1">
        <property type="nucleotide sequence ID" value="XM_067202653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GJQ5"/>
    <dbReference type="SMR" id="A0A836GJQ5"/>
    <dbReference type="GeneID" id="92356587"/>
    <dbReference type="KEGG" id="loi:92356587"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054585">
        <property type="entry name" value="NDH2-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706:SF13">
        <property type="entry name" value="NADH DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22366">
        <property type="entry name" value="NDH2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="7">
        <location>
            <begin position="13"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="External alternative NADH-ubiquinone oxidoreductase-like C-terminal" evidence="8">
        <location>
            <begin position="370"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="465"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="507"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5465123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="527" mass="57599" checksum="2AB691D1E1792C53" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GKM8</accession>
    <name>A0A836GKM8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vacuolar iron transporter 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_04096</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CCC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062022.1">
        <property type="nucleotide sequence ID" value="XM_067206085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GKM8"/>
    <dbReference type="SMR" id="A0A836GKM8"/>
    <dbReference type="GeneID" id="92360019"/>
    <dbReference type="KEGG" id="loi:92360019"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008217">
        <property type="entry name" value="Ccc1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31851">
        <property type="entry name" value="FE(2+)/MN(2+) TRANSPORTER PCL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01988">
        <property type="entry name" value="VIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5475514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="30943" checksum="F984A605DC88C4EC" modified="2021-09-29" version="1">MSELTALNVPATENTDYKSCDAARAAFRAGDVEASRREHMKPMHTESHNSSASEYVKSVVFGGLDGIMTTFAIISAAAGGGGNYATVLIFGFSNVIADGFSMGFGEYVSGEAERENAISERRREEWEVENSFDLEIDEMVQIYMARGLSFDDANTIVAIISKDPKMFVDFMMVEELGLLVDLDDVDGPKKQGAVMFASFALFGSVPLLAYLPGKGEGTDAVFFVSCLLTMASLVFLGSVKGYLVGVNMVRSALLMVLNGVISGLVSFLAGHLIEMALSKGVETATTVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GKS3</accession>
    <name>A0A836GKS3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_04171</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062097.1">
        <property type="nucleotide sequence ID" value="XM_067206160.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92360094"/>
    <dbReference type="KEGG" id="loi:92360094"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001592">
        <property type="entry name" value="ATP-binding cassette protein subfamily A, member 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000298">
        <property type="entry name" value="ATP-binding cassette sub-family A member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056264">
        <property type="entry name" value="R2_ABCA1-4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF262">
        <property type="entry name" value="TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23321">
        <property type="entry name" value="R1_ABCA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="484"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="535"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="569"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="597"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="627"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="665"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1120"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1279"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1324"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1362"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1396"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1467"/>
            <end position="1489"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="750"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1537"/>
            <end position="1767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5475589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1872" mass="205684" checksum="B1845AC25E958855" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GKW8</accession>
    <name>A0A836GKW8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_04247</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062172.1">
        <property type="nucleotide sequence ID" value="XM_067206235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GKW8"/>
    <dbReference type="SMR" id="A0A836GKW8"/>
    <dbReference type="GeneID" id="92360169"/>
    <dbReference type="KEGG" id="loi:92360169"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF91">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="535"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="565"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="607"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="642"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="678"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="775"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="206"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="47"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="178"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5475664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="805" mass="88132" checksum="5B1AF446034B8891" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GLU9</accession>
    <name>A0A836GLU9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Mannosyl-oligosaccharide glucosidase</fullName>
            <ecNumber evidence="11 12">3.2.1.106</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LSCM4_03981</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(4)-(alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + H2O = N(4)-(alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:55988"/>
            <dbReference type="Rhea" id="RHEA-COMP:12806"/>
            <dbReference type="Rhea" id="RHEA-COMP:14355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:59082"/>
            <dbReference type="ChEBI" id="CHEBI:132537"/>
            <dbReference type="EC" id="3.2.1.106"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the glycosyl hydrolase 63 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.106" evidence="11 12"/>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061910.1">
        <property type="nucleotide sequence ID" value="XM_067205973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GLU9"/>
    <dbReference type="SMR" id="A0A836GLU9"/>
    <dbReference type="GeneID" id="92359907"/>
    <dbReference type="KEGG" id="loi:92359907"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.110">
        <property type="entry name" value="Glycosyl hydrolase family 63, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031335">
        <property type="entry name" value="Glyco_hydro_63_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031631">
        <property type="entry name" value="Glyco_hydro_63N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038518">
        <property type="entry name" value="Glyco_hydro_63N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412:SF11">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03200">
        <property type="entry name" value="Glyco_hydro_63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16923">
        <property type="entry name" value="Glyco_hydro_63N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 N-terminal" evidence="14">
        <location>
            <begin position="114"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 C-terminal" evidence="13">
        <location>
            <begin position="428"/>
            <end position="938"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG5474804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="946" mass="107400" checksum="F9EAAFD6F8E5E334" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GNP5</accession>
    <name>A0A836GNP5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RecA family profile 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_05956</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000011">
        <property type="protein sequence ID" value="KAG5485322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065059.1">
        <property type="nucleotide sequence ID" value="XM_067207885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GNP5"/>
    <dbReference type="GeneID" id="92361819"/>
    <dbReference type="KEGG" id="loi:92361819"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF66">
        <property type="entry name" value="RE19845P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="4">
        <location>
            <begin position="204"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="385"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="401"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5485322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="578" mass="62216" checksum="0118EF9C517BA970" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GQ42</accession>
    <name>A0A836GQ42_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cilia- and flagella-associated protein 43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LSCM4_03433</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">LSCM4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CFAP43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060989.1">
        <property type="nucleotide sequence ID" value="XM_067205437.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92359371"/>
    <dbReference type="KEGG" id="loi:92359371"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056297">
        <property type="entry name" value="Beta-prop_Cfap43_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056296">
        <property type="entry name" value="Cfap43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14885:SF1">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14885">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 43-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25828">
        <property type="entry name" value="CC_Cfap43"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23185">
        <property type="entry name" value="CFAP43_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23184">
        <property type="entry name" value="WD40_CFAP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Cfap43 N-terminal" evidence="12">
        <location>
            <begin position="10"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Cfap43 second beta-propeller" evidence="11">
        <location>
            <begin position="322"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="998"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1182"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1431"/>
            <end position="1458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG5471872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1471" mass="162709" checksum="4C58FA4F1B3D0979" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GRW2</accession>
    <name>A0A836GRW2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zinc-finger protein, conserved</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_02156</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061228.1">
        <property type="nucleotide sequence ID" value="XM_067204191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GRW2"/>
    <dbReference type="GeneID" id="92358125"/>
    <dbReference type="KEGG" id="loi:92358125"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19756">
        <property type="entry name" value="Bbox2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
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        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF15227">
        <property type="entry name" value="zf-C3HC4_4"/>
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    </dbReference>
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        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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            <begin position="8"/>
            <end position="49"/>
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            <begin position="81"/>
            <end position="127"/>
        </location>
    </feature>
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            <begin position="133"/>
            <end position="177"/>
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    </feature>
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            <begin position="185"/>
            <end position="212"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50089"/>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="KAG5472832.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
    </protein>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="loi:92363902"/>
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        <property type="component" value="Chromosome 5"/>
    </dbReference>
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            <end position="298"/>
        </location>
    </feature>
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            <end position="464"/>
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    </feature>
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            <end position="735"/>
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            <end position="1082"/>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GTB1</accession>
    <name>A0A836GTB1_9TRYP</name>
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        <recommendedName>
            <fullName evidence="8">Cation efflux protein transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="9" type="ORF">LSCM4_06517</name>
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    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Kinetoplastea</taxon>
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            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG5480946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063947.1">
        <property type="nucleotide sequence ID" value="XM_067208435.1"/>
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    <dbReference type="KEGG" id="loi:92362369"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF15">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
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            <end position="109"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="151"/>
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    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="8">
        <location>
            <begin position="65"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="8">
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    </feature>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5480946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="616" mass="65760" checksum="069F500BAC00158A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GTC3</accession>
    <name>A0A836GTC3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Calcium uniporter protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">LSCM4_05751</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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            <text>Ca(2+)(in) = Ca(2+)(out)</text>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="molecule type" value="Genomic_DNA"/>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Bates M.D."/>
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    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5464755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="370" mass="38940" checksum="EB09537F9F09AF6B" modified="2021-09-29" version="1">MVLALCHSIPRNVEVQVALLLLFVTAVLQAAAIGLHRSYDAAGYFTLRGTGSSIAQAVGYVAAHPATYTRNGSVLVKLCDPSAAMLTRSCARFAEAYHAVNGLTVSSFVTCVVAFVAGVFVIVRVSRTTVSLLCRLTCAACVPAALQCAAVGVFFARVVPHARRDTARAGGWGEGELVFHRRAAADLMVAAAALVCGGLVLLVGRWMFVLCVRRQFESEPEHTKEGVRRLTAAHMVNDDWVRQRQILLSHARSVKVEMAVKRLHGGVDVLAASTSASHEPYNVPLKGSELSLRRTPSVAGGDSDDETLNLRTPAGCANAGRSAVAAEDGSASRRPGSTPPCAAPNEAAEEDATGQPFGDPAVREARQGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GVT5</accession>
    <name>A0A836GVT5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bacterial transferase hexapeptide (Six repeats)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_00540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058719.1">
        <property type="nucleotide sequence ID" value="XM_067202618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GVT5"/>
    <dbReference type="SMR" id="A0A836GVT5"/>
    <dbReference type="GeneID" id="92356552"/>
    <dbReference type="KEGG" id="loi:92356552"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050484">
        <property type="entry name" value="Transf_Hexapept/Carb_Anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13061:SF26">
        <property type="entry name" value="BACTERIAL TRANSFERASE HEXAPEPTIDE (SIX REPEATS)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13061">
        <property type="entry name" value="DYNACTIN SUBUNIT P25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5465088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="431" mass="48078" checksum="923FAAE064A485D8" modified="2021-09-29" version="1">MLRRTLRRLVPSDAIGSVHPDVLWGYQQGQYAGPGWANFIKSLPLETLTMQGGSTMANLNDRTGTFVDPEDPRHPLALMQFGLGGKMDGTFHQLAYGDFGHISKGSRLMQVLYENYLEPFSMNRVCAQLYFYQKVPNNYHASVDATAEYVGQTATLVGQVVVGMGACIMEGVTIRADTNCVYIAEGVQILENTCIMSDAPTDLLAYQRHELLNPYQQWDGMDGVTRIMPNTIIEPNCFLDSCSIGSFNRIGHNTKIMKGVTTGIMVHIMPGSVVTADTKIGDGEIWGGAPACKIGDVSKFEYKRPYYASLLHRESVAESYRNMSRYGDQFVHYTNAMGQLETLMIHYEDHVTPGVKAKVRDFEEGREPFHHTITRIAQGWSPANRPDDKNFAMAPPAPSVKLFAEHNTDSSPSDWNGSYANITNVFNDFRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GW66</accession>
    <name>A0A836GW66_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mismatch repair protein PMS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_01340</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059086.1">
        <property type="nucleotide sequence ID" value="XM_067203395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GW66"/>
    <dbReference type="SMR" id="A0A836GW66"/>
    <dbReference type="GeneID" id="92357329"/>
    <dbReference type="KEGG" id="loi:92357329"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000138">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="entry name" value="MutL, C-terminal domain, dimerisation subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="entry name" value="MutL, C-terminal domain, regulatory subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF55">
        <property type="entry name" value="REPAIR PROTEIN PMS1, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="5">
        <location>
            <begin position="270"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="MutL C-terminal dimerisation" evidence="4">
        <location>
            <begin position="660"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="110"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="493"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="112"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="496"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="508"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="520"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5466196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="847" mass="92161" checksum="F9FF36C8A020EE8F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GXM4</accession>
    <name>A0A836GXM4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_04327</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062250.1">
        <property type="nucleotide sequence ID" value="XM_067206313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GXM4"/>
    <dbReference type="SMR" id="A0A836GXM4"/>
    <dbReference type="GeneID" id="92360247"/>
    <dbReference type="KEGG" id="loi:92360247"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
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                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5468088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="551" mass="60366" checksum="9AC0392F34DA3468" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H2Z7</accession>
    <name>A0A836H2Z7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059995.1">
        <property type="nucleotide sequence ID" value="XM_067204443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H2Z7"/>
    <dbReference type="SMR" id="A0A836H2Z7"/>
    <dbReference type="GeneID" id="92358377"/>
    <dbReference type="KEGG" id="loi:92358377"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00158">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE RDL2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086:SF10">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE_RHODANESE-LIKE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="40"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5469018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="142" mass="15252" checksum="C03E0672E23456DE" modified="2021-09-29" version="1">MASLKQRNTAAPAEIEAGVTAAGPAEISAEDLHKLLHSPDKASVVVVDVRSADEYASFNIPGSINRPFQELNFAQLADEVASHANHAAHALVFVSAQSPDVDDLAARQYINEYEKSHATPLAKESVRVLLGGLYTWSQLYPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H358</accession>
    <name>A0A836H358_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small GTP-binding protein Rab18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_02505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060085.1">
        <property type="nucleotide sequence ID" value="XM_067204533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H358"/>
    <dbReference type="SMR" id="A0A836H358"/>
    <dbReference type="GeneID" id="92358467"/>
    <dbReference type="KEGG" id="loi:92358467"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01863">
        <property type="entry name" value="Rab18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001918">
        <property type="entry name" value="Small GTP-binding protein Rab18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5469108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="23844" checksum="B70A789BC69FE6AF" modified="2021-09-29" version="1">MSSATSADKTIKVLLIGDSGVGKSSLLLSFTTGAFDENISATIGIDFKMKKVDVVDAHTGGKATVNLQLWDTAGQERFRTLTSSYYRGAQAVVLVYDVNEPQSFHGLKKWLDEANSYCRRDEAESNNMVFLLIGNKTDLCFDENSMPLPRSTAQGFAQQNNMLFALTSAKTRIGVAQAFDEVARSVYEKLQDLEHYERRRITNLSDGGNSSGGGQGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H435</accession>
    <name>A0A836H435_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Thiopurine S-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_07429</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000008">
        <property type="protein sequence ID" value="KAG5486496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065562.1">
        <property type="nucleotide sequence ID" value="XM_067209319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H435"/>
    <dbReference type="SMR" id="A0A836H435"/>
    <dbReference type="GeneID" id="92363253"/>
    <dbReference type="KEGG" id="loi:92363253"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008119">
        <property type="term" value="F:thiopurine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000436">
        <property type="entry name" value="Thiopurine S-methyltransferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008854">
        <property type="entry name" value="TPMT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10259">
        <property type="entry name" value="THIOPURINE S-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10259:SF11">
        <property type="entry name" value="THIOPURINE S-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05724">
        <property type="entry name" value="TPMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5486496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="425" mass="48303" checksum="BCF4F9D7D5FDD538" modified="2021-09-29" version="1">MLRTSRMRRAGMHVPGAQELDDQVLLNRLRKSRPKRRLFFKAMTAGRMQGFVAAGGIILGAAVFLGPWLWEEVQEMMGNKYVPLPPSKMPRTSPEWWENEWRKMNPLWRAGESMSDFFAGPYGFVKEQTGRDMSSALDFVRTSPSLSSSSGVAREQQSGFLRRLTCAFRRSEAPATSHCATTASRGAEADRKGGDSCRTSASAVMLPNPPQMLVPLCGDSPIIRTAALQGFEVDAVDSSQTAIQSAVSRTEEGLPRELYSKIHLHWKNFFSPELWEGPLKGKKYDVIYERQGMTSLNREQRPDYAYLLKRALKDDGLIYVEGIFRTGRVKGNKLRGPPYSLSKRELEQLFPLSEGYYVRCEEKTDAMRQLSRENRILKRVPKELYVTPFSCVVFREATVNLRTRTEPLQHPEPPILTPPEENFVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H4F1</accession>
    <name>A0A836H4F1_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        </source>
    </evidence>
    <sequence length="254" mass="28642" checksum="485B5356D1A70720" modified="2021-09-29" version="1">MLRPCQPHRCLPIGVACRTLGFQLPPSNKRDLKKRFVQLTMESHPDLHAENEKAATARMVQLTEAYTCLKNLLEHRVQYQNGSGLSPCPQHPSNTRASSQGDAAARPHADEWAEAAASFRAPGSSISLRNFTLPWQRNTRSTATSSWEAKMREPNVSFRDFARYARDLEKDLQQREERIREDAATADGTHGFTAEYFERTQKNSAAGRGMVRHGLPSTHLVALGAFYYGRRLRYAVAQAPQTAWHALRYVLLGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H8X3</accession>
    <name>A0A836H8X3_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_04339</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062534.1">
        <property type="nucleotide sequence ID" value="XM_067206325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H8X3"/>
    <dbReference type="GeneID" id="92360259"/>
    <dbReference type="KEGG" id="loi:92360259"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5477123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="160" mass="17575" checksum="3644AF17A7BAE62C" modified="2021-09-29" version="1">MPLCRSLSSLPDSKFVPYTYCFAPGGVLSAVRGLWCFPLCAAKKLQSDLPLARSASRVNATASNGSVNVDVEHLAIICTTADCAARFCRCTLREEDMEKPPQRADTRREIEWQLCGLLLDTTRCEAASCRTFAVTSMDSATFLGYHCEGLLLCHRVDVAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HAY2</accession>
    <name>A0A836HAY2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_03614</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SYS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061548.1">
        <property type="nucleotide sequence ID" value="XM_067205611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HAY2"/>
    <dbReference type="GeneID" id="92359545"/>
    <dbReference type="KEGG" id="loi:92359545"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019185">
        <property type="entry name" value="Integral_membrane_SYS1-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12952:SF0">
        <property type="entry name" value="PROTEIN SYS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12952">
        <property type="entry name" value="SYS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09801">
        <property type="entry name" value="SYS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="321"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="332"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5473545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="379" mass="41262" checksum="CB5F6F92E4E73506" modified="2021-09-29" version="1">MAVALGRTISNPIFLLFQMLHAVSLFFVMLGVARVGLGMVELSMETAAVAERTAPPMTIHEVLLSLKGKTYAAPAPAAPQVLRRPHGLSEAVYWRANVLDSPMGDTFTVPTTKPPSGPSASSLSFFELLSYCFHVPLTSLFASPLDVRTGATTETEKVLNWGLLEANPDDLLRKDIDLSEDDAPITEGRRDLSEGRFYLQHLFAALLCSYPLATLLQRRKLVLDFVVTIYVSYWLLTNIVLQRLLGGGLHWWAACALGMSVMYGATYVLCRRKELQEVRLSGGSVVAPGAGVPPTTTMWLKDCRGEDDMIGEEMRVVLRETPRPNGAGGCAESHDNSSPHDAPGRVRIPASALSSNNAKAVTVDVNRPSEEVPHKHKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HB21</accession>
    <name>A0A836HB21_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="14">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">LSCM4_03675</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="14"/>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061608.1">
        <property type="nucleotide sequence ID" value="XM_067205671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HB21"/>
    <dbReference type="SMR" id="A0A836HB21"/>
    <dbReference type="GeneID" id="92359605"/>
    <dbReference type="KEGG" id="loi:92359605"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14298">
        <property type="entry name" value="UBA2_scUBP14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000094">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000208">
        <property type="entry name" value="Ubiquitinyl hydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033864">
        <property type="entry name" value="UBA2_scUBP14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016652">
        <property type="entry name" value="Ubiquitinyl_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041432">
        <property type="entry name" value="UBP13_Znf-UBP_var"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF664">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17807">
        <property type="entry name" value="zf-UBP_var"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016308">
        <property type="entry name" value="UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
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                <person name="Bates M.D."/>
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                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5474715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="37625" checksum="0DF3C840035C6B3D" modified="2021-09-29" version="1">MRVQGNSVSQRHQVSQRESDDENYTGSSGSYTEFSGSPPRLQQQQLSSAVAGAQRTPRMEQGSLTSGLQPSPSSVNRGAAQGHQHEEGGETAQEKSGAARGRQKVLTRVNAALEAPAARMRAVTNAVVGKDSQRVTIYVFFCVAWAHLLFVILFSALSQIDMTGGGCYTFWGFKKNCDTVSYTRRTSLIKNCRGLRSSLKTGAAFSILAILASTVTLITSWLLCIRLREAHRYPGDQSRYMDVDVTELGAEAATLNNSNENRKQGNEALFNAGTLKKVMMIVIAFDLAFQLICWSITASIYTHQYCDNIYHWSTSASYGVGFGIGLTAWLMELIAFIPFIMLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HDT5</accession>
    <name>A0A836HDT5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_07873</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000013">
        <property type="protein sequence ID" value="KAG5484307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064800.1">
        <property type="nucleotide sequence ID" value="XM_067209750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HDT5"/>
    <dbReference type="SMR" id="A0A836HDT5"/>
    <dbReference type="GeneID" id="92363684"/>
    <dbReference type="KEGG" id="loi:92363684"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF33">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="86"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5484307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="669" mass="73938" checksum="0156ABE3608C17B7" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HG97</accession>
    <name>A0A836HG97_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Folate/biopterin transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_06583</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Folate-biopterin transporter (TC 2.A.71) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000010">
        <property type="protein sequence ID" value="KAG5485627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065211.1">
        <property type="nucleotide sequence ID" value="XM_067208500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HG97"/>
    <dbReference type="GeneID" id="92362434"/>
    <dbReference type="KEGG" id="loi:92362434"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039309">
        <property type="entry name" value="BT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004324">
        <property type="entry name" value="FBT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00788">
        <property type="entry name" value="fbt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31585">
        <property type="entry name" value="FOLATE-BIOPTERIN TRANSPORTER 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31585:SF51">
        <property type="entry name" value="TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03092">
        <property type="entry name" value="BT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="396"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="427"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="457"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="492"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="524"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="562"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="605"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="650"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5485627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="682" mass="75394" checksum="1EDCCB63C042D4F8" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HHR0</accession>
    <name>A0A836HHR0_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_07916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000013">
        <property type="protein sequence ID" value="KAG5484350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064843.1">
        <property type="nucleotide sequence ID" value="XM_067209793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HHR0"/>
    <dbReference type="SMR" id="A0A836HHR0"/>
    <dbReference type="GeneID" id="92363727"/>
    <dbReference type="KEGG" id="loi:92363727"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="742"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="869"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="917"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
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                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Bates M.D."/>
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                <person name="Bates M.D."/>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5485715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="133" mass="14093" checksum="793B3DDBEEE2503C" modified="2021-09-29" version="1">MVLIDKLKTLVGRSLGSRSGNALTCSTGAAPPTFAEAWNQAKAMTNKLFEEREWQCPCGHKFRAAGEWVACAPIYCEVPSCPNPKYYIDGPGRALLEANPSGVKLEEVSTSGGSATSHADSGKKTGGVGSRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HKW2</accession>
    <name>A0A836HKW2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATG8/AUT7/APG8/PAZ2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_06706</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000009">
        <property type="protein sequence ID" value="KAG5486000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065331.1">
        <property type="nucleotide sequence ID" value="XM_067208620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HKW2"/>
    <dbReference type="SMR" id="A0A836HKW2"/>
    <dbReference type="GeneID" id="92362554"/>
    <dbReference type="KEGG" id="loi:92362554"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000221">
        <property type="entry name" value="Autophagy-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5486000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="13747" checksum="166A3D5DBA0EE9EC" modified="2021-09-29" version="1">MSAYMSSTPLEARVAKCASLRAANAVPVVVEEAQSRGGKAHFSALARETTVAQLVAAVRGFRGVDAKKPVALTVVGCSVSPSATLGELHDACKQADDGMLYVAYTAERSMGAAVWTPCGACGWNGKSSEEVII</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HLZ8</accession>
    <name>A0A836HLZ8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aspartate/glutamate/uridylate kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_06213</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000020">
        <property type="protein sequence ID" value="KAG5480446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063777.1">
        <property type="nucleotide sequence ID" value="XM_067208137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HLZ8"/>
    <dbReference type="SMR" id="A0A836HLZ8"/>
    <dbReference type="GeneID" id="92362071"/>
    <dbReference type="KEGG" id="loi:92362071"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004349">
        <property type="term" value="F:glutamate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04242">
        <property type="entry name" value="AAK_G5K_ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000006">
        <property type="entry name" value="Glutamate 5-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00456">
        <property type="entry name" value="ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041739">
        <property type="entry name" value="G5K_ProB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011529">
        <property type="entry name" value="Glu_5kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005715">
        <property type="entry name" value="Glu_5kinase/COase_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019797">
        <property type="entry name" value="Glutamate_5-kinase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01027">
        <property type="entry name" value="proB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43654">
        <property type="entry name" value="GLUTAMATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43654:SF3">
        <property type="entry name" value="GLUTAMATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000729">
        <property type="entry name" value="GK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00902">
        <property type="entry name" value="GLUTAMATE_5_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aspartate/glutamate/uridylate kinase" evidence="8">
        <location>
            <begin position="9"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5480446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="265" mass="28980" checksum="1895009BD191D81A" modified="2021-09-29" version="1">MSGILNSVKRLVVKVGSSILVENQQVALHRIEALCTFLADLKSTYEVILVTSGAVAAGYTKKEIDKSLETNKQVLASIGQLLLMHVYYTEFQKHGILCAQVLFGAREIDSCKRAVADHNAIEALLTHKVIPIINENDAISPRELLFGDNDCLAAHVAYHFNADMLVILSDIDGYYTANPRTCADAKMRLIVHEVSPDELVAEATPNNRFATGGIVTKLQAAQFLLERGGKMYLSSGFQLEKVRDFLLGGHHHTGTLFLPSAVTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HN92</accession>
    <name>A0A836HN92_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063424.1">
        <property type="nucleotide sequence ID" value="XM_067207651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HN92"/>
    <dbReference type="GeneID" id="92361585"/>
    <dbReference type="KEGG" id="loi:92361585"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5479713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="184" mass="20747" checksum="F39C3C152F4AD33E" modified="2021-09-29" version="1">MDAGYGSWKAARPRAHLMILYLFMFTDLINLICYILYLFPSRKVYGVYVTNVYIIFACIGLAVFVGVSSPLIYWPYAHGSEMSPVSRQNALFLGLAISLLAHDCPMVWVELWLVTTFGWTEILQAISLFLTLLCFIISFLVTWIAYSWKLSKVLQIRYGDAASGPSAVPAAQFARRSSSRAYCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HPJ4</accession>
    <name>A0A836HPJ4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA uridylyltransferase</fullName>
            <ecNumber evidence="1">2.7.7.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_06139</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">LSCM4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>RNA(n) + UTP = RNA(n)-3'-uridine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14785"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17348"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173116"/>
            <dbReference type="EC" id="2.7.7.52"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.52" evidence="1"/>
    <dbReference type="EMBL" id="JAFHLR010000020">
        <property type="protein sequence ID" value="KAG5480373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063704.1">
        <property type="nucleotide sequence ID" value="XM_067208064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HPJ4"/>
    <dbReference type="SMR" id="A0A836HPJ4"/>
    <dbReference type="GeneID" id="92361998"/>
    <dbReference type="KEGG" id="loi:92361998"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050265">
        <property type="term" value="F:RNA uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000069">
        <property type="entry name" value="Mitochondrial editosome-like complex associated TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF97">
        <property type="entry name" value="MITOCHONDRIAL EDITOSOME-LIKE COMPLEX ASSOCIATED TUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="3">
        <location>
            <begin position="14"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00049105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5480373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="409" mass="46604" checksum="AEC4206AD74593D1" modified="2021-09-29" version="1">MQTGKRKFMAESIARYRASQLTPNDKEAIADLQLRMLDLCSRCVNKAQLVLFGSLATGFCTSGADADLSLTFRNFSPWLNGLDRVDEQNGKRLARVGREAGETGMENVRFINARIPVVQFQDPTSGIRCDITIGNLGGVENSKILSEIRRVLPDFYGAYVYLVKEWAKRCEVVAPEKSMLNSFTITTMALMVLQELGLLPIFVPTGTFGELTLTDVERVLGSWKLPPVYEGIEQDDERLGEALYFCLLRFAEYYSKFDFGHGTVSLMCPRRHRSLYAKIVKQHIQLLGERKKKEWCAYLLGGQDDRASSTISSHFPQRSFDESMRHEAVQRQADTAFVVEDFVNYVNCGRRVPAARGPKVHLEFKRLYELLRNEAHVGFDEVFRETQSIPLTHMPDRPDPRVEVFHTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HQK4</accession>
    <name>A0A836HQK4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_05637</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000016">
        <property type="protein sequence ID" value="KAG5482381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064387.1">
        <property type="nucleotide sequence ID" value="XM_067207573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HQK4"/>
    <dbReference type="SMR" id="A0A836HQK4"/>
    <dbReference type="GeneID" id="92361507"/>
    <dbReference type="KEGG" id="loi:92361507"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000737">
        <property type="entry name" value="Protein kinase putative (CRK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF552">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 2 HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="7"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="151"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5482381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="466" mass="51816" checksum="11DD6A5FD15D3D28" modified="2021-09-29" version="1">MSTAGRYKHVVKLGEGTYGSVYKGTEIQTGKVVAFKRMVVTSDDEGVPGAAIREICLLKELRHDNVVDLFEVLFEPPKITMIFELCDCDLKRFMESRPRRLLDAETEMRPILKQIFIGLEYLHSRNVVHRDMKPQNIFVNVRAPDFAALTASHQPHPQPPHFSGVPADVGGDGQLTAGPSGRPDPFAGAGSVSPWEAAAAGPQSTPNQLIVKIGDFGLARVEEIPVKKYSHEVVTLWYRSPDVLMGSALYAYPVDIWSMGAIFFEMATGKVLFSGRHEDEQLLRMFWLLGSPTRETWPSMLSYPGTMERLERASRAAADRSDLRFASDVHVQQQQQSPASQPQGGSRSPDLLTQMAHKRFYHSSQATQQREESARSSPNTYRLPVELWFDRPLFDEYMSATGLDGGVTAEGVDLLRQCLLYEPSYRITAAAAVRHAYLHAVPVPTAGALDVLMTSLLQTMEACHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HQW7</accession>
    <name>A0A836HQW7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_07010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000018">
        <property type="protein sequence ID" value="KAG5481300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063979.1">
        <property type="nucleotide sequence ID" value="XM_067208916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HQW7"/>
    <dbReference type="SMR" id="A0A836HQW7"/>
    <dbReference type="GeneID" id="92362850"/>
    <dbReference type="KEGG" id="loi:92362850"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000580">
        <property type="entry name" value="Putative mitochondrial NADH-ubiquinone oxidoreductase complex I subunit,FT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051207">
        <property type="entry name" value="ComplexI_NDUFA9_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126:SF6">
        <property type="entry name" value="3-BETA HYDROXYSTEROID DEHYDROGENASE_ISOMERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 39 KDA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-beta hydroxysteroid dehydrogenase/isomerase" evidence="1">
        <location>
            <begin position="92"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5481300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="479" mass="54133" checksum="0384DC007D506662" modified="2021-09-29" version="1">MQRFSVRFSSAVATVGGARTFWDPFGHQPESMFLDRKDLNQMYPTQKPQTTGGGFGYERGPYWAAMLLPNPAVRLPHERRRLNPKPAKRVTVFGASGYLGAEIVRELCEHPDIEKVRATTRYPTLIPQGSDLDVLLRAYPDKLELHECDVTDRIQVNVAANGSDTLIFAVDYHAEYANNSHHDVFLIGATNVSWTARSVRAERVIFCNGLDATFASESNYVDFRARGEDAVGANHPDATIIRFGPLYGRNYRYRGLGRYVYPACFPNTKVQPTWVVDAARAVVRCSMSHRAVRYKFDLGGPQTMSHVEAFREIARHFEKRLVVPCYRGFGRFFGKLATWTVPNPWFDDNYILTFELDQVNRRSTLFDRLASWDRIAYKPHTIREAAEIERGSRKLAPLHELDVAFKQLEAADKAAFEQEEEAAKTFGIYRAKAEPGFGRTDGLEALAQEIYPGQQFRVKPLKGATYPSSVAHPGPTAIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HTR0</accession>
    <name>A0A836HTR0_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000016">
        <property type="protein sequence ID" value="KAG5482428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064434.1">
        <property type="nucleotide sequence ID" value="XM_067207620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HTR0"/>
    <dbReference type="GeneID" id="92361554"/>
    <dbReference type="KEGG" id="loi:92361554"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5482428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="152" mass="15814" checksum="38F6B94615757234" modified="2021-09-29" version="1">MFTASCAMSPFVSSSRNARTRTYTFTRLLCFIASARRMPTAVALRLKAPLLPVPEALRSKAEVAGGRGDSGAAERADGGPDIRGGRGGVGLPIEEGATPAGAGGVGTARAELFLSGVVERLGVTTPTGWPRRPDASGPRDEFDRLNSISTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HZH5</accession>
    <name>A0A836HZH5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Flagellar protofilament ribbon protein-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_06668</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="9">Microtubule inner protein component of sperm flagellar doublet microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RIB43A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000010">
        <property type="protein sequence ID" value="KAG5485710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065294.1">
        <property type="nucleotide sequence ID" value="XM_067208583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HZH5"/>
    <dbReference type="SMR" id="A0A836HZH5"/>
    <dbReference type="GeneID" id="92362517"/>
    <dbReference type="KEGG" id="loi:92362517"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008805">
        <property type="entry name" value="RIB43A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14517:SF6">
        <property type="entry name" value="RE41410P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14517">
        <property type="entry name" value="RIB43A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05914">
        <property type="entry name" value="RIB43A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="5 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0282">Flagellum</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="130"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="344"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5485710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="396" mass="46898" checksum="AA47930E9E6742F2" modified="2021-09-29" version="1">MDSAAQTQSGFTATSSRGTEAASAVKTTSAWGPMNVKSKKQLFMLQRAERLKDPKVRKMGIDREALDAQVREKEALRRLEKERDDYYDRQALLMDRHACALQQEVNAIRAAREKELQDYRQTFQKKELGREWDLNDPEARRKELPARVGDNDPRNGPSSLQKLEGEDLDYAARKAAQQRQQRQWAQQQVNEKLAKKWMEQERDRAFDDRNEETNYRLYEVEKKVAEQRRLMEKNGADFNRALAEQQRREAVRAKEEDTRLGLEEIAYQMNSDFLNERETVVSELGASVKAERYKGMSDKQKALLRSAQDEQLRELRRRRLLEVEEEKQWSQQEHMQLRMANALDRQRERERRAEREQLAETQRMQARAAAQRKAELDELYTNAVDEDYFKYWDRCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836I1Z4</accession>
    <name>A0A836I1Z4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Splicing factor ptsr1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000007">
        <property type="protein sequence ID" value="KAG5486880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065674.1">
        <property type="nucleotide sequence ID" value="XM_067208269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836I1Z4"/>
    <dbReference type="SMR" id="A0A836I1Z4"/>
    <dbReference type="GeneID" id="92362203"/>
    <dbReference type="KEGG" id="loi:92362203"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5486880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="366" mass="41105" checksum="EF36C895F3027F01" modified="2021-09-29" version="1">MSQSLSRSGSRSGSASRSASRSASGSRSRSRSSSNSMRLPEPTTTSTNGDEPAVAPVAAAATTTTDNGGQPPAPEKEVASIFIGMGPAGRTVTLPELTEYLKSKAIDPSNVKDVRLRGRCAFADTTTVEEARHLIAELDNEDYKGKFRLAVQMSKQTMAEAKENKRKRQEVRGIKPVDESRYVNEGRQVFVNLGPAGKDISSDIIRSKIEAISPIIRFERRGYCLYVDVPSAEDTKRVVSALNNMMVGDVRVLVQISTMVRKRERSPQRVRDVVRRGSDRHDRDLHRYRRRSDSRGRRSYSPGSEDSRDRRSRRGGYHGSEHRRGGRGERGSDRRERRGDDRRGDDRRGDDRRGDDRRGDDRRSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836I210</accession>
    <name>A0A836I210_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="14">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">LSCM4_06363</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. PIF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="14"/>
    <dbReference type="EMBL" id="JAFHLR010000007">
        <property type="protein sequence ID" value="KAG5486895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065689.1">
        <property type="nucleotide sequence ID" value="XM_067208284.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836I210"/>
    <dbReference type="GeneID" id="92362218"/>
    <dbReference type="KEGG" id="loi:92362218"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18037">
        <property type="entry name" value="DEXSc_Pif1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002849">
        <property type="entry name" value="ATP-dependent DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF5">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="382"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="166"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="951"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="977"/>
            <end position="995"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG5486895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1321" mass="143220" checksum="6EB911AA87658D59" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836I3B9</accession>
    <name>A0A836I3B9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LSCM4_08060</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">LSCM4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Probably involved in the control of the cell cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="JAFHLR010000005">
        <property type="protein sequence ID" value="KAG5487615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065903.1">
        <property type="nucleotide sequence ID" value="XM_067209936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836I3B9"/>
    <dbReference type="SMR" id="A0A836I3B9"/>
    <dbReference type="GeneID" id="92363870"/>
    <dbReference type="KEGG" id="loi:92363870"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010389">
        <property type="term" value="P:regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07829">
        <property type="entry name" value="STKc_CDK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000574">
        <property type="entry name" value="Cell division related protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000124">
        <property type="entry name" value="Cyclin-dependent kinase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF527">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 2 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="33"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG5487615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="331" mass="37435" checksum="38850A40BFCC53C9" modified="2021-09-29" version="1">MHVAVPPSPLRGSAEAMRSSGPAPARLTGFQRYQRQHKVGEGSYGKVFLCTDVVGGGTVAVKTSQWNSGEEGLSVSSIREVSLLKEIRHPNVVRLLDLFTEEKKLCIVFERMEKDLRSVLSTRQTPIVGRKLKHMMYQLLSALHACHSRRVVHRDIKPGNILVSADEQTVKLADFGMGRAFGLALQSYTYRIATLYYRAPEVLLGDRYYLPSVDMWSMGCVMAELALRRALFRGEGEYSQLITIFGIMGTPNECVWPGVSRLPHYNAEFPSWVPTSLEKHIPTLDPEGIALLKAMLRYDPQRRITALQAMQHPFFDDVRDECEARLQQYQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836I456</accession>
    <name>A0A836I456_9TRYP</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">LSCM4_08275</name>
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    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
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            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
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            <taxon>Leishmania</taxon>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000003">
        <property type="protein sequence ID" value="KAG5488050.1"/>
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    <dbReference type="KEGG" id="loi:92364078"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="38"/>
            <end position="80"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5488050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="318" mass="33820" checksum="B850881EEC816DC1" modified="2021-09-29" version="1">MRQFTYRTALTAAASLAAHATVTTRRGCYASSHVGISGAPAAEPSPSSSARYRHSSVPPRHARPVGARGPVKDRFPPVPTDLADPRRRLAVLVDGSNPNLIPGGCSTVDEVYRTSALFTTALPAVLQVGIPVLLRVFAHRLPAAWEPLLAGSSAAHGGTACAGHNAPTDGAGRPISLIPLPFPSSPPSAAPPTTAAGDALAVPQVQFEYFRVERFIPVAMQMEADARHIYELRHTNKVEGVCYICHEVDRAMFISLMEEQRMGSVELEELLREVTGKGGKTGANGERAAEAAFFNQYVLDEFGMAGELLTDSRSKNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KA54</accession>
    <name>A0A836KA54_9TRYP</name>
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        <submittedName>
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        <name evidence="2" type="ORF">LSCM4_00042</name>
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    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Trypanosomatida</taxon>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="182"/>
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        <location>
            <begin position="385"/>
            <end position="523"/>
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            <begin position="50"/>
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        <location>
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        </location>
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        <location>
            <begin position="401"/>
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        </location>
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        <location>
            <begin position="441"/>
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        <location>
            <begin position="460"/>
            <end position="479"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="EMBL" id="KAG5464602.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="536" mass="54810" checksum="69EF0E1ECA65CB63" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KB97</accession>
    <name>A0A836KB97_9TRYP</name>
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    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067204818.1"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A836KB97"/>
    <dbReference type="GeneID" id="92358752"/>
    <dbReference type="KEGG" id="loi:92358752"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GOLD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CRAL-TRIO_dom"/>
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        <property type="entry name" value="SEC14/CRAL-TRIO_domain"/>
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    <dbReference type="PANTHER" id="PTHR23324">
        <property type="entry name" value="SEC14 RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23324:SF83">
        <property type="entry name" value="SEC14-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
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        <property type="match status" value="1"/>
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        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
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    </dbReference>
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        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
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            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5470104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="478" mass="53570" checksum="AA1FB24A8BA38D28" modified="2021-09-29" version="1">MSSFILQPALLFQPITVKSEERITQVLETVRAQHAPGLPVLFQRAADRGTSDLPTSQNDLRLLAYAFLVARNWSVKDAVKMASDACRFYDKFHLTEHSLFPSGFSIRGYDQASVAAWIRLPMGTSNTPLYRCMQTMTPLVHGGFHYWDRHGLPVAYWLVGRMDTHSVLRKLKPHIPVGMSVEDFFQLFGGGIIETGWALCNYQDAVLTAHPQPGIDMGAPRRNFCTIVVDCKGLSYKMIHRQLLEKTKATLQQMNCVFADFIHRVLVVNCPPMVKFAYRLLRSAVNEGVQAKMTFVSPENTAAVLHQVIGLERVPAFLGGSCNCEGGCLGSYNPDATFTAEEFGDDGDITTENITVSPGKKHEKVFELQQGEEVIWEFSTTKGTDVRFSVMFYPRQEGVRAQSKSGKMRVRIDKSTKRTTTESPVVKQEKLKEGADSYMAPEDGILQLVWDNSKSIVSDKGIQMRVYKSEAMMESPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KBP2</accession>
    <name>A0A836KBP2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP-binding cassette protein subfamily C, member 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_00830</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059553.1">
        <property type="nucleotide sequence ID" value="XM_067202903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92356837"/>
    <dbReference type="KEGG" id="loi:92356837"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF273">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="599"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="749"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1455"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1560"/>
            <end position="1578"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="554"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1013"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="1459"/>
            <end position="1712"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1757"/>
            <end position="2078"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="355"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="654"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="982"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1278"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1727"/>
            <end position="1748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="988"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1007"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1302"/>
            <end position="1319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5467751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2078" mass="225918" checksum="AE7A302B2D857CE4" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KBT6</accession>
    <name>A0A836KBT6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_01673</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059412.1">
        <property type="nucleotide sequence ID" value="XM_067203721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KBT6"/>
    <dbReference type="SMR" id="A0A836KBT6"/>
    <dbReference type="GeneID" id="92357655"/>
    <dbReference type="KEGG" id="loi:92357655"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000117">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115:SF799">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115">
        <property type="entry name" value="KINESIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="2">
        <location>
            <begin position="48"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="141"/>
            <end position="148"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5466522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="480" mass="53308" checksum="B20A573C496E4E56" modified="2021-09-29" version="1">MPSIPLVTELGARAEEFQHILNISKIPPQVEQKLRPAMDPDELFTYQDSRIFVRARPIVPHDMEDPNNQSIVQKVDENRDLVVMTPKISLSGECTIDPCVVPLDGVFVGASDGTERVYLESCAPLVSLSVDGASTCVLCYGQTGSGKTYTTSGIFRLVAEDLTPVFSTHDILLTVLEIQVLKTIDLLTGTDVQVMEDVSGEVKLLGTEPFECSSAEMLLAAFEEAASQRTARSTERNETSSRSHMIARISIVSKETKWAKPGDLFIVDLAGSENTADSATHDKIRQAETKFINTSLMTLKDCIRSRALASSSTQHLHIPYRRSPLTLLLRDCFEIAVRRPTKTVMIACVSPLLRDSRHTINTLRYASMLAVTPPAKVVAPDPNDPNNYTREQALSFLSKVSHGNITQPEHILPEGDGRTLVHIPEAEFIRRIVESHPHIPEKKAKLIYTAVWKRIVDARTKGRKQMIDAKRHIKAPRCAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KBX1</accession>
    <name>A0A836KBX1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_00623</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058801.1">
        <property type="nucleotide sequence ID" value="XM_067202700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KBX1"/>
    <dbReference type="GeneID" id="92356634"/>
    <dbReference type="KEGG" id="loi:92356634"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="312"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5465170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="718" mass="80465" checksum="B1166D1FCE1ED5AF" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KCU5</accession>
    <name>A0A836KCU5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aldose 1-epimerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_01272</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldose epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059020.1">
        <property type="nucleotide sequence ID" value="XM_067203329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KCU5"/>
    <dbReference type="SMR" id="A0A836KCU5"/>
    <dbReference type="GeneID" id="92357263"/>
    <dbReference type="KEGG" id="loi:92357263"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09019">
        <property type="entry name" value="galactose_mutarotase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047215">
        <property type="entry name" value="Galactose_mutarotase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091">
        <property type="entry name" value="ALDOSE-1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091:SF0">
        <property type="entry name" value="GALACTOSE MUTAROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5466130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="377" mass="41802" checksum="B8CAA327DDA3EB11" modified="2021-09-29" version="1">MTFHIEVCPFGAGKMVWLKTDCLRVGLANFGATTSSVQVFHPKQQKWIEVNCAYPTSAAETEADTDYMGVTAGRCGGRVAYATFKLDGVTYRTDKNMAGSHTCHGGYNAFNKKHWGLTVTETATEIGVTFNYTSAHMENGFPGELVSKVIYSIERAKPNVLKTRFDGYISETSPADACPVNIFNHAYWNLNGVPECNGKHDAVWKQPESVRNHWLRVPASRVAEADRVAIPTGEFLPVEGTGLDFRKGRVIGECIDDVALLDRDPCGYDHPLAIDGWEKGKLMLHAEAKSPVTNICMKVYSTFPCMWVYTANNKPLPASGGPGQRYARWTGMGLEPQYFPDAANHYPKYPSCIVRRGKNRFEETIINEFTVGSNSNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KD46</accession>
    <name>A0A836KD46_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_01125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5468037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059839.1">
        <property type="nucleotide sequence ID" value="XM_067203189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KD46"/>
    <dbReference type="GeneID" id="92357123"/>
    <dbReference type="KEGG" id="loi:92357123"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5468037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="115" mass="12284" checksum="69DAED13B95F224B" modified="2021-09-29" version="1">MGHLRHRFECSDAMQVIVDEVSTLDMLLSTGGRCEHSWQYIGECHGMGIPSAVLEAVPEKEACVDVSSGAPKALALLSYSVQGAFEACRDSAMPEYSPRDIVLTAVHEACAVDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KEV7</accession>
    <name>A0A836KEV7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TFIIH basal transcription factor subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060328.1">
        <property type="nucleotide sequence ID" value="XM_067204776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KEV7"/>
    <dbReference type="GeneID" id="92358710"/>
    <dbReference type="KEGG" id="loi:92358710"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="505"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5470062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="566" mass="62160" checksum="F2BB66004F8100C3" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KF63</accession>
    <name>A0A836KF63_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060658.1">
        <property type="nucleotide sequence ID" value="XM_067205106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KF63"/>
    <dbReference type="SMR" id="A0A836KF63"/>
    <dbReference type="GeneID" id="92359040"/>
    <dbReference type="KEGG" id="loi:92359040"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045136">
        <property type="entry name" value="Iah1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209:SF19">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5470392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="254" mass="28461" checksum="04C2D45B6DDF776D" modified="2021-09-29" version="1">MESVLLLGDSITQQGYCSGWVSRISDALVRRAHVVNSGLSGYNTRWLLEILRDPKRCQSIIPAWVHEPLFVTVMMGSNDCAEGGQHVPVSEFRENLRAILEIVLSKVNPRGGVYVLTLPPVHQDVWNASHPERKRYFAATRLYRQATLQVSRELSAQHPLRVFAVDMQAAFLRYGAPEASESEMDVYDPGGAWTSLLVDDGLHINTEGGHLFSSTLLSAVRKSPEGVRVLQNNEEVWPLPDWLTVMSKQKPEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KG58</accession>
    <name>A0A836KG58_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GRAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_02191</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061262.1">
        <property type="nucleotide sequence ID" value="XM_067204225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KG58"/>
    <dbReference type="SMR" id="A0A836KG58"/>
    <dbReference type="GeneID" id="92358159"/>
    <dbReference type="KEGG" id="loi:92358159"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140268">
        <property type="term" value="C:endoplasmic reticulum-plasma membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120015">
        <property type="term" value="F:sterol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051482">
        <property type="entry name" value="Cholesterol_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319:SF4">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRAM" evidence="2">
        <location>
            <begin position="624"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5472866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="730" mass="77767" checksum="79A4A93B6FD19670" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KGR1</accession>
    <name>A0A836KGR1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Aminomethyltransferase</fullName>
            <ecNumber evidence="2 8">2.1.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 8">Glycine cleavage system T protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_00411</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[protein] + (6S)-5,6,7,8-tetrahydrofolate = N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16945"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10492"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="2.1.2.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the GcvT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.10" evidence="2 8"/>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058594.1">
        <property type="nucleotide sequence ID" value="XM_067202493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KGR1"/>
    <dbReference type="SMR" id="A0A836KGR1"/>
    <dbReference type="GeneID" id="92356427"/>
    <dbReference type="KEGG" id="loi:92356427"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004047">
        <property type="term" value="F:aminomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006546">
        <property type="term" value="P:glycine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.110:FF:000003">
        <property type="entry name" value="Aminomethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1400:FF:000001">
        <property type="entry name" value="Aminomethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.110">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1400">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1250.10">
        <property type="entry name" value="Aminomethyltransferase fragment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006223">
        <property type="entry name" value="GcvT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GcvT/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GcvT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCVT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00528">
        <property type="entry name" value="gcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001567">
        <property type="entry name" value="PRK00389.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757:SF2">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006487">
        <property type="entry name" value="GcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="GCVT N-terminal" evidence="9">
        <location>
            <begin position="10"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Aminomethyltransferase C-terminal" evidence="10">
        <location>
            <begin position="294"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR006487-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5464963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="377" mass="41312" checksum="E6191A1534248751" modified="2021-09-29" version="1">MCTSLKKTALHSFHLAQQAKMKAFAGYHMPISYSKLGVLKEHLYTREVAGIFDVSHMGQYEVRGADRERFMEYVTPIDLQRTQVGQGALTMLTNAQGGIKDDCIVTKMADHLFLVLNAGCKEKDVAHMEAVLREGAMKGADVQFVPLERSLVALQGPQAAAILSEFMDGVPDLDFMHCRGKANIKGMEVQVTRCGYTGEDGFEISVSNKDVVALVELFVSRKAEMVGLGARDSLRLEAGLNLYGHELTEETNPVAARFMWSISKRRMEEGGFIGYEPIKGFRDNASKGAVPRLRVGLVSTGPVARGHTAIEVSGKQVGEVTSGGPSPCLKKNIALCYLDRGLAKKGVKVDLVVRNRRVPAEVVTPPFVPAHFYRKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KHC8</accession>
    <name>A0A836KHC8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_05030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062307.1">
        <property type="nucleotide sequence ID" value="XM_067207004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KHC8"/>
    <dbReference type="GeneID" id="92360938"/>
    <dbReference type="KEGG" id="loi:92360938"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF7">
        <property type="entry name" value="IMPORTIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5476074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="974" mass="104633" checksum="D4F29EEB53C7987C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KHU1</accession>
    <name>A0A836KHU1_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059008.1">
        <property type="nucleotide sequence ID" value="XM_067203317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KHU1"/>
    <dbReference type="GeneID" id="92357251"/>
    <dbReference type="KEGG" id="loi:92357251"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040183">
        <property type="entry name" value="THUMPD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13452">
        <property type="entry name" value="THUMP DOMAIN CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13452:SF10">
        <property type="entry name" value="THUMP DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5466118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="424" mass="46367" checksum="16190621E86A4CA2" modified="2021-09-29" version="1">MKHSYRDNKPRFHKHRQGQMLLPHNHLAGLFLTVNPQQERRAQREAQLYLSTLTSDLEAAHEAFLRSNYATFSGTGNAARGTSSGQVGATVPQPSASLSSLLAAELEACSKQEANGNRFNGAKRPRAEDDVVNEDSPADNDADGAPGRCHRRDMTQRRSEWFAPLETGCKGYLFLNVPTVNAMVTCPTCHAAPNLATETEDATATSRASDAESLTTEADALPPHTIVVNPLVSRITERIFDDLAANPRPIFRSCFRLMPAELTCCPTLPEMQTALRKLLALHFAADMVNSTVAGDDRVDFAQRISLPSWGADRPRRSMHTIALQLTVKNNTNVEQKKSAIATALMAAIPANRFIVVTQSSQKTKCAVEATVCVFVAHATCAMGVQRRFTERHGFNLHAVGEDAFVLSNAIQAPPKGKQRNVQQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KI15</accession>
    <name>A0A836KI15_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transport protein particle (TRAPP) subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_01523</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059263.1">
        <property type="nucleotide sequence ID" value="XM_067203572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KI15"/>
    <dbReference type="SMR" id="A0A836KI15"/>
    <dbReference type="GeneID" id="92357506"/>
    <dbReference type="KEGG" id="loi:92357506"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990070">
        <property type="term" value="C:TRAPPI protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14943">
        <property type="entry name" value="TRAPPC5_Trs31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000016">
        <property type="entry name" value="Transport protein particle (TRAPP) subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016696">
        <property type="entry name" value="TRAPP-I_su5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902">
        <property type="entry name" value="41-2 PROTEIN ANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902:SF0">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5466373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="209" mass="23624" checksum="93BCE60ED6D23D9F" modified="2021-09-29" version="1">MRQRNITAGKAFSDKGGVTSDLSSSEHTQVALSAFSFLFSELCVRAYTFPTKVKNVEEVEARLTSLGAHVGTRLIMLSSVRDSVDLQRRPLSIDAVLKLLQEKLWARWFGRAASEIQRESNSDRFFLFDSDPIVLRYVHPSPDYIDSEGRWNVNYAGFMGGIIQGALQSMGFEAEVQTYHQPGPGKPHQSLFVIAFAKHVWDRERKMHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KJH8</accession>
    <name>A0A836KJH8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">glucose-6-phosphate 1-epimerase</fullName>
            <ecNumber evidence="3 5">5.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_01065</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:16249"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58247"/>
            <dbReference type="EC" id="5.1.3.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glucose-6-phosphate 1-epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.15" evidence="3 5"/>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059780.1">
        <property type="nucleotide sequence ID" value="XM_067203130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KJH8"/>
    <dbReference type="SMR" id="A0A836KJH8"/>
    <dbReference type="GeneID" id="92357064"/>
    <dbReference type="KEGG" id="loi:92357064"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047938">
        <property type="term" value="F:glucose-6-phosphate 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09020">
        <property type="entry name" value="D-hex-6-P-epi_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025532">
        <property type="entry name" value="G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11122">
        <property type="entry name" value="APOSPORY-ASSOCIATED PROTEIN C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11122:SF13">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016020">
        <property type="entry name" value="PHexose_mutarotase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR016020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR016020-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5467978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="301" mass="32991" checksum="247C9DFD11504F7D" modified="2021-09-29" version="1">MASFTPDSCGRNSIIVHNEDGSSITVYEQGAHLSSWKSKDGKEHLYLSPKAIFADRTALRGGVPLIFPQFGAYGPLLPSHGFARIRPWNVDDVQNGKVTFSLRVALFELLPEGDALTDSPQNAVSLLFTIYFSNIALKLHMKVTNMSEEQAAPFQFAFHTYLAVSDISQTVVNGVNRSPFIDNTKSCGNPQTRPSPPESLWTIRGEHDRIYPNQACAIVLQDLGAKAALQISSPNLSDVCLWNPGPEKCAAMKDMPPDGYQHFVCVEHGNMLKKVLVPPSSSWTGTQEISILTESPCDSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KK40</accession>
    <name>A0A836KK40_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_04434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062627.1">
        <property type="nucleotide sequence ID" value="XM_067206418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KK40"/>
    <dbReference type="GeneID" id="92360352"/>
    <dbReference type="KEGG" id="loi:92360352"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="733"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="793"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="826"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1053"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="322"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="359"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="733"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="767"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="833"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="875"/>
            <end position="889"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5477216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1165" mass="123789" checksum="594BB9CC70548F8A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KKA5</accession>
    <name>A0A836KKA5_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_05033</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062310.1">
        <property type="nucleotide sequence ID" value="XM_067207007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KKA5"/>
    <dbReference type="SMR" id="A0A836KKA5"/>
    <dbReference type="GeneID" id="92360941"/>
    <dbReference type="KEGG" id="loi:92360941"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5476077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="478" mass="50147" checksum="FEB76BCADBC4EAB6" modified="2021-09-29" version="1">MSSHSTQPSSGISPPTGRTIRGAAPAAAGAKMPTSFAITGGGVSDGYRRIQIPWRQISKQQLESICRALSDRETDSPIRIIDFIDNQLGPAAALKIASCLESSPVTEVFICYNDIGKDGCDGLAGVVNLSQSLQVLDIRGNRLCASDVHRLLRSVSMSTVLTRLGLASNKLGPEGAALVAKALEHNTYLSSLDLSVNELGASGAEHIASILRNPVSALQVLQLHGNYLGSDGVITVCDAAKTNKELKRLTLGGNHATDEAACAVAAMLEANCMLEELDIRLNTLTAGGVQTIAQRGLANNTSLRVLSLAGNEVGPQGANELTNVLVTHQRSALEQLDLSSCGLSTSGGARIASLLSTSISLKEVNLSDNALDDEAAVRLAQNMAEGISISVVDVSCNEIGEEGASQLIEAVLRNAQLVALVTNGNNISRVAQRKIENLLEERLSKNRVLSRHAALFQQQKLGQQQQAVRSTAAPAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KP83</accession>
    <name>A0A836KP83_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000020">
        <property type="protein sequence ID" value="KAG5480412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063743.1">
        <property type="nucleotide sequence ID" value="XM_067208103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KP83"/>
    <dbReference type="GeneID" id="92362037"/>
    <dbReference type="KEGG" id="loi:92362037"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5480412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="318" mass="34373" checksum="0BBCE618B82C7605" modified="2021-09-29" version="1">MSMNASGETLMEPLAAPCRAGGVEGSGAPVVSANANGAAQKLISRSPKDPSQSSTHPLPALRRPLNGEWYGISLPQQPHLHPGNALRTATPHMMRKTGGTGGPPMMPHLPAPPGGPDCCASPRPAPPRMQRCGPPLHASLTTSSRNTGPIDWSAISGSSGPWNRCQLPSQVPRSELIMSVARGPQPTSVEPTRLMNGKKIKDVERRHQASETQRKHNFTGPAKAAVGQHKGGQKPQRQDANSRKIKTTVGGDDSWMKGLTYSTWVDSPKGLSSDVEREGPYKRRPRSRKKNRENRKSVSRDHMGKSSLLMEALRNLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KPZ7</accession>
    <name>A0A836KPZ7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable methyltransferase BMT2 homolog</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_04753</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Probable S-adenosyl-L-methionine-dependent methyltransferase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the BMT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="JAFHLR010000023">
        <property type="protein sequence ID" value="KAG5478520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063181.1">
        <property type="nucleotide sequence ID" value="XM_067206734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KPZ7"/>
    <dbReference type="GeneID" id="92360668"/>
    <dbReference type="KEGG" id="loi:92360668"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03044">
        <property type="entry name" value="BMT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021867">
        <property type="entry name" value="Bmt2/SAMTOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21008:SF0">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SENSOR UPSTREAM OF MTORC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21008">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SENSOR UPSTREAM OF MTORC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="140"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="320"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="335"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="436"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5478520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="672" mass="71791" checksum="9745B88CD6C26106" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KRL7</accession>
    <name>A0A836KRL7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA/RNA-binding protein Alba-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_07877</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000013">
        <property type="protein sequence ID" value="KAG5484311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064804.1">
        <property type="nucleotide sequence ID" value="XM_067209754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KRL7"/>
    <dbReference type="SMR" id="A0A836KRL7"/>
    <dbReference type="GeneID" id="92363688"/>
    <dbReference type="KEGG" id="loi:92363688"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.110.20:FF:000005">
        <property type="entry name" value="Uncharacterized protein At2g34160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.20">
        <property type="entry name" value="Alba-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036882">
        <property type="entry name" value="Alba-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002775">
        <property type="entry name" value="DNA/RNA-bd_Alba-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014560">
        <property type="entry name" value="UCP030333_Alba"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31947">
        <property type="entry name" value="DNA/RNA-BINDING PROTEIN ALBA 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31947:SF36">
        <property type="entry name" value="DNA_RNA-BINDING PROTEIN ALBA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01918">
        <property type="entry name" value="Alba"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF030333">
        <property type="entry name" value="UCP030333_Alba"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82704">
        <property type="entry name" value="AlbA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/RNA-binding protein Alba-like" evidence="2">
        <location>
            <begin position="10"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5484311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="121" mass="13469" checksum="5D7D91CB621550EC" modified="2021-09-29" version="1">MANENGENAIVRVSSNKRKFGYVDYAKHRLHEGYPEVTISALGTAIADAVSVVELLKNQGVVEVKRIRTARAHFDDVRSTTTDKIEVTLTKSADFDAIYEQQQRDREAAKARTEGEEAGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KRP4</accession>
    <name>A0A836KRP4_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_04333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="protein sequence ID" value="KAG5475748.1"/>
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            <begin position="116"/>
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            <begin position="10"/>
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    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5475748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="137" mass="15400" checksum="BA675519570FDA97" modified="2021-09-29" version="1">MPAKRAAAKRPAEAPLHRSDADGPSSMQHPPATAATSSSNPLPATALEEVAPKVIMSKAQRRKLKKPPVVVTAEMKERAREETRELRKYLRMVKSNGARRKVAKLHAKRPREYNLNEEAANAFDTDYRPHKKGRRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">DUF4110 domain-containing protein</fullName>
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        <name evidence="3" type="ORF">LSCM4_05538</name>
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        <name type="scientific">Leishmania orientalis</name>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000016">
        <property type="protein sequence ID" value="KAG5482285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="entry name" value="Kelch_domain_protein"/>
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        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF4110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
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    </dbReference>
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        <property type="entry name" value="Kelch motif"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="708"/>
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    </feature>
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        <location>
            <begin position="1"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="537"/>
            <end position="572"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="17"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
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        <location>
            <begin position="405"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="563"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5482285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="727" mass="82177" checksum="AAC294221533B903" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KWE0</accession>
    <name>A0A836KWE0_9TRYP</name>
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        <recommendedName>
            <fullName evidence="11">Nop14-like family protein</fullName>
        </recommendedName>
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        <name evidence="9" type="ORF">LSCM4_08192</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
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            <taxon>Leishmania</taxon>
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    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000002">
        <property type="protein sequence ID" value="KAG5488212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067210062.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030692">
        <property type="term" value="C:Noc4p-Nop14p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007276">
        <property type="entry name" value="Nop14"/>
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        <property type="entry name" value="NOP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23183:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04147">
        <property type="entry name" value="Nop14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
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        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="458"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="888"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="189"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="473"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5488212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="924" mass="101238" checksum="1FE049F30CC78DE4" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KWN9</accession>
    <name>A0A836KWN9_9TRYP</name>
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        <recommendedName>
            <fullName evidence="11">Folate/biopterin transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_06586</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Folate-biopterin transporter (TC 2.A.71) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000010">
        <property type="protein sequence ID" value="KAG5485630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065214.1">
        <property type="nucleotide sequence ID" value="XM_067208503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KWN9"/>
    <dbReference type="GeneID" id="92362437"/>
    <dbReference type="KEGG" id="loi:92362437"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039309">
        <property type="entry name" value="BT1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
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        <property type="entry name" value="fbt"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FOLATE-BIOPTERIN TRANSPORTER 1, CHLOROPLASTIC"/>
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    </dbReference>
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        <property type="entry name" value="TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BT1"/>
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    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-0813">Transport</keyword>
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            <begin position="114"/>
            <end position="133"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="158"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
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        <source>
            <dbReference type="EMBL" id="KAG5485630.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="702" mass="76704" checksum="ACF77AB097E9A419" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KWP3</accession>
    <name>A0A836KWP3_9TRYP</name>
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        <recommendedName>
            <fullName evidence="1">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">LSCM4_06602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
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        <lineage>
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            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG5485645.1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="27"/>
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        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5485645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="371" mass="40045" checksum="0E94D1838C4BEB46" modified="2021-09-29" version="1">MNGKAGTQVAPVKCKGWCVEKPASQWSTDAVKLSNVMIPAPGPTQIRVKVYAASINPIDWKRVMFPASNFRPGVAASNLPGFKGMHHRPPNYPWPYVVGVDGAGEVESVGEKVTELKAGDRVMFHSSLTSACGGSLCEYAVMEDSVAVPIPAGEARAFSYEEAAAIPCATWTAYVALFDKLRIEQGRSIFVDGASGAVGSSAVQLAHNMGLYVFASCSPSNADYVRSIGADQVLNYHDGLAMVDQILDATEGYGVDYYLAVTNMQDAENFTDVLRFGGAVCVLSGVLIPESEVLFRRQLSVHHVFLNGLHDHPLTRPQLRYIGDQVTKLYLNDAFRLDVEVVPFAEAAKALDRSATGNVHHKKLVVRVASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KWR3</accession>
    <name>A0A836KWR3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Receptor ligand binding region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_06447</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000019">
        <property type="protein sequence ID" value="KAG5480878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063879.1">
        <property type="nucleotide sequence ID" value="XM_067208367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KWR3"/>
    <dbReference type="SMR" id="A0A836KWR3"/>
    <dbReference type="GeneID" id="92362301"/>
    <dbReference type="KEGG" id="loi:92362301"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050726">
        <property type="entry name" value="mGluR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24060">
        <property type="entry name" value="METABOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="894"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="domain" description="Receptor ligand binding region" evidence="7">
        <location>
            <begin position="121"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Receptor ligand binding region" evidence="7">
        <location>
            <begin position="513"/>
            <end position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5480878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="949" mass="102447" checksum="30558A7F34F7B2AE" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KXT4</accession>
    <name>A0A836KXT4_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
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                <person name="Al-Salem W.S."/>
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                <person name="Bates M.D."/>
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</entry>
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            <dbReference type="Google" id="ProtNLM"/>
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    <sequence length="172" mass="20027" checksum="427E6278671F570E" modified="2021-09-29" version="1">MAPKKPNDEALLDACINANRLEYPEQSLIFVALIASFQPVYFSHAINGLDWRHMPNLVLYFIITGFTTYMLRQAYVVMVQSEFWGRQRHFAEVSDEKSKALRRLRLQVAVGYSLFFLNSVFFGVSTCLMAYIFRHSDPRASYILSPTLTAALLWLVAQKNEESRQRRMRLHK</sequence>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
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                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466422.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
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    </evidence>
    <sequence length="289" mass="31475" checksum="967D0FE690A851E6" modified="2021-09-29" version="1">MAYFHTKYGVQHGDEANDKALREYFFPDKDTCQRVLIGYDLMAKSVSALLMYSPSVPPTFIGNQTVRNVPCGVWVAEVNGFRVTWYWETSRHVDTTPFHTPGSVRSGASAYPKLMRMTVEGQGGAPPLFPHHPFFPQGYAFPLADRSMACGVLGPGEGSIGCNENHDDDYILIYDVTSFVPYVRREDYTIPKACNGTMISGSIPSVLCRYNGITGSVAAALLVVVALLFALVSGCCVWCPFSRMVRHQQDELARLTWEIHLAEGGNGTDGQDTAILGATGGGDVKNSSS</sequence>
</entry>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
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</entry>
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    <accession>A0A836G7K0</accession>
    <name>A0A836G7K0_9TRYP</name>
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        <recommendedName>
            <fullName evidence="8">DM10 domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="9" type="ORF">LSCM4_01025</name>
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        <name type="scientific">Leishmania orientalis</name>
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        <lineage>
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    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467939.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A836G7K0"/>
    <dbReference type="SMR" id="A0A836G7K0"/>
    <dbReference type="GeneID" id="92357025"/>
    <dbReference type="KEGG" id="loi:92357025"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005879">
        <property type="term" value="C:axonemal microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04412">
        <property type="entry name" value="NDPk7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006602">
        <property type="entry name" value="DM10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037993">
        <property type="entry name" value="NDPk7B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43109">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43109:SF2">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00676">
        <property type="entry name" value="DM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51336">
        <property type="entry name" value="DM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DM10" evidence="8">
        <location>
            <begin position="6"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5467939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="343" mass="37398" checksum="CF0997EED524B159" modified="2021-09-29" version="1">MATSTLDPRMAFHAQQQDPGAPQPRQLILRYFYQSGTVELMEVPSGRLYLKRTAIDLPASAFTVGSTVMLFGKATAITAFADEVTRQLCAQCSETTTVLIAEEAFSSLGRYLAMLTEECRFTISELEMVWVQAETVSAFDLPEQLTNTRLVVVICTRNQAVEKGFDFVLRATGTCTAKDAEQAATWGKLSELAKAKPLAVYEEPNSSVVVLKPHLVSTGRGGSALQQLLDEGLEVTALTTVTMSSAAAGEFMEPYRGVLPNLEGTVNSFVGTSWVLQLVSLDEGAKVLEIVRSSCGPYDTVIAKKLYPKSIRARYGESDTNNAVHCCDLPGDGPIYTKFFFQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G8V8</accession>
    <name>A0A836G8V8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glucosamine-6-phosphate isomerase</fullName>
            <ecNumber evidence="6">3.5.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Glucosamine-6-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_03021</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the reversible conversion of alpha-D-glucosamine 6-phosphate (GlcN-6P) into beta-D-fructose 6-phosphate (Fru-6P) and ammonium ion, a regulatory reaction step in de novo uridine diphosphate-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc) biosynthesis via hexosamine pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>alpha-D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12172"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:75989"/>
            <dbReference type="EC" id="3.5.99.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.99.6" evidence="6"/>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060592.1">
        <property type="nucleotide sequence ID" value="XM_067205040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G8V8"/>
    <dbReference type="SMR" id="A0A836G8V8"/>
    <dbReference type="GeneID" id="92358974"/>
    <dbReference type="KEGG" id="loi:92358974"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004342">
        <property type="term" value="F:glucosamine-6-phosphate deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006043">
        <property type="term" value="P:glucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006046">
        <property type="term" value="P:N-acetylglucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019262">
        <property type="term" value="P:N-acetylneuraminate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01399">
        <property type="entry name" value="GlcN6P_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000002">
        <property type="entry name" value="Glucosamine-6-phosphate deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01241">
        <property type="entry name" value="GlcN6P_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004547">
        <property type="entry name" value="Glucosamine6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018321">
        <property type="entry name" value="Glucosamine6P_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00502">
        <property type="entry name" value="nagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280">
        <property type="entry name" value="GLUCOSAMINE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280:SF5">
        <property type="entry name" value="GLUCOSAMINE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01161">
        <property type="entry name" value="GLC_GALNAC_ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="7">
        <location>
            <begin position="8"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5470326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="279" mass="31308" checksum="C588B71CE93F0E80" modified="2021-09-29" version="1">MRIVISETADQVADYASKYVIKSINDFKPSADRPFVLGLPTGETPMRTYQKLILAYREGRVSFKNVVTFNMDEYVGLPADHPESYHYFMKHNFFNYVDLPEKNRHILNGNAPDLEEECRQYEEKIRSVGGIHLFLAGIGTDGHLAFNEPGSSLYSRTRVKSLNAETMESNARFFGNDVSRVPSMALTVGLRTIMEAKVVLMIATGTGKALAVARCVEGGITHMCTATMLQMHPAAVLCLDEDATLELKVRTTRYFKALRSTEKALEERQANMRRVAAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GCH2</accession>
    <name>A0A836GCH2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_00020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 5"/>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058213.1">
        <property type="nucleotide sequence ID" value="XM_067202112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GCH2"/>
    <dbReference type="SMR" id="A0A836GCH2"/>
    <dbReference type="GeneID" id="92356046"/>
    <dbReference type="KEGG" id="loi:92356046"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000047">
        <property type="entry name" value="Peptidylprolyl isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050689">
        <property type="entry name" value="FKBP-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10516:SF443">
        <property type="entry name" value="FK506-BINDING PROTEIN 59-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10516">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
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        <location>
            <begin position="21"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5464582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="111" mass="12218" checksum="E62009AD9CF695F2" modified="2021-09-29" version="1">MQMGVMRTVKKAGSGAMPKAGQTITLHCTGYLADGKTKFWSTRDDNKPFSFNVGIGQVIRGWDEGVMQMQLGETAELLMTADYAYGARGFPAWNIPPNASLLFEIELLKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GCJ4</accession>
    <name>A0A836GCJ4_9TRYP</name>
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        <recommendedName>
            <fullName evidence="5">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">LSCM4_00067</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
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            <taxon>Eukaryota</taxon>
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            <taxon>Euglenozoa</taxon>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058258.1">
        <property type="nucleotide sequence ID" value="XM_067202157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GCJ4"/>
    <dbReference type="GeneID" id="92356091"/>
    <dbReference type="KEGG" id="loi:92356091"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146:SF0">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032709834" description="EamA domain-containing protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="272"/>
        </location>
    </feature>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5464627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="460" mass="50502" checksum="2666A08AAA0DEBA2" modified="2021-09-29" version="1">MGDAASALFLVVLAVLYLSWGTVQTLSLKWADTIAASDGFTGPTIGSGGSHPVHFRLLYSFAHPFTQALFMFCAETSCLLVFVCTLAWKKYAAPRLHRSRKVGDAPTGALVAGEDYALPCNLALWMLPSGADLLASIIQNIGMMLTHASVYQMLRGATVVWIAIISYFWLGRCFSKVELWGMGCAVLGLSCVGLSSFLESGTGFSALSEGRHSYQALGNILVLVAQILHAYQGVCEERMIRLYKIPPMQMVGTEGIYGVGMTLSLLAFLQLVPMADWGHNLAAVEEFPALGGPGVIYTNVTWVRQLQPELKVPYDDVVLAFSQISQSWMCKLFILVYVPAGFFFNACEMSMIKYVSATATVMLGSLRNVTVWLVCLLIPSVFEEHFNLLQFIGFVFLVLGNVLFHRLCFTHFDAILPARVMDACPLLFRDAKRDRAPVVESRSSDILPEPLSGVIRCKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GCX3</accession>
    <name>A0A836GCX3_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Discoba</taxon>
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            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061047.1">
        <property type="nucleotide sequence ID" value="XM_067204010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GCX3"/>
    <dbReference type="SMR" id="A0A836GCX3"/>
    <dbReference type="GeneID" id="92357944"/>
    <dbReference type="KEGG" id="loi:92357944"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <end position="335"/>
        </location>
    </feature>
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        <location>
            <begin position="352"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5472651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="472" mass="50677" checksum="1EB1BD938CDFF9FE" modified="2021-09-29" version="1">MSFLRPTVSSLRRAVSGAPEERDRHGGPPTTVGVTPQAAQPISRDVVTSDYSHVSSRVDSGLRSRVRTSSLTRRTAAAAVSRSPSLREFADKCDSVIQRAQEMLERTREQELKVAKALEERKSKSPVSQATPPPPTESTPQRTPTSMHGGLASLTSSPAMPNAPYTTPVALTKAASSTPIPTSASLPSLPAPPPTPAGLPRSPLPTQPGTNTSPSGPVGRSSPTSLLQRIRQSWQRVPGQSGETYTPSPTPSAPDGVLCTGVTRVSPRKSVRFASPDKLETVTPTRVVALSSDDEGSDEEDEETSEDEEEQDWLPPSKKMRAESSSDSHTPHRDSVAVPPAPPPSAIKPDSRSSSESSGSVSSSASSPPSRGTVSPSPSHRQRSVSNRGRSSSERSSTSSSRPSMDHGAVKEYVAHHTIRRSLSRISRADMEDYLREEGVALPADGHWLKRQLLAHIRAFIKQDMARHRHQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GD56</accession>
    <name>A0A836GD56_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_05795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063498.1">
        <property type="nucleotide sequence ID" value="XM_067207725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GD56"/>
    <dbReference type="GeneID" id="92361659"/>
    <dbReference type="KEGG" id="loi:92361659"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5479787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="722" mass="78921" checksum="87D9CA7DF4A62A74" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GDX9</accession>
    <name>A0A836GDX9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_03271</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060836.1">
        <property type="nucleotide sequence ID" value="XM_067205284.1"/>
    </dbReference>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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    </feature>
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        <source>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Jariyapan N."/>
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                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG5465195.1"/>
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        <property type="evidence" value="ECO:0007669"/>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
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    </evidence>
    <sequence length="434" mass="50211" checksum="2C881FB891B8E796" modified="2021-09-29" version="1">MKAAKASTPVIAANASVSVTTLKAGTVILPHAEEVGLRRGLSPATITSTTGRLNHIAATNSSEENEEIVSHNVDDGRHGAVESPETSSKQRRTHALSTQGVNAAKEDHRSPYEHHDMFGFRVTEEEKAAEDHERRNSQDSREYLEKWQYIITNWDNVTPKKVKKYCRRGVPQSLRCIVWQQLLQSRQMKEQYPGLYMRLRSQPLSSRDLEDVIERDLHRTFPTNRLFCAGESSQGQQILRSILRAYANYNTDVGYCQGMGFLAATFILQVEEEEDAFWAFVALMEKEKYNMKAIFVPNFPQLQCMFYVFEALMQQKIPKLYAQLHDRHQIQPYFYAVHWFMTVFTYYFNFGLASRIWDMFLCEGWKPVYRIALALLKIEEQRLLSLKTETELLMALKSLQESKRPAQLLRIALKMNFKTAYVKALVSQYHAQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GHT9</accession>
    <name>A0A836GHT9_9TRYP</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="scientific">Leishmania orientalis</name>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
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            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5467912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="551" mass="59263" checksum="1059535D6B04B569" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GI57</accession>
    <name>A0A836GI57_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_01949</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
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        <name evidence="2" type="ORF">LSCM4_00515</name>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
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            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
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<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="16" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
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            <dbReference type="ChEBI" id="CHEBI:30013"/>
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            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
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    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
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        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PPP phosphatase family. PP-2B subfamily.</text>
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    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="EMBL" id="JAFHLR010000026">
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0033192">
        <property type="term" value="F:calmodulin-dependent protein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097720">
        <property type="term" value="P:calcineurin-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07416">
        <property type="entry name" value="MPP_PP2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041751">
        <property type="entry name" value="MPP_PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043360">
        <property type="entry name" value="PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45673">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="14">
        <location>
            <begin position="182"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="469"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="473"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG5476279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="498" mass="55644" checksum="7D8B721834A5A8A7" modified="2021-09-29" version="1">MPLTAQSSVFEASATAFFTGIDDGEKKRREMAFRSSSSSAGLVERMLLTERGDPSVPPPNWEPLSSSAVFDENGMTRPNVVREHFQKEGLLHESDVLAIITKCALIWKDEPNVLLLDDPVNIAGDIHGQFYDLLNLFSIGGDPSHQKYVFLGDYVDRGCFGMEVILLLMCYKICYPSTFVMLRGNHESRHLTAYFNFKREVLYKYSIAVYNAMMAAFDCLPLACIVNNRFLCVHGGLSPELKRISDISAIHRFREPPSSGPMCDLLWADPLDENEEDPAAPQLFVPNTTRGCSYVYSSAAACNFLQENDLVTIIRGHEAQNDGYHLYKKTRKGFPAVICVFSAPNYCDTYDNRAAMVMLSRNIMSIRQFNSSPHPYYLPNFMNAFTWSLPFVEEKLLDIWTNVLHLVDVDEDQFLANKAEVSVAVATDAPAQWVSTESSSGSPLVRQHESIRQKILAMGTLSRMLRDLREGNESNSRLTGQVSGLPSEDVRPPGASGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GM75</accession>
    <name>A0A836GM75_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_02977</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060548.1">
        <property type="nucleotide sequence ID" value="XM_067204996.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92358930"/>
    <dbReference type="KEGG" id="loi:92358930"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006615">
        <property type="entry name" value="Pept_C19_DUSP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF23">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE USP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00695">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51283">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUSP" evidence="3">
        <location>
            <begin position="323"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="2">
        <location>
            <begin position="623"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5470282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1338" mass="148064" checksum="0B64E8D6D40B59FC" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GMT7</accession>
    <name>A0A836GMT7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_05404</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the phage and mitochondrial RNA polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2"/>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5478006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062913.1">
        <property type="nucleotide sequence ID" value="XM_067207345.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836GMT7"/>
    <dbReference type="GeneID" id="92361279"/>
    <dbReference type="KEGG" id="loi:92361279"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034245">
        <property type="term" value="C:mitochondrial DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006390">
        <property type="term" value="P:mitochondrial transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.280:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000082">
        <property type="entry name" value="DNA-directed RNA polymerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046950">
        <property type="entry name" value="DNA-dir_Rpol_C_phage-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002092">
        <property type="entry name" value="DNA-dir_Rpol_phage-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10102">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10102:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00940">
        <property type="entry name" value="RNA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00489">
        <property type="entry name" value="RNA_POL_PHAGE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
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            <end position="1504"/>
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        <location>
            <begin position="1097"/>
            <end position="1475"/>
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    </feature>
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        <location>
            <begin position="127"/>
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        <location>
            <begin position="204"/>
            <end position="232"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="250"/>
            <end position="271"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00940"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5478006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1504" mass="165916" checksum="4C9D80356116E91F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="92361048"/>
    <dbReference type="KEGG" id="loi:92361048"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5476184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="578" mass="63317" checksum="C94EA0F84AEA9579" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GQV9</accession>
    <name>A0A836GQV9_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="160"/>
            <end position="240"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
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            <dbReference type="EMBL" id="KAG5470145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="256" mass="26880" checksum="2ACCF709964E5B5E" modified="2021-09-29" version="1">MALLLDDDEVLVATVTASREPGHVPSLAPAHDLLAADRDARVNESLSPCATASSCRAREHAPSTAAAAPHGECSAVSACITVTMPREGGNGMKKMEALLFGKSKVALVCDGTVPCRKRFADEAFGTAVEPKHVLQKTSLAPACDGSTDSTCTQPKVVSAARSLSSASLQREKPSTPSWETMPLTPHERSSHVAVSTSPEHQVGSPAASPPARRPPTHSSMAREETAAEIPASPATKEPAKMQMKLSDFFSKMACKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836GS05_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="3" type="ORF">LSCM4_05285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5477894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067207233.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="loi:92361167"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032745253" evidence="2">
        <location>
            <begin position="19"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5477894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="166" mass="18130" checksum="C353A03461BA9B51" modified="2021-09-29" version="1">MRALCLRSLACVPTGVAARCYGGQGSARPPTGGRYSRGGGPLYQDLRNVPTEPQIVARLIKCFPCTKTFVPISKWAAALPDDLREILVPYGGLGAFASAQSNFFMIRKENGVTVASLSAMGTELAMEHERKEKQEQKRAEKFNQRRDSFAPRGRGFSPARGGLPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GS67</accession>
    <name>A0A836GS67_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NF-kappa-B-activating protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_02371</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NKAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5468978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059955.1">
        <property type="nucleotide sequence ID" value="XM_067204403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GS67"/>
    <dbReference type="SMR" id="A0A836GS67"/>
    <dbReference type="GeneID" id="92358337"/>
    <dbReference type="KEGG" id="loi:92358337"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040466">
        <property type="entry name" value="NKAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009269">
        <property type="entry name" value="NKAP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13087">
        <property type="entry name" value="NF-KAPPA B ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13087:SF0">
        <property type="entry name" value="NFKB ACTIVATING PROTEIN LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06047">
        <property type="entry name" value="Nkap_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NF-kappa-B-activating protein C-terminal" evidence="3">
        <location>
            <begin position="311"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="115"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="290"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5468978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="400" mass="43459" checksum="581E2CFD02D16689" modified="2021-09-29" version="1">MSKSIWALAPPTTSPADFPSGEEMEQMMCRSLEENAYSAQGFWIWQSNFIQLRRRREQRRRRLRDDAAAPAGDGIGDSASARSETEAMSLKRAGEIREYVSAVLHATGYPYRSASAEDVGEGADDSVQATEADAETPVTSAGLTSASFSPVVADPIGVSGEPPRKVSRGEETDSAARTPAVPKSALAKLVAKARAQHRDLVEHAPVVVVPLPVRRDQPEETGSQPGVERKRIQFADDSPLANNWQPLRVNPIRGDDGDGDDDFTIHFPGHTGPLASAGIDKLDGRSPHSAAGAAGGTDAVAAKHPSQMTRAEFLSQFKRAPRRGEVGQTAEKIAAAEKLGYVMSGSRSVASRMYVDRIQRQLHEHEAAKLQQQFRKVEDERMDDQLVLELAQFINGRKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GTH6</accession>
    <name>A0A836GTH6_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060687.1">
        <property type="nucleotide sequence ID" value="XM_067205135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GTH6"/>
    <dbReference type="SMR" id="A0A836GTH6"/>
    <dbReference type="GeneID" id="92359069"/>
    <dbReference type="KEGG" id="loi:92359069"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5471570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="307" mass="33033" checksum="576450A50BCCA509" modified="2021-09-29" version="1">MRPFPSLRCTSLRTPALDRGRTFAAPFKAASLEGAHSCLPDAGGEAAKFRQLKDGCDALRSRSGRLAASAGLTETHRAGHTGASNRGASGGKRAHILEERCNVGEGRGSVLASTWDYGAGTQYANESTRNFYRAYSANYCDPRSTGFTREEVAYAERATRLRMLKGIGWKCLVYGSALYLLLEYWRDRGASTMQSSNALSCAQWEKAGQRHQLRQTQPKPSPSRTELLTTRHLTDRDTSSQDGPLAVVDGRAALSPAPSSLSTAQSGISLPASAPSCAQPSAFSVTVSRNGIDLDMSDEDDDDNDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GU39</accession>
    <name>A0A836GU39_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_08150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000002">
        <property type="protein sequence ID" value="KAG5488172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066220.1">
        <property type="nucleotide sequence ID" value="XM_067210022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GU39"/>
    <dbReference type="GeneID" id="92363956"/>
    <dbReference type="KEGG" id="loi:92363956"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021067">
        <property type="entry name" value="Glycosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34496">
        <property type="entry name" value="GLCNAC TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34496:SF7">
        <property type="entry name" value="GLYCOSYLTRANSFERASE (GLCNAC)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5488172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1125" mass="121851" checksum="22736F7CFB3DA9B7" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GUB9</accession>
    <name>A0A836GUB9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="3">PPIase</shortName>
            <ecNumber evidence="3">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_00336</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 3">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3"/>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058521.1">
        <property type="nucleotide sequence ID" value="XM_067202420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GUB9"/>
    <dbReference type="SMR" id="A0A836GUB9"/>
    <dbReference type="GeneID" id="92356354"/>
    <dbReference type="KEGG" id="loi:92356354"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097014">
        <property type="term" value="C:ciliary plasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000067">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF488">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="4">
        <location>
            <begin position="17"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5464890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="200" mass="21549" checksum="41B79F8670BCAEE0" modified="2021-09-29" version="1">MFAQCAIRWAAAVGHAFMDIAIGSQPPRRVTFELFSKRCPVASDNFLKLCTGENVLPRMSSIDGIIEPSFRDQFLPQLTYRNTTVHRVCKGYLVQGGDIVSGQGTGQLSIYGESFDAPEEVKASKFDQKGLLGTAVSAPHLNGSQFFILTADKAPHLNGTCICFGRVVDGWAVVTAIETVPLTAAGEPAERIVVVECGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GUG0</accession>
    <name>A0A836GUG0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dephospho-CoA kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_01896</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">LSCM4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoaE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000022">
        <property type="protein sequence ID" value="KAG5479304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063397.1">
        <property type="nucleotide sequence ID" value="XM_067203938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GUG0"/>
    <dbReference type="SMR" id="A0A836GUG0"/>
    <dbReference type="GeneID" id="92357872"/>
    <dbReference type="KEGG" id="loi:92357872"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02022">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000991">
        <property type="entry name" value="Dephospho-CoA kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00376">
        <property type="entry name" value="Dephospho_CoA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00152">
        <property type="entry name" value="dephospho-CoA kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695:SF46">
        <property type="entry name" value="BIFUNCTIONAL COENZYME A SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695">
        <property type="entry name" value="DEPHOSPHO-COA KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-0418">Kinase</keyword>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5479304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="244" mass="27260" checksum="4C1529291A2CCEFE" modified="2021-09-29" version="1">MILIGLTGGIACGKSCVSRILEEEFHIEVIDADRIVRDLQAPNAACTRLIAARWPLCVHLETGELNRAALGKAIFSDPQARRELQKIMNPAIFRAILKRVAAAWWRNLWRSGAALSPSIVVLDAPTLFETKTLTYLISASVVVSCSEERQIERLRRRNGFSKEEALQRIRSQMALEAKRRLADYIIDNDYAEDFEALRRSLRACVSWMSCQSDKRLTFIFGTVSAAAVALAAVMGYVGYQVLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GUS6</accession>
    <name>A0A836GUS6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab3-GAP regulatory subunit N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_00613</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058791.1">
        <property type="nucleotide sequence ID" value="XM_067202690.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92356624"/>
    <dbReference type="KEGG" id="loi:92356624"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026059">
        <property type="entry name" value="Rab3GAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032839">
        <property type="entry name" value="RAB3GAP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12472:SF0">
        <property type="entry name" value="RAB3 GTPASE-ACTIVATING PROTEIN NON-CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12472">
        <property type="entry name" value="RAB3-GAP REGULATORY DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14655">
        <property type="entry name" value="RAB3GAP2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab3-GAP regulatory subunit N-terminal" evidence="2">
        <location>
            <begin position="420"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1632"/>
            <end position="1655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1632"/>
            <end position="1644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5465160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1744" mass="187674" checksum="AE950802EE019112" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GVA3</accession>
    <name>A0A836GVA3_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_00229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058419.1">
        <property type="nucleotide sequence ID" value="XM_067202318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GVA3"/>
    <dbReference type="SMR" id="A0A836GVA3"/>
    <dbReference type="GeneID" id="92356252"/>
    <dbReference type="KEGG" id="loi:92356252"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="625"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="681"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="747"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="838"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="312"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="683"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="701"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5464788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="919" mass="97724" checksum="6211A98894FCD8A4" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GW39</accession>
    <name>A0A836GW39_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ARMET C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_01293</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059041.1">
        <property type="nucleotide sequence ID" value="XM_067203350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GW39"/>
    <dbReference type="SMR" id="A0A836GW39"/>
    <dbReference type="GeneID" id="92357284"/>
    <dbReference type="KEGG" id="loi:92357284"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019345">
        <property type="entry name" value="ARMET_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10208">
        <property type="entry name" value="ARMET_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033049268" description="ARMET C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="ARMET C-terminal" evidence="2">
        <location>
            <begin position="25"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5466151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="219" mass="24555" checksum="C2F285546AC7363B" modified="2021-09-29" version="1">MKLFRAAVLITVLAVTLVSATMTESDFKRMKVKDLRAFLLDRGLECAGCQEKSDFVRMAYQHRDKNPVGTAKKREIPNKKFWEAWSDIAKKECEQAVKRRGNDATAEPFSTICDTIYSAADSYLMEHGRRVANQLKKTPQHLLKTSFKDVYFEAGCHLFRTLADYCLASPSSQKACQSLGSVMSAMDGSSGADFKMWTTNVGIENTNPMYDIIGEHGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GWJ4</accession>
    <name>A0A836GWJ4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_01247</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058995.1">
        <property type="nucleotide sequence ID" value="XM_067203304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GWJ4"/>
    <dbReference type="GeneID" id="92357238"/>
    <dbReference type="KEGG" id="loi:92357238"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF279">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="286"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5466105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="732" mass="81111" checksum="3A7BF00F2CA10E2A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GWL2</accession>
    <name>A0A836GWL2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4456 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_06241</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000020">
        <property type="protein sequence ID" value="KAG5480474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063805.1">
        <property type="nucleotide sequence ID" value="XM_067208165.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836GWL2"/>
    <dbReference type="GeneID" id="92362099"/>
    <dbReference type="KEGG" id="loi:92362099"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027914">
        <property type="entry name" value="DUF4456"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21444">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21444:SF14">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14644">
        <property type="entry name" value="DUF4456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4456" evidence="3">
        <location>
            <begin position="1253"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="632"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1465"/>
            <end position="1492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1558"/>
            <end position="1595"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="970"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="632"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1465"/>
            <end position="1477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1479"/>
            <end position="1492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1573"/>
            <end position="1584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5480474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1670" mass="182082" checksum="5AB2FFCF0DF26D32" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H0I0</accession>
    <name>A0A836H0I0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Prefoldin subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_04430</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">LSCM4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062623.1">
        <property type="nucleotide sequence ID" value="XM_067206414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H0I0"/>
    <dbReference type="SMR" id="A0A836H0I0"/>
    <dbReference type="GeneID" id="92360348"/>
    <dbReference type="KEGG" id="loi:92360348"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016661">
        <property type="entry name" value="PFDN4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100:SF9">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016477">
        <property type="entry name" value="Prefoldin_subunit_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="25"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR016477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5477212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="127" mass="14858" checksum="66A02FF7A309246A" modified="2021-09-29" version="1">MTTTANKNDVPVDVTWEDQRNICIFSRLHRRVQTLNRRLRLLRDDIEKLDDASTEVMICDDVKYVFGEAFVDVECDQAVDLLDAEKRRMESEKEEVEADLKDLDAALRELKAQLYAKFGSQIYLEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H182</accession>
    <name>A0A836H182_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leucine-rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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                <person name="Al-Salem W.S."/>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. MFSD6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469048.1"/>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="Pfam" id="PF12832"/>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="592" mass="64354" checksum="316CF725A04FBFA7" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="7">Nodulin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="8" type="ORF">LSCM4_06005</name>
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    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000011">
        <property type="protein sequence ID" value="KAG5485369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065106.1">
        <property type="nucleotide sequence ID" value="XM_067207932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H3X2"/>
    <dbReference type="GeneID" id="92361866"/>
    <dbReference type="KEGG" id="loi:92361866"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010658">
        <property type="entry name" value="Nodulin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576:SF157">
        <property type="entry name" value="NODULIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576">
        <property type="entry name" value="UNCHARACTERIZED NODULIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06813">
        <property type="entry name" value="Nodulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="447"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="481"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="508"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="540"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="579"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="Nodulin-like" evidence="7">
        <location>
            <begin position="42"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="310"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="637"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="644"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="656"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5485369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="673" mass="74502" checksum="8FFDC7965D059EAD" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H432</accession>
    <name>A0A836H432_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_07971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000013">
        <property type="protein sequence ID" value="KAG5484404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064897.1">
        <property type="nucleotide sequence ID" value="XM_067209847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H432"/>
    <dbReference type="SMR" id="A0A836H432"/>
    <dbReference type="GeneID" id="92363781"/>
    <dbReference type="KEGG" id="loi:92363781"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032:SF4">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="121"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="290"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5484404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="400" mass="45063" checksum="D4CA7A1E4D293134" modified="2021-09-29" version="1">MTEPMQTTPSFEYAKRAAMGSYWSNRDRDGKHFKNLGLAPSSRAPAGKVLRWLLSRTYYGIPKPEGGYDAFGKIWYAPCDMAESVAQWRASRDSDEGQPAKDRVYWIGHSSQLLCLANGINVLFDPIFSQRASPLSFAGPSRRYPPAATAAQLPPIHIVTVSHNHYDHMDKRSIKAIVVRFPDVQFVVPLKLDRFLREWGVPAASIITLDWYEACDVKGVRVGCTPAQHWGKHSAFDDNKVLWCGWCIGWQPGHQQLGSTNACPTLVPSSRTKSSAEVLEETRQTWSRYKKYFFTGDTAYNSDVSTSIYAHFGAMNMAALPIGAYSPRWFMARFHIDPEHAVKIFQDLHIQQAMAVHWGTFELADEPLDEPPKVLRDALKAARIDETTFQAIPMGGFIEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H5D5</accession>
    <name>A0A836H5D5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Intraflagellar transport protein 172</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_05830</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the IFT172 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063533.1">
        <property type="nucleotide sequence ID" value="XM_067207760.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836H5D5"/>
    <dbReference type="GeneID" id="92361694"/>
    <dbReference type="KEGG" id="loi:92361694"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000020">
        <property type="entry name" value="Intraflagellar transport protein 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000022">
        <property type="entry name" value="Intraflagellar transport protein 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001213">
        <property type="entry name" value="Intraflagellar transport protein 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056168">
        <property type="entry name" value="TPR_IF140/IFT172/WDR19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056157">
        <property type="entry name" value="TPR_IFT80_172_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15722">
        <property type="entry name" value="IFT140/172-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15722:SF2">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 172 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24762">
        <property type="entry name" value="TPR_IF140-IFT172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23387">
        <property type="entry name" value="TPR_IFT80_172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="IFT80/172/WDR35 TPR" evidence="10">
        <location>
            <begin position="671"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="domain" description="IF140/IFT172/WDR19 TPR" evidence="11">
        <location>
            <begin position="1034"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="453"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="457"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5479822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1800" mass="199979" checksum="6F0FAA16ED2B2D73" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H5G6</accession>
    <name>A0A836H5G6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA:m(4)X modification enzyme TRM13</fullName>
            <ecNumber evidence="1">2.1.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_05340</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine(4) in tRNA(His) + S-adenosyl-L-methionine = 2'-O-methyladenosine(4) in tRNA(His) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43196"/>
            <dbReference type="Rhea" id="RHEA-COMP:10401"/>
            <dbReference type="Rhea" id="RHEA-COMP:10402"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74477"/>
            <dbReference type="EC" id="2.1.1.225"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>cytidine(4) in tRNA(Gly)(GCC) + S-adenosyl-L-methionine = 2'-O-methylcytidine(4) in tRNA(Gly)(GCC) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43192"/>
            <dbReference type="Rhea" id="RHEA-COMP:10399"/>
            <dbReference type="Rhea" id="RHEA-COMP:10400"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.225"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>cytidine(4) in tRNA(Pro) + S-adenosyl-L-methionine = 2'-O-methylcytidine(4) in tRNA(Pro) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32767"/>
            <dbReference type="Rhea" id="RHEA-COMP:10397"/>
            <dbReference type="Rhea" id="RHEA-COMP:10398"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.225"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase TRM13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.225" evidence="1"/>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5477945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062852.1">
        <property type="nucleotide sequence ID" value="XM_067207284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H5G6"/>
    <dbReference type="GeneID" id="92361218"/>
    <dbReference type="KEGG" id="loi:92361218"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106050">
        <property type="term" value="F:tRNA 2'-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007871">
        <property type="entry name" value="Methyltransferase_TRM13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039044">
        <property type="entry name" value="Trm13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12998:SF1">
        <property type="entry name" value="TRNA:M(4)X MODIFICATION ENZYME TRM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12998">
        <property type="entry name" value="TRNA:M(4)X MODIFICATION ENZYME TRM13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05206">
        <property type="entry name" value="TRM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Methyltransferase TRM13" evidence="3">
        <location>
            <begin position="356"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="13"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5477945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="563" mass="62304" checksum="5597E538A337C368" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H5U5</accession>
    <name>A0A836H5U5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ERCC4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_07347</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">LSCM4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000008">
        <property type="protein sequence ID" value="KAG5486419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065485.1">
        <property type="nucleotide sequence ID" value="XM_067209242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H5U5"/>
    <dbReference type="SMR" id="A0A836H5U5"/>
    <dbReference type="GeneID" id="92363176"/>
    <dbReference type="KEGG" id="loi:92363176"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901255">
        <property type="term" value="P:nucleotide-excision repair involved in interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20078">
        <property type="entry name" value="XPF_nuclease_XPF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000002">
        <property type="entry name" value="DNA repair endonuclease XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000154">
        <property type="entry name" value="Putative DNA repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047520">
        <property type="entry name" value="XPF_nuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10150">
        <property type="entry name" value="DNA REPAIR ENDONUCLEASE XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10150:SF0">
        <property type="entry name" value="DNA REPAIR ENDONUCLEASE XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="11">
        <location>
            <begin position="1022"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="705"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="711"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5486419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1250" mass="134271" checksum="91817D1AA4A8D9E4" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H600</accession>
    <name>A0A836H600_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Translocon Sec61/SecY plug domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LSCM4_06046</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000011">
        <property type="protein sequence ID" value="KAG5485409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065146.1">
        <property type="nucleotide sequence ID" value="XM_067207972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H600"/>
    <dbReference type="SMR" id="A0A836H600"/>
    <dbReference type="GeneID" id="92361906"/>
    <dbReference type="KEGG" id="loi:92361906"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3370.10:FF:000009">
        <property type="entry name" value="Pretranslocation protein, alpha subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="entry name" value="SecY subunit domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019561">
        <property type="entry name" value="Translocon_Sec61/SecY_plug_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006341">
        <property type="entry name" value="PRK08568.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="SECY/SEC61-ALPHA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10559">
        <property type="entry name" value="Plug_translocon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="Preprotein translocase SecY subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00756">
        <property type="entry name" value="SECY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="286"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="424"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Translocon Sec61/SecY plug" evidence="12">
        <location>
            <begin position="42"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG5485409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="486" mass="54082" checksum="0CB7D8EC3C1DC7E2" modified="2021-09-29" version="1">MTKQANWLMSLKPMLAVLPEVEKPRRVPGIKERIMWTAVALFVFLICCQVPVYGARPGNTSDPFYWMRIVLASNKGTLMELGISPIVTASLILELLAGVRILTYDSNNREERAVFEGFQKMMGLVITVVEAVAYVSSGMYGDPSRIGVVMCGMIVLQLMAATMICMLLDELLQKGWGIGSGVSLFIATNVCDTVIWKSFSPSTINTGRGAEFEGAVIAFFHLLVSRTDKVRALREAFYRPQLPNLTNIFATAVVFVVVVFFQGFRVPLMTKNKYNGNDRQPYMIKLFYTSNMPIILQSSVVSNISFFSQILSRRFGNRNFLINLLGRWEERGYNGSGNGQLFPVGGLAYYLVPPATFYDLMADPIHAIFYVVFVLSSCAIFSRLWITISHTAPRDVAKQLASQGRWLVQARESEEDMTRLLEKYIPVAASFGGLCVGALTIFSDFLGAIGSGTGILLSVTMINQYYEVLQQEAQDLGYGFLKQKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H713</accession>
    <name>A0A836H713_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Calpain catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_03128</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060697.1">
        <property type="nucleotide sequence ID" value="XM_067205145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H713"/>
    <dbReference type="GeneID" id="92359079"/>
    <dbReference type="KEGG" id="loi:92359079"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015232">
        <property type="entry name" value="DUF1935"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036310">
        <property type="entry name" value="Smp-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47047:SF5">
        <property type="entry name" value="CYSTEINE PEPTIDASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47047">
        <property type="entry name" value="PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09149">
        <property type="entry name" value="DUF1935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101601">
        <property type="entry name" value="Smp-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="4">
        <location>
            <begin position="296"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="99"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="13"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5471580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="857" mass="94224" checksum="6761E1D06E2A1FBD" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H7D7</accession>
    <name>A0A836H7D7_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060877.1">
        <property type="nucleotide sequence ID" value="XM_067205325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H7D7"/>
    <dbReference type="GeneID" id="92359259"/>
    <dbReference type="KEGG" id="loi:92359259"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5471760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="546" mass="60368" checksum="934E1EB54EFAE425" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H7L2</accession>
    <name>A0A836H7L2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">YEATS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_07778</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Bates M.D."/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043634">
        <property type="term" value="P:polyadenylation-dependent ncRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000038">
        <property type="entry name" value="Topoisomerase-related function protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045862">
        <property type="entry name" value="Trf4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092">
        <property type="entry name" value="POLY(A) RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092:SF47">
        <property type="entry name" value="POLYMERASE SIGMA, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="2">
        <location>
            <begin position="405"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="721"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="835"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="851"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="876"/>
            <end position="899"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5486864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="916" mass="99385" checksum="BFE9AFC1A8F438F2" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H931</accession>
    <name>A0A836H931_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_06893</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000017">
        <property type="protein sequence ID" value="KAG5481817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064177.1">
        <property type="nucleotide sequence ID" value="XM_067208803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H931"/>
    <dbReference type="SMR" id="A0A836H931"/>
    <dbReference type="GeneID" id="92362737"/>
    <dbReference type="KEGG" id="loi:92362737"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06606">
        <property type="entry name" value="STKc_MAPKKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="873"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="391"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="137"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="393"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="418"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="475"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="901"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5481817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1189" mass="124592" checksum="E71B4EA705E0BBCD" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HA05</accession>
    <name>A0A836HA05_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_08029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000005">
        <property type="protein sequence ID" value="KAG5487584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065872.1">
        <property type="nucleotide sequence ID" value="XM_067209905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HA05"/>
    <dbReference type="GeneID" id="92363839"/>
    <dbReference type="KEGG" id="loi:92363839"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5487584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="97" mass="11225" checksum="AE12460C818BC371" modified="2021-09-29" version="1">MPRAYYKPFTAYEEAFGFHGTRRIAHIMCSVLFGGLLLKCVLLLKYSSVSNPKWTSPLEDDPRYQELMERRLVLAEDLSTQESMRRAMRARRSAPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HD42</accession>
    <name>A0A836HD42_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine incorporator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_03844</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TDE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061776.1">
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        </location>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Leishmania orientalis</name>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062124.1">
        <property type="nucleotide sequence ID" value="XM_067206187.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="92360121"/>
    <dbReference type="KEGG" id="loi:92360121"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5475616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="58" mass="6712" checksum="86666B26B03171AA" modified="2021-09-29" version="1">MQFVSMCSDEIRENQSWHSGAIIGRGSAYSSSHSAVYVTYLQYAAQHRTVCRWPDWWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
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                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
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        <location>
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            <end position="502"/>
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    </feature>
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        <location>
            <begin position="475"/>
            <end position="484"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5477176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="565" mass="60110" checksum="5ED4C071655316DE" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836HGW2_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
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            <taxon>Trypanosomatidae</taxon>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000009">
        <property type="protein sequence ID" value="KAG5485987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067208607.1"/>
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    <dbReference type="SMR" id="A0A836HGW2"/>
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    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="539"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5485987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="619" mass="69334" checksum="C7312A15CF41CE2A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HH23</accession>
    <name>A0A836HH23_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NFACT RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_06785</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NEMF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000009">
        <property type="protein sequence ID" value="KAG5486077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065408.1">
        <property type="nucleotide sequence ID" value="XM_067208697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HH23"/>
    <dbReference type="SMR" id="A0A836HH23"/>
    <dbReference type="GeneID" id="92362631"/>
    <dbReference type="KEGG" id="loi:92362631"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.310.10:FF:000001">
        <property type="entry name" value="Nuclear export mediator factor Nemf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.310.10">
        <property type="entry name" value="ibrinogen binding protein from staphylococcus aureus domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051608">
        <property type="entry name" value="RQC_Subunit_NEMF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15239">
        <property type="entry name" value="NUCLEAR EXPORT MEDIATOR FACTOR NEMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15239:SF6">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT NEMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05833">
        <property type="entry name" value="NFACT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NFACT RNA-binding" evidence="8">
        <location>
            <begin position="580"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="806"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="935"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="985"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1126"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="995"/>
            <end position="1006"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5486077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1204" mass="129822" checksum="218E4CC19E0A20F7" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HI33</accession>
    <name>A0A836HI33_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-tubulin N-acetyltransferase</fullName>
            <shortName evidence="3">Alpha-TAT</shortName>
            <shortName evidence="3">TAT</shortName>
            <ecNumber evidence="3">2.3.1.108</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Acetyltransferase mec-17 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_04468</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">LSCM4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-lysyl-[alpha-tubulin] + acetyl-CoA = N(6)-acetyl-L-lysyl-[alpha-tubulin] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15277"/>
            <dbReference type="Rhea" id="RHEA-COMP:11278"/>
            <dbReference type="Rhea" id="RHEA-COMP:11279"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.108"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase ATAT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.108" evidence="3"/>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062661.1">
        <property type="nucleotide sequence ID" value="XM_067206452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HI33"/>
    <dbReference type="SMR" id="A0A836HI33"/>
    <dbReference type="GeneID" id="92360386"/>
    <dbReference type="KEGG" id="loi:92360386"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019799">
        <property type="term" value="F:tubulin N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070507">
        <property type="term" value="P:regulation of microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000166">
        <property type="entry name" value="Alpha-tubulin N-acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03130">
        <property type="entry name" value="mec17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038746">
        <property type="entry name" value="Atat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007965">
        <property type="entry name" value="GNAT_ATAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12327">
        <property type="entry name" value="ALPHA-TUBULIN N-ACETYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12327:SF0">
        <property type="entry name" value="ALPHA-TUBULIN N-ACETYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05301">
        <property type="entry name" value="Acetyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51730">
        <property type="entry name" value="GNAT_ATAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="21"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="134"/>
            <end position="147"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="site" description="Crucial for catalytic activity" evidence="3">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5477250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="245" mass="27173" checksum="B8B236B9193736B5" modified="2021-09-29" version="1">MRRPAQLGRERLADEEVPELSSVPDGVSRWTGADLDSLHRATLRGGADATLQDLRQKLCRTIDILGARSQEAQQINAVLTSVARLRESNTFRLYLLTQSHRGVGILKMGVKKLFVTHPVTRGLVEVDPLCVLDFYVDESCQRQGYGKRLFMHMLEAEHVSRPAVLAIDRPSDKLLGFLKKHYGLRTCMPQANNFVVFDEFFDHTTVSERGRLLRAPSPVRALPSPFPTGASSAVGAIETKNIGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HII5</accession>
    <name>A0A836HII5_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_04562</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062754.1">
        <property type="nucleotide sequence ID" value="XM_067206545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HII5"/>
    <dbReference type="GeneID" id="92360479"/>
    <dbReference type="KEGG" id="loi:92360479"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5477343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="384" mass="43153" checksum="A892F7E656877C1E" modified="2021-09-29" version="1">MQSIIANFLSDIFIAEHETLLGRLMPWLAGGIVAFVAFPWVMMILYGLYFGVFLRPKEQAAMALSPLLTFLYFLTDEATPGFDQRLMRLFHPSLLEEEKDGGSVQRGLIRAMSRCLIDKFGKVTNIPRDTAVLKREGNNVNCMALVDFEKVKQVRCQLSWTRRPGVVKRYRQEGGRYPTRSAKESFVLNGIGIALPYTFQVTSFHIDPKKGEEFNILQYVRLVDFDDFGELFVRRLFEKPPRAAVSMMVQPLKEKYSSEESLATLQKCVQKVVDACGGLASSLDTVDVDQTSYKAIYAPQPEAASPPPGEPPIAKGEEDQKAPAIDGVDMVYHVKGVTRNVELYLRLTFSGLRALVTRYELRLLSDERPQVLVDHDTGETVVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HKP8</accession>
    <name>A0A836HKP8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CHAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_05748</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063452.1">
        <property type="nucleotide sequence ID" value="XM_067207679.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92361613"/>
    <dbReference type="KEGG" id="loi:92361613"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052410">
        <property type="entry name" value="DRC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24107:SF20">
        <property type="entry name" value="DYNEIN REGULATORY COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1049"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="254"/>
            <end position="294"/>
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    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1359"/>
            <end position="1390"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1359"/>
            <end position="1378"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1380"/>
            <end position="1390"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5479741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
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    </evidence>
    <sequence length="1431" mass="154819" checksum="889A53D3A6CB956D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HKQ1</accession>
    <name>A0A836HKQ1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GPR1/FUN34/yaaH family</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_08236</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000003">
        <property type="protein sequence ID" value="KAG5488012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_067210106.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="loi:92364040"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015360">
        <property type="term" value="F:acetate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:succinate transmembrane transport"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="SUCCINATE-ACETATE_PROTON SYMPORTER SATP"/>
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    </dbReference>
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        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
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            <end position="253"/>
        </location>
    </feature>
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        <location>
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    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5488012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="33055" checksum="21826A0887DFBDEA" modified="2021-09-29" version="1">MSTANSFKGDTTHEPIRAPSNADLRQFHEKYSGLNTQAPPVGQQEISYSQKQASVSRVRALKAKRQRLRELQEWEYQQATAPRRCANPGPLGLLGFGLSTILLNLHNTGSFPLSTVIVAMGICLGGGAQFIAGLLEWVRGNTFAYVAFTAYGAFWLSLVCVWLLPNTAAGTSTIVMPASEYFVGAYLFLWGVFSLFMFLCTIRMNVAIFLVFLTVTLLFMMLGGANMANNTTALHAAGYEGIICGSLALYLAFAEILSEVWDRTILPVIPMTQVLGWLGASEKPAEAVELKNSEHLPKDDGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HNX1</accession>
    <name>A0A836HNX1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_07620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000012">
        <property type="protein sequence ID" value="KAG5484848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064960.1">
        <property type="nucleotide sequence ID" value="XM_067209500.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92363434"/>
    <dbReference type="KEGG" id="loi:92363434"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF85">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="2278"/>
            <end position="2300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1723"/>
            <end position="1744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1817"/>
            <end position="1836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1920"/>
            <end position="1993"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2328"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2404"/>
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        </location>
    </feature>
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        <location>
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    </feature>
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        <location>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1819"/>
            <end position="1832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1973"/>
            <end position="1987"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2198"/>
            <end position="2217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2594"/>
            <end position="2608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5484848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="2905" mass="306271" checksum="0F8519A9628F9ACC" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HPN8</accession>
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            <fullName evidence="3">Glycosyltransferase (GlcNAc)</fullName>
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        <name evidence="1" type="ORF">LSCM4_06948</name>
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    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Leishmania</taxon>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG5481871.1"/>
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    </dbReference>
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    <dbReference type="KEGG" id="loi:92362791"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021067">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR34496">
        <property type="entry name" value="GLCNAC TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34496:SF11">
        <property type="entry name" value="GLYCOSYLTRANSFERASE (GLCNAC)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11397">
        <property type="entry name" value="GlcNAc"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5481871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="634" mass="70463" checksum="1B8C6DF41308BA63" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HT18</accession>
    <name>A0A836HT18_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">LSCM4_04853</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000014">
        <property type="protein sequence ID" value="KAG5483701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064640.1">
        <property type="nucleotide sequence ID" value="XM_067206831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HT18"/>
    <dbReference type="GeneID" id="92360765"/>
    <dbReference type="KEGG" id="loi:92360765"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5483701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="69" mass="7059" checksum="D79BA2D3F0A6B78D" modified="2021-09-29" version="1">MLATLCWVLVAALPAAKITTFIPLSVTMVFFLPCVFEAGGAAASVLLSQAGRCGIAAGIDFTSIAHLYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HWR5</accession>
    <name>A0A836HWR5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SURF1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_07851</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">LSCM4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Probably involved in the biogenesis of the COX complex.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SURF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000013">
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        <property type="entry name" value="SURFEIT LOCUS PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="SURFEIT LOCUS PROTEIN 1"/>
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        <property type="entry name" value="SURF1"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="26"/>
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    </feature>
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            <end position="353"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU363076"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5484285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="353" mass="40239" checksum="150D0CF7EC3FE125" modified="2021-09-29" version="1">MRPDYMGVMFLCTSVMSFNAGIWQIFRRSQKKQLMENHKNLEKSPLTDLPPENATVNECEFRRVRLDGSFDNEGSCLVGPRSIPSYKGAANEDESRGGFLVMTPFEIANTGAFVMVNRGWVPIDAGKHRTILKQYIGEGFAPGQVRGILRKEEFIGGSFFRGSSPDNEGPVAADLSWLAMRPWNMAMAYYRRRWGADHLKESAEKHGAHHYYVEMLEDFSGDDQRMVRGRAWPRRREVDEATYVHLTPVVHTMYIIFWFSVTAGSLYGMLRCWRRQQDIFALRKLANKQSMQLETRRQEEAQAYMKAVEEVERLKRISAAAAAAAQIDVDKSPAPAHTERAVSEGRGDSQSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HXD0</accession>
    <name>A0A836HXD0_9TRYP</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">LSCM4_06763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000009">
        <property type="protein sequence ID" value="KAG5486056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065387.1">
        <property type="nucleotide sequence ID" value="XM_067208676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HXD0"/>
    <dbReference type="GeneID" id="92362610"/>
    <dbReference type="KEGG" id="loi:92362610"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5486056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="528" mass="57212" checksum="72AE5BA78383E0C0" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HZM3</accession>
    <name>A0A836HZM3_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_06035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Gatherer D."/>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </evidence>
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        <source>
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    <sequence length="326" mass="36139" checksum="D1FAD8E0BB0CBA77" modified="2021-09-29" version="1">MFKGLLNPAVESRAARRLATVANSARRGDLKQSHETVRQSTRLLEKLQRHQGRGRTRTAHQRARFNSPTDSLISTESWAAAQAEALAQEEANWRAADPMRKWKDEAEERGRQHGAEDGAYSGPGPARPAPLPHYDTVNADTGNSAVQERFDALVHRALLRYGPPLPVEVAMGINVVSAAAFASGAHLHAYRSYPAANVNADKGADDSSAAYYDEVALKVHELMTILRKEKPHFSVRSDCDGVPLSLMVKNCCYLRAFGGKVNYMRFVRRLRTDELQSCGNSRGGAQDAHEANVAVLSIGKYKMRELPSQDGIRQGPQPWRYSYRMV</sequence>
</entry>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="1 4">Belongs to the EF-1-beta/EF-1-delta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG5464704.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
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    <sequence length="208" mass="22774" checksum="138EA499474EFE1D" modified="2021-09-29" version="1">MSSLKEVNGRLSTQPFVSGFSPSSEDARIFGEMFGSNLNVVQWVARMASYYQAERDAILNSGSEKAAEPAKKTPAPAPAAAAADDDDIDLFGDATEEEQAALEAKKAKDAEKKKAKKDVIAKSSILFDIKAWDDTVDLKALAQKLHAIQRDGLIWGDHKLVPVAYGVKKLQQLIVIEDDKVSGDDLEEMIMGFEDEVQSMDIVAWNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836K6K1_9TRYP</name>
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    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
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                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067202519.1"/>
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    <dbReference type="SMR" id="A0A836K6K1"/>
    <dbReference type="GeneID" id="92356453"/>
    <dbReference type="KEGG" id="loi:92356453"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:002206">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051730">
        <property type="entry name" value="NASP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15081:SF1">
        <property type="entry name" value="NUCLEAR AUTOANTIGENIC SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15081">
        <property type="entry name" value="NUCLEAR AUTOANTIGENIC SPERM PROTEIN NASP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="349"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="349"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="401"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5464989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="412" mass="45451" checksum="37AB8ECC75BB5F56" modified="2021-09-29" version="1">MSEEAQHHMQEDEDHLPKAEKGASERDRQEEEASSTSSDEHEEAEEAEEEEDDEDANFQFATDEEAEAQRQVGVAAYNEGRYEDALDVQYCVVRHFSNKYGSTSPKCGKYFLDYGLSQLRLLQGQTTVDDVLQPRDEDALMSCYVNLEVARVCFQKLEAEAGDEDVEVELALAEVHNALAQLSVEKEDYDAALREYEAELLQYRCLQDAAPEEEKLTIVPAGRVIGVLYGIADCFMKEGDFEGAEERLRATLDEIKLYPTGTIAASLIAELEDLLADAAEMKNGKFQEIQDAIKQQFAAEAEQIPTPQEFFSLDKDGKHPFLSAVPGGTGDEVAETSYLSMPMSASGQALATNEHSNSLSVSLFPPQGSRSGTPSGPMQHATVKKKQKRIGDDSLSNAQPENKRPRAESASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KAA4</accession>
    <name>A0A836KAA4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_00223</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058413.1">
        <property type="nucleotide sequence ID" value="XM_067202312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KAA4"/>
    <dbReference type="SMR" id="A0A836KAA4"/>
    <dbReference type="GeneID" id="92356246"/>
    <dbReference type="KEGG" id="loi:92356246"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="134"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="320"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="504"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="538"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5464782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="570" mass="62784" checksum="47A5E5EC009BE3EA" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KAG7</accession>
    <name>A0A836KAG7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">riboflavin kinase</fullName>
            <ecNumber evidence="2">2.7.1.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_01506</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.26" evidence="2"/>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059246.1">
        <property type="nucleotide sequence ID" value="XM_067203555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KAG7"/>
    <dbReference type="SMR" id="A0A836KAG7"/>
    <dbReference type="GeneID" id="92357489"/>
    <dbReference type="KEGG" id="loi:92357489"/>
    <dbReference type="UniPathway" id="UPA00276">
        <property type="reaction ID" value="UER00406"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="entry name" value="Riboflavin kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023468">
        <property type="entry name" value="Riboflavin_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015865">
        <property type="entry name" value="Riboflavin_kinase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749:SF6">
        <property type="entry name" value="RIBOFLAVIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749">
        <property type="entry name" value="RIBOFLAVIN KINASE/FMN ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01687">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00904">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="Riboflavin kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Riboflavin kinase" evidence="8">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5466356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="183" mass="20411" checksum="80D67181E69680B5" modified="2021-09-29" version="1">MKPWFLRGKVIHGYGRGGTQLGYPTANLELSEAAIEFLRPHNNLVLWGWGCVEAAESKTGKACAEDASPEPLGPFPFVMSIGNNPHFKNADVSAEVHFLHKFEGDFYDRVVRIVTLESIRSQSVFTTLEDLIKTIDGDVVFAKERLRLPQWASYAQHNMANPACVPAQLNDTVQLPYFGFLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KAN1</accession>
    <name>A0A836KAN1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zeta toxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_01718</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059456.1">
        <property type="nucleotide sequence ID" value="XM_067203765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KAN1"/>
    <dbReference type="GeneID" id="92357699"/>
    <dbReference type="KEGG" id="loi:92357699"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33477:SF2">
        <property type="entry name" value="2-PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33477">
        <property type="entry name" value="P-LOOP NTPASE DOMAIN-CONTAINING PROTEIN LPA1 HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5466566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="33604" checksum="0FD4814635B25509" modified="2021-09-29" version="1">MSSKYDVIKVKVHLTDAHYYVLSRYFLSKMLMFCRVPEDTAVRISLDVKKHFVNSERTTITQAELEDHIRCSMVAAGFAREHAQLFSVVTKFHAERIPLILFIAGPRQCGKTTLAHLLATRLNCSTVINAEIMRDISASVDDSLPSFALSDATSPYSASATLRGVEVAAAVSAEVDKTVQEGRSIIIEGENLSFAGFHRFLEPSFQLSTGSVVLGLVMETSRHEAEPDVSHAYVKSLSNLQLIFSTARVSLYAADVGNLAGGVSGIPTVFVARCTTVAANLCLSLFLHDIVVKRIVAELERRERRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KBW0</accession>
    <name>A0A836KBW0_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_01063</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059778.1">
        <property type="nucleotide sequence ID" value="XM_067203128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KBW0"/>
    <dbReference type="SMR" id="A0A836KBW0"/>
    <dbReference type="GeneID" id="92357062"/>
    <dbReference type="KEGG" id="loi:92357062"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051500">
        <property type="term" value="F:D-tyrosyl-tRNA(Tyr) deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.80.10:FF:000008">
        <property type="entry name" value="Putative D-tyrosyl-tRNA(Tyr) deacylase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.80.10">
        <property type="entry name" value="D-tyrosyl-tRNA(Tyr) deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003732">
        <property type="entry name" value="Daa-tRNA_deacyls_DTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023509">
        <property type="entry name" value="DTD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472:SF1">
        <property type="entry name" value="D-AMINOACYL-TRNA DEACYLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472">
        <property type="entry name" value="D-TYROSYL-TRNA TYR DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02580">
        <property type="entry name" value="Tyr_Deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69500">
        <property type="entry name" value="DTD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5467976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="201" mass="22426" checksum="94C3ED77829D64D9" modified="2021-09-29" version="1">MYLIQYKKCVCVRHIMTIRVVLQAMDQAQLLVDNIEKYVRAGRGAIVYIAFLADGDGTEITDEAVRHSVDILLQTKIFTHFSPEKMITRPQSLEECPEMDILIVPQASLGGKLKGRSVQFHQLVDKAVGAALYGRFCHFVRVARGVDETRVDANGAPLNQEDAPNAGGWIKYNSRVISGTFGNRQGLRFESEGPFTHAFDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KCU0</accession>
    <name>A0A836KCU0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">fumarate reductase (NADH)</fullName>
            <ecNumber evidence="6">1.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">NADH-dependent fumarate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_01257</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>succinate + NAD(+) = fumarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18281"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.3.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.6" evidence="6"/>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059005.1">
        <property type="nucleotide sequence ID" value="XM_067203314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KCU0"/>
    <dbReference type="SMR" id="A0A836KCU0"/>
    <dbReference type="GeneID" id="92357248"/>
    <dbReference type="KEGG" id="loi:92357248"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016156">
        <property type="term" value="F:fumarate reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000021">
        <property type="entry name" value="Cytochrome b5 reductase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000007">
        <property type="entry name" value="NADH-dependent fumarate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.520.10">
        <property type="entry name" value="ApbE-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024932">
        <property type="entry name" value="ApbE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003374">
        <property type="entry name" value="ApbE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050315">
        <property type="entry name" value="FAD-oxidoreductase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010960">
        <property type="entry name" value="Flavocytochrome_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01813">
        <property type="entry name" value="flavo_cyto_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400:SF7">
        <property type="entry name" value="FAD-DEPENDENT OXIDOREDUCTASE 2 FAD BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02424">
        <property type="entry name" value="ApbE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143631">
        <property type="entry name" value="ApbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="8">
        <location>
            <begin position="989"/>
            <end position="1097"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00050832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00077246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5466115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1244" mass="135137" checksum="608EB74CC4A19460" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KCX0</accession>
    <name>A0A836KCX0_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_00851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059569.1">
        <property type="nucleotide sequence ID" value="XM_067202919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KCX0"/>
    <dbReference type="GeneID" id="92356853"/>
    <dbReference type="KEGG" id="loi:92356853"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19851">
        <property type="entry name" value="OS02G0203500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19851:SF12">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5467767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="557" mass="59700" checksum="8496F3A65CBCE869" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KF01</accession>
    <name>A0A836KF01_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ERF1 methyltransferase catalytic subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_02891</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic/archaeal PrmC-related family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060463.1">
        <property type="nucleotide sequence ID" value="XM_067204911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KF01"/>
    <dbReference type="GeneID" id="92358845"/>
    <dbReference type="KEGG" id="loi:92358845"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035657">
        <property type="term" value="C:eRF1 methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052190">
        <property type="entry name" value="Euk-Arch_PrmC-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875:SF1">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5470197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="337" mass="36772" checksum="AC99B6589DECC89A" modified="2021-09-29" version="1">MGSITVPAYSSPEYMHCISDSRFRQNVYEPEADTFLFLEALDKDAELLRSLQPERCVEVGCGSGTVITHLRCLLMPPVVAAGTEAVSSVKPEPRCRTSGTRGAVGGPVFCAVDVNPLALEATAITWTETLLKYFRASVLTNFYERMFQRPVPASLAAPVVSSAEGSVSPSPLVHADDTTGSALSASTFCLHRFHGDLFSALCQAGPGSAPFDVVLFNPPYVPTSLEELQDAVTQKDVITTAWCGGPRGRIVLDRFLTQLPSMLSRRGVCYVVLIRENDMADVVAFAQAVFREHLRGSEMEAVRDEDGVLEAAEVAARYTGEHLSVYRLRYLPQFLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KF28</accession>
    <name>A0A836KF28_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060738.1">
        <property type="nucleotide sequence ID" value="XM_067205186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KF28"/>
    <dbReference type="GeneID" id="92359120"/>
    <dbReference type="KEGG" id="loi:92359120"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5471621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="129" mass="14064" checksum="A39574272ACE9808" modified="2021-09-29" version="1">MSYPPPPLGGPPLEYNPYPPSVVQYPNPQYGPPPPGLYGAPPPPPQPYEMPPQPYGTPNLYGAPYGPPPPPTQPQVILVQQPAPPPPPPQTIVVHSNGGGCGDYYCRRCRRYHRSRHDCPYNRFGCGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KFQ1</accession>
    <name>A0A836KFQ1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TOG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_02481</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates M.D."/>
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                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Bates M.D."/>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
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        <property type="entry name" value="Smp-1-like_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR10183:SF423">
        <property type="entry name" value="LEUCINE-RICH REPEAT PROTEIN (LRRP)"/>
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    </dbReference>
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            <end position="592"/>
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        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
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            <end position="76"/>
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    <feature type="active site" evidence="1">
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            <position position="507"/>
        </location>
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    <feature type="active site" evidence="1">
        <location>
            <position position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5471578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="784" mass="89393" checksum="944F5EBA733CA08D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
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            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000020">
        <property type="protein sequence ID" value="KAG5480366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063697.1">
        <property type="nucleotide sequence ID" value="XM_067208057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KN00"/>
    <dbReference type="SMR" id="A0A836KN00"/>
    <dbReference type="GeneID" id="92361991"/>
    <dbReference type="KEGG" id="loi:92361991"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 20"/>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5480366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="144" mass="16759" checksum="58416FE38B7A24A6" modified="2021-09-29" version="1">MGYTRERTNRHFFVSRANAFFSRLPIARIQRALAMESIKKGHMKPWKHTKEQIIGSPITCNFEYNPRPVRLIGTVMDAHTEETSIKGGLKVYARNEEANMMLWIPAGNPKLKYEVTSAKGSFEHYLDERSKWDEAWLTGRARMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KN07</accession>
    <name>A0A836KN07_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_07141</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000018">
        <property type="protein sequence ID" value="KAG5481429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064108.1">
        <property type="nucleotide sequence ID" value="XM_067209045.1"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A836KN07"/>
    <dbReference type="GeneID" id="92362979"/>
    <dbReference type="KEGG" id="loi:92362979"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052812">
        <property type="entry name" value="Plant_DnaJ_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44272">
        <property type="entry name" value="DNAJ DOMAIN (PROKARYOTIC HEAT SHOCK PROTEIN)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44272:SF3">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="5"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="574"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="886"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1034"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="574"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="896"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="912"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1034"/>
            <end position="1049"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5481429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1115" mass="120945" checksum="BC38674EB05B55C6" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KN34</accession>
    <name>A0A836KN34_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000020">
        <property type="protein sequence ID" value="KAG5480471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067208162.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="92362096"/>
    <dbReference type="KEGG" id="loi:92362096"/>
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        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="891"/>
            <end position="926"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5480471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="975" mass="104252" checksum="879F883EBEC53C57" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KNS0</accession>
    <name>A0A836KNS0_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_04523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062716.1">
        <property type="nucleotide sequence ID" value="XM_067206507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KNS0"/>
    <dbReference type="GeneID" id="92360441"/>
    <dbReference type="KEGG" id="loi:92360441"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="640"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="941"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="960"/>
            <end position="972"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5477305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="972" mass="105385" checksum="CFE8461523CED3CA" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KP11</accession>
    <name>A0A836KP11_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000016">
        <property type="protein sequence ID" value="KAG5482404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064410.1">
        <property type="nucleotide sequence ID" value="XM_067207596.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836KP11"/>
    <dbReference type="GeneID" id="92361530"/>
    <dbReference type="KEGG" id="loi:92361530"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1331"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1689"/>
            <end position="1826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1331"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1703"/>
            <end position="1712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1713"/>
            <end position="1724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1751"/>
            <end position="1771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1781"/>
            <end position="1790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5482404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1826" mass="201555" checksum="2A1D39F21CCBCDB9" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KPX6</accession>
    <name>A0A836KPX6_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_04693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000023">
        <property type="protein sequence ID" value="KAG5478460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063121.1">
        <property type="nucleotide sequence ID" value="XM_067206674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KPX6"/>
    <dbReference type="GeneID" id="92360608"/>
    <dbReference type="KEGG" id="loi:92360608"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="768"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5478460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="850" mass="86459" checksum="A00E5C2A2A5B24C2" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KQ12</accession>
    <name>A0A836KQ12_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_04798</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ANT/ATPSC lysine N-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000023">
        <property type="protein sequence ID" value="KAG5478565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063226.1">
        <property type="nucleotide sequence ID" value="XM_067206779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KQ12"/>
    <dbReference type="SMR" id="A0A836KQ12"/>
    <dbReference type="GeneID" id="92360713"/>
    <dbReference type="KEGG" id="loi:92360713"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905706">
        <property type="term" value="P:regulation of mitochondrial ATP synthesis coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026170">
        <property type="entry name" value="FAM173A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13610">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13610:SF11">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5478565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="241" mass="26028" checksum="CE8E62283A76AF6A" modified="2021-09-29" version="1">MFDLPFQWDDGHCVSPFVAASEADMKAFAGWLTARYLSPIVQHSTVSSRCRADQLCAVSQQHEMLLTDLGCGDATAALSLAKHLRRGWCDLRSNTDDASSTDGATSLHIIVTGIDLDDALLVTAAANASAFAIAVASPSSSPVSVETHLLSEDLRTVDLDVHFPRCAQRGAAPLLAPTQPPYVLYMYLLPDALALLRGKLLDIMERGWLVASNRWPVPGLEAFLRDRAGNVHIYAYAAPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KSW5</accession>
    <name>A0A836KSW5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">LSCM4_07999</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">LSCM4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000013">
        <property type="protein sequence ID" value="KAG5484432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064925.1">
        <property type="nucleotide sequence ID" value="XM_067209875.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836KSW5"/>
    <dbReference type="GeneID" id="92363809"/>
    <dbReference type="KEGG" id="loi:92363809"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036156">
        <property type="term" value="C:inner dynein arm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060294">
        <property type="term" value="P:cilium movement involved in cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036159">
        <property type="term" value="P:inner dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.30:FF:000003">
        <property type="entry name" value="Dynein axonemal heavy chain 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000219">
        <property type="entry name" value="Dynein axonemal heavy chain 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1220:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2620:FF:000002">
        <property type="entry name" value="Dynein heavy chain 2, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000001">
        <property type="entry name" value="dynein heavy chain 2, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.20:FF:000009">
        <property type="entry name" value="Dynein heavy chain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000002">
        <property type="entry name" value="Dynein heavy chain 9, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.130:FF:000020">
        <property type="entry name" value="Dynein heavy chain, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000017">
        <property type="entry name" value="Dynein heavy chain, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1120:FF:000015">
        <property type="entry name" value="Dynein heavy chain, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002034">
        <property type="entry name" value="Dynein heavy chain, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000049">
        <property type="entry name" value="Dynein, axonemal, heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000007">
        <property type="entry name" value="Putative dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041589">
        <property type="entry name" value="DNAH3_AAA_lid_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013594">
        <property type="entry name" value="Dynein_heavy_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703">
        <property type="entry name" value="DYNEIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703:SF8">
        <property type="entry name" value="DYNEINS HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17857">
        <property type="entry name" value="AAA_lid_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08385">
        <property type="entry name" value="DHC_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="9 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="1915"/>
            <end position="2014"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="2542"/>
            <end position="2695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="4083"/>
            <end position="4148"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="3157"/>
            <end position="3184"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="3365"/>
            <end position="3427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="4101"/>
            <end position="4110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="4122"/>
            <end position="4133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="4134"/>
            <end position="4147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG5484432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="4663" mass="528939" checksum="6ACA218D612F2018" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KUC4</accession>
    <name>A0A836KUC4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Oxidation resistance protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_07801</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OXR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000006">
        <property type="protein sequence ID" value="KAG5487311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065808.1">
        <property type="nucleotide sequence ID" value="XM_067209678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KUC4"/>
    <dbReference type="GeneID" id="92363612"/>
    <dbReference type="KEGG" id="loi:92363612"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354:SF62">
        <property type="entry name" value="MUSTARD, ISOFORM V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354">
        <property type="entry name" value="NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="6">
        <location>
            <begin position="137"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="314"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="533"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="533"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5487311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="663" mass="70505" checksum="3C0EC81D6C56A6BF" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KUS1</accession>
    <name>A0A836KUS1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SPX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_07388</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">LSCM4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000008">
        <property type="protein sequence ID" value="KAG5486457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065523.1">
        <property type="nucleotide sequence ID" value="XM_067209280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KUS1"/>
    <dbReference type="SMR" id="A0A836KUS1"/>
    <dbReference type="GeneID" id="92363214"/>
    <dbReference type="KEGG" id="loi:92363214"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000087">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000101">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF111">
        <property type="entry name" value="PYROPHOSPHOKINASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPX" evidence="3">
        <location>
            <begin position="12"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5486457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="826" mass="91059" checksum="1988351626D5E7EA" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KV57</accession>
    <name>A0A836KV57_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_08191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000002">
        <property type="protein sequence ID" value="KAG5488211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066259.1">
        <property type="nucleotide sequence ID" value="XM_067210061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KV57"/>
    <dbReference type="GeneID" id="92363995"/>
    <dbReference type="KEGG" id="loi:92363995"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5488211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="315" mass="34321" checksum="CBCF9843E15CB7CE" modified="2021-09-29" version="1">MASTDAESPPVETPPFPRSESHRNPSDTATGGALPPASTAASSEEMKRLTTLGTLLVNMGAASEEKVFGMKDSAPMLAYRDHRMHDLLIINRPQDDAAAHPFIWYRPWTWWSSGARVSPLVVWRKPAPEERAREPVMAAPPVIAASTQTERDRASPPSSDLGEPKAAPPPKRKKGLPVVDMRALTDEEVDALTPSVRDERAKLLRSEKHIHETLQGMEDTRYRYLVPSRDLKCEAEVLDVVRCYAERNQATAASLAAEGGDAPPGATAALHNEASDVGEKTVVRADLLACGPQVQRLRVCAESMVMKYSLEGDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KVT4</accession>
    <name>A0A836KVT4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Iron hydrogenase large subunit C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_08027</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">LSCM4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NARF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000005">
        <property type="protein sequence ID" value="KAG5487582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065870.1">
        <property type="nucleotide sequence ID" value="XM_067209903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KVT4"/>
    <dbReference type="GeneID" id="92363837"/>
    <dbReference type="KEGG" id="loi:92363837"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000042">
        <property type="entry name" value="Cytosolic Fe-S cluster assembly factor NAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.950.10">
        <property type="entry name" value="Fe-only Hydrogenase (Larger Subunit), Chain L, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050340">
        <property type="entry name" value="Cytosolic_Fe-S_CAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009016">
        <property type="entry name" value="Fe_hydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004108">
        <property type="entry name" value="Fe_hydrogenase_lsu_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11615">
        <property type="entry name" value="NITRATE, FORMATE, IRON DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02906">
        <property type="entry name" value="Fe_hyd_lg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53920">
        <property type="entry name" value="Fe-only hydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iron hydrogenase large subunit C-terminal" evidence="7">
        <location>
            <begin position="202"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5487582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="653" mass="68457" checksum="51B5A448989DADC6" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836L452</accession>
    <name>A0A836L452_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA nucleotidyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_07579</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000004">
        <property type="protein sequence ID" value="KAG5487898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066095.1">
        <property type="nucleotide sequence ID" value="XM_067209463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836L452"/>
    <dbReference type="GeneID" id="92363397"/>
    <dbReference type="KEGG" id="loi:92363397"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052929">
        <property type="term" value="F:ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052927">
        <property type="term" value="F:CC tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001680">
        <property type="term" value="P:tRNA 3'-terminal CCA addition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3090.10">
        <property type="entry name" value="cca-adding enzyme, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13734:SF5">
        <property type="entry name" value="CCA TRNA NUCLEOTIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13734">
        <property type="entry name" value="TRNA-NUCLEOTIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81891">
        <property type="entry name" value="Poly A polymerase C-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly A polymerase head" evidence="6">
        <location>
            <begin position="36"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding" evidence="7">
        <location>
            <begin position="230"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5487898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="523" mass="58891" checksum="1F0237B25A6EB726" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836L4G9</accession>
    <name>A0A836L4G9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.205</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">2'-O-ribose RNA methyltransferase TRM7 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_08162</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>cytidine(32)/guanosine(34) in tRNA + 2 S-adenosyl-L-methionine = 2'-O-methylcytidine(32)/2'-O-methylguanosine(34) in tRNA + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42396"/>
            <dbReference type="Rhea" id="RHEA-COMP:10246"/>
            <dbReference type="Rhea" id="RHEA-COMP:10247"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74445"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.205"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.205" evidence="7"/>
    <dbReference type="EMBL" id="JAFHLR010000002">
        <property type="protein sequence ID" value="KAG5488183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066231.1">
        <property type="nucleotide sequence ID" value="XM_067210033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836L4G9"/>
    <dbReference type="SMR" id="A0A836L4G9"/>
    <dbReference type="GeneID" id="92363967"/>
    <dbReference type="KEGG" id="loi:92363967"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106340">
        <property type="term" value="F:tRNA (guanosine(34)-2'-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002128">
        <property type="term" value="P:tRNA nucleoside ribose methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03162">
        <property type="entry name" value="RNA_methyltr_E_TRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028590">
        <property type="entry name" value="RNA_methyltr_E_TRM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF12">
        <property type="entry name" value="TRNA (CYTIDINE(32)_GUANOSINE(34)-2'-O)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="9">
        <location>
            <begin position="21"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="127"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="383"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="386"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="424"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5488183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="434" mass="46014" checksum="A0FCB55A3FF55348" modified="2021-09-29" version="1">MGRASKDKRDIYYRKAKEEGYRARSAYKLLQIHEEFNILDPAKIRTGAVDLCAAPGSWSQVLAQHFKMIGAHATAAGAAPSPPTPRVVAVDLQEMAPIDGVAILQGDITSEETAYEIIRILNAPKSTGVMSTDDEQQQPVGSPSSSPPPTLPTASPRKADIVICDGAPDVTGMHELDEYLQHHLLLAALHITTFVLRAGGCFLTKMFRGPNTAFLVAKSEVFFEQVRVVKPKSSRNASMESFLLCQGFRLPPGYVPRFTNAAAAVADFAGHPSAGHASSETGELSEEAILRGGPLRASGFTPEAPSYCYDTTASSSRASAAGATVAQDITRGGERMSCALADRVLAPFLSCGDLSGFDADMCYDRDEEADVLQPVQPPLQAPYLTAAAVSSPPSAKSTGGRDTQAEASEKKKVRVEAPTGAANCGNNTSGEVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FP67</accession>
    <name>A0A836FP67_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DM10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_01588</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059327.1">
        <property type="nucleotide sequence ID" value="XM_067203636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836FP67"/>
    <dbReference type="SMR" id="A0A836FP67"/>
    <dbReference type="GeneID" id="92357570"/>
    <dbReference type="KEGG" id="loi:92357570"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005879">
        <property type="term" value="C:axonemal microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04412">
        <property type="entry name" value="NDPk7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.141:FF:000004">
        <property type="entry name" value="Nucleoside diphosphate kinase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006602">
        <property type="entry name" value="DM10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057579">
        <property type="entry name" value="DM10_NDK7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037993">
        <property type="entry name" value="NDPk7B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43109">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43109:SF1">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25364">
        <property type="entry name" value="PH_NDK7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00676">
        <property type="entry name" value="DM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51336">
        <property type="entry name" value="DM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DM10" evidence="7">
        <location>
            <begin position="3"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5466437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="337" mass="37014" checksum="0C3A49C63B91A67A" modified="2021-09-29" version="1">MVGEQRDTFVVEYFDPQAGLSRTYQFCYFTDDKTIEMYDLKTKRLFLKRCAYPSLSPNELYVGATINVFSRPLRIVGYGDDATRKRLTTDSCECMITVDMEHHSAVAGSVVEALTTQGLRITFIRLVELSQGLAARVASKAQRCLVLLVSGAGAREKVASVAASFSAAVSQISSDGAVQELREAVMGPGEPTAALKNCAVCVIKPHAITSGYHGPILHRLVQEGFYISAIGSYQLTVADAEDFLEVYNGVLPEYKKLVEQMSSGPCWAIEVCAENAVPALRAVCGPHDPEVCHALFPHSLRSKYGIDRIRNAVHCTDLEEDGPLESEFFFSLLQNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FVV8</accession>
    <name>A0A836FVV8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Protein N-terminal glutamine amidohydrolase</fullName>
            <ecNumber evidence="3 8">3.5.1.122</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 8">Protein NH2-terminal glutamine deamidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_02987</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>N-terminal L-glutaminyl-[protein] + H2O = N-terminal L-glutamyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:50680"/>
            <dbReference type="Rhea" id="RHEA-COMP:12668"/>
            <dbReference type="Rhea" id="RHEA-COMP:12777"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:64721"/>
            <dbReference type="ChEBI" id="CHEBI:64722"/>
            <dbReference type="EC" id="3.5.1.122"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2 8">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the NTAQ1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.122" evidence="3 8"/>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060558.1">
        <property type="nucleotide sequence ID" value="XM_067205006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836FVV8"/>
    <dbReference type="SMR" id="A0A836FVV8"/>
    <dbReference type="GeneID" id="92358940"/>
    <dbReference type="KEGG" id="loi:92358940"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008418">
        <property type="term" value="F:protein-N-terminal asparagine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070773">
        <property type="term" value="F:protein-N-terminal glutamine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.620.10">
        <property type="entry name" value="Protein N-terminal glutamine amidohydrolase, alpha beta roll"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037132">
        <property type="entry name" value="N_Gln_amidohydro_ab_roll_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039733">
        <property type="entry name" value="NTAQ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023128">
        <property type="entry name" value="Prot_N_Gln_amidohydro_ab_roll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13035">
        <property type="entry name" value="PROTEIN N-TERMINAL GLUTAMINE AMIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13035:SF0">
        <property type="entry name" value="PROTEIN N-TERMINAL GLUTAMINE AMIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09764">
        <property type="entry name" value="Nt_Gln_amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein N-terminal glutamine amidohydrolase alpha beta roll" evidence="9">
        <location>
            <begin position="7"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5470292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="241" mass="27439" checksum="ECC51308EBA9C832" modified="2021-09-29" version="1">MTRPLEYAFCYCEENVYKFLETISTMNDIFDRSCAVFMTSFCCRPCDEVLNEWTSVVPYRPYESSELEKDLIVWDYHVIALVRATHAGKWYVVDQDSKLPPTEDAELGSLAPHCIDLHTYVTQVLFLDTATSHSVCSELTELLNRVRYRVVEREDYLSFLRSDRSHMQKAPGVYRAKPPPWPSVSGSSASVGDEVKKRAEAVLSALPSNLRANNLVCFINAANTSIPGVVMDRHSFEDFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G6N8</accession>
    <name>A0A836G6N8_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062465.1">
        <property type="nucleotide sequence ID" value="XM_067207162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G6N8"/>
    <dbReference type="SMR" id="A0A836G6N8"/>
    <dbReference type="GeneID" id="92361096"/>
    <dbReference type="KEGG" id="loi:92361096"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="327"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5476232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="886" mass="93981" checksum="A561CB4EBA5DF55F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G7Q1</accession>
    <name>A0A836G7Q1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_01116</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5468029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059831.1">
        <property type="nucleotide sequence ID" value="XM_067203181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G7Q1"/>
    <dbReference type="GeneID" id="92357115"/>
    <dbReference type="KEGG" id="loi:92357115"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000190">
        <property type="entry name" value="DnaJ domain containing protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050817">
        <property type="entry name" value="DjlA_DnaK_co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24074">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DJLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="615"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="582"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5468029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="689" mass="75430" checksum="6AE5E506FFB5B768" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G8Y0</accession>
    <name>A0A836G8Y0_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03052</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060622.1">
        <property type="nucleotide sequence ID" value="XM_067205070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G8Y0"/>
    <dbReference type="SMR" id="A0A836G8Y0"/>
    <dbReference type="GeneID" id="92359004"/>
    <dbReference type="KEGG" id="loi:92359004"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="27"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5470356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="200" mass="22458" checksum="240A3E277CEC4441" modified="2021-09-29" version="1">MSKPSLCRSERSARSTQDRVHYVRAQRQHLVRETQMLRMALEELQEEAEQANGEEALARRAIDERHRELLRCLLHLSVAELDTTGSKAQAAGAQVQPEATSAIVCEVLRQYKAEQDTFTQEVNQHLEQLRKEAQQSCVSVGDTSVVHLPEQDHRSSVDSIAEEAELNSLRSELEALCEMKATVDEETEAAMLSVGRGLFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G9A3</accession>
    <name>A0A836G9A3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Archaic translocase of outer membrane 11 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5468959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059936.1">
        <property type="nucleotide sequence ID" value="XM_067204384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G9A3"/>
    <dbReference type="SMR" id="A0A836G9A3"/>
    <dbReference type="GeneID" id="92358318"/>
    <dbReference type="KEGG" id="loi:92358318"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5468959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="99" mass="10751" checksum="51BA55514C3777E1" modified="2021-09-29" version="1">MMFGRSHAPQKEWGSMYFYEKLHHLVDHTSNFVISKVDWWIPSVAVGIVLSLFILGGPEALPQAASIILPSATPAVTAPQFATPEGPQSGAAPEDDEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G9L8</accession>
    <name>A0A836G9L8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase</fullName>
            <ecNumber evidence="4">3.2.1.96</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_02552</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>an N(4)-(oligosaccharide-(1-&gt;3)-[oligosaccharide-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + H2O = an oligosaccharide-(1-&gt;3)-[oligosaccharide-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-D-GlcNAc + N(4)-(N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:73067"/>
            <dbReference type="Rhea" id="RHEA-COMP:12603"/>
            <dbReference type="Rhea" id="RHEA-COMP:18176"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:132248"/>
            <dbReference type="ChEBI" id="CHEBI:192714"/>
            <dbReference type="ChEBI" id="CHEBI:192715"/>
            <dbReference type="EC" id="3.2.1.96"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DeSI family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 85 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.96" evidence="4"/>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060131.1">
        <property type="nucleotide sequence ID" value="XM_067204579.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836G9L8"/>
    <dbReference type="GeneID" id="92358513"/>
    <dbReference type="KEGG" id="loi:92358513"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033925">
        <property type="term" value="F:mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06547">
        <property type="entry name" value="GH85_ENGase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09212">
        <property type="entry name" value="PUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000043">
        <property type="entry name" value="cytosolic endo-beta-N-acetylglucosaminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.2190:FF:000010">
        <property type="entry name" value="Glycosyl hydrolase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1720.30:FF:000006">
        <property type="entry name" value="Glycosyl hydrolase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032979">
        <property type="entry name" value="ENGase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036339">
        <property type="entry name" value="PUB-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018997">
        <property type="entry name" value="PUB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005201">
        <property type="entry name" value="TIM_ENGase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13246:SF1">
        <property type="entry name" value="CYTOSOLIC ENDO-BETA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13246">
        <property type="entry name" value="ENDO BETA N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03644">
        <property type="entry name" value="Glyco_hydro_85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09409">
        <property type="entry name" value="PUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01179">
        <property type="entry name" value="DUF862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143503">
        <property type="entry name" value="PUG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPPDE" evidence="10">
        <location>
            <begin position="7"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5469154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1405" mass="152243" checksum="C75174B2FEB03AC7" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G9M6</accession>
    <name>A0A836G9M6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CP-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_02567</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060146.1">
        <property type="nucleotide sequence ID" value="XM_067204594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G9M6"/>
    <dbReference type="SMR" id="A0A836G9M6"/>
    <dbReference type="GeneID" id="92358528"/>
    <dbReference type="KEGG" id="loi:92358528"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1580.10:FF:000015">
        <property type="entry name" value="Ras-like small GTPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050755">
        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF30">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN-LIKE 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="4">
        <location>
            <begin position="189"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="543"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="552"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5469169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="565" mass="62615" checksum="919D329E71281486" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GBH0</accession>
    <name>A0A836GBH0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LSCM4_03399</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">LSCM4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060958.1">
        <property type="nucleotide sequence ID" value="XM_067205406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GBH0"/>
    <dbReference type="GeneID" id="92359340"/>
    <dbReference type="KEGG" id="loi:92359340"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048284">
        <property type="term" value="P:organelle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057308">
        <property type="entry name" value="CHCR_PEP5_VPS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057307">
        <property type="entry name" value="PEP5_VPS11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF24">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23341">
        <property type="entry name" value="PEP5_VPS11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23356">
        <property type="entry name" value="TPR_PEP5_VPS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="CHCR" evidence="10">
        <location>
            <begin position="566"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="1075"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="800"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1205"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="1205"/>
            <end position="1214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG5471841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1224" mass="132858" checksum="5910686987BD08F0" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GD50</accession>
    <name>A0A836GD50_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_00484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CFAP298 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PROTEIN C21ORF59"/>
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    </dbReference>
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        <property type="entry name" value="CFAP298"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5465032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="267" mass="29644" checksum="B24577DE0F205201" modified="2021-09-29" version="1">MVLLECKRLPKEEYSKDYDAFIASMPVTTNIGEATDAIQKMQNTRVRLTWMMAAAKQMVKDGMVDAAQQHYLTGPIGDTERYLSIERTERRQLCVQNELDALVEAFKGGVMILFPAECSGSDACQRLAAVLDSDTASDIEKSKAHRILSIIDDGATNENILVGRAVMWWSAKPLARDADFAKYIGKNDKSKMTVKLVAEGGAAPPREPAVDAKAQAELIQHFYRKQEEMKKLVEDEDISFGSSAWANPHGLKNQLQGLDSIHYKGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836GD79_9TRYP</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="3" type="ORF">LSCM4_02677</name>
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    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
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            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5469989.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5469989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="125" mass="13939" checksum="5A212482F80DCC61" modified="2021-09-29" version="1">MPISEDAASTPPPKPRRSVANYTEPPPKNPYLVKLSRFYSTKIPMGVREFVFTGPLLLLTFGVAYFIPSLVPVEQFTQGLTPHNQDMREYTLEPIYDAHGGLKGYRRINTKHNAEGCVGDKSAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GDD8</accession>
    <name>A0A836GDD8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histone deacetylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_05930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063633.1">
        <property type="nucleotide sequence ID" value="XM_067207860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GDD8"/>
    <dbReference type="SMR" id="A0A836GDD8"/>
    <dbReference type="GeneID" id="92361794"/>
    <dbReference type="KEGG" id="loi:92361794"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004407">
        <property type="term" value="F:histone deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="HDAC_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF4">
        <property type="entry name" value="DEACETYLASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="2">
        <location>
            <begin position="118"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Histone deacetylase" evidence="2">
        <location>
            <begin position="463"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5479922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="628" mass="67431" checksum="A91046D91E3411D7" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GE28</accession>
    <name>A0A836GE28_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060911.1">
        <property type="nucleotide sequence ID" value="XM_067205359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GE28"/>
    <dbReference type="GeneID" id="92359293"/>
    <dbReference type="KEGG" id="loi:92359293"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5471794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="530" mass="57083" checksum="D1B17DED0936FC14" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GFX2</accession>
    <name>A0A836GFX2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_02214</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061285.1">
        <property type="nucleotide sequence ID" value="XM_067204248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GFX2"/>
    <dbReference type="SMR" id="A0A836GFX2"/>
    <dbReference type="GeneID" id="92358182"/>
    <dbReference type="KEGG" id="loi:92358182"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07834">
        <property type="entry name" value="STKc_MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000046">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000660">
        <property type="entry name" value="Mitogen-activated protein kinase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="43"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5472889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="387" mass="44339" checksum="4D7204D12C0F38C0" modified="2021-09-29" version="1">MATNTVGNGSFDSSANAVHLISTQRGRKIYRVRGQSFEVDDSYTLTSVIGHGAYGVVCAALDDRTFQEVAIKRVSRVFEDLIDGRRIWREILLLRILKECGCRNILRLIRVMPPRDPIMEFRDLYMVTDLYDTDLFTIIRQNKCESIELLRRISVRVVRCLADMHSMGMVHRDIKPSNILLRDDKDTGEAIVCDFGLARAGLHKLSEPLDLTDYVVTRWYRPPELLLMCPYSYPVDIWAVGCVMAEYAMQRPLFAGRDYIHQLQFVLSSVPITGVEFIQRSSSSSGLANVNEMAKKYRGTRPLPQLLSRLPKDGLELVMKMLAFEPEKRITARQALEHPFFESVGGPDCEDYPAPPELDLGFDMHAEVSECQLRRAIWDETEFYRKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GGC0</accession>
    <name>A0A836GGC0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosomal protein S5 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_00186</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058376.1">
        <property type="nucleotide sequence ID" value="XM_067202275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GGC0"/>
    <dbReference type="SMR" id="A0A836GGC0"/>
    <dbReference type="GeneID" id="92356209"/>
    <dbReference type="KEGG" id="loi:92356209"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_uS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_uS5_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S5 DRBM" evidence="1">
        <location>
            <begin position="149"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Small ribosomal subunit protein uS5 C-terminal" evidence="2">
        <location>
            <begin position="220"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5464745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="431" mass="49048" checksum="1DE30F0706B5BC07" modified="2021-09-29" version="1">MLCPTCRVAKNLTSFAAKGTMRGGIPRIYYTWMKPGSATRRRFEKMRNPFVNLETGTSLYFRDTRDSAEAVAHAADSKGLKGMDNGVDLYNEYKIVPDLYPEGFQWKHKLNTEYNQWRSNTWLTPELIPQEHRGRFLCNFQLNIVAYDMRVVKFSPKDHRQWIYCVLYVGSGKGIAGFGRAVAPSTQEARSEAIREAFANIIAVDLEQEGPMYPVRVNADGARVLLYPARRIVANFRVADILCAFGFQNAGCKINLKASNNPKAPTHTVEGVFEAVKALRSVSEIAASRGKVPHSLVYNMYPYLEEMRRRKGMMAMHPPGKDGIFMPDRVVDNRMPDHLKKGYYDDVYWKDFFAGSKEQLNEPKMGLRGDELRAQLEESQGPTVKRSKRRTLDDVLRRLGKTSKDLGALQVVNPRLDAKLPTHVKCNYLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GGT7</accession>
    <name>A0A836GGT7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA-editing substrate-binding complex 6 protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_00497</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058676.1">
        <property type="nucleotide sequence ID" value="XM_067202575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GGT7"/>
    <dbReference type="SMR" id="A0A836GGT7"/>
    <dbReference type="GeneID" id="92356509"/>
    <dbReference type="KEGG" id="loi:92356509"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23735">
        <property type="entry name" value="RESC6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058917">
        <property type="entry name" value="RESC6_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26188">
        <property type="entry name" value="RESC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA-editing substrate-binding complex 6 protein" evidence="2">
        <location>
            <begin position="987"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="730"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1206"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="747"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1217"/>
            <end position="1228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5465045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1237" mass="133450" checksum="73F2107B2293B918" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GGV1</accession>
    <name>A0A836GGV1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cullin family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_03973</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061902.1">
        <property type="nucleotide sequence ID" value="XM_067205965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GGV1"/>
    <dbReference type="SMR" id="A0A836GGV1"/>
    <dbReference type="GeneID" id="92359899"/>
    <dbReference type="KEGG" id="loi:92359899"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cullin family profile" evidence="4">
        <location>
            <begin position="458"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5474796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="771" mass="86033" checksum="1C5CBBFF55FD474B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GH47</accession>
    <name>A0A836GH47_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061552.1">
        <property type="nucleotide sequence ID" value="XM_067205615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GH47"/>
    <dbReference type="GeneID" id="92359549"/>
    <dbReference type="KEGG" id="loi:92359549"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000516">
        <property type="entry name" value="Thioredoxin_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5473549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="446" mass="46534" checksum="F375C365C7CDBDD4" modified="2021-09-29" version="1">MYTGVSSVFAACATFGALRGNWRTHVANSWVAALCSGLRTPSCACLASHPAAALVTSTHACLLGSSVMVGATAPDREEPRGRQNGASVQRRLRCTEASSPRRIKTVLTEQHMKGKPLLRAGTSRVVPRRTWMSDLASSGAVATRSEMAGDADMAPLFDGTLQHAGRDASTAEPHVGVASSTDTAGQVPSSPAAGPTYDSPPSPPPTTGSLTAMPPTLVFSFRGNPHELQERLRGAKALVFFYKASCAPCAVIRSKLFHAVGGDGVGGAGATATPPTSTMLTTRVEESCGLPPPPLAHLLQQHEPERLTGAPTAAPVAAYREATETAAIGVTTSSPGSPSITMTVEDQKSCAVASRFLDDVVKPLPHSVILLTVDTNANAEVTALHDIRSLPTFMAYRNGCIVGRFEGSHAEEINKLVDLLTEDSPEAGLTIDHGNLSQRKQQGASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GIJ8</accession>
    <name>A0A836GIJ8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058955.1">
        <property type="nucleotide sequence ID" value="XM_067203264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GIJ8"/>
    <dbReference type="SMR" id="A0A836GIJ8"/>
    <dbReference type="GeneID" id="92357198"/>
    <dbReference type="KEGG" id="loi:92357198"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5466065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="39475" checksum="AE35F7485CD1E567" modified="2021-09-29" version="1">MAFSVHARAFVPSSAAYAPSGANEQTAGATSTKDCVCMTFYENGKCSYDSHCAHAHHFYELRTETQIKLLRSVPAESIPAHFFGVSRSQGEMLTALDFALPKASTAAFGLLSPIESGEAERTVSTRRRPPGKDRHLVMSHIGPQPPPLDTASLSSRTSSTVDCLHVGETRLSKGLSSPTAAAFAVGTATATAADGAAFKMHLPLRCRYPHRSIPGTYYDVLALPRDALLGDIIAKYRAWQKDGFKRMRQVDPVGAEAVDRMIVEARNVLGNPILRAAYDQQLPSAPLKQQSWAAASCGAGLTSTSTSPSKYHAQGQSSTTSSTSEAHYKLDESHKRLGHSSSSSSLYHADHAAPMVTLSTLHCGESIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GJ89</accession>
    <name>A0A836GJ89_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PHF5-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_00312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PHF5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058499.1">
        <property type="nucleotide sequence ID" value="XM_067202398.1"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A836GJ89"/>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
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                <person name="Al-Salem W.S."/>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        <source>
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</entry>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Bates M.D."/>
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                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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</entry>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL20 family.</text>
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    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </evidence>
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    </evidence>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG5483104.1"/>
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    </dbReference>
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    <dbReference type="KEGG" id="loi:92363151"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5483104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="125" mass="13615" checksum="39ED3164186B0D1F" modified="2021-09-29" version="1">MSCIAKCGGYRSLRAECAREPCMSSGMCTLLDPGVSDCAAWCCTSRSGYVFFLVVFFCAGTFSLCASYYLHRLHQINVEGGAVQESGEAVVVTQPPTEEEMMAARRKKRTAVVDPALLKELESKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="4">Methyltransferase</fullName>
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        <name evidence="2" type="ORF">LSCM4_00776</name>
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        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Metakinetoplastina</taxon>
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            <taxon>Trypanosomatidae</taxon>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059500.1">
        <property type="nucleotide sequence ID" value="XM_067202850.1"/>
    </dbReference>
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    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5467698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="827" mass="90964" checksum="E43E6B8E52D72742" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H105</accession>
    <name>A0A836H105_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA topoisomerase I</fullName>
            <ecNumber evidence="7">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">DNA topoisomerase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_01070</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the type IB topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="7"/>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067203135.1"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A836H105"/>
    <dbReference type="GeneID" id="92357069"/>
    <dbReference type="KEGG" id="loi:92357069"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:DNA replication"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.11.10:FF:000001">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.11.10">
        <property type="entry name" value="DNA Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.15.10">
        <property type="entry name" value="Topoisomerase I, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.41">
        <property type="entry name" value="Yeast DNA topoisomerase - domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013034">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom1"/>
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    <dbReference type="InterPro" id="IPR013030">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001631">
        <property type="entry name" value="TopoI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014711">
        <property type="entry name" value="TopoI_cat_a-hlx-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013500">
        <property type="entry name" value="TopoI_cat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008336">
        <property type="entry name" value="TopoI_DNA-bd_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036202">
        <property type="entry name" value="TopoI_DNA-bd_euk_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013499">
        <property type="entry name" value="TopoI_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051062">
        <property type="entry name" value="Topoisomerase_IB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290:SF3">
        <property type="entry name" value="DNA TOPOISOMERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290">
        <property type="entry name" value="DNA TOPOISOMERASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01028">
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    </dbReference>
    <dbReference type="Pfam" id="PF02919">
        <property type="entry name" value="Topoisom_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment"/>
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    </dbReference>
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        <property type="entry name" value="TOPO_IB_2"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0799">Topoisomerase</keyword>
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        <location>
            <begin position="186"/>
            <end position="629"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="524"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="537"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="549"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
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        <source>
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    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006645"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01382"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5467983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="639" mass="73716" checksum="D717409A174886F0" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H1Q0</accession>
    <name>A0A836H1Q0_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_02639</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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        </source>
    </evidence>
    <sequence length="343" mass="37692" checksum="50E5F852D95253FB" modified="2021-09-29" version="1">MGCAASVRRTPSCGRSQLSFVFSNDTAEAFLPGDAQSTVLAWTRRPVALLGPSQQQPHVPQPPPSARQSLPTTAWLEPKAYLSAATSRFPPPQQKASAGTNSSRSPDWNTPAISTLSPAPLLPGVPPQRVLVHEDELLRADLNTGRCVMMTQSDRSPSSDSVSDRSLGGSTSAQLCQRQKEYQQPQQLQGSLGDPYEVFLSPPMPSSRLREEDTQADLRICRLMRRSLSGELTRMTPWPNQARHAVQSTIFVITTAEDLQAGGSRAVLGPGHADALPMNSLTQNSANDPAYFPVTEQFRLSRFDRRRILKAYREQMRLLPDVTQMPSRLPSSHSRSRSSGQEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H463</accession>
    <name>A0A836H463_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000022">
        <property type="protein sequence ID" value="KAG5479192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063285.1">
        <property type="nucleotide sequence ID" value="XM_067203826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H463"/>
    <dbReference type="SMR" id="A0A836H463"/>
    <dbReference type="GeneID" id="92357760"/>
    <dbReference type="KEGG" id="loi:92357760"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5479192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="384" mass="42816" checksum="C6C21A34A3577914" modified="2021-09-29" version="1">MRRKQYVKASSSHSSLSAPTRRSGLRHSFEERLSPRRFPNTHAMPPLGARNASPGGRDRGVSRTLDSSVMGSLVDTSVSDVPESNPVSLSPQQEALRSRADHLAKRLRQTQAQEVRQRSFLAGEAVARLEDMMRRHVAYVDIAASCAHLQASRHAQAQAKAQQAQRWELRILQDTLSDTVDEEKKRRKDIEQTQLSVRRSLAQLHGAEVQPLQLREAVFRLIRGEEVRRSFLHREETRAVEAMGIPHFTPLSCVSAPAEATVNLGGGGRVAAKQSITELSKLDLMALQRCPFQCAADCPFMPQRIRQLGQRWATAGGSSKKMHGTTASAQRHLRGASPSPVAHSSWQWRASGLQITEVGKQRVRNAMRIRHYSATTKFLPTLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H6V2</accession>
    <name>A0A836H6V2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cytochrome c oxidase assembly factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_07572</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the SCO1/2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000004">
        <property type="protein sequence ID" value="KAG5487891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066088.1">
        <property type="nucleotide sequence ID" value="XM_067209456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H6V2"/>
    <dbReference type="SMR" id="A0A836H6V2"/>
    <dbReference type="GeneID" id="92363390"/>
    <dbReference type="KEGG" id="loi:92363390"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02968">
        <property type="entry name" value="SCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000013">
        <property type="entry name" value="Blast:Protein SCO1 homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003782">
        <property type="entry name" value="SCO1/SenC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017276">
        <property type="entry name" value="Synth_of_cyt-c-oxidase_Sco1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151:SF5">
        <property type="entry name" value="AT19154P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151">
        <property type="entry name" value="ELECTRON TRANSPORT PROTIN SCO1/SENC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02630">
        <property type="entry name" value="SCO1-SenC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037736">
        <property type="entry name" value="SCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="10">
        <location>
            <begin position="170"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR037736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037736-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR603782-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5487891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="309" mass="34919" checksum="62CF7431F812AB63" modified="2021-09-29" version="1">MHRSPLSRAVRWAPMTVPHRSGALLRLQRPPCIMTRDLLVSTGAVAADLVDTTTTPLAHSRRAFREKGAANPNNADAAETAELEKDRQALRKYGMFGGFALLCMATLWYGSRQAKQRYFGAEGSARVSVETRGRPALGGPFVLVNTKGEPVSQAEFLGSWAFFYFGFTHCPEICPVELNRMSHVVDAVHATRPQERIAPLFVSCDPRRDSLGAIEEYLSVFHPDFIGLVGTPKQVNDACRSYRIYYSVPADEDAEQEDYLIDHSIAIFLFDPQGRFVDFFGNRYDEREIKERVLHYMSEYAKDPTWTNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H7E7</accession>
    <name>A0A836H7E7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_08155</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000002">
        <property type="protein sequence ID" value="KAG5488176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066224.1">
        <property type="nucleotide sequence ID" value="XM_067210026.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92363960"/>
    <dbReference type="KEGG" id="loi:92363960"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000933">
        <property type="entry name" value="ABC transporter A family member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001592">
        <property type="entry name" value="ATP-binding cassette protein subfamily A, member 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056264">
        <property type="entry name" value="R2_ABCA1-4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF262">
        <property type="entry name" value="TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23321">
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    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="526"/>
            <end position="550"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="926"/>
            <end position="944"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="987"/>
            <end position="1004"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1011"/>
            <end position="1033"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="1105"/>
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            <begin position="1991"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="2033"/>
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            <begin position="2072"/>
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        <location>
            <begin position="2104"/>
            <end position="2124"/>
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    </feature>
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        <location>
            <begin position="2144"/>
            <end position="2164"/>
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    </feature>
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        <location>
            <begin position="2176"/>
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            <begin position="1233"/>
            <end position="1466"/>
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        <location>
            <begin position="2334"/>
            <end position="2564"/>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
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        </recommendedName>
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        <name evidence="6" type="ORF">LSCM4_07063</name>
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        <name type="scientific">Leishmania orientalis</name>
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    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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            <name>Zn(2+)</name>
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        <text evidence="2">Belongs to the eukaryotic ribosomal protein eS27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000018">
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="KAG5481352.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="150" mass="16616" checksum="E753ADF6A6FF9420" modified="2021-09-29" version="1">MCCLRIPHTHFTIANAAAAASTACLLKHIHQVGLSRLIILASSRLIRKNKEHTSAVVGSSNLSTMGFFDADLSYPTVRTERMKHKRRRLVQGPNSYFMDVSCPRCRQVTVVYSHATTSVECKGCSKKLCRPTGGKALLVEGCGYRRKPDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H8L4</accession>
    <name>A0A836H8L4_9TRYP</name>
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        <recommendedName>
            <fullName evidence="5">Pescadillo homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_07540</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the pescadillo family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000004">
        <property type="protein sequence ID" value="KAG5487859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067209424.1"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A836H8L4"/>
    <dbReference type="GeneID" id="92363358"/>
    <dbReference type="KEGG" id="loi:92363358"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17709">
        <property type="entry name" value="BRCT_pescadillo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000108">
        <property type="entry name" value="Pescadillo homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03028">
        <property type="entry name" value="Pescadillo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010613">
        <property type="entry name" value="PES"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12221">
        <property type="entry name" value="PESCADILLO - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12221:SF6">
        <property type="entry name" value="PESCADILLO HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06732">
        <property type="entry name" value="Pescadillo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="BRCT" evidence="7">
        <location>
            <begin position="317"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="552"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="644"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="294"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="644"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5487859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="671" mass="77083" checksum="6EB40B62B31AB771" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H974</accession>
    <name>A0A836H974_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FACT complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LSCM4_03444</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the FACT complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the peptidase M24 family. SPT16 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061384.1">
        <property type="nucleotide sequence ID" value="XM_067205447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H974"/>
    <dbReference type="SMR" id="A0A836H974"/>
    <dbReference type="GeneID" id="92359381"/>
    <dbReference type="KEGG" id="loi:92359381"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035101">
        <property type="term" value="C:FACT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000017">
        <property type="entry name" value="FACT complex subunit SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.150:FF:000006">
        <property type="entry name" value="Transcription factor-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.210:FF:000004">
        <property type="entry name" value="Transcription factor-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000021">
        <property type="entry name" value="Transcription factor-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.210">
        <property type="entry name" value="FACT complex subunit Spt16p/Cdc68p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056595">
        <property type="entry name" value="Fact-SPT16_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013953">
        <property type="entry name" value="FACT_SPT16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040258">
        <property type="entry name" value="Spt16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13980">
        <property type="entry name" value="CDC68 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13980:SF15">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24824">
        <property type="entry name" value="PH_SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08644">
        <property type="entry name" value="SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01286">
        <property type="entry name" value="SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FACT complex subunit SPT16 middle" evidence="12">
        <location>
            <begin position="535"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="domain" description="Histone chaperone RTT106/FACT complex subunit SPT16-like middle" evidence="13">
        <location>
            <begin position="797"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="443"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="911"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="456"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="922"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="982"/>
            <end position="1003"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG5473381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1047" mass="115378" checksum="CBB4EAAA468011E3" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HAQ3</accession>
    <name>A0A836HAQ3_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_05390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5477993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062900.1">
        <property type="nucleotide sequence ID" value="XM_067207332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HAQ3"/>
    <dbReference type="GeneID" id="92361266"/>
    <dbReference type="KEGG" id="loi:92361266"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018527">
        <property type="entry name" value="Rubredoxin_Fe_BS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00202">
        <property type="entry name" value="RUBREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="415"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="637"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="637"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="677"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5477993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="938" mass="99724" checksum="950900CF8442F837" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HB63</accession>
    <name>A0A836HB63_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_06485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000019">
        <property type="protein sequence ID" value="KAG5480915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063916.1">
        <property type="nucleotide sequence ID" value="XM_067208404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HB63"/>
    <dbReference type="SMR" id="A0A836HB63"/>
    <dbReference type="GeneID" id="92362338"/>
    <dbReference type="KEGG" id="loi:92362338"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054179">
        <property type="entry name" value="PSD13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035298">
        <property type="entry name" value="PSMD13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10539">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10539:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22037">
        <property type="entry name" value="PSD13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0647">Proteasome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="2">
        <location>
            <begin position="199"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5480915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="412" mass="46564" checksum="B4E28DF4AE24211A" modified="2021-09-29" version="1">MSTPEARAQIYLVNLRGKLEERNNASAAATVSRALDCFERRFWYELSNELLQLIRDPFVLEDAYELYADVIIAVRADISPIAYVMIVRSVCFAPQSTTQKALELVEGACASLIHSSSEQGHYAALCIRALLLLESTSAEDSAVLAAVPGSPPHTARKLLEQTEMYLHGLKMHEVEPVLVALYGMARGRDYEIRRQHTSYYKNAFDIVIFLEKADLPMRDEDVTALAYKTVVAGLLSDKIFNFGKLLNFDQFVSRLQRESCPQQWALEMMRLCNEGDVVSFEAFFRQHQQQISQEPQLVSASATLHRKVRLMALLHLIFYTPLSERTFTFHAVAQRCGVPDSAAEPLLLEALAHGIIKGRMDGLKEEVHITWVESRVLSLEEVKALAQHVAKWREQVVELTNSVKEMAKKIPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HD02</accession>
    <name>A0A836HD02_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_01751</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000022">
        <property type="protein sequence ID" value="KAG5479163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063256.1">
        <property type="nucleotide sequence ID" value="XM_067203797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HD02"/>
    <dbReference type="SMR" id="A0A836HD02"/>
    <dbReference type="GeneID" id="92357731"/>
    <dbReference type="KEGG" id="loi:92357731"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="483"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="130"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="497"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="518"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5479163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="556" mass="63998" checksum="32B5077C28C8EA49" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HDN0</accession>
    <name>A0A836HDN0_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_04000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061929.1">
        <property type="nucleotide sequence ID" value="XM_067205992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HDN0"/>
    <dbReference type="GeneID" id="92359926"/>
    <dbReference type="KEGG" id="loi:92359926"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5474823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="217" mass="24105" checksum="EADAA140B5A9B77A" modified="2021-09-29" version="1">MRVFSFMEKIYTTGTAPVNTSEDVWVEGKRYPAHMVGRAIVNHPTPILLTVALSLVLFVIGCAKIQSALFCSLDDYQIRSTIGVRRDALKAKSALDGWGFALPGAYRLSDSVNLSHPRTLVQGTVELRVNVDLQGLVSYADEVNMTPAERDAYANMLHPDLLSIYRTAERHVTQLAGYESVCFTSDLRNGQLNHIYPTCAPVSSVTQYVYPFWTGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HF18</accession>
    <name>A0A836HF18_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hereditary spastic paraplegia protein strumpellin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_04242</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the strumpellin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062168.1">
        <property type="nucleotide sequence ID" value="XM_067206231.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92360165"/>
    <dbReference type="KEGG" id="loi:92360165"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071203">
        <property type="term" value="C:WASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140285">
        <property type="term" value="P:endosome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051125">
        <property type="term" value="P:regulation of actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019393">
        <property type="entry name" value="WASH_strumpellin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15691">
        <property type="entry name" value="WASH COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15691:SF6">
        <property type="entry name" value="WASH COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10266">
        <property type="entry name" value="Strumpellin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5475660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1292" mass="143308" checksum="226C75BE14E58ACA" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HG33</accession>
    <name>A0A836HG33_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_04408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062602.1">
        <property type="nucleotide sequence ID" value="XM_067206393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HG33"/>
    <dbReference type="GeneID" id="92360327"/>
    <dbReference type="KEGG" id="loi:92360327"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677">
        <property type="entry name" value="ARSENITE INDUCUBLE RNA ASSOCIATED PROTEIN AIP-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677:SF38">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5477191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="666" mass="69310" checksum="D5561E2E45CE316C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HGP2</accession>
    <name>A0A836HGP2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_04965</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000014">
        <property type="protein sequence ID" value="KAG5483810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064749.1">
        <property type="nucleotide sequence ID" value="XM_067206940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HGP2"/>
    <dbReference type="SMR" id="A0A836HGP2"/>
    <dbReference type="GeneID" id="92360874"/>
    <dbReference type="KEGG" id="loi:92360874"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051727">
        <property type="entry name" value="DnaJ_C3_Co-chaperones"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44140">
        <property type="entry name" value="LD25575P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44140:SF2">
        <property type="entry name" value="LD25575P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="269"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="445"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="513"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="400"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="524"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5483810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="578" mass="64347" checksum="C5FD94530DEE0C9E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HHD4</accession>
    <name>A0A836HHD4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sn-1-specific diacylglycerol lipase</fullName>
            <ecNumber evidence="14">3.1.1.116</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">LSCM4_07018</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33275"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17389"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.116"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:33276"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.116" evidence="14"/>
    <dbReference type="EMBL" id="JAFHLR010000018">
        <property type="protein sequence ID" value="KAG5481308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063987.1">
        <property type="nucleotide sequence ID" value="XM_067208924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HHD4"/>
    <dbReference type="SMR" id="A0A836HHD4"/>
    <dbReference type="GeneID" id="92362858"/>
    <dbReference type="KEGG" id="loi:92362858"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
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        <property type="entry name" value="AB_hydrolase_fold"/>
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        <property type="entry name" value="DIACYLGLYCEROL LIPASE-ALPHA"/>
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            <dbReference type="Pfam" id="PF01764"/>
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            <dbReference type="EMBL" id="KAG5481308.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
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    <sequence length="708" mass="78761" checksum="4FBB862E058E6422" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <begin position="131"/>
            <end position="148"/>
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        </location>
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            <dbReference type="EMBL" id="KAG5486482.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836HJZ3_9TRYP</name>
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        <recommendedName>
            <fullName evidence="4">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">LSCM4_08067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </location>
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        <location>
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            <end position="149"/>
        </location>
    </feature>
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            <end position="230"/>
        </location>
    </feature>
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        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="667"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="889"/>
            <end position="913"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5487622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HMH2</accession>
    <name>A0A836HMH2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="4" type="ORF">LSCM4_06290</name>
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    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000007">
        <property type="protein sequence ID" value="KAG5486825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="GeneID" id="92362148"/>
    <dbReference type="KEGG" id="loi:92362148"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0010945">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="CoAse"/>
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    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992:SF44">
        <property type="entry name" value="NUDIX HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
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    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="484"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="127"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="612"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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                <person name="Bates M.D."/>
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                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="23" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="23" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
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                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">LSCM4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 24">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. eIF4A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="JAFHLR010000001">
        <property type="protein sequence ID" value="KAG5488297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFHLR010000001">
        <property type="protein sequence ID" value="KAG5488298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066344.1">
        <property type="nucleotide sequence ID" value="XM_067210243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HVB8"/>
    <dbReference type="SMR" id="A0A836HVB8"/>
    <dbReference type="GeneID" id="92364177"/>
    <dbReference type="KEGG" id="loi:92364177"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17939">
        <property type="entry name" value="DEADc_EIF4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000849">
        <property type="entry name" value="ATP-dependent RNA helicase DBP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000031">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="20">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="57"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="241"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="15">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAG5488297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAG5488298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="403" mass="45366" checksum="81B54B92E1AADD0F" modified="2021-09-29" version="1">MSHQDKVAPQDQDSFLDDQPGIRPIPSFDDMPLHQNLLRGIYSYGFEKPSSIQQRAIAPFTRGGDIIAQAQSGTGKTGAFSIGLLQRLDFRHNLIQGLVLSPTRELALQTAEVISRIGEFLSNSSKFCETFVGGTRVQDDLRKLQAGVIVAVGTPGRVSDVIKRGALRTESLRVLVLDEADEMLSQGFADQIYEIFRFLPKDIQVALFSATMPEEVLELTKKFMRDPVRILVKRESLTLEGIKQFFIAVEEEHKLDTLMDLYETVSIAQSVIFANTRRKVDWIAEKLNQSNHTVSSMHAEMPKSDRERVMNTFRSGSSRVLVTTDLVARGIDVHHVNIVINFDLPTNKENYLHRIGRGGRYGRKGVAINFVTEKDVELLHEIEAHYHTQIDELPVDFAAYLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HWQ0</accession>
    <name>A0A836HWQ0_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_06639</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000010">
        <property type="protein sequence ID" value="KAG5485681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065265.1">
        <property type="nucleotide sequence ID" value="XM_067208554.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92362488"/>
    <dbReference type="KEGG" id="loi:92362488"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34993">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34993:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="305"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="518"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="551"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="578"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1950"/>
            <end position="1974"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="630"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="671"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="739"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="880"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1063"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1114"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1656"/>
            <end position="1767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1839"/>
            <end position="1901"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="634"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="681"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="739"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="884"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1128"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1138"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1696"/>
            <end position="1707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1740"/>
            <end position="1756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1842"/>
            <end position="1854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1869"/>
            <end position="1879"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5485681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="2095" mass="228215" checksum="84A48A4EA265CB99" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836I029</accession>
    <name>A0A836I029_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_06564</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000010">
        <property type="protein sequence ID" value="KAG5485608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065192.1">
        <property type="nucleotide sequence ID" value="XM_067208481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836I029"/>
    <dbReference type="SMR" id="A0A836I029"/>
    <dbReference type="GeneID" id="92362415"/>
    <dbReference type="KEGG" id="loi:92362415"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.110.10:FF:000025">
        <property type="entry name" value="MORN repeat, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052849">
        <property type="entry name" value="MORN_repeat_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46917">
        <property type="entry name" value="MORN REPEAT-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46917:SF1">
        <property type="entry name" value="MORN REPEAT-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="206"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5485608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="221" mass="23440" checksum="2981107BF016F614" modified="2021-09-29" version="1">MPAKKKEVKAEEPLFVDEEGSFVHEAEGARYKGGIRRYARPGGADASGTAVSPAKSSRSRSASSPGKGGATLVQPSAGGAAPSMAAANDAPVFRHGRGVYTCPSFTYAGDWVEDEMHGSGQLAFVDSGNVYEGEFYHGCFSGEGTYRWRDGAMYCGQWRSNRMHGEGVYTDVNGHVWKGRYYNGTGPGLIRLYPSLERVVGPDASSPESTAVNAGTTAARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836I0Y9</accession>
    <name>A0A836I0Y9_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_07391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000008">
        <property type="protein sequence ID" value="KAG5486460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065526.1">
        <property type="nucleotide sequence ID" value="XM_067209283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836I0Y9"/>
    <dbReference type="SMR" id="A0A836I0Y9"/>
    <dbReference type="GeneID" id="92363217"/>
    <dbReference type="KEGG" id="loi:92363217"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5486460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="352" mass="39609" checksum="6752388F45760471" modified="2021-09-29" version="1">MLRISAAGWAPLQASRPRLFFSWLSQSSKHRGSAAATRRTNAKETFISEAAMGLGGGDVGQPMANEAFEALEGTGASTASYRQAGVNGIGQRGVGHSQSFHAGGSGAPGSTVPKQPIDDILIERAAHLTGPNRRPLSYDLEIHRAARAREATQMQASEEHLRQFDEQNMPRNPHDPNRERASWEFTPTPEHKSLVLLLYRNVLKGLVNYKSVRRRSMIAYARMCFRRRAMATEKLLIDECIEECRRSIYVLEKHHQFTKTGTYEFDSMTLPKDTGQDVKTYMEEVYDPEQSRMQFQNFTDVQPGREHLHRQGLGPTSGPHHWKDQRSSEGFKVEIRDEDRALRPPPPPGMAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836I445</accession>
    <name>A0A836I445_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_08259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000003">
        <property type="protein sequence ID" value="KAG5488035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066162.1">
        <property type="nucleotide sequence ID" value="XM_067210129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836I445"/>
    <dbReference type="SMR" id="A0A836I445"/>
    <dbReference type="GeneID" id="92364063"/>
    <dbReference type="KEGG" id="loi:92364063"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03114">
        <property type="entry name" value="MMAA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005129">
        <property type="entry name" value="GTPase_ArgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00750">
        <property type="entry name" value="lao"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23408:SF3">
        <property type="entry name" value="METHYLMALONIC ACIDURIA TYPE A PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23408">
        <property type="entry name" value="METHYLMALONYL-COA MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03308">
        <property type="entry name" value="MeaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5488035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="335" mass="37165" checksum="049F641C09212AE2" modified="2021-09-29" version="1">MKSHAPRPRIPQRIPVEDIINGNRRALSKAITLAESSHPADSSRLSILLHEIHQTATVRTVPRLALSGSPGSGKSCLLDALGYYLCEKKNMRVGVLAVDPSSTITHGSILGDKTRMEKLGSHRNSYIRPSPSGGHLGGVTSRAWEVLEIFEAGSFDVVFVETVGVGQSETQCKDLTDMMILLVPPASGDELQGIKKGIVEVADMVVVTKNDGDRKLLVQQTTSAYTRAVMYTEAKQGFEKPVIAVSAEEGTNVPELWEAIMKMWSARVESGHISRLRRAQSAQHFYNYYEMELLARARRMASLELQKAAHRVWEHEMTPREAGDIMVRRTLREHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836K7M8</accession>
    <name>A0A836K7M8_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059079.1">
        <property type="nucleotide sequence ID" value="XM_067203388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836K7M8"/>
    <dbReference type="SMR" id="A0A836K7M8"/>
    <dbReference type="GeneID" id="92357322"/>
    <dbReference type="KEGG" id="loi:92357322"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="125"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5466189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="578" mass="66780" checksum="5A4586264BB87536" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KBB8</accession>
    <name>A0A836KBB8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_02858</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060430.1">
        <property type="nucleotide sequence ID" value="XM_067204878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KBB8"/>
    <dbReference type="SMR" id="A0A836KBB8"/>
    <dbReference type="GeneID" id="92358812"/>
    <dbReference type="KEGG" id="loi:92358812"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001511">
        <property type="entry name" value="Serine/threonine-protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000698">
        <property type="entry name" value="Serine/threonine-protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:001105">
        <property type="entry name" value="Serine/threonine-protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051131">
        <property type="entry name" value="NEK_Ser/Thr_kinase_NIMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899">
        <property type="entry name" value="CAMK FAMILY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899:SF6">
        <property type="entry name" value="SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="144"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="10">
        <location>
            <begin position="537"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="30"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5470164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="655" mass="70524" checksum="4FFE670BB603CABE" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KBJ7</accession>
    <name>A0A836KBJ7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S Ribosomal protein L36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_01367</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059112.1">
        <property type="nucleotide sequence ID" value="XM_067203421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KBJ7"/>
    <dbReference type="SMR" id="A0A836KBJ7"/>
    <dbReference type="GeneID" id="92357355"/>
    <dbReference type="KEGG" id="loi:92357355"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1760:FF:000001">
        <property type="entry name" value="60S ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1760">
        <property type="entry name" value="60S ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000509">
        <property type="entry name" value="Ribosomal_eL36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038097">
        <property type="entry name" value="Ribosomal_eL36_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10114">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01158">
        <property type="entry name" value="Ribosomal_L36e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5466222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="105" mass="11997" checksum="88FB18CFEC4B1373" modified="2021-09-29" version="1">MSAPTPRTGIIAGFNKGHTTTRRPRQPSPNDRFAVPHKRLRAVKAIIADLVGFSPLEKRVQEFLRVGKEKRALKYCKKRLGDFTAAKKKRSKMEEALRHATKKHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KDU4</accession>
    <name>A0A836KDU4_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_01959</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Al-Salem W.S."/>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Al-Salem W.S."/>
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            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="protein sequence ID" value="KAG5467840.1"/>
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        <source>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
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                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
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            </authorList>
            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <comment type="cofactor">
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    <comment type="cofactor">
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        </cofactor>
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    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992:SF11">
        <property type="entry name" value="MITOCHONDRIAL COENZYME A DIPHOSPHATASE NUDT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="7">
        <location>
            <begin position="66"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5464588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="321" mass="34263" checksum="597A4CBAC712027C" modified="2021-09-29" version="1">MNRATAAAARLPQSTQGWVTLLQKALDLPIESVALPSHFYLHTLSNGTALTTGFSPLKPPVRAVSPSQYAVLVLLSPATTRSDFQDMCVTLTKRSQTMGSHKGEMSFPGGRVEADETPCDAAQREALEEVGLFPSEYEIIGSLTPIATKRHGAHVTPFVAVATKPAQPHCASPDEVASVHYLHMSGLLLNASTRHARVIKYQSLTSHCPCFFPCFFASPAQTVLSPAVCRSPKATLVADDCGFDPMLPEDFPGEMVWGLTSFVTCELVARVAKIITDAEGAESAAAVNALLTPSNVVARDPLVNSLKCAEFSTRPVLDSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KH72</accession>
    <name>A0A836KH72_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061053.1">
        <property type="nucleotide sequence ID" value="XM_067204016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KH72"/>
    <dbReference type="SMR" id="A0A836KH72"/>
    <dbReference type="GeneID" id="92357950"/>
    <dbReference type="KEGG" id="loi:92357950"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5472657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="325" mass="36790" checksum="87080F20B9093FFE" modified="2021-09-29" version="1">MSGNKDTYTFQYGELKKGQIYALAMARVADNFVHSSFHDSPNYEKLLISIFEHISKDPSMDDKMLQALENALMTRQNTVLKEARDNDKDRKKFVFEKRTTGRDPNEDSDSDAEEVSAEELAARKAAEEAEEKRKEQEWLKAQERYAALQQQKLENEERLRAQARQVDIDAFERQLKNRGAVLLDSGLPAKKKGGKGGSKAGQLSAEDAAKMKEEVALIMKEKERLDTVLHTSDEDLPATLEEARRSLAEYKQKAATIGEPAAPAKEMSKGEVTQLQQKLTKLTMDKNRRALQLKAMEPHPLRDELVSVLEQRDALAVKVERSEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KHF0</accession>
    <name>A0A836KHF0_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062367.1">
        <property type="nucleotide sequence ID" value="XM_067207064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KHF0"/>
    <dbReference type="GeneID" id="92360998"/>
    <dbReference type="KEGG" id="loi:92360998"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5476134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="501" mass="54818" checksum="B1B167E9FF8060F0" modified="2021-09-29" version="1">MRHMRGSCSTSRLVCAPQTSMWPPVAQTMLSRYLGVGEMLLCVTPETRRCKSITSLPSSVWPRGELLVERKARLMAERAGARAANVSRLRELLQVFPAKERGKLFPKPQPHLRRDVWPLATPAEPPSQPPSASPRMKRSAASDSPRFLSSAVIQAFQKGASRGVAADAQGATGKCGEKQQQGSYYGSPRWYSGPPGTWMDAAYFTAQQSNRWNQLFHDLYYTRNEPTAPLLRCPACAARRLRDSVASPRRAESADSPESCPRTKVQLTSSLSSVWMDPAELQRHLSYTHASELFTPQELQLYNAQVLHELQYSCGLVPAPTCADGKIGAGVASGARKTQPARVILVADVANIELGSPSELLEMLLSPKLRRVFSDFPVAFCATHELFVPVISKVLHTLYQMARLHPASTLHVFFANTSLESGDLLTSSYLNDLLLASPHCAPPPVVLLTGDLQQQRALTELHGAPAHGMGNGGHVHWVKPLTAAQLVVDLYAALECSQCLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KHF2</accession>
    <name>A0A836KHF2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="10">1.2.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_02222</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = (2R)-3-phospho-glyceroyl phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10300"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 10">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.12" evidence="10"/>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061293.1">
        <property type="nucleotide sequence ID" value="XM_067204256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KHF2"/>
    <dbReference type="SMR" id="A0A836KHF2"/>
    <dbReference type="GeneID" id="92358190"/>
    <dbReference type="KEGG" id="loi:92358190"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18126">
        <property type="entry name" value="GAPDH_I_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05214">
        <property type="entry name" value="GAPDH_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000001">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000001">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836">
        <property type="entry name" value="GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836:SF76">
        <property type="entry name" value="GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4 7 10" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding" evidence="11">
        <location>
            <begin position="4"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="13"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="166"/>
            <end position="168"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="227"/>
            <end position="228"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="8">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5472897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="361" mass="39035" checksum="40353CC2A261631E" modified="2021-09-29" version="1">MAPIKVGINGFGRIGRMVFQAICDQNLIGSEIDVVAVVDMSTNADYFAYQMKHDTVHGRPKYTVEAVKSSPSVKTADVLVVNGHRIKCVKAQRNPADLPWSKLGVDYVIESTGLFTDKVKAEGHIKGGAKKVVISAPASGGAKTIVMGVNQHEYSPASHHVVSNASCTTNCLAPIVHVLTKENFGIETGLMTTIHSYTATQKTVDGVSLKDWRGSRAAAVNIIPSTTGAAKAVGMVIPSTKGKLTGMSFRVPTPDVSVVDLTFRAARDTSIQEIDAAIKKASETYMKGILGFTEDELVSADFINDNRSSIYDSKATLQNNLPGEKRFFKIVSWYDNEWGYSHRVVDLLRYMAAKDAAGSKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KHG3</accession>
    <name>A0A836KHG3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_02268</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPO2/CSE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061338.1">
        <property type="nucleotide sequence ID" value="XM_067204301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KHG3"/>
    <dbReference type="SMR" id="A0A836KHG3"/>
    <dbReference type="GeneID" id="92358235"/>
    <dbReference type="KEGG" id="loi:92358235"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005043">
        <property type="entry name" value="XPO2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013713">
        <property type="entry name" value="XPO2_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF8">
        <property type="entry name" value="EXPORTIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03378">
        <property type="entry name" value="CAS_CSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08506">
        <property type="entry name" value="Cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="8">
        <location>
            <begin position="69"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5472942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="975" mass="107976" checksum="2717FD4E841788A1" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KHN9</accession>
    <name>A0A836KHN9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aquaglyceroporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_03734</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061667.1">
        <property type="nucleotide sequence ID" value="XM_067205730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KHN9"/>
    <dbReference type="SMR" id="A0A836KHN9"/>
    <dbReference type="GeneID" id="92359664"/>
    <dbReference type="KEGG" id="loi:92359664"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015254">
        <property type="term" value="F:glycerol channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050363">
        <property type="entry name" value="MIP/Aquaporin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00861">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829">
        <property type="entry name" value="AQUAPORIN OR AQUAGLYCEROPORIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829:SF9">
        <property type="entry name" value="AQUAPORIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="280"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5474561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="309" mass="34338" checksum="64D77FD10D89354E" modified="2021-09-29" version="1">MTQSIHDGEVQVYLGKEDPHEVPMGQDLDEERPQQLEEEKRNFTSQGMWPLYQYRWWLREYIAEFFGSFFLLSFGIGVNATTLFHTGATASYQTNVTFLAVTFGWGFGLAIALFMSMGVSGGHLNPAVTIANCVFGAFPWKKAPGFFLAQLLGSMVGALNVYGLFKSHFDDGHQNLLPHETMASKFSGVFVTYPNVPNGYAVWSEVFNTMALMMGILAVTDSRMTPALNFKPVAVGLLLFVIGLTTGANSGFALNPARDLGPRIITAMLWGSEPFTLYSYYFWIPTFMPFVGALLGMFLYVFFIIPSCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KI23</accession>
    <name>A0A836KI23_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">UDP-glucose:glycoprotein glucosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_03657</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061590.1">
        <property type="nucleotide sequence ID" value="XM_067205653.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836KI23"/>
    <dbReference type="GeneID" id="92359587"/>
    <dbReference type="KEGG" id="loi:92359587"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003980">
        <property type="term" value="F:UDP-glucose:glycoprotein glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06432">
        <property type="entry name" value="GT8_HUGT1_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000283">
        <property type="entry name" value="UDP-glucose:glycoprotein glucosyltransferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040497">
        <property type="entry name" value="Glyco_transf_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009448">
        <property type="entry name" value="UDP-g_GGtrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040693">
        <property type="entry name" value="UGGT_TRXL_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040694">
        <property type="entry name" value="UGGT_TRXL_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040692">
        <property type="entry name" value="UGGT_TRXL_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226">
        <property type="entry name" value="UDP-GLUCOSE GLYCOPROTEIN:GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226:SF0">
        <property type="entry name" value="UDP-GLUCOSE:GLYCOPROTEIN GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18404">
        <property type="entry name" value="Glyco_transf_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18400">
        <property type="entry name" value="Thioredoxin_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18401">
        <property type="entry name" value="Thioredoxin_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18402">
        <property type="entry name" value="Thioredoxin_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06427">
        <property type="entry name" value="UDP-g_GGTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="8">
        <location>
            <begin position="58"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="9">
        <location>
            <begin position="437"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="10">
        <location>
            <begin position="602"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="domain" description="Glucosyltransferase 24 catalytic" evidence="11">
        <location>
            <begin position="1502"/>
            <end position="1777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="170"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5473587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1786" mass="195513" checksum="F586E9B91225B9B6" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KI69</accession>
    <name>A0A836KI69_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_01690</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059428.1">
        <property type="nucleotide sequence ID" value="XM_067203737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KI69"/>
    <dbReference type="SMR" id="A0A836KI69"/>
    <dbReference type="GeneID" id="92357671"/>
    <dbReference type="KEGG" id="loi:92357671"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072380">
        <property type="term" value="C:TRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047150">
        <property type="entry name" value="SGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005344">
        <property type="entry name" value="TMEM33/Pom33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831">
        <property type="entry name" value="LD24721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831:SF2">
        <property type="entry name" value="LD24721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03661">
        <property type="entry name" value="TMEM33_Pom33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="251"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="6"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="73"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5466538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="382" mass="42617" checksum="E4A6A0C2E3AF8CFE" modified="2021-09-29" version="1">MVNALAEELKARGNEAFAAKRFEDAIVLYDKAIEMDSTNFIYYNNRAAAYHELKNYAKAIEDANTSIAIEDNAKAHARIGAALWAQMKYREAKDAFEVAAAMDPSKKSIKDSIQALEQLINPIAPTSAYAHRRGVPHPYEYARAAAAANAAVPTFGGEFVSVDTGSIGLVLDVAVLVLAALQVLASLFVPSMASTLWGYILLITMCQQALVMRVRNLLQLKMDVLNSWMTHFSSLLFTLCFFAQLTRVRPIIFMPVFIAAYSMLDLVYKRQQVAALLGPLYRFIAPYVKQADDAKDTIRIFTATVEALLMFTVMFSGGAFFTTAYLQYAKCRYNHDGYVRLAFKGLRMNATRMTTSSFMPQAVDKYAQKFFDLLHKIACQPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KIY8</accession>
    <name>A0A836KIY8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">HIT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_03765</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the BCD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061698.1">
        <property type="nucleotide sequence ID" value="XM_067205761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KIY8"/>
    <dbReference type="SMR" id="A0A836KIY8"/>
    <dbReference type="GeneID" id="92359695"/>
    <dbReference type="KEGG" id="loi:92359695"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070761">
        <property type="term" value="C:pre-snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048254">
        <property type="term" value="P:snoRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23023">
        <property type="entry name" value="zf-HIT_BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051639">
        <property type="entry name" value="BCD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057721">
        <property type="entry name" value="BCD1_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483:SF3">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25790">
        <property type="entry name" value="BCD1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="11">
        <location>
            <begin position="136"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="10">
        <location>
            <begin position="550"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="10">
        <location>
            <begin position="577"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="8">
        <location>
            <begin position="550"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="8">
        <location>
            <begin position="577"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="385"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="523"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="395"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="530"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5474592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="665" mass="74062" checksum="0D939729EEA38F4B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KJL1</accession>
    <name>A0A836KJL1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_01172</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5468083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059885.1">
        <property type="nucleotide sequence ID" value="XM_067203235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KJL1"/>
    <dbReference type="GeneID" id="92357169"/>
    <dbReference type="KEGG" id="loi:92357169"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000778">
        <property type="entry name" value="RNA-binding protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001255">
        <property type="entry name" value="RNA-binding protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="47"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="132"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="215"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5468083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="390" mass="42877" checksum="D09B653D8F5507FD" modified="2021-09-29" version="1">MEPKGAAMGGYKPSLRVDIGSADNAKDESSNATGSSSQKPLTPHVSTNIFVAGIPSTWDDDALRERYKEFGEIVSTKVVKNRHFGFVMFRKADSAHAAINATHLTQPTPNCANVLHVSIAMHDEGLDDQPNDRLFIRGLPQWATKEHLRQMFSPYGVIKECAVLMNPLGQCKGSGFVQFSSQQEATAAIQARDSISMDNWPHQLEVKYSESAEVRQMRQERNRNRQRHWLPSPQYRGGNTPSSLPASYPGFSPPLSLIPSPQAFPVMSAMPFPMVYPPTPPTTGAPTQIVYPQPIYQTMPPFYSASAVVIPAPMPLPQKGDLHFSGPPLTEELLRFLLQSYGEVEAVKKLDNDSGIAVRLRDVTKHALVVQQLNGSLFPTGQLLAVGIYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KJY6</accession>
    <name>A0A836KJY6_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_04271</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062195.1">
        <property type="nucleotide sequence ID" value="XM_067206258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KJY6"/>
    <dbReference type="GeneID" id="92360192"/>
    <dbReference type="KEGG" id="loi:92360192"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="674"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="753"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="828"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="880"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="912"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="936"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1141"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="608"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1011"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1190"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1190"/>
            <end position="1209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5475687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1274" mass="137260" checksum="3C705317C45A6869" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KK15</accession>
    <name>A0A836KK15_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Guanine deaminase</fullName>
            <shortName evidence="7">Guanase</shortName>
            <ecNumber evidence="3 7">3.5.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Guanine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_03533</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>guanine + H2O + H(+) = xanthine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:14665"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Purine metabolism; guanine degradation; xanthine from guanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.3" evidence="3 7"/>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061468.1">
        <property type="nucleotide sequence ID" value="XM_067205531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KK15"/>
    <dbReference type="SMR" id="A0A836KK15"/>
    <dbReference type="GeneID" id="92359465"/>
    <dbReference type="KEGG" id="loi:92359465"/>
    <dbReference type="UniPathway" id="UPA00603">
        <property type="reaction ID" value="UER00660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008892">
        <property type="term" value="F:guanine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006147">
        <property type="term" value="P:guanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000070">
        <property type="entry name" value="Guanine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014311">
        <property type="entry name" value="Guanine_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051607">
        <property type="entry name" value="Metallo-dep_hydrolases"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02967">
        <property type="entry name" value="guan_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271:SF6">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="8">
        <location>
            <begin position="68"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5473465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="454" mass="49723" checksum="D1EE09A27BC067E5" modified="2021-09-29" version="1">MPVQAFLGTVFETPERRTLNIVQDALVLVRDGTIEHVINPATDAEAYASALEAASAAGHLTRLKKGQYLIPGLIDLHVHAPQWPQLGMALDRNLEVWLQEYTFPLEARYKDLEFAEKSYNSLVSTLLANGTTTVAYFASIHLESSLLLARICLAKGQRAVVGRVAMDKADQCPEYYRDASPQESVAQSEAFVEQVRALEGNADGLVLPAVIPRFVPSCTDETLRGLGQLAKKHRCHVQTHCSESDWEHNYVIQRHGKHDAMSLDDFGLMTRRTILAHSNYVSTEDMQLVKKRGAAVAHCPLSNFYFSGAVFPLQKALDIGVHVGMGTDISGGPSASLFDACRYALVAGRALESGTDPCLSATERSQRRGARVSSVEAFFVATTNGGISLDLKIGRIAPGYKFDALVIDTTLPNSSLMVFEGIDTLEDIFQKIVYSVAPHNIVQTYVNGRLVSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KKR2</accession>
    <name>A0A836KKR2_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5477921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062828.1">
        <property type="nucleotide sequence ID" value="XM_067207260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KKR2"/>
    <dbReference type="GeneID" id="92361194"/>
    <dbReference type="KEGG" id="loi:92361194"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5477921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="319" mass="34712" checksum="5EEF467BC700FF77" modified="2021-09-29" version="1">MKPYIWPSADDAPPPSARRTFPRQFQANHGTLNLFAPAATESPQRDTSTFSTSASITGQRGILHKHNHNKESTDTREFPVNGLRRVVPPRRSETSRGMRHVRDAVGAQQQVQVVNITDAYKDPAQMGPRRTGVKCVPQKSESSEVSAALTFAGSPQQLSARVLAAPVGKPSCPTPYTTDYSAQERFAQAVRDHAQQRARGVAEFYVQLVRDTVGGVTSSTPKPDIVPWSLDQEPARRVLTLERCRDQLVALTAIPVALRDLAVLLWGTDGDEAPASLATVSDADMGAPQPLGGRPVHFRDFAAAFGQNSSDVRLARMKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KL48</accession>
    <name>A0A836KL48_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_03778</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061711.1">
        <property type="nucleotide sequence ID" value="XM_067205774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KL48"/>
    <dbReference type="GeneID" id="92359708"/>
    <dbReference type="KEGG" id="loi:92359708"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5474605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="330" mass="36028" checksum="267419E60FE38297" modified="2021-09-29" version="1">MCSSAAVEGLPITLSLTLRRIDSEGEIPLPSLSPFSPPLCIYAQREDGEGVDAVQLAISGSSLLKVTVDLAASPGRLPQLSAADATAAEHVWVDQSWSVGSRFRFSIHLRARARAKWPVPRSPQWSEGSGGRLIRMPCGRPGDDDGGADVLSVQEGYTVRYTSASQNPARLGQPSSLYDRFALRSQLRGPVYINPALFPIVRILCESELYTEAIPTATAVLRNMTVQVSVERCRESRSGKPIRRAPRDRTTKENVVVLDRVPASSSHLHEESKALLEPYQAICLAFNGHVRQPSKKSAIAYDVAYAKRLVVEGYTFEVLVTGARMKGETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KL99</accession>
    <name>A0A836KL99_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_04389</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062583.1">
        <property type="nucleotide sequence ID" value="XM_067206374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KL99"/>
    <dbReference type="SMR" id="A0A836KL99"/>
    <dbReference type="GeneID" id="92360308"/>
    <dbReference type="KEGG" id="loi:92360308"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5477172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="133" mass="14894" checksum="FE898DB94F70800A" modified="2021-09-29" version="1">MHSVAKRREPAIVVAVTPASPVRPCVDLAIDIPDEPMATEEELRAWSDFDRSRPTTPSPSSGQQAWRLPKRYQGVFKERYILMILALTVLLFIASTCQMDTRTELEEIKRMHGFGESAKPIAGRTGDPHAKGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KLA7</accession>
    <name>A0A836KLA7_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_03962</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061891.1">
        <property type="nucleotide sequence ID" value="XM_067205954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KLA7"/>
    <dbReference type="SMR" id="A0A836KLA7"/>
    <dbReference type="GeneID" id="92359888"/>
    <dbReference type="KEGG" id="loi:92359888"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010564">
        <property type="term" value="P:regulation of cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039893">
        <property type="entry name" value="CEP120-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21574">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 120 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21574:SF0">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 120 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="347"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="389"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="36"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="394"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5474785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="582" mass="65363" checksum="E431AED2ED88BA33" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KLD2</accession>
    <name>A0A836KLD2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-ketoglutarate-dependent dioxygenase AlkB-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_04039</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061966.1">
        <property type="nucleotide sequence ID" value="XM_067206029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KLD2"/>
    <dbReference type="SMR" id="A0A836KLD2"/>
    <dbReference type="GeneID" id="92359963"/>
    <dbReference type="KEGG" id="loi:92359963"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032870">
        <property type="entry name" value="ALKBH7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21052:SF0">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21052">
        <property type="entry name" value="SPERMATOGENESIS ASSOCIATED 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5474860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="32174" checksum="16D086177A1968A0" modified="2021-09-29" version="1">MRAATRRLLQVPPATAAVTAPKSLLSMRGAPSFVIPPAEEAIGKGVKVTPPNWVPVYVLPEVITEQEEQALLGFSEPWFERLSYNDGHADGLIHHYKEFYRSFAAITQAAETGNDAGLNMPRANLEVDLPLISGALARVHALAQTYLPRIPIDDRVHFLRLAGSGFIRAHVDESRNSTGIVAGLCLNAGRVMTLTHPQYPGERIELMLAPRCFYIMIGRARYDWEHSVDWVGDDDEHICRIRKSLAVEGTPICFDGAETPYRRFDRTAIIFRGVSPMALLASRMRQREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KMH0</accession>
    <name>A0A836KMH0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytosol aminopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_04725</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000023">
        <property type="protein sequence ID" value="KAG5478492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063153.1">
        <property type="nucleotide sequence ID" value="XM_067206706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KMH0"/>
    <dbReference type="SMR" id="A0A836KMH0"/>
    <dbReference type="GeneID" id="92360640"/>
    <dbReference type="KEGG" id="loi:92360640"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00433">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000124">
        <property type="entry name" value="Cytosolic leucyl aminopeptidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963:SF23">
        <property type="entry name" value="CYTOSOL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="LEUCINE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00631">
        <property type="entry name" value="CYTOSOL_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytosol aminopeptidase" evidence="6">
        <location>
            <begin position="413"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5478492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="573" mass="61098" checksum="A3C01928A96A87AC" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KMV7</accession>
    <name>A0A836KMV7_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060725.1">
        <property type="nucleotide sequence ID" value="XM_067205173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KMV7"/>
    <dbReference type="SMR" id="A0A836KMV7"/>
    <dbReference type="GeneID" id="92359107"/>
    <dbReference type="KEGG" id="loi:92359107"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030254">
        <property type="term" value="P:protein secretion by the type III secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16364">
        <property type="entry name" value="T3SC_I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010261">
        <property type="entry name" value="Tir_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05932">
        <property type="entry name" value="CesT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69635">
        <property type="entry name" value="Type III secretory system chaperone-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="120"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5471608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="313" mass="34880" checksum="FB636112EE674C66" modified="2021-09-29" version="1">MDEKQAFFVEGTDGRKFKMVIRGDLGKLSVAKIRRYLKSYGVPESHDLLAGNLVLEDDLLGEQFGLENDCVLRVRDPATTQRLESVTVPPAPPPQQQQRLSYVPEEAWREPRSSMGANDTREIERKMERLQQQLEAAEARNVDLENQLAAVAKSSAACPPRDGVAGVRERSPSSDMDGLQMAKESLRILAQRLCVSLQFDKNLTCVVGTDADFSILLTYDPATERLYVYSSLLTELPDDPPLRIKLYEVLLEGSLLGREVCGGGVGLSTQNNVVVLTTSLPVRYCSPEALCDVMPPFVETLVRWRNLVDELIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KPD5</accession>
    <name>A0A836KPD5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 15">E3 ubiquitin-protein ligase listerin</fullName>
            <ecNumber evidence="5 15">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">RING-type E3 ubiquitin transferase listerin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">LSCM4_05312</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="15">E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the ribosome quality control complex (RQC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the LTN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5 15"/>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5477920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062827.1">
        <property type="nucleotide sequence ID" value="XM_067207259.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92361193"/>
    <dbReference type="KEGG" id="loi:92361193"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16491">
        <property type="entry name" value="RING-CH-C4HC3_LTN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039795">
        <property type="entry name" value="LTN1/Rkr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054476">
        <property type="entry name" value="Ltn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054478">
        <property type="entry name" value="LTN1_UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039804">
        <property type="entry name" value="RING-CH-C4HC3_LTN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12389:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE LISTERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12389">
        <property type="entry name" value="ZINC FINGER PROTEIN 294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22958">
        <property type="entry name" value="Ltn1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23009">
        <property type="entry name" value="UBC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 14 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="17">
        <location>
            <begin position="1740"/>
            <end position="1788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="724"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="733"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5477920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1794" mass="194025" checksum="12B7F09ACD3ABFFA" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Leishmania orientalis</name>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG5473543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </evidence>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KPP9</accession>
    <name>A0A836KPP9_9TRYP</name>
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        <recommendedName>
            <fullName evidence="11">Nucleoside transporter 1</fullName>
        </recommendedName>
    </protein>
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        <name evidence="9" type="ORF">LSCM4_07294</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Trypanosomatida</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000015">
        <property type="protein sequence ID" value="KAG5483079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034764">
        <property type="entry name" value="ENT1/ENT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002259">
        <property type="entry name" value="Eqnu_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00939">
        <property type="entry name" value="2a57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332:SF10">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01733">
        <property type="entry name" value="Nucleoside_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
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            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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    </feature>
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            <end position="130"/>
        </location>
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        </location>
    </feature>
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    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="500" mass="55175" checksum="60ED5BC8742857D3" modified="2021-09-29" version="1">MEAELVYQEPVEQRQMRKWYHITASEFYVYVVAFMCGVSMMMPINAVFSAPAYIMTYYRYSMQDPDAVPLHTNFWNNVMTYYNLIGIVTSLIMEPLTLLRWFRLIPIKVRLFGGLTILIVEIAVLMVVPARGTSEGGAVATLCLASFIGGFGKSIFESTTYGMFGAFPSSFTSIMMGGVGMSGVLTSLLQIIVKSALPDTYDGVKKQSKIYYGLDVGIQALTFIALLLLRFNNFAKNHFGDLGAVKSKVDAGGLATEGCRHPDEQSAEDQKGHSSSAMEGPAMGEVQLTAKAEDPAAERDDLDDCQDAVGKSVWPSEGESPTSNEILVATSVFSTLRHVKWMFVACAFDFLITLFLFPGIAVGMFPNSKWFATIAVFIFNVFDVLGRFSSSLKFMWPRSYEQRWIIVAASFARVIFVPLLLLHSYHYIPSEAYGYVMEIIFGFSNGYVGSMALVLGPRSKGIDNDGKRFVAGTLMGISILVGGTIGTVLSIMTQTLRERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KS95</accession>
    <name>A0A836KS95_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1935 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_04910</name>
        <name evidence="3" type="ORF">LSCM4_04911</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000014">
        <property type="protein sequence ID" value="KAG5483757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFHLR010000014">
        <property type="protein sequence ID" value="KAG5483758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064696.1">
        <property type="nucleotide sequence ID" value="XM_067206887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KS95"/>
    <dbReference type="SMR" id="A0A836KS95"/>
    <dbReference type="GeneID" id="92360821"/>
    <dbReference type="KEGG" id="loi:92360821"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000033">
        <property type="entry name" value="Calpain-like cysteine peptidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Golgi alpha-mannosidase II"/>
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    </dbReference>
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        <property type="entry name" value="DUF1935"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036310">
        <property type="entry name" value="Smp-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47047:SF8">
        <property type="entry name" value="CYSTEINE PEPTIDASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47047">
        <property type="entry name" value="PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09149">
        <property type="entry name" value="DUF1935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101601">
        <property type="entry name" value="Smp-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1935" evidence="1">
        <location>
            <begin position="6"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5483757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5483758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="115" mass="13025" checksum="077AC30532A8AB18" modified="2021-09-29" version="1">MSEIKFENGSPSYCGNTVLKCFKDNGNGLLFRIVNEDEHKWAFYNDTTNYRMLVKVAFGKDSKIQAIGNTSMHKDEESGEFKCELEIAPLMTEMFIEGEPNGFKISFEANPIPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KT71</accession>
    <name>A0A836KT71_9TRYP</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_06942</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000017">
        <property type="protein sequence ID" value="KAG5481865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064225.1">
        <property type="nucleotide sequence ID" value="XM_067208851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KT71"/>
    <dbReference type="GeneID" id="92362785"/>
    <dbReference type="KEGG" id="loi:92362785"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5481865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="61" mass="6380" checksum="B3DFB0F6BFB26D3B" modified="2021-09-29" version="1">MAEVLQDALLSGAQAALLCKSALDDAGYRSSRATLGKERQIVSAHNVDLRKAASATVPSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KTL1</accession>
    <name>A0A836KTL1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial ornithine transporter 1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_05553</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000016">
        <property type="protein sequence ID" value="KAG5482300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064306.1">
        <property type="nucleotide sequence ID" value="XM_067207492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KTL1"/>
    <dbReference type="SMR" id="A0A836KTL1"/>
    <dbReference type="GeneID" id="92361426"/>
    <dbReference type="KEGG" id="loi:92361426"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF12">
        <property type="entry name" value="MITOCHONDRIAL ORNITHINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="2"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="157"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="262"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="116"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5482300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="383" mass="42078" checksum="5CECDA9393BE3494" modified="2021-09-29" version="1">MADAIIHLTAGTVAGMTGVLLDYPLDTMKTRMQVSRCATAPSRYHLTSTAAATSISAPVPAKYWQCASQLYQRGGIRSFYRGLSVPLAAQGAEAAVVFSVYNVSLQHFLRKQQLRRQEQELRELSGPSGDGRPRARRHQHHHSSSEQSQPQPRAPVWSSPAHWKASACAGLAVSLILTPVEMLKCNMQMESARPPWMRHHTTVRGLARHLVATHGVRGLYTGVTGTVTRAVLGNMAYFVSYEQCREWLSQWLARPLRDGEAAPVWHSMLAGGISGCCYWSIAYPADVAKTKMQVCPQARQKGFTMTLANLYRSGGVGALYRGWGVTVVRAFLSSGIVFTTHEHCSSIFKNLSSVYSVLAQDSVVASTSSAALDRREELISHQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KUC7</accession>
    <name>A0A836KUC7_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_04756</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000023">
        <property type="protein sequence ID" value="KAG5478523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063184.1">
        <property type="nucleotide sequence ID" value="XM_067206737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KUC7"/>
    <dbReference type="GeneID" id="92360671"/>
    <dbReference type="KEGG" id="loi:92360671"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5478523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="102" mass="12012" checksum="7D5A53CC30BC69F7" modified="2021-09-29" version="1">MDGEVRVALLALWRDAAWMWRGQQCYWRLWSIRLEGVGLRLGYAQVSGLVEVDAYQRLSEVELFDLTNSTLVVCECEIRGHSFIDEYTVFAELMMREVERYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KUU6</accession>
    <name>A0A836KUU6_9TRYP</name>
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        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_08223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
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            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000003">
        <property type="protein sequence ID" value="KAG5487999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066126.1">
        <property type="nucleotide sequence ID" value="XM_067210093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KUU6"/>
    <dbReference type="GeneID" id="92364027"/>
    <dbReference type="KEGG" id="loi:92364027"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5487999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="38653" checksum="EC6256B0A94E01E9" modified="2021-09-29" version="1">MAVAWVAKRTHLCRGGPRWVASVCAGERGRSHAALLRRLSCGGSAIAKQPGDVCVWAELSQRCHSTVKGSRITGASRGAASPFESLAASQQSTVEDLFTSRFDTGTAAHRYGISASAALPLASRIAAPDSLFSERFPSLAAQTTAKVHGSTAPCGGTKAKAAPWGGLWQCLTSRNHPAAVSINSTVSSTPHPASTANDMKPPVPLPPSAGFSLQRPPVAGETVGLSSSGLPQPPPEVQRYWNSYRLWASLQPHIQQEQQAVLHLRAQAHAAKVAQQESLRQHLYRTMYWTVFVVCPLLGLLFLWLTIDAAAYGAELEVVPFVKYDEALRDFSEAEGHYRRLRNAKGNNGTSKKKNVRID</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KUY3</accession>
    <name>A0A836KUY3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_04908</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000014">
        <property type="protein sequence ID" value="KAG5483755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064694.1">
        <property type="nucleotide sequence ID" value="XM_067206885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KUY3"/>
    <dbReference type="GeneID" id="92360819"/>
    <dbReference type="KEGG" id="loi:92360819"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF131">
        <property type="entry name" value="KINASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="354"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="522"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="704"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="846"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="129"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="205"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="560"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5483755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="887" mass="92330" checksum="5E314612AAFFEE67" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KVN5</accession>
    <name>A0A836KVN5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C-CAP/cofactor C-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_05821</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063524.1">
        <property type="nucleotide sequence ID" value="XM_067207751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KVN5"/>
    <dbReference type="SMR" id="A0A836KVN5"/>
    <dbReference type="GeneID" id="92361685"/>
    <dbReference type="KEGG" id="loi:92361685"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008179">
        <property type="term" value="F:adenylate cyclase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019933">
        <property type="term" value="P:cAMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.330">
        <property type="entry name" value="Adenylate cyclase-associated CAP, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001837">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013912">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036223">
        <property type="entry name" value="CAP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053950">
        <property type="entry name" value="CAP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036222">
        <property type="entry name" value="CAP_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10652">
        <property type="entry name" value="ADENYLYL CYCLASE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Bates M.D."/>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15844">
        <property type="entry name" value="SNARE_syntaxin5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.70:FF:000034">
        <property type="entry name" value="Syntaxin 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF3">
        <property type="entry name" value="SYNTAXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="9">
        <location>
            <begin position="214"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5469977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="307" mass="35312" checksum="30019A6158F5F740" modified="2021-09-29" version="1">MVVERDRSSELYDLFSRQRQSQQPPTSRAVVCTGLHSSSDVQTFNRFAKEFSNNIATVSEYIIRLAQLANRQSVFDDQTAEVSELTQMVKSSLQRLHKDAETLEELKRRAVESQKGTFLPKGDARGMFGGVSNHLRTSERHSDTVVETLRSRLARTGQQFRTTLQQQSRSLKDKANRRHMFTTADRPQTFESALFQDQEQHQQQQLLLSGTRNTHYYQQRADAVLEIEAAVQEVGELFNDFTRLVQEQEEVVLRIDTDVDNAVRHVNAGSNELMRYLTNLSSNRGLILKVFAMLFFFLLLFGVFVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FZB9</accession>
    <name>A0A836FZB9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="30">Dynein heavy chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">LSCM4_00096</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="29" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
            <location evidence="1">Flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dynein heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="28">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058287.1">
        <property type="nucleotide sequence ID" value="XM_067202186.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836FZB9"/>
    <dbReference type="GeneID" id="92356120"/>
    <dbReference type="KEGG" id="loi:92356120"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036156">
        <property type="term" value="C:inner dynein arm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060294">
        <property type="term" value="P:cilium movement involved in cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036159">
        <property type="term" value="P:inner dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1220:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000004">
        <property type="entry name" value="Dynein axonemal heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002141">
        <property type="entry name" value="Dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000001">
        <property type="entry name" value="dynein heavy chain 17, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2620:FF:000002">
        <property type="entry name" value="Dynein heavy chain 2, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1120:FF:000001">
        <property type="entry name" value="dynein heavy chain 2, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000001">
        <property type="entry name" value="dynein heavy chain 2, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000044">
        <property type="entry name" value="Dynein heavy chain 5, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000001">
        <property type="entry name" value="dynein heavy chain 7, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.280:FF:000001">
        <property type="entry name" value="dynein heavy chain 7, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.20:FF:000001">
        <property type="entry name" value="dynein heavy chain 7, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.30:FF:000009">
        <property type="entry name" value="Dynein heavy chain 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000049">
        <property type="entry name" value="Dynein, axonemal, heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000362">
        <property type="entry name" value="Dynein, axonemal, heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002213">
        <property type="entry name" value="Putative dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054354">
        <property type="entry name" value="DYNC2H1-like_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878:SF73">
        <property type="entry name" value="DYNEIN AXONEMAL HEAVY CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22597">
        <property type="entry name" value="DYN_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
    <keyword evidence="12" id="KW-0969">Cilium</keyword>
    <keyword evidence="11 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0243">Dynein</keyword>
    <keyword evidence="9" id="KW-0282">Flagellum</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="13" id="KW-0505">Motor protein</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
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        <location>
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            <end position="1410"/>
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            <begin position="1540"/>
            <end position="1866"/>
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        <location>
            <begin position="2034"/>
            <end position="2163"/>
        </location>
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        <location>
            <begin position="2373"/>
            <end position="2456"/>
        </location>
    </feature>
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        <location>
            <begin position="2552"/>
            <end position="2813"/>
        </location>
    </feature>
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        <location>
            <begin position="2827"/>
            <end position="3171"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain ATP-binding dynein motor region" evidence="23">
        <location>
            <begin position="3201"/>
            <end position="3421"/>
        </location>
    </feature>
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            <begin position="3667"/>
            <end position="3779"/>
        </location>
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        <location>
            <begin position="3812"/>
            <end position="3950"/>
        </location>
    </feature>
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        <location>
            <begin position="3957"/>
            <end position="4268"/>
        </location>
    </feature>
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        <location>
            <begin position="15"/>
            <end position="69"/>
        </location>
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        <location>
            <begin position="2525"/>
            <end position="2552"/>
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            <begin position="2863"/>
            <end position="2926"/>
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            <begin position="3057"/>
            <end position="3112"/>
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            <begin position="17"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
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        <source>
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            <dbReference type="Pfam" id="PF22597"/>
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            <dbReference type="EMBL" id="KAG5464656.1"/>
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            <dbReference type="Proteomes" id="UP000674143"/>
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            <dbReference type="Google" id="ProtNLM"/>
        </source>
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    <sequence length="4272" mass="484890" checksum="E6A01EB709EAFB8F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G0R0</accession>
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            <fullName evidence="5">Translocon-associated protein subunit beta</fullName>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836G454_9TRYP</name>
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        <recommendedName>
            <fullName evidence="9">CEP76 C2 domain-containing protein</fullName>
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        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
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    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG5474792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067205961.1"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A836G454"/>
    <dbReference type="GeneID" id="92359895"/>
    <dbReference type="KEGG" id="loi:92359895"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052299">
        <property type="entry name" value="CEP76"/>
    </dbReference>
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        <property type="entry name" value="CEP76-C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056288">
        <property type="entry name" value="CEP76_C"/>
    </dbReference>
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        <property type="entry name" value="CEP76_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056290">
        <property type="entry name" value="CEPT76/DRC7_peptidase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46436">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 76 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46436:SF1">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 76 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15627">
        <property type="entry name" value="CEP76-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24652">
        <property type="entry name" value="CEP76_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24654">
        <property type="entry name" value="CEP76_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24656">
        <property type="entry name" value="CEPT76_peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CEP76 N-terminal" evidence="5">
        <location>
            <begin position="18"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="CEP76 C2" evidence="3">
        <location>
            <begin position="95"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="CEP76/DRC7 peptidase-like" evidence="6">
        <location>
            <begin position="345"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Centrosomal protein of 76 kDa C-terminal" evidence="4">
        <location>
            <begin position="485"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5474792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="627" mass="69239" checksum="2C02B30A7F64DEDF" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G7R1</accession>
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            <fullName evidence="4">Arrestin-like N-terminal domain-containing protein</fullName>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="478" mass="52448" checksum="CEDA7AEA6381608D" modified="2021-09-29" version="1">MDCSLAVSAAPHRLWYIAGDVVKVRLSLTCVPKVEPTQRKEVVPLKRVSKHNYFSIDASEEQPQEMDVRVAPLEVELAGVVEVDPSVMKTISWSAAVSENETPGSSRPDASRSKMVYTLYSTGKKMLREDVHLKRYECTAHEFVFRLPEGCPPTFKGRGADYRHDITIYATWYTVRTNSAARATIPHIRKVRVPLTVFNSVATLAQLPLMSLFPLPPDSALVAEGFHFQAAPLASVPTPLTAAPLMDVMLPQEAQLRTSLTVRHDAKATIQTNLASQRQPLSLMLPCKDINVLQVRLDSSCVPIGDFLQGSFTVLDTSRGPSGTIADRRTQSSEDADTPVPVSVSVSLELLECVTPEWALTTDDASVTVTRQQGMENFICTHLRVVDRAQFCVLDTPCMPFEFSLPVGLVPASSITDITSFLWQLRVTMMAVPRKALAQASSKGVDRLGPLLEPVAAVFPLIVTPPSVPSKTRQGTVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G9Q6</accession>
    <name>A0A836G9Q6_9TRYP</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02627</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060206.1">
        <property type="nucleotide sequence ID" value="XM_067204654.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92358588"/>
    <dbReference type="KEGG" id="loi:92358588"/>
    <dbReference type="Proteomes" id="UP000674143">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR35615:SF7">
        <property type="entry name" value="PRESENT IN THE OUTER MITOCHONDRIAL MEMBRANE PROTEOME 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35615">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <end position="100"/>
        </location>
    </feature>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="363"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="405"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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        </location>
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        <location>
            <begin position="1189"/>
            <end position="1201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5469229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1556" mass="166292" checksum="146228BB3EE11554" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G9V8</accession>
    <name>A0A836G9V8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amastin-like surface protein-like protein</fullName>
        </recommendedName>
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        <name evidence="2" type="ORF">LSCM4_05415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
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            <taxon>Trypanosomatida</taxon>
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            <taxon>Leishmania</taxon>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5478017.1"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="167"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
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            <dbReference type="EMBL" id="KAG5478017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="20318" checksum="A38BBD2B42856ED0" modified="2021-09-29" version="1">MPACLAYYTGAMTFTLIHFFAWAFAFVATPTAQFQTPGYGCYTMWGYRKFCGNVSYDLTGDAAFGCPRRTSTMRCGAAFGVMASACGFAALVFAILLNTQIQLPVVISFVLAAVCIPFTMISWACVASVYNMTMCGDRFGSKYPYTAGFALMVASWGLEIIAVVVLACTSWTRPPREEEDHIDAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
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    <gene>
        <name evidence="3" type="ORF">LSCM4_00451</name>
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    <organism evidence="3 4">
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    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465002.1"/>
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        <property type="nucleotide sequence ID" value="XM_067202532.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051397">
        <property type="entry name" value="Zn-ADH-like_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677:SF3">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="17"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5465002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="340" mass="36183" checksum="1CA3B2AEBFBC32DF" modified="2021-09-29" version="1">MASPKNFKKLQVTSLSKDFRNATSVVEAQLPEEVPEGKVRVYVKYAGVNASDLNFTNGSYFTSARPPYDCGFEAAGTVVKIGAGVTTVKEGDHVVIMQYGCFAQFLDAPAEACVLVPELKPECVVLAVSALTAAVALGEVGRVKKGDVALVTAAAGGTGQVAVQLLKHVYGCTVIGTCSSEEKAEFLKSIGCDYIINYKRESLDSRLHELCPKGVDVVYECVGGHLFNDAVRNLAVHGRLVVIGSISSYKGGETVPFSSTSGSPLATVLLLKSASLSGFFLPHFHKAIPKYLTDLLQYLKSGQVKLFVDKKVFQGLSSVADAVDHLYSGTSFGKVVVEIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GG69</accession>
    <name>A0A836GG69_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">40S ribosomal protein S18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_00094</name>
        <name evidence="8" type="ORF">LSCM4_00095</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">LSCM4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058285.1">
        <property type="nucleotide sequence ID" value="XM_067202184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GG69"/>
    <dbReference type="SMR" id="A0A836GG69"/>
    <dbReference type="GeneID" id="92356118"/>
    <dbReference type="KEGG" id="loi:92356118"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.50:FF:000002">
        <property type="entry name" value="40S ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.910.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="entry name" value="30s ribosomal protein s13, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_uS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="Rbsml_uS13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_uS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_uS13_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003140">
        <property type="entry name" value="PRK04053.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S13/40S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5464654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5464655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="153" mass="17380" checksum="C8D3ACE402956DED" modified="2021-09-29" version="1">MSLTLIPDHFQHIVRLLNTNVEGKRKVPFALRMVKGVGIRFAYLVCKKAGIDVERRAGTLTAEELEKVAEIIADPAKFKIPDWFLNRQRDPKTGKTEHLSSSMVDTRLRDDLERLKKMRAHRGVRHAYGLRVRGQHTCTSGRHGKTVGVSRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GGK3</accession>
    <name>A0A836GGK3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]</fullName>
            <ecNumber evidence="9">1.3.1.88</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LSCM4_03297</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">LSCM4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>5,6-dihydrouridine(16) in tRNA + NAD(+) = uridine(16) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53380"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:53382"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5,6-dihydrouridine(16) in tRNA + NADP(+) = uridine(16) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53376"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:53378"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>5,6-dihydrouridine(17) in tRNA + NAD(+) = uridine(17) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53372"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:53374"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>5,6-dihydrouridine(17) in tRNA + NADP(+) = uridine(17) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53368"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:53370"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Dus family. Dus1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.88" evidence="9"/>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060861.1">
        <property type="nucleotide sequence ID" value="XM_067205309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GGK3"/>
    <dbReference type="GeneID" id="92359243"/>
    <dbReference type="KEGG" id="loi:92359243"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082">
        <property type="entry name" value="TRNA-DIHYDROURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082:SF5">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(16_17) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
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    <sequence length="652" mass="71081" checksum="AA34D39D58838067" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GIS9</accession>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512:SF5">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
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            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="1528" mass="164804" checksum="456B353072B3661F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GJ27</accession>
    <name>A0A836GJ27_9TRYP</name>
    <protein>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061750.1">
        <property type="nucleotide sequence ID" value="XM_067205813.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="92359747"/>
    <dbReference type="KEGG" id="loi:92359747"/>
    <dbReference type="Proteomes" id="UP000674143">
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5474644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="194" mass="21081" checksum="2255608E1EC07EBC" modified="2021-09-29" version="1">MSGVMRYSQSACAAPQGKSDTFVTSLDVFSRASYIDPYRTHVGVDVLPATATLTQAQLEQAPMDAGSPSACKSEGGAENCVAFDESAVSKLKRFSSLSAFTAANSVIDYLQENLGGVVLPDDGVGRDVLLQRRRSFFDSLFTIEEDLRTAFPCRFSTSDVDNLFRSTSEEDVSSTESYRRRLAALQKLRSTLGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GJB1</accession>
    <name>A0A836GJB1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">DNA topoisomerase</fullName>
            <ecNumber evidence="4 12">5.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">LSCM4_00344</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 19 20">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="4 12"/>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058529.1">
        <property type="nucleotide sequence ID" value="XM_067202428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GJB1"/>
    <dbReference type="SMR" id="A0A836GJB1"/>
    <dbReference type="GeneID" id="92356362"/>
    <dbReference type="KEGG" id="loi:92356362"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031422">
        <property type="term" value="C:RecQ family helicase-topoisomerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03362">
        <property type="entry name" value="TOPRIM_TopoIA_TopoIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.290.10:FF:000003">
        <property type="entry name" value="DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.140:FF:000003">
        <property type="entry name" value="DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="entry name" value="Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="entry name" value="Topoisomerase I, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="entry name" value="Topoisomerase I, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034144">
        <property type="entry name" value="TOPRIM_TopoIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010666">
        <property type="entry name" value="Znf_GRF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390:SF21">
        <property type="entry name" value="DNA TOPOISOMERASE 3-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PROKARYOTIC DNA TOPOISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06839">
        <property type="entry name" value="Zn_ribbon_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="Prokaryotic type I DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPO_IA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52039">
        <property type="entry name" value="TOPO_IA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51999">
        <property type="entry name" value="ZF_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0799">Topoisomerase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="14">
        <location>
            <begin position="3"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IA-type catalytic" evidence="16">
        <location>
            <begin position="161"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="GRF-type" evidence="15">
        <location>
            <begin position="908"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="872"/>
            <end position="894"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS52039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG5464898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="944" mass="103354" checksum="A63C6A47E0AF6A3B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GK93</accession>
    <name>A0A836GK93_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060209.1">
        <property type="nucleotide sequence ID" value="XM_067204657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GK93"/>
    <dbReference type="GeneID" id="92358591"/>
    <dbReference type="KEGG" id="loi:92358591"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35615:SF6">
        <property type="entry name" value="KINESIN MOTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35615">
        <property type="entry name" value="PRESENT IN THE OUTER MITOCHONDRIAL MEMBRANE PROTEOME 22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="568"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="943"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="447"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5469232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1121" mass="120814" checksum="C06F57CCA6AFB885" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GKL9</accession>
    <name>A0A836GKL9_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_04081</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062007.1">
        <property type="nucleotide sequence ID" value="XM_067206070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GKL9"/>
    <dbReference type="SMR" id="A0A836GKL9"/>
    <dbReference type="GeneID" id="92360004"/>
    <dbReference type="KEGG" id="loi:92360004"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032277008" evidence="2">
        <location>
            <begin position="19"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5475499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="123" mass="14287" checksum="908E7EAD5383D3B1" modified="2021-09-29" version="1">MMPFLLVSSVISCSSASACEPYCSESRLSHFRFRTSSQIRPTTTQRLHHVTILMPRAHQRVELEGSIFSRVVEQGWVAFLILGALMVALRLYNVKQRRDQRKLLREGLMAEMRYCSKANRKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GM50</accession>
    <name>A0A836GM50_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Complex I-ESSS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">NADH-ubiquinone oxidoreductase ESSS subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">LSCM4_01164</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Complex I is composed of 45 different subunits. Interacts with BCAP31.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB11 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5468075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059877.1">
        <property type="nucleotide sequence ID" value="XM_067203227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GM50"/>
    <dbReference type="SMR" id="A0A836GM50"/>
    <dbReference type="GeneID" id="92357161"/>
    <dbReference type="KEGG" id="loi:92357161"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019329">
        <property type="entry name" value="NADH_UbQ_OxRdtase_ESSS_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10183">
        <property type="entry name" value="ESSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG5468075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="112" mass="13667" checksum="7E9C613064B13B64" modified="2021-09-29" version="1">MAGWNQKMAKMAFRRSKFRRLAWGDGDPYPYTPRATFRYQWDDWPMWEKMRHLSVGVLGIEFAVWAYYSKLNSRMDWAREEALRRMRLRREAQELMILEGETFSSDIQPDRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GMF3</accession>
    <name>A0A836GMF3_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059423.1">
        <property type="nucleotide sequence ID" value="XM_067203732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GMF3"/>
    <dbReference type="GeneID" id="92357666"/>
    <dbReference type="KEGG" id="loi:92357666"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5466533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="465" mass="52398" checksum="15CD236F8415C2CE" modified="2021-09-29" version="1">MRRIGARVWGCCFGAASTAARRTFASVPGEISEAERRHLDQELPPRELLREMRSTDTPPGEEEEDAIKVPGDSFGIMRNRVAFYKPLQRHALSGRIGELMPVGTHPLACFNPGTVRRMCSRYGVSVDDVVAALRDASGDINLATELLEQRLDIEVGFGSYGLVCLESYAPETFCLVSYNLPTFSSTQSDEVLDAIHELTLSAAELPLDTPRDRLVDRFVNHWTTEDNVPCGDVLRAYDITVQNILLLPFGDYGVQGFHVLMPVKKETPNIGVAAAACCMDLRTGIHNRFRFHVERVADSVSEHVLQEMLHYNQGVHLLRQPYWFRPEYSVEEFIRFKESLLQPSASTFEMRYAFLFAPQYALPHYRNIIEMEKLKIAQHKYEKHYEDFTAPGKWLTSDNAQLQTVAAGGGGSSVPGGAMHYHTNDPASIRTAMETRTGPLRRTLAQSMQAHGDRVFSRFYRNNVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GMR6</accession>
    <name>A0A836GMR6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_07629</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000012">
        <property type="protein sequence ID" value="KAG5484857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064969.1">
        <property type="nucleotide sequence ID" value="XM_067209509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GMR6"/>
    <dbReference type="SMR" id="A0A836GMR6"/>
    <dbReference type="GeneID" id="92363443"/>
    <dbReference type="KEGG" id="loi:92363443"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000148">
        <property type="entry name" value="Elongation factor 1B gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050802">
        <property type="entry name" value="EF-GSTs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986:SF1">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5484857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="365" mass="40923" checksum="CBAF9BB05B277243" modified="2021-09-29" version="1">MVVSLIGPLDSPYVQRTLLVAAYAGIQLKVVPIEAGKENETEEYRLNCHPMQRVPVMKTDEGYLFESHAMIRYLARTEVMLVSVDAAANNEKIPHPHYPIPYAMYGHSLLESTQVDSWLDFVTTHIDFYTKQFLAYEQAVGPKPSEDVKKLLCKSLDGLERRLIYLKETSRELAQQSGALSARPVMTNEELLWNEEDYMASRATRDLRLSSVYNVAGSIRQRHMEKERQERDKQLRLIKKTTDEALGEEGADDLHRASHRASASRESMMISATPRSSALMSARGSVMGNSASAVQRKDLLFLVGGSLTAADLVMAMSLHDALCCHELKPVIISNYPNSFKYYKNVLMLPVAAEVGKAIRLSVIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GPL7</accession>
    <name>A0A836GPL7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_03151</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060719.1">
        <property type="nucleotide sequence ID" value="XM_067205167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GPL7"/>
    <dbReference type="SMR" id="A0A836GPL7"/>
    <dbReference type="GeneID" id="92359101"/>
    <dbReference type="KEGG" id="loi:92359101"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052981">
        <property type="entry name" value="Ingression_C2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47052">
        <property type="entry name" value="CONSERVED SERINE PROLINE-RICH PROTEIN (AFU_ORTHOLOGUE AFUA_2G01790)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47052:SF3">
        <property type="entry name" value="INGRESSION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5471602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="338" mass="37926" checksum="68227958ED5DD822" modified="2021-09-29" version="1">MGKIEVTVCAARNLHSQQLVDLPDPFVRVGLGEKKYKTRVAKNSLNPEWNETFRFEVADEMSAQVRLEVWSKCTYSDDLMGYYNLSLGGLTKGIVKDKWYILEKSKTEAELRVRVLAVDFGATPKPEEQWMVTEDIRRDPAKRALEDGTWRPGQKTAPPPSGPPQLQQQQMYAVPAPAPQQLQAQQVQPQPELLGIQYVAAPPPSGPLQLQQQQMYAVPAPAPQQLQAQQVQTQPELLGIQYVAAPPQQVPYVLQPQVQYLQQSQAPYIAQQQPVIYVQQQPPQGYYQPCPPPQPLGYYPACPPPALQNGYYQQASLLSHQGYYAQPPPQGYAPQPPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GQ55</accession>
    <name>A0A836GQ55_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5477959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062866.1">
        <property type="nucleotide sequence ID" value="XM_067207298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GQ55"/>
    <dbReference type="GeneID" id="92361232"/>
    <dbReference type="KEGG" id="loi:92361232"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5477959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="159" mass="17594" checksum="10FC651730C90B2B" modified="2021-09-29" version="1">MLRLSRVALFIVPSRSSPELTHLRRRGTKPTVTTSGELYAFVIEYDHRGAIPRFCRGPYRGDFFSTAAFSGSLAAGILTAGGVALFTLTFGYNIGKPVVDAHRELFWKSADAARGNRSLESLERAAAKKNGRDDVTPVEEFDDHIELEQDEGQLHSHTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GQC8</accession>
    <name>A0A836GQC8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phospholipase/carboxylesterase/thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_05478</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5478079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062986.1">
        <property type="nucleotide sequence ID" value="XM_067207418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GQC8"/>
    <dbReference type="SMR" id="A0A836GQC8"/>
    <dbReference type="GeneID" id="92361352"/>
    <dbReference type="KEGG" id="loi:92361352"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF17">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="4">
        <location>
            <begin position="202"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5478079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="418" mass="44812" checksum="E896C8BB94350451" modified="2021-09-29" version="1">MHREPGLISMNNVGQSPAALLKAVAVLLVAVAVALVAHRMIEGTKRAHSSDVAWRRQADEAMATTPVAPSTAERPACMSRTAFPASHARPSSSPPSSSVLLPFSPTPFTPRSNFYKVTYVTSNASAIPAISAATLEKSVAMAVPVEQLTSAQMMDELRTLYDITDSTDCIEHGDLQKKLQATRDSAPITHGLRYGTLLEIGNKSPTGIVTLIHGLGDSAYGWEDVGHELSRRLPHLLFLLPTAPSRRVTINGGMLMPAWYDIMDMTNNGLLSGRQDATSVRQSCDYVRSIAHVAAKKHGIAPQRVVYGGFSQGAAISLCAGLTAHIAPAGIACMSGYLAACADVLPRIIQKAVPITMFHGRQDPVVPLSAAKETREILEKNAGVSPISFLEYNMQHSTLPEEINDLAAFISRVLPTKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GQT4</accession>
    <name>A0A836GQT4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LicD/FKTN/FKRP nucleotidyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_02809</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060381.1">
        <property type="nucleotide sequence ID" value="XM_067204829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GQT4"/>
    <dbReference type="GeneID" id="92358763"/>
    <dbReference type="KEGG" id="loi:92358763"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009100">
        <property type="term" value="P:glycoprotein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007074">
        <property type="entry name" value="LicD/FKTN/FKRP_NTP_transf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052942">
        <property type="entry name" value="LPS_cholinephosphotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43404">
        <property type="entry name" value="LIPOPOLYSACCHARIDE CHOLINEPHOSPHOTRANSFERASE LICD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43404:SF1">
        <property type="entry name" value="MNN4P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04991">
        <property type="entry name" value="LicD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LicD/FKTN/FKRP nucleotidyltransferase" evidence="2">
        <location>
            <begin position="269"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5470115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="491" mass="53987" checksum="692BDF90E8D78243" modified="2021-09-29" version="1">MQRYSRAWKRAASAAFRPHLHREDCRICGAAASTEKNTVHGRTAALSCTTAPDHRATPQTSLSRKPRAPGHQGVLRCLVGAPPSVFELRRTALLDWLQQFSRQERRAGTSDVETARSGESVGVLNSIDDFDAAYEAYLRCEEATVQEALFARLVDCLDAQCDPRVIRSGASPTSTPAAVAASAAAAEGKQWGGVRIPQCLVVSRVDTAFTPIERKATAPCAEEETDPARAENDFETYVRRRFSGSEALITKQLAFQEALLAVQEVLVSQGIRFFLACGTALGARRDGCFIPYDEDIDLGILYTDIVAPVMDGDDLPMPNLSFPSTAPAGLSCAQVRLYRLLQALASTGAFVVFDVCGAVEKGLELRVLHLATRARIDINLYYPPLCATFCGVRGDASDEALVREKGAFVWAASFYEAADARRHHMYRYRHKPFATELEELPFCAKTASSCKGFLVPPERYLVENYGEDWRTSKQYSYTEGLAGEFKNIVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GR22</accession>
    <name>A0A836GR22_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial edited mRNA stability factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060501.1">
        <property type="nucleotide sequence ID" value="XM_067204949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GR22"/>
    <dbReference type="SMR" id="A0A836GR22"/>
    <dbReference type="GeneID" id="92358883"/>
    <dbReference type="KEGG" id="loi:92358883"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="434"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="460"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5470235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="480" mass="52263" checksum="D3F5C4BF9CF48E96" modified="2021-09-29" version="1">MELTGPLLYCSRMRALVAPIHAGSSSLRWAKASSSLMSGLTGVEATASSAWASTSGSRCSAAAQKVSCRWQSTGDEYGHVTDDTSGLQSELSHALAGEGNLAMDALLSQPLVKADLQTPSARIRLDKIERPPGRFDLLTNSLVYRWQTTAALARKVTGPMREWASELKYRTGVHLEVEPTNPARLDVSEAEGGYASADDVELTVYLFGSERGIFNCRQLMETALDQDPAYVRLAVFRRKPGTGGSADGAAAPRPDEDVEWLLLRRINRDLRPPDIPPISLKTPGKWTLLYEHYKEAAIRTLWEETGITVEAGNVYPTAVLCQDNPVFYWRVPVHYFLAEVPYDVEVLGPQVGLNTYMHHWDSSLLRQSPDPIDRAWAQLADPETGCAWMKKPMIDELQRPLRGANYMATRYTPPPYSELNDILGLEVPAEATGESSAVEPAPSAATSAEGVQAQHDAKESAATAPSTDADTSSSSGKPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GR52</accession>
    <name>A0A836GR52_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ras-related protein Rab-21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_05799</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endomembrane system</location>
            <topology evidence="10">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063502.1">
        <property type="nucleotide sequence ID" value="XM_067207729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GR52"/>
    <dbReference type="SMR" id="A0A836GR52"/>
    <dbReference type="GeneID" id="92361663"/>
    <dbReference type="KEGG" id="loi:92361663"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032482">
        <property type="term" value="P:Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04123">
        <property type="entry name" value="Rab21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002608">
        <property type="entry name" value="Small GTP-binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041833">
        <property type="entry name" value="Rab21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="230"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5479791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="290" mass="30042" checksum="61D556E4853855DD" modified="2021-09-29" version="1">MGVSMRGLSFKVVLLGEGRVGKTSLISRYVHNTFDDREASTVQASMYSSKAVPINDASNAPGAIREVDLALWDTAGQERFHALAPMYYRNADGAIIVYDVTDADTLRKVRTWAKELYAVVGEGNIQLVLCGNKADAPPAEREVSEGEGATMAAELGAVHFFASAKTGQNVAEVFSAMATQILRSRDATGAGSGAAPGSSIGASVGGAFAGIGARTPSRSRPRRGLMVVTEDGEAVTPGRRSPNDGRVYGGITPPRAHRYGSSGANQPITLSADGSSDAAAATAKGRSGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GT01</accession>
    <name>A0A836GT01_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">propanoyl-CoA C-acyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.176</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Propanoyl-CoA C-acyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_04697</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.176" evidence="1"/>
    <dbReference type="EMBL" id="JAFHLR010000023">
        <property type="protein sequence ID" value="KAG5478464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063125.1">
        <property type="nucleotide sequence ID" value="XM_067206678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GT01"/>
    <dbReference type="SMR" id="A0A836GT01"/>
    <dbReference type="GeneID" id="92360612"/>
    <dbReference type="KEGG" id="loi:92360612"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00829">
        <property type="entry name" value="SCP-x_thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055140">
        <property type="entry name" value="Thiolase_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870:SF1">
        <property type="entry name" value="NON-SPECIFIC LIPID-TRANSFER PROTEIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22691">
        <property type="entry name" value="Thiolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="5" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="7">
        <location>
            <begin position="42"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="8">
        <location>
            <begin position="306"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5478464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="441" mass="47382" checksum="59B3C382017E7D93" modified="2021-09-29" version="1">MFRSSVTQLHAASGVYIVGGYLTPFVGKGSKLFIDKKHPDFGKKQNMTLEEILSTTVQHTVENTGLKGKEEIVDQIVVGNFLGELFSNQGHLGPAAIGSLTYGQAGAKNPLMYRPALRVEGACASGGLAIMSAVNALKAGSADITLAVGVEVQTTASARVGGDYLARAADYKRQRKLDDFTFPCLFAKRMKYIAEQHHFTMEDTARVAAKAYANGNKNPLAHMHTRKLSFEQCNGDDPSNVRFLGNETYREYLRMTDCSQVSDGGAGVVLVNEEGLRKMGLSPSDSRLVKLKSLSCAASNLYEDPEDACCMSTSRQAAQKALSMANVKPSDLSVAEVHDCFTIAELLMYEALGIAEYGHAKDLIRNGDTTLEGRIPVNTGGGLLSFGHPVGATGVKQIMEVYRQMKGQCGAYQMKKIPALGATLNMGGDDKTAVSTVLENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GTA0</accession>
    <name>A0A836GTA0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ribonuclease</fullName>
            <ecNumber evidence="12">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LSCM4_00031</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2 12">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11 12">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the RNase HII family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="12"/>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058222.1">
        <property type="nucleotide sequence ID" value="XM_067202121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GTA0"/>
    <dbReference type="GeneID" id="92356055"/>
    <dbReference type="KEGG" id="loi:92356055"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07182">
        <property type="entry name" value="RNase_HII_bacteria_HII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000193">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000194">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022898">
        <property type="entry name" value="RNase_HII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF23">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51975">
        <property type="entry name" value="RNASE_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11 12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11 12" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-2" evidence="13">
        <location>
            <begin position="178"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG5464591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="523" mass="58727" checksum="0DCF0DD689991075" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GTF1</accession>
    <name>A0A836GTF1_9TRYP</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">LSCM4_03697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067205693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GTF1"/>
    <dbReference type="GeneID" id="92359627"/>
    <dbReference type="KEGG" id="loi:92359627"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5473627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="68" mass="7558" checksum="F5811EC85CD88877" modified="2021-09-29" version="1">MKKSISLKEFSTTPTVSYMLSKDGHNVAAAADAQSRPINPPPQPLRVERARQQQQPAPDSDDAMYEME</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GUV1</accession>
    <name>A0A836GUV1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FG-GAP repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="KEGG" id="loi:92358931"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34284">
        <property type="entry name" value="FG-GAP REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34284:SF1">
        <property type="entry name" value="FG-GAP REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="674"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5470283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="726" mass="80290" checksum="EE7C6EFAE5B0EB7B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GV50</accession>
    <name>A0A836GV50_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_06970</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000017">
        <property type="protein sequence ID" value="KAG5481891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064251.1">
        <property type="nucleotide sequence ID" value="XM_067208877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GV50"/>
    <dbReference type="SMR" id="A0A836GV50"/>
    <dbReference type="GeneID" id="92362811"/>
    <dbReference type="KEGG" id="loi:92362811"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000535">
        <property type="entry name" value="MSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00635">
        <property type="entry name" value="Motile_Sperm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50202">
        <property type="entry name" value="MSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="MSP" evidence="3">
        <location>
            <begin position="42"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="335"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <begin position="23"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5481891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="432" mass="46995" checksum="D3C5FEB44C576EC5" modified="2021-09-29" version="1">MDPHHSLVSASPSEGVIESPLGAKHHSPSHQQRHRSAKTHSQIKIEPNCLVFPPPHFGRCIQNAISIYNVSKQPCVFKMRSQNPERYVAKPHVAIMAPESATRSFVTLRDMNTMGVKNLPEGTQDRFRFSVKLYDPDTVDPSLSPKDLWSLLAARGQRVDHEQDLIAYFTKRDTPVGGLVTFFPPTYIPVIPLAASKAASLSTPATASIGAQGSHSAATLTCNGDASAEAQRRKTGGGAAPKSAAFFSAAKDTAASRVFWIIVSIVTVMVLSVAVMTRRMWGVGDTAVVQVEAAAAPGRPAPELLAKQAHRVVRTVSVEPPTPHVRLMQQYGEPGAEPVQMQPHSQHRKGHQSSETEVAPPAIESPRQHYDAPPAHEEAYYHRHQEHCQGPEARVETAVAESAHQAHAEHAPRQQQEAHQHTEQAVPPAFPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GVT6</accession>
    <name>A0A836GVT6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_02138</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061211.1">
        <property type="nucleotide sequence ID" value="XM_067204174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GVT6"/>
    <dbReference type="SMR" id="A0A836GVT6"/>
    <dbReference type="GeneID" id="92358108"/>
    <dbReference type="KEGG" id="loi:92358108"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001043">
        <property type="entry name" value="RNA-binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001110">
        <property type="entry name" value="RNA-binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="4"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="95"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="173"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="265"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5472815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="503" mass="54093" checksum="2E41DC1AC2A5CC9A" modified="2021-09-29" version="1">MSLQNLFVAKLPRNINDADLLHIFADFGPSSAKIMLDASTGKSKGFGFVLFDEEEKGARAYKAMNRKMTRACGHSFTLVIYPSNHNGKIFTEESNALYIRNIPMSVGQERVERFLKTFGNLIYFAMREDHYGNPVWVVYAEYETVEDAKNALTKLHGNSTYFHGAAPILAKFEDSEDAKRERRRRRDGTQTHAPNSGCIFPPPHSHHESGGPLQSAASTLNTESDGTHSHVFGSNRIMETKTSPKGTVAPRRSGTSGIGSATPGLPLPNGPLLPPPPPPPSFLSAMSDVAKQTQAPAFSMPQQLLQPTPGYCYTLGESGQQIFIPASSFTGPLPTYNFPSTAQSAPVLLVNAPMQATGAAVKPDFPVLNPTASPPMMMMENGHQYMLASDTVNMSCESFTSLTSTLSPVLTVSQPKSLLGVNSSQTTYTSGNCGSMSAFSPFHDAVFAEPLQAVLPRSETGDQPIGEAGAAGFNVDGARAHTPQGLTSERSMITGQLGSRVVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GW11</accession>
    <name>A0A836GW11_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_00661</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058839.1">
        <property type="nucleotide sequence ID" value="XM_067202738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GW11"/>
    <dbReference type="SMR" id="A0A836GW11"/>
    <dbReference type="GeneID" id="92356672"/>
    <dbReference type="KEGG" id="loi:92356672"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5465208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="184" mass="21196" checksum="1AC6313ABA1ADC49" modified="2021-09-29" version="1">MVLNKWAVVTKSAPPAAGLRPLARMVSPNPKLRPADYKVPYVLRTFIKDRHLSEVQHIENRGMYREELAIERSRFPRMHKTLTIQTDGSLNEREFEFAVPPVVTLFRDRLSAHRQRQVALAKIGKLKRAKSWETTVRGKDSLNPVCNALVFPYCVPKKMLVRPRIVDPLSAKSLADSRRRREDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GWE0</accession>
    <name>A0A836GWE0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">CTP synthase</fullName>
            <ecNumber evidence="3 13">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LSCM4_06135</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">LSCM4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 13">
            <text>UTP + L-glutamine + ATP + H2O = CTP + L-glutamate + ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the CTP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="3 13"/>
    <dbReference type="EMBL" id="JAFHLR010000020">
        <property type="protein sequence ID" value="KAG5480369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063700.1">
        <property type="nucleotide sequence ID" value="XM_067208060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GWE0"/>
    <dbReference type="SMR" id="A0A836GWE0"/>
    <dbReference type="GeneID" id="92361994"/>
    <dbReference type="KEGG" id="loi:92361994"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097268">
        <property type="term" value="C:cytoophidium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019856">
        <property type="term" value="P:pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000009">
        <property type="entry name" value="CTP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000002">
        <property type="entry name" value="CTP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003792">
        <property type="entry name" value="PRK05380.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="CTP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550:SF0">
        <property type="entry name" value="CTP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 13" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 13" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP synthase N-terminal" evidence="15">
        <location>
            <begin position="30"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase" evidence="14">
        <location>
            <begin position="342"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU810713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG5480369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="596" mass="66039" checksum="BDDA13D45D1FB91D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GX81</accession>
    <name>A0A836GX81_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067205616.1"/>
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    <dbReference type="KEGG" id="loi:92359550"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="14"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5473550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="269" mass="29907" checksum="065BEB8AF07FFD5E" modified="2021-09-29" version="1">MATFTEAELAPSAIAAERERLRETSQHVADLEKQLDALQKELEVARTRREKLRLSVQWRELMAAVNADEEVYAVVERLTGAFAAFRESLVEPENYRQEQKEEVPNVDDIVPYSDTDDYADFSGVETAVEELLAALREQLESHAATPPLSSRLSKRTSSCGSLAVNEKPDCPAGKLAGTHKAKAVVRRKALLKLLVITVLIGRVEQYCGFKSISDAGNVPQPDAEEIRDGVASVWQWILHEQSELLTAAENAEWKEIVITFLGESYAMPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GXE7</accession>
    <name>A0A836GXE7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cytidyltransferase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000017">
        <property type="protein sequence ID" value="KAG5481904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064264.1">
        <property type="nucleotide sequence ID" value="XM_067208890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GXE7"/>
    <dbReference type="SMR" id="A0A836GXE7"/>
    <dbReference type="GeneID" id="92362824"/>
    <dbReference type="KEGG" id="loi:92362824"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051182">
        <property type="entry name" value="Euk_NMN_adenylyltrnsfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039:SF0">
        <property type="entry name" value="NICOTINAMIDE-NUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="1">
        <location>
            <begin position="58"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5481904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="317" mass="35044" checksum="9453F453429D9186" modified="2021-09-29" version="1">MKQQNCRGSAECCLLELPYTLRTDKLKPLQDCLGGCPTSATDAASQSAPLPQPVVLAICGSFNPIHYAHLKLYDAAKECVDGTNDRVVLGGFLSPVGDAYVKPGLRCAADRVRIMQRVLRGHSDLSVDTWECQQPTYTRTFFVLQALEEHVNQWYARAEPAAMQWLVSHERRVRVVFVCGADLFSSFWTPGCWPLRLLRQLLDTFPLVVVHRGDARGGVRGADDFVRVCRTTPLLSETAEDGERVEIDMSRYTFTFTTFTEADNTSSTAVRGAVMKLAKTPLDDVVARAALWSRLCAMLPEAAVQLVVDLYGDGPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GZV8</accession>
    <name>A0A836GZV8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_07902</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">LSCM4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000013">
        <property type="protein sequence ID" value="KAG5484336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064829.1">
        <property type="nucleotide sequence ID" value="XM_067209779.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92363713"/>
    <dbReference type="KEGG" id="loi:92363713"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115:SF1016">
        <property type="entry name" value="KINESIN FAMILY MEMBER 19A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115">
        <property type="entry name" value="KINESIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="4">
        <location>
            <begin position="677"/>
            <end position="1396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="180"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="289"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="381"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="812"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="887"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1019"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1228"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="522"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="636"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="204"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="250"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="289"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="381"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="420"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="828"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="897"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1037"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="794"/>
            <end position="801"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5484336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1431" mass="153194" checksum="EEDD160F938EF38D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H2N2</accession>
    <name>A0A836H2N2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_02653</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060232.1">
        <property type="nucleotide sequence ID" value="XM_067204680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H2N2"/>
    <dbReference type="GeneID" id="92358614"/>
    <dbReference type="KEGG" id="loi:92358614"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030865">
        <property type="term" value="P:cortical cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035303">
        <property type="term" value="P:regulation of dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039865">
        <property type="entry name" value="PPP2R3C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12085:SF4">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12085">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B'' SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="370"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5469255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="553" mass="62518" checksum="D323CAD6A7BD386C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H3D5</accession>
    <name>A0A836H3D5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Serine/threonine-protein kinase ATR</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LSCM4_02820</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PI3/PI4-kinase family. ATM subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060392.1">
        <property type="nucleotide sequence ID" value="XM_067204840.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92358774"/>
    <dbReference type="KEGG" id="loi:92358774"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00892">
        <property type="entry name" value="PIKKc_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000065">
        <property type="entry name" value="PIKK family atypical protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000054">
        <property type="entry name" value="Putative phosphatidylinositol 3-related kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057564">
        <property type="entry name" value="HEAT_ATR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF69">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23593">
        <property type="entry name" value="HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="126"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="14">
        <location>
            <begin position="2867"/>
            <end position="3183"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="15">
        <location>
            <begin position="3176"/>
            <end position="3208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="887"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1417"/>
            <end position="1448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="887"/>
            <end position="899"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG5470126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="3208" mass="352108" checksum="39B9582A701846E8" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H414</accession>
    <name>A0A836H414_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_03944</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061874.1">
        <property type="nucleotide sequence ID" value="XM_067205937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H414"/>
    <dbReference type="SMR" id="A0A836H414"/>
    <dbReference type="GeneID" id="92359871"/>
    <dbReference type="KEGG" id="loi:92359871"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="65"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5474768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="571" mass="59117" checksum="7AF4BB8C2D374004" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H417</accession>
    <name>A0A836H417_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNL-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_04428</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062621.1">
        <property type="nucleotide sequence ID" value="XM_067206412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H417"/>
    <dbReference type="SMR" id="A0A836H417"/>
    <dbReference type="GeneID" id="92360346"/>
    <dbReference type="KEGG" id="loi:92360346"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024158">
        <property type="entry name" value="Mt_import_TIM15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007853">
        <property type="entry name" value="Znf_DNL-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20922">
        <property type="entry name" value="DNL-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20922:SF13">
        <property type="entry name" value="DNL-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05180">
        <property type="entry name" value="zf-DNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51501">
        <property type="entry name" value="ZF_DNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNL-type" evidence="6">
        <location>
            <begin position="141"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="63"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5477210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="234" mass="24700" checksum="2A95C1FED986AF33" modified="2021-09-29" version="1">MLHRPELLSVPRRLAVFRSWHIGARAVSALGPILQPALRAQSSCTSLSTVSLAAASRRWCSNGCSSSDPSSPGHSRAKAPSNTAAAASTGLATHQAATDSVTPVAEQLKILSPEDQQRIITALQAPEKEKSSVMGGAGIGPADGDMVAAFTCGPCDYRMVKRFSKHAYTKGIVIVECPNCRAKHLLADNLGWMEDTAINIEDILKAKGESFIRIGGTEGDYQVMVDPSEAASPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H426</accession>
    <name>A0A836H426_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_04443</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062636.1">
        <property type="nucleotide sequence ID" value="XM_067206427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H426"/>
    <dbReference type="SMR" id="A0A836H426"/>
    <dbReference type="GeneID" id="92360361"/>
    <dbReference type="KEGG" id="loi:92360361"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036339">
        <property type="entry name" value="PUB-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143503">
        <property type="entry name" value="PUG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5477225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="442" mass="48828" checksum="45B53E46F2970DBC" modified="2021-09-29" version="1">MNSDVVQVAATAEVSKLSVPLLITCLHASAISAPLAEVCRAFSIIERLLSNRVQHPSEPRYTSFSATSTAWVNSVLPLVYVFRLTVWMGCTLTAEGTRYVFNDSLGDTNTPGPSDAEVRRQRWGQQQLLDRLDELRCVASVWSTSAAEASGDAARRYQAAYQQLLKLFQPIQNSTDREKMWARHIDRLLLYRLLACAGDVERRQATATSPAASGAPRRECVASWVARAQHELDGSSHVPGSAPLSDGQGASMTRALPVLEALHGPCRESEALAMCVADDSLQWLLSHASLCELRRMCERATAECAARSVDSRESGSSSVVPLLPGFSAAVADRLRQRAQLEQHQQYLGTTGPAYRRLSHEERHRGESLIIGIAALLEQIAVVTETQGMVRHDRHEARRLLDGFRQDGDLAKLYALEERYTAELEEAKLRYGKPLVYAALFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H5T2</accession>
    <name>A0A836H5T2_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5478110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063017.1">
        <property type="nucleotide sequence ID" value="XM_067207449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H5T2"/>
    <dbReference type="GeneID" id="92361383"/>
    <dbReference type="KEGG" id="loi:92361383"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5478110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="147" mass="16307" checksum="BE878AFF9ED73DDF" modified="2021-09-29" version="1">MGHTVSRNKPQAEKMAAAMNTNEVSSPIMTESDAQMGAAAQEKLRRLDSEQCLTEEMIEGLTRSSTASTRSKAQKKDALNDWIAAANYVVEHDMDALKQHEDSMHALAGMQKAKHELRCFSKLDHCSSSRSKDSKRKGTHDTLKSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H6I0</accession>
    <name>A0A836H6I0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1935 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_06204</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000020">
        <property type="protein sequence ID" value="KAG5480437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063768.1">
        <property type="nucleotide sequence ID" value="XM_067208128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H6I0"/>
    <dbReference type="SMR" id="A0A836H6I0"/>
    <dbReference type="GeneID" id="92362062"/>
    <dbReference type="KEGG" id="loi:92362062"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015232">
        <property type="entry name" value="DUF1935"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036310">
        <property type="entry name" value="Smp-1-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09149">
        <property type="entry name" value="DUF1935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101601">
        <property type="entry name" value="Smp-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1935" evidence="2">
        <location>
            <begin position="93"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5480437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="189" mass="20227" checksum="642A283B81390AE2" modified="2021-09-29" version="1">MGCGLSTQKAAAGAFTSSVKALSVDMKTRFATVDQEVLGPHKEVATANLAFVYGKTANIFLLTTPPFHKPPPRPRPEGEERAAEEGESEAPATEEVRWTFFNDSKSDSIVEATFFRARGLRAARAHGAAEDTASHVKLELSDGGRVKAEVTVPAGATVAFVEGPINGYMWKCVVLDSKTNRFEPATAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H6J4</accession>
    <name>A0A836H6J4_9TRYP</name>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
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            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
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        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
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                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="KEGG" id="loi:92359455"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        </source>
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</entry>
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        <name type="scientific">Leishmania orientalis</name>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="1">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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        </submittedName>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5483047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="936" mass="100040" checksum="6E5E815377CF8AE5" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HBR5</accession>
    <name>A0A836HBR5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_04781</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000023">
        <property type="protein sequence ID" value="KAG5478548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063209.1">
        <property type="nucleotide sequence ID" value="XM_067206762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HBR5"/>
    <dbReference type="GeneID" id="92360696"/>
    <dbReference type="KEGG" id="loi:92360696"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="6">
        <location>
            <begin position="123"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5478548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="302" mass="35356" checksum="CE0E883387E65562" modified="2021-09-29" version="1">MDFAFRLFTSVIPVDREKVTHQMLIFWLILTTGGISMYLLFSSISYWIYFRTLKRQFFPKTIDPDDAHKLREQVRHEIWIAVCSIPFMAFLMMPAATFSHRGYSKLYHNVSDYGWTYALVSPVLFFAFTDFMVYCFHRGLHHPIIYKHVHKLHHTYKYTTPFSSHAFNPVDGFGQGVPYYIFVYLFPLHSVLFIALFVAVNFWTISIHDQVDFGGHFINTTGHHTIHHELSNFDYGQYTTVWDRLGGSYRPAEQTHQLSSLLRAGDSNYTDPVYATYHEERGFLAGRFKEEAAARRSKKIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HD85</accession>
    <name>A0A836HD85_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_04213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062139.1">
        <property type="nucleotide sequence ID" value="XM_067206202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HD85"/>
    <dbReference type="SMR" id="A0A836HD85"/>
    <dbReference type="GeneID" id="92360136"/>
    <dbReference type="KEGG" id="loi:92360136"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5475631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="666" mass="74586" checksum="9E6EC1C31B4BA073" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HDC0</accession>
    <name>A0A836HDC0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Threonylcarbamoyl-AMP synthase</fullName>
            <shortName evidence="13">TC-AMP synthase</shortName>
            <ecNumber evidence="3 13">2.7.7.87</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 13">L-threonylcarbamoyladenylate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LSCM4_03967</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:36407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="EC" id="2.7.7.87"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the SUA5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.87" evidence="3 13"/>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061896.1">
        <property type="nucleotide sequence ID" value="XM_067205959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HDC0"/>
    <dbReference type="SMR" id="A0A836HDC0"/>
    <dbReference type="GeneID" id="92359893"/>
    <dbReference type="KEGG" id="loi:92359893"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061710">
        <property type="term" value="F:L-threonylcarbamoyladenylate synthase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.870.10:FF:000009">
        <property type="entry name" value="Threonylcarbamoyl-AMP synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11030">
        <property type="entry name" value="Threonylcarbamoyl-AMP synthase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="Sua5-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038385">
        <property type="entry name" value="Sua5/YwlC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005145">
        <property type="entry name" value="Sua5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010923">
        <property type="entry name" value="T(6)A37_SUA5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050156">
        <property type="entry name" value="TC-AMP_synthase_SUA5"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00057">
        <property type="entry name" value="L-threonylcarbamoyladenylate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490">
        <property type="entry name" value="SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490:SF16">
        <property type="entry name" value="THREONYLCARBAMOYL-AMP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03481">
        <property type="entry name" value="Sua5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004930">
        <property type="entry name" value="Tln_factor_SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="YrdC/RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="YrdC-like" evidence="15">
        <location>
            <begin position="9"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015492"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR004930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR004930-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG5474790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="386" mass="41234" checksum="F7C233E058BBA72B" modified="2021-09-29" version="1">MAQIIGTSPEDLRRAADALLQGKLVAIPTETVYGLGGNALIENAAKKIYAVKGRPPTDPLICHVYSLDGVRRLWDLKWDEGAVELACTIGGALWPGPLTIVCKANPSLPDCVTGGSGYVGARIPNNATTLKLLEIVDVPVAAPSANTFGHVSPTTAQHVYDDLAARDPELLIIDGGQSAIGIESTVAKVESKDSVVVLRRGCITVSMIHRSIADRYPQTRVEIRDARIVCDPTKAPMVSPGQLLTHYSPRVPSSLLTPGSMAALTASADAPIYVHRGQDVVPLSETIVLDFNGHLYRFRDSCLSYHDMSPDGNPEEGCYAVFDALRATEAVKGAKNLVFPLISEWPHDKDNEDLLAAMEDRLFRAASGVTAVLINSAAPASGRHSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HDP1</accession>
    <name>A0A836HDP1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_04015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061944.1">
        <property type="nucleotide sequence ID" value="XM_067206007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HDP1"/>
    <dbReference type="SMR" id="A0A836HDP1"/>
    <dbReference type="GeneID" id="92359941"/>
    <dbReference type="KEGG" id="loi:92359941"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5474838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="29416" checksum="65A2F2920FCFCD9B" modified="2021-09-29" version="1">MPRHSKYVRMTSVAVVLAVIGLAALSCTPALCISATEPASFELSRLLERIPQMSAAAKAFPPYALPQIARLNGDTPQMEPAQTFLVEPVHDDASKIRAVSPDVITTGAAAAASAEQLHKLPTSLSAQLLHSPLANGEVVHPLVQLHKASPSLPIHQRQQLVLSSYRAAGHLSAQQDGNKAVAVEVTATSKRTITDTSSASEGDSSSEAIYGTILSGGVIASFTAALVFASVLLTFVLVEVCAMISAFMERRRMRAARQTKDAADLAEPRYGDAVADAHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HIB6</accession>
    <name>A0A836HIB6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_04589</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">LSCM4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062781.1">
        <property type="nucleotide sequence ID" value="XM_067206572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HIB6"/>
    <dbReference type="SMR" id="A0A836HIB6"/>
    <dbReference type="GeneID" id="92360506"/>
    <dbReference type="KEGG" id="loi:92360506"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF478">
        <property type="entry name" value="PALMITOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="8">
        <location>
            <begin position="115"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5477370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="327" mass="36010" checksum="C034467F22CA066D" modified="2021-09-29" version="1">MPLSAPLRRDGNITVLFNGRIFVGPDWRIMTVSVVLIAGCSLLFVFYTNEVMAARVIVGVTALISLAVLLLCGLSDPGVQPRQPPPPPDAPPHESLWREREYVDHNGDIHQARLEMKWCYSCNIYRPYRGVHCRYCDRCVARRDHHCPWTGTCIGAKNYRSYFVLVWVLSVMLLSALCGGIQSFAQRVVRHGKTPSAIKDGPSAFTSALIDTYCVELILIVLSFVFGLLAWSLAAYHTYLISRNLTSGDAAKDLEENVFTHGSVLANLWAAMTGWRDEEMACGVARAEVVIETGGCDDVSDGPSPFAETNAASSHATLCHDCDAERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HJB6</accession>
    <name>A0A836HJB6_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_07751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000006">
        <property type="protein sequence ID" value="KAG5487262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065759.1">
        <property type="nucleotide sequence ID" value="XM_067209629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HJB6"/>
    <dbReference type="GeneID" id="92363563"/>
    <dbReference type="KEGG" id="loi:92363563"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5487262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="300" mass="32289" checksum="481D69FC1BC1069A" modified="2021-09-29" version="1">MSSHAFSSGSAPNVSSATIGTAAQQADSRTRNFILGIPKEGLSPNSPEAADLQAAEAFVSDIQQEILAYDIANAKAIESYAVRWWSAVPFFGRHAKRALEAEAAAEQARESTEAATAAVDGEASSSGGHGLHLSPEEAAAALKSGGTFLHRQTTQTPRGLKVERTSAIDQAQLSQLSNGAGRALGAKAASAPAASASTKTVFAPTVNTWLFRRQHPSWVPLMQRWWVPWLCTVSIVLIWTPDVWKLRTLCFCDHQYALLRQSVHQAYWWATMKPEDYAAHMADIAAARPSRVGGTSCPFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HJZ6</accession>
    <name>A0A836HJZ6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="11">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LSCM4_05446</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="11"/>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5478048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062955.1">
        <property type="nucleotide sequence ID" value="XM_067207387.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836HJZ6"/>
    <dbReference type="GeneID" id="92361321"/>
    <dbReference type="KEGG" id="loi:92361321"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17920">
        <property type="entry name" value="DEXHc_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18794">
        <property type="entry name" value="SF2_C_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000958">
        <property type="entry name" value="ATP-dependent DEAD/H DNA helicase recQ, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.80:FF:000026">
        <property type="entry name" value="ATP-dependent DEAD/H DNA helicase recQ, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000296">
        <property type="entry name" value="ATP-dependent DNA helicase RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="entry name" value="HRDC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF153">
        <property type="entry name" value="RECQ-LIKE DNA HELICASE BLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="568"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="764"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="67"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="146"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1108"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1180"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1249"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1475"/>
            <end position="1499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1511"/>
            <end position="1567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1800"/>
            <end position="1846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="2003"/>
            <end position="2054"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="285"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="160"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="426"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1195"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1215"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1249"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1288"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1536"/>
            <end position="1545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1800"/>
            <end position="1809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="2016"/>
            <end position="2026"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG5478048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="2054" mass="214614" checksum="8D1AB9D8FC343385" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HLV6</accession>
    <name>A0A836HLV6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tubulin--tyrosine ligase-like protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_06152</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">LSCM4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-glutamyl-[protein] + L-glutamate + ATP = gamma-L-glutamyl-L-glutamyl-[protein] + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60144"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:15517"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:143622"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:60145"/>
        </physiologicalReaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000020">
        <property type="protein sequence ID" value="KAG5480386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063717.1">
        <property type="nucleotide sequence ID" value="XM_067208077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HLV6"/>
    <dbReference type="SMR" id="A0A836HLV6"/>
    <dbReference type="GeneID" id="92362011"/>
    <dbReference type="KEGG" id="loi:92362011"/>
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        <property type="term" value="C:ciliary basal body"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
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    </dbReference>
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        <property type="entry name" value="TTL"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="130"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="669"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5480386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="766" mass="80962" checksum="567D80576DFB2BFD" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HP22</accession>
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            <fullName evidence="3">Serine peptidase</fullName>
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        <name evidence="1" type="ORF">LSCM4_07696</name>
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        <name type="scientific">Leishmania orientalis</name>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000012">
        <property type="protein sequence ID" value="KAG5484923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF81">
        <property type="entry name" value="PROTEIN ABHD13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5484923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="616" mass="68789" checksum="37C1C3AFA431DA16" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HPH3</accession>
    <name>A0A836HPH3_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">LSCM4_06109</name>
    </gene>
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        <name type="scientific">Leishmania orientalis</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000020">
        <property type="protein sequence ID" value="KAG5480343.1"/>
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    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="loi:92361968"/>
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        <property type="component" value="Chromosome 20"/>
    </dbReference>
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        <location>
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            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="390"/>
        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5480343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="390" mass="41644" checksum="926CE6A5D345DB5D" modified="2021-09-29" version="1">MQFVFVVKGRDAGVPQTLAADRLFVAASRETAHRSRHARDRGNRKYSAAAHTPGAPLQISGSRLRDLCWRESPLSSSLPMGKEDLKFNCVMVQAPYAARASDGDLGPAPLRVIAGDALEHIFFNVNEDLLQDGRLVVFTYAENLLNVSIDADVWAENRVAATGASSGVAVSAGDGSTRACGSADGPEAEGATNERLSLNNDGGAAAGLAKRPRRGDLVGGEEELSRASRRLDSPHSSLRKEQVLAVVPSAVNGDDIKELNELIDEGKLSTLDASLTDFFCCQCYHLPLLTLTMSCCGAVLCQHCAPTPPTVEGVSATDRACPICGEEPLDPPISHLTRDAKAAKLVKELKVLYFPQLRALRESRQASTNPSTPSTPPFLLRNTPVLGPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HZF5</accession>
    <name>A0A836HZF5_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000010">
        <property type="protein sequence ID" value="KAG5485680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065264.1">
        <property type="nucleotide sequence ID" value="XM_067208553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HZF5"/>
    <dbReference type="GeneID" id="92362487"/>
    <dbReference type="KEGG" id="loi:92362487"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5485680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="199" mass="21489" checksum="43DC51784DDA9FA7" modified="2021-09-29" version="1">MACGSVCDTFLSFLRKFFSLILAISIAFMTLLYVVGAGVVTTRAKSFSKSGFAHFLGIVFAIASVIGYLFLHFVPRKAYRLLYGVTFLMLTTVFLVSHSMGLAAPVVADCSAANSLHFTGNYTGIGSIGSILDDDNNNITIGRLGEPVAQCKSNALLFAAAFINMFLYVIALFDVQTVLLARVKSKTYGERFVEMGISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836I5F0</accession>
    <name>A0A836I5F0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pseudouridylate synthase RPUSD4, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">RNA pseudouridylate synthase domain-containing protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_08325</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a uridine in tRNA = a pseudouridine in tRNA</text>
            <dbReference type="Rhea" id="RHEA:54572"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13934"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>uridine in 5S rRNA = pseudouridine in 5S rRNA</text>
            <dbReference type="Rhea" id="RHEA:47036"/>
            <dbReference type="Rhea" id="RHEA-COMP:11730"/>
            <dbReference type="Rhea" id="RHEA-COMP:11731"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000001">
        <property type="protein sequence ID" value="KAG5488248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066295.1">
        <property type="nucleotide sequence ID" value="XM_067210194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836I5F0"/>
    <dbReference type="SMR" id="A0A836I5F0"/>
    <dbReference type="GeneID" id="92364128"/>
    <dbReference type="KEGG" id="loi:92364128"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF83">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE RPUSD4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="8">
        <location>
            <begin position="173"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5488248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="413" mass="47174" checksum="AE5A21BF0C380934" modified="2021-09-29" version="1">MRRFALLLAWQPSFVKHVSDLEPAPQKVPVEKRRRQHVSLSLRAREELSRKSGELQYHVVTQDWFGQRVDDFVTQHHPEWDYETVRRLVQAGHIYRYRKNGKRRYTRLTDRLEFDELVVVPTAGFWERQIAPPSGVVRQSSSTAQQQERRQNFRLSAKAREMAQEMVLFKNEHVVVINKPSGVPMMQTHDPLAMNITDLLPAWRYTNTQTPIVCHNLDAETSGCVVLARSANAHRMLGRMFVKRVVPNSVYWGFAVGKPPVNFGRIRMHFEVQKGQGGDVIVARPTPTANSKVGIAEFVVNASALEFGSFISFYPLTTRRHQERIMAAHALRAPLLGDAKYGGESAFPHSLSLFWDPARKDVPLHLHHRKVQLPYKNSAGEFVCVTAPLPSHMEKTFKRLGWPVDADDPLIPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836K920</accession>
    <name>A0A836K920_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glycerol kinase</fullName>
            <ecNumber evidence="3">2.7.1.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LSCM4_00024</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="3"/>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058217.1">
        <property type="nucleotide sequence ID" value="XM_067202116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836K920"/>
    <dbReference type="SMR" id="A0A836K920"/>
    <dbReference type="GeneID" id="92356050"/>
    <dbReference type="KEGG" id="loi:92356050"/>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004856">
        <property type="term" value="F:D-xylulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005997">
        <property type="term" value="P:xylulose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07808">
        <property type="entry name" value="ASKHA_NBD_FGGY_EcXK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02220">
        <property type="entry name" value="XylB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050406">
        <property type="entry name" value="FGGY_Carb_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006000">
        <property type="entry name" value="Xylulokinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01312">
        <property type="entry name" value="XylB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43095">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43095:SF6">
        <property type="entry name" value="XYLULOSE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="11">
        <location>
            <begin position="1"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="12">
        <location>
            <begin position="249"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG5464586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="487" mass="53789" checksum="10A2F2B9873CBB0A" modified="2021-09-29" version="1">MYAGIDIGTSGIKIALMKSDGQIVDSASAPLTVSSPHPLWNEQDPNLWWTAINTAMDELTKRQDMSSVRAIGLSGQMHGATLLDKNHKVLRPCILWCDGRCYRECEELEKAVPNSREMTGNLMMPGFTAGKLLWVKKHEPEVFAKVDKVLLPKDYIRFLMTGDFASEMSDASGSMWMNTGERDWNDDILRATGLSRAAMPKLYEGSEITGRLSADVAKRWNMKRVPVVGGGGDNEAGAVGAGVFKPGQAMLSIGTSGVYFVVSDGFHYNTKEAVHSFCHALPQRWHLMSVILSCAVCLDWAAKLTGCENVGEFVSEATKAKNFDDRPVYFLPYLAGERTPHNNPNAKGVFFGLTSHHGRPELARAVLEGVSFAMAQGMDAVHRCGVQPTSIVLIGGGSRSRFWRQMLADVSGYPMNYCVGSEVGPALGACRLAQIAVEKRPLEELLPQLPLKETHIPNVQKHNQYKKRRVIYEDLYKRLKPVMRANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836K9I8</accession>
    <name>A0A836K9I8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_00670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058847.1">
        <property type="nucleotide sequence ID" value="XM_067202746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836K9I8"/>
    <dbReference type="SMR" id="A0A836K9I8"/>
    <dbReference type="GeneID" id="92356680"/>
    <dbReference type="KEGG" id="loi:92356680"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000076">
        <property type="entry name" value="Chaperone protein dnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000013">
        <property type="entry name" value="DnaJ subfamily B member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000015">
        <property type="entry name" value="Heat shock protein 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051339">
        <property type="entry name" value="DnaJ_subfamily_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078:SF553">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="4"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5465216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="344" mass="37582" checksum="427CB6217248C0DE" modified="2021-09-29" version="1">MGVDYYKVLGVSRNAKPNEIKKAYHQLALKYHPDKNADNREKAERKFKEVSEAYDVLSDEKKKKIYDLYGEEGLKGGIPEDGGAGMGGAGMHSGGVGSMPGGFHGATYQFSSTDAFKIFNQFFGSSDPFAGGEAFGGGGPGLHRVFRGYGGPEGFASGFGTPQSSPMSDVPPMEYTFACTLEEIYTGCTKKFNVSRNMPSGAEKKMFEVKVLPGYKKGTKIRFEREGGRVEGYPPNVLADMVFILDERPHPRFERHGADLHTTLHINLKQALLGSTVFVKGIDGKTISLPLTGVSKSGRKLRVSGSGMPDRKTNRNGDLYVTIAVDFPESLTDDTKRLIEQCRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KA83</accession>
    <name>A0A836KA83_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_00148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058338.1">
        <property type="nucleotide sequence ID" value="XM_067202237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KA83"/>
    <dbReference type="GeneID" id="92356171"/>
    <dbReference type="KEGG" id="loi:92356171"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5464707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="603" mass="64107" checksum="E675B3792B57F9E2" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KAB7</accession>
    <name>A0A836KAB7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="6">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_00268</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="6">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="6"/>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058458.1">
        <property type="nucleotide sequence ID" value="XM_067202357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KAB7"/>
    <dbReference type="SMR" id="A0A836KAB7"/>
    <dbReference type="GeneID" id="92356291"/>
    <dbReference type="KEGG" id="loi:92356291"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00268">
        <property type="entry name" value="DEADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002928">
        <property type="entry name" value="DEAD/DEAH box helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044742">
        <property type="entry name" value="DEAD/DEAH_RhlB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="234"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="573"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="30"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="99"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="147"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="515"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="743"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="515"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5464827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="782" mass="85503" checksum="17BE45CA5EFB9110" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KBM5</accession>
    <name>A0A836KBM5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Galactokinase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_01458</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GHMP kinase family. GalK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059202.1">
        <property type="nucleotide sequence ID" value="XM_067203511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KBM5"/>
    <dbReference type="SMR" id="A0A836KBM5"/>
    <dbReference type="GeneID" id="92357445"/>
    <dbReference type="KEGG" id="loi:92357445"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000705">
        <property type="entry name" value="Galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019741">
        <property type="entry name" value="Galactokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006206">
        <property type="entry name" value="Mevalonate/galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF7">
        <property type="entry name" value="GALACTOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457">
        <property type="entry name" value="MEVALONATE KINASE/GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000530">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00473">
        <property type="entry name" value="GALCTOKINASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00959">
        <property type="entry name" value="MEVGALKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00106">
        <property type="entry name" value="GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Galactokinase N-terminal" evidence="6">
        <location>
            <begin position="38"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="4">
        <location>
            <begin position="124"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="5">
        <location>
            <begin position="363"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5466312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="476" mass="53248" checksum="462B49EDD1FF6CE8" modified="2021-09-29" version="1">MPGESYSDERLDGTLATLAPIFRQEFQVVNDADVQWLLFTFSPGRVNLIGEHVDYMEGWTCPAAVLEGTHILVGRVRHFQNEAKPKLRFYATYTMEHFEIDHLGGDKHNKAWTTFVRGAVTLRLNRLGVTIDDPSLSGVCMVVHSTLAMGAGMSASAAFGVALIHAINAVVTKSYKGCPISTGRRYSVLPAMPRQELVELAKEARLIETEYCGVNIGIMDQFISALAEADKFMFLDCKNLTFETIDMKPLLGNGEYSWMLIDSMIKHDLLSETAQVYNAVRSDQENAQKKIGEHRYRGKPYSFSMMVRNPLEYGFDGDVEKFMAEFKPLMSPGEFERGTYQIMEQLRTLEFRRVNDAATPLSREERVRKVGEILNAGHAGMRDLLKVTTPELDYIQQLINEDKDVAGGRMMGGGFGGCIILLLRSSAEDRVLAHVREHFKARFKVENTCYKVKRVGSGGFVVSLEGKNVNGAVSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KBN0</accession>
    <name>A0A836KBN0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_01474</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059217.1">
        <property type="nucleotide sequence ID" value="XM_067203526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KBN0"/>
    <dbReference type="GeneID" id="92357460"/>
    <dbReference type="KEGG" id="loi:92357460"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF35">
        <property type="entry name" value="KINASE A, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="15"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5466327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="740" mass="79678" checksum="4439442D8DF92EA2" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KBQ8</accession>
    <name>A0A836KBQ8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TatD related DNase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_00438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058621.1">
        <property type="nucleotide sequence ID" value="XM_067202520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KBQ8"/>
    <dbReference type="GeneID" id="92356454"/>
    <dbReference type="KEGG" id="loi:92356454"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47176:SF1">
        <property type="entry name" value="OS04G0577500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47176">
        <property type="entry name" value="OSJNBA0020J04.13 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5464990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="446" mass="47312" checksum="FE976FD637DEB11B" modified="2021-09-29" version="1">MSRRAAPTWEGQENMLRPSECPLVYDFLYDSHCHLRRISPSAPATAVPGPFTSVSGAGGPCNCTPCTVTGLVLCGTHPSIDWDAIAQASATRAATLIGFGVHPWFVPNATSSPEDAEPSRVAEGSPTSSLSPVNCSGGACRSSSSSGAETNANLAAPGAVAPMLPIILRLLRERLQQHPSAIVAEIGLDKLRGPPESVQVEAFAAQLRLAAAYRRPVSVHCVRHYGLLLQLLRDLPAEHTPPAIILHAFTGSLDVAKSLLSLKNKKPMPAAGGAATPSRDAVAAEDSSSATLKRIKRGGATAEMVRIKDFIFFGVGVSTSFAVKSFATQTLPFLLDARRVLLETDEHYSGIEAQAAVSAGEFHAEEETQLSPRSRFSARVRVDPREHITKLAGVLERVHAAMLESRDFVKKAEASSVSVEVVIRDALLHAYSAAFRSVSEETGALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KD81</accession>
    <name>A0A836KD81_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_01702</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059440.1">
        <property type="nucleotide sequence ID" value="XM_067203749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KD81"/>
    <dbReference type="SMR" id="A0A836KD81"/>
    <dbReference type="GeneID" id="92357683"/>
    <dbReference type="KEGG" id="loi:92357683"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07831">
        <property type="entry name" value="STKc_MOK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000700">
        <property type="entry name" value="CMGC/RCK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000271">
        <property type="entry name" value="MAPK/MAK/MRK overlapping kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="4"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="298"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5466550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="392" mass="44106" checksum="86586AB17F4A98FE" modified="2021-09-29" version="1">MQKYQILGKKGEGTFSEVLRAQDIKTQRYVAIKCMKKAFKSKEQVNRLREIQAVRRLQPHPNIVDLVEVLFDRSTGRLALVLELMDMNLYELIKGRKQYLGEEKVRSYMYQLLKGLDHAHRIGVFHRDIKPENLLIDAEGHLKIADFGSCKGVYSKLPLTEYISTRWYRAPECLLTDGYYSYKMDLWSAGCVFFEIIALFPLFPGSNELDQVHRIHNVLGTPPAEILDRLKKSGTHMDYDFPKKQGTGLAKLLPHVSAEALDLMKKLLTYDEEQRCTAKEALRHAYFSKLREADKKSRRLKHSAGCSRPATVTDDVHGSTGLSSSPRKAANGMPSLSSTLTASRKLPVIDGVSPTKSCTFTSNHSILHQVHGAVATSASGEDLNAQSLPKLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KDW4</accession>
    <name>A0A836KDW4_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061095.1">
        <property type="nucleotide sequence ID" value="XM_067204058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KDW4"/>
    <dbReference type="GeneID" id="92357992"/>
    <dbReference type="KEGG" id="loi:92357992"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5472699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="594" mass="64258" checksum="29010A9B8081367A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KET8</accession>
    <name>A0A836KET8_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_03669</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061602.1">
        <property type="nucleotide sequence ID" value="XM_067205665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KET8"/>
    <dbReference type="GeneID" id="92359599"/>
    <dbReference type="KEGG" id="loi:92359599"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5473599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="534" mass="55905" checksum="E18D3B2BBE72B188" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KGJ3</accession>
    <name>A0A836KGJ3_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_00179</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058369.1">
        <property type="nucleotide sequence ID" value="XM_067202268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KGJ3"/>
    <dbReference type="GeneID" id="92356202"/>
    <dbReference type="KEGG" id="loi:92356202"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45153">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 16"/>
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                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <dbReference type="InterPro" id="IPR039136">
        <property type="entry name" value="NUFIP1-like"/>
    </dbReference>
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        <property type="entry name" value="Zn_knuckle_CX2CX3GHX4C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13309:SF0">
        <property type="entry name" value="FMR1-INTERACTING PROTEIN NUFIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13309">
        <property type="entry name" value="NUCLEAR FRAGILE X MENTAL RETARDATION PROTEIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13696">
        <property type="entry name" value="zf-CCHC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="58"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="242"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="447"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="250"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="323"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="450"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="533"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="551"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5473437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="632" mass="69112" checksum="956535C68DC81FF0" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KI12</accession>
    <name>A0A836KI12_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_03611</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061545.1">
        <property type="nucleotide sequence ID" value="XM_067205608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KI12"/>
    <dbReference type="GeneID" id="92359542"/>
    <dbReference type="KEGG" id="loi:92359542"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5473542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="121" mass="13121" checksum="834D78949DB3767A" modified="2021-09-29" version="1">MQGRKDTPISSSCGGTLRIRTALLESLCRYNEAMLNSSSAAEEPLATSAQRVDKVPDALPRMIAQLSPCLTNPSWAMEECVRLCPAAEVWCGTALPKDVWAPPGTPECPFGTEPMDFNAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KIB0</accession>
    <name>A0A836KIB0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase M20 dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_03293</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067205305.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="loi:92359239"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05682">
        <property type="entry name" value="M20_dipept_dapE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051458">
        <property type="entry name" value="Cyt/Met_Dipeptidase"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270">
        <property type="entry name" value="BETA-ALA-HIS DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270:SF4">
        <property type="entry name" value="CARNOSINE DIPEPTIDASE 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="4">
        <location>
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            <end position="361"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5471740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="471" mass="50869" checksum="DED16CFB4DF4DFB5" modified="2021-09-29" version="1">MSADWARVRQAVESEWDSTIVSAISAYIEVPNQSPQFDPEWATNGLQEKAFGILIDWMKAQGVQGLTYEYLTAEGRTPFLLVEIAGTVPTKNTVLMYGHMDKQPPLRPWAEGLDPHKAVVLQDKLYGRGGADDGYALFGAITAVSSLQRNGISHGRIVVAIEAGEESGSPDLDYYMERCKERIGNVDLMVCLDSGSMNYTQLWLTTSLRGIAIGELTVQTLTESMHSGVAGGVVPDTFRIVRILLDRIENCKTGEVTIPEAHCEIPLSASKAAEAMMAVPIKEQFSMAPGVSTVPGDNVELSIQNFWKPSLTVTGANLPDPQNAGNVIRTHTTVKLSMRLPPLVKAEAALQAMKRILEADPPYGAKVTFKCVSAGNGCAAPELKPWLHNALHEGSIDAFGNTYACQGMGGAIPFIGMLIDMYPSAQFVVTGLLGPQSNAHGPNEFLHIPYAKGLTFSIARIVAAHFDNTPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KJB9</accession>
    <name>A0A836KJB9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_02098</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061171.1">
        <property type="nucleotide sequence ID" value="XM_067204134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KJB9"/>
    <dbReference type="SMR" id="A0A836KJB9"/>
    <dbReference type="GeneID" id="92358068"/>
    <dbReference type="KEGG" id="loi:92358068"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096:SF52">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="34"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="206"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="370"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="458"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="237"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="397"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="467"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="487"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5472775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="750" mass="80065" checksum="BED9962D1B46EB80" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KK32</accession>
    <name>A0A836KK32_9TRYP</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_04403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062597.1">
        <property type="nucleotide sequence ID" value="XM_067206388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KK32"/>
    <dbReference type="GeneID" id="92360322"/>
    <dbReference type="KEGG" id="loi:92360322"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5477186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="407" mass="43819" checksum="96F5A6B12DD0A538" modified="2021-09-29" version="1">MPIRRAALTATEVALAREACEPLLSSVTHRLLRGGFAGYVEFRQAYAKECERAVASSSTEDRQRPPPRPRREDAASAAAAGPTGFSWSSSAPAQRTPPRQINPEGLKVVLAQSGVLLTPDNYAAILLAYSDPVSSVLADDLLAELHPCRQAPPALAQFVSEVVSSTFFAALPQPCAAVTIDSARDALSALFLAELSSEEASVADAQAAEAQLSALAVAQADVQATFTPVVYAGAAAVPCDDVTTFIVLILQQHPCLEAVLPARCKSVAADLELVPSPPLCGGSVTSREVTSTTSGIDGTALFSIRHKGSTAQRKFERYEADKDRRDEWIRGREEADARPMYMRHAAGYGGHLPEFQYHFGRTFHVIEEDLPQLTKSKPPLEPVPADWYGPGVVLKDSRMNAHHYRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KK39</accession>
    <name>A0A836KK39_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_03594</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061528.1">
        <property type="nucleotide sequence ID" value="XM_067205591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KK39"/>
    <dbReference type="GeneID" id="92359525"/>
    <dbReference type="KEGG" id="loi:92359525"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="99"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="198"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="349"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="409"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="454"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="370"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="413"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="462"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5473525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="797" mass="85691" checksum="D44AB2E3E850E17E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KKD6</accession>
    <name>A0A836KKD6_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5468923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059900.1">
        <property type="nucleotide sequence ID" value="XM_067204348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KKD6"/>
    <dbReference type="SMR" id="A0A836KKD6"/>
    <dbReference type="GeneID" id="92358282"/>
    <dbReference type="KEGG" id="loi:92358282"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5468923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="174" mass="19959" checksum="497B01684AC143B4" modified="2021-09-29" version="1">MRRTSACLGGFTMKYKRGTGLWDEDHVNDFNADKYLSARSTMRWYYGMERLQTRNNINARRATQSYNNNMGLHHSGRGAFERELERRGIQVEKYPLTTTTGAARVAEMVLLRRQELEAQAKTAMESQREARRRDAPSGWYDEADGPLNPRFLASMQSNYTQVITDLPSTPITGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KN38</accession>
    <name>A0A836KN38_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Translocon-associated protein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_01771</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">LSCM4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000022">
        <property type="protein sequence ID" value="KAG5479182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063275.1">
        <property type="nucleotide sequence ID" value="XM_067203816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KN38"/>
    <dbReference type="SMR" id="A0A836KN38"/>
    <dbReference type="GeneID" id="92357750"/>
    <dbReference type="KEGG" id="loi:92357750"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005595">
        <property type="entry name" value="TRAP_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12924:SF0">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12924">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN, ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03896">
        <property type="entry name" value="TRAP_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032356400" description="Translocon-associated protein subunit alpha" evidence="9">
        <location>
            <begin position="25"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5479182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="31211" checksum="694B31D78B1CF923" modified="2021-09-29" version="1">MLRALHKLLLLAFVALLIASVVLAELVPEDEENVAGFSGDEVDEMYVESDAASNSARYVSRVLFLNVTSQSFPSFHAGSKANTVIAFQNNGNEAPQVVFLVVGLLQPPHQYHTVIQNFSVVRQARNVAKLETVSMHYTFTLDPRLEPGEYNMVLGLYVQDSATNQTYFMTAFNSTIMLQEPLGTDPRTVLTYFTLLAIFGCIAYVVGNKLGLVKLIKTMMRSKVSSTRNGTGARHVEMGTGGSSYDPAYINAEHQRYRDELLRQKSSTPHSRHASASPKKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="10" type="ORF">LSCM4_07006</name>
    </gene>
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        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Metakinetoplastina</taxon>
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            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
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    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <text evidence="6">Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505:SF79">
        <property type="entry name" value="PROTEIN SPINSTER"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SPINSTER"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MFS"/>
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    </dbReference>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="538" mass="56897" checksum="0BBC15834550BF53" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KPP5</accession>
    <name>A0A836KPP5_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">LSCM4_06477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Leishmania</taxon>
        </lineage>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG5480907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067208396.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="loi:92362330"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="458"/>
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    </feature>
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        <location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="1318"/>
            <end position="1332"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="EMBL" id="KAG5480907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="10">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Trypanosomatida</taxon>
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    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
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            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <dbReference type="EMBL" id="KAG5483007.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836KRM8_9TRYP</name>
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        <recommendedName>
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    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000015">
        <property type="protein sequence ID" value="KAG5483067.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067209180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KRM8"/>
    <dbReference type="GeneID" id="92363114"/>
    <dbReference type="KEGG" id="loi:92363114"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5483067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="116" mass="13154" checksum="44F215B9535AF515" modified="2021-09-29" version="1">MTVFWLEQWWKRKDHRKIRGARGARFASLRFHGVFIFGVVALVEYVFRSTDNFTARRSAAPPVPAPPPLPTSLGYSMTREMPHLKSIELEREAPAHLPRSGSLDLKGLRGEGRRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KSV2</accession>
    <name>A0A836KSV2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">40S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LSCM4_07953</name>
        <name evidence="14" type="ORF">LSCM4_07954</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">LSCM4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic ribosomal protein eS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000013">
        <property type="protein sequence ID" value="KAG5484386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFHLR010000013">
        <property type="protein sequence ID" value="KAG5484387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064879.1">
        <property type="nucleotide sequence ID" value="XM_067209829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KSV2"/>
    <dbReference type="SMR" id="A0A836KSV2"/>
    <dbReference type="GeneID" id="92363763"/>
    <dbReference type="KEGG" id="loi:92363763"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06087">
        <property type="entry name" value="KOW_RPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000041">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00485">
        <property type="entry name" value="Ribosomal_eS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000876">
        <property type="entry name" value="Ribosomal_eS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032277">
        <property type="entry name" value="Ribosomal_eS4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013845">
        <property type="entry name" value="Ribosomal_eS4_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038237">
        <property type="entry name" value="Ribosomal_eS4_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041982">
        <property type="entry name" value="Ribosomal_eS4_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013843">
        <property type="entry name" value="Ribosomal_eS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16121">
        <property type="entry name" value="40S_S4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00900">
        <property type="entry name" value="Ribosomal_S4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08071">
        <property type="entry name" value="RS4NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002116">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein eS4 N-terminal" evidence="11">
        <location>
            <begin position="3"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding S4" evidence="10">
        <location>
            <begin position="41"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Small ribosomal subunit protein eS4 central region" evidence="9">
        <location>
            <begin position="92"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="8">
        <location>
            <begin position="175"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Small ribosomal subunit protein eS4 C-terminal" evidence="12">
        <location>
            <begin position="209"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG5484386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG5484387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="273" mass="30687" checksum="B005A041D13ED7CE" modified="2021-09-29" version="1">MAKKHLKRLYAPKDWMLSKLTGVFAPRPRPGPHKLRECLPLLVIIRNRLKYALNAREGEMILRQGLVHVDNQPRRDGKYPAGFMDVVEIPKTGDRFRLLYDVKGRFAFVNVSEAEAQIKLMKVVNLYTATGRVPVAVTHDGHRIRYPDPHASIGDTIVYNIREKKCVDVIKNRQGKAVIVTGGANRGRIGEIVKVERHPGAFNIAHLKDASGAEFATRTANVFVIGKDLSNLQVTVPKQQGLRMNVIQEREERLIAAEARKNAPARGARKARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KT24</accession>
    <name>A0A836KT24_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">Eukaryotic translation initiation factor 5A</fullName>
            <shortName evidence="11">eIF-5A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LSCM4_04419</name>
        <name evidence="14" type="ORF">LSCM4_04420</name>
        <name evidence="15" type="ORF">LSCM4_04421</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">LSCM4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as a ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the eIF-5A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062612.1">
        <property type="nucleotide sequence ID" value="XM_067206403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KT24"/>
    <dbReference type="SMR" id="A0A836KT24"/>
    <dbReference type="GeneID" id="92360337"/>
    <dbReference type="KEGG" id="loi:92360337"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045901">
        <property type="term" value="P:positive regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045905">
        <property type="term" value="P:positive regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04468">
        <property type="entry name" value="S1_eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000007">
        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000307">
        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001884">
        <property type="entry name" value="IF5A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048670">
        <property type="entry name" value="IF5A-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020189">
        <property type="entry name" value="IF5A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019769">
        <property type="entry name" value="Trans_elong_IF5A_hypusine_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00037">
        <property type="entry name" value="eIF_5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11673">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 5A FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01287">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21485">
        <property type="entry name" value="IF5A-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003025">
        <property type="entry name" value="eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01376">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
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                <person name="Bates M.D."/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5485720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="328" mass="36913" checksum="30021D52D9B0FC4B" modified="2021-09-29" version="1">MGSIASQIAPGKPKECTMVAKRKEFERTKVVQEATYITFKGLDTHDVYNCCVPFRVDGVYYMFGRVERRNEWVNSHVRLFRQTGHDEYTLVEHAMQWQLEDPFLVKIHGEMLFGGVRVTKDQGKVSHYACDFYRGTIDDLHYFTSGPKNMKDIRLVGLADGKIGIFSHHKTSSTCITGFITINSLDELCSQVIDAAKSIDHTLFGDAWGGVNQPYLLSTGKIGCISHHGYLDTDAKGEVLNVYCITSFVYEPSTNKCYDYKILGTKSCFPDYPPKSPKLMDCAFVSGIVMRDDGKCDLYSGVGDTREGRMVVEYPFDGHGTIVDDLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KXF0</accession>
    <name>A0A836KXF0_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_07386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000008">
        <property type="protein sequence ID" value="KAG5486455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067209278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KXF0"/>
    <dbReference type="GeneID" id="92363212"/>
    <dbReference type="KEGG" id="loi:92363212"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5486455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="502" mass="52032" checksum="B7AC40525C5D81AD" modified="2021-09-29" version="1">MPPRSRPLAQRRRRSSGTGVDRIRGSPIAAVSTVCSQAGAAAKRPRAYSLPNGVSTGSDCSGNKRTSGTRSSLATTATPPRLGTPTRARATALPNTHDRETDEDEADTLQRFSNVSGWQHAREMPPPNPAPTPPPSPPCTLADAGEAGQAAHISSSQRGVRDALSMERSPVCKQPVYGSHDTVSPPTPASPSASSPSARTFSAALLSQLLLAEAACAETAAQQHGGDTFGDGSDATAGPCYAPPQPQPSLLAAPLTAAATTEWCRYRHESDTASLPEQRQEATLSVAASQSLLPMEYLTVCIGVVPLPGSEATFESTAGLKASRLWPWSRTPSTVKSDAAAGVVSEAASGEANHNANGRGSGTEVRWLAPLRDQTVSVHQLLPRRFDTSRQQHTDATVSGRFTSATSIQRSGARVTELANNGTPIGYTFHSGPVAGLIGWTGVFADVPLVLPGAQLAGRLDEVGVAINASREAHARGGVVNGCLQSEPLVCSAAASISILLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FZZ1</accession>
    <name>A0A836FZZ1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_00528</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058707.1">
        <property type="nucleotide sequence ID" value="XM_067202606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836FZZ1"/>
    <dbReference type="SMR" id="A0A836FZZ1"/>
    <dbReference type="GeneID" id="92356540"/>
    <dbReference type="KEGG" id="loi:92356540"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008093">
        <property type="term" value="F:cytoskeletal anchor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051764">
        <property type="term" value="P:actin crosslink formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46756:SF18">
        <property type="entry name" value="GAS2-LIKE PROTEIN PICKLED EGGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46756">
        <property type="entry name" value="TRANSGELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="2">
        <location>
            <begin position="194"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="507"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5465076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="696" mass="76229" checksum="CBADBE4C22C6000E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G205</accession>
    <name>A0A836G205_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-CH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_03616</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061550.1">
        <property type="nucleotide sequence ID" value="XM_067205613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G205"/>
    <dbReference type="GeneID" id="92359547"/>
    <dbReference type="KEGG" id="loi:92359547"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16495">
        <property type="entry name" value="RING_CH-C4HC3_MARCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20893">
        <property type="entry name" value="LD08641P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20893:SF2">
        <property type="entry name" value="LD08641P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="519"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="549"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="628"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="946"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1051"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1084"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1107"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="6">
        <location>
            <begin position="69"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="300"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="381"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1162"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="312"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1170"/>
            <end position="1182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5473547.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1220" mass="135183" checksum="261C45340DA4E051" modified="2021-09-29" version="1"> </sequence>
</entry>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <end position="583"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="EMBL" id="KAG5466561.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="720" mass="80931" checksum="E642740243113AE5" modified="2021-09-29" version="1"> </sequence>
</entry>
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    <name>A0A836G4H3_9TRYP</name>
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            <fullName evidence="3">Uncharacterized protein</fullName>
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        <name type="scientific">Leishmania orientalis</name>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <location>
            <begin position="226"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="136"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5467821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="323" mass="36656" checksum="37590B777C9A3FB0" modified="2021-09-29" version="1">MSSMFRAHRPAGPGRAYWSEPSSLSASSRRAAKPEEQPKRCRSPCEDEVAVKTLLARKRDLQSRVRQQIEVLSGLESNALDFYYTHTIRFEPLLESAWHTAAAVPATGGDGVWEGLAELFPELKTTTTLTGASRESISSPTQDSTPSQPLAVPAKTRYYYDSALMRLYREVAFQEKGLAHKYSSEKARVEAAELSVQRDIIDGSLAKQLETEQEEQESLRKLIDSRNEVMAQCAAHEQSVQAAEERMKEIERAREACLARKTVLEARKQEQMNNAERIKEEVSGFRQSVEAAARELEKRRLINRSLEDEISRRRAAMKRRKKE</sequence>
</entry>
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    <accession>A0A836G6B6</accession>
    <name>A0A836G6B6_9TRYP</name>
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        </alternativeName>
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        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Trypanosomatida</taxon>
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            <taxon>Leishmania</taxon>
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    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 3-(3-amino-3-carboxypropyl)uridine (acp3U) at position 20 in the D-loop of several cytoplasmic tRNAs (acp3U(20)).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a uridine in tRNA + S-adenosyl-L-methionine = a 3-[(3S)-3-amino-3-carboxypropyl]uridine in tRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:62432"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:16092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:82930"/>
            <dbReference type="EC" id="2.5.1.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TDD superfamily. DTWD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.25" evidence="2"/>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059099.1">
        <property type="nucleotide sequence ID" value="XM_067203408.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="92357342"/>
    <dbReference type="KEGG" id="loi:92357342"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:tRNA-uridine aminocarboxypropyltransferase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005636">
        <property type="entry name" value="DTW"/>
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    <dbReference type="InterPro" id="IPR051521">
        <property type="entry name" value="tRNA_Mod/Golgi_Maint"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15627">
        <property type="entry name" value="NATURAL KILLER CELL-SPECIFIC ANTIGEN KLIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15627:SF8">
        <property type="entry name" value="TRNA-URIDINE AMINOCARBOXYPROPYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03942">
        <property type="entry name" value="DTW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01144">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
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        <location>
            <begin position="51"/>
            <end position="231"/>
        </location>
    </feature>
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            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="12">
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    <feature type="compositionally biased region" description="Polar residues" evidence="12">
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            <end position="324"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="331" mass="37995" checksum="DFA2BB58F306736D" modified="2021-09-29" version="1">MKRPRTGYTDTNNERAEKVHAFIKSLHFSVPLYRLREQQVRRECPQCHKRRLYYCYDCLTTVHPESHPPPLALPLNVYVILHPNELRGKSTSLAASTISPDLHIVEYPAVPEELEPESTLVLYPSEQSVELHEVRHLDQYKNVVFIDSTWQQSKAIARDERVKKLKHVRIKSQTSLFWRFQNNDPTYLATVEAIYYFLREYITQVNQVKAEAEHSGSSPSPPLAHQIETKDSKASASASNEVSLNTTDGAASSDDASTFYHGEVDDLLYYYINQYIGVQQRYTNGNLNKYTNRHFSGYIIQNTSWDELVTPPPIDNSTNETTTEAPRKASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G6T0</accession>
    <name>A0A836G6T0_9TRYP</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name evidence="1" type="ORF">LSCM4_01630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059369.1">
        <property type="nucleotide sequence ID" value="XM_067203678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G6T0"/>
    <dbReference type="SMR" id="A0A836G6T0"/>
    <dbReference type="GeneID" id="92357612"/>
    <dbReference type="KEGG" id="loi:92357612"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5466479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="169" mass="19402" checksum="7FD78CB88DE581C3" modified="2021-09-29" version="1">MDHIAVSVSSLVNRIEELRLPVVPYSMYIKSVCIGIPLAVLAHDTAEHWLPTKFRIPVLSWFVRRWRQDPETKRVHLRVIRNLILFAFFVVLRMDGAANEEAEPSDYVSQRLTSASGQRAVNQEIYKSRRAAFNAATAVLGEEEMNMEGVQQQRDAVLRRRHLHDPNVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G8L2</accession>
    <name>A0A836G8L2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FCP1 homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_04561</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">LSCM4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Probable phosphatase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CTDSPL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062753.1">
        <property type="nucleotide sequence ID" value="XM_067206544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G8L2"/>
    <dbReference type="SMR" id="A0A836G8L2"/>
    <dbReference type="GeneID" id="92360478"/>
    <dbReference type="KEGG" id="loi:92360478"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000015">
        <property type="entry name" value="CTD small phosphatase-like protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="176"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="85"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5477342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="365" mass="39574" checksum="B966843A09E6F406" modified="2021-09-29" version="1">MDGERETNATPTSLFRGISNKLESKQQRQPSSSGRLTAASGHGIKAMPANHYRGSGGAGGATPPSSVTTTPTFTVAPVSTLITQVSQHAPPSGQHQRSCGGRAGGSSDASGTDSSGNAHTGPRVASTTAGGSASSRQRVHATELVERARYIRNQPKNTSPIDASAHPSLLPEPLPTVRHKKCLILDVDETLVHSSYQNTGLYDVHLPITLDRDTHVNVYVAFRPHLHRFLEAVAPLFEVVIFTASLSTYCDPLMDSIDKQRILGGLRLFREHCSVVGTTYVKDLSLLGRNLEQVAIIDNSPIAYLFQQRNAIPITSWFDDPRDEELLRLIPVLEALAEADTVYDVLDNYNALLQLQQLHENSGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G9I4</accession>
    <name>A0A836G9I4_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059781.1">
        <property type="nucleotide sequence ID" value="XM_067203131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G9I4"/>
    <dbReference type="GeneID" id="92357065"/>
    <dbReference type="KEGG" id="loi:92357065"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="668"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="400"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="670"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5467979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="705" mass="78481" checksum="235D7B2E8B9967F4" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GD20</accession>
    <name>A0A836GD20_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial glycoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_00420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058603.1">
        <property type="nucleotide sequence ID" value="XM_067202502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GD20"/>
    <dbReference type="GeneID" id="92356436"/>
    <dbReference type="KEGG" id="loi:92356436"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.280.10:FF:000015">
        <property type="entry name" value="Hypothetical_protein_-_conserved"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.280.10">
        <property type="entry name" value="Mitochondrial glycoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003428">
        <property type="entry name" value="MAM33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036561">
        <property type="entry name" value="MAM33_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02330">
        <property type="entry name" value="MAM33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54529">
        <property type="entry name" value="Mitochondrial glycoprotein MAM33-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5464972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="395" mass="43674" checksum="5EFEFF038B512782" modified="2021-09-29" version="1">MWCLKTVTRGPSFARSSTAVAGLLRRCRAAPVASAPGSPTVITYDRRALSTEELVSEETQWGRAMAGKYGSGNYQLFRALYKDLCDEIRREYYTKPPPPLPDTRTTRASPSMGASEAACGVNEGAEQDIKSASSGSARQSSGASDATATTSPTEAEGLPAGSEREDGTDEAANAALQTARPPPPLHTDLICGDGSWSVQHRPEDNIVVFHRDAVKAGRLAAVHAWGRIELKDPPRLNAVLTFADWIPIEVCVERNDIIIHFSMASNEGGMHMRNVRVYAPKSAEERAALLDPSDDGAYARKSFYYDGPCLWHLEQDMLNELYDVMQDHGVTLDWIRWAASWVFYLEHVHYVRWNLGMLEELIPSSVRGPEEDFLLPEEKALLEEPVEDWLSAHSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GDP9</accession>
    <name>A0A836GDP9_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060510.1">
        <property type="nucleotide sequence ID" value="XM_067204958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GDP9"/>
    <dbReference type="GeneID" id="92358892"/>
    <dbReference type="KEGG" id="loi:92358892"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="614"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="799"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="229"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="339"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="396"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="499"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="553"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="851"/>
            <end position="861"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5470244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="861" mass="89826" checksum="E8A2A3693651EBD7" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GEP7</accession>
    <name>A0A836GEP7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aspartyl aminopeptidase</fullName>
            <ecNumber evidence="4">3.4.11.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_03681</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate.</text>
            <dbReference type="EC" id="3.4.11.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the peptidase M18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.21" evidence="4"/>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061614.1">
        <property type="nucleotide sequence ID" value="XM_067205677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GEP7"/>
    <dbReference type="SMR" id="A0A836GEP7"/>
    <dbReference type="GeneID" id="92359611"/>
    <dbReference type="KEGG" id="loi:92359611"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05658">
        <property type="entry name" value="M18_DAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.250.10:FF:000001">
        <property type="entry name" value="Aspartyl aminopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.250.10">
        <property type="entry name" value="Aminopeptidase i, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001948">
        <property type="entry name" value="Peptidase_M18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023358">
        <property type="entry name" value="Peptidase_M18_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002759">
        <property type="entry name" value="PRK02813.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570:SF3">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02127">
        <property type="entry name" value="Peptidase_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00932">
        <property type="entry name" value="AMINO1PTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101821">
        <property type="entry name" value="Aminopeptidase/glucanase lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 11" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5473611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="453" mass="49512" checksum="1108C0782DE3843F" modified="2021-09-29" version="1">MSTIVSDHVVKIAQDFVSFINKAITPFQAVQTVTEILKDAGYTQLDEGNTWPEISAGGKYYLTRNGTSIVAFSVGGKYNPADGVKIVGAHTDSPNFLLKPRTRSTSADYQRVAVQCYGGGLWHSWFDRDLTVAGRVVISRDRLEQKLVKIDKPIMRIPNLAIHLTSGKDREAFSPNKESHLVPIICTQLAAKIAECDDKDAANSNHCISLMKALARVAECSPEEIVDFDLSVVDTQPAVIGGIHDEFIFASRLDNLISCYCAVRALVEAELLENDSMVRMVCLFDHEECGSSSSQGAAGSLVPDVIEHIVSSKTLRATLVANSFLLSVDGAHGCHPNYVEKHESAHRPALHKGPVIKYNANVRYATNGLTAAVVKDIAKKADVPIQEFVVRNDSPCGSTIGPILSSLSGIKTADIGNPMISMHSIREMCGTLDIYYLKRLIESFFVNYKNLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GFC4</accession>
    <name>A0A836GFC4_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059332.1">
        <property type="nucleotide sequence ID" value="XM_067203641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GFC4"/>
    <dbReference type="GeneID" id="92357575"/>
    <dbReference type="KEGG" id="loi:92357575"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="784"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5466442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="804" mass="90302" checksum="C70901CFB917F62F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GGL0</accession>
    <name>A0A836GGL0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_03835</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FUN14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061767.1">
        <property type="nucleotide sequence ID" value="XM_067205830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GGL0"/>
    <dbReference type="GeneID" id="92359764"/>
    <dbReference type="KEGG" id="loi:92359764"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007014">
        <property type="entry name" value="FUN14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04930">
        <property type="entry name" value="FUN14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5474661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="251" mass="27803" checksum="3873A4DFA92CF0C4" modified="2021-09-29" version="1">MPPSGKSDAVAVCRDEDNLLNTDDLKHVLDIVVNLGHPPSSKGANGICRLFEVPFHCKRVLWDEWLADWQSGAFREFTESESFRQVRGLLVRALDMDGDGKITPKDLQLMYDTRLTPALTRNQDTLNKWLPFAGQCAFGFVVGLGVGTVARSAYQRKWWIAGIGFAVYTGVQYLAQQNYVNRKLLEEAFRGKVRQLADVNGDGEINREDINALVENRMRFISTKLGPGGLAPGVAGYASLALGFARGIRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GHJ1</accession>
    <name>A0A836GHJ1_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_00826</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059549.1">
        <property type="nucleotide sequence ID" value="XM_067202899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GHJ1"/>
    <dbReference type="SMR" id="A0A836GHJ1"/>
    <dbReference type="GeneID" id="92356833"/>
    <dbReference type="KEGG" id="loi:92356833"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="476"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="696"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="878"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="246"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="497"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="704"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="880"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="891"/>
            <end position="906"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5467747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1000" mass="111988" checksum="5C5B923DF025381A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GHY0</accession>
    <name>A0A836GHY0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Orotidine 5'-phosphate decarboxylase</fullName>
            <ecNumber evidence="4">2.4.2.10</ecNumber>
            <ecNumber evidence="5">4.1.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">OMP decarboxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LSCM4_05590</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>orotidine 5'-phosphate + H(+) = UMP + CO2</text>
            <dbReference type="Rhea" id="RHEA:11596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="4.1.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the OMP decarboxylase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="4"/>
    <dbReference type="EC" id="4.1.1.23" evidence="5"/>
    <dbReference type="EMBL" id="JAFHLR010000016">
        <property type="protein sequence ID" value="KAG5482337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064343.1">
        <property type="nucleotide sequence ID" value="XM_067207529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GHY0"/>
    <dbReference type="SMR" id="A0A836GHY0"/>
    <dbReference type="GeneID" id="92361463"/>
    <dbReference type="KEGG" id="loi:92361463"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04725">
        <property type="entry name" value="OMP_decarboxylase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000183">
        <property type="entry name" value="Orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000058">
        <property type="entry name" value="Orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018089">
        <property type="entry name" value="OMPdecase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011995">
        <property type="entry name" value="OMPdecase_type-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004467">
        <property type="entry name" value="Or_phspho_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00336">
        <property type="entry name" value="pyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02127">
        <property type="entry name" value="pyrF_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43375">
        <property type="entry name" value="OROTIDINE 5'-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43375:SF1">
        <property type="entry name" value="OROTIDINE 5'-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00156">
        <property type="entry name" value="OMPDECASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Orotidine 5'-phosphate decarboxylase" evidence="15">
        <location>
            <begin position="15"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG5482337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="457" mass="49550" checksum="CB23BF17E6E5FD5D" modified="2021-09-29" version="1">MSFFDLLNERARRSLLCVGLDPRAKTAAAAVEECKRLIEQTHEYAAAYKPNAAFFELFGAEGWAALSEVIGAVPAGIPVVLDAKRGDIADTADAYATSAFQHLNAHAITASPYMGADSLQSFMRYADKGVFVLCKTSNKGSNDLQCLRVGDKYLYEAVAERAEGPWNANRNVGLVVGATDPVALARVRARAPTLWFLVPGIGAQGGSLKASLDAGLRADGSGMLINVSRGLARAADPRAAAKELCEEINTIRFAKGASAELAKALVDSHCVRFGSFTLKSGKTSPIYIDLRRLVTYPSIMRLVAREYAKVLRRYTFDRIAGLPYAALPIASAISNEMNVPLIYPRREAKSYGTKAAIEGDYKKGDRVVIIDDLVSTGETKVEAVEKLKSAGLEVVSIVVLVDREMGAKAFLNKLGYDFESVVGLYQLLPLWRQGNAITSQQEADVRAFLGQWRQSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GI18</accession>
    <name>A0A836GI18_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_01135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5468047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059849.1">
        <property type="nucleotide sequence ID" value="XM_067203199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GI18"/>
    <dbReference type="GeneID" id="92357133"/>
    <dbReference type="KEGG" id="loi:92357133"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37935">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_14, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37935:SF1">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_14, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5468047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="332" mass="36664" checksum="09070A5B6023665D" modified="2021-09-29" version="1">MMHRSRSATFLRRLQGSCILPGSLHRVLAPQLHPLIASTRHGCIRSTRVRRALSHRRRLASLYSDATPMATAGRMCSVKSPSEPPSRPHPDFPTLSRTVAATAPEKVAPSTTAAERVTNATSRSASDTPSQLQSPSPLLQDSLVRRLLASWQQGVVASIGAVMGIGFLVYFLYIPVKEDTVHHTAVVASEALADARLKGQAVQLSKDVVVEVLRNPKSLDATVDVVVELLAREETKIAVSSLLQSLFEDHYTQEVTKKFVLRVVQDPWIQDQLQVITEEQVRKLLNNAAVKSELSKFLLMSALDSLEKPQLHYEVARAIRLSAASLLNFWWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GJ06</accession>
    <name>A0A836GJ06_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UDENN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_01483</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059225.1">
        <property type="nucleotide sequence ID" value="XM_067203534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GJ06"/>
    <dbReference type="SMR" id="A0A836GJ06"/>
    <dbReference type="GeneID" id="92357468"/>
    <dbReference type="KEGG" id="loi:92357468"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901981">
        <property type="term" value="F:phosphatidylinositol phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040032">
        <property type="entry name" value="DENND1A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13196">
        <property type="entry name" value="DENN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13196:SF14">
        <property type="entry name" value="UDENN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="2">
        <location>
            <begin position="47"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5466335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="558" mass="62491" checksum="62348EC66690CDD6" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GKU8</accession>
    <name>A0A836GKU8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S acidic ribosomal protein P0</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_04216</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 7">Ribosomal protein P0 is the functional equivalent of E.coli protein L10.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">P0 forms a pentameric complex by interaction with dimers of P1 and P2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062142.1">
        <property type="nucleotide sequence ID" value="XM_067206205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GKU8"/>
    <dbReference type="SMR" id="A0A836GKU8"/>
    <dbReference type="GeneID" id="92360139"/>
    <dbReference type="KEGG" id="loi:92360139"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05795">
        <property type="entry name" value="Ribosomal_P0_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.20:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1730:FF:000005">
        <property type="entry name" value="Ribosome assembly factor mrt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050323">
        <property type="entry name" value="Ribosomal_protein_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030670">
        <property type="entry name" value="uL10_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039087">
        <property type="entry name" value="L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="9">
        <location>
            <begin position="118"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="284"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR039087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5475634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="324" mass="34737" checksum="8BEBEC7AE4520481" modified="2021-09-29" version="1">MPSITTAKREYEEHLVDCLTKYSCVLFVGMDNVRSQQVHDVRRALRGKAEFVMGKKTLQAKIVEKRAQAKDASPDAKLFNDQCEEHNLLSGNTGLIFTNNAVQDIKAVLDAHRVKAPARVGAIAPCDVVVPAGSTGMEPTQTSFFQALNIATKIAKGMVEIVTEKKVLSTGDKVDNSTATLLQKLNISPFYYQVDVLSVWDRGVLFTREDLNMTEDMVEKMLMEGLGNVAALSLGAGIPTSATIGPMLVDAFKNLLAVSVATSYEFEEHNGKFLREAAISGSLAGSGPAAAESAAAAPEASSAAAKKEEPEESDEEDFGMGGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GLS4</accession>
    <name>A0A836GLS4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059048.1">
        <property type="nucleotide sequence ID" value="XM_067203357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GLS4"/>
    <dbReference type="SMR" id="A0A836GLS4"/>
    <dbReference type="GeneID" id="92357291"/>
    <dbReference type="KEGG" id="loi:92357291"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032870">
        <property type="entry name" value="ALKBH7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21052:SF1">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21052">
        <property type="entry name" value="SPERMATOGENESIS ASSOCIATED 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="1">
        <location>
            <begin position="99"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5466158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="318" mass="36420" checksum="B1999CB8A59E5BC9" modified="2021-09-29" version="1">MSLTSRFMGGVKHLLKGGSLKYLAAGEPYCPFGEEFGLTILPEYILEDDAANLRKGYVDVYTRASDRIVLSDGRFQLPPLPHGSFTPLLDRLEQDNIVPKNWLNNQTANLYEPGDFIRAHIDNLFVYDDIFAVCSLGSNCLLRFVHVQNGEELDVMVPDRSVYIMSGPARYVYFHMVLPVEAQRFSLVFRRSIMESDGGFRPVSTPLKEIMPYRATQILNALYSKQVGGVRVSVDDDFLESADIGAFDTSRWVKRLHPLRDWSLLQQLEEDEARIEEMREKRFIDVDFSWRYKELRPYYKAMEASLVSSHATHATSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GLT9</accession>
    <name>A0A836GLT9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase RBP11-like dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_03966</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061895.1">
        <property type="nucleotide sequence ID" value="XM_067205958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GLT9"/>
    <dbReference type="SMR" id="A0A836GLT9"/>
    <dbReference type="GeneID" id="92359892"/>
    <dbReference type="KEGG" id="loi:92359892"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07029">
        <property type="entry name" value="RNAP_I_III_AC19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.10:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00261">
        <property type="entry name" value="RNApol_arch_Rpo11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008193">
        <property type="entry name" value="RNA_pol_Rpb11_13-16kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033898">
        <property type="entry name" value="RNAP_AC19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022905">
        <property type="entry name" value="Rpo11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I,II,III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946:SF28">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01154">
        <property type="entry name" value="RNA_POL_L_13KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RBP11-like dimerisation" evidence="6">
        <location>
            <begin position="48"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Bates M.D."/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1059" mass="116246" checksum="40D04A143B07B279" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">LSCM4_02869</name>
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        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Leishmania</taxon>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG5470175.1"/>
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        <property type="nucleotide sequence ID" value="XM_067204889.1"/>
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    <dbReference type="KEGG" id="loi:92358823"/>
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            <begin position="49"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="169"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="810"/>
            <end position="822"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5470175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1433" mass="156265" checksum="EC0F41AC0B2FD708" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GT68</accession>
    <name>A0A836GT68_9TRYP</name>
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        <recommendedName>
            <fullName evidence="4">Methyltransferase type 11 domain-containing protein</fullName>
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        <name evidence="5" type="ORF">LSCM4_06455</name>
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        <name type="scientific">Leishmania orientalis</name>
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    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000019">
        <property type="protein sequence ID" value="KAG5480886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063887.1">
        <property type="nucleotide sequence ID" value="XM_067208375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GT68"/>
    <dbReference type="SMR" id="A0A836GT68"/>
    <dbReference type="GeneID" id="92362309"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Malonyl-ACP_OMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13090">
        <property type="entry name" value="ARGININE-HYDROXYLASE NDUFAF5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR13090:SF1">
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        <property type="entry name" value="Methyltransf_11"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5480886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="385" mass="43725" checksum="EB55C5CD7D47A451" modified="2021-09-29" version="1">MPSPIVLTRAAPARSLNIKMFDRKVKGLQRSCVSSPACDIHKLCAEQMLDRRAFVKRDTPIVLEVGAHTGWYLRHMIERKEFHGLKQYIQTDISECRLNRNYEEIKNVIPPDVEFVQICCDEEQPSPFGIPDKSVDMVVSCLSMHWVNDLETSMVNIRKVLKRDGFFLNAMFGGNTLYELRGCFSMAQTEALGGVTPYVSPMIDGAGLSTLVLQAGFNIPTIDIDRHLLLYETPFHLMEHLAVMGESACHYMRQPMKRDVLLCACALYDTMYKQNGLVPATFEVFHTIAWSPSPTQAKPLPRGSGQIPLATWNSKNRKQLQSVLDEYALNPDDTVLQSRAEEIFKRLREESAELMAKKGLDSRGFERDRDEEARQLDAKPLPPFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GTJ5</accession>
    <name>A0A836GTJ5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_03149</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
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            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060717.1">
        <property type="nucleotide sequence ID" value="XM_067205165.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92359099"/>
    <dbReference type="KEGG" id="loi:92359099"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="84"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="156"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="394"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="494"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="647"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="976"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1689"/>
            <end position="1732"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1631"/>
            <end position="1662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
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            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="400"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="659"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="678"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1689"/>
            <end position="1701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1704"/>
            <end position="1713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5471600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1890" mass="199158" checksum="834D54C276C8F373" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GTK1</accession>
    <name>A0A836GTK1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nucleoside transporter 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_00197</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058387.1">
        <property type="nucleotide sequence ID" value="XM_067202286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GTK1"/>
    <dbReference type="SMR" id="A0A836GTK1"/>
    <dbReference type="GeneID" id="92356220"/>
    <dbReference type="KEGG" id="loi:92356220"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002259">
        <property type="entry name" value="Eqnu_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332:SF82">
        <property type="entry name" value="TRANSPORTER 2, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01733">
        <property type="entry name" value="Nucleoside_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="346"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="437"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="472"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5464756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="500" mass="54548" checksum="A24FC3613958B95A" modified="2021-09-29" version="1">MTDQSAAAAEGHRPLPWYRMGFHTFAEFNTYLTFVLLGMSIMMVTSAITSAPDFVSKYYIYATGNPDAVAEAPMFWRNANTFYNAGTYAVQVITDVASLTPLVRSIPLGFRLFLGLGIPLVELLLIIIVPAATIPTQGGAIAVIMVVALMGGFSTALRESCTNALVGPFPTKFMNAEQWGLTVIALLMSIIQIILKVSMGSTYQDVLTISRIYFGIGIAIQLLAIVELFLLRYNPFAQKYIAEFRAAALRRRGDMGLERSQESNEPATGDVAEVVSKLENKEGPLYELDETDEVRAVSSAAFAVENANVLQATGDADKMVDLDQTDNITSTEQMLRVSVWSVARRIYPMLLCAFTIFFTSLLLFPGVFFMVPVNSDWYMTIVVTLFNAGDFISRLILMVRMLRPSPKLVIAGTLGRLGVVPLLVLCVRGLIPGAALPYILIFVVGLTNGYFGTMSCIHCPRTPTLHYAGERSLAAMLSGIALMLGLCFGSNLSLAITLTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GTV8</accession>
    <name>A0A836GTV8_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060882.1">
        <property type="nucleotide sequence ID" value="XM_067205330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GTV8"/>
    <dbReference type="GeneID" id="92359264"/>
    <dbReference type="KEGG" id="loi:92359264"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="280"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5471765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="366" mass="39115" checksum="BA56BB5532F3EAB6" modified="2021-09-29" version="1">MPPPTSGSPRRCQPLRGHESPPPVISDSDSTPKLPPIRHHILDDHSDPPSIRSDTLDVIERSRNDDEVRVAVNNLRRSSSSTRIVFNSLSTLDSNDSLPSLIRSQRTSSSTSANSSLCGSCGKGSTPVVKQADCSTRSIDAAKNSGAYVDHENWMSSSIELEAADARKAITVMKGRKQVRCPTAPSLTAEAEPATEASRVAKMDAHGSRRSLLLSGRKRSVRINTPPESPREAQSQMELRPLQTAVLMQQQEQLPLLPINGSRQLQPQQHPMQCPSMPASSGLSTLLPLPSSPSTPHDMNLRPVTPTVAESPTSGLTLSSTASCQTDPQPLSSTSEESGAVIGAALKKIFSLCSVNTKEVVLKGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GU02</accession>
    <name>A0A836GU02_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">N-acetyltransferase subunit Nat1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_00135</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058326.1">
        <property type="nucleotide sequence ID" value="XM_067202225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GU02"/>
    <dbReference type="SMR" id="A0A836GU02"/>
    <dbReference type="GeneID" id="92356159"/>
    <dbReference type="KEGG" id="loi:92356159"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1040:FF:000009">
        <property type="entry name" value="N-acetyltransferase subunit Nat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1010">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021183">
        <property type="entry name" value="NatA_aux_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767:SF2">
        <property type="entry name" value="N(ALPHA)-ACETYLTRANSFERASE 15_16, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12569">
        <property type="entry name" value="NatA_aux_su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000422">
        <property type="entry name" value="N-terminal-AcTrfase-A_aux_su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="46"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="80"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5464695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="710" mass="81135" checksum="AE2A352AF00BF415" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GU20</accession>
    <name>A0A836GU20_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_03413</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060972.1">
        <property type="nucleotide sequence ID" value="XM_067205420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GU20"/>
    <dbReference type="GeneID" id="92359354"/>
    <dbReference type="KEGG" id="loi:92359354"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5471855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="164" mass="17824" checksum="3FCB0085871D25C5" modified="2021-09-29" version="1">MLAYEVHSIHVGAHVYACVDSEGATLSVSGDREVTLHCAGGLTSHPFPFDKIVFAPFCNILYSCCVADGLRLQFGAALQRPAPSFRDVPRSATVVHGDPAPHVGEAFYEVLLLAAEEVERIAGVHHSQSPYKCVFSVVRMYPWNEEDLLEAAAQTHCRGSRSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GW12</accession>
    <name>A0A836GW12_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000016">
        <property type="protein sequence ID" value="KAG5482341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064347.1">
        <property type="nucleotide sequence ID" value="XM_067207533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GW12"/>
    <dbReference type="GeneID" id="92361467"/>
    <dbReference type="KEGG" id="loi:92361467"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="863"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5482341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1132" mass="117517" checksum="D591AD24EE49450B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GWD7</accession>
    <name>A0A836GWD7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_01462</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059206.1">
        <property type="nucleotide sequence ID" value="XM_067203515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GWD7"/>
    <dbReference type="GeneID" id="92357449"/>
    <dbReference type="KEGG" id="loi:92357449"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17330">
        <property type="entry name" value="MFS_SLC46_TetA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF15">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="331"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="443"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="473"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="503"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="40"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="526"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="628"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="286"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="530"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="544"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="628"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5466316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="698" mass="76098" checksum="CE17DC253249BF7C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GZE7</accession>
    <name>A0A836GZE7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="2 10">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 10">Lysyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_07194</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>tRNA(Lys) + L-lysine + ATP = L-lysyl-tRNA(Lys) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="2 10"/>
    <dbReference type="EMBL" id="JAFHLR010000015">
        <property type="protein sequence ID" value="KAG5482984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064480.1">
        <property type="nucleotide sequence ID" value="XM_067209097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GZE7"/>
    <dbReference type="SMR" id="A0A836GZE7"/>
    <dbReference type="GeneID" id="92363031"/>
    <dbReference type="KEGG" id="loi:92363031"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00775">
        <property type="entry name" value="LysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000629">
        <property type="entry name" value="Lysine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000177">
        <property type="entry name" value="Lysine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00252">
        <property type="entry name" value="Lys_tRNA_synth_class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034762">
        <property type="entry name" value="Lys-tRNA-ligase_II_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001756">
        <property type="entry name" value="PRK00484.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918:SF9">
        <property type="entry name" value="LYSINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918">
        <property type="entry name" value="LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LysRS2"/>
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        <property type="entry name" value="TRNASYNTHLYS"/>
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            <begin position="236"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5482984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="586" mass="67125" checksum="1FE9209182B67AE0" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GZU6</accession>
    <name>A0A836GZU6_9TRYP</name>
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        <recommendedName>
            <fullName evidence="6">Guanine nucleotide-binding protein subunit beta-like protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="4" type="ORF">LSCM4_02020</name>
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        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
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    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067204057.1"/>
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    <dbReference type="KEGG" id="loi:92357991"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    </dbReference>
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        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR050459">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR22850">
        <property type="entry name" value="WD40 REPEAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
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    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="9"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5472698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="84" mass="8706" checksum="38B4465D345F9819" modified="2021-09-29" version="1">MSIGGATIHAAHASGASAAQFHPIGAFLLATASAEGSISLWDIRRLTEPVGDLSFHGRVITGLQWSPFSDTVLLSYGADGRVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">LSCM4_04414</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
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            <taxon>Trypanosomatida</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477197.1"/>
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    </dbReference>
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    <dbReference type="GeneID" id="92360333"/>
    <dbReference type="KEGG" id="loi:92360333"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="29"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5477197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="211" mass="21958" checksum="FD38D44FF198E248" modified="2021-09-29" version="1">MLSPPNLEVAAARLDWEMGQAGVRAAAPCGEHEIDKAGPGGVGAAEHDDGGAEPAPRPHRAAASGRGSTFASEKMALCGAYMRPPTPAGLHLEATQFECSALLWLRQGPKEDSGRADGSRLEAAGGGRPARAFMPRQGTRYITVAATVHALGPATACGICRRSTNKITTAALSQSQSLGIDTAASEQHPSHLPLRLEALAVQLEHQDCLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H0V0</accession>
    <name>A0A836H0V0_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_07618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000012">
        <property type="protein sequence ID" value="KAG5484846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064958.1">
        <property type="nucleotide sequence ID" value="XM_067209498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H0V0"/>
    <dbReference type="GeneID" id="92363432"/>
    <dbReference type="KEGG" id="loi:92363432"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5484846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="66" mass="6895" checksum="8EBB0F9626E51C8C" modified="2021-09-29" version="1">MEAGIATKLANSPPSYQHTAEAKWHQRDADTSAQPIGPAAEPHQQPVACDYAGVAPTEAKRAAING</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H1D5</accession>
    <name>A0A836H1D5_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_02442</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060023.1">
        <property type="nucleotide sequence ID" value="XM_067204471.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="92358405"/>
    <dbReference type="KEGG" id="loi:92358405"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5469046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="268" mass="31477" checksum="70997A4570BC45EB" modified="2021-09-29" version="1">MSLQRAHIRTVIPPRPAVTTLVYLDHFGRAVRTGVETDLSLIRTRDNKFYLQRVLPNGEVVRWLAPGLNYLKNVTNFETYALNDIDENGGVVIPSDVMPTAAHDAPGLRDAVFYMTKLEATSKFTRKDRRRWHRRLFAHWKESPEKYLSHTLGTYGVAFLVMLWVCVRGFHSIKNQKPFWDVNVYGLTDEERERTNPWLRLKRFSERHPEHEGVDMTVTMLSPGQSRLSSARSELRESDFTDPHYHSEFWWKVRHCYYYGHWPKGLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H1I1</accession>
    <name>A0A836H1I1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Developmentally regulated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_07284</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000015">
        <property type="protein sequence ID" value="KAG5483069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064565.1">
        <property type="nucleotide sequence ID" value="XM_067209182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H1I1"/>
    <dbReference type="GeneID" id="92363116"/>
    <dbReference type="KEGG" id="loi:92363116"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5483069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="116" mass="13198" checksum="41F715BC565AF515" modified="2021-09-29" version="1">MTVFWLEQWWKRKDHRKIRGARGARFASLRFHGVFIFGVVALVEYVFRSTDNFTARRSADPPVPAPPPLPTSLGYSMTREMPHLKSIELEREAPAHLPRSGSLDLKGLRGEGRRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H1M1</accession>
    <name>A0A836H1M1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA mismatch repair proteins mutS family domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_03622</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061556.1">
        <property type="nucleotide sequence ID" value="XM_067205619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H1M1"/>
    <dbReference type="GeneID" id="92359553"/>
    <dbReference type="KEGG" id="loi:92359553"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051026">
        <property type="term" value="P:chiasma assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF20">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="6">
        <location>
            <begin position="854"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="91"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="531"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="949"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1000"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="574"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="966"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1008"/>
            <end position="1026"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5473553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1096" mass="117407" checksum="C2649A8ACA72F555" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H1S2</accession>
    <name>A0A836H1S2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SAM-dependent MTase RsmB/NOP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_03698</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061631.1">
        <property type="nucleotide sequence ID" value="XM_067205694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H1S2"/>
    <dbReference type="SMR" id="A0A836H1S2"/>
    <dbReference type="GeneID" id="92359628"/>
    <dbReference type="KEGG" id="loi:92359628"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
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        <property type="entry name" value="NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
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    <dbReference type="PANTHER" id="PTHR22808:SF27">
        <property type="entry name" value="SAM-DEPENDENT MTASE RSMB_NOP-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
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        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
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    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="7">
        <location>
            <begin position="51"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="611"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="611"/>
            <end position="625"/>
        </location>
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    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="287"/>
        </location>
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    <feature type="binding site" evidence="5">
        <location>
            <begin position="158"/>
            <end position="164"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5473628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="632" mass="69064" checksum="954B387CB64F5BA0" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H3C5</accession>
    <name>A0A836H3C5_9TRYP</name>
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        <recommendedName>
            <fullName evidence="2">WLM domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="3" type="ORF">LSCM4_02805</name>
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    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
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            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060377.1">
        <property type="nucleotide sequence ID" value="XM_067204825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H3C5"/>
    <dbReference type="SMR" id="A0A836H3C5"/>
    <dbReference type="GeneID" id="92358759"/>
    <dbReference type="KEGG" id="loi:92358759"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:metallopeptidase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013536">
        <property type="entry name" value="WLM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053000">
        <property type="entry name" value="WSS1-like_metalloprotease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46622">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46622:SF1">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08325">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51397">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5470111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="413" mass="44488" checksum="C355CBDBFA390812" modified="2021-09-29" version="1">MSSTFMAQLPYIGSSATLGWQHDDVALSYMEHILQRARVLLPRRGWRVGLIKEFYPRGASLLGLNVNAGSEVCIRFRIPGKKNEFLPFHEVLCTALHEFTHCAHARHDRSFWNLYYDLVKECEALEVTMIQQGMQIYPELSGSPVGSSATAPQQSRSARQGGAAMTPSSSRRGGRRWGAGGAVGGVRGRNGGISARGDNTTQSMIKVGLTPSSCSPSSAKGEAFPGVGRRLGGVGDRQHSGVAAFTPTRDALRRILADAAERRLMRKPPPTATAHLGSETLTRPLDDGTHSRGEESQAEVDDEGVPDCVPQGLSDEQDGGGWRCLRCGFLNDHDVIGSCAFCADCDDGDETEAALLKRPRLDGDHPSLGMSTRIGSSSTAPDTVPAQPSALQQCESRSNEKYIILSDDDDDGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H4C4</accession>
    <name>A0A836H4C4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VPS9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_04594</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067206577.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="92360511"/>
    <dbReference type="KEGG" id="loi:92360511"/>
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        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
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        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23084:SF262">
        <property type="entry name" value="FYVE-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23084">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="VPS9" evidence="2">
        <location>
            <begin position="480"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5477375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="837" mass="92778" checksum="B4B257473643EAC6" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H5Z2</accession>
    <name>A0A836H5Z2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">D-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="9">1.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_04282</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.4" evidence="9"/>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062206.1">
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        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
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    </dbReference>
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        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
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        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
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        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
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        <property type="entry name" value="Oxid_FAD_bind_N"/>
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        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
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        <property type="entry name" value="D-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="D-LACTATE DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
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    </dbReference>
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        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
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    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
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        <location>
            <begin position="58"/>
            <end position="234"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="493" mass="54025" checksum="6E9D732E1198F6C0" modified="2021-09-29" version="1">MTRPGNQAEYSVGTFKERQAKYAGCLAQLNRVLKSPQKQLVLRENQLRLYSKDASHHMHVLPVAAVIPSSVEEVAAVVKVCVAHKVPMTPRGAGTGVEGGVIPYAGGIVIDTVGLLRMDFDIDNACVWVGAGVKKLALNHAASERGFLFGPDPASDPSVGGMVSTSGSGMSTLRYGTTRENVISLRVVTPCGDVVQTRQVVRKSSSGLELTQLYIGSEGTLGIVCEVCFRLFPETKYSAGGYAAFESTGDAVRAVVALRQRGVPQTLLRCELMNKDIVEATNRYGKMSLPETATVLLEFTGNDWWMSDIKRDYRHVARIFREVGKAKTVRYLRPGKEMDDVWTARRSCYFAAMCCRGKKEKVFATDVCVPISKLTEMVEYTEKEFAKANRKCLICAHISDGNYHASIPFSSTQEMAELRALETKMIKRAIELGGTISGEHGIGVGKVHLVTDEHGQSHIDVQEAIKAALDKDNLMNPGTFYPVQQRLYPTAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H723</accession>
    <name>A0A836H723_9TRYP</name>
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        <recommendedName>
            <fullName evidence="4">Ribosomal protein L7Ae/L30e/S12e/Gadd45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471595.1"/>
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    </dbReference>
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        <property type="entry name" value="GH01354P"/>
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            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="242"/>
        </location>
    </feature>
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        <location>
            <begin position="421"/>
            <end position="453"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="442"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5471595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="562" mass="61816" checksum="23B26F0F3428D05F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H7N0</accession>
    <name>A0A836H7N0_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_07809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000006">
        <property type="protein sequence ID" value="KAG5487319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065816.1">
        <property type="nucleotide sequence ID" value="XM_067209686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H7N0"/>
    <dbReference type="GeneID" id="92363620"/>
    <dbReference type="KEGG" id="loi:92363620"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="563"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="406"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5487319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="767" mass="82948" checksum="75052F938735C0AA" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H7S0</accession>
    <name>A0A836H7S0_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060760.1">
        <property type="nucleotide sequence ID" value="XM_067205208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H7S0"/>
    <dbReference type="GeneID" id="92359142"/>
    <dbReference type="KEGG" id="loi:92359142"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="515"/>
            <end position="536"/>
        </location>
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            <end position="583"/>
        </location>
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            <begin position="112"/>
            <end position="121"/>
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            <end position="758"/>
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        </source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="976" mass="93687" checksum="1D4230541E8DE33C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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        </submittedName>
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        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
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            <taxon>Eukaryota</taxon>
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            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000008">
        <property type="protein sequence ID" value="KAG5486444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="loi:92363201"/>
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        <property type="entry name" value="NET_actin-binding_domain"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN NETWORKED 3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32258">
        <property type="entry name" value="PROTEIN NETWORKED 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="83"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <end position="1043"/>
        </location>
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            <end position="1947"/>
        </location>
    </feature>
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        <location>
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        </location>
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    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="304"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
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            <end position="455"/>
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    <feature type="coiled-coil region" evidence="1">
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            <end position="1136"/>
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            <begin position="1520"/>
            <end position="1592"/>
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            <end position="113"/>
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            <dbReference type="SAM" id="Coils"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
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        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
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                <person name="Gatherer D."/>
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            <strain evidence="10">LSCM4</strain>
        </source>
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        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
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    </dbReference>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5479310.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="362" mass="39618" checksum="63A6B0F28069CAC0" modified="2021-09-29" version="1">MLYRPAVPVPADALVQRNLEFTRAAWKAGIRPDQREANQLRVVEIDFPLLSRDVVQVKCGNTIATATVSCDLVEPSPYRPKHGFFEVHARQLLHERDPLDQSKEIKRIGMYLTRLLCGSVLETEGLCVIPGRRVWSIDAEVIIVNDDGNVQDVAQWAVMAALQHVRRPELTIRGDEVVVHPPHERDPVPLPLHHIPLSFTFAVCANPQEVQLAVRAATLRRAQAPLAGASSGANGGEDDVHEKELAWSSDALQVVVDPGLEEVAAAACTVSVSVNGEGHVCSLEKGDGCDVSIAYLERCMEAAAKLAQALLAQMKESMEAHNAKRREAVRSQFLWAQQRRGIQAVTTVGDDGAHVSKKAKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H8A9</accession>
    <name>A0A836H8A9_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_02211</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061282.1">
        <property type="nucleotide sequence ID" value="XM_067204245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H8A9"/>
    <dbReference type="SMR" id="A0A836H8A9"/>
    <dbReference type="GeneID" id="92358179"/>
    <dbReference type="KEGG" id="loi:92358179"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5472886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="456" mass="51034" checksum="C0F150D44DD90C2B" modified="2021-09-29" version="1">MSIFPGLCGDVAATNYRVFLGTLPNLAIEKRFLRQLQSVFPWYASRKRVKEQASEFLEIDLASCDPELLLRYTHVYYARRQLYDELVDRQLTLIETGKAAKVADSSLLSCLAEVNAAMTPRLQYELLLLQQAKKACRVPWRRELNPDAALDVHDYLCMMRIVEEDATGITDAEMQARAYLPREVLEAKAMELAAMFFDGSSPARTGARATLEKKEKLLQRLIPADYSKVGTVEKLRPVDVTTLYRFAGERVCGQPADKLFARALWGHIFRKVGSHPLYLQRASLYWARHSGLDPQSATTTMPADLATAVCAQQALFPALKYRFQYLYTSPDMARQQWRTDHVVPLLRLFPLLGAPAAEDLAAQLVVEGEWAKLGIEADTNLLQDTVWRPLKDMVEQMSALYETNVDAVLKHMEDGARVLCPPLSERESLIMHGAPEDTKKEVSIAAAAAAANAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H8C1</accession>
    <name>A0A836H8C1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">proline--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Prolyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_07124</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(Pro) + L-proline + ATP = L-prolyl-tRNA(Pro) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="1"/>
    <dbReference type="EMBL" id="JAFHLR010000018">
        <property type="protein sequence ID" value="KAG5481412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064091.1">
        <property type="nucleotide sequence ID" value="XM_067209028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H8C1"/>
    <dbReference type="SMR" id="A0A836H8C1"/>
    <dbReference type="GeneID" id="92362962"/>
    <dbReference type="KEGG" id="loi:92362962"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00862">
        <property type="entry name" value="ProRS_anticodon_zinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00778">
        <property type="entry name" value="ProRS_core_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.110.30:FF:000001">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000007">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000005">
        <property type="entry name" value="bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.960.10:FF:000005">
        <property type="entry name" value="Putative prolyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.30">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="entry name" value="YbaK/aminoacyl-tRNA synthetase-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01571">
        <property type="entry name" value="Pro_tRNA_synth_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004499">
        <property type="entry name" value="Pro-tRNA-ligase_IIa_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016061">
        <property type="entry name" value="Pro-tRNA_ligase_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017449">
        <property type="entry name" value="Pro-tRNA_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033721">
        <property type="entry name" value="ProRS_core_arch_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00408">
        <property type="entry name" value="proS_fam_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382:SF2">
        <property type="entry name" value="BIFUNCTIONAL GLUTAMATE_PROLINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382">
        <property type="entry name" value="PROLYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09180">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SMART" id="SM00946">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64586">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="YbaK/ProRS associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="10">
        <location>
            <begin position="365"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="46"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="50"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5481412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="818" mass="90695" checksum="EE1373775C3515EB" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H8W0</accession>
    <name>A0A836H8W0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05721</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063426.1">
        <property type="nucleotide sequence ID" value="XM_067207653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H8W0"/>
    <dbReference type="SMR" id="A0A836H8W0"/>
    <dbReference type="GeneID" id="92361587"/>
    <dbReference type="KEGG" id="loi:92361587"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5479715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="21947" checksum="60F152E2E5F3AD45" modified="2021-09-29" version="1">MECPRSRPGGEEIRVFQSTLDKRTVTTSVFAQPSFYMGLGSALVMVLTQRFPEEFMPRQYLTMSYNGIRASSLLTIPFCTISGVFFSISSVVTAAPTPLVGHLLGYGFSVGVGLTMLSLRRVSWYYPLLGLMYLCFGGLHHYRKLMVHGDNAPLFYWSDFGEIYRDRKAYRQEKRRRTEEKKAAVRQDRAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HAE0</accession>
    <name>A0A836HAE0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_07457</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000004">
        <property type="protein sequence ID" value="KAG5487779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065976.1">
        <property type="nucleotide sequence ID" value="XM_067209344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HAE0"/>
    <dbReference type="SMR" id="A0A836HAE0"/>
    <dbReference type="GeneID" id="92363278"/>
    <dbReference type="KEGG" id="loi:92363278"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5487779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="18255" checksum="27A2CE68413D0BAC" modified="2021-09-29" version="1">MAQWIPKTAWTVSNLNKRYGLPYVAKGYTSLDPECSLDAYSSLQQTMTSADVKKALLSTRCASSGALVIDVRSEPERRLRPLLSPVIVALHPHDILSGAACPILPSNKEMAEMFVMASEAQRAVNTCTALRRWGYSRVFVVNVDAVSGAIEEARKPEVTATISSRNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HB37</accession>
    <name>A0A836HB37_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_08131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000002">
        <property type="protein sequence ID" value="KAG5488154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066202.1">
        <property type="nucleotide sequence ID" value="XM_067210004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HB37"/>
    <dbReference type="GeneID" id="92363938"/>
    <dbReference type="KEGG" id="loi:92363938"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37332:SF1">
        <property type="entry name" value="ELMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37332">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5488154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="397" mass="43434" checksum="B827F1ECC8D9F2BB" modified="2021-09-29" version="1">MLKKVLKIKGVEGRTALVEFAVNKRVKYLEYLKELHSEEGALWMNTVHLDLHEIGKYFNIDDACLPTDRDSGSKEGLIHLPAELPVEMAATATGALASSSSHASAESGGAGVGFITVSIANAPAAIQQRSSSAADWARYYLPCYAALAISLSEILLIPIGGEEFVECFYGVLLELEVAYATGAASKALAQRNLRQFRQRVSAGLKSLLQTSTDVEARDATPTSPLATPSSEHDVQIKYLFLDQRHLEYTAASPSYDAVIPALCSVLMFAYRKLCDYELMREEECVRRILSIDKRLERLFFGHVSHELDKIANHKLLREAYILSPGALFADLVQASGPSGACSPVAINGGADFVADLLIQQQQRRGLSDPTAVGKKAFDSSDDDEEDESIWYGPEEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HBE0</accession>
    <name>A0A836HBE0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-editing substrate-binding complex 6 protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061702.1">
        <property type="nucleotide sequence ID" value="XM_067205765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HBE0"/>
    <dbReference type="SMR" id="A0A836HBE0"/>
    <dbReference type="GeneID" id="92359699"/>
    <dbReference type="KEGG" id="loi:92359699"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23734">
        <property type="entry name" value="RESC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058917">
        <property type="entry name" value="RESC6_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26188">
        <property type="entry name" value="RESC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA-editing substrate-binding complex 6 protein" evidence="1">
        <location>
            <begin position="873"/>
            <end position="1027"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5474596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1157" mass="124012" checksum="F3C7F4B74F2FDBA5" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HCP2</accession>
    <name>A0A836HCP2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cysteine-S-conjugate beta-lyase</fullName>
            <ecNumber evidence="3">4.4.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cysteine-S-conjugate beta-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_04874</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.13" evidence="3"/>
    <dbReference type="EMBL" id="JAFHLR010000014">
        <property type="protein sequence ID" value="KAG5483722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064661.1">
        <property type="nucleotide sequence ID" value="XM_067206852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HCP2"/>
    <dbReference type="SMR" id="A0A836HCP2"/>
    <dbReference type="GeneID" id="92360786"/>
    <dbReference type="KEGG" id="loi:92360786"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047804">
        <property type="term" value="F:cysteine-S-conjugate beta-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000046">
        <property type="entry name" value="Cystathionine gamma-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006238">
        <property type="entry name" value="Cys_b_lyase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01329">
        <property type="entry name" value="cysta_beta_ly_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF50">
        <property type="entry name" value="CYSTATHIONINE BETA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <begin position="327"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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            <begin position="22"/>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="KAG5476035.1"/>
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    </evidence>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
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        </recommendedName>
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        </alternativeName>
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        <name type="scientific">Leishmania orientalis</name>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
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            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476173.1"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00031345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="KAG5476173.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1006" mass="107670" checksum="D91629F22D521061" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HGE2</accession>
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        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Leishmania</taxon>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000010">
        <property type="protein sequence ID" value="KAG5485702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067208575.1"/>
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    <dbReference type="GeneID" id="92362509"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045117">
        <property type="entry name" value="ATXN2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009604">
        <property type="entry name" value="LsmAD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025852">
        <property type="entry name" value="SM_dom_ATX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854">
        <property type="entry name" value="ATAXIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854:SF7">
        <property type="entry name" value="ATAXIN-2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06741">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14438">
        <property type="entry name" value="SM-ATX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01272">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LsmAD" evidence="2">
        <location>
            <begin position="149"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="234"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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                <person name="Bates M.D."/>
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                <person name="Bates M.D."/>
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    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MOG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000023">
        <property type="protein sequence ID" value="KAG5478558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063219.1">
        <property type="nucleotide sequence ID" value="XM_067206772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HKZ3"/>
    <dbReference type="SMR" id="A0A836HKZ3"/>
    <dbReference type="GeneID" id="92360706"/>
    <dbReference type="KEGG" id="loi:92360706"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.10">
        <property type="entry name" value="Mog1/PsbP, alpha/beta/alpha sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007681">
        <property type="entry name" value="Mog1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016123">
        <property type="entry name" value="Mog1/PsbP_a/b/a-sand"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15837">
        <property type="entry name" value="RAN GUANINE NUCLEOTIDE RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15837:SF0">
        <property type="entry name" value="RAN GUANINE NUCLEOTIDE RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04603">
        <property type="entry name" value="Mog1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55724">
        <property type="entry name" value="Mog1p/PsbP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5478558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="23034" checksum="E179C87DA0A80905" modified="2021-09-29" version="1">MAAARTVDLYGGAMRICLPQTMADASNFRQVPDNQEVYVDADTGASVIVELLRRQASVGNAEAGVFFFHDLAKDNGCPPECISQEETFTLPPSAYPHLVAIADPVAPAACGSVAPQSCDFACITTGLQRISKFSNESGKENVVFVGLAVLRFTPPVSTEVLISVSCPTWLHPESSEVRVVKRLLSEHERLQLLQTAVASLEIVEWGLFVPEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HLW0</accession>
    <name>A0A836HLW0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_01789</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">LSCM4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. MAK3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000022">
        <property type="protein sequence ID" value="KAG5479200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063293.1">
        <property type="nucleotide sequence ID" value="XM_067203834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HLW0"/>
    <dbReference type="SMR" id="A0A836HLW0"/>
    <dbReference type="GeneID" id="92357768"/>
    <dbReference type="KEGG" id="loi:92357768"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004596">
        <property type="term" value="F:protein-N-terminal amino-acid acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000255">
        <property type="entry name" value="N-acetyltransferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044542">
        <property type="entry name" value="NAA30-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="5">
        <location>
            <begin position="108"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5479200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="294" mass="33020" checksum="81D7D57322C90345" modified="2021-09-29" version="1">MPPKSATKKNQKLSKQRDHFDEAAIDALVRAIEGKTKKGTTKSQLKQKEDKSRSRVNGNNYVLSEQMRNALLAQMQQSAAQGEEYVNVPVPLTGEEKEWQEIAPKKYIRYEQFGGSDEEMNFIVDLFTAELTEPYSSFTYQYFVFGWPDLCITAFGVESETKPDKSVVGEKVGAVVSRVTRKGADMPLRGYLAMFAVVPSFRGYRLGSRLVSLTVALMREKDCDEVYLETPTSNVRALGLYLNLGFAKTKFLPRYYLDHSDAVRLKLWLKDAVPKSAPDATAVSAVEEKAGAYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HMX7</accession>
    <name>A0A836HMX7_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_05747</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063451.1">
        <property type="nucleotide sequence ID" value="XM_067207678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HMX7"/>
    <dbReference type="GeneID" id="92361612"/>
    <dbReference type="KEGG" id="loi:92361612"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040000">
        <property type="entry name" value="NOP9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102">
        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="636"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="683"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="693"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5479740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="768" mass="82733" checksum="FBA3ADE0BF69B2B6" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HQI0</accession>
    <name>A0A836HQI0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_06421</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000019">
        <property type="protein sequence ID" value="KAG5480853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063854.1">
        <property type="nucleotide sequence ID" value="XM_067208342.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836HQI0"/>
    <dbReference type="GeneID" id="92362276"/>
    <dbReference type="KEGG" id="loi:92362276"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="517"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="546"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="2054"/>
            <end position="2142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="257"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="337"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="626"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="795"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="840"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1618"/>
            <end position="1681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1937"/>
            <end position="1974"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1998"/>
            <end position="2048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="350"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="636"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="795"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="818"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="851"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="881"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1618"/>
            <end position="1638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1959"/>
            <end position="1969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="2028"/>
            <end position="2041"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5480853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="2159" mass="228577" checksum="66767E6309345EFA" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HW44</accession>
    <name>A0A836HW44_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_05987</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000011">
        <property type="protein sequence ID" value="KAG5485351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065088.1">
        <property type="nucleotide sequence ID" value="XM_067207914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HW44"/>
    <dbReference type="GeneID" id="92361848"/>
    <dbReference type="KEGG" id="loi:92361848"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="196"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="66"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5485351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="578" mass="63306" checksum="FA1B074F5E6E4712" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HX19</accession>
    <name>A0A836HX19_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Pyrroline-5-carboxylate reductase</fullName>
            <ecNumber evidence="12">1.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LSCM4_08002</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">LSCM4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-proline + NAD(+) = (S)-1-pyrroline-5-carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14105"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>L-proline + NADP(+) = (S)-1-pyrroline-5-carboxylate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="12">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="12"/>
    <dbReference type="EMBL" id="JAFHLR010000013">
        <property type="protein sequence ID" value="KAG5484435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064928.1">
        <property type="nucleotide sequence ID" value="XM_067209878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HX19"/>
    <dbReference type="SMR" id="A0A836HX19"/>
    <dbReference type="GeneID" id="92363812"/>
    <dbReference type="KEGG" id="loi:92363812"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3730.10:FF:000001">
        <property type="entry name" value="Pyrroline-5-carboxylate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000190">
        <property type="entry name" value="Pyrroline-5-carboxylate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.10">
        <property type="entry name" value="ProC C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053790">
        <property type="entry name" value="P5CR-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645:SF0">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00521">
        <property type="entry name" value="P5CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11 12" id="KW-0521">NADP</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 12" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="13">
        <location>
            <begin position="5"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase dimerisation" evidence="14">
        <location>
            <begin position="162"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="9"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000193-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG5484435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="272" mass="28717" checksum="012DCEC5BBA46C69" modified="2021-09-29" version="1">MAEQKIGFLGCGSMAECIMAGLLKAKAFTPENTFICNRTATTNERLVSVYQVNSVSAAELAERCDIVMLGVKPHVIVPVLENIKAKITPSKLVISMAAGVPIATIENHCPPKTKVIRVMPNIPSFVGEGVTSVSSNSAVTPEDEAAVVKLFSAIGKAYVVAESAIHGVIGVAGSSPAYVFMFMEALSDGAVRGGIPRAQSYEMAAQAVLGAARMLQESGKTPGALKDMVCSPGGTTIEAVRFLEKGGMRSAVIEAMIHCMEKSKEFERLYSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HXW9</accession>
    <name>A0A836HXW9_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_07642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000012">
        <property type="protein sequence ID" value="KAG5484870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064982.1">
        <property type="nucleotide sequence ID" value="XM_067209522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HXW9"/>
    <dbReference type="GeneID" id="92363456"/>
    <dbReference type="KEGG" id="loi:92363456"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="635"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5484870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="791" mass="83740" checksum="178ACED2280E135D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HZN2</accession>
    <name>A0A836HZN2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal eL28/Mak16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_06051</name>
        <name evidence="6" type="ORF">LSCM4_06053</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">LSCM4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000011">
        <property type="protein sequence ID" value="KAG5485413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFHLR010000011">
        <property type="protein sequence ID" value="KAG5485415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065150.1">
        <property type="nucleotide sequence ID" value="XM_067207976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HZN2"/>
    <dbReference type="SMR" id="A0A836HZN2"/>
    <dbReference type="GeneID" id="92361910"/>
    <dbReference type="KEGG" id="loi:92361910"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.110:FF:000007">
        <property type="entry name" value="60S ribosomal protein L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002672">
        <property type="entry name" value="Ribosomal_eL28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029004">
        <property type="entry name" value="Ribosomal_eL28/Mak16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10544">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01778">
        <property type="entry name" value="Ribosomal_L28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal eL28/Mak16" evidence="4">
        <location>
            <begin position="7"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5485413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5485415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="147" mass="16189" checksum="F6C6953D1E6B24A0" modified="2021-09-29" version="1">MSHSADLQWILVRQNSRFLQKRGGVRLSSDPFNNNGNWTKRHSGFLNKKAAVVKLAKGGAICVTVKDGSSNNKPKQTYKKSVQVAGVRASDVSRAVAAVRPDLADVAFRRARRMACIVSRTAKVAAARKARSAKIKFSRKSVRPKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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                <person name="Bates M.D."/>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
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        <source>
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        <source>
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        </source>
    </evidence>
    <sequence length="204" mass="22284" checksum="601D1942D7D51332" modified="2021-09-29" version="1">MGKEDRIYDILFNMKFASKQMTKSATASEKSAEREKLNVKKALEKGNPEAARIYAENAIRKRNESLNYLRLASRLDAASSRIQTAMQMQTVTKTMSTTVKGMDKILTSMDPMKIAKVMDAFERQVGTMDVSLGTMDAAFESSSAGTVPVTQVDSLMEQVAAENNIDLSAKLGNAPLGSGIAMPERKHDVTEDDIAGRLKALQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KFX7</accession>
    <name>A0A836KFX7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Surface antigen-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_01914</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060992.1">
        <property type="nucleotide sequence ID" value="XM_067203955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KFX7"/>
    <dbReference type="GeneID" id="92357889"/>
    <dbReference type="KEGG" id="loi:92357889"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032879116" description="Surface antigen-like protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5472596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="136" mass="13727" checksum="1B22BD86F4B5FEF4" modified="2021-09-29" version="1">MTSKYLVVLTLLLAIATIAAAQQCPPGQTAVNGQCVFNCQAANCDICDPHDPTHTACATCSFGYILDAKKVCRPACTIANCVTCSSSGNNACQECASGYLRTASGHCKRSGSSGSTVVSVAVASAVVVASVFAIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KG91</accession>
    <name>A0A836KG91_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_01366</name>
        <name evidence="7" type="ORF">LSCM4_02297</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">LSCM4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059111.1">
        <property type="nucleotide sequence ID" value="XM_067203420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KG91"/>
    <dbReference type="SMR" id="A0A836KG91"/>
    <dbReference type="GeneID" id="92357354"/>
    <dbReference type="KEGG" id="loi:92357354"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1120.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1120.10">
        <property type="entry name" value="Ribosomal protein l15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024794">
        <property type="entry name" value="Rbsml_eL15_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000439">
        <property type="entry name" value="Ribosomal_eL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003269">
        <property type="entry name" value="PRK04243.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847">
        <property type="entry name" value="RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00827">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01384">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="168"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5466221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5472971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="204" mass="24408" checksum="A5EAF6019DAF4311" modified="2021-09-29" version="1">MGAFMYLNELWKKKSSDVMRFIQRIRSWEFRHQHTVVRLRRPTRPEKARMLGYKTKQGFCVFRVRVRRGGRKRPAHKGITYGKPKTSGVLGMKLNKNNQAVAEQRLGKRFGNLRVLNSYWVNMDSTFKWYEVIAVDPMCKTIRRDPRINWIVNSVHKHREQRGLTSAGRKHRGLRHKGHKASKLRPSYRAAWRRNNRIVFLRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KGT7</accession>
    <name>A0A836KGT7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_02919</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060491.1">
        <property type="nucleotide sequence ID" value="XM_067204939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KGT7"/>
    <dbReference type="SMR" id="A0A836KGT7"/>
    <dbReference type="GeneID" id="92358873"/>
    <dbReference type="KEGG" id="loi:92358873"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004128">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000069">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF79">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0274">FAD</keyword>
    <keyword evidence="3 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032895981" description="FAD-binding FR-type domain-containing protein" evidence="10">
        <location>
            <begin position="17"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="11">
        <location>
            <begin position="39"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5470225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="338" mass="37313" checksum="6B94E0BF05B04621" modified="2021-09-29" version="1">MVKFLTFGAAAALGAAFHTFTSSQRAVAECAAKKEVFTTKFKPFVLGEVLNLAEDVAIFRFLLTDPSDVFDLVPCSTLQAHFKEGANMVDQPMRFYTPITPNGTKGYFDLLVKKQRPGRFTEHLFSMDVGESLLFRVVQYKLTYKKNRWTDVGMICGGTGLCPILQFMNASLETEGDSTKLSMLFANRSENKILLKGMLDEKAREHKDRLQIFYTVDTFDDANMISNPVFKKGVPLKVDVESQPSTSPDGKKYFQGFKGHIDVPMLQATMPKPSPSTLLLVCGPDPMMVKVVGAAPMVLRAMSGGLAYQPSGAVLNNAADVSGFLGSLGYQKEMVYRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KII7</accession>
    <name>A0A836KII7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Zinc finger protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_04088</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062014.1">
        <property type="nucleotide sequence ID" value="XM_067206077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KII7"/>
    <dbReference type="SMR" id="A0A836KII7"/>
    <dbReference type="GeneID" id="92360011"/>
    <dbReference type="KEGG" id="loi:92360011"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035329">
        <property type="term" value="P:hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051252">
        <property type="term" value="P:regulation of RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000035">
        <property type="entry name" value="Salvador homolog 1 (Drosophila)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000003">
        <property type="entry name" value="Zinc finger CCCH domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030030">
        <property type="entry name" value="Sav"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47522:SF2">
        <property type="entry name" value="PROTEIN SALVADOR HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47522">
        <property type="entry name" value="SALVADOR FAMILY WW DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="WW" evidence="7">
        <location>
            <begin position="10"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="69"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="69"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5475506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="114" mass="12948" checksum="B6B62083E263BC6D" modified="2021-09-29" version="1">MQQAYFGQQPMLPPGWQLSYTADGKPYYIDHNTKTTHWTIPPTAYEPYYNGRGRGAGYRGGRQGIDRSKMKSKMCIYWEKNGNCAWGDRCAFAHGTEELRNPVNQPRNDAPASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KJ22</accession>
    <name>A0A836KJ22_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein disulfide-isomerase</fullName>
            <ecNumber evidence="3">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_05047</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="3"/>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062324.1">
        <property type="nucleotide sequence ID" value="XM_067207021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KJ22"/>
    <dbReference type="SMR" id="A0A836KJ22"/>
    <dbReference type="GeneID" id="92360955"/>
    <dbReference type="KEGG" id="loi:92360955"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02998">
        <property type="entry name" value="PDI_a_ERp38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1150.12">
        <property type="entry name" value="Endoplasmic reticulum resident protein 29, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011679">
        <property type="entry name" value="ERp29_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036356">
        <property type="entry name" value="ERp29_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051063">
        <property type="entry name" value="PDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672:SF11">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07749">
        <property type="entry name" value="ERp29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47933">
        <property type="entry name" value="ERP29 C domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
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    </dbReference>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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        </source>
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            <dbReference type="EMBL" id="KAG5476091.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
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    </evidence>
    <sequence length="378" mass="41177" checksum="82E72DC9AAEE176B" modified="2021-09-29" version="1">MCRRLSAVLVLVLVVFVAVASCSGEDPSADVPGVMQLNKDNFDEVVGKERAVLVEFYAPWCGHCKRLAPEYAALGAAYENSESAKELLVIAKVNAADEKALGKRFKIEGFPTILFFPPGSKKPEVYKGGRSADDFAVYLSSKVNDLVLIIPKVPQFVKELVHSTFEEIVKDPSKAMLVFFYTTWCGNCKTLKPIYNELAKAFAGDKDVLIASLNVGEEAHRKYANKYVTSGLPVLYFFPKDIDAKPVEYTGGHNLQDLLSFVNANAGTHRLANGDPSPDYGIIDELAEAAARVAESSGESAKEEVEALKAAAAKLAKSEAAAYYIKAAESMAVKGVVHVENELARLQRLLGGSMAGARRDNAVMRINILSSIQKYMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KK29</accession>
    <name>A0A836KK29_9TRYP</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">LSCM4_03564</name>
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    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG5473495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="KEGG" id="loi:92359495"/>
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    </dbReference>
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            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="601"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5473495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="625" mass="68856" checksum="95EA27314CB414B9" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KK60</accession>
    <name>A0A836KK60_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA polymerase delta subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_04494</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Discoba</taxon>
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        </lineage>
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    <reference evidence="6 7" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">LSCM4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase delta/II small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="loi:92360412"/>
    <dbReference type="Proteomes" id="UP000674143">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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            <end position="216"/>
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            <end position="401"/>
        </location>
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            <end position="507"/>
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            <begin position="115"/>
            <end position="155"/>
        </location>
    </feature>
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        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
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        <location>
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            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006035"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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    </evidence>
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            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF18018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5477276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="591" mass="63857" checksum="5B75DB6586B6CE9B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KKW4</accession>
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        <recommendedName>
            <fullName evidence="5">SET domain-containing protein</fullName>
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    </gene>
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        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5478071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062978.1">
        <property type="nucleotide sequence ID" value="XM_067207410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KKW4"/>
    <dbReference type="GeneID" id="92361344"/>
    <dbReference type="KEGG" id="loi:92361344"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042799">
        <property type="term" value="F:histone H4K20 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045814">
        <property type="term" value="P:negative regulation of gene expression, epigenetic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46402:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-TRIMETHYLTRANSFERASE SMYD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46402">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="5">
        <location>
            <begin position="646"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="236"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="197"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5478071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="732" mass="78170" checksum="3585B8CF640F8C73" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KN15</accession>
    <name>A0A836KN15_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000020">
        <property type="protein sequence ID" value="KAG5480411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063742.1">
        <property type="nucleotide sequence ID" value="XM_067208102.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92362036"/>
    <dbReference type="KEGG" id="loi:92362036"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="629"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="773"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1056"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1178"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1280"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="657"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="775"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1062"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1095"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1178"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1315"/>
            <end position="1326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5480411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1326" mass="139111" checksum="83D6795CF56A5176" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KNI9</accession>
    <name>A0A836KNI9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_06507</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000019">
        <property type="protein sequence ID" value="KAG5480936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063937.1">
        <property type="nucleotide sequence ID" value="XM_067208425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KNI9"/>
    <dbReference type="GeneID" id="92362359"/>
    <dbReference type="KEGG" id="loi:92362359"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03390">
        <property type="entry name" value="PAP2_containing_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.144.10:FF:000037">
        <property type="entry name" value="Phosphatidic acid phosphatase protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF35">
        <property type="entry name" value="RE23632P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="8">
        <location>
            <begin position="142"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="327"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5480936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="400" mass="44259" checksum="5A83B7A0BE1521C2" modified="2021-09-29" version="1">MVEISKRKFYYVWNQFHLLDGIVLAMMLVIALIFTVLVKPHCRTFSWNDATIAYPSRADTFPSYSLALMLLCAMAFYVVFILFLVRPLQALFGEPLDWYNIGGANAGRGVDADAYEDMDARANTRPLRIRDIQTGRGLLYPWLRAQVWAFGLQFCVMAVLKVYAGRLRPDYLSRLKAAGYTSSNASLPDPQLNPEYYCALMDAHSSLKEGRLSFPSGHSSTSFAVCTVVSLFFVAHLRPFARQASFTRLVICLLPLIVSVMCAASRTRDNKHHFSDIIAGSLMGIASAFLSFYGCFRQVGGAAGIYFGRTAWDVEYDQLREWKDTGVGDGSGPAVKTASVGGGGTNCQSPNKREDSARRGPMLTAVRMSDAAVTFSDAVWRPAGLTERRLNEDPAAVPWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KQX9</accession>
    <name>A0A836KQX9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trypanosoma Tc-38 (p38) protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000016">
        <property type="protein sequence ID" value="KAG5482287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064293.1">
        <property type="nucleotide sequence ID" value="XM_067207479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KQX9"/>
    <dbReference type="GeneID" id="92361413"/>
    <dbReference type="KEGG" id="loi:92361413"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045399">
        <property type="entry name" value="Tc-38"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20054">
        <property type="entry name" value="Tc-38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trypanosoma Tc-38 (p38) protein" evidence="1">
        <location>
            <begin position="129"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5482287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="327" mass="36322" checksum="E8A5D262F8230F96" modified="2021-09-29" version="1">MAHFLVPQPSERMLGGLSRTLCGHVFSAEHHHHLCAIARARGWAGRVWVPVPVMELLSLPLSRKTFAPARLTSSNGSVWVYHSSQFIAPLDAMQERWNARVRCLEADEKNRDETLMASRVAPASLPLSTNGERFDSVTEDCMLRSVGSRGSASRYWATEAEAAWLYRTPFTDAYLSNPGNCVVSHANELCRPLALYNVEGTVNPSRFTKLTCRRYDPVNYNGRFYRPAAALRMKAFALQYDCLDESQWITPRRAARLGLSLIPHVKPLLFSLELPLFLISIGATQRTSAPASVAPPAVAAVSAVAREDDIDICEGQREKSLLTEPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KRL6</accession>
    <name>A0A836KRL6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Leucine-rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_07667</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000012">
        <property type="protein sequence ID" value="KAG5484894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065006.1">
        <property type="nucleotide sequence ID" value="XM_067209546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KRL6"/>
    <dbReference type="GeneID" id="92363480"/>
    <dbReference type="KEGG" id="loi:92363480"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052410">
        <property type="entry name" value="DRC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24107:SF2">
        <property type="entry name" value="NLR FAMILY CARD DOMAIN CONTAINING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24107">
        <property type="entry name" value="YNEIN REGULATORY COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="787"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5484894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="848" mass="91073" checksum="5B616AF89707D35A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KSW1</accession>
    <name>A0A836KSW1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine/threonine specific protein phosphatases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_07984</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000013">
        <property type="protein sequence ID" value="KAG5484417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064910.1">
        <property type="nucleotide sequence ID" value="XM_067209860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KSW1"/>
    <dbReference type="SMR" id="A0A836KSW1"/>
    <dbReference type="GeneID" id="92363794"/>
    <dbReference type="KEGG" id="loi:92363794"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF514">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="2">
        <location>
            <begin position="378"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5484417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="693" mass="75237" checksum="1F5E8E43B5E95724" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KT87</accession>
    <name>A0A836KT87_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Inositol-1-monophosphatase</fullName>
            <ecNumber evidence="3">3.1.3.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_06989</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a myo-inositol phosphate + H2O = myo-inositol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24056"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:84139"/>
            <dbReference type="EC" id="3.1.3.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.25" evidence="3"/>
    <dbReference type="EMBL" id="JAFHLR010000017">
        <property type="protein sequence ID" value="KAG5481910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064270.1">
        <property type="nucleotide sequence ID" value="XM_067208896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KT87"/>
    <dbReference type="SMR" id="A0A836KT87"/>
    <dbReference type="GeneID" id="92362830"/>
    <dbReference type="KEGG" id="loi:92362830"/>
    <dbReference type="UniPathway" id="UPA00823">
        <property type="reaction ID" value="UER00788"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01639">
        <property type="entry name" value="IMPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000033">
        <property type="entry name" value="Inositol-1-monophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033942">
        <property type="entry name" value="IMPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20854">
        <property type="entry name" value="INOSITOL MONOPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20854:SF22">
        <property type="entry name" value="INOSITOL-1-MONOPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5481910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="308" mass="32720" checksum="A3A669B0B096F7B3" modified="2021-09-29" version="1">MSASRMQFSITEEELDYALDLAIRAANTAAFIMNRAMDERINGIAESLAKANQADLVMPYEKQCREEVLHILRTGTPTYAVLSEDAHSGGVLSDGPTWIVGPIDGTVSFAHGLFDCCVSIALAVRKEPLLGVVCAPHLQEVFTAVKNRGAFSNGQRIHVSLVTSLKESVVLLHHGYNRSDAAVKSVTAMQAELAKLPVHGLRSSGSAALDMCLVAAGRAELYWEVGVKPWNVAAGVIIVREAGGVVHSVESAEYFDLTGGSVCCGCSLDITTHGVELSRKHNYRNSLLSKSSLGALAHGGACSRETGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KUK2</accession>
    <name>A0A836KUK2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LSCM4_08011</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">LSCM4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
            <location evidence="2 13">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the dynein light chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000005">
        <property type="protein sequence ID" value="KAG5487566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065854.1">
        <property type="nucleotide sequence ID" value="XM_067209887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KUK2"/>
    <dbReference type="SMR" id="A0A836KUK2"/>
    <dbReference type="GeneID" id="92363821"/>
    <dbReference type="KEGG" id="loi:92363821"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21452">
        <property type="entry name" value="DLC-like_DYNLL1_DYNLL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.740.10:FF:000005">
        <property type="entry name" value="Dynein light chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019763">
        <property type="entry name" value="Dynein_light_1/2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886:SF90">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01239">
        <property type="entry name" value="DYNEIN_LIGHT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9 13" id="KW-0243">Dynein</keyword>
    <keyword evidence="6 13" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10 13" id="KW-0505">Motor protein</keyword>
    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG5487566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="91" mass="10673" checksum="D3FC020CF51FCCB7" modified="2021-09-29" version="1">MPLKYSEMSYNADMPKDMIQEAQNVIIEAFETEYLENAVATHIKREFMKKYKGVWHCVVGKNFGSFVTHEMKGYIYVTWGQISVLLWKTVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KVN0</accession>
    <name>A0A836KVN0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4833 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_05806</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063509.1">
        <property type="nucleotide sequence ID" value="XM_067207736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KVN0"/>
    <dbReference type="GeneID" id="92361670"/>
    <dbReference type="KEGG" id="loi:92361670"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5479798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="381" mass="41620" checksum="B4D761D96EDBF461" modified="2021-09-29" version="1">MTMPLAASGKTVKEDSELFFAVTRSFSLPGVSSHYAAPHAFGQLMRSRLRQRNRFNHDHHDTFVYIERSKNANVVAYTANLVDAATNEKVGSGIGRQCVLRSDDPVHAYFVNLEPSYVEDRRRKGIEYDCDDLNMLERTLAYGFSATPVNTEDILQYWGRHTPEAFAALQAEWKAGGSVGMLGEGQGSTGDETAAPLSAIALTVESVGAALKTWWAPFHPYISHFVAAPTYPTLILCLPPVAKLVGSSRCSSVAASAEQIPTAPNQGRAADTMEEKPPTVDKTNVTYGSHTEPAEATATSGVLSDEDTVVATIALIGGELSVLEKVYVKSIEPKRFYNLPKKVYVASVEPKHFYQLPKVEYVEVHGTSLETGAPTYEKRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KW09</accession>
    <name>A0A836KW09_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Beta-fructofuranosidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_07483</name>
        <name evidence="9" type="ORF">LSCM4_07484</name>
        <name evidence="10" type="ORF">LSCM4_07485</name>
        <name evidence="11" type="ORF">LSCM4_07586</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">LSCM4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000004">
        <property type="protein sequence ID" value="KAG5487805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFHLR010000004">
        <property type="protein sequence ID" value="KAG5487806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFHLR010000004">
        <property type="protein sequence ID" value="KAG5487807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFHLR010000004">
        <property type="protein sequence ID" value="KAG5487904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066002.1">
        <property type="nucleotide sequence ID" value="XM_067209370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KW09"/>
    <dbReference type="SMR" id="A0A836KW09"/>
    <dbReference type="GeneID" id="92363304"/>
    <dbReference type="KEGG" id="loi:92363304"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18624">
        <property type="entry name" value="GH32_Fruct1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050551">
        <property type="entry name" value="Fructan_Metab_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018053">
        <property type="entry name" value="Glyco_hydro_32_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31953">
        <property type="entry name" value="BETA-FRUCTOFURANOSIDASE, INSOLUBLE ISOENZYME CWINV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00609">
        <property type="entry name" value="GLYCOSYL_HYDROL_F32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044663497" description="Beta-fructofuranosidase" evidence="5">
        <location>
            <begin position="29"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 N-terminal" evidence="6">
        <location>
            <begin position="39"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 C-terminal" evidence="7">
        <location>
            <begin position="413"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5487805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5487806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5487807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5487904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="643" mass="72419" checksum="089B36DCE5DA36E3" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KWQ7</accession>
    <name>A0A836KWQ7_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000019">
        <property type="protein sequence ID" value="KAG5480863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063864.1">
        <property type="nucleotide sequence ID" value="XM_067208352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KWQ7"/>
    <dbReference type="GeneID" id="92362286"/>
    <dbReference type="KEGG" id="loi:92362286"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5480863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="271" mass="29756" checksum="D6E5F8A7EB2E8C3C" modified="2021-09-29" version="1">MLRICLLGHASALAPLRQRSAVAASAAAITTAVAAAGASQFQPRRAYATGARSTARERRYYSQPLRAPQYGTSTIVGRQESEADVAPAAATMSGEAPSPIAEEIATALDHRIGTVHPDSLTRSKPTDSLPKMRLVHFVVSHCRPVRYNDAGVPVEGSLLLLPWREQLRLCTAIFAALYITKTFFDVIRFELLYYGVWKVGYRNDDSLMKRLLYYGSTAMLATGLLFCFNLTFFLSACLVGRRQVAGYMLCNAFAKVMPHRTLQLLSSRVGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836L1C9</accession>
    <name>A0A836L1C9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tetratricopeptide repeat (TPR) protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_05984</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000011">
        <property type="protein sequence ID" value="KAG5485348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065085.1">
        <property type="nucleotide sequence ID" value="XM_067207911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836L1C9"/>
    <dbReference type="SMR" id="A0A836L1C9"/>
    <dbReference type="GeneID" id="92361845"/>
    <dbReference type="KEGG" id="loi:92361845"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050498">
        <property type="entry name" value="Ycf3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44858">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44858:SF1">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE SPINDLY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="72"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="183"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="239"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="8"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5485348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="406" mass="44928" checksum="A55D358864E5FC23" modified="2021-09-29" version="1">MPPKGHSKSSAKAQRAKAKKEKQLLEARMRLCEEKCAEARGYLEPTGRSAEPNFTKAKAAVDAAIEAYDASSLAFFMLGQWNRMQGMYEEAIESYSQALDLEPTNVQALEWRAHCYQAVHDYPHAIEDNTSIISLDPENDHAYNMRGLCVLQSSVPGLHLRSIDFKSCVRDFSTAVRLNEANYYAMANLGKAYEVQGHLDKAIEYYGKALDSSEHYTYARFRRGCTALCMAERLLLRREEEGSSESDAPEAASGSLKARDGSSTRHMAEAASSTSSRAPGGATTLKEVKTEVCRHMEEEKEARRVETLLKLADSDFSLLLDHTPEGKQLAADPAVVLNIGICALLCKNINRAEEHLMLAQDIVAKRPGLVEDGEAPPLENRDAFNSVLAIRLKELQKLKDIARSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836L1E0</accession>
    <name>A0A836L1E0_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_06015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000011">
        <property type="protein sequence ID" value="KAG5485378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065115.1">
        <property type="nucleotide sequence ID" value="XM_067207941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836L1E0"/>
    <dbReference type="SMR" id="A0A836L1E0"/>
    <dbReference type="GeneID" id="92361875"/>
    <dbReference type="KEGG" id="loi:92361875"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5485378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="438" mass="46849" checksum="D07E74E06D745DC2" modified="2021-09-29" version="1">MTTSIDDAVGAACSLPPHGPANMMSIYMTRYDYDYNRDPGLTGSGDGSGSCFARGISGDVRNRPAFAYGADTGNRDDRTIYQVDYTVKDRSVKNMARLAATVTGAVKSSCQDNGTAYQRDWYLPAISTHLVLADGSHPHTVYQDDFQAPRCGAGGTGNTAVCYAGAAATSYNADLLKPHGMVEDDGADLAPKITSKESLLPRKPKNPNAVWTPVFENTVDHNRTWNDCVAGDGVVGTYSCTSWDYGDTSQAHPSQLPLSLARSLAAHGLDVTANPNKAALLRQLAGANAASRSLRGSASVVPLDTSDRTNPQFLSTMEQKRCAVSRRLEKEHYVTMSISKSDFIGHGLLPELPGNPGGPADVRDTHSSPLATAGEMMAGQLTKTTRELGLLRNAHGALKSGEAHPASQVRTSVLSAMRKMEKVDSIDKADPHRHKLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FL70</accession>
    <name>A0A836FL70_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_00092</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058283.1">
        <property type="nucleotide sequence ID" value="XM_067202182.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836FL70"/>
    <dbReference type="GeneID" id="92356116"/>
    <dbReference type="KEGG" id="loi:92356116"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF56">
        <property type="entry name" value="MAPKK KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="598"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="1305"/>
            <end position="1565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="27"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1120"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1169"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="141"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1178"/>
            <end position="1187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5464652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1565" mass="170499" checksum="5B30880CB49008E7" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FVS5</accession>
    <name>A0A836FVS5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AMP deaminase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_02941</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060513.1">
        <property type="nucleotide sequence ID" value="XM_067204961.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836FVS5"/>
    <dbReference type="GeneID" id="92358895"/>
    <dbReference type="KEGG" id="loi:92358895"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003876">
        <property type="term" value="F:AMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000035">
        <property type="entry name" value="Probable amp deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006329">
        <property type="entry name" value="AMPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359:SF6">
        <property type="entry name" value="DEAMINASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19326">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="514"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="529"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5470247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1613" mass="179688" checksum="B939B04DB9250D5E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G1W7</accession>
    <name>A0A836G1W7_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_00049</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058240.1">
        <property type="nucleotide sequence ID" value="XM_067202139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G1W7"/>
    <dbReference type="GeneID" id="92356073"/>
    <dbReference type="KEGG" id="loi:92356073"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5464609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="444" mass="49236" checksum="5933830568977788" modified="2021-09-29" version="1">MESIKEEIYLVANIIDRLLAGNESLRADQLVPLVKRLRTAAGEISSVHSKPLPGLALSPTPRNTDGFESMVSGSRQGFFKLPPPKALTQFSAARKQTQKGPAFSPQLRKRRGSKVFISPDVSQSVCCALYNLLEGATRLLCASHGHIFVKRGDNMFSIANVSRKLAFPPLQVHHGCLGNSDAEVLGSSIALNRYIDEDGRKSAVLIFPIYKNPTGGGPGEPVATLHVERREHVFGPFTESDECTLYFASLFCGELMSRIPQLNFLEAFYDPSTQHIIAPFEPYYPAVLPSLKRNGAPTLGGAEKHFSEDPEYAAQAVSHLTEKMNAHIKGILVRRESVPASDTKPFAPGVAHMPSMLEIQAYVDNLLSCWRKNMLDNVDLLELDRGTQQDLKLVRRELAATRLQLAATTEKLRLYELDVTDYKREYGAMKSELNAYMDGLERLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G4I3</accession>
    <name>A0A836G4I3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine/threonine-protein kinase TOR</fullName>
            <ecNumber evidence="9">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LSCM4_00673</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="9"/>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058850.1">
        <property type="nucleotide sequence ID" value="XM_067202749.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836G4I3"/>
    <dbReference type="GeneID" id="92356683"/>
    <dbReference type="KEGG" id="loi:92356683"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016242">
        <property type="term" value="P:negative regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05169">
        <property type="entry name" value="PIKKc_TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000029">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000965">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000034">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009076">
        <property type="entry name" value="FRB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036738">
        <property type="entry name" value="FRB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024585">
        <property type="entry name" value="mTOR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026683">
        <property type="entry name" value="TOR_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF9">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08771">
        <property type="entry name" value="FRB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11865">
        <property type="entry name" value="mTOR_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01346">
        <property type="entry name" value="DUF3385"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01345">
        <property type="entry name" value="Rapamycin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47212">
        <property type="entry name" value="FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="12">
        <location>
            <begin position="1375"/>
            <end position="1947"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="11">
        <location>
            <begin position="2134"/>
            <end position="2455"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="13">
        <location>
            <begin position="2582"/>
            <end position="2614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG5465219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="2614" mass="291867" checksum="2B40B3C68F9E554F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G565</accession>
    <name>A0A836G565_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Membrane-trafficking protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_01681</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059419.1">
        <property type="nucleotide sequence ID" value="XM_067203728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G565"/>
    <dbReference type="SMR" id="A0A836G565"/>
    <dbReference type="GeneID" id="92357662"/>
    <dbReference type="KEGG" id="loi:92357662"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032588">
        <property type="term" value="C:trans-Golgi network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007273">
        <property type="entry name" value="SCAMP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10687:SF2">
        <property type="entry name" value="SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10687">
        <property type="entry name" value="SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN SCAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04144">
        <property type="entry name" value="SCAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5466529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="24769" checksum="21777CE25BC9B3F0" modified="2021-09-29" version="1">MTTITEWMVLEKERQNAARREALNIRSQRVSHLVEPDPNFPPECCCVKPIIYHNIREQVPIPQQRFMYILAGLYITLIALIIWNIVAALVAFTSGGSTSHFGLSFLYLLGLPGAWIAWYYNVYCAIVYSSRPRQLLALLGLLIGVGFDVWMAVGVVGFGGCGWFYALSLRDKVASFVLVLLSAILWSLHGFTLCVMMLRYWRVSGGLLKNAASIYRESIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G6C6</accession>
    <name>A0A836G6C6_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_01369</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059114.1">
        <property type="nucleotide sequence ID" value="XM_067203423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G6C6"/>
    <dbReference type="GeneID" id="92357357"/>
    <dbReference type="KEGG" id="loi:92357357"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5466224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="464" mass="48768" checksum="6C5ECD9E0BF068CC" modified="2021-09-29" version="1">MPCTCAVGRVPGTSIANKVASSTAATSSVLSSASSVDAGLSKNPASAAAHCFYCLCSVCGQELTDVPTVTCDACGSHTHITCARDAYSNEWLYDEVAAPSTAATAAGGRTVSLPNAALASAKSRRMPSAALASHDGEDTAGSPSPAAVLAAPSGLTLSPPLSRNSSQPSLLLSAQALRSAAARIDKEYNYYCHPDCAMGMEVLRNPQFHAALSRSVERVFAREWAHIRASLVSAGVLRDGKHDVNTMDDDAGKEETTLYSAYSPLESVAAAPVKVEGAEESTAASSFCPPPPSPTPTACCGVPQKGTHGCTSHANAAHISDVAACHPAVALEVLRLYHQLRAEAWAEYFEQERHHYGHPLFYPPPFLDIARDAAVGHVVEAASPQGQAARLYLLDRRTHPVGSAVAIPVGVLTRWQQPTAAPLIKENDSNNFVAESLERVVNDAVMPETVVVYRNCSEEGRVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G796</accession>
    <name>A0A836G796_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_00839</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059561.1">
        <property type="nucleotide sequence ID" value="XM_067202911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G796"/>
    <dbReference type="SMR" id="A0A836G796"/>
    <dbReference type="GeneID" id="92356845"/>
    <dbReference type="KEGG" id="loi:92356845"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5467759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="508" mass="58544" checksum="B39E28A5DDD6ED4F" modified="2021-09-29" version="1">MSRFSVCVGLRKASRVCVSAAFSAHRQLAHTSVSYGAAAVQPPAWIEQLRQDAKTTEKSISYDIKVYDELSWRRKCFTFHKELWDPMRMSSILRNRLCLGSEEAEYTVIGEAFVFPDREDSPVINEPQRVCTLLWDHNSPTEKVMIQLSEHFPPLLWHTVKPTLGALKKVFSEFLDVDATHMKKYLPYYEEVQSRIEIQMDEKLIGTLSPSHMKDKFIEDMRKRDPRSVELDYPNEHNIFLGLTSHFRLTEDQLMKKNPFVFGWPILLSDGNEYLEDTPLRMAAFRTVYSKSLLLFHTRLDLQVDHRQTHLPGDDVEDILLEMPVFCTVNYPTNTRLCGGRPLVQRFNQVMGTSYPLGMPVDVLAAFARENIVKGERELLEELKFLTAASQKAPEPERVFRVSEDQLSSNRIVGQLAYTIVYLALVNYPKFAEDVFKVYWKHPSDLVRVACAKGAHIVERQDLVEQLIQAESEGRCKTMLMASMHLHAGSHLAKTRDSERERVEKSFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G8K1</accession>
    <name>A0A836G8K1_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_04545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062738.1">
        <property type="nucleotide sequence ID" value="XM_067206529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G8K1"/>
    <dbReference type="SMR" id="A0A836G8K1"/>
    <dbReference type="GeneID" id="92360463"/>
    <dbReference type="KEGG" id="loi:92360463"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5477327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="375" mass="39970" checksum="5303B026BFB9EBC0" modified="2021-09-29" version="1">MDAGMSAAAASSLVLVDMGAPLQECLRRLCAQTARVAASLDAEQQHTLPGGTATPSVATLLSEYRAAASDTLGNLGNDTAQLRRRIALKLQRLQKERHIDLCSSAACADEVDSVITELPTVAAGVKTRSEAFGDPVKTSACAPSLSPLSCDAYAVQEDEEDDIFGWVTQRPSESLLATSEPAKSAAAPRQAATAAVAGTTAALAGEVRSGEGAVDSLLRRIARDLADMVECKCRYAATVEGVHQQLITLQRYAESLLNVQEGGNSSTADSLGARLQRLLTYQPSHKIASEAEQRVWQRAWTAVGCNTAPVLEVGTSIEMIDVAVLARANVQRYEALEKRWMALRQAYEAQVAQLNQRMALAALQLGEMEAMRKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G8W8</accession>
    <name>A0A836G8W8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DOP1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_03036</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DOP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060607.1">
        <property type="nucleotide sequence ID" value="XM_067205055.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836G8W8"/>
    <dbReference type="GeneID" id="92358989"/>
    <dbReference type="KEGG" id="loi:92358989"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040314">
        <property type="entry name" value="DOP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007249">
        <property type="entry name" value="DOP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042">
        <property type="entry name" value="DOPEY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042:SF24">
        <property type="entry name" value="PROTEIN DOPEY-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04118">
        <property type="entry name" value="Dopey_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DOP1 N-terminal" evidence="5">
        <location>
            <begin position="273"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="106"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="809"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1568"/>
            <end position="1591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1768"/>
            <end position="1790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2188"/>
            <end position="2223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1576"/>
            <end position="1591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5470341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG5469209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="entry name" value="BEACH_Domain"/>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
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                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <location>
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            <end position="29"/>
        </location>
    </feature>
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            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="EMBL" id="KAG5472891.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
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    </evidence>
    <sequence length="191" mass="21070" checksum="9B8607E38F060FB1" modified="2021-09-29" version="1">MPITANSLVRWSLAAVGVSGAGLGGAYVYKTYFRQHPARNDKIVQLAAIALSSEVVDKSLHDPEVLSQLCTFGLQVLTHPVVVAHLKKFFIHELTDDTPTRAALRTFVVRDVIQDAWVREELVGVAEDLVDSVTDNPDLFPERILAWLGESALKGVQADEFWWAVRRNSKAAGWVAFIGPPSLEMAFEAPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GEZ0</accession>
    <name>A0A836GEZ0_9TRYP</name>
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        <recommendedName>
            <fullName evidence="12">Peroxisome targeting signal 1 receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_01315</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
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    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <subcellularLocation>
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    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peroxisomal targeting signal receptor family.</text>
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    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="TPR_rpt"/>
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        <property type="entry name" value="GH08708P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10130">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 1 RECEPTOR PEX5"/>
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        <property type="entry name" value="TPR_16"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="6 8" id="KW-0802">TPR repeat</keyword>
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        <location>
            <begin position="469"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="503"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="281"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5466172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="623" mass="69675" checksum="D5144D9A2DBF9E63" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GF07</accession>
    <name>A0A836GF07_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LSCM4_01346</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059092.1">
        <property type="nucleotide sequence ID" value="XM_067203401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GF07"/>
    <dbReference type="SMR" id="A0A836GF07"/>
    <dbReference type="GeneID" id="92357335"/>
    <dbReference type="KEGG" id="loi:92357335"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14132">
        <property type="entry name" value="STKc_CK2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000459">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000088">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045216">
        <property type="entry name" value="CK2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="44"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="346"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="362"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG5466202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="371" mass="42463" checksum="FE34A686E933D0E1" modified="2021-09-29" version="1">MSSKSSHLPASDGTHRYAYVNVNKPSSYWDYDSLRVQWNSPDRYEVEQKIGRGKYSDVFLGVDTKVPRQVVIKVLKPVKKKKILRELMVLQTLKGGPNIVDLFDVVREPSSKTPSFVFEYVKSCDFRTVFPTFTDLEVRSYIFQVLVALEYAHSHGIMHRDVKPNNVCLDYKTGKLKLIDWGLAEFYHPATSYNARVASRYFKGPELLVELPMYDYRLDMWSLGCMLAAMIFIREPFFRGKDNTDQLVRIVKVLGTDDLQVYLKKHNVSLPPVLEATLGYHAKKPWRSFVNGQNEHLCPPEALAFLDKLLQYDHMKRIQAAEALMDPYFDPVRPKDFTLAGITAAAENGGGDTSACNEENEQEKKAPEMES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GFJ7</accession>
    <name>A0A836GFJ7_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059467.1">
        <property type="nucleotide sequence ID" value="XM_067203776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GFJ7"/>
    <dbReference type="GeneID" id="92357710"/>
    <dbReference type="KEGG" id="loi:92357710"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5466577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="103" mass="11460" checksum="8489155B6C98F6B0" modified="2021-09-29" version="1">MMAITSCRLLPNKWKFRSPAGVANPNKSFTWGRISARGCGSQYDQGIHAHVKGKARSANRAAPRGPIRSFAHEKGTLHAQQLRSELAPKTMTPTRRRIHCSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GIC8</accession>
    <name>A0A836GIC8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">P1/s1 nuclease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_02072</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclease type I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061145.1">
        <property type="nucleotide sequence ID" value="XM_067204108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GIC8"/>
    <dbReference type="SMR" id="A0A836GIC8"/>
    <dbReference type="GeneID" id="92358042"/>
    <dbReference type="KEGG" id="loi:92358042"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11010">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.575.10">
        <property type="entry name" value="P1 Nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008947">
        <property type="entry name" value="PLipase_C/P1_nuclease_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003154">
        <property type="entry name" value="S1/P1nuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146">
        <property type="entry name" value="ENDONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146:SF10">
        <property type="entry name" value="STRAND-SPECIFIC NUCLEASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02265">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48537">
        <property type="entry name" value="Phospholipase C/P1 nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032734872" description="P1/s1 nuclease" evidence="8">
        <location>
            <begin position="27"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5472749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="36956" checksum="0041175CDBA5FA23" modified="2021-09-29" version="1">MPAFLGCRLRLTTLSLLVLSCVLSVAEVLGWGCAGHMILAEIALRQLDPANEEKIEAMATRFAQSGPFPWSPDVVQAACWPDDVRRWQQNAMSTWHFIGKPYNPENVSTDPVEAVNAVSVSLDMITSLRNTKAPLYLLNFAWVHLTHIIGDLHQPLHSVSMYSHEYPHGDLGGNLIYVRVRGKTVKLHALWDNICTATPPYYKRPLSYTDAFAISSTADRLMDKYRFPRTMRTLVDVAQMAEESYAFAVNSSYADMKPGKPVSDEYLARCTEVAESRLTLGGYRLGYILNDLLSKITVDQETVDAYRAAAPKRGAAVTAGRQRVRIRGHSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GLS6</accession>
    <name>A0A836GLS6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_02750</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060323.1">
        <property type="nucleotide sequence ID" value="XM_067204771.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836GLS6"/>
    <dbReference type="GeneID" id="92358705"/>
    <dbReference type="KEGG" id="loi:92358705"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001274">
        <property type="entry name" value="Putative serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584:SF369">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="323"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="686"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1264"/>
            <end position="1528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="180"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1129"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="180"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="1292"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5470057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1529" mass="165806" checksum="D30F16C2C68A3031" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GLT6</accession>
    <name>A0A836GLT6_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_02766</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060338.1">
        <property type="nucleotide sequence ID" value="XM_067204786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GLT6"/>
    <dbReference type="SMR" id="A0A836GLT6"/>
    <dbReference type="GeneID" id="92358720"/>
    <dbReference type="KEGG" id="loi:92358720"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031332">
        <property type="term" value="C:RNAi effector complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000010">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000018">
        <property type="entry name" value="Serine/threonine-protein kinase 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000080">
        <property type="entry name" value="Staphylococcal_nuclease_homologue /Tudor_domain_containing_protein_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000081">
        <property type="entry name" value="Staphylococcal_nuclease_homologue /Tudor_domain_containing_protein_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000062">
        <property type="entry name" value="Tudor domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016685">
        <property type="entry name" value="Silence_cplx_Nase-comp_TudorSN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302">
        <property type="entry name" value="EBNA2 BINDING PROTEIN P100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302:SF2">
        <property type="entry name" value="STAPHYLOCOCCAL NUCLEASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017179">
        <property type="entry name" value="RISC-Tudor-SN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00318">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="Staphylococcal nuclease"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50830">
        <property type="entry name" value="TNASE_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TNase-like" evidence="8">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="8">
        <location>
            <begin position="170"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="8">
        <location>
            <begin position="352"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="8">
        <location>
            <begin position="536"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="7">
        <location>
            <begin position="746"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="306"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="334"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5470072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="926" mass="101621" checksum="8FF6B3363AC919F9" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GM34</accession>
    <name>A0A836GM34_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_01486</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059228.1">
        <property type="nucleotide sequence ID" value="XM_067203537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GM34"/>
    <dbReference type="SMR" id="A0A836GM34"/>
    <dbReference type="GeneID" id="92357471"/>
    <dbReference type="KEGG" id="loi:92357471"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990923">
        <property type="term" value="C:PET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052144">
        <property type="entry name" value="piRNA_biogenesis_EXD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46628">
        <property type="entry name" value="PIRNA BIOGENESIS PROTEIN EXD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46628:SF1">
        <property type="entry name" value="PIRNA BIOGENESIS PROTEIN EXD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="348"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5466338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="412" mass="45479" checksum="E595F92644C5D778" modified="2021-09-29" version="1">MKSCRFCDRAVLRRFARSTVTAPVRTILQSRLLSSSIHDVGGSNSSRATVTTTAGTTSWSSLSSSVSSLPVTGDCAAILKYPYQVIGTEKELEEAVGVLQRSRQIAIDIEAFCTPEANKTPQLGRISLVQTCSDVVPAVFLFDVLSLSVPVFTKAIQPVFHDDTVRKLFFDCRRDMEALSTQMNLVPKRVLDLQLFFTAVQWKLRSVNRRSGMTYVLKSVAGIHRQEGDSAVQTAMMVGDRPVWDTRPLPEHFLEYAADDVRHIHLLSTYLPSLAKQVSEAAVERLSAQYVEHYGVGHAVTVEADAQPAQVNTAWLERYIGPGGVCSYCGSKGHTESECFRKMNGNMRCSFCGATGHTARNCFQKHPELLKCDRCGQLGHSTGNCFRANPCKHCGGNHRSENCHYRAHSVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GN97</accession>
    <name>A0A836GN97_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphoenolpyruvate carboxykinase (ATP)</fullName>
            <ecNumber evidence="3">4.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_04258</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>oxaloacetate + ATP = phosphoenolpyruvate + ADP + CO2</text>
            <dbReference type="Rhea" id="RHEA:18617"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.49" evidence="3"/>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062182.1">
        <property type="nucleotide sequence ID" value="XM_067206245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GN97"/>
    <dbReference type="SMR" id="A0A836GN97"/>
    <dbReference type="GeneID" id="92360179"/>
    <dbReference type="KEGG" id="loi:92360179"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004612">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00484">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.449.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.8.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00453">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001272">
        <property type="entry name" value="PEP_carboxykinase_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015994">
        <property type="entry name" value="PEPCK_ATP_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00224">
        <property type="entry name" value="pckA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006820">
        <property type="entry name" value="PRK09344.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006821">
        <property type="entry name" value="PRK09344.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30031:SF0">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE (ATP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30031">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01293">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006294">
        <property type="entry name" value="PEP_crbxkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="PEP carboxykinase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53795">
        <property type="entry name" value="PEP carboxykinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00532">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5475674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="525" mass="58373" checksum="99513897314D3271" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GNL9</accession>
    <name>A0A836GNL9_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_04674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000023">
        <property type="protein sequence ID" value="KAG5478441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063102.1">
        <property type="nucleotide sequence ID" value="XM_067206655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GNL9"/>
    <dbReference type="SMR" id="A0A836GNL9"/>
    <dbReference type="GeneID" id="92360589"/>
    <dbReference type="KEGG" id="loi:92360589"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5478441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="367" mass="39912" checksum="64DFB708047D63B4" modified="2021-09-29" version="1">MSMPLVPVMRPAVASAASVYGNNRIGMQTSVLPTGTTLFLREEGSRAFVPVYHQSSVTLRDLAEEFNISSVLECDAHGNVQPRAVALDSPSDVLHSGRHYIARRDARAEAGNSYVTFRGKILVKEYELEHPTPPASRNIKTVTIAGDGVGSASHAHETHTLSAATPFPEKRSIRQSMESSEESGEVSGLAACTPAPLRDHSEENRLTISRALALSSERKRPREDTSRTGAEGAAMDEESQQRSQAQRAEESQLSSATQPGKESVLQNRTNATCVPQRLSGKTSDVQSSAGASKRDRSSCEPAPRSLRFIPFSETASDGSETYVTLEDLQRLCQEVDTQEEAFQKRHKAATDILESARRVLFTTGEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GP11</accession>
    <name>A0A836GP11_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_04593</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">LSCM4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPCS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062785.1">
        <property type="nucleotide sequence ID" value="XM_067206576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GP11"/>
    <dbReference type="GeneID" id="92360510"/>
    <dbReference type="KEGG" id="loi:92360510"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009542">
        <property type="entry name" value="Spc1/SPCS1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06645">
        <property type="entry name" value="SPC12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5477374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="145" mass="15871" checksum="79CF8DEA98FB69A5" modified="2021-09-29" version="1">MEAAGTPAAHPAASAPRQVHPAARWVAALFSPMSLRDQEYCANMLQRILWGSLMISFPIAYWTGRVRVTVIGLCAAMVVCIVLFVPNWYQNPDPALTYADDTEVYNYYQQYEAAKKAAREASVAPKKAADASTTSSGEKPRQATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GQE6</accession>
    <name>A0A836GQE6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_01152</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="4"/>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5468063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059865.1">
        <property type="nucleotide sequence ID" value="XM_067203215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GQE6"/>
    <dbReference type="SMR" id="A0A836GQE6"/>
    <dbReference type="GeneID" id="92357149"/>
    <dbReference type="KEGG" id="loi:92357149"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="5">
        <location>
            <begin position="111"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5468063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="309" mass="35574" checksum="EE80ACED5FCAA169" modified="2021-09-29" version="1">MDLDAWEEKLRHVQPLETKEMQLLLRTAVNLLIEESNVQGVHLPVTICGDIHGQFLDLLRLFEVAGEIRRETGSMNYVFLGDLVDRGRNSVEVLTFLLILKLKYPHKITLIRGNHETRQVTTMYGFYDECAEKYGTVEIWKLCTEVFDCMPIAALIEGKSLCLHGGLSPEIRAVDQIRLLNRRQEIPNEGPFSDLVWSDPENVDGWVVSQRGAGFLFGASVTQEFMHRNRLNLVARAHQLVHEGFKYHFDEDYICTVWSAPNYCYRCGNLASVLRIYEDDSREFVVFKEVETQVTASDEHRAKEPGYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GTW9</accession>
    <name>A0A836GTW9_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_03334</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060897.1">
        <property type="nucleotide sequence ID" value="XM_067205345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GTW9"/>
    <dbReference type="GeneID" id="92359279"/>
    <dbReference type="KEGG" id="loi:92359279"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050693">
        <property type="entry name" value="Hsp70_NEF-Inhibitors"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316:SF18">
        <property type="entry name" value="HSP70-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316">
        <property type="entry name" value="PROTEIN FOLDING REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5471780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="461" mass="49042" checksum="9A77720785E55862" modified="2021-09-29" version="1">MSSDSAVNAALLNLCAQLQDSGARTTTREAPAALHTDGGCGEVMPLSSTSAAACPAAPEAGASAAVAELARPSSDYEWLRNALASVEAPEKRIKQLLFNMENQTAEGSPGPLTQEERVESLEEMAEMVEDVNWAAEFALMQGPQRLLQVLRRERAAHPLLSISTADSDAHVEAAEGTDTAEGEAPRCTRSANASSTVPLFAGFAMVVAHSAQLNEPVQAAYQVARWEDIILPLIGDCIKALQALVLLVSGGEAVDRGVGSAESSISAAEIMPLLRLLGAMLHACSCLCRDCAPNTIVFIQSNGLAVVVEALRLTQTLPESLLMSEAMAGRAPVAVTNIALGAASEEVADTDAPLLRATHKVAARAFFFVAYLASTGVSSEDIIRLTCLHAESRSSDETLQKAAARALLALLEKSPQSIKEFAHTLMPRRMKEWRTHLQRVEGDGAMEDERRQFVDAIDQMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GU09</accession>
    <name>A0A836GU09_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_03398</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060957.1">
        <property type="nucleotide sequence ID" value="XM_067205405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GU09"/>
    <dbReference type="SMR" id="A0A836GU09"/>
    <dbReference type="GeneID" id="92359339"/>
    <dbReference type="KEGG" id="loi:92359339"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19138">
        <property type="entry name" value="AKR_YeaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43638:SF3">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43638">
        <property type="entry name" value="OXIDOREDUCTASE, ALDO/KETO REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="18"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="3">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5471840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="286" mass="30861" checksum="EEAC5B9BF22F7856" modified="2021-09-29" version="1">MAARRAVRLPDGATAPALGQGVWMMGDIPEKRASELAALRAGMAAGMTLIDTAEMYGNGRSERLVAEAIKETPREQLFIVSKVLPQNASRAKIFQSCDASLQNIGTDYLDLYLLHWRGGVPLSETVTCMEELVRSGKIRRWGVSNFDVDDMEELWRVPGGDHCAANQVLYHLGSRGIEHDLIPWLTEHNVPVMAYCPIAQAGELNSELYKSAVVQGVAARHSATVTQVLLAFVLSSGRVIAIPRSSTPAHTTENAAAAGIVLTEADIAELNAAFPAPTHKVPLDIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GU64</accession>
    <name>A0A836GU64_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial ribosomal protein S18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_00241</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058431.1">
        <property type="nucleotide sequence ID" value="XM_067202330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GU64"/>
    <dbReference type="SMR" id="A0A836GU64"/>
    <dbReference type="GeneID" id="92356264"/>
    <dbReference type="KEGG" id="loi:92356264"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_bS18_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="Ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5464800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="325" mass="37582" checksum="C450D34A08E603FC" modified="2021-09-29" version="1">MNRIPAAARNAPVYATAMSQFAVCRLPWSEYLGLLTKADAQPLHTTPQEKPAYRGRKRGREGWLFGQQVQLHYHRFPDEQLFTNLTRWRMGDTVGDVAIQQFRNAQPFDMEDKDPQGFQRPAPDVYMKLNYKNPATISRFLTRTGHMYPQDIMPLNPEAVAKLRVAKAQAIRIGLYPRFGNPFWFRSQRFRPKAYQENYDPTTYSTKHTMEHFAYNWVQTDRIRQYFKGLEELHQSRRATASSSGGGVTSEQKQQNQLYALDNMSIEMHRNAPSYKADVERSIKNPTVPGLMSTKGMKKKFHNLYSSTSTKRMGFTNPTLGIKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GUD0</accession>
    <name>A0A836GUD0_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000020">
        <property type="protein sequence ID" value="KAG5480329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063660.1">
        <property type="nucleotide sequence ID" value="XM_067208020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GUD0"/>
    <dbReference type="GeneID" id="92361954"/>
    <dbReference type="KEGG" id="loi:92361954"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5480329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="72" mass="7626" checksum="8D4849F69E3C7476" modified="2021-09-29" version="1">MGMQRPRITHSLFEEDSAVCDAHEGGGDVSSQIGRMQLALSGSARGEGEWEGRGVGGGGSRPRLLRVQNAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GUD3</accession>
    <name>A0A836GUD3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_00368</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Putative oxidoreductase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058551.1">
        <property type="nucleotide sequence ID" value="XM_067202450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GUD3"/>
    <dbReference type="SMR" id="A0A836GUD3"/>
    <dbReference type="GeneID" id="92356384"/>
    <dbReference type="KEGG" id="loi:92356384"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="34"/>
            <end position="230"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00037096"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5464920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="306" mass="33136" checksum="6D4327F5596E12C1" modified="2021-09-29" version="1">MSRIAYAALLSLALAFLSRHVYRRVRRQQLQAGAVALITGGGSGLGLELARIFAAAHCEIVLVGRNEAALRTAAQVCREAGAPRVEYIQADLSKVDGTDHVRREYARRYSGTGRGVVPPLKYLVLNAGAGAIAPFSSESNFEQICHDVMSINYFANVRLLQVFLPQLTQNHSPSSPSRIVVMSSLAGVLPSVLRSAYTASKHAIQGFMNALRGETAVHITLCCPGYVDTDFHSRALKNDGKALGGNQRRGVSPSVCARQCMDGVLCGDPEVIMTTAGLLAYHLRPFLTRIVDELAKRKSLKSLEHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GV07</accession>
    <name>A0A836GV07_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_03054</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060624.1">
        <property type="nucleotide sequence ID" value="XM_067205072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GV07"/>
    <dbReference type="GeneID" id="92359006"/>
    <dbReference type="KEGG" id="loi:92359006"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
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    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
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        <property type="entry name" value="PH_domain"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="113"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5470358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="284" mass="30227" checksum="8AC129FECFD53C47" modified="2021-09-29" version="1">MLTSLESRTEKLLLAAREEACLLAAQLEKSRTARGTFRCVSSGARHAASAAAPTVGTSPPSPTREGSASREASAASRFSRGSSAIDVSGRTRSPSAAPPPASPPRVVVLTAATQKKGTLLHLVRSSGLFGGGSRSFVPHYIVVSGGAGISWYASEAEYHQHPSRPLGHANFWIETFNSRGSRFKKAAVCWPLILPGDCPEARDASKTYFAVDYYTPDGAREQMVLAASSPAERDAWVQFLTKYIDLYLAPRAESEELQHIPRGAAVPLHRSGVIEGEAPGGNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GWS1</accession>
    <name>A0A836GWS1_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_01370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059115.1">
        <property type="nucleotide sequence ID" value="XM_067203424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GWS1"/>
    <dbReference type="SMR" id="A0A836GWS1"/>
    <dbReference type="GeneID" id="92357358"/>
    <dbReference type="KEGG" id="loi:92357358"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="378"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="280"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="463"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="506"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="574"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5466225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="624" mass="67120" checksum="C65C00A41537FDBA" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GXB6</accession>
    <name>A0A836GXB6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DM10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_04159</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062085.1">
        <property type="nucleotide sequence ID" value="XM_067206148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GXB6"/>
    <dbReference type="SMR" id="A0A836GXB6"/>
    <dbReference type="GeneID" id="92360082"/>
    <dbReference type="KEGG" id="loi:92360082"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043014">
        <property type="term" value="F:alpha-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060285">
        <property type="term" value="P:cilium-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.170:FF:000002">
        <property type="entry name" value="EF-hand domain (C-terminal) containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.170:FF:000007">
        <property type="entry name" value="EF-Hand domain-Containing protein 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.170">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006602">
        <property type="entry name" value="DM10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040193">
        <property type="entry name" value="EFHC1/EFHC2/EFHB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12086:SF15">
        <property type="entry name" value="DM10 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12086">
        <property type="entry name" value="EF-HAND DOMAIN C-TERMINAL CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06565">
        <property type="entry name" value="DM10_dom"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00676">
        <property type="entry name" value="DM10"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
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    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0282">Flagellum</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DM10" evidence="8">
        <location>
            <begin position="91"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="DM10" evidence="8">
        <location>
            <begin position="251"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="DM10" evidence="8">
        <location>
            <begin position="421"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5475577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="760" mass="85736" checksum="81713847108B7C67" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="4">C2 domain-containing protein</fullName>
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        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060720.1">
        <property type="nucleotide sequence ID" value="XM_067205168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GXK8"/>
    <dbReference type="GeneID" id="92359102"/>
    <dbReference type="KEGG" id="loi:92359102"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="212"/>
        </location>
    </feature>
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        <location>
            <begin position="446"/>
            <end position="470"/>
        </location>
    </feature>
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            <begin position="104"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5471603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="470" mass="48450" checksum="CC2555065C26F455" modified="2021-09-29" version="1">MADGMGEAYMDIRVCNLVLQQGTMPKGLNSGFHIDGLYVVLRCHEEVRRTSCLWPSAYAASAKESHSAAAQQAVGAGAYEEPDEEDMVWNEMFRFVVPSAVPSTAPAATPLSPQSLPAAHGGDSRSGFGAPYTRPLCQSGGSCSAGGGSCDIPGGAAPSMFTADGACGFGASYKPPHSSHALSSPSFQSAAAQQQSSGPHNSSRPTEAKATNSPLFYPTVELELWRSTPPSENLLGRYTYHVPMELMQAGYDLSSLDSVVERVVLLHTKEAPSIMGNFYGWSGHRLSLRLRVQAVGLAPLVPAQLPQHGSDTMMTAANMAGSGVYPVSSSAITSGAPLAGAPPFTAAGVYGSPLGTLNPVLASLLAPLGVSTGVSAAGNVAPGETMSMPGGMGGDILHRAPRPPLFWMFPPASGATAGMGGRALPPHLPGVSPATLQSSAQGILGDGDLAWQSSTTQPTVYPPHGLPQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GY28</accession>
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        </submittedName>
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        <name evidence="2" type="ORF">LSCM4_03401</name>
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        <name type="scientific">Leishmania orientalis</name>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    <dbReference type="AlphaFoldDB" id="A0A836GY28"/>
    <dbReference type="GeneID" id="92359342"/>
    <dbReference type="KEGG" id="loi:92359342"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
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            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5471843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="247" mass="27283" checksum="11568B89D539264B" modified="2021-09-29" version="1">MPPASNTPAREKEQLHRKFSAAANALADLYRESSNSYEAGYRDALLFVQRYLQSSSPVTEHELAPSSAFSICETVNAQHMAQFLQNTIATRRERMAAVRGIHSFRRRRRESERGGSGVGDSIMAGEHGDAMESDEEEDGEERCLTPHPSPAANTEPPTGLAALVASRVEGTATPDFSPAAFVVVNSMSPALNREMEHVRHLGHPVAERLPYQPRRQRPRMERTQSHCSVSFADGHPLSAQLRIGRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GY39</accession>
    <name>A0A836GY39_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067205423.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92359357"/>
    <dbReference type="KEGG" id="loi:92359357"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
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            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="1029"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="1144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1382"/>
            <end position="1415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1427"/>
            <end position="1448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="731"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5471858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1483" mass="155673" checksum="3CD1A0FF6CEF63C8" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GY71</accession>
    <name>A0A836GY71_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2HC/C3H-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_07009</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000018">
        <property type="protein sequence ID" value="KAG5481299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063978.1">
        <property type="nucleotide sequence ID" value="XM_067208915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GY71"/>
    <dbReference type="GeneID" id="92362849"/>
    <dbReference type="KEGG" id="loi:92362849"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001258">
        <property type="entry name" value="Uncharacterized protein TCIL3000_10_13860"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025874">
        <property type="entry name" value="DZR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026319">
        <property type="entry name" value="ZC2HC1A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049899">
        <property type="entry name" value="Znf_C2HC_C3H"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13555">
        <property type="entry name" value="C2H2 ZINC FINGER CGI-62-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13555:SF65">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12773">
        <property type="entry name" value="DZR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13913">
        <property type="entry name" value="zf-C2HC_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52027">
        <property type="entry name" value="ZF_C2HC_C3H"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2HC/C3H-type" evidence="7">
        <location>
            <begin position="89"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="C2HC/C3H-type" evidence="7">
        <location>
            <begin position="232"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="C2HC/C3H-type" evidence="7">
        <location>
            <begin position="578"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="C2HC/C3H-type" evidence="7">
        <location>
            <begin position="680"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="113"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="295"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="526"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="616"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="306"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="544"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5481299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="717" mass="77362" checksum="5148C3DD101F38C1" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GYF7</accession>
    <name>A0A836GYF7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_01710</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPR family. P subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059448.1">
        <property type="nucleotide sequence ID" value="XM_067203757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GYF7"/>
    <dbReference type="GeneID" id="92357691"/>
    <dbReference type="KEGG" id="loi:92357691"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031595">
        <property type="entry name" value="PRORP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13547">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13547:SF1">
        <property type="entry name" value="MITOCHONDRIAL RIBONUCLEASE P CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16953">
        <property type="entry name" value="PRORP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PRORP" evidence="9">
        <location>
            <begin position="402"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5466558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="583" mass="65580" checksum="F0C79AF2063225DB" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GZ72</accession>
    <name>A0A836GZ72_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA uridylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_03818</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>RNA(n) + UTP = RNA(n)-3'-uridine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14785"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17348"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173116"/>
            <dbReference type="EC" id="2.7.7.52"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.52" evidence="3"/>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061751.1">
        <property type="nucleotide sequence ID" value="XM_067205814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GZ72"/>
    <dbReference type="GeneID" id="92359748"/>
    <dbReference type="KEGG" id="loi:92359748"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050265">
        <property type="term" value="F:RNA uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.50:FF:000003">
        <property type="entry name" value="RNA polymerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF36">
        <property type="entry name" value="PAP-ASSOCIATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAP-associated" evidence="9">
        <location>
            <begin position="344"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="485"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="488"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="499"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5474645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="508" mass="56702" checksum="F0B320DFC9141C0F" modified="2021-09-29" version="1">MRRILAPWCLKSTRALHIPWTSKLPLPSDPRWHGLGKAIVDLARSCDTGKAAFEECCVAREQLEFVVQSMGYDMSIYIFGGLVTTGLFEVGGDVDFVGILDIEPGFAEAGEILRRASGALRRLGLRSRVYPKARVPVIKADRVSRSLPGSPFHSLSCDGIFQFSRQVNTGEAESFTSRVKSNYNATSVEWNSSYQFATVQFANTSSLVYGLANLRVHNEVEISLRLPVDARYGPEVYRFPFDFCLSPTGLRSSHLLGEALAEYPYSRHLLLVLKKWGRASGIINSIDGLLASYALTVMVVHFLSLVQAIPKVTAAKLNEGPKVLSPNPEYRPLEEAPLGAMGEVGYLLAAFLEYFGCAFDYEKMVVCTTNMGLTKAMMEWDRDTGAIGKPPFFHFAIKDPYGLDNIARNLDLESTAYVQKAHHLAVKTVMEELNDPTFLISELTKDPRKPLRVVRSLSDRGIRSESIPPDQLEARHALSRLQFQQRKRSMEDFGERAVKNKKKSEHSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GZG4</accession>
    <name>A0A836GZG4_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_07224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG5483014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
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    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="EMBL" id="KAG5483014.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="601" mass="63973" checksum="5EFA8E24E6BC2CFB" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GZK8</accession>
    <name>A0A836GZK8_9TRYP</name>
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        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor</fullName>
        </recommendedName>
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        <name evidence="3" type="ORF">LSCM4_04017</name>
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        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061946.1">
        <property type="nucleotide sequence ID" value="XM_067206009.1"/>
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    <dbReference type="KEGG" id="loi:92359943"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
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    </dbReference>
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        <property type="term" value="F:translation initiation factor activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Eukaryotic translation initiation factor, putative"/>
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    </dbReference>
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        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
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    </dbReference>
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        <property type="entry name" value="TIF_eIF_4E"/>
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        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
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    </dbReference>
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        <property type="entry name" value="TRANSLATION INITIATION FACTOR 4E, PUTATIVE-RELATED"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
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        </location>
    </feature>
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        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5474840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="37611" checksum="805772999839EB8D" modified="2021-09-29" version="1">MNPSAASFVPQKSDAKGKSSLPPAASVAKPPPQLATKLSAAAPPFVPGGPKQVPAASTHVDPKANAEDGKSTTPPPIEPPAGSLPDSAAGAAAAADAGNKGADENEDSQLDWLPEAQPVDWSESKLPKLFGCHNTAAKATSSAIPLHASWDLYADDHQGSSNTASNSSPDSTMSFEPIFVSNVGDVESFWRLWRYLPAPSALPTVFTYSWFRKDIKPEWEHPRNKKGGTISIVVFDRDRSGLSDKQVLDDVFMAMLVGAVGESFHECSTTLNGIMLKVRSNKPVTLQLWTAHSEVGKLKAFANSVRDALGKIMGAKTLQKLEYYSHHQKQAATNSLAARMKGKTKISPDHTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H0L2</accession>
    <name>A0A836H0L2_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_04475</name>
    </gene>
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        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067206459.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92360393"/>
    <dbReference type="KEGG" id="loi:92360393"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032512049" evidence="2">
        <location>
            <begin position="26"/>
            <end position="2051"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1093"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1592"/>
            <end position="1612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1600"/>
            <end position="1612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5477257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="2051" mass="218712" checksum="3B7E5E6005E4FAC9" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H205</accession>
    <name>A0A836H205_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">40S ribosomal protein S16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_05070</name>
        <name evidence="6" type="ORF">LSCM4_05071</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">LSCM4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062347.1">
        <property type="nucleotide sequence ID" value="XM_067207044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H205"/>
    <dbReference type="SMR" id="A0A836H205"/>
    <dbReference type="GeneID" id="92360978"/>
    <dbReference type="KEGG" id="loi:92360978"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000093">
        <property type="entry name" value="40S ribosomal protein S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_uS9_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF16">
        <property type="entry name" value="RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5476114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5476115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="149" mass="16704" checksum="56B20805633364B2" modified="2021-09-29" version="1">MPADKNYALKQVQTFGKKKTAIAVATVTKAAQCSIKVNGVPLQQILPDTLRAKIMEAITVVGSKYYSRLRIDVTVHGGGQVSQAYAARQAIAKGLVAFFQKYHNEVEKAALKDKFLAYDKFLLIADPRRCEPKKWGRHSARTRFTKSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H283</accession>
    <name>A0A836H283_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062468.1">
        <property type="nucleotide sequence ID" value="XM_067207165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H283"/>
    <dbReference type="GeneID" id="92361099"/>
    <dbReference type="KEGG" id="loi:92361099"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5476235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="313" mass="32415" checksum="E977F2E5382918F7" modified="2021-09-29" version="1">MGGESSKHSNSAANARSRERKRGALPAALTGGDCRAVPLSDRTTRFGPSYGEVPDYIPPSPVRCVASPIPPSGSLDPSVTWILDTEAVLITEWNRDLQGVCTPRTGALGALRGREAAGADSKLLGPKTLPESAASTVASITPGLTSSSTCPPLSGPPSPTHLQSSSGVSLTCDSVAVTTGRSTGMTLRVPTTWTQSKLSCAGASSKAVASSTSSEASPCDPAGGASSIVVSVLPVGIDYFRALQSRWLALAHRSLPPPADEEDLNDSVILEAVSEANGDVLSPPVPLGYMIDLFVPQWRSEGLYEAAQDYQTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H3G6</accession>
    <name>A0A836H3G6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cation efflux family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_02865</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060437.1">
        <property type="nucleotide sequence ID" value="XM_067204885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H3G6"/>
    <dbReference type="GeneID" id="92358819"/>
    <dbReference type="KEGG" id="loi:92358819"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="389"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="496"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="196"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="390"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5470171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="631" mass="67111" checksum="68BE2557505DF752" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H412</accession>
    <name>A0A836H412_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">leucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Leucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LSCM4_07941</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">LSCM4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Leu) + L-leucine + ATP = L-leucyl-tRNA(Leu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="2"/>
    <dbReference type="EMBL" id="JAFHLR010000013">
        <property type="protein sequence ID" value="KAG5484374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064867.1">
        <property type="nucleotide sequence ID" value="XM_067209817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H412"/>
    <dbReference type="SMR" id="A0A836H412"/>
    <dbReference type="GeneID" id="92363751"/>
    <dbReference type="KEGG" id="loi:92363751"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000001">
        <property type="entry name" value="Leucine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000075">
        <property type="entry name" value="Putative leucyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004493">
        <property type="entry name" value="Leu-tRNA-synth_Ia_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055416">
        <property type="entry name" value="RBD_LARS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00395">
        <property type="entry name" value="leuS_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794:SF1">
        <property type="entry name" value="LEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
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                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
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                <person name="Bates M.D."/>
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                <person name="Bates M.D."/>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060892.1">
        <property type="nucleotide sequence ID" value="XM_067205340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H7E8"/>
    <dbReference type="SMR" id="A0A836H7E8"/>
    <dbReference type="GeneID" id="92359274"/>
    <dbReference type="KEGG" id="loi:92359274"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5471775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="480" mass="52238" checksum="9C2BBD9B6B29218D" modified="2021-09-29" version="1">MGITCARDEGVAAPSSVTHFDPRRRGRHVRKTRRRHNSKAASVGHTSVMYSRADACTGCEDLSEVLCAVGPVTVPIAQPMKGKPLQMSAEKPSPKPTYRRDSSVQATAPITGTPSARRYPIYRISDDENTAGYAVMPFKSTYCLQHTTDVEPDSFRAMLTRSHAATAKHPSAPTAASNPKGDDGGKKRDATSENAALRSELAVASRALSRPSLGGGLRRCFSCGIISDSDDDGVSRQADKVSFTSILQSGLVLQPESPPDSVSGEEASSIFAKTTNGTETDESSSTALTSQTTLSRRHTFGVMMPTGYSQVVEHAEDGGAWESAAASFRTSPAARHSWRKQKSTVIASSSTEKEEKRAVLGALDRYHYSSYLNRHRQRVKGTAAVPPGAPSRYRSKVGKQWPQPLMEGPKSNLSRSRPFNVEATLGCSVRSARFVPSPDWERVDVMEKEQLRLARSLKAYQKRLAEWERAQVAHLQTLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H7J6</accession>
    <name>A0A836H7J6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">rRNA methyltransferase 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_07748</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000006">
        <property type="protein sequence ID" value="KAG5487259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065756.1">
        <property type="nucleotide sequence ID" value="XM_067209626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H7J6"/>
    <dbReference type="GeneID" id="92363560"/>
    <dbReference type="KEGG" id="loi:92363560"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047182">
        <property type="entry name" value="MRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46103">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46103:SF1">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="RNA 2-O ribose methyltransferase substrate binding" evidence="9">
        <location>
            <begin position="180"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA/rRNA methyltransferase SpoU type" evidence="8">
        <location>
            <begin position="272"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="55"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="132"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5487259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="563" mass="60447" checksum="7C5768A896E21781" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H7P9</accession>
    <name>A0A836H7P9_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_03162</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060730.1">
        <property type="nucleotide sequence ID" value="XM_067205178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H7P9"/>
    <dbReference type="GeneID" id="92359112"/>
    <dbReference type="KEGG" id="loi:92359112"/>
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        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="451"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="479"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="523"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="621"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5471613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="654" mass="72449" checksum="A9103C911F54B78A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H802</accession>
    <name>A0A836H802_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060880.1">
        <property type="nucleotide sequence ID" value="XM_067205328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H802"/>
    <dbReference type="GeneID" id="92359262"/>
    <dbReference type="KEGG" id="loi:92359262"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="626"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="757"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="969"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="303"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="663"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="684"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="764"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5471763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1055" mass="110575" checksum="C085AB1A885FF20A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name evidence="2" type="ORF">LSCM4_04491</name>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG5477273.1"/>
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    </dbReference>
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    <dbReference type="SMR" id="A0A836H981"/>
    <dbReference type="GeneID" id="92360409"/>
    <dbReference type="KEGG" id="loi:92360409"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="161"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5477273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="236" mass="26411" checksum="BE30609C9FAE5419" modified="2021-09-29" version="1">MRATRRWCSRGGLGGICACTTPRLQHFTSLHDPADSVAELRRKLQLQLYQRMPRMQTVETENRLIAQLSRSALAEERAEALERGEAMWTELHDTESSIPFGSRTAMKVTLCSLLRRCALVSKNRELAETWTVRFAERAATLSPAAFMEQTSTVGKVPGWREARAQARPGTGIDADDLEADAREEAEAAAKERAAEEKAGKSDPSPFEQYRQKKMLEHPTVELAFHRRAGPGPRYTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HAY5</accession>
    <name>A0A836HAY5_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05528</name>
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    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Trypanosomatida</taxon>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5478128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067207467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HAY5"/>
    <dbReference type="GeneID" id="92361401"/>
    <dbReference type="KEGG" id="loi:92361401"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="213"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5478128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="257" mass="31023" checksum="5C8DDA6CB2E24A8A" modified="2021-09-29" version="1">MEAWSANEGPRRVPLITRADLERREAAEDHNALLLEQWASYASRKGYPDSEERTKWMTETWEEFEKRKERQKVYLERYDLRFQQKAAQLVETQKLSERKSAACVEKVMTLEAARQSALLRSRHFLFVNYYDYQQFLFYNMRAFVEHEENLLRRKLVETEDDLMCLLATQCHLSSRLHAARENERIEQEAAAERLRELQYQQKLEEERILKAQQAAQEREAAQAEKEHAEMEKRLERKRRDDERRAKARAEREQRRAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HBB7</accession>
    <name>A0A836HBB7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fungal lipase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Euglenozoa</taxon>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061566.1">
        <property type="nucleotide sequence ID" value="XM_067205629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HBB7"/>
    <dbReference type="GeneID" id="92359563"/>
    <dbReference type="KEGG" id="loi:92359563"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5473563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="565" mass="61765" checksum="26B27CDF98A16506" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HBE7</accession>
    <name>A0A836HBE7_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03678</name>
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    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Leishmania</taxon>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061611.1">
        <property type="nucleotide sequence ID" value="XM_067205674.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="92359608"/>
    <dbReference type="KEGG" id="loi:92359608"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5473608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="383" mass="41734" checksum="B3AB949F015F19A6" modified="2021-09-29" version="1">MDRMNLHQTSRGIQELLYTLGTSLERFKGTNGLQHLVTTSKLSLLSLFGVFERTKDETYQKRATAVSETRRCLLRLVDDFDEVAGSTERLARKIDRLVGTLEQFHRCCDMEIDDRLSADDPGVQQLGQCFRQIREANSQMKGSLDDFSASRVTCTDLTRSVIVEIERVGAETSCDVAAALAAFDDQRRRVQMKENEVAHAMSRATSGEDPAVRFAEFNYAKELEALDSLGRKYIDSLGNAMTATHFALEQSSMTGWASSNIFFAQLGQLLSEISASGKAIAASLLSIKNAQKVSHQLTEEKQRILQEQRATANAPAAATSAATNLLDEGAGVLPGASPVCLNANGSLLSSPLADSSQAKPPIQASSSTEGPGRRFVDLDDLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HC76</accession>
    <name>A0A836HC76_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_07167</name>
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    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
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        <lineage>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000018">
        <property type="protein sequence ID" value="KAG5481455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064134.1">
        <property type="nucleotide sequence ID" value="XM_067209071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HC76"/>
    <dbReference type="SMR" id="A0A836HC76"/>
    <dbReference type="GeneID" id="92363005"/>
    <dbReference type="KEGG" id="loi:92363005"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5481455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="564" mass="61354" checksum="8BD6EAE8807458DB" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HDG2</accession>
    <name>A0A836HDG2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase kappa</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LSCM4_03893</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="JAFHLR010000028">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061824.1">
        <property type="nucleotide sequence ID" value="XM_067205887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HDG2"/>
    <dbReference type="SMR" id="A0A836HDG2"/>
    <dbReference type="GeneID" id="92359821"/>
    <dbReference type="KEGG" id="loi:92359821"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:damaged DNA binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03586">
        <property type="entry name" value="PolY_Pol_IV_kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.100:FF:000004">
        <property type="entry name" value="DNA polymerase IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.60:FF:000017">
        <property type="entry name" value="Putative DNA polymerase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.810">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050116">
        <property type="entry name" value="DNA_polymerase-Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022880">
        <property type="entry name" value="DNApol_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024728">
        <property type="entry name" value="PolY_HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11076:SF33">
        <property type="entry name" value="DNA POLYMERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11076">
        <property type="entry name" value="DNA REPAIR POLYMERASE UMUC / TRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11798">
        <property type="entry name" value="IMS_HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UmuC" evidence="14">
        <location>
            <begin position="215"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="616"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
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            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022695"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG5474718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="704" mass="77124" checksum="7B925574CB499DA1" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HF87</accession>
    <name>A0A836HF87_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_07258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000015">
        <property type="protein sequence ID" value="KAG5483045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="92363092"/>
    <dbReference type="KEGG" id="loi:92363092"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5483045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="435" mass="46742" checksum="ADC89A10A66A75D1" modified="2021-09-29" version="1">MAEPSRSRAPSCEAESSNAGGRPPTSAPFRYLTASSEVTRYQHPSLRSLELLLPASLWSDSYVQERARYTLQPPDSSPISASSAGAISLLSSSHARCNTPRPTSTTAPALEEQRRPSFGGVGCHLSSSTPGKWSFMAIYRNLKRAREEADMRAKVAEVPQRVSVVDSAVEEKSVCRYPALSPLVDSLTSSSASLVGDCSVTESNDSDDHGKMDTVQGRGLSSSCSVSSAASRAESINAAAWYTTSAAGASEVDTQNTIARERQMRWCGPSVSACVAARPLTLAHAEALWVLKSVLDRVSAVHETQCPLCSPPRPPRWGRCSQPALPNRPALAHDSDARADSTGPLCPKKAYVMADDVQNAQELSADAGTLTAMEAHRQHLLQRARSLLNHHDDRLRYLSETKPKLFKETVKLHPLVCACAQLGGLPLLRALSATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HIR8</accession>
    <name>A0A836HIR8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_07663</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="6"/>
    <dbReference type="EMBL" id="JAFHLR010000012">
        <property type="protein sequence ID" value="KAG5484890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065002.1">
        <property type="nucleotide sequence ID" value="XM_067209542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HIR8"/>
    <dbReference type="SMR" id="A0A836HIR8"/>
    <dbReference type="GeneID" id="92363476"/>
    <dbReference type="KEGG" id="loi:92363476"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000127">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051134">
        <property type="entry name" value="PPP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668:SF13">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="803"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5484890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="968" mass="110184" checksum="72CB8D8CFA6A784D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HJJ4</accession>
    <name>A0A836HJJ4_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5477985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062892.1">
        <property type="nucleotide sequence ID" value="XM_067207324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HJJ4"/>
    <dbReference type="GeneID" id="92361258"/>
    <dbReference type="KEGG" id="loi:92361258"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="520"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="612"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="720"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="912"/>
            <end position="940"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="526"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="582"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="638"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="743"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="924"/>
            <end position="934"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5477985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="940" mass="99671" checksum="64B45912A7BDD999" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HJN5</accession>
    <name>A0A836HJN5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_01760</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000022">
        <property type="protein sequence ID" value="KAG5479171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063264.1">
        <property type="nucleotide sequence ID" value="XM_067203805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HJN5"/>
    <dbReference type="GeneID" id="92357739"/>
    <dbReference type="KEGG" id="loi:92357739"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37562:SF5">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37562">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="261"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="261"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="303"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="307"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="371"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="389"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5479171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="479" mass="52624" checksum="714309840AEC16EE" modified="2021-09-29" version="1">MSTHSSTNSRLKKVRCKKWDTIQIPFIDDLEALTEREIQNMPLPSGFCIRFLCHDMKHLFTVASNHVRITRGTLDYLHDYNQLGPNKSRSKLFVCSQYNKAKKCMNGYLCREVHCVLNVEDAQDALRHQVPSNATGAPNLVTLAPAEDIVAKRLNEPLVAGNSVLAVNIVENTNPLDSIGGGGATDGVASFYMPDQLVLRHTLHTRWTSTKMYPTLPSGVEFRVALPNTPTPVDAYDSSLLFVTRGAQEYFNLCKRNEQPTVTMQHCAHYSKNGICCFGEDCQFVHVVHFKFRDRADNTASDVDALSMGSSGTNSESSRHRNVRRIGATTHETPLNVSVPGKKTVDSKVSSRSSSSHREPSTPHQKALPKPTSNGLSTPSSHVFVPSTSAWPAMGAAPSSASAPRSLPPPQSQHFTPDPIIVPAIPSPSSPLMSQSYMFMQGFNGHCYIVPQSATSMPPAIQPTPSQPLYVMAMPFHKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HKV3</accession>
    <name>A0A836HKV3_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_04731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000023">
        <property type="protein sequence ID" value="KAG5478498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063159.1">
        <property type="nucleotide sequence ID" value="XM_067206712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HKV3"/>
    <dbReference type="GeneID" id="92360646"/>
    <dbReference type="KEGG" id="loi:92360646"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="646"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="873"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="648"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="873"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="943"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="963"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1052"/>
            <end position="1064"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5478498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1071" mass="109858" checksum="8E06F4F69E702808" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HLS7</accession>
    <name>A0A836HLS7_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_07412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000008">
        <property type="protein sequence ID" value="KAG5486480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065546.1">
        <property type="nucleotide sequence ID" value="XM_067209303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HLS7"/>
    <dbReference type="GeneID" id="92363237"/>
    <dbReference type="KEGG" id="loi:92363237"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5486480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="285" mass="30689" checksum="AFDC4F1E1F6FF466" modified="2021-09-29" version="1">MFAPLNCATTGLRRWVAVAAARPLSPVGATAQRPASSTPFAAALSMTKRFAATTSANAGARGARNGGGPGFFGAYRAFRQERNAGRGRQYMVLSMYLDRLPPGLRELLLWSPLLALLHFVCHQARAYYLEEEEPWYYVMLPRRWRYRGDGEGGGAAVHVSSLLQRAPPSSKPTTSVAADVDCPSATYAFLNVRRRGESTATSSATTYAFAASDVQDAAPLVGSPPVASFHKVRVRHAHTDQRAPPATTPPTPSLEEAYRNGVWGAPLVVIRDPATQRVIGYTTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HLX2</accession>
    <name>A0A836HLX2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_01804</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000022">
        <property type="protein sequence ID" value="KAG5479215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063308.1">
        <property type="nucleotide sequence ID" value="XM_067203849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HLX2"/>
    <dbReference type="SMR" id="A0A836HLX2"/>
    <dbReference type="GeneID" id="92357783"/>
    <dbReference type="KEGG" id="loi:92357783"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000090">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2-17 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="89"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5479215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="259" mass="27909" checksum="52A8E6719A75FDD3" modified="2021-09-29" version="1">MQAAPLSTRNVPGDGDDIPQPAPAHGATTIIDTNEPEAAPAQPAVGETTAMEQDGFQPPSAEALAARQSRNSVAAEKMGGGQQLKDHKTAQRRLMQDYRAFQKNMAEGTSSNITALPVDGDFFHWHAVISGPCDTPWEGGLFKLDLTFGDDYPFSPPKVRFLTKDVFHPNVYVDGNICMDTLKSSWQSSLNLEALLISIQSLLSDPNPLSAANGAAARLLTENRSAYDERIRALVEESLEQSFSMDDDSDDAEADAGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HNA2</accession>
    <name>A0A836HNA2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phosphotransferase</fullName>
            <ecNumber evidence="11">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LSCM4_05734</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-fructose + ATP = D-fructose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:16126"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22740"/>
            <dbReference type="ChEBI" id="CHEBI:4194"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:229467"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:22741"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the hexokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="11"/>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063439.1">
        <property type="nucleotide sequence ID" value="XM_067207666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HNA2"/>
    <dbReference type="SMR" id="A0A836HNA2"/>
    <dbReference type="GeneID" id="92361600"/>
    <dbReference type="KEGG" id="loi:92361600"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000156">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.367.20:FF:000010">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019807">
        <property type="entry name" value="Hexokinase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF16">
        <property type="entry name" value="HEXOKINASE TYPE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00378">
        <property type="entry name" value="HEXOKINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0324">Glycolysis</keyword>
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    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="12">
        <location>
            <begin position="31"/>
            <end position="222"/>
        </location>
    </feature>
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        <location>
            <begin position="231"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00044613"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047905"/>
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        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5479728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="471" mass="51827" checksum="995EB38D239A6093" modified="2021-09-29" version="1">MASRVNNLMNHIAIRDSDSDEMRCIKQRLALASLSTQFTLSSEKMKQLTMYMIHEMVEGLEGRPSTVRMLPSFVYTSDPAKATGVYYALDLGGTNFRVLRVSLRGGKVEDRIDSKFVIPKSALVGDATDLFDFIAQSVKKMMTEHAPEDMEKRVPLGFTFSFPVDQKAVNKGLLIKWTKGFSTKNVEGNDVVELLQASLRRVRVNVNIVALCNDTVGTLVARYFVDTDVQVGVIIGTGSNACYFERASAVTKDPAVSARGNAVTPINMECGNFDSKYKYALPITVYDEEMDAITPNHEHQRQEKLVSGMYLGEIARRIIVHLAQLGCLPRELVDGLCKPWMFESKHMGMIAADQMPGLQFTRELMKRVAGVDVANMSDLHVLRETCCLVRNRAAQQGAVFTAAPMLKTHTQGLATVAVDGSVYEKVPSFQRLYQECITGILGSSSNVNVVLQKDGSGVGAAMICALAANQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HPL3</accession>
    <name>A0A836HPL3_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_08249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000003">
        <property type="protein sequence ID" value="KAG5488025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066152.1">
        <property type="nucleotide sequence ID" value="XM_067210119.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92364053"/>
    <dbReference type="KEGG" id="loi:92364053"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="TruD, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001656">
        <property type="entry name" value="PsdUridine_synth_TruD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042214">
        <property type="entry name" value="TruD_catalytic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326:SF23">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="312"/>
        </location>
    </feature>
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        <location>
            <begin position="431"/>
            <end position="462"/>
        </location>
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        <location>
            <begin position="931"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1165"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1597"/>
            <end position="1619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1972"/>
            <end position="2035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="934"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1173"/>
            <end position="1192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5488025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="2175" mass="232837" checksum="166985C59E068406" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HPU5</accession>
    <name>A0A836HPU5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Exportin-T</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 10">Exportin(tRNA)</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 10">tRNA exportin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LSCM4_08137</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <text evidence="10">Shuttles between the nucleus and the cytoplasm.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the exportin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000002">
        <property type="protein sequence ID" value="KAG5488160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066208.1">
        <property type="nucleotide sequence ID" value="XM_067210010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HPU5"/>
    <dbReference type="GeneID" id="92363944"/>
    <dbReference type="KEGG" id="loi:92363944"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071528">
        <property type="term" value="P:tRNA re-export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045546">
        <property type="entry name" value="Exportin-T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040017">
        <property type="entry name" value="XPOT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15952:SF11">
        <property type="entry name" value="EXPORTIN-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15952">
        <property type="entry name" value="EXPORTIN-T/LOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19282">
        <property type="entry name" value="Exportin-T"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="5 10" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Exportin-1/Importin-beta-like" evidence="12">
        <location>
            <begin position="109"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Exportin-T C-terminal" evidence="13">
        <location>
            <begin position="436"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="Exportin-T C-terminal" evidence="13">
        <location>
            <begin position="833"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="773"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="775"/>
            <end position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF19282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG5488160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1162" mass="127562" checksum="92B8B562A7D401D6" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HRH7</accession>
    <name>A0A836HRH7_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_07013</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMCO4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000018">
        <property type="protein sequence ID" value="KAG5481303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063982.1">
        <property type="nucleotide sequence ID" value="XM_067208919.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92362853"/>
    <dbReference type="KEGG" id="loi:92362853"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007941">
        <property type="entry name" value="DUF726"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920:SF3">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05277">
        <property type="entry name" value="DUF726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5481303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1502" mass="163473" checksum="3DCA228D47A20DBC" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HUC7</accession>
    <name>A0A836HUC7_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_07466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000004">
        <property type="protein sequence ID" value="KAG5487788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065985.1">
        <property type="nucleotide sequence ID" value="XM_067209353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HUC7"/>
    <dbReference type="GeneID" id="92363287"/>
    <dbReference type="KEGG" id="loi:92363287"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5487788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="158" mass="16574" checksum="64D7DB61FD64EB61" modified="2021-09-29" version="1">MPDFSQFIKYFNANLPAPTGQNGTQGGVGGKGSGGASGATETSSPASHSDTSAFTRSCDTTWRVLLPSDAAAKESGTRSSGSSSAAAAAHTSASHPSVTIGRMMVSTEDRWRIQAQMRREEARTGQARKEYNKKVTRAIKVTKGPSENAFPPGRGRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HVT4</accession>
    <name>A0A836HVT4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyrroline-5-carboxylate reductase catalytic N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_04960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000014">
        <property type="protein sequence ID" value="KAG5483805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064744.1">
        <property type="nucleotide sequence ID" value="XM_067206935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HVT4"/>
    <dbReference type="GeneID" id="92360869"/>
    <dbReference type="KEGG" id="loi:92360869"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645:SF58">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="2">
        <location>
            <begin position="142"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5483805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="577" mass="61460" checksum="32D72C729B2F34BF" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HXD9</accession>
    <name>A0A836HXD9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ras family protein-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_06778</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000009">
        <property type="protein sequence ID" value="KAG5486071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065402.1">
        <property type="nucleotide sequence ID" value="XM_067208691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HXD9"/>
    <dbReference type="SMR" id="A0A836HXD9"/>
    <dbReference type="GeneID" id="92362625"/>
    <dbReference type="KEGG" id="loi:92362625"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
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        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5486071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="29075" checksum="37C9465A06AADB47" modified="2021-09-29" version="1">MPLLLPMPSAPALPSSLDYPRIKLLVIGDVGVGKSCVIKRYCEGRFVTKYIPTIGIDFGVKKVEVNKATVLQLRRSGPSSSEATAQSGSSSDGGGCGTSSVIPTAVRVNFWDSSGDDNYLEVRNEFYEAAQGVLIMYNARNATSFASLQSWWEELSIYCQGISSAASGGGDCGSALPGAAGKRTSVSNTVTSSTAAGKAVGRTDGKAPIVVLCANKVDDTVVPGASPPQGRAVSEEQGRVWAREHSCAAYYETSASTGQNVKEVIEDLVVRTVAEFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836I153</accession>
    <name>A0A836I153_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_08133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000002">
        <property type="protein sequence ID" value="KAG5488156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066204.1">
        <property type="nucleotide sequence ID" value="XM_067210006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836I153"/>
    <dbReference type="GeneID" id="92363940"/>
    <dbReference type="KEGG" id="loi:92363940"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5488156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="304" mass="32910" checksum="B5F52713CFF42936" modified="2021-09-29" version="1">MICSFGRGGAWSRRLCRPAQYAMCRGPLLQSIWKMRSLATLSRVARSSSRRTTVGDSGLWGMHVSQSPVRVSMARSAVSSTTPHGEKRTLASQPPPPSETMTTLTSGPSPTNFALDPPFTQVKGEAELAPGPCAYTCRFCRALVFRSDKFAETSRVGRHDSGWPTFLAPSTPSALRVCTVLQKSVVARLSDTPRYRSASDIPDARTTPGRGLGIAVPHNGVAQRGLAVERDLVRRRGSRISLQETQSWREMCLRDENHRADPALVLGACSACGTPLCHITQSAARGTRYISTAACIEAQAEPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836I1U7</accession>
    <name>A0A836I1U7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_07444</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">LSCM4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000008">
        <property type="protein sequence ID" value="KAG5486508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065574.1">
        <property type="nucleotide sequence ID" value="XM_067209331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836I1U7"/>
    <dbReference type="GeneID" id="92363265"/>
    <dbReference type="KEGG" id="loi:92363265"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16536">
        <property type="entry name" value="RING-HC_RNF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039739">
        <property type="entry name" value="MAG2/RNF10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12983:SF9">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12983">
        <property type="entry name" value="RING FINGER 10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="126"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="486"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5486508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="584" mass="64449" checksum="0DBB352E199C199E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836K6T6</accession>
    <name>A0A836K6T6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Coiled-coil domain-containing protein 153</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_00714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058890.1">
        <property type="nucleotide sequence ID" value="XM_067202789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836K6T6"/>
    <dbReference type="SMR" id="A0A836K6T6"/>
    <dbReference type="GeneID" id="92356723"/>
    <dbReference type="KEGG" id="loi:92356723"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="16"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5465259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="162" mass="18549" checksum="FF03C3D89F9F9660" modified="2021-09-29" version="1">MPPKSFKKSASPEEVIAARKEKLESLSQQCAAVEKMLAISTDQGLRLNAEIAELERRIAETEVLMEQESRDLDEKVKVVSAYATNNLDQLQQRRLNMEKTANEAESENELLRAKIAELKERKEGELAQWEEKVEEQRALMNQKALDFGLQLKETLAKRYTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836K7Z2</accession>
    <name>A0A836K7Z2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Folate/biopterin transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_01716</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Folate-biopterin transporter (TC 2.A.71) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059454.1">
        <property type="nucleotide sequence ID" value="XM_067203763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836K7Z2"/>
    <dbReference type="GeneID" id="92357697"/>
    <dbReference type="KEGG" id="loi:92357697"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039309">
        <property type="entry name" value="BT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004324">
        <property type="entry name" value="FBT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00788">
        <property type="entry name" value="fbt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31585">
        <property type="entry name" value="FOLATE-BIOPTERIN TRANSPORTER 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31585:SF51">
        <property type="entry name" value="TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03092">
        <property type="entry name" value="BT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5466564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="30947" checksum="C23B0FB7933185AD" modified="2021-09-29" version="1">MSGRCRVSSTPASPPDEAVKYIHPASARLLRAAPLLGFIPVFSVTMKTFHPKFVLAICLQCLFEKGLANGLMRLSIQPMLTGRYGLTSAMYQRLSTLYTLGWAINAFITVLADTFALFGYTKRWYCVLSAVGGGVFALLYGLLPANESSAKPAAAFMFLTALFMSNIDVFAVALYSEQICRRPAAGTALVSWMWGTALVDIMISSVIQSPLSENQLTHVGVYITAAILLLSGLLFVFNLFEERRNRTARLEDAKAEFFAECEEHERRQHGSLAAEAGCTDMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KA89</accession>
    <name>A0A836KA89_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058976.1">
        <property type="nucleotide sequence ID" value="XM_067203285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KA89"/>
    <dbReference type="GeneID" id="92357219"/>
    <dbReference type="KEGG" id="loi:92357219"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5466086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="322" mass="34031" checksum="67F7306BA6C36ACB" modified="2021-09-29" version="1">MDSRHCAAEASSRTSRLAKYAALLAGLERSCRIAPATVSHSPPRTESEERCGAASPHHVSESPHSFPALSSTATDLHSTSTSFASYSPLTAQRRSERASAVARTPSTLFEVRVHRRRRKGVHGGVRQNCETFAQSVHSGCPCALWLAAFSVDAPAEVAGPYGTQYSSARAVPTPRPGDTRRARGAGSVKHGDGVAAHFALTSDDYLNHYLARYGGQFLTQSSYPNPITSASVACKEDVRNGRPVLTSELSDVSESLLSSWSFPMYSSAALPVLISTPGCSPIVAPGDGTRISSADVACRLFSPDVSPESLLGVIECASHESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KCY4</accession>
    <name>A0A836KCY4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase M16 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_02589</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060168.1">
        <property type="nucleotide sequence ID" value="XM_067204616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KCY4"/>
    <dbReference type="SMR" id="A0A836KCY4"/>
    <dbReference type="GeneID" id="92358550"/>
    <dbReference type="KEGG" id="loi:92358550"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000070">
        <property type="entry name" value="Mitochondrial processing peptidase alpha subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF49">
        <property type="entry name" value="MITOCHONDRIAL-PROCESSING PEPTIDASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="3">
        <location>
            <begin position="183"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5469191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="483" mass="52993" checksum="8FA864FB89451505" modified="2021-09-29" version="1">MFTASRLLRGIAETITRENFTISRLTNGLRIITCEDGNGITGMGLFSLNGPKFEEEGSFGASAVMESLPLRSNTCMTTETISQSLGVFGNAYKVTNNREAMSVMLMMPRYHQKEGLDVLNGMWLHPTESADEFDVAKAQTLHRSSLCSRDATSMLFELVHKAGWSGRGLGNPLSPTEEQLEQLTLEKFHAFHRRYTTPERTVLAATGVSDHTAFVQESEARLQFPAPPSSSSLSSSSEAAKTAAAATAQVHPYTGGCEYIQNTAAPESMNKFQEKNLSHMALFFKAIPMAHPDYFTFSVIQTLLGGGTSFSSGGPGKGMQTKLFREVLNREPNLHGMECITAWYSDGGLIGLYGSAPHEHVSNLLRIMIHQAASISQRITPGHLEMAKNQLSSQLILLGEGREQLLNDMGFNLLVHDYTITPQETMQGSAQVTMERLHHVCAQLLEHPVTFAVYGETKGMPDYPQLVAALKKSYSTLNNSTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KCZ5</accession>
    <name>A0A836KCZ5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">3'-nucleotidase/nuclease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_03338</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">LSCM4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclease type I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060901.1">
        <property type="nucleotide sequence ID" value="XM_067205349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KCZ5"/>
    <dbReference type="SMR" id="A0A836KCZ5"/>
    <dbReference type="GeneID" id="92359283"/>
    <dbReference type="KEGG" id="loi:92359283"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11010">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.575.10:FF:000003">
        <property type="entry name" value="Single strand-specific nuclease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.575.10">
        <property type="entry name" value="P1 Nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008947">
        <property type="entry name" value="PLipase_C/P1_nuclease_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003154">
        <property type="entry name" value="S1/P1nuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146">
        <property type="entry name" value="ENDONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146:SF10">
        <property type="entry name" value="STRAND-SPECIFIC NUCLEASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02265">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48537">
        <property type="entry name" value="Phospholipase C/P1 nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032929179" description="3'-nucleotidase/nuclease" evidence="9">
        <location>
            <begin position="28"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5471784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="379" mass="41030" checksum="24733A187CA939B9" modified="2021-09-29" version="1">MAPHVCLAPPLLLALALLSISASPVGAWWSKGHMAVALIAQRHMDASLVEKGNLAAKVLSLSGPYPRSPDMVQLGPWADDIKTVGLQTLSTWHFITTPYYPDKNFTLEFSPVQTVNVASVIPMLQSALQNAASNSEIIAQSLALLIHFVGDIHQPLHNANMFSNQYPESDLGGNAQTVAIDSTGTKMLLHAYWDSMAEGKAGEDKSRPLSKDDYKDLNEFVDYLEATYASTLKDVEKNLLNTTRISGESYDLAVKHAYPGAENGATLSAEYKTNAKSITERQVLLAGYRLAKMLNTTLKSVSTTKILEGVKDVESGVDTVNKTKINNYYEQKGLSAGVTTGVAAALFAMGMITATLVALAFRYCVEKSDRLGAYEYVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KDZ4</accession>
    <name>A0A836KDZ4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pseudouridine synthase RsuA/RluA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_02112</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061185.1">
        <property type="nucleotide sequence ID" value="XM_067204148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KDZ4"/>
    <dbReference type="GeneID" id="92358082"/>
    <dbReference type="KEGG" id="loi:92358082"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluA-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF87">
        <property type="entry name" value="RNA PSEUDOURIDYLATE SYNTHASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="4">
        <location>
            <begin position="201"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="4">
        <location>
            <begin position="274"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="160"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="189"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5472789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="532" mass="58319" checksum="8EA3F1EA9FD536BB" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KEQ3</accession>
    <name>A0A836KEQ3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine/threonine-protein kinase TOR</fullName>
            <ecNumber evidence="9">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LSCM4_01169</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="9"/>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5468080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059882.1">
        <property type="nucleotide sequence ID" value="XM_067203232.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836KEQ3"/>
    <dbReference type="GeneID" id="92357166"/>
    <dbReference type="KEGG" id="loi:92357166"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016242">
        <property type="term" value="P:negative regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05169">
        <property type="entry name" value="PIKKc_TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000039">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000022">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.150">
        <property type="entry name" value="FKBP12-rapamycin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009076">
        <property type="entry name" value="FRB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036738">
        <property type="entry name" value="FRB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057564">
        <property type="entry name" value="HEAT_ATR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024585">
        <property type="entry name" value="mTOR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026683">
        <property type="entry name" value="TOR_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF126">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08771">
        <property type="entry name" value="FRB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23593">
        <property type="entry name" value="HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11865">
        <property type="entry name" value="mTOR_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01346">
        <property type="entry name" value="DUF3385"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01345">
        <property type="entry name" value="Rapamycin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47212">
        <property type="entry name" value="FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="12">
        <location>
            <begin position="1347"/>
            <end position="1861"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="11">
        <location>
            <begin position="2036"/>
            <end position="2353"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="13">
        <location>
            <begin position="2406"/>
            <end position="2438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1375"/>
            <end position="1394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1375"/>
            <end position="1387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG5468080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="2438" mass="274352" checksum="F121DBAF8A4E87D3" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KF97</accession>
    <name>A0A836KF97_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Squalene synthase</fullName>
            <shortName evidence="11">SQS</shortName>
            <shortName evidence="11">SS</shortName>
            <ecNumber evidence="4 11">2.5.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_03404</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">LSCM4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2 (2E,6E)-farnesyl diphosphate + NADH + H(+) = squalene + 2 diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:32299"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2 (2E,6E)-farnesyl diphosphate + NADPH + H(+) = squalene + 2 diphosphate + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:32295"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the phytoene/squalene synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.21" evidence="4 11"/>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060963.1">
        <property type="nucleotide sequence ID" value="XM_067205411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KF97"/>
    <dbReference type="SMR" id="A0A836KF97"/>
    <dbReference type="GeneID" id="92359345"/>
    <dbReference type="KEGG" id="loi:92359345"/>
    <dbReference type="UniPathway" id="UPA00767">
        <property type="reaction ID" value="UER00751"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055056">
        <property type="term" value="F:D-glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051996">
        <property type="term" value="F:squalene synthase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045338">
        <property type="term" value="P:farnesyl diphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00683">
        <property type="entry name" value="Trans_IPPS_HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000003">
        <property type="entry name" value="Farnesyl-diphosphate farnesyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006449">
        <property type="entry name" value="Squal_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019845">
        <property type="entry name" value="Squalene/phytoene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044844">
        <property type="entry name" value="Trans_IPPS_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033904">
        <property type="entry name" value="Trans_IPPS_HH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01559">
        <property type="entry name" value="squal_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11626">
        <property type="entry name" value="FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11626:SF2">
        <property type="entry name" value="SQUALENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01018">
        <property type="entry name" value="Squalene/Phytoene_Synthase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01044">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01045">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5471846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="414" mass="46971" checksum="8269CF33C3E6287F" modified="2021-09-29" version="1">MGLLSDSLVMMRVKWRLRSVKLDVPPGETDLRFCYEVMDSVSRSFAVVVAQLADQQLRDAVCIFYLVLRALDTVEDDMSVPVEVKLKELPAFHTHTNDMSWCMSGVGEGRERELLEKYQCVSRAFKKLKKDYQDVIVNICERMANGMCDFLKRPVLTKDDYNLYCHYVAGLVGHGLTHLFARCGFEDPHLDNDLTSANHMGLFLQKTNIIRDYYEDIREEPPRMFWPKEIWGVYATELSELKKESNKMAAVQCLNAMVADALVHIPHVVDYLSALRDPSVFRFCAIPQLMAIATLKEVYNNPDTFQVKVKVSRPESCRITLKATTLYSALNMLRDYCVELQEKLDMEDASSTSIANSLAAAMERIDVQLKKCVDVSYTRSLLARYPGLGGQFVLTVIDTVSGFFGGRKEMAGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KGR4</accession>
    <name>A0A836KGR4_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_04086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062012.1">
        <property type="nucleotide sequence ID" value="XM_067206075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KGR4"/>
    <dbReference type="SMR" id="A0A836KGR4"/>
    <dbReference type="GeneID" id="92360009"/>
    <dbReference type="KEGG" id="loi:92360009"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5475504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="85" mass="9219" checksum="C562F5EE8954BE90" modified="2021-09-29" version="1">MLRLTTARYYQSVAASIGKGCVVPMKFDSLKPAYVPKSFTTQFFVLGTWSISNMITNFVIGFLIIAAANGGLSGAWPPDPHTLHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KJY8</accession>
    <name>A0A836KJY8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">S-adenosyl-methyltransferase mraW-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_04767</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. RsmH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000023">
        <property type="protein sequence ID" value="KAG5478534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063195.1">
        <property type="nucleotide sequence ID" value="XM_067206748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KJY8"/>
    <dbReference type="SMR" id="A0A836KJY8"/>
    <dbReference type="GeneID" id="92360682"/>
    <dbReference type="KEGG" id="loi:92360682"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071424">
        <property type="term" value="F:rRNA (cytosine-N4-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.170">
        <property type="entry name" value="Putative methyltransferase TM0872, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002903">
        <property type="entry name" value="RsmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023397">
        <property type="entry name" value="SAM-dep_MeTrfase_MraW_recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11265:SF0">
        <property type="entry name" value="12S RRNA N4-METHYLCYTIDINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11265">
        <property type="entry name" value="S-ADENOSYL-METHYLTRANSFERASE MRAW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01795">
        <property type="entry name" value="Methyltransf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81799">
        <property type="entry name" value="Putative methyltransferase TM0872, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="60"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5478534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="491" mass="54814" checksum="E0702F981D0AFBD3" modified="2021-09-29" version="1">MKRIVAPKRWSARNRVEDPPLMPKQLLQGVCGGLRWLECKNLAEFLAKRAIEDGFPCTKGQQRALNAQPPSSSRPAPRKSRLRKRGLGRPSVGAGGWTAGILEAPRTTGASDAVVSSDAALALNTTSALDALVPLEKQKRLVSYDVLDCTFGSGFHTGVVLENGWPYTRVVAMDCDLGAMVSAREIANEFGANRFRFYARPMSEAKAMFGERSFDAVMIDPGPSFTQLENPERGFLLDEDSDHALDMRYGPTYGVGALEYLNTVPQHALSGALASYELLTPQQSMKLARAIRQRRPFDGAQRVLEVVEEAGNELPEEGWMTQSSRRKVSMSWNFMTSLRCIVNHERHELSEALQNALLLLRTDGRLVVFSRLQWEEKLISATISQHPHALLSYSEAIPIDDVQEHGHSRHTKMWIATRTQSSSYVLKNSQTLTEEAVLESSMRWMGGLFAGQTFGFPANNFTFENKDRKEWAAVRRNKDPPPFDSDDDPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KK80</accession>
    <name>A0A836KK80_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">40S ribosomal protein S19 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_03730</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061663.1">
        <property type="nucleotide sequence ID" value="XM_067205726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KK80"/>
    <dbReference type="SMR" id="A0A836KK80"/>
    <dbReference type="GeneID" id="92359660"/>
    <dbReference type="KEGG" id="loi:92359660"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000593">
        <property type="entry name" value="40S ribosomal protein S19 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001266">
        <property type="entry name" value="Ribosomal_eS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01090">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01413">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5473660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="161" mass="18008" checksum="760FEE13BBFA387E" modified="2021-09-29" version="1">MTASSNKIRRVGKRKGATLKDVSAWRWIKTAARRFKQEGKLFVPNCTEIMKSSHGRERAPQNSDWYYIRCAAVLRAIYLRSGVGYGGLSKRFGNKKNYGSRPEHTVSSSTGPLHWACKSLTKLGLVEPGAQSGQRLTRKGHKFADALAFQVHIRKFGQAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KMJ5</accession>
    <name>A0A836KMJ5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protoheme IX farnesyltransferase, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Heme O synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_04815</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000023">
        <property type="protein sequence ID" value="KAG5478582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063243.1">
        <property type="nucleotide sequence ID" value="XM_067206796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KMJ5"/>
    <dbReference type="SMR" id="A0A836KMJ5"/>
    <dbReference type="GeneID" id="92360730"/>
    <dbReference type="KEGG" id="loi:92360730"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008495">
        <property type="term" value="F:protoheme IX farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13957">
        <property type="entry name" value="PT_UbiA_Cox10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000006">
        <property type="entry name" value="Protoheme IX farnesyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006369">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01473">
        <property type="entry name" value="cyoE_ctaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448:SF2">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5478582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="386" mass="41644" checksum="A1F03E6475BFB239" modified="2021-09-29" version="1">MMLRITAARHAQLFRLTQRRLLLGTFTACPYHRAKEGSATAMAQGAMEHCPVVGAAPRTSCPIEVDLCDRRAPTMSAMVSQMGKVQLSAYVAATALAGYVIAGGTSTLIAAAVTAGTMLQSCSANTANQIIEAPYDRLMKRTCRRPLPMKFISPQAAAAISGMELALGTGLLYCASPPAAALGVFNWFLYVCAYTPLKRISALNTWFGSIVGGVPPLMGGVAVAGSITPPVWLLATFLFVWQIPHFNGLAFHCRRDYEAAGYKMLAFYNPWRASFYAVALSVIMAFLTLVCPTLAGVEVEGVWYYSVTAAANALMIYKSILFHNEPVRHCRGCFVFSYVYLSVVLAAMMLNHIQPMHLAQRSIDYITAETTEASAASSAMLSTVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KML6</accession>
    <name>A0A836KML6_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062368.1">
        <property type="nucleotide sequence ID" value="XM_067207065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KML6"/>
    <dbReference type="SMR" id="A0A836KML6"/>
    <dbReference type="GeneID" id="92360999"/>
    <dbReference type="KEGG" id="loi:92360999"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5476135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="126" mass="14688" checksum="FC9B47EDB4742EAA" modified="2021-09-29" version="1">MLRRTHTSLFRRTPVRLSGGELYHPPKLEDIPPSSATKGFFGAYNGSLTVLRFIDIKWMMNRAVELGREYYISAPTLYLFLWMFCWKGFVIMRYGDGKPPRQVDWNTEETGYLPQGFEQTKVTKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KMZ3</accession>
    <name>A0A836KMZ3_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_07095</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000018">
        <property type="protein sequence ID" value="KAG5481384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064063.1">
        <property type="nucleotide sequence ID" value="XM_067209000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KMZ3"/>
    <dbReference type="SMR" id="A0A836KMZ3"/>
    <dbReference type="GeneID" id="92362934"/>
    <dbReference type="KEGG" id="loi:92362934"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="257"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="766"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="859"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="660"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="278"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="308"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="399"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="430"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="464"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="766"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5481384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="913" mass="97319" checksum="E441F2EF33B8FA4F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KND2</accession>
    <name>A0A836KND2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cilia- and flagella-associated protein 206</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_06864</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CFAP206 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000017">
        <property type="protein sequence ID" value="KAG5481789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064149.1">
        <property type="nucleotide sequence ID" value="XM_067208775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KND2"/>
    <dbReference type="GeneID" id="92362709"/>
    <dbReference type="KEGG" id="loi:92362709"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030030">
        <property type="term" value="P:cell projection organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003356">
        <property type="term" value="P:regulation of cilium beat frequency"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021897">
        <property type="entry name" value="FAP206"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21442">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21442:SF0">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5481789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="708" mass="77148" checksum="11B8B7CBE3E2EDEA" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KNL1</accession>
    <name>A0A836KNL1_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_04357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062551.1">
        <property type="nucleotide sequence ID" value="XM_067206342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KNL1"/>
    <dbReference type="SMR" id="A0A836KNL1"/>
    <dbReference type="GeneID" id="92360276"/>
    <dbReference type="KEGG" id="loi:92360276"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5477140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="215" mass="23264" checksum="0B162BEE204ED526" modified="2021-09-29" version="1">MAEAADALLLSLEVEAAAARNAELSQTIDALQDEVRRLRRANASPFAGDVRQPPRVSPPSAEELSATVQVHCEGSPAAADAKEVFLILDKLLFELADIRSRVSPDEYVDLSRRAFSAATTVRAHATRCLEEARKLKVALVVKQQSTAAQVSELRRALGEQVEATEKQSAAVPVQSTLRERACAELQRSHEETVSSRGACALDRVIQATVQRSPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KNZ0</accession>
    <name>A0A836KNZ0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_05599</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000016">
        <property type="protein sequence ID" value="KAG5482344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064350.1">
        <property type="nucleotide sequence ID" value="XM_067207536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KNZ0"/>
    <dbReference type="SMR" id="A0A836KNZ0"/>
    <dbReference type="GeneID" id="92361470"/>
    <dbReference type="KEGG" id="loi:92361470"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051031">
        <property type="entry name" value="RING-box_E3_Ubiquitin_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024766">
        <property type="entry name" value="Znf_RING_H2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11210">
        <property type="entry name" value="RING BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12678">
        <property type="entry name" value="zf-rbx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="55"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5482344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="105" mass="11684" checksum="F022592A10DCB6A9" modified="2021-09-29" version="1">MASPSTASSPSAAEHDFIIPIETRYMYVTARSVPRETLLMTGDCPICKSALGQPCVKCTPSMDECSVVVGVCSHIFHLHCLEQWLQGTCPLCRNQWQQERIIQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KQF6</accession>
    <name>A0A836KQF6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">p-glycoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_07249</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000015">
        <property type="protein sequence ID" value="KAG5483036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064532.1">
        <property type="nucleotide sequence ID" value="XM_067209149.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836KQF6"/>
    <dbReference type="GeneID" id="92363083"/>
    <dbReference type="KEGG" id="loi:92363083"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000836">
        <property type="entry name" value="ABC transporter B family member 25"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </location>
    </feature>
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        <source>
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        <source>
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        </source>
    </evidence>
    <sequence length="663" mass="74907" checksum="BB6E0FD13970158F" modified="2021-09-29" version="1"> </sequence>
</entry>
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                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1">LSCM4</strain>
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    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="IRON-SULFUR CLUSTER CO-CHAPERONE PROTEIN HSCB"/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="32221" checksum="6850F65348EDEACA" modified="2021-09-29" version="1">MPAQCALLAQRRLLKGLIVRAQAPAACWTVPLLWMAPQRWCSSSSASTETPAHSSVARKGNYFNFFQIARHPEVDVAALQKKYHRLQRLVHPDQQQVQARERLLLQKQAEAVIAPPATSASPRSFPRIPDELESDVDISTYANTAYETLRTPYSRCRYLSRLVKAEEVKGSPLTAAEEEELLVEDDRRTMKVREVRPDTPMSDDFLTEMLSVNELIFGGDSSDEGVRRQWSVLRFDLEDREVGCFKDAVKSWNEGDMGAFHHIVQEWTYVAAALDNLKERMLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KUA1</accession>
    <name>A0A836KUA1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">5'-3' exoribonuclease 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">LSCM4_07724</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000006">
        <property type="protein sequence ID" value="KAG5487236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065733.1">
        <property type="nucleotide sequence ID" value="XM_067209603.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836KUA1"/>
    <dbReference type="GeneID" id="92363537"/>
    <dbReference type="KEGG" id="loi:92363537"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18673">
        <property type="entry name" value="PIN_XRN1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1050:FF:000004">
        <property type="entry name" value="5'-3' exonuclease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000005">
        <property type="entry name" value="5'-3' exoribonuclease 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041385">
        <property type="entry name" value="SH3_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040992">
        <property type="entry name" value="XRN1_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047007">
        <property type="entry name" value="XRN1_D1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041106">
        <property type="entry name" value="XRN1_D2_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041412">
        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Xrn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047008">
        <property type="entry name" value="XRN1_SH3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF75">
        <property type="entry name" value="EXONUCLEASE XRNA, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18129">
        <property type="entry name" value="SH3_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18332">
        <property type="entry name" value="XRN1_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18334">
        <property type="entry name" value="XRN1_D2_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17846">
        <property type="entry name" value="XRN_M"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="Xrn1 N-terminal" evidence="13">
        <location>
            <begin position="1"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Xrn1 helical" evidence="14">
        <location>
            <begin position="291"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Xrn1 helical" evidence="14">
        <location>
            <begin position="406"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exoribonuclease 1 D1" evidence="16">
        <location>
            <begin position="620"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease Xrn1 D2/D3" evidence="17">
        <location>
            <begin position="991"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exoribonuclease 1 SH3-like" evidence="15">
        <location>
            <begin position="1128"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1243"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1364"/>
            <end position="1451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1260"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1313"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1372"/>
            <end position="1431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF18332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF18334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG5487236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1504" mass="167338" checksum="4C76940BBC85C32B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KV04</accession>
    <name>A0A836KV04_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_08141</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000002">
        <property type="protein sequence ID" value="KAG5488164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066212.1">
        <property type="nucleotide sequence ID" value="XM_067210014.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92363948"/>
    <dbReference type="KEGG" id="loi:92363948"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033370">
        <property type="entry name" value="COG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31658">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31658:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="116"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1867"/>
            <end position="1890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1876"/>
            <end position="1886"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5488164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1976" mass="205082" checksum="D07F229FE6D84AC9" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KV38</accession>
    <name>A0A836KV38_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_08331</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000001">
        <property type="protein sequence ID" value="KAG5488254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066301.1">
        <property type="nucleotide sequence ID" value="XM_067210200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KV38"/>
    <dbReference type="GeneID" id="92364134"/>
    <dbReference type="KEGG" id="loi:92364134"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5488254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="210" mass="23555" checksum="25A1FF863AE648FA" modified="2021-09-29" version="1">MPTTQYRFGYELKSKQVRVYQPHDLGSVQRAITANLQEYLVYEGVQEEDPTSLKKLLVKVLTLGVAAEVYALSKLQASGLPLACSFLFFGVLVAFQVACSVLQCNGNVIFVGTGRPIEDQSRSQKPCFRKLKNKRLCFRLTQESMSCPVVTLEVQLIGPSRLFSPPTVYSRVQKKVQYGQFFGSTGFFFPPPLLKLIDEMLDAVVSKKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KWG0</accession>
    <name>A0A836KWG0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_08349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000001">
        <property type="protein sequence ID" value="KAG5488272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066319.1">
        <property type="nucleotide sequence ID" value="XM_067210218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KWG0"/>
    <dbReference type="SMR" id="A0A836KWG0"/>
    <dbReference type="GeneID" id="92364152"/>
    <dbReference type="KEGG" id="loi:92364152"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17639">
        <property type="entry name" value="LC_FACS_euk1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF105">
        <property type="entry name" value="ACYL COA SYNTHETASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="127"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5488272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="714" mass="77607" checksum="1BC5A472AB024112" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KY76</accession>
    <name>A0A836KY76_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">2,4-dienoyl-coa reductase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_07800</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000006">
        <property type="protein sequence ID" value="KAG5487310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065807.1">
        <property type="nucleotide sequence ID" value="XM_067209677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KY76"/>
    <dbReference type="SMR" id="A0A836KY76"/>
    <dbReference type="GeneID" id="92363611"/>
    <dbReference type="KEGG" id="loi:92363611"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051793">
        <property type="entry name" value="NADH:flavin_oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42917">
        <property type="entry name" value="2,4-DIENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42917:SF2">
        <property type="entry name" value="2,4-DIENOYL-COA REDUCTASE [(2E)-ENOYL-COA-PRODUCING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0288">FMN</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="10">
        <location>
            <begin position="16"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="11">
        <location>
            <begin position="404"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5487310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="725" mass="80526" checksum="FC7680B2F7140F97" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KZL8</accession>
    <name>A0A836KZL8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline transporter-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_04865</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Choline transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000014">
        <property type="protein sequence ID" value="KAG5483713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064652.1">
        <property type="nucleotide sequence ID" value="XM_067206843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KZL8"/>
    <dbReference type="GeneID" id="92360777"/>
    <dbReference type="KEGG" id="loi:92360777"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF4">
        <property type="entry name" value="PROTEIN PNS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="505"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="532"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="50"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5483713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="604" mass="64798" checksum="18825B72A8503B3E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836L435</accession>
    <name>A0A836L435_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S ribosomal protein L10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_07533</name>
        <name evidence="5" type="ORF">LSCM4_07554</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">LSCM4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000004">
        <property type="protein sequence ID" value="KAG5487853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFHLR010000004">
        <property type="protein sequence ID" value="KAG5487873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066050.1">
        <property type="nucleotide sequence ID" value="XM_067209418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836L435"/>
    <dbReference type="SMR" id="A0A836L435"/>
    <dbReference type="GeneID" id="92363352"/>
    <dbReference type="KEGG" id="loi:92363352"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="entry name" value="Ribosomal protein L10e/L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047873">
        <property type="entry name" value="Ribosomal_uL16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018255">
        <property type="entry name" value="Ribosomal_uL16_CS_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_uL16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001197">
        <property type="entry name" value="Ribosomal_uL16_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_uL16_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003239">
        <property type="entry name" value="PRK04199.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00279">
        <property type="entry name" value="uL16_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11726">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005590">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="Ribosomal protein L16p/L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01257">
        <property type="entry name" value="RIBOSOMAL_L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5487853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5487873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="24555" checksum="22EB4E22E2E02B60" modified="2021-09-29" version="1">MARRPSRCYRFCKNKPYPKSRFCRGVPDPKIRNFDIGRRRATVDEFPVCIHVVSRELEQIASEALEAARIQANKYMVKRANKDVFHMRTRAHPFHVLRINKMLSCAGADRLQTGMRGAFGKPNGVCARVRIGQILLSMRTKEAYVPQAYEALRRAKMKFPGRQIIVTSKYWGFTNILRTEYEALRDAGKLEQRGIHCKLIAPKGKITMRNVMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FLT0</accession>
    <name>A0A836FLT0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase M3A/M3B catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_00479</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase M3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058658.1">
        <property type="nucleotide sequence ID" value="XM_067202557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836FLT0"/>
    <dbReference type="SMR" id="A0A836FLT0"/>
    <dbReference type="GeneID" id="92356491"/>
    <dbReference type="KEGG" id="loi:92356491"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000060">
        <property type="entry name" value="Mitochondrial intermediate peptidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
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<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5468961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059938.1">
        <property type="nucleotide sequence ID" value="XM_067204386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G6H0"/>
    <dbReference type="SMR" id="A0A836G6H0"/>
    <dbReference type="GeneID" id="92358320"/>
    <dbReference type="KEGG" id="loi:92358320"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5468961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="295" mass="32620" checksum="601202BE14223F63" modified="2021-09-29" version="1">MALVSYRCSRVATSAKKTAFSGAFCNERRCMSGGGRGDLFKRHASAFRPPTSGVLRGLTHSSQTTQPQSGQLQARKRIEHALYDRASSGSGHHRAAVATWSYLLPSLRGNVERAVPLTLYEKLRTDTEPLTSAESQRLADAQRLLRFELQQRVALLEDSLADAELVHLLQWPALFQRVWLRLPMDQSRALATEVRRDALVPAPPSSVHVPAVLPIAVWAPANFRASPSICASEPMKRGALASRLAQLTGHVVNCVEEDLRRLEHDCAPRSRRQAALEATWRAQWAASLNWHAGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G6U4</accession>
    <name>A0A836G6U4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Roadblock/LAMTOR2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GAMAD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059399.1">
        <property type="nucleotide sequence ID" value="XM_067203708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G6U4"/>
    <dbReference type="SMR" id="A0A836G6U4"/>
    <dbReference type="GeneID" id="92357642"/>
    <dbReference type="KEGG" id="loi:92357642"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032008">
        <property type="term" value="P:positive regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.30:FF:000004">
        <property type="entry name" value="ragulator complex protein LAMTOR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037587">
        <property type="entry name" value="LAMTOR2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13323">
        <property type="entry name" value="LATE ENDOSOMAL/LYSOSOMAL MP1 INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103196">
        <property type="entry name" value="Roadblock/LC7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5466509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="138" mass="14542" checksum="836ED42363B0FD64" modified="2021-09-29" version="1">MLCASDLNAVVSSAVGDDVLMALLLDASGNAIATAFAGSAAQRDILHAPLVAATANMWRAYAHSDLATNKLNLELESESLEQIIVSFPDKKICAMSVADTAVVSLVSVNESVTEGFLKLKTAALQRKLDRLLRPVMVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GBA8</accession>
    <name>A0A836GBA8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_02332</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5468939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059916.1">
        <property type="nucleotide sequence ID" value="XM_067204364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GBA8"/>
    <dbReference type="GeneID" id="92358298"/>
    <dbReference type="KEGG" id="loi:92358298"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF147">
        <property type="entry name" value="PALMITOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="270"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="9">
        <location>
            <begin position="218"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="518"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5468939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="570" mass="63603" checksum="1E93BF37AE5376A6" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GDQ5</accession>
    <name>A0A836GDQ5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosomal RNA methyltransferase FtsJ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_03148</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060716.1">
        <property type="nucleotide sequence ID" value="XM_067205164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GDQ5"/>
    <dbReference type="SMR" id="A0A836GDQ5"/>
    <dbReference type="GeneID" id="92359098"/>
    <dbReference type="KEGG" id="loi:92359098"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008650">
        <property type="term" value="F:rRNA (uridine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF19">
        <property type="entry name" value="METHYLTRANSFERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="5">
        <location>
            <begin position="2"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="260"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5471599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="335" mass="36551" checksum="45F283CF96886C48" modified="2021-09-29" version="1">MYRCQSAMKLIELNGRYQLFHRFRPSTVVDLAAAPGGFAQAALELMHPPESAPPSTLPPMVIAVDQRPIDPLPGLVAVRGNILQHHRILQTVQCALSHAGAPHTSPPRLSSSAYAAPLERSVDMVLHDGVSVVKGQRAFSVTYAQNQMALSSLLLASKLFQRFGPTPHVPTNAEQHPSSETGGRIHRNAAAANSLSSVLSVCFVSKVLECRHFAQVFAATRALFRHVSAFKPLTSRSESLERYVVASHFQLAAWQRLTTPHAPALQSNPRPRRDHRRSTASASLFSMPPAPDDCGDVRHIIWNCLGCGRTCMGCHPCGHCGPYRSVDGERGRKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GED0</accession>
    <name>A0A836GED0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CHORD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_06214</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000020">
        <property type="protein sequence ID" value="KAG5480447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063778.1">
        <property type="nucleotide sequence ID" value="XM_067208138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GED0"/>
    <dbReference type="SMR" id="A0A836GED0"/>
    <dbReference type="GeneID" id="92362072"/>
    <dbReference type="KEGG" id="loi:92362072"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1130.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007051">
        <property type="entry name" value="CHORD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12621">
        <property type="entry name" value="CYSTEINE AND HISTIDINE-RICH DOMAIN CHORD -CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12621:SF7">
        <property type="entry name" value="CYSTEINE AND HISTIDINE-RICH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04968">
        <property type="entry name" value="CHORD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51401">
        <property type="entry name" value="CHORD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CHORD" evidence="4">
        <location>
            <begin position="108"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="CHORD" evidence="4">
        <location>
            <begin position="234"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5480447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="296" mass="33680" checksum="25BB6F8E480658CC" modified="2021-09-29" version="1">MRVYCIYDGKNVKGDLVNNVAEPFKLKIDIPASWQQGPCERLLSFFLKTLRTKRDIDVAAEDVIMMCSGVDLKLQDSLANCISNYNDIYVLHKAAGKVEETHEGELRCTNFGCNQHYREEENTDTSCHHHSKGPVFHDLEKYWGCCEDRKAFDWESFEQIPRCCVGRHSTANKPFVFPKEEVHNIPLTASQAAYASASPSAMYDGKRVTGPREFEGAAVVQTEPQRIVDGKARCRNYGCAKEFVVAENTNSSCRYHRDGPVFWDTYKYWKCCPGKKCLEFDDFVKVPGCCEGAHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GIM5</accession>
    <name>A0A836GIM5_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_01252</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059000.1">
        <property type="nucleotide sequence ID" value="XM_067203309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GIM5"/>
    <dbReference type="SMR" id="A0A836GIM5"/>
    <dbReference type="GeneID" id="92357243"/>
    <dbReference type="KEGG" id="loi:92357243"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="440"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="594"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="646"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="510"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="140"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="168"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="457"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="612"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="697"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5466110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="834" mass="89070" checksum="E39B0BD7C6D9EA8C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GJ17</accession>
    <name>A0A836GJ17_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ER lumen protein-retaining receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_03802</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ERD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061735.1">
        <property type="nucleotide sequence ID" value="XM_067205798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GJ17"/>
    <dbReference type="SMR" id="A0A836GJ17"/>
    <dbReference type="GeneID" id="92359732"/>
    <dbReference type="KEGG" id="loi:92359732"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046923">
        <property type="term" value="F:ER retention sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000133">
        <property type="entry name" value="ER_ret_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10585">
        <property type="entry name" value="ER LUMEN PROTEIN RETAINING RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00810">
        <property type="entry name" value="ER_lumen_recept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00660">
        <property type="entry name" value="ERLUMENR"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00952">
        <property type="entry name" value="ER_LUMEN_RECEPTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
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                <person name="Al-Salem W.S."/>
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                <person name="Bates M.D."/>
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</entry>
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            </authorList>
            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
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                <person name="Gatherer D."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="578"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="612"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="680"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1151"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1235"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1272"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="688"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1165"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1237"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1283"/>
            <end position="1292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5479236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1396" mass="143059" checksum="B48904FA5F531617" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GQW4</accession>
    <name>A0A836GQW4_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_04452</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062645.1">
        <property type="nucleotide sequence ID" value="XM_067206436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GQW4"/>
    <dbReference type="GeneID" id="92360370"/>
    <dbReference type="KEGG" id="loi:92360370"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5477234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="103" mass="10955" checksum="BB6280AA94AE1D80" modified="2021-09-29" version="1">MYSPELEWLLGGATAVQQRTVLKASARSGCSVPASDALPRASAPESMAVDCHTMLPSPPGVRTTERSRCNPGLYSDVQVIGGLPPRGPREPADTFSPMPCRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GR34</accession>
    <name>A0A836GR34_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial</fullName>
            <ecNumber evidence="6">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Succinyl-CoA synthetase subunit alpha</fullName>
            <shortName evidence="6">SCS-alpha</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_04573</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">LSCM4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>succinate + ATP + CoA = succinyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with the ATP-specific beta subunit SUCLA2, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with the GTP-specific beta subunit SUCLG2 forms a GDP-forming succinyl-CoA synthetase (G-SCS).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 8">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="6"/>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062765.1">
        <property type="nucleotide sequence ID" value="XM_067206556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GR34"/>
    <dbReference type="SMR" id="A0A836GR34"/>
    <dbReference type="GeneID" id="92360490"/>
    <dbReference type="KEGG" id="loi:92360490"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009361">
        <property type="term" value="C:succinate-CoA ligase complex (ADP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004776">
        <property type="term" value="F:succinate-CoA ligase (GDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000002">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000005">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01988">
        <property type="entry name" value="Succ_CoA_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005810">
        <property type="entry name" value="CoA_lig_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004230">
        <property type="entry name" value="PRK05678.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01019">
        <property type="entry name" value="sucCoAalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117:SF2">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP_GDP-FORMING] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117">
        <property type="entry name" value="SUCCINYL-COA LIGASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001553">
        <property type="entry name" value="SucCS_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01798">
        <property type="entry name" value="SCOASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="CoA-binding" evidence="9">
        <location>
            <begin position="10"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="6 7">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="23"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="102"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit beta</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001553-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5477354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="299" mass="30733" checksum="5123A2749AC7E679" modified="2021-09-29" version="1">MFARSAIRRWINKDTKVIVQGMTGKAGTFHTKAAIAYGTKVVGGVSPKKAGTTALGVPVFATAAEAAKATGATASVLYVPAPACAASIEEALDAELPLVVVITEGIPQWDMLRVKSMLLSQNKTRLIGPNCPGIIKPAECKIGIMPGHIHQKGKIGIVSRSGTLTYEAVSQTTAVGLGQSLCVGIGGDPFNGTNMVDCLKLFLNDPETEGIILIGEIGGTAEEEAADFIKNSPIKKPIVSFIGGSTAPPGRRMGHAGAIVSGGMGTAKGKKEALRAAGVTISDSPADMGKHMAQLFAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GS48</accession>
    <name>A0A836GS48_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_05349</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-13 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5477954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062861.1">
        <property type="nucleotide sequence ID" value="XM_067207293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GS48"/>
    <dbReference type="GeneID" id="92361227"/>
    <dbReference type="KEGG" id="loi:92361227"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007019">
        <property type="term" value="P:microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01367">
        <property type="entry name" value="KISc_KIF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000012">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47971:SF4">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47971">
        <property type="entry name" value="KINESIN-RELATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4 6 7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="4"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="393"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="440"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="442"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="455"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="88"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5477954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="573" mass="62917" checksum="DAA351DC2366BC37" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GS72</accession>
    <name>A0A836GS72_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_06142</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">LSCM4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000020">
        <property type="protein sequence ID" value="KAG5480376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063707.1">
        <property type="nucleotide sequence ID" value="XM_067208067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GS72"/>
    <dbReference type="SMR" id="A0A836GS72"/>
    <dbReference type="GeneID" id="92362001"/>
    <dbReference type="KEGG" id="loi:92362001"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF75">
        <property type="entry name" value="CENTROMERE-ASSOCIATED PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="8">
        <location>
            <begin position="10"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="147"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="328"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="855"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="623"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="691"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="985"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="328"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="911"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="125"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5480376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1187" mass="127069" checksum="0E5FB5F30B41DEF3" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GT08</accession>
    <name>A0A836GT08_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cation/H+ exchanger transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LSCM4_04712</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000023">
        <property type="protein sequence ID" value="KAG5478479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063140.1">
        <property type="nucleotide sequence ID" value="XM_067206693.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836GT08"/>
    <dbReference type="GeneID" id="92360627"/>
    <dbReference type="KEGG" id="loi:92360627"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098719">
        <property type="term" value="P:sodium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF86">
        <property type="entry name" value="SODIUM_HYDROGEN EXCHANGER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="340"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="12">
        <location>
            <begin position="42"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="566"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1093"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="605"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1093"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1107"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1136"/>
            <end position="1156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG5478479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1498" mass="164597" checksum="E30167924157EB8F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GTL8</accession>
    <name>A0A836GTL8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SAM-dependent MTase RsmB/NOP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_00227</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058417.1">
        <property type="nucleotide sequence ID" value="XM_067202316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GTL8"/>
    <dbReference type="GeneID" id="92356250"/>
    <dbReference type="KEGG" id="loi:92356250"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808">
        <property type="entry name" value="NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808:SF1">
        <property type="entry name" value="RNA CYTOSINE-C(5)-METHYLTRANSFERASE NSUN2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="7">
        <location>
            <begin position="100"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="488"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="513"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="524"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="366"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5464786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="763" mass="83791" checksum="E1B07AA7AD8AD805" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GWC1</accession>
    <name>A0A836GWC1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Leucine-rich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_06105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000020">
        <property type="protein sequence ID" value="KAG5480339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063670.1">
        <property type="nucleotide sequence ID" value="XM_067208030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GWC1"/>
    <dbReference type="GeneID" id="92361964"/>
    <dbReference type="KEGG" id="loi:92361964"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058820">
        <property type="entry name" value="LRR_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26020">
        <property type="entry name" value="LRR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Leucine-rich" evidence="2">
        <location>
            <begin position="134"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5480339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="411" mass="45165" checksum="E4FCC27E8134A7E5" modified="2021-09-29" version="1">MGCRSSRLKSKKEGEDGKKGANVAGNGSRTGSGASTDTSTRSQSEETVEISAAVSYEGEQKHGAGEHLTDLAVKVERSANTNRYVTEGELNMTCPAELRTIMDNMSDLSTGSSSAPQLFHISPTERAEVEPGTWAWWREELRHERVTKDGYHRVLLQDVQTRLTIQHEDDPSTVELDLSNCYMEPTAPYVLGRLFASLQLKELRWITSLRLDGNYFTDAGFGTMLATMSAANEKQTILPVLRQLYLNNMNLDRHSVAGLFAYLFPVNRSATRSIPAKGALRIAGSRASRPSEDYITANKRGPTVPLFPSMSVLSLSDNPGVGTAGLILILRSFLAVHYEPHIFSVMDLSRCGIDRGASRYLREYFEQLSSAIDAGCCPVVPKRFVLMGNQHGIADSHDIYSPEGTGIQLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GWH8</accession>
    <name>A0A836GWH8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyruvate dehydrogenase E1 component subunit alpha</fullName>
            <ecNumber evidence="5">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_07136</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="5">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 5">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="5"/>
    <dbReference type="EMBL" id="JAFHLR010000018">
        <property type="protein sequence ID" value="KAG5481424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067209040.1"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
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        <source>
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    </evidence>
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            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5481424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="378" mass="42702" checksum="59189F3A12DB8763" modified="2021-09-29" version="1">MFKCATRCLLATKTVPLKPQRPFKLHTAGRTDMAPLPAETTYDAEQLKKSLALMFRIRRMESLCDQSYKLKKIRGFCHLYIGQEAIPAGMENVLTFEDPIVTGYRDHGWYISRGGTPEEVFAEMFGRQGGCSKGKGGSMHMYNVSNGFYGGNGIVGAQVSVGAGLAWRFAMENRDNPKHVAVTFYGDGAANQGQIYESMNIAALQRLPVIFAVENNHFGMGTSAARGSYQSEFYRRGDYIPGIKVDGMDVLAVQEGTRYARDHCTSGKGPIVMELDCYRYMGHSMSDPDNQYRTKSDIQHVKQERDCIRKMREFMAAEGIMTEEEMSKMEKDVKKEVDQDLQKAQKHPMTKLDELFTDIYVGEQYEHRTCQGTVYHKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GYD1</accession>
    <name>A0A836GYD1_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_01664</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067203712.1"/>
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    <dbReference type="GeneID" id="92357646"/>
    <dbReference type="KEGG" id="loi:92357646"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5466513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="287" mass="32819" checksum="646255D09DBE437C" modified="2021-09-29" version="1">MSRVTPKLPFKAWLKLHVKAICQALPLSLLIVVEARDLFYRATWAVTAVPPSKFEVGDVVAVCNRWYTLPTWSHIVYSLLSKVLLKSCWDDVGVISSVKNGKPHILYVDFRGVHEQPLDAFLEERCPRGAAVRKLHRDEGVPPLSPDVAGLFQQEAEKISAEPWFLFSASMRGGNEHKFYEFCVGMHEQRCKIRVMLQRRQSRQAIEAQQNSLKEMEVMRQHLAKFVEPVTHFHLYNGSLVASFFATYGLIDREMPSPSRYVPQDFAHTIPFCGATTLEEPIVFFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GZQ6</accession>
    <name>A0A836GZQ6_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_00804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067202877.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="92356811"/>
    <dbReference type="KEGG" id="loi:92356811"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="276"/>
        </location>
    </feature>
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            <end position="391"/>
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    </feature>
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        <location>
            <begin position="426"/>
            <end position="472"/>
        </location>
    </feature>
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        <location>
            <begin position="593"/>
            <end position="619"/>
        </location>
    </feature>
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        <location>
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            <end position="741"/>
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        <location>
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            <end position="856"/>
        </location>
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        <location>
            <begin position="941"/>
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            <end position="167"/>
        </location>
    </feature>
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            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
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        <location>
            <begin position="317"/>
            <end position="329"/>
        </location>
    </feature>
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        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
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    </feature>
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            <begin position="374"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
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        <location>
            <begin position="596"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="775"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="793"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="941"/>
            <end position="951"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5467725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="967" mass="101201" checksum="609703FA7D856A7D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H179</accession>
    <name>A0A836H179_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PI3K/PI4K catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_04294</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
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            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        </source>
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</entry>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG5477917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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        <location>
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            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="890"/>
        </location>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="859"/>
            <end position="889"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5485641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="912" mass="98615" checksum="F91C774C5C6B0B9F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H312</accession>
    <name>A0A836H312_9TRYP</name>
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            <fullName evidence="7">Leucine-rich repeat protein</fullName>
        </recommendedName>
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        <name evidence="5" type="ORF">LSCM4_04810</name>
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        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the ANP32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000023">
        <property type="protein sequence ID" value="KAG5478577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063238.1">
        <property type="nucleotide sequence ID" value="XM_067206791.1"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A836H312"/>
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    <dbReference type="KEGG" id="loi:92360725"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045081">
        <property type="entry name" value="AN32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11375">
        <property type="entry name" value="ACIDIC LEUCINE-RICH NUCLEAR PHOSPHOPROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11375:SF0">
        <property type="entry name" value="ACIDIC LEUCINE-RICH NUCLEAR PHOSPHOPROTEIN 32 FAMILY MEMBER A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="153"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="202"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5478577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="23276" checksum="22F89960D063A3C8" modified="2021-09-29" version="1">MEILKKTAALRVQKQTEGRPAEEVTQLSLSGVPVLPELWSPYTHLTHLLLICMKPKLVSLDMVGLHQLQALRLLDVSDNAVAVASAPPAVPSLARLLMPNNLVSSLEEVSRLAQSFPNLEVLDVADNDVDTPAHFASVFESFPKLVALNSRTRDGTEVVVEDSDESYSDEEYEESSDEEGQSASTGGSDSESGEESESDAELPAKRARTGDDRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H373</accession>
    <name>A0A836H373_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycerolphosphate mutase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_02536</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060115.1">
        <property type="nucleotide sequence ID" value="XM_067204563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H373"/>
    <dbReference type="GeneID" id="92358497"/>
    <dbReference type="KEGG" id="loi:92358497"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052765">
        <property type="entry name" value="PGM-Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46192">
        <property type="entry name" value="BROAD-RANGE ACID PHOSPHATASE DET1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="209"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="393"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="228"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="422"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="481"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="1">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5469138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="502" mass="56163" checksum="74DF7A210DEBB368" modified="2021-09-29" version="1">MWWTAARRRLYYPNQVFISRENRRIQHQWLPRRLLLVRHGESVANVNREVYSNTPDWKIPLTALGREQAYDCGKRLRNIIQDEKLYIYYSPYARTRQTLCEIRRSFDESQIQGEREDERLREQEMGNYQPLHEMDATWAARHAFGRLYYRFPFGESGADVGDRVSGFFDSLQRESIGLTVPNMNERLAHGAREELGCLGLGRWSTNDDDLPDAACDSPASPSKGATIASSTGNGSASLSSAPSSKHAAASCTGLRRTIRRSLRHHPVPLSDLGEAETRGVLPPNDHSASAGEEQNVLIVAHGLLIRLFIGRWFRVPMEVFETMCNPPNCAIVVLERDDRLGRLVMTDMSKNLFGSDPLLQMMRFDGREDTRWYRERFLGIVDPTKSVEEAVAEDDDENHYSMSHAHNSVVGPPTPPPRRRGPFTSTAECSSSSASTSVSDTDISSAEGVEALESGAGGAVETGERCAAQPVSPSPCMSRTSNRERVVHRRGVYDATKKGSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H3Z7</accession>
    <name>A0A836H3Z7_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_04397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062591.1">
        <property type="nucleotide sequence ID" value="XM_067206382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H3Z7"/>
    <dbReference type="GeneID" id="92360316"/>
    <dbReference type="KEGG" id="loi:92360316"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041090">
        <property type="entry name" value="DUF5578"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34258">
        <property type="entry name" value="ARMADILLO-LIKE HELICAL DOMAIN CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34258:SF1">
        <property type="entry name" value="ARMADILLO-LIKE HELICAL DOMAIN CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17741">
        <property type="entry name" value="DUF5578"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5477180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="676" mass="71250" checksum="6D802CEAB9127137" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H411</accession>
    <name>A0A836H411_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL4m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_06067</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000011">
        <property type="protein sequence ID" value="KAG5485429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065166.1">
        <property type="nucleotide sequence ID" value="XM_067207992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H411"/>
    <dbReference type="SMR" id="A0A836H411"/>
    <dbReference type="GeneID" id="92361926"/>
    <dbReference type="KEGG" id="loi:92361926"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746:SF6">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL4M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5485429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="458" mass="52541" checksum="BCA565ADC899A35A" modified="2021-09-29" version="1">MRRLACAAVSSSAALRFFVFRAMYDSWSSGVHDVAPRDEVDFLYEGPQQVLSGAHPLPLFHPENSVTRPPVSPYLPSPQRPHPYFTHELPELPHFSTTRPIVYTMGTIKQRIVAPVFDLANHVTHTRELDPFIFGMYPETEEMAKNLSYWLVRCQNFSSKWDYENREVWRKAKKNWPNTGMGMARVGDRKNHAHPWGAHSKPVKPWNLLMPTMDVKTWSKSNRMLVTLKMLQGKLQIVERLTLPEPTQEAYLRLCRTMGWDVRHKGGGALFMDGGSRITPSSEFDRAFFFGSFFNGRNKLVRPTLLCDEPYDYNRTSSKARTKGPKGQKNPIPINRFNAYDALTHDILVITEGALMQLEDEMFTHKLAMLPPHIRAQLPERGFLDSEVLGDALPALQTIQMEAAARTEEAEQAMYAPYYDNPYHLWKDEGEASYAVDAVEGTVQRYVKSRKTSWRMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H4D5</accession>
    <name>A0A836H4D5_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_06580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000010">
        <property type="protein sequence ID" value="KAG5485624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065208.1">
        <property type="nucleotide sequence ID" value="XM_067208497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H4D5"/>
    <dbReference type="GeneID" id="92362431"/>
    <dbReference type="KEGG" id="loi:92362431"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5485624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="452" mass="47300" checksum="AECDB5C9554E0FA9" modified="2021-09-29" version="1">MSVAIRVHPSVLLSIVDHVTRASLQQQQRQPRKQESAPDVAAASPLAPVFLSTVGLLMGTTKASGAADAKTRDHERGAGGIITTLSASFELPLRLRPDDGAPADVAPSGDSAFLRRVLSDETDWPAARKHREQLKAVMPEMEVVGCYVVCAGSRWTSTRQQKDGDGGDGSALSIGGAVKKAKREAMAKADGIVAIARCVQRLLRSSALLPSAATGFVLLAVYDKEVTGAVGETDSAVRDPQQSPAAARLPYECLYVAGATVSDTLPMAEATVCPADMEWIALANEAVTPAHHPSSTAAPSASVQPGILRRLCSAAYLASAAESSVTREPTGTQTAPMASSQNFRAAEELVGSLRLIMRLLVMMAASTTDTTVAAPDDVELLRAVATCLRNVPDSSSSKSQGEPTALCVPVTEEVLSVVLALEVQCALRMRSLSKAQQRPLSSGRSTTAALHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H6U4</accession>
    <name>A0A836H6U4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_05074</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062351.1">
        <property type="nucleotide sequence ID" value="XM_067207048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H6U4"/>
    <dbReference type="SMR" id="A0A836H6U4"/>
    <dbReference type="GeneID" id="92360982"/>
    <dbReference type="KEGG" id="loi:92360982"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5476118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="171" mass="19560" checksum="D58E2F945CC0BA95" modified="2021-09-29" version="1">MSPRGLRGADARFRPFLSSDLDAYLARYWAVVFTVGSRALETGYMRHYLSWYATRLKVVELDHHMHAISLRDQLITKAGTPALPILFVNQKLVGTIDDVRSYEERRLLKDIIQFGFQWKTGAALDGGPQQLNTLPSPYGDTELFRGRYRGAPVARPVVQLPQLHPHRRQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H8S3</accession>
    <name>A0A836H8S3_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000007">
        <property type="protein sequence ID" value="KAG5486909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065703.1">
        <property type="nucleotide sequence ID" value="XM_067208298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H8S3"/>
    <dbReference type="SMR" id="A0A836H8S3"/>
    <dbReference type="GeneID" id="92362232"/>
    <dbReference type="KEGG" id="loi:92362232"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="245"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5486909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="362" mass="40706" checksum="A4346C635F8397D4" modified="2021-09-29" version="1">MSLKQLAAFGTVAAFSVFGVVGGTRWRRIELRRAELNEEYTKLMTEMRTFNEERLTRDERLAAKEAEVKATAETVDILWNDRLERYAQVNKDLHAYLTALPEAIGALKGLSNHYRYMSEEMPKFMGFDIACSKMHNLALMLEHGKAVGIERVAATVREMFAAEPLVHTVCTSIIEAPAPPRPSSIAAASATFTFCMEEVDRAVGAVAMRYAAALEEPPAATPGILSDSVRKLVRMTRVDTLSRGQRQLAERRKDLERMLRRAQRQLHTEEDIRAALEYTKELNRHLAAVSPSRTGVSLSRSSSRNDFLSAVRSDSEVKKAVQQLDLWRDSATSFLVHRQAEDALRSYYLLLAETLTAVNELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HA16</accession>
    <name>A0A836HA16_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LSCM4_08044</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">LSCM4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000005">
        <property type="protein sequence ID" value="KAG5487599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065887.1">
        <property type="nucleotide sequence ID" value="XM_067209920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HA16"/>
    <dbReference type="SMR" id="A0A836HA16"/>
    <dbReference type="GeneID" id="92363854"/>
    <dbReference type="KEGG" id="loi:92363854"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03273">
        <property type="entry name" value="ABC_SMC2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1620:FF:000007">
        <property type="entry name" value="Structural maintenance of chromosomes protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001880">
        <property type="entry name" value="Structural maintenance of chromosomes protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027120">
        <property type="entry name" value="Smc2_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43977">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="14">
        <location>
            <begin position="518"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1185"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="463"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="701"/>
            <end position="944"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG5487599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1212" mass="136416" checksum="0F90854CD1F98A93" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HAG7</accession>
    <name>A0A836HAG7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">Adenylosuccinate lyase</fullName>
            <shortName evidence="9">ASL</shortName>
            <ecNumber evidence="4 9">4.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Adenylosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_07502</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate</text>
            <dbReference type="Rhea" id="RHEA:23920"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(6)-(1,2-dicarboxyethyl)-AMP = fumarate + AMP</text>
            <dbReference type="Rhea" id="RHEA:16853"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.2" evidence="4 9"/>
    <dbReference type="EMBL" id="JAFHLR010000004">
        <property type="protein sequence ID" value="KAG5487824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066021.1">
        <property type="nucleotide sequence ID" value="XM_067209389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HAG7"/>
    <dbReference type="SMR" id="A0A836HAG7"/>
    <dbReference type="GeneID" id="92363323"/>
    <dbReference type="KEGG" id="loi:92363323"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00132"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004018">
        <property type="term" value="F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01598">
        <property type="entry name" value="PurB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.10:FF:000010">
        <property type="entry name" value="Adenylosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000011">
        <property type="entry name" value="Adenylosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.200.10:FF:000004">
        <property type="entry name" value="Adenylosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004769">
        <property type="entry name" value="Pur_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047136">
        <property type="entry name" value="PurB_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013539">
        <property type="entry name" value="PurB_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006764">
        <property type="entry name" value="PRK09285.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00928">
        <property type="entry name" value="purB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43411">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43411:SF1">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08328">
        <property type="entry name" value="ASL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 9" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="10">
        <location>
            <begin position="39"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Adenylosuccinate lyase PurB C-terminal" evidence="11">
        <location>
            <begin position="357"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5487824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="479" mass="53786" checksum="D2D4C83A02D33323" modified="2021-09-29" version="1">MSVAEAREAAATAVSTTAHNTPAEILQDSPLYALSPLDGRYKRYTAPLRAFFSEYALFKYRVQVEVLYFQALCKEVPVITQLRGVTAAQLAQLRAATFENFTVDDAKKIKEMEAVTNHDIKAVEYYLKDKMSACGLEAEKEFIHFGLTSQDINNTSIPMLLRDALHHHYVPELDQLMALLKEKLPEWDVPMLARTHGQPASPTNLAKECMVWIERLEEQRAMLLSIPNTGKFGGATGNFNAHRCAYPGVDWREFGDLFLSKYLGLRRQRYTTQIEHYDNLAAICDACARLQTILMDLAKDMWQYISLGYFNQKVKVDEVGSSAMPHKVNPIDFENAEGNLGMSNAIFGFLSAKLPISRLQRDLTDSTVLRNLGVPLSHALIAFASLRRGVDKLLVNKAIIAADLESNWAVVAEGIQTVLRREGYPRPYEALKDLTRGNTHVTEATVRAFIQQLEGITEEVRQELLAITPFTYVGYTASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HB57</accession>
    <name>A0A836HB57_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SUMO-conjugating enzyme UBC9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin carrier protein 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LSCM4_08163</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000002">
        <property type="protein sequence ID" value="KAG5488184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066232.1">
        <property type="nucleotide sequence ID" value="XM_067210034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HB57"/>
    <dbReference type="SMR" id="A0A836HB57"/>
    <dbReference type="GeneID" id="92363968"/>
    <dbReference type="KEGG" id="loi:92363968"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019787">
        <property type="term" value="F:ubiquitin-like protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23798">
        <property type="entry name" value="UBCc_UBE2I"/>
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        <property type="entry name" value="UBQ-conjugating_AS"/>
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    </dbReference>
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            <end position="221"/>
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            <position position="157"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00039165"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00044296"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
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        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG5488184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="223" mass="24600" checksum="2EE738EE32EA2C13" modified="2021-09-29" version="1">MSGLSLAQSRLREERRAWRKDRPYGFWAKPLAITTGSERLSGVKHTREGAPSTLRAAAGTATGDATASSSSMAVLPSSAPSGADAAAARDFAAAAIPAGLDLLHWEAGIPGKPGTPWEGGEFRLRLNFTEDYPTKPPKCVFTPVLFHPNVYPSGTVCLSILNEEKDWRPNITIKQILLAIQELLDHPNVKDPAQEEPYKVYMRDIKEYEARVREEVQKHHWKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HBG9</accession>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
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        <name evidence="3" type="ORF">LSCM4_03814</name>
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        <name type="scientific">Leishmania orientalis</name>
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    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <location>
            <begin position="1"/>
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            <begin position="174"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5474641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="223" mass="23639" checksum="D7F95D5F95078224" modified="2021-09-29" version="1">MSRTSSMYVSPNLGPTAPWGQQTSTGVFRPPPAMSLSQSSASMPRYEGKLPPPCYSAGCGRSDATGEHGLAPGLVTAPTHPLGTSVVHDRHSEVGCPVAPSPPLRSASPPFYPQNQYSNVPSSFMLAGAHGVTGAANGDTSGSAATYPAGLIMKMISYAVHREEDAFLAKKESNRVLEKELLHEQELRRETQRQLEALDEMLQLLQGIHDAQSSLGASLGLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HDR8</accession>
    <name>A0A836HDR8_9TRYP</name>
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        <recommendedName>
            <fullName evidence="7">SPX domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="8" type="ORF">LSCM4_04062</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067206052.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="loi:92359986"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cit_transptr-like_dom"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="288"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="470"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
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        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="703"/>
            <end position="723"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5474883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="734" mass="81074" checksum="3B1E20048D96BFE8" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HE36</accession>
    <name>A0A836HE36_9TRYP</name>
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        <recommendedName>
            <fullName evidence="7">DAGKc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_05052</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062329.1">
        <property type="nucleotide sequence ID" value="XM_067207026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HE36"/>
    <dbReference type="GeneID" id="92360960"/>
    <dbReference type="KEGG" id="loi:92360960"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001727">
        <property type="term" value="F:lipid kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045540">
        <property type="entry name" value="YegS/DAGK_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF31">
        <property type="entry name" value="ACYLGLYCEROL KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19279">
        <property type="entry name" value="YegS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAGKc" evidence="7">
        <location>
            <begin position="338"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="781"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="611"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="797"/>
            <end position="807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5476096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="950" mass="102871" checksum="1457C9D60B32FF01" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HFB8</accession>
    <name>A0A836HFB8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FCP1 homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_07306</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000015">
        <property type="protein sequence ID" value="KAG5483090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064586.1">
        <property type="nucleotide sequence ID" value="XM_067209203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HFB8"/>
    <dbReference type="GeneID" id="92363137"/>
    <dbReference type="KEGG" id="loi:92363137"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5483090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="39379" checksum="8D7FBD3AC76CC83F" modified="2021-09-29" version="1">MRRPVAALPVHLLLDIDHTLVHPICHHVGGDSSVTTGCSGASLLSASAGARWPLNHVGGRTTRVQLRPHVVPFLSHVLLHNLLDTSEVQVHMSLYTRQSAAYCAFIARQVLLPALAQHSGRSLDMFLGREVFHGLYGGEHCVRGEFEAMQWVSPPPGFPAEGRLVDESQPLAAAESREWRKTIFVSPSPLTTLLIDDRCANFRATELCSGHGVLVPSYYTGAEKCAADDCFRVPPSSTLCGAIDPNDDGRCGDMSGARAMLGRVDVADVVVRLLDVVEAFVHCCHAHRRTIEEIRDGSAGISTAHERALSATLRATAMPRPPIDSALSNFNFFDRSPLYQQQWNAFHADSEHLLRSYFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HFC1</accession>
    <name>A0A836HFC1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA polymerase II-associated protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_04323</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the RPAP3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062246.1">
        <property type="nucleotide sequence ID" value="XM_067206309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HFC1"/>
    <dbReference type="SMR" id="A0A836HFC1"/>
    <dbReference type="GeneID" id="92360243"/>
    <dbReference type="KEGG" id="loi:92360243"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101031">
        <property type="term" value="C:protein folding chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051966">
        <property type="entry name" value="RPAP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025986">
        <property type="entry name" value="RPAP3-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46423">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46423:SF1">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13877">
        <property type="entry name" value="RPAP3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="RNA-polymerase II-associated protein 3-like C-terminal" evidence="7">
        <location>
            <begin position="373"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="284"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="6"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="325"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="363"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5475738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="489" mass="53618" checksum="A0DD6E7339A38FA6" modified="2021-09-29" version="1">MDRSVAEAIRQQSEDLRDELKELEQWEDAMQARETAMAQRKAPMLTSATTVEPPIRGTVPSLKVAVRQQQQQMRAAGAGGDAAAGAVTDPIQEAKEKGNALFQSGHLPEAVAAYTVGIDLDPASATTHVLYANRAMCYLKLGQWTAAEKDATTCVHMNTGYAKGYYRRAVARKQLGKLREARADLEAVLALAPRDISAQQEMESVTRALQAERAAASQTTTATATTKKRIVIEEVDSEGDEAATEAPAPSVSTLSVEEEELRNACIEEDMRRLAAARESREVQARQEAQREAAAQAKRQRRHERVEIVEEDEERGLNEKKETASSPATTVPAVARTAASSTSSPLASSSASPASVTTRARQRPSITKENLTTPKSFSEFERRFREVSQEPELRNYYVQQLNPATMAKLFGSNMTPEMLLGILQAVKTLNTTTALQYAKGLCEVSRVEDLTLFFNEEESAAVQDVLDLLRSAPGIPAKDIQRIERKLKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HGM4</accession>
    <name>A0A836HGM4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_04934</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
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    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <reaction evidence="9">
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    <comment type="catalytic activity">
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    <comment type="catalytic activity">
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            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
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            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
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            <dbReference type="Rhea" id="RHEA:69853"/>
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    <comment type="catalytic activity">
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            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
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            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
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    </comment>
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    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Dus family. Dus3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.89" evidence="3"/>
    <dbReference type="EMBL" id="JAFHLR010000017">
        <property type="protein sequence ID" value="KAG5481803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064163.1">
        <property type="nucleotide sequence ID" value="XM_067208789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HIA4"/>
    <dbReference type="GeneID" id="92362723"/>
    <dbReference type="KEGG" id="loi:92362723"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102265">
        <property type="term" value="F:tRNA-dihydrouridine47 synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45846">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45846:SF1">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="14">
        <location>
            <begin position="229"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="166"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="123"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="183"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG5481803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="586" mass="65086" checksum="81A7D5BF19EFE657" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HKS2</accession>
    <name>A0A836HKS2_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_04686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000023">
        <property type="protein sequence ID" value="KAG5478453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063114.1">
        <property type="nucleotide sequence ID" value="XM_067206667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HKS2"/>
    <dbReference type="GeneID" id="92360601"/>
    <dbReference type="KEGG" id="loi:92360601"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5478453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="54" mass="6325" checksum="735E5820076B1FE0" modified="2021-09-29" version="1">MRHRQEPRAGQDRKLRCASRPARLRPNSARRRSGLRSLPKSANLNEARPQYTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HMI2</accession>
    <name>A0A836HMI2_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_06305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000007">
        <property type="protein sequence ID" value="KAG5486840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065634.1">
        <property type="nucleotide sequence ID" value="XM_067208229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HMI2"/>
    <dbReference type="GeneID" id="92362163"/>
    <dbReference type="KEGG" id="loi:92362163"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5486840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="81" mass="9106" checksum="280A73ECCB043DB9" modified="2021-09-29" version="1">MSNSVAALLFLGLAFFVLYTLVIPKLFPAVVHRVGLIQLDKNTNTFFAFETTGVPIANNYNRSQVKANMRRRSHQYEAAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HMY2</accession>
    <name>A0A836HMY2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_07889</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">LSCM4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000013">
        <property type="protein sequence ID" value="KAG5484323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064816.1">
        <property type="nucleotide sequence ID" value="XM_067209766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HMY2"/>
    <dbReference type="SMR" id="A0A836HMY2"/>
    <dbReference type="GeneID" id="92363700"/>
    <dbReference type="KEGG" id="loi:92363700"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000033">
        <property type="entry name" value="40S ribosomal protein S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000530">
        <property type="entry name" value="Ribosomal_eS12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11843">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00972">
        <property type="entry name" value="RIBSOMALS12E"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032533938" description="40S ribosomal protein S12" evidence="5">
        <location>
            <begin position="25"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="6">
        <location>
            <begin position="183"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5484323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="295" mass="32336" checksum="A1383E99367FA83E" modified="2021-09-29" version="1">MLACGLRALSLSFRFASLLRLAFSLSFSLAGRGASLQAFRPTDANAGAQTCTAPPSSPLQPKLRVFRIRLCCSCHCCLAHLSATPLFCSLFLLLDGRLLSPHTHTHTHTLAQIRTPANTNTCPRNHAHVLTGADFVIRALTRSLFSFEKETITTMAEETARVEVPVVEENVVVDVAPESLEDAVRIVIQKALEANGLVRGLSEVARALDCKTAHMCILADDCEDEEYKKLVTALAKQGNIDLINVEEREKLAQWVGLVRRDVAGEVTKTLKCSSVAIRDFGERTKALDYLLSQLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HMZ2</accession>
    <name>A0A836HMZ2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_07904</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000013">
        <property type="protein sequence ID" value="KAG5484338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064831.1">
        <property type="nucleotide sequence ID" value="XM_067209781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HMZ2"/>
    <dbReference type="SMR" id="A0A836HMZ2"/>
    <dbReference type="GeneID" id="92363715"/>
    <dbReference type="KEGG" id="loi:92363715"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08250">
        <property type="entry name" value="Mgc45594_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000121">
        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051397">
        <property type="entry name" value="Zn-ADH-like_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677:SF3">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="20"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5484338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="346" mass="37394" checksum="E3ECB30F21DFBEE0" modified="2021-09-29" version="1">MQAMATAARTYRHIVAHQLSTNFRAATSIVEAPFPTELHPKAVLVKNRHLGINASDINFTAGVYQPDVRPPFVCGFEAVGEVVDVGSGVKDLKAGAAVLTQNYGAFAEYQVVARRHAKPIPRMAREYLPLGLSATTASIALEHVLKPQPGERAVVTAAAGGTGQFAVQLLKHVYGCPVVGTCSSPSKETFLTNTLKCDGVVNYMAEGDNTAAAFRRCYPRGITIAYESVGGDLLEAVIQSLTLRGRIVSVGCVSTYQSGSVEAVRPSRCKPLQLQLLAKSASLSTFFLPHFAKYEQQHFDRLCALHEQGVVQSCINPTTFKGLEGVYDAIDWMFEQKNCGKVMVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HWM3</accession>
    <name>A0A836HWM3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_06592</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000010">
        <property type="protein sequence ID" value="KAG5485636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065220.1">
        <property type="nucleotide sequence ID" value="XM_067208509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HWM3"/>
    <dbReference type="GeneID" id="92362443"/>
    <dbReference type="KEGG" id="loi:92362443"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="134"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5485636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="198" mass="21540" checksum="E61B14217508D286" modified="2021-09-29" version="1">MQRPREDNHDHHRRGHNTRHDEEERRKQTGSKSMGAAIALAFGAGALVFAGASALYSWCTRENTQRHQSYYCLPPRDGITGATAASTQLSPVTSAGADGKKRIEANEAISHSPVTVSDGCSAPLSAEAGGGHPCVCCLERQQSFMFVQCRHICLCEPCLIQLGRSYEDNTLRARFDGPVKLPCPVCRCVGYVVKTFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836I3A2</accession>
    <name>A0A836I3A2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ankyrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_08030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000005">
        <property type="protein sequence ID" value="KAG5487585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065873.1">
        <property type="nucleotide sequence ID" value="XM_067209906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836I3A2"/>
    <dbReference type="SMR" id="A0A836I3A2"/>
    <dbReference type="GeneID" id="92363840"/>
    <dbReference type="KEGG" id="loi:92363840"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="221"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="331"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="352"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5487585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="381" mass="42005" checksum="2CD4C1888D37806F" modified="2021-09-29" version="1">MNKHPRDICTAAFEGDTARVQQLVTAAGVYSERWHSPFVVDTSAAARDALVSWEVVENGEAGDNDGIEEDMEEVLGEEEMAKLTAHPALRGILKSYSLDAQADEGASDDEGAGAYGQDDDAMLFDEEAEEAAEEDRQAQQRDILIYKRLLAHQLHRDSIARHIQQHGLLHMSATPPVDMTLYGILFSCREVPAAATAGAAAVSESAVPLQVRWQPSKRSRYAGTPLHWAVLAREHDMVHFLVEHGADCTAGLKAVTYDGAAPDAQLAMYDQKVLATLTPARMAADNESHHTLEVLERAVAAQAATRADEEAFFILLEERLRRRKEAYLHRREEARTQRLHEAEEQARRAEAEEAEEATEGDMSGEDNDDGSDGEEDEEAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836I4F4</accession>
    <name>A0A836I4F4_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_08180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="protein sequence ID" value="KAG5488200.1"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5488200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="493" mass="52439" checksum="27986B5896684999" modified="2021-09-29" version="1">MKSRTSGGSRRGATGDTDGRSLEAALATSSLLLWLPYSLAAVYVAYCSAFVSELPPAGGFSALSSGGVSSVSASASRGGAGLATSSASAGASLAFSSALPMATVTHGDSIAGGGTTRPRYSVIYYYIFPLGFDIAVFLPLLLRVLSFSAAAILVTYYLSVHKYNGGEYLMAVAWALGTFSGYGWLYSSTGSVLPTSSSSSSASAGAQVASSAARPSWLWLVVSLLTGLFSGILCKVKDIVDGKHARNTHLFLLLDRYDEVVEDAGMCRPASVGNNYRDNSHPGSPFAAGTAPAYSPPYELPRYRRIRMSTSHHLVSLGDRLYMVVPFCTGQWFSFIIHHGWRGIIVENGTILLSLGLVGYTMLSYKFLKRQVLRVSGRVSLSATARSRSRRNKLRLQEEQQQGGAGVVSDREAVEDPDGVAFLEDVGEVAVVDVIDLISKLFTTSFGVVVLVVLGLNLFMTSLCIPFLKALFKLNALVSGVGIVIELIMYEVA</sequence>
</entry>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000003">
        <property type="protein sequence ID" value="KAG5488053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="SMR" id="A0A836I509"/>
    <dbReference type="GeneID" id="92364081"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="339"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5488053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="452" mass="47091" checksum="5C413C63DAF5E182" modified="2021-09-29" version="1">MEVLSDAAPITNGEVYALLRRRRDERNAARHPPFGLQPALADSQQRAAVATGTAAVASIAPSAAASVSAVSGAASVLSSKSSKAVPAGAIESASAVAAASTTNLLASPSSRHLVVLLTEVTMLNYLANHSALLLEPTTPPPTGTRVRTCTPRDLYGPTSVYNRAVGTWTAGSTVSRPGAVVGASKTSADALVDTEIVSSCYAKMAAHRPGTRGHVRGVSKLLEHFEEAGRAQERFYATGVRRAVQQLWRRRLWLPAGGPYPPSSVSSAAAAPVLRNGTALVKAEPVAEEDVAGTTEAPQRSSLTTEHLASSAAATTAASQDRVARRSAAEEANSGAEGARSTIVLRPLEPLLLEPTPLWGPAARCCGGKGSADAGATTVGAEHSPLSYRDQLQVQQASRSLLSEAEVLQLVVGRPQRALDVYRLLDDVDDRLHYSEEAVSAFVEALTAVFAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836K695</accession>
    <name>A0A836K695_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">LSCM4_00069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058260.1">
        <property type="nucleotide sequence ID" value="XM_067202159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836K695"/>
    <dbReference type="GeneID" id="92356093"/>
    <dbReference type="KEGG" id="loi:92356093"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5464629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="268" mass="28644" checksum="B97E3345384573AD" modified="2021-09-29" version="1">MRQCCRLLADSGSIATASASGHMISLREATRLAKSAGCFDTATGSSSSLLRRSTDPISTEDHSAANPAISWDVIKRRQHQLFRERHTTAQNNIAVTVSCVNMAHLSVYVHSVQCGYPASHAPGPSGEGVPGKRTITTTTLATQSCAVLLLSVSMESPGWLAVRCALSPGAMETCWRAAPTSASGRAAKVGRASEAAAPSATMSETEKLRRIKAWAEELALHRWVMASGQLRMEDVYDGDLQKVVTVPVLEVAMDNFKGSVRPLPRVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836K984</accession>
    <name>A0A836K984_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01061</name>
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    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
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            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059776.1">
        <property type="nucleotide sequence ID" value="XM_067203126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836K984"/>
    <dbReference type="GeneID" id="92357060"/>
    <dbReference type="KEGG" id="loi:92357060"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5467974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="814" mass="85440" checksum="8CAA87C7D17D6FD8" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836K9B7</accession>
    <name>A0A836K9B7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_01168</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Non-catalytic component of the proteasome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5468079.1"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
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            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR001213"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5468079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="220" mass="24775" checksum="7B03C1170981876E" modified="2021-09-29" version="1">MASGGSVIAIKYNGGVLMAADTLLSYESLAKWPNIPRIKLLGDYSAVCATGDYADFQMMAKEVEDSIERQKMYHNVDELCPSEVFSYLHRCIYRKRCDFEPCLCQMIFIGARDGKTFLAAVDDVGTRWEDDCIATGYGGHIALPLLRQALENCPGGLSRAAAEQILRDCLRVLFYRECRTINKFQMADAASDGVRISEPFHLETNWEHEGYCFEKTAIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836KAG4_9TRYP</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">LSCM4_00425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
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            <taxon>Metakinetoplastina</taxon>
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            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG5464977.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <location>
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            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="603"/>
            <end position="636"/>
        </location>
    </feature>
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        <location>
            <begin position="889"/>
            <end position="918"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5464977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1078" mass="113417" checksum="4D2E531AA905316B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KAM5</accession>
    <name>A0A836KAM5_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">LSCM4_00640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="GeneID" id="92356651"/>
    <dbReference type="KEGG" id="loi:92356651"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="DUF4515 DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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            <begin position="56"/>
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        <location>
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="634"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="246"/>
            <end position="358"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5465187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="678" mass="74191" checksum="02190696CE6DC820" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KBI7</accession>
    <name>A0A836KBI7_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="3" type="ORF">LSCM4_03055</name>
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    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Trypanosomatida</taxon>
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        </lineage>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067205073.1"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="2">
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        </location>
    </feature>
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        <location>
            <begin position="301"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5470359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="440" mass="47406" checksum="901AB54D3BBF5A14" modified="2021-09-29" version="1">MTTLPVLHLKATSKQNVTAAADLCDTTVTLYTFLRSIPSAAETERALQPFLASLHSTPSSGRASLMRRPNHHLVQRLESVAIDGVFRDTPHVLPALARHSDRWLRRLGYASVDDGIADSMAAMDAAGHAASGSPHLTSSAKAATEPLVHMRATDMHQYVDPYSAYEADYAQRHSAARSSPAGALAFDEANSSKNGSSEEASGLQRRGAAQPREEVSSVSAEVSALTVPGSESRLSEAGQSMLHGLSRAPTAAITSAPGIHPVLHLIAEQALQQQQEEEGVVEGRGMEGEKNQRGAPLSSSDAAVEEKLHQLAARLNEAEAQLTGVMSEKEAAEQVWSPYYSRLKTSMMYVEELKSRVQNAASLYLLLRYERETLQQAHLGVAMESMSLQLVLRDVQARLQDEQTHSLADGHQQSTEDHNLLQRISAALAASPAASRRSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KBP0</accession>
    <name>A0A836KBP0_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_00378</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
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        </lineage>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG5464930.1"/>
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        <location>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="150"/>
            <end position="162"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5464930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="176" mass="19322" checksum="40F7C2EF1A9F8089" modified="2021-09-29" version="1">MLSSSTGAAAKEDSVSLSTAVTTAEVDEDPNVEVLQVSKRIQRLTRATDALIARDFVLREEEVILDDLEAYLVSLESEVRRAELQTDELRSRCSLLRPSKRCAVAGENAELNALWNEYGETMGRLVRQHSLRLAELEKALTTLSARDSEPPSPKPLPPPPVARPSTTKATVRDAPT</sequence>
</entry>
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        <name type="scientific">Leishmania orientalis</name>
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        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    <comment type="similarity">
        <text evidence="7">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
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    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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            <dbReference type="ARBA" id="ARBA00022737"/>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="loi:92356679"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5465215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="119" mass="12723" checksum="934DEA5CC4F62FFF" modified="2021-09-29" version="1">MKGATASTDALVVPEAHAHQLLAAPRVALLLKEALLVKDGLAEVSRTNFLEVVHLHDFVLRLPEELLLCEARLTALARGLRAKCRVENGITAWLPTLQELVGLVPEEGVACAGASEKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KCQ1</accession>
    <name>A0A836KCQ1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Guanine nucleotide-binding protein subunit beta-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_02313</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="WD40"/>
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        <property type="entry name" value="Excision repair cross-complementation group 8"/>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051179">
        <property type="entry name" value="WD_repeat_multifunction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857:SF8">
        <property type="entry name" value="ANGIO-ASSOCIATED MIGRATORY CELL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857">
        <property type="entry name" value="MITOCHONDRIAL DIVISION PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
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        <property type="entry name" value="WD40 repeat-like"/>
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        <property type="entry name" value="WD_REPEATS_1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="WD_REPEATS_REGION"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
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        <location>
            <begin position="150"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="234"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="322"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="22"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="22"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5468921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="442" mass="47778" checksum="69DB3F259F994593" modified="2021-09-29" version="1">MSHHGRMFKVLDEDVEEAEDAFIDLEDPDVDILDESALPEEDGDDVSDANGDEAGMAAENKDNEEEGEGNRECSDPQRCTEVEDLNAAPDHVPERDDAFATFVAPERKPLHAIAVHPQHLCTFAVSGEGEEVYILELGDTAVAPVLKATLKGHTDTVSLLSFSPNGQWLASGSLDSSVVVWSTETWDRTYTLTDLCGEIMTLLWHPSSLILTAGADDAQAAMWNIVKGTLVMYFVGHRGAVTCTTWSPDVKKLVTGSADGTVGVFNPKTGEQEVSISKDLSPDNAGITALQYVNDDQCVVGCEDGTLHVISLRGGKVASHFEDLHEQAIESVAMSQSSLLLLTASCDCRVIVWNATDLSPRTILEVGESVIPAVWSHSHLIAAGCSDGEIRVWDGRSSQQEPLAVLMGHRRMILSLVTTSSVLASTSDDGTVKFFRFTETFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KCX9</accession>
    <name>A0A836KCX9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ankyrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_01380</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059125.1">
        <property type="nucleotide sequence ID" value="XM_067203434.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836KCX9"/>
    <dbReference type="GeneID" id="92357368"/>
    <dbReference type="KEGG" id="loi:92357368"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173">
        <property type="entry name" value="ANKYRIN REPEAT CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173:SF74">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="329"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="500"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="2104"/>
            <end position="2136"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="2219"/>
            <end position="2241"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="3475"/>
            <end position="3501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1835"/>
            <end position="1857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2432"/>
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        </location>
    </feature>
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        <location>
            <begin position="2570"/>
            <end position="2594"/>
        </location>
    </feature>
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        <location>
            <begin position="2669"/>
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        </location>
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        <location>
            <begin position="3714"/>
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        </location>
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        <location>
            <begin position="176"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1840"/>
            <end position="1857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="2669"/>
            <end position="2678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5466235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3742" mass="401592" checksum="88D7E3D7BA81BEA7" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KD51</accession>
    <name>A0A836KD51_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">IC97/Casc1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_01140</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNAI7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5468052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059854.1">
        <property type="nucleotide sequence ID" value="XM_067203204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KD51"/>
    <dbReference type="SMR" id="A0A836KD51"/>
    <dbReference type="GeneID" id="92357138"/>
    <dbReference type="KEGG" id="loi:92357138"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031826">
        <property type="entry name" value="IC97/Casc1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023247">
        <property type="entry name" value="IC97/Dnai7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20929:SF11">
        <property type="entry name" value="DYNEIN AXONEMAL INTERMEDIATE CHAIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20929">
        <property type="entry name" value="LUNG ADENOMA SUSCEPTIBILITY 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15927">
        <property type="entry name" value="Casc1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IC97/Casc1 N-terminal" evidence="3">
        <location>
            <begin position="37"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="28"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5468052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="689" mass="79309" checksum="F481635025975AFD" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KEQ2</accession>
    <name>A0A836KEQ2_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_03563</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061497.1">
        <property type="nucleotide sequence ID" value="XM_067205560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KEQ2"/>
    <dbReference type="SMR" id="A0A836KEQ2"/>
    <dbReference type="GeneID" id="92359494"/>
    <dbReference type="KEGG" id="loi:92359494"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF85">
        <property type="entry name" value="PALMITOYLTRANSFERASE HIP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="15"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="133"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="206"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="320"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="325"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5473494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="361" mass="40043" checksum="0F4B7384AC56DF22" modified="2021-09-29" version="1">MTDFPKLNRIKSDDENMERIHVAARKGQTDEVRRLIETGVSPIIQNRFGCTALHLACKFGCVDTAKCLASAGEVHTSWHGQKPIHLAVLSNKLDLVMALVEGAKERGQTPESLLNECDEREVSEVGCHVKHCKGQTALHWCVGLGPDYLPMIKLLVQLGASPTAKDKADETPLMRAMEFGHREALDTMLENVPNRNSLRLDYADKQGNSHLHWAILTNCEDVAIRFVELGIDVNMEDNDHTVPLYLSLRAAMVPLTKELLDRSDVFLIQACPYHNGTTVLPDRIAWLDFVPADADGAKQEVVRLLQEKLDEVARSLSAGVDGTAKKKKKKIAPPVKRMHLAPSAPVRTRSRSRARSSTVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KG73</accession>
    <name>A0A836KG73_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_03109</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060679.1">
        <property type="nucleotide sequence ID" value="XM_067205127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KG73"/>
    <dbReference type="GeneID" id="92359061"/>
    <dbReference type="KEGG" id="loi:92359061"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5471562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="158" mass="17791" checksum="2F1F8D9A57B2F897" modified="2021-09-29" version="1">MEKVLAYLQDTLLGQYLELVPSRWSALLPRLAKRTQRLQALADVTSISEVEKAVEDDFHLATQLLHAEHGIYHEGVALFDALSHTSDVMRHTWRLLAHDVLAELAAKEMILAHWKAAVATIAADTLRVYSHALLIHSRVTKARVHHLAELIRAEVRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KG79</accession>
    <name>A0A836KG79_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutamate--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Glutamyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LSCM4_02252</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Glu) + L-glutamate + ATP = L-glutamyl-tRNA(Glu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="3"/>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061322.1">
        <property type="nucleotide sequence ID" value="XM_067204285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KG79"/>
    <dbReference type="SMR" id="A0A836KG79"/>
    <dbReference type="GeneID" id="92358219"/>
    <dbReference type="KEGG" id="loi:92358219"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017102">
        <property type="term" value="C:methionyl glutamyl tRNA synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1160.10:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.800.10:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000037">
        <property type="entry name" value="Glutamine--tRNA ligase cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1160.10">
        <property type="entry name" value="Glutamyl-trna Synthetase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.800.10">
        <property type="entry name" value="Glutamyl-tRNA Synthetase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004526">
        <property type="entry name" value="Glu-tRNA-synth_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020061">
        <property type="entry name" value="Glu_tRNA_lig_a-bdl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049437">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00463">
        <property type="entry name" value="gltX_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF5">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20974">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="13">
        <location>
            <begin position="46"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding" evidence="14">
        <location>
            <begin position="354"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA synthetases class I (E and Q) anti-codon binding" evidence="15">
        <location>
            <begin position="460"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF20974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG5472926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="594" mass="67699" checksum="EDB8453843AA089E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KGN6</accession>
    <name>A0A836KGN6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RecA-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061424.1">
        <property type="nucleotide sequence ID" value="XM_067205487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KGN6"/>
    <dbReference type="GeneID" id="92359421"/>
    <dbReference type="KEGG" id="loi:92359421"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033065">
        <property type="term" value="C:Rad51C-XRCC3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:replication fork"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:resolution of mitotic recombination intermediates"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="RecA-like_N"/>
    </dbReference>
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        <property type="entry name" value="DNA REPAIR PROTEIN XRCC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46487:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN XRCC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00154">
        <property type="entry name" value="RecA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA-like N-terminal" evidence="1">
        <location>
            <begin position="276"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5473421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="645" mass="67199" checksum="96EF280916745B23" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KHY0</accession>
    <name>A0A836KHY0_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_04040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
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            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061967.1">
        <property type="nucleotide sequence ID" value="XM_067206030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KHY0"/>
    <dbReference type="SMR" id="A0A836KHY0"/>
    <dbReference type="GeneID" id="92359964"/>
    <dbReference type="KEGG" id="loi:92359964"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5474861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="122" mass="12964" checksum="5E441C9AAAFCEB8C" modified="2021-09-29" version="1">MNTTREKVTINFNTSRFGVKVADGSFDPDMTIGEVHARLRKKLVKAKAMTAPVASGGSEGAAAISTSSSTSGSGATFIFVRNGTEAFIPAPEQTLQTLLDMYATTPEVRKLYVTIDPEVFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KJ28</accession>
    <name>A0A836KJ28_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Haloacid dehalogenase-like hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_03887</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the HAD-like hydrolase superfamily. Cof family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061818.1">
        <property type="nucleotide sequence ID" value="XM_067205881.1"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A836KJ28"/>
    <dbReference type="GeneID" id="92359815"/>
    <dbReference type="KEGG" id="loi:92359815"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07516">
        <property type="entry name" value="HAD_Pase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000150">
        <property type="entry name" value="Cof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00099">
        <property type="entry name" value="Cof-subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47267">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47267:SF5">
        <property type="entry name" value="DEHALOGENASE-LIKE HYDROLASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01140">
        <property type="entry name" value="C2.B:_Phosphomannomutase_and_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01228">
        <property type="entry name" value="COF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5474712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="31180" checksum="6755B7DD54336DDC" modified="2021-09-29" version="1">MPIKAIVTDLDGTLLNPQHGISEYTASVLKRLKEKGIWLVVATGRPYADVFCRIRGCQLQPDYIITSNGARIHDGALKVVREHNMRPEIVEALARIRTVKDPVTGCELPKTFTTNIYRNAEWLTDKNIPEVSSAFHEDFRCTDLREGLYELKAEELHGVHEMWFIGDHDELVRLDNALDKDYPGDLCCTFSLPYILDCVPAGVTKGNGVREVAEVLGLTLDEVACFGDGMNDESMLQVTPTSFIMENGQQRLKDAVPHAQIIGTNADDGVAKKLQEMFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KJ76</accession>
    <name>A0A836KJ76_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_01960</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061036.1">
        <property type="nucleotide sequence ID" value="XM_067203999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KJ76"/>
    <dbReference type="GeneID" id="92357933"/>
    <dbReference type="KEGG" id="loi:92357933"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032860385" description="Transmembrane protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5472640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="23596" checksum="37D7C0EE40364233" modified="2021-09-29" version="1">MRRVYALLYAAAVMALAAASGHSSSSIQSHVPGVRHHPGGAGGSDGQGPTPLPASSGSLLMDDKSASVTMRFFISFMSVCAGSGLVALIVVLCAYCREYKLLETSSDSDTESVHSRATSHSSVSADSDSSSDLVQAYEAHRPQPIAPPPTAGEVMAAAAYEEANDETDLRRPVIQADTQSNEPHDFSVPADPTLGPSDDAATRIRFAGSRLSLASSRRGSYRRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KJE7</accession>
    <name>A0A836KJE7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_00959</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <location evidence="2">Coated pit</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059675.1">
        <property type="nucleotide sequence ID" value="XM_067203025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KJE7"/>
    <dbReference type="SMR" id="A0A836KJE7"/>
    <dbReference type="GeneID" id="92356959"/>
    <dbReference type="KEGG" id="loi:92356959"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030122">
        <property type="term" value="C:AP-2 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14833">
        <property type="entry name" value="AP2_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000010">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027156">
        <property type="entry name" value="APS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0168">Coated pit</keyword>
    <keyword evidence="6" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="11">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5467873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="143" mass="16768" checksum="CCB48FB6240CD163" modified="2021-09-29" version="1">MIHFILLQNRMGKTRLAKFYIPVDDAGQTKIKREVHVIVKARDTRSTNFVSYDDIKLVYRRYAGLFFILGIDQEDNDVMYVELIHLIVEVLDMFFTDVCELDVVFHFHKVFLIIDEMITGGEIQEVSRPVILSRLQELELSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KJF1</accession>
    <name>A0A836KJF1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transport protein particle (TRAPP) subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5478024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062931.1">
        <property type="nucleotide sequence ID" value="XM_067207363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KJF1"/>
    <dbReference type="SMR" id="A0A836KJF1"/>
    <dbReference type="GeneID" id="92361297"/>
    <dbReference type="KEGG" id="loi:92361297"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037992">
        <property type="entry name" value="TRAPPC6/Trs33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817:SF0">
        <property type="entry name" value="GEO08327P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5478024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="197" mass="22066" checksum="918AAB7719BC4462" modified="2021-09-29" version="1">MESKARSAHVSEAASSALTLEVVTHICSRRLKECTISDEQAAAEYEKDHFLERQGIIIGLRLMERLLYREPVFGGTPTDIVRYVGYTMWKAIFGKKVDSIKVIDSIYYLSDNDFRWLQGFPHLKESDRIQTLASSEGEGSKEGFAEELAGNVSHRDVLLYTVGIIKGATHSLLGEGNLTVTGTHTKEGETFFTLDFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KK92</accession>
    <name>A0A836KK92_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycine cleavage system P protein</fullName>
            <ecNumber evidence="7">1.4.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_04987</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 7">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GcvP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="7"/>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062265.1">
        <property type="nucleotide sequence ID" value="XM_067206962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KK92"/>
    <dbReference type="SMR" id="A0A836KK92"/>
    <dbReference type="GeneID" id="92360896"/>
    <dbReference type="KEGG" id="loi:92360896"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016594">
        <property type="term" value="F:glycine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00613">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000005">
        <property type="entry name" value="Glycine dehydrogenase (decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000007">
        <property type="entry name" value="glycine dehydrogenase (Decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000007">
        <property type="entry name" value="Glycine dehydrogenase (decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003437">
        <property type="entry name" value="GcvP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049316">
        <property type="entry name" value="GDC-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049315">
        <property type="entry name" value="GDC-P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00461">
        <property type="entry name" value="gcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003346">
        <property type="entry name" value="PRK04366.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773:SF1">
        <property type="entry name" value="GLYCINE DEHYDROGENASE (DECARBOXYLATING), MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="GLYCINE DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21478">
        <property type="entry name" value="GcvP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Glycine cleavage system P-protein N-terminal" evidence="8">
        <location>
            <begin position="28"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine cleavage system P-protein N-terminal" evidence="8">
        <location>
            <begin position="473"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine dehydrogenase C-terminal" evidence="9">
        <location>
            <begin position="795"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR603437-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5476032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="973" mass="106577" checksum="C170FEBC0E29EECE" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KLB3</accession>
    <name>A0A836KLB3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Temperature dependent protein affecting M2 dsRNA replication</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_05802</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPG/RAD2 endonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063505.1">
        <property type="nucleotide sequence ID" value="XM_067207732.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92361666"/>
    <dbReference type="KEGG" id="loi:92361666"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022039">
        <property type="entry name" value="MKT1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022040">
        <property type="entry name" value="MKT1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF28">
        <property type="entry name" value="POST-TRANSCRIPTIONAL REGULATOR MKT1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12246">
        <property type="entry name" value="MKT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12247">
        <property type="entry name" value="MKT1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Post-transcriptional regulator MKT1 N-terminal" evidence="5">
        <location>
            <begin position="873"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="domain" description="Post-transcriptional regulator MKT1 C-terminal" evidence="4">
        <location>
            <begin position="1115"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1080"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="176"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="289"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="349"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="409"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="437"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="459"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5479794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1366" mass="148505" checksum="F73C91E2E288788F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KLC2</accession>
    <name>A0A836KLC2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein RFT1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_04007</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8 9">Intramembrane glycolipid transporter that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. RFT1 could mediate the translocation of the cytosolically oriented intermediate DolPP-GlcNAc2Man5, produced by ALG11, into the ER lumen where dolichol-linked oligosaccharides assembly continues. However, the intramembrane lipid transporter activity could not be confirmed in vitro.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Endoplasmic reticulum membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the RFT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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</entry>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
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                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        </location>
    </feature>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KPQ9</accession>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Bates M.D."/>
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                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
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            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000015">
        <property type="protein sequence ID" value="KAG5483109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064605.1">
        <property type="nucleotide sequence ID" value="XM_067209222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KPQ9"/>
    <dbReference type="GeneID" id="92363156"/>
    <dbReference type="KEGG" id="loi:92363156"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5483109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="290" mass="33706" checksum="9BBFE2A5596AD7C6" modified="2021-09-29" version="1">MRVSPNSLSETASRLEQERERDFFRLLYIVDRARRFLAVPVSNVDWRLTCDCLDDMNHRYADTGFLLGFTGGYVLRNRSGRTLLSRFWFSMYLGLVLYDWELRRATRAPALEYWNSICTVDTEVGRIARVLHTPARFYEAAPMSEACSGVSVPRGSTLSSPSAPLGASMRDWFSRYTSEAISSVLLTTLLSHLLEGSSWRHRTSDNEEVTALMINNRFFRWRVFESRQVQRSETTEYNISLKWVPNFAASDSLRRSFQCRDLILERSTLGARLWYRMHFSLLRFLGLDSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KPR6</accession>
    <name>A0A836KPR6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_06539</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000019">
        <property type="protein sequence ID" value="KAG5480967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063968.1">
        <property type="nucleotide sequence ID" value="XM_067208456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KPR6"/>
    <dbReference type="SMR" id="A0A836KPR6"/>
    <dbReference type="GeneID" id="92362390"/>
    <dbReference type="KEGG" id="loi:92362390"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5480967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="310" mass="34722" checksum="80C6F1A768221BD6" modified="2021-09-29" version="1">MSGLPFFSLDDACDVEEGQGGEAVSRLAAGGDRGPRRSRLRRVRWLPHQRIVMLKEVDLWAEDSVTEGVHVVAERLWRARADASRDGRAQYLAEYLALHVDSPRHYQWLLSSYGPSLRDVLLTPSLAPFTEERCKGVLRRVLLALDQLHRVTMYVHADVSLGNIFTSTSCCDDVVLGDLESMSPIGAVPNRCLGSYLFMAPERLVDGALPLSPNDDVWAFGIACYGLLAWDVAHPWRVLATETDYSENYWAFLDLMSKAKDVPLSQLLMQSTLSRCSKEALAFVEVCLSWESTCRPSAAELLQHHWMLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KQE3</accession>
    <name>A0A836KQE3_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_07201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000015">
        <property type="protein sequence ID" value="KAG5482991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064487.1">
        <property type="nucleotide sequence ID" value="XM_067209104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KQE3"/>
    <dbReference type="GeneID" id="92363038"/>
    <dbReference type="KEGG" id="loi:92363038"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="598"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="736"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="601"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="613"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="627"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="656"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5482991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="777" mass="84727" checksum="A1C404F63A41EE39" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KQM3</accession>
    <name>A0A836KQM3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_03781</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNR ribonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061714.1">
        <property type="nucleotide sequence ID" value="XM_067205777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KQM3"/>
    <dbReference type="SMR" id="A0A836KQM3"/>
    <dbReference type="GeneID" id="92359711"/>
    <dbReference type="KEGG" id="loi:92359711"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022966">
        <property type="entry name" value="RNase_II/R_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF9">
        <property type="entry name" value="DIS3-LIKE EXONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01175">
        <property type="entry name" value="RIBONUCLEASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNB" evidence="3">
        <location>
            <begin position="304"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="839"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="844"/>
            <end position="854"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5474608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="939" mass="103990" checksum="FEA0E400587EE2BE" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KR64</accession>
    <name>A0A836KR64_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Leucine-rich repeat protein (LRRP)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_05726</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063431.1">
        <property type="nucleotide sequence ID" value="XM_067207658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KR64"/>
    <dbReference type="SMR" id="A0A836KR64"/>
    <dbReference type="GeneID" id="92361592"/>
    <dbReference type="KEGG" id="loi:92361592"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="504"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="516"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5479720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="571" mass="62241" checksum="6E0541849D0527B3" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KRC6</accession>
    <name>A0A836KRC6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-type proton ATPase proteolipid subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_05923</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Vacuole membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063626.1">
        <property type="nucleotide sequence ID" value="XM_067207853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KRC6"/>
    <dbReference type="SMR" id="A0A836KRC6"/>
    <dbReference type="GeneID" id="92361787"/>
    <dbReference type="KEGG" id="loi:92361787"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18175">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd18176">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000001">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011555">
        <property type="entry name" value="ATPase_proteolipid_su_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01100">
        <property type="entry name" value="V_ATP_synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0926">Vacuole</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032490157" description="V-type proton ATPase proteolipid subunit" evidence="10">
        <location>
            <begin position="21"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="150"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="307"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="11">
        <location>
            <begin position="37"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="11">
        <location>
            <begin position="116"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="11">
        <location>
            <begin position="194"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="11">
        <location>
            <begin position="273"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5479915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="344" mass="34710" checksum="CEA289427A8C3CA6" modified="2021-09-29" version="1">MKYQIASVVAAVAVCSGVAAVSCDDKYPQSAAFFGSMGCASALIFANLGSAYGTAKSGVGVAHLGILHADRIMRGIVPVVMAGILGIYGLIVSVIINNNIKTDDNSYSSFAGYLHFGAGLAAGLSSLAAGLSIGIAGDASARAYGKQEKIFVAMILMLIYQIASVVAAVAVCSGVAAVSCDDKYPQSAAFFGSMGCASALIFANLGSAYGTAKSGVGVAHLGILHADRIMRGIVPVVMAGILGIYGLIVSVIINNNIKTDDNSYSSFAGYLHFGAGLAAGLSSLAAGLSIGIAGDASARAYGKQEKIFVAMILMLIFAEALGLYGLIIALLMNNTAGKVTGGCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KSJ8</accession>
    <name>A0A836KSJ8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PUF nine target 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000011">
        <property type="protein sequence ID" value="KAG5485376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065113.1">
        <property type="nucleotide sequence ID" value="XM_067207939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KSJ8"/>
    <dbReference type="SMR" id="A0A836KSJ8"/>
    <dbReference type="GeneID" id="92361873"/>
    <dbReference type="KEGG" id="loi:92361873"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005077">
        <property type="entry name" value="Peptidase_C11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03415">
        <property type="entry name" value="Peptidase_C11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="582"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="600"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="630"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5485376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="647" mass="70860" checksum="88F8442AEB193E1E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KSS5</accession>
    <name>A0A836KSS5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_07878</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000013">
        <property type="protein sequence ID" value="KAG5484312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064805.1">
        <property type="nucleotide sequence ID" value="XM_067209755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KSS5"/>
    <dbReference type="GeneID" id="92363689"/>
    <dbReference type="KEGG" id="loi:92363689"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5484312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="498" mass="56109" checksum="85768362669876B6" modified="2021-09-29" version="1">MASGSVEFELLRGKNYPQSEDDPNPCTTQVAVAVVDALTGALISAAQLSSIQENSNAPFYNDTMSFRVEKGPEDICFSIKVSEHSRKEVPLVLFYGKQMIGLSKVKAKQRFVIPLFSEEEHTEQTEIGVDSLDLENSGTTPFLCARIHFTKDKVLDTTDPYSDVDVSNKHISLDGINQLVPEGTQYVWLRLKRDKNWTNSYQYELLVLWRSRGPLEVEAHTSTKPRKGPAGGMAATVAREQESTRTLGDIITKKWCCRRTHQVLTRVCMTAEKYGKKITDLTFTPKEEVEFRTNKKQRCVLLERICKNKLEDPGSSHLRDWLNRIWVLFVTGVDSDPAGPRVLSYEVRKAVHDAQFTEADAIILQACLLSSFIPSLKYETCQAISESDYRAAPPEKNRELTGFEASQCRVTPSQEQFTHVFVSFVGSLLETLTEAEIVKAAAEFKTAIWDAQQRIAKGAKNTIDSHRRNYDGSILKGNGIHINHLDKLGRRKQTPKFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KT48</accession>
    <name>A0A836KT48_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Intraflagellar transport protein A1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_04496</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">LSCM4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLUAP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062689.1">
        <property type="nucleotide sequence ID" value="XM_067206480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KT48"/>
    <dbReference type="SMR" id="A0A836KT48"/>
    <dbReference type="GeneID" id="92360414"/>
    <dbReference type="KEGG" id="loi:92360414"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019366">
        <property type="entry name" value="Clusterin-associated_protein-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21547">
        <property type="entry name" value="CLUSTERIN ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21547:SF0">
        <property type="entry name" value="CLUSTERIN-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10234">
        <property type="entry name" value="Cluap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="4 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="299"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="192"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="380"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="428"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="451"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="476"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5477278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="491" mass="54950" checksum="97BC3CCD702D2C89" modified="2021-09-29" version="1">MSFRELRSFSETMRLLGYPRLISMDSFREPNVELVADCLHWLIMRYEPSAEVTFNIEREHNRVTFFKQVCEIALAKGRIKLNVKKLYQADGHAVQEMLKLANVLKKAMKATDAEEPDFTALQQMAAQKNVSDAKAVQQLCSELTADGSSLFFLVEAELNSRGDRQRILSRATEVGEFERRLRELLTSVAQQVDQYQQSIINLSADESNLEQKIENKKAHLERAQKQYKSAMATNPAFLKEYENHEKKLQGQFVSYLEQYRNLEFLEHQVAKFNAKEDAMLEEQETKLKVMRERLRKEELKNIRADSSAHRPSGRHGTGDGGSLTPAMSDGEEDRYNYAPRVNGGVRIRNAAEEDSSGDESTSSGDESDSDDSRLRKQRAHQQQQQGRPQNAIGHSRAPLARGGAMSSDDGNHEEDDESFVSQLRRPRVAAGARPPAAGGERPRYPANNTADSDSSTSSSGSDSSELSTSTSSGEFSTDDASDYSGSDDSDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KU28</accession>
    <name>A0A836KU28_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_06650</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000010">
        <property type="protein sequence ID" value="KAG5485692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065276.1">
        <property type="nucleotide sequence ID" value="XM_067208565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KU28"/>
    <dbReference type="SMR" id="A0A836KU28"/>
    <dbReference type="GeneID" id="92362499"/>
    <dbReference type="KEGG" id="loi:92362499"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46754">
        <property type="entry name" value="MKI67 FHA DOMAIN-INTERACTING NUCLEOLAR PHOSPHOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="156"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="39"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="312"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5485692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="384" mass="41293" checksum="C080C460D6F5F794" modified="2021-09-29" version="1">MPLKSALKKVSSAAATGKRKKLSFAESAVKAAAAAIQTTHVNVPVKTAAAHPPAATTRQKKGQQASAATKTASSAAKKRAAADMKRSGIVKANRSEDEAAAPPAPSDEEHSSDDEDDMLNGDAAANWEADDLSDRADRSATTPRQRDSNGTVKPYRAVRLSFLPPEFQEPQLYKFLNQFGAAVLNCFCVRSKRSHRSRGIAYVEFDKESVIPLVVEECNGMALGGMSVRARAVTMRRPMPSRQMVNRRRALAYAYKTMGSPLKKHDVRRKDSVALLIKAARTESENNKYLQSLGIDFETDFFKSQLAALPPGLRKKKRSASRKPTNGAGSAAGTAKAVVTTTDVAVEVPKPSPLASREAPARKSVAKKVARPAVKKRVSAKKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KUB2</accession>
    <name>A0A836KUB2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_04711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000023">
        <property type="protein sequence ID" value="KAG5478478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063139.1">
        <property type="nucleotide sequence ID" value="XM_067206692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KUB2"/>
    <dbReference type="GeneID" id="92360626"/>
    <dbReference type="KEGG" id="loi:92360626"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF251">
        <property type="entry name" value="EG:BACR7C10.4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="22"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5478478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="462" mass="49216" checksum="2FFE0FF4C282456C" modified="2021-09-29" version="1">MDPAVKAAGELNAIFGRLGVLCKVCVTSEEGKHVRATEDLEEGFSLVEELPVVSWPSPSLLALSIPFCFQCLRLSSHQLSAAVPDSVTPPATVSAPLRSAPGAAPLPKSWSQCAQCASYFCSPECQQASARLHCLLCSCLSVVREGHCGSGGSSGAEVVTSKAAESISSAASLLTSSSTSSEITLEALARCVAWITHRLSSVIEQQQLTHEALQADYALQQRQAAGSASRAAWSTASLNYQLFTQVVTPFSRLVSPPDDVEFHGVSLGSWMAKLRFLLADRCVEQLLLASGASLRAVQRHTVAFDEDQQQQAVPAPALLWAEALVQVLLRTDTLRTLVGQMVLNAHAINDYVLPPGGDSSTGVFDWILKGAGLYSLLACFNHSCVPNAAVSAVDGTHEIVLKTTRPVRGGEPLTITYIPLNAGASTHAERQRQLRNYFFTCHCARCAMEGATATESSSTMSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KW78</accession>
    <name>A0A836KW78_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000020">
        <property type="protein sequence ID" value="KAG5480353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063684.1">
        <property type="nucleotide sequence ID" value="XM_067208044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KW78"/>
    <dbReference type="GeneID" id="92361978"/>
    <dbReference type="KEGG" id="loi:92361978"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5480353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="253" mass="27241" checksum="8E6DFA8F60C57AC7" modified="2021-09-29" version="1">MDIKSTLQPTRGCKAPLSRRDIHDELGVALTSASGSCSGAAHHAVASVCAPSALPRTAGNGLATDTPAVIPGADRTNWGSRVLKRLPHPQATLATQNVPRCGGLHRRIALSMESVLSWEDDTAVTSASEAECRCHTSTRSNPVHASATLHMCHECAAEEPATHYTGRRDGTEEDSTSESLFSRLDERLTRARRRNRARALSSCSNTAALSQESTGVSAGNRRRVRPRQLRSQLVEELVASDSVIDLLNEDWPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KXV3</accession>
    <name>A0A836KXV3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Fatty acid desaturase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_06373</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000007">
        <property type="protein sequence ID" value="KAG5486905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065699.1">
        <property type="nucleotide sequence ID" value="XM_067208294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KXV3"/>
    <dbReference type="GeneID" id="92362228"/>
    <dbReference type="KEGG" id="loi:92362228"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03506">
        <property type="entry name" value="Delta6-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353:SF88">
        <property type="entry name" value="DELTA(5) FATTY ACID DESATURASE FAT-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="FATTY ACID DESATURASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015921">
        <property type="entry name" value="FA_sphinglp_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="9">
        <location>
            <begin position="135"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5486905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="417" mass="48313" checksum="45A41E9AA7837760" modified="2021-09-29" version="1">MVLGDFLPHQPNEVLIDGVLYDCTNFLHPGGSILKYYLGSGDATETYQQFHFKLPRADQFLKRLPHRPAPPQLGVDVGEQKRLAKLSRDFKALKDACVKEGLFDANWPHIFCRFSELILMHCIGLCMLFRLPVLWPIALAILGVAQGRCGWWMHEAGHYSVTGIRWLDIKVQEVLYGLGDGMSASWWRSQHNKHHATPQKHRFDVDLETLPLVAFNKTIARRGRRNMNVRRWVSLQLYLFGPVTCSLVALYWQLFLHMRHIMRARRYTEGVAILCRWIAVGVICHNLRVSFWQGLGGVLFAQAFSAAYIFINFALNHTHLPMLPEDRHAHFVEYAAIYTMDVTPSWFVTWFMGYLNFQVEHHLFPSMPQFRFVQLAPRVRQLFEENGLKYDSRPYMKSLQATFKNLGDVAEFMVTGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836L0V4</accession>
    <name>A0A836L0V4_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_07671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000012">
        <property type="protein sequence ID" value="KAG5484898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065010.1">
        <property type="nucleotide sequence ID" value="XM_067209550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836L0V4"/>
    <dbReference type="GeneID" id="92363484"/>
    <dbReference type="KEGG" id="loi:92363484"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36219">
        <property type="entry name" value="WW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36219:SF1">
        <property type="entry name" value="WW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5484898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="439" mass="50906" checksum="B840E4B55DB119BB" modified="2021-09-29" version="1">MLRSTSGKLFRATPLLRVWAAEEDDPSAPPTTFKNVKPGRLLRLWRQIRHRAWILYTWDEEWISPIQEGYLHQQRLEQVCFAPLSAYGMVPGSYCDPLLYNTKNTSPFRWHVANVHSDIVGHWYMDADELFRIKDWQPKNPDDPLEMFPRPPQMLLKWDESVDEHGNRTFRYKYNYDMMGPTGKWEAYPRYPFSHLYLGGPDQHGRAEGYGFKQGHLLRCNEEEEEVLRRIMEEEDKEWEMVKRTEVVQEPWSYPGKIRPRDFEGAVERAKARFREQIRHGKETDPSEDAEYDLVQAGEYVEPRDGPRAEWRHLWTSNRKPGEPLPFQVTFNDGLRFEDNEGRPPVHPAAHFEERPKEAPYKTYEDADTAAARAAEEAEKAAREKSFKEAMERHRLLFGDTSGKPSGPPAPLPTGCPPMKDAASSPPPSGSNPSSPPNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836L3R8</accession>
    <name>A0A836L3R8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_08013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000005">
        <property type="protein sequence ID" value="KAG5487568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065856.1">
        <property type="nucleotide sequence ID" value="XM_067209889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836L3R8"/>
    <dbReference type="SMR" id="A0A836L3R8"/>
    <dbReference type="GeneID" id="92363823"/>
    <dbReference type="KEGG" id="loi:92363823"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000112">
        <property type="entry name" value="NUDIX hydrolase dihydroneopterin triphosphate pyrophosphohydrolase/hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114:SF17">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5487568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="179" mass="20324" checksum="470413FFBBF00935" modified="2021-09-29" version="1">MYRPNVCVFLFNENVEFLGCQRMKTDHFQCVQGGIETCDVDIMLAALREVKEEIGLKPEDLTFVQEISPPNGDPMSFAYTLAANANLRRFGYVGQKQRILLFFTPSENISKVTLIPPPELNASQEFRRVEWMPIEQLIAKSLPEKMHIFKAVGEVAPDIARAFLKKKGLVAEPKESAKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FZA4</accession>
    <name>A0A836FZA4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enriched in surface-labeled proteome protein 18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_00066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058257.1">
        <property type="nucleotide sequence ID" value="XM_067202156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836FZA4"/>
    <dbReference type="GeneID" id="92356090"/>
    <dbReference type="KEGG" id="loi:92356090"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5464626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="22123" checksum="F769906DA8B69036" modified="2021-09-29" version="1">MPRHRETTFHARFHFSRYWFTAVVAVLLYLSLSGGSLAGTRVSDDHFGSAAKSGASRTLASAAAAAPMSLQDACHTEMKLYCMEYQTSPLRCLVEQYDRTVSGNSEEQRRLTSALYSDMCESWLAARKACLDFVHTRGRGLCGLAVQDARECLRQIPPLVLPHACVTSAYYESVRLVGKLRQHQNADARLRLLREIPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G0I7</accession>
    <name>A0A836G0I7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GPI mannosyltransferase 1</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">GPI mannosyltransferase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_02120</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Catalytic subunit of the glycosylphosphatidylinositol-mannosyltransferase I complex which catalyzes the transfer of the first mannose, via an alpha-1,4 bond from a dolichol-phosphate-mannose (Dol-P-Man) to the glucosaminyl acyl phosphatidylinositol (GlcN-(acyl)PI) intermediate to generate alpha-D-Man-(1-&gt;4)-alpha-D-GlcN-(1-&gt;6)-(1-radyl,2-acyl-sn-glycero-3-phospho)-2-acyl-inositol and participates in the sixth step of the glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the PIGM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061193.1">
        <property type="nucleotide sequence ID" value="XM_067204156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G0I7"/>
    <dbReference type="GeneID" id="92358090"/>
    <dbReference type="KEGG" id="loi:92358090"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990529">
        <property type="term" value="C:glycosylphosphatidylinositol-mannosyltransferase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051751">
        <property type="term" value="F:alpha-1,4-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:GPI mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007704">
        <property type="entry name" value="PIG-M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12886:SF0">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12886">
        <property type="entry name" value="PIG-M MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05007">
        <property type="entry name" value="Mannosyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 11" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="160"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="274"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5472797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="432" mass="49287" checksum="95F0D871ED41CBDA" modified="2021-09-29" version="1">MSSATWMDRQSIRALLLYGGLVRLVLLIYAAFHDHYFRVKYTDIDYMIVVDGAREVLHGGTPFDRTTYRYTPLLAVLVLPAVLIANPLGKIIFTLSDLGAAYYCFRILLRFSTERSAKWMATVLILLNPVVLNVSTRGNSDMLISFMSMGVLAKFAEGRYFMAAAILGFAVHFKIYPVIYTLPLALGVWERAKPHRFFSRLAHTAPVVVGCGLCFMAAFAVPTYVCYMVYGQQYLDEAFIYHIHREDHRHNFSPYWLLMYLNMGRRDLGVGVDYSPGLFAFLPQFAVLLYASWKLRKNIAHAFCIETILFVAFNKVCTVQYFVWFLPFLGFVFCEPTPPKRLARTPIAPESEGPPLLRSVAVVLLWSLTIPLWVWTAYPLEFEGKNHYGRLWIVSCLFYLATVGLAAWLGRRCCRTNVTFSISDVGSLRKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G1V5</accession>
    <name>A0A836G1V5_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_00034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058225.1">
        <property type="nucleotide sequence ID" value="XM_067202124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G1V5"/>
    <dbReference type="GeneID" id="92356058"/>
    <dbReference type="KEGG" id="loi:92356058"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5464594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="152" mass="16764" checksum="9E5FFC81643C4B09" modified="2021-09-29" version="1">MEECDGDLSRVNPELLKLCASPEDWREQRRRAMKAKIFGTGTQVSASSTTEAYLPVDRTAGSPPSSAPQPFASSFTGQQAPASQQAAESYILQQILSHKRRREEANNSHVNTPANAPQPHTQRSVTPQQQPAASQSDGLSLKEKLMRKYKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G4A7</accession>
    <name>A0A836G4A7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_00551</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058730.1">
        <property type="nucleotide sequence ID" value="XM_067202629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G4A7"/>
    <dbReference type="SMR" id="A0A836G4A7"/>
    <dbReference type="GeneID" id="92356563"/>
    <dbReference type="KEGG" id="loi:92356563"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000216">
        <property type="entry name" value="Kinesin-like protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF15">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="8">
        <location>
            <begin position="9"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="433"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="558"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5465099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="625" mass="70936" checksum="423C297A5CA1E873" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G4T6</accession>
    <name>A0A836G4T6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_01450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059194.1">
        <property type="nucleotide sequence ID" value="XM_067203503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G4T6"/>
    <dbReference type="SMR" id="A0A836G4T6"/>
    <dbReference type="GeneID" id="92357437"/>
    <dbReference type="KEGG" id="loi:92357437"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18316">
        <property type="entry name" value="BTB_POZ_KCTD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499:SF143">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499">
        <property type="entry name" value="POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="201"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5466304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="471" mass="52542" checksum="2A4AB0C9093433E9" modified="2021-09-29" version="1">MPPTAFERGNGERGAQHTVSGRRPQRGGRKRARDTTSITPASLLVESADAPPDQALTTAASVAAPENDGVDNVPDHSSASPTPAGRDSVRDPRSATSSVADRREEDSMDDDSDPTGLVRSVTSSAFSPSDAAGHMPDEEKAARLLQQSRGAAQSIQAQVESCVSRFKLMEAHLDTLLKERQETKPKLEEVAQSRHLERYMEVVSLSVGGERFTVPLSTLLSKDAPNYFHVLLGSEETGWVAPVFKDEHGTIFIDRDPACFKYILDYLRGYHYFNLLKEDSLRRLKVDAAYYQLPGLLAMLGDVDRDTELQFSPGPGVSPERNRLRVVYGVAVVGDVSLVTGRHAITYEVKVADYVGFGLISESCVNTDQEFHKIPDCCVYYMSGVFYTNYPYHRKEENLERIENGDFVTVKVDLEKGYVEYVLKNSRKMVSLGRARRLRFATTMKLASRVRIVPPEEVRRRLSPIHYSFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G5P0</accession>
    <name>A0A836G5P0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_04229</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MICOS complex subunit Mic10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062155.1">
        <property type="nucleotide sequence ID" value="XM_067206218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G5P0"/>
    <dbReference type="GeneID" id="92360152"/>
    <dbReference type="KEGG" id="loi:92360152"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007512">
        <property type="entry name" value="Mic10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21304">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21304:SF4">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 21KDA SUBUNIT N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04418">
        <property type="entry name" value="DUF543"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5475647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="109" mass="11633" checksum="D7EBB414743AFA03" modified="2021-09-29" version="1">MMSATPKQASPATASISSDEKWDHSLETLIRKSTIGLAIGILPGLLLARSPAARSAIIALCTGVGTGIAYGEARYLFDHDIMFDKRHLIQVQMVGSSSTQKSDARKSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G5U3</accession>
    <name>A0A836G5U3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein 107</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_04322</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062245.1">
        <property type="nucleotide sequence ID" value="XM_067206308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G5U3"/>
    <dbReference type="GeneID" id="92360242"/>
    <dbReference type="KEGG" id="loi:92360242"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032741424" description="Transmembrane protein 107" evidence="2">
        <location>
            <begin position="19"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5475737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="113" mass="12742" checksum="812361B4EC6A6EDD" modified="2021-09-29" version="1">MLYIVALTLLTFASTFMAADTVANIWQALSRGRVALISYSVWMAALTLTVLGTDWLTTLGFVHTLIFVACWWLVRDGDDAAHSSSTFDDYVRFPMTVYVPAFMALYFLQGWLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G8G6</accession>
    <name>A0A836G8G6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arf-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_02795</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060367.1">
        <property type="nucleotide sequence ID" value="XM_067204815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G8G6"/>
    <dbReference type="SMR" id="A0A836G8G6"/>
    <dbReference type="GeneID" id="92358749"/>
    <dbReference type="KEGG" id="loi:92358749"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030100">
        <property type="term" value="P:regulation of endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08830">
        <property type="entry name" value="ArfGap_ArfGap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46395">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46395:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="13"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="334"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="357"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5470101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="403" mass="43492" checksum="D8F432E5866D456A" modified="2021-09-29" version="1">MTNRTYVSPEDAQAFASILAKDPECKWCFECGAPSPQWCDVMHGTFICLNCSGQHRGLGVHLSFVRSSTMDGWMNWKPEKLRQMELGGNRRARLYFEAHKIPKTPLRDRYESLPALRYADMLESEALGKPFNEAAWQPPAWYTRLKAAANPSGPSPTSAYPQTDPSRFAGVGSNGQPHVMPGNSGGSSDWYSTLYSGWSTVSQKTAELAQHATKAVQSADVEGMRSSLAQKWADVSATVSTYATDLQQRMAEVGGRKNGPGDHENDGFACMIQNARQAQAESVGDTLRPGNNRYDHVESNSGFATVPRASVYERPVGATSPVASTVYQGVVVSQAASSRPPTCRAPASTPAGWGSPTRVSPSSTLPQTEPRSSRPANPLGGGGGTTAPQSPKKGEWAWDDENF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G8Y8</accession>
    <name>A0A836G8Y8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinetoplast DNA-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060637.1">
        <property type="nucleotide sequence ID" value="XM_067205085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G8Y8"/>
    <dbReference type="SMR" id="A0A836G8Y8"/>
    <dbReference type="GeneID" id="92359019"/>
    <dbReference type="KEGG" id="loi:92359019"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052695">
        <property type="entry name" value="Kinetoplast-DNA-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37564:SF4">
        <property type="entry name" value="DNA-ASSOCIATED PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37564">
        <property type="entry name" value="KINETOPLAST DNA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5470371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="146" mass="16864" checksum="756DE717C9790C6C" modified="2021-09-29" version="1">MLRRCLALRRVSPFSIFQKHLGETRVLKGIKNPTRKSAQMYRQLSTPERKIFEERARRVSYPALDAYNRFQKEYAPRFMHLPMKQRQRKVAQLWAGLKENGTVKIPKGATSKVKKVAKKMKAKRSVPRKASSGGKKPAKKGSKKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GBJ0</accession>
    <name>A0A836GBJ0_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060036.1">
        <property type="nucleotide sequence ID" value="XM_067204484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GBJ0"/>
    <dbReference type="GeneID" id="92358418"/>
    <dbReference type="KEGG" id="loi:92358418"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5469059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="565" mass="60139" checksum="CAC0ADDE789AAE75" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GBL6</accession>
    <name>A0A836GBL6_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_02501</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060081.1">
        <property type="nucleotide sequence ID" value="XM_067204529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GBL6"/>
    <dbReference type="GeneID" id="92358463"/>
    <dbReference type="KEGG" id="loi:92358463"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36960">
        <property type="entry name" value="SI:DKEY-32E6.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36960:SF1">
        <property type="entry name" value="SI:DKEY-32E6.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5469104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="405" mass="46029" checksum="3ABA0DEF3A890271" modified="2021-09-29" version="1">MRTNVMSRELLQQCSKKHLVIHMDINKTIIQVDQAGGRTMDDVLNNNVAANTFGIVDTTDNQWRPLYSAYDFPVAPPASTSGPIMSYDAYIDRLHCAPLGMQNLPKEERDAVWKSVSNCRRQATRKFTFPGEVGEPYAPLVDLQRQHLQHRDGYYNIIPAFFHMVNTLSELDFRFTLIFRTFGSDLDTVLQEWRSFVLGTHVCKPSGPVLRRLKENYIEPLSGSFFRQGDAIYVCHGPRVSLSSYLTSGFEETDPDKVLEHLHQVPGCTSACKATFADLKDHLVEYFARSQNVGGLVDYYPTWAQSAEHRTGGKVFPVSQNDPNYYFVFFDDNIFIGDEHSIVDIRAADGAKSLVDIEIEKKYCVPVNAFKAILDKEYFVNELCECLRLQDSEVSLGEVQLLRSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GC66</accession>
    <name>A0A836GC66_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Guanine nucleotide-binding protein subunit beta-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_01869</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000022">
        <property type="protein sequence ID" value="KAG5479277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063370.1">
        <property type="nucleotide sequence ID" value="XM_067203911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GC66"/>
    <dbReference type="SMR" id="A0A836GC66"/>
    <dbReference type="GeneID" id="92357845"/>
    <dbReference type="KEGG" id="loi:92357845"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="6"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="59"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="180"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="367"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="408"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="298"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5479277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="452" mass="47242" checksum="81A210F3019B68D3" modified="2021-09-29" version="1">MFTQLSSAHTEVVTSLTFSPHVITTGEGGLLCSTSGDDTAALWDLRAGPGASQRAAHFTGHHLGPVNHALFHPDNPYTLLTASDDRTIGCWDLRRPDRVIGKICGFQEGVNKMLWLPVTSTGCGGTEGRSSGRWSVVSACDDGHVYVHALVLPDCGAESTADAGTNPAPIPQVGALVDKFRVSTSTVNDIVLAPNSTSILITASEDCALRSWSLRHAQQMTNTSAGLMEDRLLASLDEFENPVNHVVVVPRGLMAPLESQAAGGGPESVNGRSPAGAADDAEECAGAAVASTGFARAYQPAHDGDSSEDDEAGSGAGSSAGAPRRRPLEISEASGTGCWLLAACSECVFGVDFAVRLGEFGNGVRTFVGHQDYVRGLEFTSDGKLLTVSDDSTAIEWSLATTAPIRQVKLHEGLVMSSAVSPSLTLLATGTDCGEIRVWRLPFATERIGGSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GCM5</accession>
    <name>A0A836GCM5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Fructose-bisphosphate aldolase</fullName>
            <ecNumber evidence="4 8">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_00127</name>
        <name evidence="11" type="ORF">LSCM4_00128</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">LSCM4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the class I fructose-bisphosphate aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="4 8"/>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058318.1">
        <property type="nucleotide sequence ID" value="XM_067202217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GCM5"/>
    <dbReference type="SMR" id="A0A836GCM5"/>
    <dbReference type="GeneID" id="92356151"/>
    <dbReference type="KEGG" id="loi:92356151"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00948">
        <property type="entry name" value="FBP_aldolase_I_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000140">
        <property type="entry name" value="Fructose-bisphosphate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029768">
        <property type="entry name" value="Aldolase_I_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000741">
        <property type="entry name" value="FBA_I"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033379">
        <property type="entry name" value="FrucBisAld_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11627">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00274">
        <property type="entry name" value="Glycolytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00158">
        <property type="entry name" value="ALDOLASE_CLASS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5464687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5464688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="372" mass="40835" checksum="7822A7BD366DF172" modified="2021-09-29" version="1">MSSRVDVLSCQLPAYNRLKTPYEQELIATVKKLTSPGKGLLAADESIGSCSKRFDPIGLSNTEEHRRQYRALMLEAEGLEQYISGVILHDETVSQKASNGQTFPMYLTGRGVVPGIKTDMGLCPLLEGAEGEQMTEGLDGYGKRASAYYKKGCRFCKWRNVYKIQNGTVSEAAVRFNAETLARYAILSQMSGLVPIVEPEVMIDGKHDIETCQRVSEHVWREVTAALQRHGVVWEGCLLKPNMVVPGAESGKTATPEQVAHYTVMTLARTMPAMLPGVMFLSGGLSEVQASEYLNAINKCPLPRPFFLSFSYARALQSSALKAWGGKESGIPAGRRAFLHRAKMNSLAQLGKYNRADDDASSSSLYVKGNTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GDD3</accession>
    <name>A0A836GDD3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tyrosine phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_02773</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060345.1">
        <property type="nucleotide sequence ID" value="XM_067204793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GDD3"/>
    <dbReference type="SMR" id="A0A836GDD3"/>
    <dbReference type="GeneID" id="92358727"/>
    <dbReference type="KEGG" id="loi:92358727"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14501">
        <property type="entry name" value="PFA-DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000187">
        <property type="entry name" value="Tyrosine phosphatase family, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020428">
        <property type="entry name" value="PFA-DSPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004861">
        <property type="entry name" value="Siw14-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF58">
        <property type="entry name" value="TYROSINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03162">
        <property type="entry name" value="Y_phosphatase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01911">
        <property type="entry name" value="PFDSPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="203"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="399"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="215"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="252"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5470079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="422" mass="46660" checksum="789F7DF912A962CB" modified="2021-09-29" version="1">MASSSKGGGAVLVPPLNFAMVEDGIYRSAYPTEANVLYLRHIGITHIVLLSIEQLPGPVKRLLGSEVTGKAASSCLTRGPIRIIDAVDMHTWCVDGTNSGDDFSRRDVTRALDFAVDRRWHPVLFSCPLGELQTNVLIGCMRRYQHWALSTIFSECELYKTVCRTLRQSILLFIESWDPADHPISAVDMQYRNREMMMRERLRAQKERRRRRRAGASASSEGSRNRACGLGSVEETAEEEEEEAMPSGTSDLFDKNSLDGKHSSTVSSLQCGRSELSVASTPPAVDLRVLNPDAALISTSGQRPPMMVRRAAAARVREQQEQQLNNQASVSETEEQASSLQIGMGKVAGVMWAEWYLEALCVAEELKSRAYRLPTMGYGTIDAPLGAELPPPHVLYANARNPPALDSRSTFTKESIVEEDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GFG7</accession>
    <name>A0A836GFG7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_01668</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059407.1">
        <property type="nucleotide sequence ID" value="XM_067203716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GFG7"/>
    <dbReference type="SMR" id="A0A836GFG7"/>
    <dbReference type="GeneID" id="92357650"/>
    <dbReference type="KEGG" id="loi:92357650"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033550">
        <property type="term" value="F:MAP kinase tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017017">
        <property type="term" value="F:MAP kinase tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008330">
        <property type="term" value="F:protein tyrosine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF519">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE MPK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="207"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="7">
        <location>
            <begin position="279"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="53"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5466517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="365" mass="39901" checksum="74519A14D3CA510D" modified="2021-09-29" version="1">MDTRCCTPPSIGGAEDLCLASCRHQLFVNDEDDHEAENTALATSVTMRPSVSFPRLSQSYSSEETRPSNPLDANVELPSPARPPCSPRRAFHPIPINLPSDSCFGRTAFQGCSFEATASDGIAGTPWRPTTMPAQSNAAPAAAPAANTSMAHLQTPEVQRTNCAVATPSMIGYLLYTPQIPPACQEWRASLDAELDSVNRRWAPDQLPSLTALIDNALYVGGFPDAQTVPHLQALGIRHIVNCCAQDIHTAPEVAASFNLHHFESFDAEEYLILHRDYDAFAGLVSTILGNGEKVFVHCIAGVNRSVVLCAAYLMDRLSLNPVEAVRVFRANGRMRILDNKSFRYQLVDHYLQNVEPRNARLGLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GHV8</accession>
    <name>A0A836GHV8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_05560</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000016">
        <property type="protein sequence ID" value="KAG5482307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064313.1">
        <property type="nucleotide sequence ID" value="XM_067207499.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92361433"/>
    <dbReference type="KEGG" id="loi:92361433"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005216">
        <property type="term" value="F:monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006816">
        <property type="term" value="P:calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014821">
        <property type="entry name" value="Ins145_P3_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013662">
        <property type="entry name" value="RIH_assoc-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015925">
        <property type="entry name" value="Ryanodine_IP3_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13715:SF99">
        <property type="entry name" value="INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR-LIKE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13715">
        <property type="entry name" value="RYANODINE RECEPTOR AND IP3 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08709">
        <property type="entry name" value="Ins145_P3_rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08454">
        <property type="entry name" value="RIH_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="2400"/>
            <end position="2419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="2511"/>
            <end position="2537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="2575"/>
            <end position="2595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="2655"/>
            <end position="2674"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="8">
        <location>
            <begin position="79"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="803"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2771"/>
            <end position="2825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2867"/>
            <end position="2900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="805"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="2796"/>
            <end position="2810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="2869"/>
            <end position="2890"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5482307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="2900" mass="317796" checksum="5E84932AA929BCBB" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GID6</accession>
    <name>A0A836GID6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061160.1">
        <property type="nucleotide sequence ID" value="XM_067204123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GID6"/>
    <dbReference type="SMR" id="A0A836GID6"/>
    <dbReference type="GeneID" id="92358057"/>
    <dbReference type="KEGG" id="loi:92358057"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052578">
        <property type="entry name" value="PI_Transfer_CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824:SF29">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="75"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5472764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="292" mass="32695" checksum="4654734B579F2370" modified="2021-09-29" version="1">MATAKSTSKEAACVAALKDKYPAAQADPADAGFLNERTYIRFARARDSDAEKAAALLGAALKWRQQTEPYAITAEEVDKAMRQTTILCGGRCGNGCPVIAMVLGMQNECTVEERTKQLVYIMEETQRKGYDRITWIVDFGAMGNHRDERSREARKETMKIMRDYYPERMERILLYRAPWYIRMLLSVAKAFMDARTVAKITNAGCTIEELEKFIDRGQVPVVCGGTMKGSTITHLEELPYLDSEEAQRLGLKQDIVNADGDRAMLGNEAEKDPAAVNIEAERNIKMNSMNTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GJ34</accession>
    <name>A0A836GJ34_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_01530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059270.1">
        <property type="nucleotide sequence ID" value="XM_067203579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GJ34"/>
    <dbReference type="GeneID" id="92357513"/>
    <dbReference type="KEGG" id="loi:92357513"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5466380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="255" mass="27782" checksum="7ADCF3299F6A8ABB" modified="2021-09-29" version="1">MALDFDVDDAPTFDELVRDARHGVMQNREMAACWLELADQHTFFKNIAKEGRARGESLGAVLAAMQGICQAVQRVELSNSEVEAPSPACTAAFSSPARRLSGGSWPDSQLKETWALAQVVRAYLGLYCSTPIPTRAQWASSLQPLFPESTNEAIASRCTVDAGAVHPTPALSTLGRYLTQLRQTVGRVTQELPDSDSDEKDGSFAAEELKELVLCCIAVGRRVARSTTLPHLDARLVREMVTALQDFVGSSTLEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GJI4</accession>
    <name>A0A836GJI4_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_04063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061990.1">
        <property type="nucleotide sequence ID" value="XM_067206053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GJI4"/>
    <dbReference type="GeneID" id="92359987"/>
    <dbReference type="KEGG" id="loi:92359987"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5474884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="350" mass="37500" checksum="11F308657205A584" modified="2021-09-29" version="1">MRQASAMAFGDSAEALLGPPVMAPRERANSLTWLEAHAAVRLCTLTGKSFDCYGLPLRQSHKDRRARFSLIKSVKGLASHLTTRINPSFQECLIRVVESESDLTFEVRQLSGGNCARGQLLFAAPLTTLLDVVSDSVTERDTVIFAHLPSSFQPAAENSSYVAPVDASTNRRAPRTANTPRTTVPRKKIVSTLFSAYGDIGLDLVFRAAQADAVNLRRSSSSLSSVSHSAAASGSGAPYTRVRLRFVSTKERNAWLSFCAEAYLGLLLDSIRTDRDTVFVVDENDHPSLTAAASPSTTAVPRGDVLEIEKPTEEAVGCYIDFFLSVSAKGNTGGGSNGDATLLPCPRAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GJN9</accession>
    <name>A0A836GJN9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Casein kinase II subunit beta</fullName>
            <shortName evidence="2">CK II beta</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_00545</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the casein kinase 2 subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058724.1">
        <property type="nucleotide sequence ID" value="XM_067202623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GJN9"/>
    <dbReference type="SMR" id="A0A836GJN9"/>
    <dbReference type="GeneID" id="92356557"/>
    <dbReference type="KEGG" id="loi:92356557"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1820.10:FF:000011">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.20:FF:000001">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1820.10">
        <property type="entry name" value="protein kinase ck2 holoenzyme, chain C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016149">
        <property type="entry name" value="Casein_kin_II_reg-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035991">
        <property type="entry name" value="Casein_kinase_II_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000704">
        <property type="entry name" value="Casein_kinase_II_reg-sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01214">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00472">
        <property type="entry name" value="CASNKINASEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM01085">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57798">
        <property type="entry name" value="Casein kinase II beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01101">
        <property type="entry name" value="CK2_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="219"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="234"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="262"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5465093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="276" mass="31112" checksum="FBDBFC98595907AF" modified="2021-09-29" version="1">MDEAYSPETMEYEYEDEELVSWITWFCDLKGNEFFCTVDREFITDDFNLTGLAPIVPFYHYALELILDVESMESDGLTEQQKRLVESSAEILYGLIHARFITTGRGLKLMEEKYVQGEFGSCPRVFCEGHALLPVGQSDVVRESSVKLFCPRCEDIYHPRSVRHRSLDGAFWGTTFPHLLLMQLRERGVSIPPPNQQYVPKVYGFRVRKPGAPLIAKVADPEETSAAPAGAENASRKPEAAVYQKEEERALARSNVVDQRPSAESSTSSSSKAKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GKP2</accession>
    <name>A0A836GKP2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_04126</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062052.1">
        <property type="nucleotide sequence ID" value="XM_067206115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GKP2"/>
    <dbReference type="SMR" id="A0A836GKP2"/>
    <dbReference type="GeneID" id="92360049"/>
    <dbReference type="KEGG" id="loi:92360049"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002477">
        <property type="entry name" value="Putative replication factor C, subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000012">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000015">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001679">
        <property type="entry name" value="PRK00440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF5">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="38"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5475544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="360" mass="39570" checksum="EA832DBA3DF449F8" modified="2021-09-29" version="1">MNTASTPWVEKYRPQTVSDIVGNTEAISRLQVIAREGNLPNLLLCGPPGTGKTTSMLCLARDLLLQSTDTASVGSSPGGAMKDILKEAVLELNASDDRGLDVVREKIKLFAQTKKTLPKKYFSTGDGATREEQVVHLHKIVLLDEADSMTPAAQQALRRTMELHSSTTRFAFACNNSSKIIEPIQSRCAVVRFKKLSDADILKRLVYVIQQENVSYTDDGLEALLYLAEGDLRQALNALQATHTGYGLVNADNVFKVCDQPHPVLVENIITACITKRNIEEAHKEMNRLLNRGYAPVDVISTFFKVVQTNARLFRSELQQLEVLKIVGETTMRIAEGVGTSLQLAAMLARMINAVESAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GLU6</accession>
    <name>A0A836GLU6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_00981</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059697.1">
        <property type="nucleotide sequence ID" value="XM_067203047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GLU6"/>
    <dbReference type="SMR" id="A0A836GLU6"/>
    <dbReference type="GeneID" id="92356981"/>
    <dbReference type="KEGG" id="loi:92356981"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000086">
        <property type="entry name" value="Protein phosphatase 2C-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="6">
        <location>
            <begin position="161"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="96"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5467895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="450" mass="48093" checksum="348D0E989E5699A9" modified="2021-09-29" version="1">MPAEKKSDATATRRPESPHSSKSPTPASATTAFTTPKKKSIPRPKQKPPTAPMSKYSSTSSTPVGRHPNFLSAPTATTLSRPRDSPKFALSPEASPPSTGTDDGPAPQSSCDRGDNKDRQSSRVVVPSSMGATPPSRQNSATLNPLCRHASMRKTAFVVVDYGATAEQGARKTMEDQHTMLSEGIPFFGVYDGHGGTQCAEYLRDQLHGLILGHPEVKTNPEKAIVEGIIEADRAFLARSEAETNESGSVCAVALIIDDKLVVGNVGDAEVVLSRNAKPIVLTVRHNISSNPSEEERIRSVGGKVCHNRVGHPNYNPAVVSLAVTRAIGDAGFKLAKYTDGKPSGVIAVPETSVTRLTDEDEFLVIGCDGLWDVMTYAEVVDFCYHRLQEGVPAQCIAEELAQAALSKGSTDNVTAMLVHLTRREGPLSTREFVPEAAVSTSTRNLSEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GP80</accession>
    <name>A0A836GP80_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_02613</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060192.1">
        <property type="nucleotide sequence ID" value="XM_067204640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GP80"/>
    <dbReference type="GeneID" id="92358574"/>
    <dbReference type="KEGG" id="loi:92358574"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032991873" evidence="3">
        <location>
            <begin position="32"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5469215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="448" mass="45887" checksum="20EEB371525A5B2E" modified="2021-09-29" version="1">MDPLQRRRCGSHHGVTVLCVFLAFLFVLAAAHCTPAHAPHHMSERAEHESVALEKAVKHCAGSSFNDDKHVVKDFVFHDTDAQTGAASGISNTVTSAKSDEGFSSLETVDKPSVKSGPASSASASSAGVTTRSGSSGPVAGSRSSMSEPSSSASASSAGVTTRSGSSGPVAGSRSSMSGPASPAASSDSFAAYSSSDMEAGEPTESKESEATTTLTETTSTVSPTSASPTAKLPADDDGMGTAVVFLILIAFIVALAMYGGRFCPSKCPFFGQNRGGLDHGTRSPMQQQHPLYARLQGSNDGDRGMEPSYAATGAPAGGHKFGRLFQPLSGGGDSDPHHDLFVEMENKPSKTLRGSGVRLGGGATDSLNQVVAKKPAAVNEFLGNSVSSVCPVAVQIPQPSNNSLKSLRKGKLVHTPATTAGVLSSNAVAATASQTTTAPRVESEWKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GQZ7</accession>
    <name>A0A836GQZ7_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_02899</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060471.1">
        <property type="nucleotide sequence ID" value="XM_067204919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GQZ7"/>
    <dbReference type="GeneID" id="92358853"/>
    <dbReference type="KEGG" id="loi:92358853"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22968">
        <property type="entry name" value="DD_EFCAB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5470205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="125" mass="13829" checksum="FB81F0921537BB49" modified="2021-09-29" version="1">MSVSPQPEDDSALVVRLIEEGLFLNHIDMCNGSNGAEISADHRYLIENVFPTLVPALQDLIKMYRGQITPNDTGGSTANKAKADPVMWLAQYLLRNNVHSGTSRLAHHPFQTINKAALNRESTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GSD4</accession>
    <name>A0A836GSD4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000020">
        <property type="protein sequence ID" value="KAG5480466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063797.1">
        <property type="nucleotide sequence ID" value="XM_067208157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GSD4"/>
    <dbReference type="SMR" id="A0A836GSD4"/>
    <dbReference type="GeneID" id="92362091"/>
    <dbReference type="KEGG" id="loi:92362091"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="322"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5480466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="393" mass="43448" checksum="AF994CC143370DDE" modified="2021-09-29" version="1">MSCGTAQAEAATPPVSVQLTPIVPIRIFDAHGDYFDTEMDIDAPLRSLQLAIEDYFKVKPEVQLLLHNRQQIHPERSLRDNGCLLLKGDPYVKLVCLLKRGPVLNLRCEVGPVTHVIACHEMATVWEVKRMLCEEIERQQRRAAPTEGAARRLACGPERLRLLWRYMELNDKATLHYYRISTNAVLHVMHRRRASAPATAAASSPSNRETGLHRTVVAQQPSTTAWWQHPHAAPASPSSAACVAAVSPASAPEARVTHSPAEWHHDAFDATASPCQDLPIVSAYTQPPLSAPAAAPPMADYAQFAPGAPQQLPRDILMSSEVVTLSLAVRSLEAQLHSLRQEQRQVEQYQQSLTAYQRGSLADAQQRILELEETVKRFHALLQRAVALIPASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GVG2</accession>
    <name>A0A836GVG2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">rRNA adenine N(6)-methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_01940</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="7"/>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061016.1">
        <property type="nucleotide sequence ID" value="XM_067203979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GVG2"/>
    <dbReference type="SMR" id="A0A836GVG2"/>
    <dbReference type="GeneID" id="92357913"/>
    <dbReference type="KEGG" id="loi:92357913"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000179">
        <property type="term" value="F:rRNA (adenine-N6,N6-)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.480:FF:000010">
        <property type="entry name" value="rRNA adenine N(6)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000081">
        <property type="entry name" value="rRNA adenine N(6)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727:SF7">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 6 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA adenine methylase transferase N-terminal" evidence="9">
        <location>
            <begin position="85"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="309"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5472620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="374" mass="41097" checksum="3E31EF0E3722A52B" modified="2021-09-29" version="1">MPKEPRAVPMGIISAEPIHAASRKLKFGTKVVTLGRSSRQGHSHSAAVGGYKEKKAAAGVKTGGAQSGIVFNKGFGQHILKNPLVIAAIVEKAAIKPTDIVLEIGPGTGNLTEKLLQTSKKVIAFEIDPRMVAELNKRFQNTPLASKLQIIRGNCLEQDFPYFDKCVANVPYAISSALIFKLLKKPTFKCAVLMFQREFALRVCAQPGSEAYCRLSVNSQLLARCSHLMKISRNSFNPPPKVESSVIRLDPKCPPPAVDFEEWDGLVKMLFNRKNKKASSIFRTKAAVQALHDKYLSYRKMEGGQPVEATAPGSKSATSSSSADATSLMPMQQFRVLLESVIADPMFEKRSRMLDEEALMSMLAHFIKHGIHFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GVY6</accession>
    <name>A0A836GVY6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial import inner membrane translocase subunit TIM50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_01198</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TIM50 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058951.1">
        <property type="nucleotide sequence ID" value="XM_067203260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GVY6"/>
    <dbReference type="SMR" id="A0A836GVY6"/>
    <dbReference type="GeneID" id="92357194"/>
    <dbReference type="KEGG" id="loi:92357194"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000171">
        <property type="entry name" value="Nuclear lim interactor-interacting factor,putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="1" id="KW-0811">Translocation</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FCP1 homology" evidence="3">
        <location>
            <begin position="46"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5466061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="240" mass="27200" checksum="6259F43A17878AC1" modified="2021-09-29" version="1">MNKQRIRGESFKQEYQAAGRHRTNRKRDPSMNKTDPHLVIAPQAEAYQGKLVLVLDLDETLVFARSGPLYARPGIPEFFQMCKDKGIEVVVWTAGLKAYAQAIVSNIDTCNAVSHCIYRHNKWFNGQPGYRKDLNALGRPLDRVLIVENTPDCIRGYQENGILVSDYEGGDGEDNTLYALAELVKVLSESDFTVPQFIANCELLKREPVMTDVGDYINAYTLDTNCFDPEHVRVNRDIQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GW34</accession>
    <name>A0A836GW34_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Flagellar calcium-binding protein EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_05627</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
            <location evidence="1">Flagellum</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000016">
        <property type="protein sequence ID" value="KAG5482371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064377.1">
        <property type="nucleotide sequence ID" value="XM_067207563.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92361497"/>
    <dbReference type="KEGG" id="loi:92361497"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054322">
        <property type="entry name" value="FCABP_EF-hand"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22592">
        <property type="entry name" value="FCaBP_EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0282">Flagellum</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Flagellar calcium-binding protein EF-hand" evidence="8">
        <location>
            <begin position="1374"/>
            <end position="1442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1500"/>
            <end position="1522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1500"/>
            <end position="1512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5482371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1645" mass="182830" checksum="F2BB127FADABBB34" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GX56</accession>
    <name>A0A836GX56_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">30S Ribosomal protein S17-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_01586</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059325.1">
        <property type="nucleotide sequence ID" value="XM_067203634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GX56"/>
    <dbReference type="SMR" id="A0A836GX56"/>
    <dbReference type="GeneID" id="92357568"/>
    <dbReference type="KEGG" id="loi:92357568"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00364">
        <property type="entry name" value="Ribosomal_uS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000261">
        <property type="entry name" value="Putative 30S Ribosomal protein S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_uS17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US17M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5466435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="35964" checksum="95AAF8B6CA348F86" modified="2021-09-29" version="1">MFRHSLLRLPWWNFQTEHRQRCVMMYGGARTKNTHNANHRVYVRKFKRNAFPNRTRHHWAVSMTGVQGQRPRRMPWPYDLTSMIFNQPRQGSDKIGYVVGTSMLKTAVVAANHMVYYPKFNQRVSRTSRFFAHDEDLACVEGDLVHIKQSRKISKYKHYYVFSILEPNIEGRERLKLGLKAVPPPLFGYPVSRRVVKLNLTNTEGTKEKLAAAIQEHVQDAYRFAGPTPDQPRAKLTDSASFDEANKMIAPNASATAELPSGEEPVFLAGGQPVSEEFSEVEEDSRQKKGDDYWMNLQPSDKYDFKNLKKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GXG1</accession>
    <name>A0A836GXG1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">60S acidic ribosomal protein P2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_07290</name>
        <name evidence="9" type="ORF">LSCM4_07291</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">LSCM4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays an important role in the elongation step of protein synthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">P1 and P2 exist as dimers at the large ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000015">
        <property type="protein sequence ID" value="KAG5483075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFHLR010000015">
        <property type="protein sequence ID" value="KAG5483076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064571.1">
        <property type="nucleotide sequence ID" value="XM_067209188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GXG1"/>
    <dbReference type="GeneID" id="92363122"/>
    <dbReference type="KEGG" id="loi:92363122"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002182">
        <property type="term" value="P:cytoplasmic translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05833">
        <property type="entry name" value="Ribosomal_P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001859">
        <property type="entry name" value="Ribosomal_P1/P2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044076">
        <property type="entry name" value="Ribosomal_P2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00456">
        <property type="entry name" value="RIBOSOMALP2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5483075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5483076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="10930" checksum="AE908D386CD19EB8" modified="2021-09-29" version="1">MSTKYLAAYALASLSKPSPSQADVEAICKAVHIAVDKDTLAFVMESIAGRDVATLIAEGAAKMSAMPAASSAGAAAAGGAAPAAAPAAAAAAKKEEPEEEADDDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GZA0</accession>
    <name>A0A836GZA0_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061796.1">
        <property type="nucleotide sequence ID" value="XM_067205859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GZA0"/>
    <dbReference type="GeneID" id="92359793"/>
    <dbReference type="KEGG" id="loi:92359793"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5474690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="226" mass="23976" checksum="F4F0E8DD1DF32ED5" modified="2021-09-29" version="1">MYSKYKSFYENDGSGRDTFVNYAGAYWMNPLPAGTFLKSRPSAAQLSAPTENGTSLVMDDSIPHLGRTLFGKSRYGTNIIAADQAGLLGDAAGSVCGPSASMGSTSGSIHCGVAGAGADGQGFDGEATALEHVSFDVSHPERRLRQPGHATTGLEGTGGGSTFNGVKEPWKAPNAVDNTLLRLAPTYESTCHYHLRTGRFYTEDAAPPHEMTLPDKGVTWGKSRYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H0S0</accession>
    <name>A0A836H0S0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="6">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_00934</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="6"/>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059650.1">
        <property type="nucleotide sequence ID" value="XM_067203000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H0S0"/>
    <dbReference type="SMR" id="A0A836H0S0"/>
    <dbReference type="GeneID" id="92356934"/>
    <dbReference type="KEGG" id="loi:92356934"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06623">
        <property type="entry name" value="PKc_MAPKK_plant_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013:SF9">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="58"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="352"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="358"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="372"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5467848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="384" mass="42576" checksum="F98DF64D167D0F07" modified="2021-09-29" version="1">MPPKLKLLPAKKSTVPPESPEESDELTVGNIRVGPCGVEFTGDGDLQVRRPDLNFENLKRVRQLGQGTQGNVSMYVTPDKSVVAVKKITIPSTLDTRTRQTVAAELRNIFSAQSNEYTVNLYNAFYRHRALRLVMEYMDWGNVDELIAEKVKIPATVCGYIASQMLHALAVLHTKANIVTETNPHKSLRQIHRDIKPANVLLSTNGCVKLADFGIATSAETIGVNSFVGTATYMSPERIQGLRYSTPSDIWSVGVVVAQMLLGRYPFSSVNKGFMALLREINSVEKYPLKDETGCSQEAQDFIDSCLRQNPEDRSSACELLECPWIKYCEENGKAEMVALLASLGDRNRQYHEDDSFQVGSRETSSNAPPDSSDRCAAEKSHKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H0Y6</accession>
    <name>A0A836H0Y6_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_01040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059755.1">
        <property type="nucleotide sequence ID" value="XM_067203105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H0Y6"/>
    <dbReference type="GeneID" id="92357039"/>
    <dbReference type="KEGG" id="loi:92357039"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5467953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="440" mass="49428" checksum="251CEFE146A49FDB" modified="2021-09-29" version="1">MESPAVYRASDARAPLTKANDWIRGMSLQRQEVMREISAVCESGRPLERIAGDDEDGSASLEVPLTSAIADKFQVHMMHRRRLYKQYAMDLSLWADTHSYYQLMMWCHDHHVFVHPTVQMRRQRSAFREHVFEVKDDVDAFTPLLAIPEDLIIGFKDANTESSDPSAGCDDRNNLYDPKREAEFHKLNTGANSDADICQFFFSSLGMIVSDLITAKSSPLTDPRHLFAELLSKVPTLQNAPYFDEEVVFDSSETCLADVLLQMIRNYINGGPLVNKVPLHELRWAVSVSLSHSTPLSIGAVRSIGIVPLVHLFPHGGTATNAYVITRTSRDNCAEKISAFFRDKFGYDFGGQANGRWIYVVPDRPLKAGDEICLQAMAPVCEKDSEAEQMWRLSCGTVPESYIRSAEASARQNDAIRFIVQQGEALWKLSRGRETTSGAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H203</accession>
    <name>A0A836H203_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_07915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000013">
        <property type="protein sequence ID" value="KAG5484349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064842.1">
        <property type="nucleotide sequence ID" value="XM_067209792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H203"/>
    <dbReference type="SMR" id="A0A836H203"/>
    <dbReference type="GeneID" id="92363726"/>
    <dbReference type="KEGG" id="loi:92363726"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="70"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="158"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="214"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="559"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="218"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5484349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1224" mass="131562" checksum="ABC185CE449A0133" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H3B7</accession>
    <name>A0A836H3B7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ankyrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_02790</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060362.1">
        <property type="nucleotide sequence ID" value="XM_067204810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H3B7"/>
    <dbReference type="SMR" id="A0A836H3B7"/>
    <dbReference type="GeneID" id="92358744"/>
    <dbReference type="KEGG" id="loi:92358744"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
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        <location>
            <begin position="40"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="73"/>
            <end position="107"/>
        </location>
    </feature>
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        <location>
            <begin position="450"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="540"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="611"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="450"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="611"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5470096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="675" mass="73452" checksum="75A33EDB8622832B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H5L2</accession>
    <name>A0A836H5L2_9TRYP</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="1" type="ORF">LSCM4_07734</name>
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        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000006">
        <property type="protein sequence ID" value="KAG5487246.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067209613.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="92363547"/>
    <dbReference type="KEGG" id="loi:92363547"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5487246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="451" mass="50415" checksum="FDF477BF46D422BF" modified="2021-09-29" version="1">MSHLQNQVKTCIDDVEDVLASSDTLPNNATSEKISATYQRFLKHVWYELPMSSAGGSALATVSCMPVWELLNQHTSACALSTAPAKAIAVQLLSSMYPKSRDRRCVFQQPSCYGSNSQTAVPLSTQVPFQMLMPKCCAAEQNIEYIKAAQRVLRIAAVGNCTDGKESGAVASAVRTFLNNVLPKCTLISHPRELAKQTRGEFSILWDSPSCDWLSGRIFLLTLWCLLVTTEYLNLPEYRNLSLFLCSSRWSERLIELDERKVSYGELLSPLLDICSLCLSVNPRSVPASVDTVPLLDPRVIPFLMGSWIKEEQREVGACFITEYNARPGTEGKKSLTLRRADYVKEQLIGAIPNEVDFMGTSSSCRDFDQLAYLCRDCLFVPTTKNFTSGISLSRRRDMLFNRKRTRDTSISDGPCFIPVKSTVTNMLEKKDTAALVTLERLCCKWRDDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H5Q3</accession>
    <name>A0A836H5Q3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
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            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5478065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067207404.1"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A836H5Q3"/>
    <dbReference type="GeneID" id="92361338"/>
    <dbReference type="KEGG" id="loi:92361338"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF297">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="126"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5478065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="388" mass="43220" checksum="A30A7A2DEFA56952" modified="2021-09-29" version="1">MPAVEAGKVMNANVRKAAWHGAAELKRHCSHVINTLGPQTPPEAFLYRGNAYYALGQPYFALADYNTAASVLKLSGEHQRRCREALASFPATQTGVYPSTDSHLHIFVKPMLSKSCAIEIVNKYVGRGVRATECMPRNSVVVQPANPWLLYPTKEGLCSYCGVSLPERRFACPNDACHEEYCSRDCRQEAMAHYHAAVCHNKDYQSIELDVFGQMKEAEKGGAVAERNAASAQLLMLRVLSTGMQKHVVPSAMGQVRILSGRLTFSPQMLSSSMLHLYERLARALHITTIVSYEEMVGILARVTANCFHRGSTVELNLPRSMLNHSCAANVAEDGQTGAMITTRDVSRGEELVINYYPHLKDLPYTERTAELERRGFRCMCTKCQRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H610</accession>
    <name>A0A836H610_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_06062</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000011">
        <property type="protein sequence ID" value="KAG5485424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067207987.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="loi:92361921"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ARM-like"/>
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        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042856">
        <property type="entry name" value="RSP14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15599:SF1">
        <property type="entry name" value="RADIAL SPOKE HEAD 14 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15599">
        <property type="entry name" value="RTDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5485424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="402" mass="44365" checksum="61790C1E5D5C5821" modified="2021-09-29" version="1">MWTVLRRRQGLEPNEAPARHHTSYSAHQRCIQLHAVRPYVPDMSPTAFSKAYGDFLYIKMRRWLLDERVDVRLQAADHLVELYKRKREHCVQSLAYDLLPILLSTLEKDESSILRERAGMALELLVRELQTQQLLLGGSFAEDAPSSAPAGKQTAPPPHLAAILSSLRDESDEVVVAGLRVVLACHMWHNSFAVTAALVQEGLIPVLLSLIQSTNTSTQMLACSSMRQLFQVKEAHVELLKLGCVATLTKAIASTEAAALVAEAAEVISLVAEYAQGRRDAVACGTLATLLPHLPSPNLTLRVAVYSAAAQITVLEAAKIQATELGYPDQLLGEIASEDERDVLIHMLRLIYHLAEWPAARVTLRGCLPRIAELLQIAEDDNDVIFVLSQAERILTKKVFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H6A8</accession>
    <name>A0A836H6A8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_06098</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000020">
        <property type="protein sequence ID" value="KAG5480332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063663.1">
        <property type="nucleotide sequence ID" value="XM_067208023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H6A8"/>
    <dbReference type="GeneID" id="92361957"/>
    <dbReference type="KEGG" id="loi:92361957"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5480332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="197" mass="21680" checksum="941595B31A4944DD" modified="2021-09-29" version="1">MRRYAPLCAKAAAGAGGAKCAVGASCTAAASSPAGASSLDSRRNAIFSMRQSPTSLYVDSMHSNTLTDHPLTHRSSRDELAYRKRKLTERGQYEQAARAEEEAAQRDREGKAGAETKEYYWAILCAVLGYLVAHALVFNYYYPNDLRPNYSPDRGYSDDVAARREELEAVDEMVGLSVLESVYSKRKAAAKRRLEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H6B6</accession>
    <name>A0A836H6B6_9TRYP</name>
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        <recommendedName>
            <fullName evidence="2">SURP motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_08066</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000005">
        <property type="protein sequence ID" value="KAG5487621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065909.1">
        <property type="nucleotide sequence ID" value="XM_067209942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H6B6"/>
    <dbReference type="SMR" id="A0A836H6B6"/>
    <dbReference type="GeneID" id="92363876"/>
    <dbReference type="KEGG" id="loi:92363876"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.790">
        <property type="entry name" value="Surp module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051485">
        <property type="entry name" value="SR-CTD_assoc_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000061">
        <property type="entry name" value="Surp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035967">
        <property type="entry name" value="SWAP/Surp_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140">
        <property type="entry name" value="RNA PROCESSING PROTEIN LD23810P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140:SF0">
        <property type="entry name" value="U2 SNRNP-ASSOCIATED SURP MOTIF-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01805">
        <property type="entry name" value="Surp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00648">
        <property type="entry name" value="SWAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109905">
        <property type="entry name" value="Surp module (SWAP domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50128">
        <property type="entry name" value="SURP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SURP motif" evidence="2">
        <location>
            <begin position="229"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="618"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="853"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="400"/>
            <end position="417"/>
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    </feature>
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        <location>
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            <end position="436"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <end position="455"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="624"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
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            <end position="729"/>
        </location>
    </feature>
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        <location>
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            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="853"/>
            <end position="865"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5487621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="988" mass="104362" checksum="B1C8D24F5418FA60" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H7I7</accession>
    <name>A0A836H7I7_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060952.1">
        <property type="nucleotide sequence ID" value="XM_067205400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H7I7"/>
    <dbReference type="GeneID" id="92359334"/>
    <dbReference type="KEGG" id="loi:92359334"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="588"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="558"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5471835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="622" mass="66631" checksum="F4364DE41644F76A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H7L3</accession>
    <name>A0A836H7L3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Phosphoglycan beta 1,3 galactosyltransferase 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LSCM4_03425</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">LSCM4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060982.1">
        <property type="nucleotide sequence ID" value="XM_067205430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H7L3"/>
    <dbReference type="SMR" id="A0A836H7L3"/>
    <dbReference type="GeneID" id="92359364"/>
    <dbReference type="KEGG" id="loi:92359364"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000012">
        <property type="entry name" value="Protease 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032632">
        <property type="entry name" value="Peptidase_M16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054734">
        <property type="entry name" value="PqqF-like_C_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF18">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16187">
        <property type="entry name" value="Peptidase_M16_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22456">
        <property type="entry name" value="PqqF-like_C_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="10">
        <location>
            <begin position="30"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="11">
        <location>
            <begin position="192"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 middle/third" evidence="12">
        <location>
            <begin position="510"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="domain" description="Coenzyme PQQ synthesis protein F-like C-terminal lobe" evidence="13">
        <location>
            <begin position="857"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="445"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1024"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="453"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="465"/>
            <end position="477"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF22456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG5471865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1085" mass="119428" checksum="B44A64BFD70474FA" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H7X3</accession>
    <name>A0A836H7X3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DJ-1/PfpI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_01998</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061072.1">
        <property type="nucleotide sequence ID" value="XM_067204035.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="loi:92357969"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903189">
        <property type="term" value="P:glyoxal metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="GATase1_DJ-1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Protein DJ-1 homolog C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006287">
        <property type="entry name" value="DJ-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
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    </dbReference>
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        <property type="entry name" value="Prot/Nucl_acid_deglycase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01383">
        <property type="entry name" value="not_thiJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094:SF12">
        <property type="entry name" value="PARKINSON DISEASE PROTEIN 7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094">
        <property type="entry name" value="PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="2">
        <location>
            <begin position="2"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5472676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="198" mass="20804" checksum="7C7C5D7D48D25BA1" modified="2021-09-29" version="1">MNVLVVAADDSEDIELVAIIDVLSRGSIKVTLASVMESKDITLAHGTKVACDVLVGEVIGNNYDAVLLPGGMPGAVHLGNSEALKKILHKARESKKLYGAICATPAVALGPMGLLDGVGTVTCYPGFEERLPSSVCYSTRVVVKSGNCLTSRSPGTAIYFGLAAVSLLKSPEVAEDIAKGMLVDKTREMDDVRAIWQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H831</accession>
    <name>A0A836H831_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067205373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H831"/>
    <dbReference type="GeneID" id="92359307"/>
    <dbReference type="KEGG" id="loi:92359307"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="550"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="641"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="728"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="831"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="859"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="877"/>
            <end position="889"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5471808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="889" mass="97564" checksum="2FD3DE4A3D93A481" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H8H2</accession>
    <name>A0A836H8H2_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_07477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000004">
        <property type="protein sequence ID" value="KAG5487799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065996.1">
        <property type="nucleotide sequence ID" value="XM_067209364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H8H2"/>
    <dbReference type="SMR" id="A0A836H8H2"/>
    <dbReference type="GeneID" id="92363298"/>
    <dbReference type="KEGG" id="loi:92363298"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050754">
        <property type="entry name" value="FKBP4/5/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46512">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5487799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="267" mass="27604" checksum="E728A3661D50EA33" modified="2021-09-29" version="1">MSMSLSSSPSSASAPPYSCAKASYCLQQAQAAKAAGNAALQAGNPRGASFEYKKVYLYLAEFLPSDVAQSASPAALGYANCGASDAGGNSGLVHMLQQQQRRKRPTNVEAAAETGSGLSASPSAEAALQKLQAEMTQLYATALNNLALAHMKVGRYHEGVKCATAVLEQPALRAALDAGAQGCTSARFSDTPAGKALLRRASCHVKLSNWALAEEDIRSLTAASGGGTPDGGCDVLDVAVMQLAQAVAQGRQAEAAKEKEMMQRMFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H988</accession>
    <name>A0A836H988_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_02027</name>
    </gene>
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        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
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            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061101.1">
        <property type="nucleotide sequence ID" value="XM_067204064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H988"/>
    <dbReference type="GeneID" id="92357998"/>
    <dbReference type="KEGG" id="loi:92357998"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5472705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="538" mass="58326" checksum="DFA82721825C032B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HDB4</accession>
    <name>A0A836HDB4_9TRYP</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_03816</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067205812.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="92359746"/>
    <dbReference type="KEGG" id="loi:92359746"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5474643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="478" mass="53444" checksum="96B62088032A503A" modified="2021-09-29" version="1">MAYSPACGDLHMEDRITPPYHKQADFAAFLVNEYFTKPSKQIVKARNEDTNGLLPLVLFDSLLPGGDIERTVGHICEETRLIDERHVQHRKPFHVLEKPLIIPALLAALLHRILFEKAGITISSTTFDLWASTALGFPARISRLWLDACSQVEEALEKSSVRQLLSKRSASDTGIHAIKTQADPKGVLLSVWCNACLMLCTLLASPPLSMQTCHEHFGQAIERAVKFRKEIASKTSSALFGKKATGVNLHAAGEPEMCSCLVFHSFFRQLETIFHHAIDSKVKMNASAHILCSVFLACLNAFTYYRYTPAKAESMYKLLDTVAQVTDGRSLAYRFDLKSVEVPQLSRYVQRAAVLSSDEVFGGISYRERKEAWPSPSGTLPPFSEMNYSAISIGDIYPFFRATSTSPEEDKIGERSDSTVLQVHPESEKDESFVETTTIFLDTSEDAKCLPYILSAEEAAAKRQVHERLYGGKRRRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HDV2</accession>
    <name>A0A836HDV2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_05563</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="JAFHLR010000016">
        <property type="protein sequence ID" value="KAG5482310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064316.1">
        <property type="nucleotide sequence ID" value="XM_067207502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HDV2"/>
    <dbReference type="SMR" id="A0A836HDV2"/>
    <dbReference type="GeneID" id="92361436"/>
    <dbReference type="KEGG" id="loi:92361436"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000837">
        <property type="entry name" value="STE family protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF2">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="22"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5482310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="627" mass="66800" checksum="0172892F95C3C77F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HE46</accession>
    <name>A0A836HE46_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062344.1">
        <property type="nucleotide sequence ID" value="XM_067207041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HE46"/>
    <dbReference type="SMR" id="A0A836HE46"/>
    <dbReference type="GeneID" id="92360975"/>
    <dbReference type="KEGG" id="loi:92360975"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5476111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="416" mass="46616" checksum="8EE099686C1ADB89" modified="2021-09-29" version="1">MRQATSPSLCAARVVRQVSSRMGNTLSATKCHPLCARAGSSYARRGAADSKSSGVHLQSSLWISCRDMSASAWRLTPEVRAGDSEENPFAFEFDPMAGVRHDAAVETAKKRVDSIVEELAPPNASSEALEKIRSYLRQHPVDNLIVHAEVQITHMESPDTGAEERVHLSPMGIKDALEQAQLRKMNLVQMGARGDELAYCRIRRERPRVWKLVQPEMDLVSGLTGTPTTNDAVAAQHQEPQKHDTGSGDNQTDRPRQYLGKTKELVDHAFRDAVDDHFIGWRSKKIVQDIRKGHPVKLTIRDFQCPEAAVHKLREMSNAVKTYAEEQRIYHHFTSIIGNEREASLTLSPPMANKSGTISKTVKHPSEKEWAHTLKRMEDACQKAGRSGTYVKSNKLKMRNLGATTYRVDKYGRRMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HF37</accession>
    <name>A0A836HF37_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_07179</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000015">
        <property type="protein sequence ID" value="KAG5482970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064466.1">
        <property type="nucleotide sequence ID" value="XM_067209083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HF37"/>
    <dbReference type="SMR" id="A0A836HF37"/>
    <dbReference type="GeneID" id="92363017"/>
    <dbReference type="KEGG" id="loi:92363017"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015218">
        <property type="term" value="F:pyrimidine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990519">
        <property type="term" value="P:pyrimidine nucleotide import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049562">
        <property type="entry name" value="SLC25A33/36-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829:SF4">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="9"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="107"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="199"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5482970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="35444" checksum="81844E468DEF8176" modified="2021-09-29" version="1">MSSTSSTERDHLVSVFAGGFAGVCSTCVTNPLDTIRVRLSADRSATGKSHKSLLITARELFNRGLVHAFGRGLGANIMASMPSNAVYLPTYRFLKNELTDTRVSEQVRPMICAFGAVTATNLTLSPLFVIRTRVQVDDRLTIHQVFRDVMRRDGVRGLYRGTVTNVAGRFVEEGCFWTVYELLKRLTHEGDFGERGFWWSSAAMVSLTMMAKLVAVGVAYPYNVVMNHLRTVNKATGEHDYVRVMPTVRHIYEADGFLGFYKGLAPQILRSVISKATQIYSFELALFTYAQMHHRRPLPVSAALIIDPIAEPDRSVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HJF8</accession>
    <name>A0A836HJF8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">U2A'/phosphoprotein 32 family A C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_05335</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5477940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062847.1">
        <property type="nucleotide sequence ID" value="XM_067207279.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92361213"/>
    <dbReference type="KEGG" id="loi:92361213"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050836">
        <property type="entry name" value="SDS22/Internalin_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003603">
        <property type="entry name" value="U2A'_phosphoprotein32A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652:SF3">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00446">
        <property type="entry name" value="LRRcap"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="U2A'/phosphoprotein 32 family A C-terminal" evidence="4">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="U2A'/phosphoprotein 32 family A C-terminal" evidence="4">
        <location>
            <begin position="1359"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="domain" description="U2A'/phosphoprotein 32 family A C-terminal" evidence="4">
        <location>
            <begin position="1647"/>
            <end position="1665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="867"/>
            <end position="889"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5477940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1788" mass="192189" checksum="25E45399D2F4C36E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HK90</accession>
    <name>A0A836HK90_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000010">
        <property type="protein sequence ID" value="KAG5485655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065239.1">
        <property type="nucleotide sequence ID" value="XM_067208528.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836HK90"/>
    <dbReference type="GeneID" id="92362462"/>
    <dbReference type="KEGG" id="loi:92362462"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
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                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
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                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
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    <name>A0A836HUE8_9TRYP</name>
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        </recommendedName>
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    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC10 family.</text>
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    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000004">
        <property type="protein sequence ID" value="KAG5487818.1"/>
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    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000233">
        <property type="entry name" value="Anaphase promoting complex, subunit 10-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016901">
        <property type="entry name" value="APC10/Doc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004939">
        <property type="entry name" value="APC_su10/DOC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12936">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12936:SF0">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03256">
        <property type="entry name" value="ANAPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01337">
        <property type="entry name" value="APC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51284">
        <property type="entry name" value="DOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DOC" evidence="7">
        <location>
            <begin position="44"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="176"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="215"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5487818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="354" mass="37378" checksum="196460F9102B01AE" modified="2021-09-29" version="1">MEYDGEDDRESSAEELTQSQGSEQAGSSASALPGSSSLADSTKPSFRILSTPQLAQWVRMHNQMDVGCSGNTVWTVSSAKHGNGVRHLMRHHDLNNFWQSDGVLPHVIRIQLGQLTPVEAMAVYVNSAVDQSYSPRVIRVKAGTHNGDVTEVAKVDIGAGQECGWVLIKLGETAGDDDEGLGGGGGVSSSVGGAAGAMKAQHHRQAVRPHPQDRSASGGSDSGAVSSSSSPIPYNEVAAALGHGNDVTSSASPLSLQPPSSIAGAHAPVSLPIITHSTNSAADRWLWCTLIDICICENQFNGRDCHLRGIRLMGPRYEELERVSNADATDMVACARPLRGDERLDGAADELQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836I091</accession>
    <name>A0A836I091_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleoside diphosphate kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000010">
        <property type="protein sequence ID" value="KAG5485698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065282.1">
        <property type="nucleotide sequence ID" value="XM_067208571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836I091"/>
    <dbReference type="GeneID" id="92362505"/>
    <dbReference type="KEGG" id="loi:92362505"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5485698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="463" mass="48970" checksum="387EF877D7195A98" modified="2021-09-29" version="1">MTAPNEGPEPQWTLLVCMPTCQAAHTVIVRELRDDGVDIVARRFVLTPDQALTIVKQYAHLRRRAAEPHPCISTAAETVAVGPSSQLSVPSELQNPKWPETRSQQPPRRRHHPELQPQGKSPAESGQLLANIMRLVQGHRTQQKAGVSPVPVCGKGSGCACVVVPSSSLSAHPVSRGNKECGSGGSSEPALSSRGISHSRASAAINGTYAAGTVSRSTYESSRLDVVSSPSVAASRKLCTPGMDDHMFPSDPQVLQQVVSLLQGGTVLVLLLRAVNAVERLVRLSGPEDPLEARRVAPESWSARYGDTEARMSVYTPSSLADARVAVDAVFGEDCVDKIGCSNSRLPSQEPLAYGVGGASLAIADPPAAPLRFAQILPTLRAAVPSERRISHYTGVQGPTAVAEGFDDAASAQRAATDDGENAVFAATMGPDPCVYQSTAPQYPQHQERLGEIEDPLGSRVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836I0I5</accession>
    <name>A0A836I0I5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ADP-ribosylation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_07489</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000004">
        <property type="protein sequence ID" value="KAG5487811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066008.1">
        <property type="nucleotide sequence ID" value="XM_067209376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836I0I5"/>
    <dbReference type="SMR" id="A0A836I0I5"/>
    <dbReference type="GeneID" id="92363310"/>
    <dbReference type="KEGG" id="loi:92363310"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001166">
        <property type="entry name" value="ADP-ribosylation factor D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="133"/>
            <end position="136"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5487811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="184" mass="20395" checksum="47CAD681009EEE05" modified="2021-09-29" version="1">MGQLFTSIWGMFKGSKPYKLLILGLNNAGKTSILYHLQLGHSIATQPTLGGNTETLTITHPHTNNTITFTCWDLGGQEQLRASWKLYYDHTDAILFVVDAADAVRFPMAKEVLHQLLHSEPSLQHSTLLVLANKQDVESAAAPAELIEYLELGKLKDRTWTLMGCSASTGESLREAMNWIAENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836K7N2</accession>
    <name>A0A836K7N2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Receptor ligand binding region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_01349</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059094.1">
        <property type="nucleotide sequence ID" value="XM_067203403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836K7N2"/>
    <dbReference type="GeneID" id="92357337"/>
    <dbReference type="KEGG" id="loi:92357337"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032879173" description="Receptor ligand binding region domain-containing protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5466204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="476" mass="51115" checksum="836328E46D16656B" modified="2021-09-29" version="1">MTSKALRLMAVAMGVLLFFASDVQGLNLLFISSGTPSDLLQMAPLVREAYQRNHSATVLVDTLGLSDCKDVFRDSFCTAVTCTQRGCRDKTADLSRAFLTVLRQRSLSPDVILAAAFLYEADRISAQLGVPLVILSGSAGDVPSIRSTFFNVLPFGLGERCPLLEAVVSAIRGFYASAWELIGFGASQNLQMIRHIVTQGIPGIDITGPFCPSVHPVGFLRGDGEVLVKKSFSAVDVYIESCGGRFIYTTMPADNSAHGQQLYSALRAVANATSACVLWYVLSAQQSSLRFPKSSEAQLVKVTDDDSAAPHYLLHRHHPVVVLSNDVKEILYDAVLAESPIVLIGSNSFSCSQLRNAGIAACASSFRTTEVVSAVQSVYNKSSVQEQLRAARRLGFLMGGAQKAVEVAELVAAIGTGSIDFACDRSILLSPYGYDAAIAVPATLFLGALLCVGLHCLHIPLKQHVVWKAHDKERPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836K7V5</accession>
    <name>A0A836K7V5_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_01595</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the unc-50 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059334.1">
        <property type="nucleotide sequence ID" value="XM_067203643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836K7V5"/>
    <dbReference type="GeneID" id="92357577"/>
    <dbReference type="KEGG" id="loi:92357577"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007881">
        <property type="entry name" value="UNC-50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12841">
        <property type="entry name" value="PROTEIN UNC-50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12841:SF6">
        <property type="entry name" value="PROTEIN UNC-50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05216">
        <property type="entry name" value="UNC-50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5466444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="256" mass="28747" checksum="CE49C0A938C92513" modified="2021-09-29" version="1">MLSQCTFVMSRWTSRLPPFVRRAVQVDQMEIDSALSQMYSLCLNPSLVSKMSRARKMTKGHYYRDDPAFLMLQLVFIAVVSVAQWLLLGMRRSLVGTLFAAVAWYILGGLVMACVWRAIAVIYLSPSSTSTQAGVLVDATSALGVDSVVDYLRPDLDWRYAFDVHCNGYFTFFMWTEVIAYFMAPIMKVSWVGNALVAIGATTYLYSVFLGYLEVPSLSYQQRLLYPVLVVGVLFLLFSISDVNVGLALWLPQCAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836K7Y7</accession>
    <name>A0A836K7Y7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PSP1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059439.1">
        <property type="nucleotide sequence ID" value="XM_067203748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836K7Y7"/>
    <dbReference type="GeneID" id="92357682"/>
    <dbReference type="KEGG" id="loi:92357682"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047767">
        <property type="entry name" value="PSP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007557">
        <property type="entry name" value="PSP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830">
        <property type="entry name" value="PROTEIN PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830:SF4">
        <property type="entry name" value="PSP1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04468">
        <property type="entry name" value="PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51411">
        <property type="entry name" value="PSP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP1 C-terminal" evidence="1">
        <location>
            <begin position="149"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5466549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="279" mass="30662" checksum="AA4F6461D1340AE6" modified="2021-09-29" version="1">MSATSSQLSVSCSSRRVKVYRHEPYAASLITPASSAEAVLVCCHQRSPKSPASSYATSSPARSIFEGALPSAPTAACPTYHAAVAFPRQAPMPHPSQTAVWVAFKYGRKPFVTTFQVCMGEMVVVEGDRGVDLGIVDDACTAPFADKALLIIRRATAEDTAMHHSRSMKEQGALLTMRSLAAQVHCPTQVEDTMFQLDGKKITVIISRTSRTFVDFRRLQRALFDVYRCRIWFAYLDEIQETMSTDVTRPLRRGQRRCELSNRGGAKRLMSTASCTAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836K924</accession>
    <name>A0A836K924_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-editing substrate-binding complex 6 protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_00041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058232.1">
        <property type="nucleotide sequence ID" value="XM_067202131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836K924"/>
    <dbReference type="SMR" id="A0A836K924"/>
    <dbReference type="GeneID" id="92356065"/>
    <dbReference type="KEGG" id="loi:92356065"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23735">
        <property type="entry name" value="RESC6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058917">
        <property type="entry name" value="RESC6_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26188">
        <property type="entry name" value="RESC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA-editing substrate-binding complex 6 protein" evidence="1">
        <location>
            <begin position="103"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5464601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="482" mass="52736" checksum="35A95BC3F61F4361" modified="2021-09-29" version="1">MRRLIVCQPTAAFAVARAISTNSFVSSIEQVQQQLQTAQDRRTELLRYGRQLYEMEVLDDLQTAYTPATASKICHVASLLRIDAAKGQPFTAALEAAMTAEGEQSMDVASLARIVHSCLVLRSGHLHEVLFTFIPLLRQKARTMDAVTTAVLINAYGRSEVHHHGLYKDLCDNGAMALKDPRVALAHIANVAYAVSRVKFLHPALMLTLRDHALRKVAEASPIISLTILEAFTELRQIDEELFSAYEQRLLGQLNELQAPLMASLVSCVVRAGRGKAEVMESLGARTVALADTFDAASIAKVTNAFYEADVASEDVLGALAERACKVAADFRADEIATVLNALSAFDLFDAELFPLLASRLVALHRQGGYVDVADAATILSSFAAVQERNDELIFVCTQLFAAYPGVAMDPVARVNALWACASLNVHNEAQTRMLEEVRTTPSLVMWEARADMLPKAKSTLEERRQFLTKVYGITIPSSGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836K939</accession>
    <name>A0A836K939_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Intraflagellar transport protein 122 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_00101</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
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    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG5464661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_067202191.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="loi:92356125"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:intraciliary transport particle A"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:non-motile cilium"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:intraciliary retrograde transport"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061512">
        <property type="term" value="P:protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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    </dbReference>
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        <property type="entry name" value="WD40_repeat_dom_sf"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12764:SF4">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 122 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12764">
        <property type="entry name" value="WD REPEAT DOMAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23381">
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Beta-prop_IFT122_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="8"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="IFT122 first beta-propeller" evidence="10">
        <location>
            <begin position="21"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="55"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="IFT122 first beta-propeller" evidence="10">
        <location>
            <begin position="192"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="IFT122 second beta-propeller" evidence="9">
        <location>
            <begin position="299"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Intraflagellar transport protein 122 homolog TPR" evidence="11">
        <location>
            <begin position="677"/>
            <end position="982"/>
        </location>
    </feature>
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        <location>
            <begin position="1105"/>
            <end position="1129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00019442"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF23377"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF23381"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF25295"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5464661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1296" mass="145509" checksum="505B2B04D8E08AEF" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836K944</accession>
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        <recommendedName>
            <fullName evidence="2">Inositol polyphosphate-related phosphatase domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="3" type="ORF">LSCM4_00116</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058307.1">
        <property type="nucleotide sequence ID" value="XM_067202206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836K944"/>
    <dbReference type="GeneID" id="92356140"/>
    <dbReference type="KEGG" id="loi:92356140"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
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        <property type="entry name" value="IP5"/>
    </dbReference>
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        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LD06095P"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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        <location>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="610"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5464676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="930" mass="100691" checksum="0FC68B7F5297D085" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KA55</accession>
    <name>A0A836KA55_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5468934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059911.1">
        <property type="nucleotide sequence ID" value="XM_067204359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KA55"/>
    <dbReference type="GeneID" id="92358293"/>
    <dbReference type="KEGG" id="loi:92358293"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5468934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="78" mass="8830" checksum="75E220275AA66F01" modified="2021-09-29" version="1">MWQRHFVLQGNPYRAFSLCWRRYDRLALAELRVGYGAAADAFCNNCNDAYAREAPSSSESSPLLAPAMTDTRRDLTVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KAB4</accession>
    <name>A0A836KAB4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methyltransferase</fullName>
            <ecNumber evidence="6">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_00253</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4 5 6">Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058443.1">
        <property type="nucleotide sequence ID" value="XM_067202342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KAB4"/>
    <dbReference type="SMR" id="A0A836KAB4"/>
    <dbReference type="GeneID" id="92356276"/>
    <dbReference type="KEGG" id="loi:92356276"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003838">
        <property type="term" value="F:sterol 24-C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000334">
        <property type="entry name" value="Methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050447">
        <property type="entry name" value="Erg6_SMT_methyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030384">
        <property type="entry name" value="MeTrfase_SMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013705">
        <property type="entry name" value="Sterol_MeTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068:SF1">
        <property type="entry name" value="HYPOTHETICAL LOC100005854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068">
        <property type="entry name" value="ZGC:194242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08498">
        <property type="entry name" value="Sterol_MT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51685">
        <property type="entry name" value="SAM_MT_ERG6_SMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase Erg6/SMT-type" evidence="7">
        <location>
            <begin position="56"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5464812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="353" mass="40246" checksum="90CA6C816EA6FBA7" modified="2021-09-29" version="1">MSAGAREIAPTNLFRRRNKGETNEDVSAAADRFRERFEKASLEERKAATTTMVNEYYDLVTDFYEYGWGQNFHFAPRYAGETFYESIARHEYFLAARGGFKEGDQIVDIGCGVGGPARNIVRLTRCNVTGVNNNDYQISRARRHDARAGMSSKIDYVKTDFCNMCLDDNTFDGAYAIEATCHAKDKVKCYSEVFRVIKPGSCFVLYEWCMTDKYNPDDEYHRKIKHRIELGDGLPEMETYKQVIKYVKQAGFVVEESVDVIEQFESSSIKSIPWYQPLLGSYSSLQGLRSTPMGRIFTNVMCRVLEFLHLAPRGTHKTTEILEEAAKGLVIGGQLGIFTPSFYIRARKPLKQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KCV7</accession>
    <name>A0A836KCV7_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_00801</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059524.1">
        <property type="nucleotide sequence ID" value="XM_067202874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KCV7"/>
    <dbReference type="GeneID" id="92356808"/>
    <dbReference type="KEGG" id="loi:92356808"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5467722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="555" mass="59897" checksum="7B83B4EB76EFF0AD" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KD56</accession>
    <name>A0A836KD56_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_01626</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059365.1">
        <property type="nucleotide sequence ID" value="XM_067203674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KD56"/>
    <dbReference type="GeneID" id="92357608"/>
    <dbReference type="KEGG" id="loi:92357608"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043812">
        <property type="term" value="F:phosphatidylinositol-4-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF2">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3-PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="931"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="959"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="domain" description="SAC" evidence="3">
        <location>
            <begin position="463"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="734"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5466475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1004" mass="110135" checksum="1B2E7158DC9A3C68" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KDM9</accession>
    <name>A0A836KDM9_9TRYP</name>
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        <recommendedName>
            <fullName evidence="8">Leucine-rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_02689</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060267.1">
        <property type="nucleotide sequence ID" value="XM_067204715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KDM9"/>
    <dbReference type="GeneID" id="92358649"/>
    <dbReference type="KEGG" id="loi:92358649"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22710">
        <property type="entry name" value="X-RAY RADIATION RESISTANCE ASSOCIATED PROTEIN 1 XRRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22710:SF2">
        <property type="entry name" value="X-RAY RADIATION RESISTANCE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="582"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="671"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="610"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5470001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="756" mass="81695" checksum="5D4AF674FAEE5CD9" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KDY4</accession>
    <name>A0A836KDY4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_02082</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061155.1">
        <property type="nucleotide sequence ID" value="XM_067204118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KDY4"/>
    <dbReference type="GeneID" id="92358052"/>
    <dbReference type="KEGG" id="loi:92358052"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050369">
        <property type="entry name" value="RBOH/FRE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972:SF69">
        <property type="entry name" value="FERRIC REDUCTION OXIDASE 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972">
        <property type="entry name" value="NADPH OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="419"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="455"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="500"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="531"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="8">
        <location>
            <begin position="575"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="896"/>
            <end position="961"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5472759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1080" mass="118711" checksum="605007620825A384" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KGS4</accession>
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    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_00459</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465008.1"/>
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</entry>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
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</entry>
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            <taxon>Leishmania</taxon>
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    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG5476149.1"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF23098"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="700" mass="76391" checksum="521C48C47B1178B4" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KHW1</accession>
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        <recommendedName>
            <fullName evidence="3">CS domain-containing protein</fullName>
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    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061907.1">
        <property type="nucleotide sequence ID" value="XM_067205970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KHW1"/>
    <dbReference type="SMR" id="A0A836KHW1"/>
    <dbReference type="GeneID" id="92359904"/>
    <dbReference type="KEGG" id="loi:92359904"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06467">
        <property type="entry name" value="p23_NUDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="3">
        <location>
            <begin position="7"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="130"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="503"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="192"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="503"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="514"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5474801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="651" mass="71762" checksum="DA6D47EE44B22F8A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KKM4</accession>
    <name>A0A836KKM4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA repair protein RAD51 homolog 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_02576</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060155.1">
        <property type="nucleotide sequence ID" value="XM_067204603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KKM4"/>
    <dbReference type="SMR" id="A0A836KKM4"/>
    <dbReference type="GeneID" id="92358537"/>
    <dbReference type="KEGG" id="loi:92358537"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033063">
        <property type="term" value="C:Rad51B-Rad51C-Rad51D-XRCC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033065">
        <property type="term" value="C:Rad51C-XRCC3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000707">
        <property type="term" value="P:meiotic DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052093">
        <property type="entry name" value="HR_Repair_Mediator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46239:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46239">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 3 RAD51C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="9">
        <location>
            <begin position="218"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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            <end position="180"/>
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    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
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            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
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            <end position="426"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="148"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="415"/>
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        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5469178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="690" mass="72956" checksum="9B2AB83D2F089810" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KL87</accession>
    <name>A0A836KL87_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_03901</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061831.1">
        <property type="nucleotide sequence ID" value="XM_067205894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KL87"/>
    <dbReference type="GeneID" id="92359828"/>
    <dbReference type="KEGG" id="loi:92359828"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006696">
        <property type="entry name" value="DUF423"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43461">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43461:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04241">
        <property type="entry name" value="DUF423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5474725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="131" mass="14240" checksum="F0CCC7BFB0B9994C" modified="2021-09-29" version="1">MFLQSAHVPTVLVGCVGLSSFAMDFLGTHLKTKLNMRQRRSWLTANQYHMVHTVALAAVAWMMALAKESSEASSRLAKGFYLILAGALGFSGSIYSLCLRICPKFMGPLTPTSGLVLVLGWTNVALAGLYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KL96</accession>
    <name>A0A836KL96_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="5">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_05756</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <reaction evidence="1 5">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
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        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="loi:92361621"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Peptidase_C19"/>
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        <property type="entry name" value="Peptidase_C19_UCH"/>
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        <property type="entry name" value="USP"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3 5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <feature type="compositionally biased region" description="Low complexity" evidence="6">
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            <end position="158"/>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="RuleBase" id="RU366025"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5479749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="718" mass="77819" checksum="81214A49E7B16350" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">LSCM4_05832</name>
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        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063535.1">
        <property type="nucleotide sequence ID" value="XM_067207762.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92361696"/>
    <dbReference type="KEGG" id="loi:92361696"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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        <location>
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            <end position="255"/>
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        <location>
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        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5479824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="2055" mass="217149" checksum="0F5C00204BCD21ED" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836KLJ2_9TRYP</name>
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        <recommendedName>
            <fullName evidence="4">tRNA/rRNA methyltransferase SpoU type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
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        </lineage>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG5470153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067204867.1"/>
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    <dbReference type="KEGG" id="loi:92358801"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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    <dbReference type="InterPro" id="IPR051259">
        <property type="entry name" value="rRNA_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43191">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43191:SF2">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5470153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="663" mass="71684" checksum="A67A930A4B1FBB87" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KP58</accession>
    <name>A0A836KP58_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="8">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_06103</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">LSCM4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ATP = O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23052"/>
            <dbReference type="Rhea" id="RHEA-COMP:13689"/>
            <dbReference type="Rhea" id="RHEA-COMP:13690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="8"/>
    <dbReference type="EMBL" id="JAFHLR010000020">
        <property type="protein sequence ID" value="KAG5480337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063668.1">
        <property type="nucleotide sequence ID" value="XM_067208028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KP58"/>
    <dbReference type="SMR" id="A0A836KP58"/>
    <dbReference type="GeneID" id="92361962"/>
    <dbReference type="KEGG" id="loi:92361962"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16929">
        <property type="entry name" value="HATPase_PDK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF3">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="9">
        <location>
            <begin position="298"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5480337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="451" mass="51027" checksum="4CC21C1D3749437D" modified="2021-09-29" version="1">MRRLFLTTKLPVFKVGARSTSTKSPDRERLERLVEEVNAIKSKLKVLEESKAANGLVDLYASRKMKTLDIKRILGIFNDRAYNAPIFCHKTLPIVLAHFITGLDRLPSGLNAMPSILSVRATLLHSFKKLINCKIPVTDDQVQHFRRVVEDIDESHAERELLQTMAFGILELKEYVSCHRRALVELKKTSKRWASIPMTEEDVLTYAEIQDIQAPLDSVNRCMITYNFISRMFLNHDPESMMGDKPSRVGMVDLEMNLEHVVRNAVDEAKQICTDHYGDCPDTEFELTSDSTAFRFPYMSTTIRYIILELMKNAFRATVESHMKRNDLGIVTCADMPPIRVLINLQEGTEHACICISDEGMGMTDEALAMAMAYSYTSVSKPALQLSESGEKCASTAPSPLAGYGYGLPMSRVYAQLLGGDLFLQTMEGYGTRAYYYIKISETEHFHDDKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KPN0</accession>
    <name>A0A836KPN0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear cap binding complex subunit CBP30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000019">
        <property type="protein sequence ID" value="KAG5480862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063863.1">
        <property type="nucleotide sequence ID" value="XM_067208351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KPN0"/>
    <dbReference type="GeneID" id="92362285"/>
    <dbReference type="KEGG" id="loi:92362285"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005846">
        <property type="term" value="C:nuclear cap binding complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043967">
        <property type="entry name" value="CBP30"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19041">
        <property type="entry name" value="CBP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5480862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="37612" checksum="270E81F9B75301A0" modified="2021-09-29" version="1">MSSPSGQHSRGGGNRGSGFVHLNTPATIQYTAGKTLSLSALRELKSRVECTALPESLSVWRDAFQRYVKEEGYSSFAVDIEDERSGNGPILPPLVQQRVGPVRRRAREVVSATDAFFCTSSPLPSLRIPATAAQTGADGLPLTVGTDSTAGPAACANSTSTRSASSITAAPASGVAHGLASSTMKQQEGIAIVSHHRILGRQKFVYPDHDGVLSAGVVPQIVVTAEEKAEEEAARAFYISPLAMSEEELAAFEELQALWKSRARSHSFLGAQHRRAAKGSADPSSSTDMLDAGDAGMPKMPRREGVTGGASLASRGSNKMGAHAYDEAETTVEEETALDKELAEALRMADDLLRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KQJ8</accession>
    <name>A0A836KQJ8_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_06944</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000017">
        <property type="protein sequence ID" value="KAG5481867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064227.1">
        <property type="nucleotide sequence ID" value="XM_067208853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KQJ8"/>
    <dbReference type="SMR" id="A0A836KQJ8"/>
    <dbReference type="GeneID" id="92362787"/>
    <dbReference type="KEGG" id="loi:92362787"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5481867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="83" mass="8944" checksum="C9EBB458DB7A0D22" modified="2021-09-29" version="1">MSGARVAAFSKYFAVGGLCAVLVCARHSAFLIADDSLQFQRVCANVARYATEATALEEYLESKGLSIAKIQSRTNLSWPATVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KQP6</accession>
    <name>A0A836KQP6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Amastin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_03858</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12318">
        <property type="entry name" value="TESTOSTERONE-REGULATED PROTEIN RP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032778407" description="Nudix hydrolase domain-containing protein" evidence="7">
        <location>
            <begin position="29"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5480350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="413" mass="45030" checksum="EF957B3399734EE3" modified="2021-09-29" version="1">MSANLKAAVPRLAGTILLLARCPQRAMSKQPPTTGDTASRGNDIHVLMMKRHGRARFMPSVYVFPGGGVEGTDYATAKRYLAEHYNLQLRDAEDNNKASQRFLESDAQSTAEEAEVEAWACRVAALRELTEEAACVFRRDGCICSEAQWMKWQMSRKDVGAAGGTPTATTSFLPATPPPVYDLSAVSSLRPVARWVSPRQLKYRYDTYFYAALVNAALVSAEAHEAEPASCSLRAFNDGAASACEGIRRISPQELPLLQQASEVSELLWANPLDALRRHEDPSDTFSLAPPTYLMLHALSLQPSFASIAAAWAANPPSSPDAEAQPLGKLPYSSVLPCVEPLSTMAEDRQCTIDFVLPSRYFHEAGWSVADGEYIFPGDNVAGRRHLIRMFVGKAGATKSDGATTGNAQRFFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KT76</accession>
    <name>A0A836KT76_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LSCM4_06957</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the steroid 5-alpha reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000017">
        <property type="protein sequence ID" value="KAG5481880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064240.1">
        <property type="nucleotide sequence ID" value="XM_067208866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KT76"/>
    <dbReference type="GeneID" id="92362800"/>
    <dbReference type="KEGG" id="loi:92362800"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003865">
        <property type="term" value="F:3-oxo-5-alpha-steroid 4-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039357">
        <property type="entry name" value="SRD5A/TECR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556:SF57">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0221">Differentiation</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0492">Microsome</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="15">
        <location>
            <begin position="401"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="15">
        <location>
            <begin position="494"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG5481880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="539" mass="58447" checksum="0007A2F7B1311174" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KT84</accession>
    <name>A0A836KT84_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_07352</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000008">
        <property type="protein sequence ID" value="KAG5486424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065490.1">
        <property type="nucleotide sequence ID" value="XM_067209247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KT84"/>
    <dbReference type="GeneID" id="92363181"/>
    <dbReference type="KEGG" id="loi:92363181"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033000075" evidence="3">
        <location>
            <begin position="29"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="279"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="339"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="524"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="629"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="656"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="770"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="796"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="825"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="583"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="731"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5486424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="942" mass="102402" checksum="9A3AAB7CF7C980AE" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KT86</accession>
    <name>A0A836KT86_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_06804</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000009">
        <property type="protein sequence ID" value="KAG5486096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065427.1">
        <property type="nucleotide sequence ID" value="XM_067208716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KT86"/>
    <dbReference type="SMR" id="A0A836KT86"/>
    <dbReference type="GeneID" id="92362650"/>
    <dbReference type="KEGG" id="loi:92362650"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="74"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="353"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="292"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="356"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5486096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="458" mass="51732" checksum="B5054C13F5498F42" modified="2021-09-29" version="1">MLLFRHSAEHTVDDQEHDELVDSITEHNELNTTAAGENEAQTDAADSLVLREASQSSEPCEGTENALHFARERTVPPLDEDEMTDHQHRNHGDDDEADVTAAAPAASAPVPFNDVSALPTPRINHAAPRSASNGNPVQRHGNYAYTPLGTARSPRSTSGISRGRSYSLSGLSAAELAEARGKHYRRCSSVVQSARTLSARRASSLNGVVGVIDDLYTSPGRRGSAMTEGERVAVHRMIENEFRRQEVTERLMQFTLARETAVVEEELAREKASYVRRVHLDEELHARLQKAHRDRQERMAAAAQRRQELQEERQRALFDSWRERSTRYHFRDPYTMLDVQRRYSIEARNYAAVAPQRRDSSPFRIKSKENSQVSRRASEGATNSNTDHPCTSPPVTGRRSITPRVDTSRPRRCLPLDAWKPPQQRKDSRQRCYSAPRQGLSRQSWRAATVVDHPRGWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KT95</accession>
    <name>A0A836KT95_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_06834</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000009">
        <property type="protein sequence ID" value="KAG5486126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065457.1">
        <property type="nucleotide sequence ID" value="XM_067208746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KT95"/>
    <dbReference type="GeneID" id="92362680"/>
    <dbReference type="KEGG" id="loi:92362680"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF151">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="47"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="458"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5486126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="573" mass="63633" checksum="F05F78B6F6B92F21" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KTQ5</accession>
    <name>A0A836KTQ5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PUA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_05950</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000011">
        <property type="protein sequence ID" value="KAG5485317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065054.1">
        <property type="nucleotide sequence ID" value="XM_067207880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KTQ5"/>
    <dbReference type="SMR" id="A0A836KTQ5"/>
    <dbReference type="GeneID" id="92361814"/>
    <dbReference type="KEGG" id="loi:92361814"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11609">
        <property type="entry name" value="MCT1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21155">
        <property type="entry name" value="PUA_MCTS-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016437">
        <property type="entry name" value="MCT-1/Tma20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041366">
        <property type="entry name" value="Pre-PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048248">
        <property type="entry name" value="PUA_eIF2d-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22798:SF0">
        <property type="entry name" value="MALIGNANT T-CELL-AMPLIFIED SEQUENCE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22798">
        <property type="entry name" value="MCT-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17832">
        <property type="entry name" value="Pre-PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26292">
        <property type="entry name" value="PUA_elF2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005067">
        <property type="entry name" value="Tma_RNA-bind_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PUA" evidence="4">
        <location>
            <begin position="101"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR005067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5485317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="196" mass="21605" checksum="75B6C6D16E527E60" modified="2021-09-29" version="1">MTSSADLFKKFTLENVAQIASSSHKEQKEVREELAEQYPALSEYWDEILPKKSDIYIIRCQGQVHCVTLVSSQPEVLFFNHHGGPYLPHLKLLHKYPFILKSHQVDIGGCRYIVSGANIMCQGLTSAGGVVADGTEEGEVVAVYVEGKEHAVAVGTMLMSSEEIKDKNKGPCIENIHHLGDGLWMNPILSASHTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KTQ7</accession>
    <name>A0A836KTQ7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA polymerase</fullName>
            <ecNumber evidence="14">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">LSCM4_05695</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Polymerase alpha in a complex with DNA primase is a replicative polymerase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="14"/>
    <dbReference type="EMBL" id="JAFHLR010000016">
        <property type="protein sequence ID" value="KAG5482435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064441.1">
        <property type="nucleotide sequence ID" value="XM_067207627.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836KTQ7"/>
    <dbReference type="GeneID" id="92361561"/>
    <dbReference type="KEGG" id="loi:92361561"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KTR2</accession>
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            <fullName evidence="5">Serine/threonine-protein phosphatase 4 regulatory subunit 4</fullName>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <feature type="repeat" description="HEAT" evidence="1">
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        <location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5477908.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KUB0</accession>
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        <recommendedName>
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        <name evidence="4" type="ORF">LSCM4_07279</name>
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        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="protein sequence ID" value="KAG5483065.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067209178.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SKI-interacting protein SKIP SNW" evidence="3">
        <location>
            <begin position="266"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="179"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="505"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="314"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="104"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="219"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="516"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="526"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5483065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="554" mass="58335" checksum="EFACEAC5E6370BEF" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KUD7</accession>
    <name>A0A836KUD7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">tRNA carboxymethyluridine synthase</fullName>
            <ecNumber evidence="15">2.3.1.311</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">LSCM4_04786</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>uridine(34) in tRNA + acetyl-CoA + S-adenosyl-L-methionine + H2O = 5-(carboxymethyl)uridine(34) in tRNA + 5'-deoxyadenosine + L-methionine + CoA + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:61020"/>
            <dbReference type="Rhea" id="RHEA-COMP:10407"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74882"/>
            <dbReference type="EC" id="2.3.1.311"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:61021"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">tRNA modification.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ELP3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.311" evidence="15"/>
    <dbReference type="EMBL" id="JAFHLR010000023">
        <property type="protein sequence ID" value="KAG5478553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063214.1">
        <property type="nucleotide sequence ID" value="XM_067206767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KUD7"/>
    <dbReference type="SMR" id="A0A836KUD7"/>
    <dbReference type="GeneID" id="92360701"/>
    <dbReference type="KEGG" id="loi:92360701"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106261">
        <property type="term" value="F:tRNA uridine(34) acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000095">
        <property type="entry name" value="Histone acetyltransferase, ELP3 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039661">
        <property type="entry name" value="ELP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034687">
        <property type="entry name" value="ELP3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032432">
        <property type="entry name" value="Radical_SAM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01211">
        <property type="entry name" value="ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135:SF3">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16199">
        <property type="entry name" value="Radical_SAM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01086">
        <property type="entry name" value="elongater_protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00344">
        <property type="entry name" value="ELP3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="18">
        <location>
            <begin position="499"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAG5478553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="710" mass="79848" checksum="3E3FA065F4BBCAF8" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KUL9</accession>
    <name>A0A836KUL9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nitroreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_08071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000005">
        <property type="protein sequence ID" value="KAG5487626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065914.1">
        <property type="nucleotide sequence ID" value="XM_067209947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KUL9"/>
    <dbReference type="SMR" id="A0A836KUL9"/>
    <dbReference type="GeneID" id="92363881"/>
    <dbReference type="KEGG" id="loi:92363881"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="entry name" value="NADH Oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050461">
        <property type="entry name" value="Nitroreductase_HadB/RutE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43543">
        <property type="entry name" value="MALONIC SEMIALDEHYDE REDUCTASE RUTE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43543:SF1">
        <property type="entry name" value="MALONIC SEMIALDEHYDE REDUCTASE RUTE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="FMN-dependent nitroreductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="92"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5487626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="322" mass="34398" checksum="50924540D0FC2E5D" modified="2021-09-29" version="1">MLGHSCRRLIAAAGAGAGATSPRVSDAASACGNEVREGRTNGNGGCLARLRNLMVWNRTNAAAAALSSPVSCGTTPAPISSGAALDAVEAAVRERWTCRQFDTAKPIDLGTLKRILAATTRAPTGFNLQGWHAVVVTNMEVREQLFQAALGQPQVLQAPVTVVFVGDVEPERNAPQALEMGLETGYYGPLYGATYLRNVYYFMHGGPMQSMAAVKSIVSSWYSRAAGTPLVSVPVSRAGYAWKQTMIPASAFVQLCTAAGWDTCMMEGIDEDAVKRAVGVPVERYTVPVIVSVGYATAAEAEKRRVRSPRFATLHTVRWNKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KW72</accession>
    <name>A0A836KW72_9TRYP</name>
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        <recommendedName>
            <fullName evidence="5">ZZ-type domain-containing protein</fullName>
        </recommendedName>
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    <gene>
        <name evidence="6" type="ORF">LSCM4_06104</name>
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    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
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        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG5480338.1"/>
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        <property type="nucleotide sequence ID" value="XM_067208029.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="92361963"/>
    <dbReference type="KEGG" id="loi:92361963"/>
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        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="5">
        <location>
            <begin position="684"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="735"/>
            <end position="759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5480338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="799" mass="89885" checksum="A20AFC60D8491014" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KW89</accession>
    <name>A0A836KW89_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000020">
        <property type="protein sequence ID" value="KAG5480383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063714.1">
        <property type="nucleotide sequence ID" value="XM_067208074.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92362008"/>
    <dbReference type="KEGG" id="loi:92362008"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="646"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="854"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1069"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1130"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1183"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1254"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1343"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1461"/>
            <end position="1484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="866"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="891"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="911"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1261"/>
            <end position="1273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5480383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1617" mass="170076" checksum="B25D08A333EB0B8B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KXD4</accession>
    <name>A0A836KXD4_9TRYP</name>
    <protein>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="1" type="ORF">LSCM4_07338</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000008">
        <property type="protein sequence ID" value="KAG5486410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065476.1">
        <property type="nucleotide sequence ID" value="XM_067209233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KXD4"/>
    <dbReference type="SMR" id="A0A836KXD4"/>
    <dbReference type="GeneID" id="92363167"/>
    <dbReference type="KEGG" id="loi:92363167"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5486410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="67" mass="7707" checksum="7EC8F5E543F16939" modified="2021-09-29" version="1">MTSIKDLNDRLTKQPYVSGYMPSVDDEVLFSEIFGDNVKVMQWAARMATYYPSERAKIQLSPAEEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KXR9</accession>
    <name>A0A836KXR9_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000017">
        <property type="protein sequence ID" value="KAG5481853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064213.1">
        <property type="nucleotide sequence ID" value="XM_067208839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KXR9"/>
    <dbReference type="GeneID" id="92362773"/>
    <dbReference type="KEGG" id="loi:92362773"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5481853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="577" mass="63760" checksum="F9AF077FB8C97C69" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KZ48</accession>
    <name>A0A836KZ48_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aromatic amino acid beta-eliminating lyase/threonine aldolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_08347</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000001">
        <property type="protein sequence ID" value="KAG5488270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066317.1">
        <property type="nucleotide sequence ID" value="XM_067210216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KZ48"/>
    <dbReference type="GeneID" id="92364150"/>
    <dbReference type="KEGG" id="loi:92364150"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
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            <begin position="35"/>
            <end position="310"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5488270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="365" mass="40043" checksum="4BC6B0C16AEF2CE7" modified="2021-09-29" version="1">MPRTTAPSTTPAAAAMAKPQRYSFSNDYSVGMHAAILERIVCDNMTQHVGYGLDSHCAEAARVIRQRIEQPTAEVHFIPGGTQTNLIACSLALRPWEAVIATHLGHVSTHETGAIEATGHKVFTVPCPDGKLRVADIENALHENCTEHMVVPKLVYISNTTEVGTQYTKQELEDISALCKAHNLYLFLDGARLASALSSPVNDLTLADIARLTDMFYIGATKAGGLFGEALVLLHDALKPNARHLIKQRGALMAKGWMLGIQFEVLMKNNLFTELGAHANKTAAILKAGLEACGIQLAWPSESNQQFPIMTDAMIAELRKYFDFETFEPLKNGTSIVRLCTSWATEEEECHRFVEILKRVAANTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FTQ7</accession>
    <name>A0A836FTQ7_9TRYP</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02504</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5469107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="93" mass="10512" checksum="FE900DF76C2AC2F6" modified="2021-09-29" version="1">MPRVSALLCSKVAPQPFHTLVHELLEVQHTSGRALMSAMGPKCYTTRGTRLIGSANFLCFTTYCLMINWIYEGYVDLWYGVYGLEEDADDDND</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G3G8</accession>
    <name>A0A836G3G8_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    <gene>
        <name evidence="2" type="ORF">LSCM4_00059</name>
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    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Euglenozoa</taxon>
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            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067202149.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="92356083"/>
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    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
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    </dbReference>
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        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032719643" evidence="1">
        <location>
            <begin position="22"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5464619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="214" mass="23397" checksum="15C3495DB46EB65A" modified="2021-09-29" version="1">MSATHALRDKWFVSFLPLLTADMVNTDYKGNWQLAAQERTQKLDWITSVEELWSTVNSLPKVHQLGMGSTLIFARNNKEPPSYEAYPNGSRIMINLLKPPTTDAGLELVLAVVMGETIAEKASDGKPVCDVLRIAARPSREHSEQIRVEVWLSDSTRSHAVAEFLAEAMKEKGLAANSYNIAESSFDAAAPSKDKKALGASTALSPSSPPIVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G3T1</accession>
    <name>A0A836G3T1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminotransferase class V domain-containing protein</fullName>
        </recommendedName>
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    <gene>
        <name evidence="3" type="ORF">LSCM4_03755</name>
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    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067205751.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="92359685"/>
    <dbReference type="KEGG" id="loi:92359685"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
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    </dbReference>
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        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
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        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
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    <dbReference type="PANTHER" id="PTHR43092:SF2">
        <property type="entry name" value="HERCYNYLCYSTEINE SULFOXIDE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43092">
        <property type="entry name" value="L-CYSTEINE DESULFHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PLP-dependent transferases"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5474582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="586" mass="65817" checksum="B3564A3C2DC9F119" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G453</accession>
    <name>A0A836G453_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_00460</name>
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    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </source>
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        <source>
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    </evidence>
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        <source>
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    <sequence length="433" mass="49514" checksum="1C2AF9670E17CD4E" modified="2021-09-29" version="1">MDSTSTTSTEANAPLSVATADASTSDPMNIRQPCQHSGKRPPMANSGASQKQRPPQPAYAGKSSGRTSELGISDFESPYGAVAVSRDGQSRRADSALDDAQNGDFSSPAAPLDRPHDEEFDAVEQRARMALESIATRAEEVEPNMGEHIEVLQSYRTACQARAMYREAYLVQQVLRNLRLEEESRHVRGITEQQMEERRMLEEAHRQEFREFHHSWNARIDAFEEEQLEAELALLERQNEELLRFQKEMRDFQPRLIKFSRSLLESRLRQQTLAKQRDYVGAQAQKVHAEAIELADGERFEAARATMFERREYAMHHRHQQELYALRMKVESRRLYLERYRKQELDVLLQRYINIRRSMESQQNIVRNKTGTLLLKHACNMKTDNSGTAVLVESAGSGAFGTVVQRRQAHELHAPLSQPERASAEVHDGSRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467849.1"/>
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            <dbReference type="EMBL" id="KAG5467849.1"/>
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    </evidence>
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        </source>
    </evidence>
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</entry>
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                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="422" mass="43909" checksum="D21B03810D66C58A" modified="2021-09-29" version="1">MGQSTSSLRLSPSNDEGVGAAAKHNESRYAGSTEPPVMELQNTPCAPTFPPAASAAEFAEVNDPKGSVNAPGNARSTAAGIPILCLDASAQCSDQLFKSLELPPARRARALQEASKHASGILLHAPITTTVRDLKQFLLAQTALSVPANTVSSRALALRMFSIRDPLLSSVDGAAADGASSCGSAEASSNLLLALPESMELSTLTMDSQLFFFPAMESSRTGGDPLARDHPCVSAMDSNLAALRQEDSGAEAAVVACSLADTDDIPAAGRALVLLYSREASFGFDGDDMLLLTCCVSICACIAAGICCCASASKNRQTLNNANTKPNNANGGNRVPTYNTNGGAAAYYGHPPQQEYYSSGAPGYGTRPNTYTNSYSNPLYQPLPQPNYYGGTSQYQPYNPQVNGIPMQPVTCAPSAPAPIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836G8L5_9TRYP</name>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5470176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="555" mass="58043" checksum="DD035730F1018FF9" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836G8N6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">V-SNARE coiled-coil homology domain-containing protein</fullName>
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    <organism evidence="4 5">
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    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060472.1">
        <property type="nucleotide sequence ID" value="XM_067204920.1"/>
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    <dbReference type="GeneID" id="92358854"/>
    <dbReference type="KEGG" id="loi:92358854"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15843">
        <property type="entry name" value="R-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057236">
        <property type="entry name" value="DUF7914"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25501">
        <property type="entry name" value="DUF7914"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="3">
        <location>
            <begin position="1230"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1158"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1158"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1195"/>
            <end position="1218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5470206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1292" mass="139596" checksum="C28E86EEA825671E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GAV7</accession>
    <name>A0A836GAV7_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_04790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="protein sequence ID" value="KAG5478557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5478557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="165" mass="18586" checksum="B956F8D178BF4B2A" modified="2021-09-29" version="1">MLSSQSSTAALWSACVVIVFTCAFSAALFFVTVRQLCEHVNAIQHSAVAATLILVAYVLSNVLCVSYNGLGTALQTFAKEHEQDLPQPLFYMIAAIRPLVARVGLTDTMWMACLLFSAYGVTKVWRHMIDITRLLKVSRRRLLLPEMRELRRQEEVAKGKVQKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GBB4</accession>
    <name>A0A836GBB4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutamamyl carboxypeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_03304</name>
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    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
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    <reference evidence="4 5" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
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                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Jariyapan N."/>
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                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067204649.1"/>
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            <end position="141"/>
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        </location>
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        <location>
            <begin position="112"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5469224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="322" mass="35084" checksum="544EEF4B3E287B02" modified="2021-09-29" version="1">MYYGGYDQSYGGNPGYAGGFAGNMRDYNYQQQIHYQADGGYNPYGQQDMRAQQPMWTGVAGGGGPSPMGGSSLGGCPDNNGYVPLGEDDHPTALMSMKSFTGPPPDTERKQSTVTRSRSIASRSSKGGNTGMARHGSVFFSARERDTQVAISTRGEMSARALDEEESEELKQYYGDMACRNEERRMDGLRAVRSYRGDIEDGEDVGKPRRVTNRRNVDGRSATGYGGINFKRKAAMRNGEQWGDVEIRSKPTGGGDYSRSIERSGGQQLMTQPPPMVGSGMYMVPAVVEEGPVMPLIYQQGDVHSHSNMSDAFSDADEDADF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836GDT0_9TRYP</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">LSCM4_03195</name>
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        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Trypanosomatidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060761.1">
        <property type="nucleotide sequence ID" value="XM_067205209.1"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A836GDT0"/>
    <dbReference type="GeneID" id="92359143"/>
    <dbReference type="KEGG" id="loi:92359143"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="526"/>
            <end position="601"/>
        </location>
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        <location>
            <begin position="157"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="358"/>
            <end position="374"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="586"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5471644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="639" mass="68791" checksum="149543C5AFE297DD" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GEE9</accession>
    <name>A0A836GEE9_9TRYP</name>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
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                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000020">
        <property type="protein sequence ID" value="KAG5480477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063808.1">
        <property type="nucleotide sequence ID" value="XM_067208168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GEE9"/>
    <dbReference type="GeneID" id="92362102"/>
    <dbReference type="KEGG" id="loi:92362102"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="735"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="881"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="759"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="779"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5480477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="977" mass="102904" checksum="7D3AB6515798A814" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GH75</accession>
    <name>A0A836GH75_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PSP1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_00755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058931.1">
        <property type="nucleotide sequence ID" value="XM_067202830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GH75"/>
    <dbReference type="GeneID" id="92356764"/>
    <dbReference type="KEGG" id="loi:92356764"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047767">
        <property type="entry name" value="PSP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007557">
        <property type="entry name" value="PSP1_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041131">
        <property type="entry name" value="RicT_YaaT_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830">
        <property type="entry name" value="PROTEIN PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830:SF5">
        <property type="entry name" value="PSP1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04468">
        <property type="entry name" value="PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51411">
        <property type="entry name" value="PSP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP1 C-terminal" evidence="1">
        <location>
            <begin position="151"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5465300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="241" mass="27077" checksum="17A9B125230916BD" modified="2021-09-29" version="1">MLATLTDITNVQAPLPQPQKVKVVTVSGIPAVPAVVRRPVARHNPYQWKCLPAGIHSAADMMADLEAAYAVPVQELFQEKEDRAPPAPGGPSVCNTLVQFKCHQAEFASTMQLDKGQYVVVQGDRGIDIGVVIRINTGAQKTYVERTGPVGSILRYATQREVDYWATDLKDAEAMAAAFCQAKARAHGLPMEIAYAEYQFDKKKLTFYYEARTRIDFVQLLKELYREYGCRIWMEKLRNHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GKH4</accession>
    <name>A0A836GKH4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Histone acetyltransferase</fullName>
            <ecNumber evidence="2 8">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_04836</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="2 8"/>
    <dbReference type="EMBL" id="JAFHLR010000014">
        <property type="protein sequence ID" value="KAG5483687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064626.1">
        <property type="nucleotide sequence ID" value="XM_067206817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GKH4"/>
    <dbReference type="SMR" id="A0A836GKH4"/>
    <dbReference type="GeneID" id="92360751"/>
    <dbReference type="KEGG" id="loi:92360751"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000779">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025995">
        <property type="entry name" value="Tudor-knot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF161">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11717">
        <property type="entry name" value="Tudor-knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="10">
        <location>
            <begin position="145"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5483687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="525" mass="57976" checksum="D0B75632C7D965B5" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GKT9</accession>
    <name>A0A836GKT9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cation efflux protein transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_04201</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
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                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Cation transporter, putative"/>
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    </dbReference>
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        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
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        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
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        <property type="entry name" value="Msc2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
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        <location>
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            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="66"/>
            <end position="83"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="112"/>
            <end position="129"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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        <source>
            <dbReference type="Pfam" id="PF01545"/>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
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    </evidence>
    <sequence length="611" mass="65888" checksum="C8E2C33695DBBCC3" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Leishmania orientalis</name>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
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            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="EMBL" id="KAG5467745.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GLL4</accession>
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            <fullName evidence="4">DUF1648 domain-containing protein</fullName>
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        <name type="scientific">Leishmania orientalis</name>
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    <reference evidence="3" key="1">
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            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
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            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <dbReference type="EMBL" id="KAG5474669.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062332.1">
        <property type="nucleotide sequence ID" value="XM_067207029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GLQ1"/>
    <dbReference type="SMR" id="A0A836GLQ1"/>
    <dbReference type="GeneID" id="92360963"/>
    <dbReference type="KEGG" id="loi:92360963"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="41"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="RCC1-like" evidence="4">
        <location>
            <begin position="44"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="209"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="280"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="332"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="478"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="540"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="596"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="664"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="714"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5476099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="850" mass="90954" checksum="83402921D9E30174" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GLZ3</accession>
    <name>A0A836GLZ3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_04058</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061985.1">
        <property type="nucleotide sequence ID" value="XM_067206048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GLZ3"/>
    <dbReference type="SMR" id="A0A836GLZ3"/>
    <dbReference type="GeneID" id="92359982"/>
    <dbReference type="KEGG" id="loi:92359982"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007255">
        <property type="entry name" value="COG8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21311">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21311:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04124">
        <property type="entry name" value="Dor1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="483"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5474879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="530" mass="57881" checksum="5EEEB2D013214915" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GN38</accession>
    <name>A0A836GN38_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Membrane transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_04151</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062077.1">
        <property type="nucleotide sequence ID" value="XM_067206140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GN38"/>
    <dbReference type="SMR" id="A0A836GN38"/>
    <dbReference type="GeneID" id="92360074"/>
    <dbReference type="KEGG" id="loi:92360074"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11206">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="390"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="427"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="474"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="510"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="539"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="568"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="688"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="731"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="759"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="786"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="171"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5475569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="892" mass="98064" checksum="D0205B1C80444717" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GNY2</accession>
    <name>A0A836GNY2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABC1 atypical kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_02446</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060027.1">
        <property type="nucleotide sequence ID" value="XM_067204475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GNY2"/>
    <dbReference type="SMR" id="A0A836GNY2"/>
    <dbReference type="GeneID" id="92358409"/>
    <dbReference type="KEGG" id="loi:92358409"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13969">
        <property type="entry name" value="ADCK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045307">
        <property type="entry name" value="ADCK1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF37">
        <property type="entry name" value="ABC1 FAMILY PROTEIN C10F6.14C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="3">
        <location>
            <begin position="113"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="320"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5469050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="655" mass="73526" checksum="F4C63B726E5D9D56" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GNZ9</accession>
    <name>A0A836GNZ9_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060057.1">
        <property type="nucleotide sequence ID" value="XM_067204505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GNZ9"/>
    <dbReference type="GeneID" id="92358439"/>
    <dbReference type="KEGG" id="loi:92358439"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5469080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="508" mass="55845" checksum="2663EECE43F0650D" modified="2021-09-29" version="1">MQCGASWGRLLSRPKRVSLWRGFRSGKQVDGAWASNPQCSARYVRTSSASFDSATAPFTTSSRASPFHDVFVSEFSAKILSSPHRDITHVPYGDWFALYVQARKHWHSLESASTCVTPATCEGRKEKSEQAEVLEARVRDAKQSIDALLLSSLFARHWTEVQTVTTSSSSPLSTYRWWWHQDSLFSGPAPANAQDGDAVSPPLELCTPGFLTEPLLGGNHLRLWMEDIRASAGATDAAHAATAVPTAILPFSSLWVVKQSAYWRPSAAAGAVVVDNSGAGSKSREAPVFTLQERQGRQAILQSLDQLLQLQRDAVEGPQGTFGFPADQLQRVCVLSPTQEWELLCALPRYRQALCRPARSEPPASANVSDDSAAACVSPPRWLSLSYLCEDTSTRLAYYAHMLSWWWQLRSSTNAPAIEAAPVAVRVLSPATEHAHLRSLSLFSLHEQSCMKAALQRRRVARHQSSSSAASGASSAATVHEQARKGCIDAVRRMSRREENIRQSFLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GR76</accession>
    <name>A0A836GR76_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Guanine nucleotide-binding protein subunit beta-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_05844</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063547.1">
        <property type="nucleotide sequence ID" value="XM_067207774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GR76"/>
    <dbReference type="GeneID" id="92361708"/>
    <dbReference type="KEGG" id="loi:92361708"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030621">
        <property type="term" value="F:U4 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19846:SF0">
        <property type="entry name" value="PRE-MRNA PROCESSING FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19846">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="313"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="349"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="438"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="546"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="598"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5479836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="616" mass="64143" checksum="F8307CB0BE7E438A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GRI8</accession>
    <name>A0A836GRI8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Leucine-rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_01973</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061048.1">
        <property type="nucleotide sequence ID" value="XM_067204011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GRI8"/>
    <dbReference type="GeneID" id="92357945"/>
    <dbReference type="KEGG" id="loi:92357945"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
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            <dbReference type="ARBA" id="ARBA00022737"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        </source>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
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        <name type="scientific">Leishmania orientalis</name>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
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            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the adenylate kinase family.</text>
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    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <source>
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        <source>
            <dbReference type="RuleBase" id="RU003330"/>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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</entry>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5464951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1076" mass="118386" checksum="14AABA5A40A7F391" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GUA7</accession>
    <name>A0A836GUA7_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_00629</name>
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    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Euglenozoa</taxon>
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            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058807.1">
        <property type="nucleotide sequence ID" value="XM_067202706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GUA7"/>
    <dbReference type="GeneID" id="92356640"/>
    <dbReference type="KEGG" id="loi:92356640"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5465176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="159" mass="16565" checksum="997EF05505156017" modified="2021-09-29" version="1">MRGGGPAAGTAVQITRSATEKLNAAIHGDEVGATNEYSLAGLVVVHRLGVVCQSRRASGWGLPRWSSGHPTSGTGSLSRPCSAVRSSHICNGTLRTVFGRARHCPSARQPRGSLPLRCLAGGSDPERTRRTPRVGSPDCTEQAPPCRASSGVCRGLRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GWI3</accession>
    <name>A0A836GWI3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_01541</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059281.1">
        <property type="nucleotide sequence ID" value="XM_067203590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GWI3"/>
    <dbReference type="SMR" id="A0A836GWI3"/>
    <dbReference type="GeneID" id="92357524"/>
    <dbReference type="KEGG" id="loi:92357524"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15730">
        <property type="entry name" value="FYVE_EEA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23164">
        <property type="entry name" value="EARLY ENDOSOME ANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23164:SF30">
        <property type="entry name" value="EARLY ENDOSOME ANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="13"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="79"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5466391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="295" mass="31761" checksum="E1C61B9CBB459C63" modified="2021-09-29" version="1">MGEKQSKGYWQEDEDAPVCNGCGRVFSTTLRRHHCRNCGYVLCGDCSRHRAAIPMRGITNPERVCDACYLALRSSSITGSGLSRGGQGPTGNPSEAPERPAAWAAGSTAGGASVDPSTPDATGISTAMQSPSAGSALTEEQRKAEVYYRSLYGGDQGDDSAVGTAGVRQETISPEALERERLIQRWNTVRQATVYVDILVQQSERVEPDTAVEYSRETEALTLEPEVPITQLGIRMLPLPRPTTDSARYLVEPVTTMGMSGTTLEKMTADLTQRLATRIPAHGTARVSADDFVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GWU6</accession>
    <name>A0A836GWU6_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059160.1">
        <property type="nucleotide sequence ID" value="XM_067203469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GWU6"/>
    <dbReference type="GeneID" id="92357403"/>
    <dbReference type="KEGG" id="loi:92357403"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051181">
        <property type="entry name" value="CAF1_poly(A)_ribonucleases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15092">
        <property type="entry name" value="POLY A -SPECIFIC RIBONUCLEASE/TARGET OF EGR1, MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15092:SF46">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5466270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="677" mass="73245" checksum="D3A9393C874D8AE5" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GXA3</accession>
    <name>A0A836GXA3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Membrane-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_03665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061598.1">
        <property type="nucleotide sequence ID" value="XM_067205661.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92359595"/>
    <dbReference type="KEGG" id="loi:92359595"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032302646" description="Membrane-associated protein" evidence="2">
        <location>
            <begin position="31"/>
            <end position="1425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1351"/>
            <end position="1373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5473595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1425" mass="153010" checksum="70643DFA8CC8B094" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GYB7</accession>
    <name>A0A836GYB7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Coatomer subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LSCM4_05657</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 10">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10 11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10 11">Cytoplasmic vesicle</location>
            <location evidence="10 11">COPI-coated vesicle membrane</location>
            <topology evidence="10 11">Peripheral membrane protein</topology>
            <orientation evidence="10 11">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10 11">Golgi apparatus membrane</location>
            <topology evidence="10 11">Peripheral membrane protein</topology>
            <orientation evidence="10 11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000016">
        <property type="protein sequence ID" value="KAG5482399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064405.1">
        <property type="nucleotide sequence ID" value="XM_067207591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GYB7"/>
    <dbReference type="GeneID" id="92361525"/>
    <dbReference type="KEGG" id="loi:92361525"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051645">
        <property type="term" value="P:Golgi localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09254">
        <property type="entry name" value="AP_delta-COPI_MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14830">
        <property type="entry name" value="Delta_COP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000003">
        <property type="entry name" value="Coatomer subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027059">
        <property type="entry name" value="Coatomer_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121:SF0">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="13">
        <location>
            <begin position="297"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="139"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG5482399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="535" mass="57810" checksum="C67008ADB9A4ED51" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GYB9</accession>
    <name>A0A836GYB9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">10 kDa heat shock protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_05043</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GroES chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062320.1">
        <property type="nucleotide sequence ID" value="XM_067207017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GYB9"/>
    <dbReference type="SMR" id="A0A836GYB9"/>
    <dbReference type="GeneID" id="92360951"/>
    <dbReference type="KEGG" id="loi:92360951"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.33.40:FF:000014">
        <property type="entry name" value="10 kDa heat shock protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="entry name" value="GroES chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772:SF0">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5476087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="100" mass="10703" checksum="89F353D6AFCB44A9" modified="2021-09-29" version="1">MFRFTAPALKKLQPLGQRVLVKRMQAAKQTKAGILIPEQVAGKVNEGTVVAVAAGSKDWTPTVKVNDAVLLPEYGGSAVKVDGEELYLYDESMLLGVLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H2A2</accession>
    <name>A0A836H2A2_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060022.1">
        <property type="nucleotide sequence ID" value="XM_067204470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H2A2"/>
    <dbReference type="GeneID" id="92358404"/>
    <dbReference type="KEGG" id="loi:92358404"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="638"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="776"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="648"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="825"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5469045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="841" mass="90355" checksum="46451779EF56E5BA" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H2J6</accession>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="1" type="ORF">LSCM4_06674</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000010">
        <property type="protein sequence ID" value="KAG5485716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065300.1">
        <property type="nucleotide sequence ID" value="XM_067208589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H2J6"/>
    <dbReference type="GeneID" id="92362523"/>
    <dbReference type="KEGG" id="loi:92362523"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5485716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="67" mass="7702" checksum="B25F8EC82FAECCEC" modified="2021-09-29" version="1">MHRSSVLRRHPYTIDISSLREANGRNEVPRKKCLTQIALQSARQAWCKTQDLLAFFFPQGYRGGPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H4Q6</accession>
    <name>A0A836H4Q6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="10">2.7.8.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LSCM4_06276</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12593"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60110"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the CDP-alcohol phosphatidyltransferase class-II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.5" evidence="10"/>
    <dbReference type="EMBL" id="JAFHLR010000007">
        <property type="protein sequence ID" value="KAG5486811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065605.1">
        <property type="nucleotide sequence ID" value="XM_067208200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H4Q6"/>
    <dbReference type="GeneID" id="92362134"/>
    <dbReference type="KEGG" id="loi:92362134"/>
    <dbReference type="UniPathway" id="UPA00084">
        <property type="reaction ID" value="UER00503"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09137">
        <property type="entry name" value="PLDc_PGS1_euk_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016270">
        <property type="entry name" value="PGS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586:SF1">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00614">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033028438" description="CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase" evidence="12">
        <location>
            <begin position="21"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="13">
        <location>
            <begin position="303"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="639"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="660"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG5486811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="754" mass="81646" checksum="EDDAF1FC6EAB32B0" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H565</accession>
    <name>A0A836H565_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA topoisomerase</fullName>
            <ecNumber evidence="3">5.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_05723</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="3"/>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063428.1">
        <property type="nucleotide sequence ID" value="XM_067207655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H565"/>
    <dbReference type="SMR" id="A0A836H565"/>
    <dbReference type="GeneID" id="92361589"/>
    <dbReference type="KEGG" id="loi:92361589"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01028">
        <property type="entry name" value="TOPRIM_TopoIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.290.10:FF:000005">
        <property type="entry name" value="DNA topoisomerase 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.140:FF:000008">
        <property type="entry name" value="DNA topoisomerase 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="entry name" value="Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="entry name" value="Topoisomerase I, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="entry name" value="Topoisomerase I, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42785:SF1">
        <property type="entry name" value="DNA TOPOISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42785">
        <property type="entry name" value="DNA TOPOISOMERASE, TYPE IA, CORE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="Prokaryotic type I DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52039">
        <property type="entry name" value="TOPO_IA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="8">
        <location>
            <begin position="10"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IA-type catalytic" evidence="9">
        <location>
            <begin position="183"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="388"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="760"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="760"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="772"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="800"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5479717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="814" mass="89506" checksum="129F6AD1B8FA5CF6" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H5A6</accession>
    <name>A0A836H5A6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_06842</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000009">
        <property type="protein sequence ID" value="KAG5486134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065465.1">
        <property type="nucleotide sequence ID" value="XM_067208754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H5A6"/>
    <dbReference type="SMR" id="A0A836H5A6"/>
    <dbReference type="GeneID" id="92362688"/>
    <dbReference type="KEGG" id="loi:92362688"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000002">
        <property type="entry name" value="Cytochrome b5 type B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359:SF14">
        <property type="entry name" value="CYTOCHROME B5 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="9">
        <location>
            <begin position="3"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5486134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="117" mass="13164" checksum="95C010008EFBFA1F" modified="2021-09-29" version="1">MTPNYIHLSEVEKHIREDDLWFIKDFKVYDITKFVDQHPGGVDTLLSVAGKDGTSEFNAVGHSESAVEELARYYIGDIHPDDTEKVQRASIKAANNYFGIAVVLALVAICSFFIFRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H6F9</accession>
    <name>A0A836H6F9_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000020">
        <property type="protein sequence ID" value="KAG5480407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063738.1">
        <property type="nucleotide sequence ID" value="XM_067208098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H6F9"/>
    <dbReference type="SMR" id="A0A836H6F9"/>
    <dbReference type="GeneID" id="92362032"/>
    <dbReference type="KEGG" id="loi:92362032"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="625"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="625"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="635"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5480407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="701" mass="77024" checksum="E3EB3583C1866054" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H7W8</accession>
    <name>A0A836H7W8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glucoamylase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000022">
        <property type="protein sequence ID" value="KAG5479220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063313.1">
        <property type="nucleotide sequence ID" value="XM_067203854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H7W8"/>
    <dbReference type="GeneID" id="92357788"/>
    <dbReference type="KEGG" id="loi:92357788"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19851:SF7">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19851">
        <property type="entry name" value="OS02G0203500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="249"/>
        </location>
    </feature>
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            <begin position="451"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="986"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="451"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5479220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1221" mass="125347" checksum="CB9D8C8E813F50D7" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="5">Guanine nucleotide-binding protein subunit beta-like protein</fullName>
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        <name evidence="3" type="ORF">LSCM4_02134</name>
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    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
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            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
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            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067204170.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="92358104"/>
    <dbReference type="KEGG" id="loi:92358104"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042411">
        <property type="entry name" value="WDR27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44525">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44525:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 27"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00400">
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        <property type="match status" value="1"/>
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        <property type="match status" value="5"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="625"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="468"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="468"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5472811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="925" mass="97457" checksum="0E6412177694147A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H8B1</accession>
    <name>A0A836H8B1_9TRYP</name>
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        <recommendedName>
            <fullName evidence="2">Calpain catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_07109</name>
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    <organism evidence="3 4">
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000018">
        <property type="protein sequence ID" value="KAG5481397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067209013.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="CYSTEINE PEPTIDASE, PUTATIVE-RELATED"/>
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        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <begin position="277"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5481397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="761" mass="85047" checksum="CB1CA55343CAFB4B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836H979_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="1" type="ORF">LSCM4_06971</name>
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    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
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        <lineage>
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            <taxon>Trypanosomatida</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000017">
        <property type="protein sequence ID" value="KAG5481892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064252.1">
        <property type="nucleotide sequence ID" value="XM_067208878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H979"/>
    <dbReference type="GeneID" id="92362812"/>
    <dbReference type="KEGG" id="loi:92362812"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5481892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="107" mass="11836" checksum="31603F41160B3CEF" modified="2021-09-29" version="1">MFATDMLCDRTERFRQRQPGLGLGACRCSRRPTALRSVAQDTYATSKATSTLMLTPFAARCRYFSSLSACLSRPFFPPVSRLGTLGSFCTRICAALRILPSTDSRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H9B4</accession>
    <name>A0A836H9B4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Par3/HAL N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_08311</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000001">
        <property type="protein sequence ID" value="KAG5488234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066281.1">
        <property type="nucleotide sequence ID" value="XM_067210180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H9B4"/>
    <dbReference type="SMR" id="A0A836H9B4"/>
    <dbReference type="GeneID" id="92364114"/>
    <dbReference type="KEGG" id="loi:92364114"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5488234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="82" mass="9139" checksum="0A0566B0A5FFE775" modified="2021-09-29" version="1">MKITVHVRERIIPLQCGDGTQQVVWLGNAAMIHYDASFGKRFGPPVSIRKEGGVQCDLEARVCDVLEDGQHVFVTLECDRAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H9C4</accession>
    <name>A0A836H9C4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">COX assembly mitochondrial protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_08326</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the CMC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000001">
        <property type="protein sequence ID" value="KAG5488249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066296.1">
        <property type="nucleotide sequence ID" value="XM_067210195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H9C4"/>
    <dbReference type="GeneID" id="92364129"/>
    <dbReference type="KEGG" id="loi:92364129"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013892">
        <property type="entry name" value="Cyt_c_biogenesis_Cmc1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08583">
        <property type="entry name" value="Cmc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5488249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="170" mass="20066" checksum="6E9565112160366E" modified="2021-09-29" version="1">MSTYDKSDQIGYDETDKALNTELEEMMARTPPEVQRHLQHRIHDGILQRMKEETTRKCISFIQKYEQCVNSQKPYNMKLCYPHRDAMNNCAQEVNREENYQRYRIMYLRGELLKYHEKRTAGKMEAFKVQAPDAIRAWKHDYAPKYVHMMEDLGAEPLGNALGATEEAKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HDZ7</accession>
    <name>A0A836HDZ7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Actin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_04991</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062269.1">
        <property type="nucleotide sequence ID" value="XM_067206966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HDZ7"/>
    <dbReference type="GeneID" id="92360900"/>
    <dbReference type="KEGG" id="loi:92360900"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5476036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="269" mass="28493" checksum="6F59B610E35BAB04" modified="2021-09-29" version="1">MDAVESACFIDVGLFTMSIYVSSATDMQKWHIVVPLDAAVTLTTTELLLPGGRHSVALDDLLNAAVKAGRVATMTRVVVLARSWVHPLFYTYVLRWLRAAIPLSTSVSQLPRALFAAECAGVASALVVQCDGAVLFCTPLLDGVICTSLESVWGSVSDSTTVDASLMEDAFSEIGSHLIELVQRDDCDTHLSGNAGADDAGTPHPATLTGAEDLLVAMQKQIKMCQRHELHACLATVVLCGDAATLPAARQCIALLLSASLPDSVLTWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HGA4</accession>
    <name>A0A836HGA4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_05212</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062466.1">
        <property type="nucleotide sequence ID" value="XM_067207163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HGA4"/>
    <dbReference type="GeneID" id="92361097"/>
    <dbReference type="KEGG" id="loi:92361097"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF4">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="910"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="228"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="508"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="659"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="241"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="384"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="520"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5476233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1108" mass="119773" checksum="FD8A6281618587CF" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HI85</accession>
    <name>A0A836HI85_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Guanine nucleotide-binding protein subunit beta-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_04543</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062736.1">
        <property type="nucleotide sequence ID" value="XM_067206527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HI85"/>
    <dbReference type="SMR" id="A0A836HI85"/>
    <dbReference type="GeneID" id="92360461"/>
    <dbReference type="KEGG" id="loi:92360461"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032847">
        <property type="entry name" value="PRPF17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="265"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="353"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5477325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="521" mass="56364" checksum="0512D006CC79D240" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HI97</accession>
    <name>A0A836HI97_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ankyrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_04441</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062634.1">
        <property type="nucleotide sequence ID" value="XM_067206425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HI97"/>
    <dbReference type="SMR" id="A0A836HI97"/>
    <dbReference type="GeneID" id="92360359"/>
    <dbReference type="KEGG" id="loi:92360359"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050889">
        <property type="entry name" value="Dendritic_Spine_Reg/Scaffold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166:SF48">
        <property type="entry name" value="PROTEIN VAPYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166">
        <property type="entry name" value="ROLLING PEBBLES, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="102"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5477223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="27704" checksum="D394E96A935088C3" modified="2021-09-29" version="1">MLLEPSFQLTDLIQAVVEGDLSTLMENVTPSNVNYTDPHHRLSLVMWAATLGRLPTTQLLLSRGASLAQVDRHGFTILHRAVWSADVSIVQTVLFTSPISAVTSSSGAGTTGAPPSFISSQQPSSSPLTWRPGAQRLVNAVHPASGRTPLMLAALSGHAHVARFLLVTCAADPYLRDSYNLTAVDLAAVCGHLDVVRLLLNLTVAPNGATYSAADVFPTAQCNAEEYIEIAKTIPQRERLCSVNKLLNENLAEASRVAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HIK5</accession>
    <name>A0A836HIK5_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_04592</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062784.1">
        <property type="nucleotide sequence ID" value="XM_067206575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HIK5"/>
    <dbReference type="GeneID" id="92360509"/>
    <dbReference type="KEGG" id="loi:92360509"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5477373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="580" mass="63168" checksum="C85E72E5C849D193" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HJ89</accession>
    <name>A0A836HJ89_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_07705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000006">
        <property type="protein sequence ID" value="KAG5487217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065714.1">
        <property type="nucleotide sequence ID" value="XM_067209584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HJ89"/>
    <dbReference type="SMR" id="A0A836HJ89"/>
    <dbReference type="GeneID" id="92363518"/>
    <dbReference type="KEGG" id="loi:92363518"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="283"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="36"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5487217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="446" mass="49216" checksum="2CC9E0FDD30D9777" modified="2021-09-29" version="1">MNGTLGSSGSGGAEAPPVGSLDALTLQTINEQQVIIFRQKELVRTLKERIEELEGQQRQATVKASGAAREANGSKDALSCASEALLRRRVKTLKEENKSLSDRVDELRADLNAVSEQLYAQKLHAQKEKDVWRAKASNAEAKGVAVTHLLEAMDKRNRKLFSQLERLRREGEVTAYECAQWRSLATTAVSHLDQANRRYARDQINSIEEDVHRYAVNRRRSLHVAASASVSLDGETAEETRRMWSRSAQLPKVHPTPHTFLPQKQEPMRSLFHVSHPPPLSQAFLSQSQPHMPSYPLPPPTSEHTKMGTPSSPLSPPRSDTIHERVVESAVPPVLASRRLHAIVNDPLSTLKRMYVAPSPAGVEGQAALTTSPVPEAYPPLNSLIPVQEGRAMPHTPPLPTRYSATDSSAEAETGRWVWPVPGSYNFDSLEVEFDCFGQHSPVGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HKB7</accession>
    <name>A0A836HKB7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome c oxidase subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_04652</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000023">
        <property type="protein sequence ID" value="KAG5478420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063081.1">
        <property type="nucleotide sequence ID" value="XM_067206634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HKB7"/>
    <dbReference type="GeneID" id="92360568"/>
    <dbReference type="KEGG" id="loi:92360568"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5478420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="120" mass="14209" checksum="28695D7AA74E2EF7" modified="2021-09-29" version="1">MMMRRFTSRIAAFAAVAAAVPSRQLHFPLSAPPIEIDYLDSDPLEFAVRTEARKWGFDDLQYMRELAFVRIKENPSIGDFRKMTPEERRDLFWGSDRQDFFRHITFTLTGNPEHLYHRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HKG1</accession>
    <name>A0A836HKG1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Replication protein A C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_07198</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000015">
        <property type="protein sequence ID" value="KAG5482988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064484.1">
        <property type="nucleotide sequence ID" value="XM_067209101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HKG1"/>
    <dbReference type="SMR" id="A0A836HKG1"/>
    <dbReference type="GeneID" id="92363035"/>
    <dbReference type="KEGG" id="loi:92363035"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04478">
        <property type="entry name" value="RPA2_DBD_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000455">
        <property type="entry name" value="Replication Factor A 28 kDa subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040260">
        <property type="entry name" value="RFA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014646">
        <property type="entry name" value="Rfa2/RPA32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014892">
        <property type="entry name" value="RPA_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989">
        <property type="entry name" value="REPLICATION PROTEIN A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989:SF16">
        <property type="entry name" value="REPLICATION PROTEIN A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08784">
        <property type="entry name" value="RPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036949">
        <property type="entry name" value="RPA32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Replication protein A C-terminal" evidence="6">
        <location>
            <begin position="158"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5482988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="257" mass="27515" checksum="EBFA2D96D360AEC8" modified="2021-09-29" version="1">MLASTPGSNFGGAVASSNSSGGQQPQRRMHPIRPLTIKQMLEAQSVGGGVMVVDGREVTQATVVGRVVGYENANMASGGGAITAKHFGYRITDNTGMLVVRQWIDADRMQEPIPLNTHVRASGTVNVWQQTPIVTGTVVSMADSNEINYHMLDAILTHFRLTQGNKRPSQSGASMQNTASAIGVQNMLPGGDNKVLLTDLLVSFIKQHGGAGAGMSMDELTMAAQRYSFTHGDVRTAMRTLAAEGKVYQTHDNRFNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HL39</accession>
    <name>A0A836HL39_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_08299</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCR4/nocturin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000001">
        <property type="protein sequence ID" value="KAG5488222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066269.1">
        <property type="nucleotide sequence ID" value="XM_067210168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HL39"/>
    <dbReference type="GeneID" id="92364102"/>
    <dbReference type="KEGG" id="loi:92364102"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF45">
        <property type="entry name" value="NOCTURNIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="4">
        <location>
            <begin position="158"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="427"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="453"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5488222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="555" mass="62344" checksum="EB4436791AC978B3" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HME9</accession>
    <name>A0A836HME9_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000007">
        <property type="protein sequence ID" value="KAG5486795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065589.1">
        <property type="nucleotide sequence ID" value="XM_067208184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HME9"/>
    <dbReference type="SMR" id="A0A836HME9"/>
    <dbReference type="GeneID" id="92362118"/>
    <dbReference type="KEGG" id="loi:92362118"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5486795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="192" mass="22264" checksum="F9CDDAAD6AEEB09B" modified="2021-09-29" version="1">MLQKTCTSRLLACTPVLLKRSGKPGDLPEYKQAYLPYDTAPTKIELDRERRKFMRAYSGRMEHRKMVEVKNVPQNMYTYGKEGMSIPISIFKDQADPVIGPEWTYPGIFENKIVAQQWFTEELFDREKNNTFESPWQRHVLDNQVKRRLGKVAWRMSMLNIKTIDIFHKERGVSKRPGAADAKSPATPAGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HNN7</accession>
    <name>A0A836HNN7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">UDP-galactose transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_07042</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000018">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="loi:92362881"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="EmrE-like"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
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    </dbReference>
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    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="283"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="418"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <begin position="486"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="512"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="537"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5481331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="561" mass="60650" checksum="B2807FC68A05CA86" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
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        </recommendedName>
    </protein>
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        <name evidence="7" type="ORF">LSCM4_06025</name>
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        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
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    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000011">
        <property type="protein sequence ID" value="KAG5485388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067207951.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92361885"/>
    <dbReference type="KEGG" id="loi:92361885"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039776">
        <property type="entry name" value="Pds5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12663">
        <property type="entry name" value="ANDROGEN INDUCED INHIBITOR OF PROLIFERATION AS3 / PDS5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12663:SF0">
        <property type="entry name" value="PRECOCIOUS DISSOCIATION OF SISTERS 5, ISOFORM A"/>
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    </dbReference>
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        <property type="entry name" value="PDS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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            <end position="1626"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1677"/>
            <end position="1719"/>
        </location>
    </feature>
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        <location>
            <begin position="1609"/>
            <end position="1618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
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            <end position="1719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5485388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1824" mass="193006" checksum="8718CF70E275A928" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HQ03</accession>
    <name>A0A836HQ03_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Membrane insertase YidC/Oxa/ALB C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_06056</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the OXA1/ALB3/YidC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000011">
        <property type="protein sequence ID" value="KAG5485418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065155.1">
        <property type="nucleotide sequence ID" value="XM_067207981.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="92361915"/>
    <dbReference type="KEGG" id="loi:92361915"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032979">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane from matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20069">
        <property type="entry name" value="5TM_Oxa1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
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    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="YidC/Oxa/ALB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428:SF13">
        <property type="entry name" value="60KD INNER MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="OXA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Membrane insertase YidC/Oxa/ALB C-terminal" evidence="7">
        <location>
            <begin position="159"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5485418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="441" mass="50119" checksum="80E488D74BC11D9F" modified="2021-09-29" version="1">MLLGSRLARAPAAISVAPVLRSCALVTSACRRLSAPHNRTRTLSSLSSSTSCGYGVDSGGGIAVALHAQQRGISWNLLKWGRTDVGRSTNPQLEEELPEIFASQPTEVDDYIRPDKSLFERLEDFWDWAVSFLQPVEKQVEIMRSLRHDGFMSHDLGGWGHVFFFYGVCMRVLTLIPSLYSHRNSLRMAHIGPQISEITNNQNKVKNDRTFSSAEKRVIKDGYNRMKYALCKKHRCSQWKSFLTVFTAPITVSAFLSIRRLAMYETDLEMAPFLWVKDLTMPDPTYTLPAICAGMFLLNFEMNQRMQRGGRSSSGLYVRWAVRASSVIGIYFFASQPSAMFAYWIGLSTAGLLQPILLRWQPFRDFFQFPEPPQAAKLHIISEVKGPSLYERLFATQEEKIRLEQQRKADRIKNSAARIETVNDYEVVFDDAKDTASGKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HQ19</accession>
    <name>A0A836HQ19_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_08357</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000001">
        <property type="protein sequence ID" value="KAG5488280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066327.1">
        <property type="nucleotide sequence ID" value="XM_067210226.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836HQ19"/>
    <dbReference type="GeneID" id="92364160"/>
    <dbReference type="KEGG" id="loi:92364160"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000044">
        <property type="entry name" value="TBC Kinase homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF168">
        <property type="entry name" value="TBC DOMAIN-CONTAINING PROTEIN KINASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="1221"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="1766"/>
            <end position="1794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="639"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="732"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="652"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="772"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5488280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1800" mass="190376" checksum="6FF1B9B5CF96A54E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HSM8</accession>
    <name>A0A836HSM8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="14">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LSCM4_06324</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="14"/>
    <dbReference type="EMBL" id="JAFHLR010000007">
        <property type="protein sequence ID" value="KAG5486858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065652.1">
        <property type="nucleotide sequence ID" value="XM_067208247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HSM8"/>
    <dbReference type="SMR" id="A0A836HSM8"/>
    <dbReference type="GeneID" id="92362181"/>
    <dbReference type="KEGG" id="loi:92362181"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000104">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF486">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 14" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 14" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="12 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="369"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="825"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="849"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="890"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="930"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="968"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1000"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="15">
        <location>
            <begin position="82"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG5486858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1114" mass="123356" checksum="510C6DDACB8DEE9A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HTN6</accession>
    <name>A0A836HTN6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S ribosomal protein L39</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_03682</name>
        <name evidence="5" type="ORF">LSCM4_05656</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">LSCM4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFHLR010000016">
        <property type="protein sequence ID" value="KAG5482398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061615.1">
        <property type="nucleotide sequence ID" value="XM_067205678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HTN6"/>
    <dbReference type="SMR" id="A0A836HTN6"/>
    <dbReference type="GeneID" id="92359612"/>
    <dbReference type="KEGG" id="loi:92359612"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1620.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein-like L39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1620.10">
        <property type="entry name" value="Ribosomal protein L39e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00629">
        <property type="entry name" value="Ribosomal_eL39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000077">
        <property type="entry name" value="Ribosomal_eL39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020083">
        <property type="entry name" value="Ribosomal_eL39_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023626">
        <property type="entry name" value="Ribosomal_eL39_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19970:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19970">
        <property type="entry name" value="RIBOSOMAL PROTEIN L39E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00832">
        <property type="entry name" value="Ribosomal_L39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48662">
        <property type="entry name" value="Ribosomal protein L39e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00051">
        <property type="entry name" value="RIBOSOMAL_L39E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5473612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5482398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="51" mass="6486" checksum="6E3038043A4AAC18" modified="2021-09-29" version="1">MGRFKPLAVKKKYAKKMNQNKPVPYWIRLRTGNRIKWNEKRRHWRRTKLNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HU09</accession>
    <name>A0A836HU09_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_08053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000005">
        <property type="protein sequence ID" value="KAG5487608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065896.1">
        <property type="nucleotide sequence ID" value="XM_067209929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HU09"/>
    <dbReference type="SMR" id="A0A836HU09"/>
    <dbReference type="GeneID" id="92363863"/>
    <dbReference type="KEGG" id="loi:92363863"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40736:SF3">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5487608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="168" mass="18899" checksum="9FDB2A12E302135A" modified="2021-09-29" version="1">MMSRLLRTLAKPFTVPVAMCARQVAAMDEPLKRHIDAYEARGEDITIAVWREYVDGQRALLPYRWAKLQNEVSYLTSGEMAITDLTFADVLIFVRFLTKCLFIFIVAVMVGRRSVFPSLEPTSPFVEEVVKNWQPNRLRRVAGADYIAREQAAAADAAADEAVITSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HUV3</accession>
    <name>A0A836HUV3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C6H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_08283</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000003">
        <property type="protein sequence ID" value="KAG5488058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066185.1">
        <property type="nucleotide sequence ID" value="XM_067210152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HUV3"/>
    <dbReference type="GeneID" id="92364086"/>
    <dbReference type="KEGG" id="loi:92364086"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031615">
        <property type="entry name" value="Zfn-C6H2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15801">
        <property type="entry name" value="zf-C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52013">
        <property type="entry name" value="ZF_C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C6H2-type" evidence="3">
        <location>
            <begin position="9"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="79"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="726"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="884"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="949"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="237"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="897"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="962"/>
            <end position="983"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS52013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5488058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="983" mass="105556" checksum="46853947E2247A3C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HV96</accession>
    <name>A0A836HV96_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_08345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000001">
        <property type="protein sequence ID" value="KAG5488268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066315.1">
        <property type="nucleotide sequence ID" value="XM_067210214.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92364148"/>
    <dbReference type="KEGG" id="loi:92364148"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216:SF65">
        <property type="entry name" value="PAXILLIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216">
        <property type="entry name" value="PAXILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1034"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1139"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1196"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1382"/>
            <end position="1542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1196"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1411"/>
            <end position="1425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1432"/>
            <end position="1442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1457"/>
            <end position="1466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1473"/>
            <end position="1491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5488268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1542" mass="161671" checksum="A612762DF67D0677" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HVA9</accession>
    <name>A0A836HVA9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">type I protein arginine methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.319</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LSCM4_07689</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48096"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11991"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61897"/>
            <dbReference type="EC" id="2.1.1.319"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:48097"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-arginyl-[protein] + S-adenosyl-L-methionine = N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11990"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65280"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:48101"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.319" evidence="2"/>
    <dbReference type="EMBL" id="JAFHLR010000012">
        <property type="protein sequence ID" value="KAG5484916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065028.1">
        <property type="nucleotide sequence ID" value="XM_067209568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HVA9"/>
    <dbReference type="SMR" id="A0A836HVA9"/>
    <dbReference type="GeneID" id="92363502"/>
    <dbReference type="KEGG" id="loi:92363502"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035242">
        <property type="term" value="F:protein-arginine omega-N asymmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.160.11:FF:000001">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000034">
        <property type="entry name" value="Protein arginine N-methyltransferase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF53">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="11">
        <location>
            <begin position="87"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="12">
        <location>
            <begin position="193"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG5484916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="369" mass="42257" checksum="EC09843242D2A363" modified="2021-09-29" version="1">MRTLRLFHRSHPFLLKQPRISRAFCMLSTEQCEQAAAEGAVSKMTTANKDYYFDSYSHYGIHMEMLKDYHRTTSYRDAIWRNAYMFKDKVVLDVGCGTGILSMFAARAGARKVIGIDCSNVAIQARQIVQDNGFGDVITIIQGKVEELDLNEKVDIIISEWMGYFLLYESMLNTVLYARDHWGAPTVKILPSNANMYACGITDPQYVEQKFDIWNDVSGLNFSYFKRLSYIEPLIDTVNPEQIITDIVPFFSFDIDTVTEAELSFASTFTLEAKQGDFVHAISVHFDTPFYAGHDPVVLNTSPLAQPTHWRQTVLYLFHPLIMKRGERANFAMKCVPNPGNPRDLDIALRIDFDGELQACHYDQDFRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HWR0</accession>
    <name>A0A836HWR0_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_06654</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
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    </organism>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG5485696.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067208569.1"/>
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            <begin position="567"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5485696.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="591" mass="65551" checksum="54C50A43EF7D7A0C" modified="2021-09-29" version="1"> </sequence>
</entry>
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        <name type="scientific">Leishmania orientalis</name>
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    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="8">May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.</text>
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        <text evidence="7 8">Belongs to the SFT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="3">Uncharacterized protein</fullName>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000006">
        <property type="protein sequence ID" value="KAG5487243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067209610.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
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        <property type="entry name" value="TPR-like_helical_dom_sf"/>
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        <property type="entry name" value="B-box zinc-binding domain"/>
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        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
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        <source>
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    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836K6T2_9TRYP</name>
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        <recommendedName>
            <fullName evidence="2">Myb-like domain-containing protein</fullName>
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    <gene>
        <name evidence="3" type="ORF">LSCM4_00698</name>
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    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
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                <person name="Gatherer D."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <end position="224"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5465244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="396" mass="44015" checksum="79F814E20D24DA8C" modified="2021-09-29" version="1">MDDDEFEFPPDQLDDVIANRLSPYQTAMPSPLTAPFEYPAANVPLSMLAQIPFEHLPPTQPKNPQNFSIGQVLRGALSTSHMRALPGGSGAPRAGTSVAPLPHSQRVHQHNPTRSPYLPVGHPQLPSASSEEEERDGEAEETNQLDKGAPEGADGGTALRSAELRVRASRFPNRQARIEWNEGEVRSFYQALSQYGTDFSAIAVLFPGRSRKDIKRLYQRENRQKPKEVQAALHHKHPIDMAAFEVRYEAKKREAQQPVKTKRLNAEELAFLDEIAGRTTLEGSVDVKSDELEVPVPAATLGDVEETTAAPPSRSRKRRDGTHQLGAENEPVSKRSTKEVTPAAENEFDMEQGSLFDMVTRHEREDNASLDTLFAVQLEQEQQHRAASEDADFSFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836K7J9</accession>
    <name>A0A836K7J9_9TRYP</name>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_01241</name>
    </gene>
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            <taxon>Metakinetoplastina</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067203298.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="loi:92357232"/>
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        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM-like"/>
    </dbReference>
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        <property type="entry name" value="ARM-type_fold"/>
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    <dbReference type="InterPro" id="IPR052575">
        <property type="entry name" value="SSU_processome_comp_20"/>
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        <property type="entry name" value="UTP20_dom"/>
    </dbReference>
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        <property type="entry name" value="UTP20_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UTP20"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1995"/>
            <end position="2346"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20" evidence="3">
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            <end position="2844"/>
        </location>
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        <location>
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        </location>
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        </source>
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        <source>
            <dbReference type="Pfam" id="PF20416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5466099.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="4167" mass="456275" checksum="B164FB67AE9A302E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836K947</accession>
    <name>A0A836K947_9TRYP</name>
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        <recommendedName>
            <fullName evidence="5">Gem-associated protein 2</fullName>
        </recommendedName>
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        <name evidence="3" type="ORF">LSCM4_00131</name>
    </gene>
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        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the gemin-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GEM-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12794">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <end position="381"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00025758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5464691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="543" mass="59419" checksum="99A5FDC7E511A4EB" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836KFM7_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_02420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060002.1">
        <property type="nucleotide sequence ID" value="XM_067204450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KFM7"/>
    <dbReference type="SMR" id="A0A836KFM7"/>
    <dbReference type="GeneID" id="92358384"/>
    <dbReference type="KEGG" id="loi:92358384"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000740">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5469025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="441" mass="49373" checksum="1B5AAB691E3797D2" modified="2021-09-29" version="1">MAMFPCNVPYEPNPPPRDNIVTVAMPGITSCRAELSRYTGPDALTVLCNWSDVDSTDPLHLADVGKNRFTGMPFGQRLRRAWRQWQSVVMGWKSHRSERGEDDVAEAPRPTLPEAVLGDGSVSVSATRCTPSSGGASCPLLPISSTVSTAVQAAELGLTDPPVLYRARCRIAPRLIHGVLASPEVAEVRHRGWYRTLNPMHWALTVKELITCWWFSVRPFQWCYSEPGRTNVAGLRDQAAFTREVRRGVRHMETTLTAESRGDTANANELGSTSAVMKKKHLVLFGVSRGATTCFYSAMKLPKEEAQHVSLVLLEAPFDTLDHVINASCLIPRLARWLARSFSDWRGTREEKLAYDFNPQEVHLRCPVAFVMSVKDTRVPMECTQALIDRVRRELVPHIIPAVEVLVLQHSRHPYMAVGNKEDQDAYVAFVERLYDTYCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KGW7</accession>
    <name>A0A836KGW7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Armadillo repeat-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_00595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058774.1">
        <property type="nucleotide sequence ID" value="XM_067202673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KGW7"/>
    <dbReference type="SMR" id="A0A836KGW7"/>
    <dbReference type="GeneID" id="92356607"/>
    <dbReference type="KEGG" id="loi:92356607"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5465143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="373" mass="40810" checksum="1272E521F1F8E746" modified="2021-09-29" version="1">MATINTELSLVRRFHALLQNYESRPAVARRNTLPTLSRFLRSKDRQIRKLSLEAVHLLAEHPENLQLLGNDSDLVDGVVEIYDGAQYDDPELCDLSNITLDLLAPAFRCGDPREKLAARRAMQDSGVASVGAVPLNATPPPQPGSSPEPRELPNAIGEYDTVIGDGHAEAVGDIDQVSIVSGGTGFEVASSSSHLTRRMAEPAPRPAEVIRGVGKDCPLSIVLEIPALHAMTDTSHIEEILQTTRGVISYTITASAHQIRVFLSAFAQAPLQNLLTEAGYENILTNAERMHYQGSDVGNQSLNGSFFYDKYSTRPSYVQSAKKFASNLLNSVMVYRDPKNNSLAARVRQQRAAQEEGGSTTADRIAQAFSRWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KHF9</accession>
    <name>A0A836KHF9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LSCM4_02253</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061323.1">
        <property type="nucleotide sequence ID" value="XM_067204286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KHF9"/>
    <dbReference type="SMR" id="A0A836KHF9"/>
    <dbReference type="GeneID" id="92358220"/>
    <dbReference type="KEGG" id="loi:92358220"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17982">
        <property type="entry name" value="DEXHc_DHX37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003770">
        <property type="entry name" value="ATP-dependent RNA helicase DHR1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000637">
        <property type="entry name" value="ATP-dependent RNA helicase DHX37/DHR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002147">
        <property type="entry name" value="Putative ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF99">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="178"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="544"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="460"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="505"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="80"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG5472927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1029" mass="116492" checksum="BFEDF0251BEC61E2" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KIH4</accession>
    <name>A0A836KIH4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyltransferase 2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_04340</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">LSCM4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062535.1">
        <property type="nucleotide sequence ID" value="XM_067206326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KIH4"/>
    <dbReference type="GeneID" id="92360260"/>
    <dbReference type="KEGG" id="loi:92360260"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43179:SF12">
        <property type="entry name" value="GALACTOFURANOSYLTRANSFERASE GLFT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43179">
        <property type="entry name" value="RHAMNOSYLTRANSFERASE WBBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="5">
        <location>
            <begin position="124"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5477124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="440" mass="51283" checksum="C6E7B74B89EBF8BF" modified="2021-09-29" version="1">MTAARLHIYRGRKAAHMRIFLFTLLFVVGYIAPLAIFYHRSRADTFQDVPRRRELFISDEDFFQCLTERLSYKSDHNQRIPYVLLPVTMDYQDIKQLFCNITVPITYVMFINNGEFRPLRSLLDRLVDELSEYVGKNLFVIHHPENIGYASAVNEGLRHALTFSVDQVPWVFVTNADVRFAPGLLTEFVTRTSELTRNQKARMLRLDEEVTAESKTLKSVTDARFAFRSNTPPIVTASSLPYRIRTMPPEEMKKQFADTYGIFFTDCREFMASFALSRLTIATVGFFDENYYPSYGEDHDYVWRMNALGYKQYVSKPGQFVHFENANVNAGGDSKRYGVIKFTAYSIQSAKFGRMNFQPFRLHYRRSKWFPDSAVLEANKGRKPLPFDGIIPVDMWVLDSERRQSIWEIGENVRCARDYKHYNLNLLQFSVPPMNSTDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KIJ5</accession>
    <name>A0A836KIJ5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Brix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_04118</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062044.1">
        <property type="nucleotide sequence ID" value="XM_067206107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KIJ5"/>
    <dbReference type="SMR" id="A0A836KIJ5"/>
    <dbReference type="GeneID" id="92360041"/>
    <dbReference type="KEGG" id="loi:92360041"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10480:FF:000006">
        <property type="entry name" value="RNA processing factor 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734:SF3">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="125"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5475536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="330" mass="39283" checksum="26FCC03A8CA214EB" modified="2021-09-29" version="1">MGKGARSKRSARPYAKKQYVVDSTAQEVNPELLERYRNTRQPIRKSQLFTEILTQKKDAKRARRESRENERRRLKDKAPVKAAPKTKERKRKVDVTIIDDEKDPEIINDEADDEFAAFFRERKNPKTLITTGEHPCFRTKQLVKELLWLVPNSIYRPRKSYTLKEITQFCSNREFTDLLVVTDRIKEPYNLIVSHLPEGPTATFRVSNFLSYAQLEDPAPRTEHYPELIFKNFDTRLGRRISRMLECLFPATRDYAGRAVATFHNQRDYIFLRTHRYIFDSLQAVRLQEMGPRFTLRLLSLQSGTFDRQFGEYEWYRKKEHDADTLEWYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KJ06</accession>
    <name>A0A836KJ06_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Scaffold protein Nfu/NifU N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_05002</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NifU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062279.1">
        <property type="nucleotide sequence ID" value="XM_067206976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KJ06"/>
    <dbReference type="SMR" id="A0A836KJ06"/>
    <dbReference type="GeneID" id="92360910"/>
    <dbReference type="KEGG" id="loi:92360910"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.70:FF:000004">
        <property type="entry name" value="HIRA-interacting protein 5, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.70">
        <property type="entry name" value="Scaffold protein Nfu/NifU, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014824">
        <property type="entry name" value="Nfu/NifU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036498">
        <property type="entry name" value="Nfu/NifU_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001075">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178">
        <property type="entry name" value="IRON-SULFUR CLUSTER SCAFFOLD PROTEIN NFU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178:SF1">
        <property type="entry name" value="NFU1 IRON-SULFUR CLUSTER SCAFFOLD HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
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                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="11">HRDC domain-containing protein</fullName>
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    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="8">Belongs to the exosome component 10/RRP6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:nuclear polyadenylation-dependent snRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06147">
        <property type="entry name" value="Rrp6p_like_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000059">
        <property type="entry name" value="Exosome complex exonuclease Rrp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.80:FF:000001">
        <property type="entry name" value="Putative exosome component 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="entry name" value="HRDC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012588">
        <property type="entry name" value="Exosome-assoc_fac_Rrp6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045092">
        <property type="entry name" value="Rrp6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049559">
        <property type="entry name" value="Rrp6p-like_exo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12124:SF47">
        <property type="entry name" value="EXOSOME COMPONENT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12124">
        <property type="entry name" value="POLYMYOSITIS/SCLERODERMA AUTOANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08066">
        <property type="entry name" value="PMC2NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
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        <location>
            <begin position="450"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="671"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="96"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="679"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5467948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="740" mass="81140" checksum="EC86C6F23CE367EA" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KKS1</accession>
    <name>A0A836KKS1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA helicase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_05346</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5477951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062858.1">
        <property type="nucleotide sequence ID" value="XM_067207290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KKS1"/>
    <dbReference type="SMR" id="A0A836KKS1"/>
    <dbReference type="GeneID" id="92361224"/>
    <dbReference type="KEGG" id="loi:92361224"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18010">
        <property type="entry name" value="DEXHc_HARP_SMARCAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000073">
        <property type="entry name" value="DNA helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010003">
        <property type="entry name" value="HARP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45766">
        <property type="entry name" value="DNA ANNEALING HELICASE AND ENDONUCLEASE ZRANB3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45766:SF6">
        <property type="entry name" value="SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51467">
        <property type="entry name" value="HARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HARP" evidence="7">
        <location>
            <begin position="56"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="187"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="469"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="718"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="982"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="718"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5477951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1102" mass="118010" checksum="0C806D68B2A91AA3" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KLL0</accession>
    <name>A0A836KLL0_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_02907</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060479.1">
        <property type="nucleotide sequence ID" value="XM_067204927.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92358861"/>
    <dbReference type="KEGG" id="loi:92358861"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18870">
        <property type="entry name" value="PROTEIN TAG-278-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18870:SF9">
        <property type="entry name" value="PROTEIN TAG-278-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="275"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
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                <person name="Al-Salem W.S."/>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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</entry>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
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        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
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            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="18" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <text>ATP + H2O = ADP + phosphate + H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:15377"/>
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            <dbReference type="ChEBI" id="CHEBI:30616"/>
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            <dbReference type="ChEBI" id="CHEBI:456216"/>
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        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>Mg(2+)</name>
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        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
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    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. PIF1 subfamily.</text>
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    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:hydrolase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18037">
        <property type="entry name" value="DEXSc_Pif1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001824">
        <property type="entry name" value="ATP-dependent DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF7">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="726"/>
            <end position="957"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="262"/>
            <end position="327"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="465"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1412"/>
            <end position="1438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
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            <begin position="41"/>
            <end position="52"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="71"/>
            <end position="84"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="262"/>
            <end position="276"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="15">
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            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="465"/>
            <end position="474"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="485"/>
            <end position="496"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="1412"/>
            <end position="1424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00001946"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00009781"/>
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    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
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    <evidence type="ECO:0000256" key="8">
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            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023125"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG5485331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1438" mass="156446" checksum="FFF2A2054D7AD88A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KSU6</accession>
    <name>A0A836KSU6_9TRYP</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_07939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000013">
        <property type="protein sequence ID" value="KAG5484372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064865.1">
        <property type="nucleotide sequence ID" value="XM_067209815.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836KSU6"/>
    <dbReference type="GeneID" id="92363749"/>
    <dbReference type="KEGG" id="loi:92363749"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="789"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1066"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1411"/>
            <end position="1461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="804"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1076"/>
            <end position="1085"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5484372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1548" mass="168138" checksum="E1BDC8A477E19D3F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KT69</accession>
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        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_04557</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">LSCM4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062749.1">
        <property type="nucleotide sequence ID" value="XM_067206540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KT69"/>
    <dbReference type="SMR" id="A0A836KT69"/>
    <dbReference type="GeneID" id="92360474"/>
    <dbReference type="KEGG" id="loi:92360474"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="5"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="160"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="235"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="379"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="457"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="537"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="235"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="471"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="540"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5477338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="573" mass="61269" checksum="7584B18418B11693" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KV36</accession>
    <name>A0A836KV36_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10 13">Homoserine dehydrogenase</fullName>
            <shortName evidence="10">HDH</shortName>
            <ecNumber evidence="4 10 13">1.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">LSCM4_06282</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <reaction evidence="10 13">
            <text>L-homoserine + NADP(+) = L-aspartate 4-semialdehyde + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10 14">Belongs to the homoserine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.3" evidence="4 10 13"/>
    <dbReference type="EMBL" id="JAFHLR010000007">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneID" id="92362140"/>
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    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00063"/>
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        <property type="reaction ID" value="UER00465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Asp/hSer_DH_NAD-bd"/>
    </dbReference>
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        <property type="entry name" value="HDH_cat"/>
    </dbReference>
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        <property type="entry name" value="HDH_CS"/>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="PRK06349.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43331">
        <property type="entry name" value="HOMOSERINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43331:SF1">
        <property type="entry name" value="HOMOSERINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00742">
        <property type="entry name" value="Homoserine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03447">
        <property type="entry name" value="NAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS01042">
        <property type="entry name" value="HOMOSER_DHGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 10 13" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="10 12 13" id="KW-0521">NADP</keyword>
    <keyword evidence="8 10 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10 13" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Aspartate/homoserine dehydrogenase NAD-binding" evidence="16">
        <location>
            <begin position="10"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Homoserine dehydrogenase catalytic" evidence="15">
        <location>
            <begin position="153"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>L-homoserine</name>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
        </ligand>
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            <dbReference type="ARBA" id="ARBA00005056"/>
        </source>
    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00006753"/>
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    </evidence>
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        </source>
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            <dbReference type="Pfam" id="PF03447"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5486817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="366" mass="39616" checksum="3DE12014B512FED6" modified="2021-09-29" version="1">MAIIRAALLGFGTVGQGIYSIVQQRREELKQKLGGAELVIVKVLVRDLHKPNRLLPDDSMSEAALLTDSIEDVFRADVHVIFEATVGEEPAFAYLRRAIVEHRCSVITANKVMFARYGAALQELAASCTPTPPSLPATRVYVGFEATVAAGVPIIKTLQNMCHVQRVRKIEGIVNGTSNYVLTELREHPEKTLEGVLKKAQELGYAEADPTSDVSGQDAFMKLLVMVSIAFGRQPDRSTVPVVGIDTLTPEMLQDARAKGLRYRHVVHASIEAVATSSRSPSSSAVAGEVPPPTGPPHEHLMCSVMPMLLGPEHPLYHMDGTTSAVSVWTDLLGVVTISGPGAGMYPTASAMMEDYAVWMTAFRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KV52</accession>
    <name>A0A836KV52_9TRYP</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_08175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
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            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000002">
        <property type="protein sequence ID" value="KAG5488196.1"/>
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            <begin position="182"/>
            <end position="232"/>
        </location>
    </feature>
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        </location>
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        </location>
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        </location>
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    </feature>
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        </location>
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        </location>
    </feature>
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        <location>
            <begin position="959"/>
            <end position="974"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5488196.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1151" mass="124263" checksum="E0E604E108AEB7BB" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KVZ2</accession>
    <name>A0A836KVZ2_9TRYP</name>
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        <recommendedName>
            <fullName evidence="1">Fe-containing alcohol dehydrogenase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="2" type="ORF">LSCM4_07637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Euglenozoa</taxon>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000012">
        <property type="protein sequence ID" value="KAG5484865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067209517.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="92363451"/>
    <dbReference type="KEGG" id="loi:92363451"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ADH_Fe_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25137">
        <property type="entry name" value="ADH_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-containing alcohol dehydrogenase-like C-terminal" evidence="1">
        <location>
            <begin position="9"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5484865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="87" mass="9653" checksum="41A9079CF4E0AC8D" modified="2021-09-29" version="1">MMRETRLCAAAIDAIRALSAEVEIPSGFKQLGAKEEELPRLANAALLDVRAMFNSRQCTRDNIIGMYCSAMQIKDSGKQVFEPMSGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KXC3</accession>
    <name>A0A836KXC3_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_07145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000018">
        <property type="protein sequence ID" value="KAG5481433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064112.1">
        <property type="nucleotide sequence ID" value="XM_067209049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KXC3"/>
    <dbReference type="GeneID" id="92362983"/>
    <dbReference type="KEGG" id="loi:92362983"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:002564">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042505">
        <property type="entry name" value="DYNC2I1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16022:SF0">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 2 INTERMEDIATE CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16022">
        <property type="entry name" value="WD REPEAT DOMAIN 60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5481433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="907" mass="97201" checksum="D6140A37C3E01331" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KXP9</accession>
    <name>A0A836KXP9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cystathionine beta-synthase</fullName>
            <ecNumber evidence="4">4.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_06868</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-homocysteine + L-serine = L,L-cystathionine + H2O</text>
            <dbReference type="Rhea" id="RHEA:10112"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="4.2.1.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.22" evidence="4"/>
    <dbReference type="EMBL" id="JAFHLR010000017">
        <property type="protein sequence ID" value="KAG5481793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064153.1">
        <property type="nucleotide sequence ID" value="XM_067208779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KXP9"/>
    <dbReference type="SMR" id="A0A836KXP9"/>
    <dbReference type="GeneID" id="92362713"/>
    <dbReference type="KEGG" id="loi:92362713"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004122">
        <property type="term" value="F:cystathionine beta-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000003">
        <property type="entry name" value="Cystathionine beta-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000118">
        <property type="entry name" value="Related to CYS4-cystathionine beta-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="8">
        <location>
            <begin position="16"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="337"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5481793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="367" mass="40068" checksum="60EE57D3AA3FE865" modified="2021-09-29" version="1">MTSANPHAHILANALEAVGNTPCIRLNRVPQKHGIRCEVVAKCEFFNPGGSVKDRIGKQMVLDAEKCGTLKPGSVIVEATSGNTGIGLSLAAAIRGYRMVITMPKKMSHEKETTLQVLGAEVIRTETSLPHDHPDSLIGIARRLRDEKGYVLLDQYKNPSNPGAHYEHTGQEIYDQCGGKVDMVVICTGTGGTITGVAKKLKELNPSVIVVGVDPVGSIIADPEHPSEAILYHVEGIGYDFVPDVCERKYVDRWVKTRDQESFDLALELHREEGLLVGGSSGSAMAGVLEAAKDLRPDQRCVVLFADGIRNYMAKFADVNWMIEHGFRSGEVTRPTYETLQRQLEEAKAKLATYESGAQRKESSEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KXT8</accession>
    <name>A0A836KXT8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_06326</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_067208249.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Calcineurin-like_PHP"/>
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    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
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    <dbReference type="InterPro" id="IPR051134">
        <property type="entry name" value="PPP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 5-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
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        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="6">
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            <begin position="620"/>
            <end position="625"/>
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            <begin position="165"/>
            <end position="184"/>
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    <feature type="region of interest" description="Disordered" evidence="5">
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    <feature type="region of interest" description="Disordered" evidence="5">
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            <begin position="430"/>
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    <feature type="region of interest" description="Disordered" evidence="5">
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            <begin position="853"/>
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    <feature type="region of interest" description="Disordered" evidence="5">
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <dbReference type="Proteomes" id="UP000674143"/>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
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        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
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        <property type="entry name" value="Prot_kinase_dom"/>
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        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="MAPKK KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pkinase"/>
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                <person name="Bates M.D."/>
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        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058302.1">
        <property type="nucleotide sequence ID" value="XM_067202201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836FZC9"/>
    <dbReference type="SMR" id="A0A836FZC9"/>
    <dbReference type="GeneID" id="92356135"/>
    <dbReference type="KEGG" id="loi:92356135"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.20:FF:000007">
        <property type="entry name" value="60S ribosomal protein L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056366">
        <property type="entry name" value="Ribosomal_eL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL24-related N-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5464671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="124" mass="14573" checksum="3AEE54B0D0C9DBBF" modified="2021-09-29" version="1">MRTIECEFSHFAVHPGHGRRYVPFAFLSTKPVLTFSRPKCFALYMRKKNPRFIPWTRTYRRIHRKTTTDRVNRRRAARAVKVQRAIVGADLSYIQEVRATRKEDRSAKAKAVRAEVAERKAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G2R6</accession>
    <name>A0A836G2R6_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_00556</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058735.1">
        <property type="nucleotide sequence ID" value="XM_067202634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G2R6"/>
    <dbReference type="GeneID" id="92356568"/>
    <dbReference type="KEGG" id="loi:92356568"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5465104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="995" mass="107535" checksum="41C2F305DB760B44" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G4T3</accession>
    <name>A0A836G4T3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_01088</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PLPL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5468001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059803.1">
        <property type="nucleotide sequence ID" value="XM_067203153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G4T3"/>
    <dbReference type="GeneID" id="92357087"/>
    <dbReference type="KEGG" id="loi:92357087"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021771">
        <property type="entry name" value="Triacylglycerol_lipase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF66">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE PTL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11815">
        <property type="entry name" value="DUF3336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="7">
        <location>
            <begin position="190"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5468001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="570" mass="62809" checksum="D8D2E154B772E8AB" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G540</accession>
    <name>A0A836G540_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_01635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059374.1">
        <property type="nucleotide sequence ID" value="XM_067203683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G540"/>
    <dbReference type="SMR" id="A0A836G540"/>
    <dbReference type="GeneID" id="92357617"/>
    <dbReference type="KEGG" id="loi:92357617"/>
    <dbReference type="Proteomes" id="UP000674143">
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        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
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    </dbReference>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="549" mass="60449" checksum="6FFB4ACEE8E23B2E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836G7B9_9TRYP</name>
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        <name type="scientific">Leishmania orientalis</name>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <end position="125"/>
        </location>
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            <begin position="126"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5467804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="202" mass="21234" checksum="265C6198F786166D" modified="2021-09-29" version="1">MDFSKYLITVLLNALVIGADQRSLHPLSLPRGRQDGKIAGVDPPYMPGDNGRPGVLVRSANGSSQKYSCSTLSGRAQSAYFAPIECPSSGSAHESNFSLPSISAPSGRLPNKSPAAASPSPTTSSLRSGSEPQIRTSCDSHCGDIMAGPERTFLMALDYLDDACRALTQLSGTELGKLATIPAAPPSKSKTFPGRFSSPRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836G9F4_9TRYP</name>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="scientific">Leishmania orientalis</name>
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    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="loi:92358393"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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            <end position="425"/>
        </location>
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        </location>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF24327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24328"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5469034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="469" mass="49444" checksum="3792097CA21CB669" modified="2021-09-29" version="1">MSQTKPHHHFPKGKRSGTFQSLFGYTSAMSALVWTLLLVCVVANPGVHAAVSVKGAVCIAHLVEWCTNSTMTLMGEELENVAHVRVGATAAEQQQVHCEINYKSSETILCTLTMALSARAGPYHLTLVIPGTAGADDTEVPAGNVLLGAFWGMSHTSFWNPSTTSSVTNQSSNWPSTGDGWTLHGNFDEDKTYTLFFFSSEGEVVAGNPSMVTCASVTHTTSTLTCTIIAANGVMGMYRVLVTESETNAVLLGTTSLPSIAVNPPLPDVVGASGDCAASSAECVTGATLILQGINFNYRKAEYQEFFVGVTEAQRNAISLTPVEVDKNGVTTTLTVADGTPAGSYPVFVRLQVCMMGMMSPLRYVGNLVLKSGDIAGFNMDMPTGSYRETQSASIPPGQAAATILAAILGVLLLAALVALTVVCARGAARRRRSGEVNEYSENVEMELPAAAVPAGKEVGTEGSRFSQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GB35</accession>
    <name>A0A836GB35_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="6" type="ORF">LSCM4_02747</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
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            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
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            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060320.1">
        <property type="nucleotide sequence ID" value="XM_067204768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GB35"/>
    <dbReference type="SMR" id="A0A836GB35"/>
    <dbReference type="GeneID" id="92358702"/>
    <dbReference type="KEGG" id="loi:92358702"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
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        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
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        <property type="entry name" value="STE20_Ser-Thr_kinase"/>
    </dbReference>
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        <property type="entry name" value="MISSHAPEN LIKE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47096:SF1">
        <property type="entry name" value="MISSHAPEN LIKE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="853"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="626"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="626"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="882"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5470054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1137" mass="124806" checksum="E3D9FEF9A054DB59" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GBD9</accession>
    <name>A0A836GBD9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NOL1/NOP2/Sun domain family member 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LSCM4_02928</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a cytidine in rRNA + S-adenosyl-L-methionine = a 5-methylcytidine in rRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61484"/>
            <dbReference type="Rhea" id="RHEA-COMP:15836"/>
            <dbReference type="Rhea" id="RHEA-COMP:15837"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74483"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060500.1">
        <property type="nucleotide sequence ID" value="XM_067204948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GBD9"/>
    <dbReference type="SMR" id="A0A836GBD9"/>
    <dbReference type="GeneID" id="92358882"/>
    <dbReference type="KEGG" id="loi:92358882"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031167">
        <property type="term" value="P:rRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000661">
        <property type="entry name" value="NOL1/NOP2/sun family, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808:SF3">
        <property type="entry name" value="5-METHYLCYTOSINE RRNA METHYLTRANSFERASE NSUN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808">
        <property type="entry name" value="NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="13">
        <location>
            <begin position="87"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="414"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="178"/>
            <end position="184"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG5470234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="426" mass="45876" checksum="97E45A000EF77388" modified="2021-09-29" version="1">MPPSRSAGRGRNKSGTAATAHTKGGFHAKSSARPRTLDEYYGEIYGERWPRLRAAMAEVPRKVALWNRFCQLPFKEATRGLSRVDPNSLVQAFQPSREVNAADSSVTAHHGTGGSDEAKPREEVLAASPGDILHRDGIIAKPPVDAFGIKAYYLLDYASAHVVEQLQVGAFDSVLDMCAAPGGKSIVIGQFLSPDGALTCNEARADRCARLRRNLQEHLPMNYVPWRTTQRDGQTWYDPEAFSRVLVDAPCSSERHLLQQSCGSPLSLREWSEETTANLAALQRMLLQRAIETCRVGGRIVYSTCSISPLENDGVVGEVLQRTRCGVRVVRLSPDPAVAAAAATIAPLKTAGGAGESNVPGAEGCAPHTPLVLGEATAYGRLLLPDTCNGWGPMFFCVLEKTATYKSVASSSSGDDDDYRDSDDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GC89</accession>
    <name>A0A836GC89_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">40S ribosomal protein L14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_01895</name>
        <name evidence="8" type="ORF">LSCM4_01899</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">LSCM4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000022">
        <property type="protein sequence ID" value="KAG5479303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFHLR010000022">
        <property type="protein sequence ID" value="KAG5479307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063396.1">
        <property type="nucleotide sequence ID" value="XM_067203937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GC89"/>
    <dbReference type="SMR" id="A0A836GC89"/>
    <dbReference type="GeneID" id="92357871"/>
    <dbReference type="KEGG" id="loi:92357871"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06088">
        <property type="entry name" value="KOW_RPL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000062">
        <property type="entry name" value="Putative 40S ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039660">
        <property type="entry name" value="Ribosomal_eL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002784">
        <property type="entry name" value="Ribosomal_eL14_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041985">
        <property type="entry name" value="Ribosomal_eL14_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01929">
        <property type="entry name" value="Ribosomal_L14e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="5">
        <location>
            <begin position="10"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein eL14" evidence="6">
        <location>
            <begin position="47"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="162"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5479303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5479307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="175" mass="19980" checksum="263F1E2C8E317A9E" modified="2021-09-29" version="1">MVKSHYIRAGRLVRILRGPRQDRVGVIVDIVDANRVLVENPEDAKMWRHVQNLKNVEPLKYCVSVGRNCSTKALKDALDSSKALEKYAKTRTAARVEAKKACAASTDFERYQLRVARRSRAYWARKVFDEKDAKAPVSWHKVALKRMQKKAAKMDSTEGAKKRMQKAIAARKAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GF87</accession>
    <name>A0A836GF87_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peroxin 19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_01517</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059257.1">
        <property type="nucleotide sequence ID" value="XM_067203566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GF87"/>
    <dbReference type="SMR" id="A0A836GF87"/>
    <dbReference type="GeneID" id="92357500"/>
    <dbReference type="KEGG" id="loi:92357500"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033328">
        <property type="term" value="F:peroxisome membrane targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045046">
        <property type="term" value="P:protein import into peroxisome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.900">
        <property type="entry name" value="Pex19, mPTS binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006708">
        <property type="entry name" value="Pex19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038322">
        <property type="entry name" value="Pex19_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12774">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12774:SF2">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04614">
        <property type="entry name" value="Pex19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="170"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="98"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5466367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="34049" checksum="C166B8EB05A9D77A" modified="2021-09-29" version="1">MSDDDLDALLDEAMDMVDEQERKHEEAVRVRDAKLEDDLQKALDEASGTAGGDADMMKMFMSILGASSSGGADDASLDSFKKGVMSMVSSLEGEENLGEEDKANLERVKELMRVMEEEDIDKANDLLEHMKQEGKLPGGDSAGDADVEEASRRCMEILQQLSNATQGGQPELAAAAPGAASSSSATTLAAPDENGATAPADVDRATEAMASALISTLANPQFVEPIKLMRDSYGPYMDAHRSELSQEDCERYDLQRAKAQEICDLLQNPISGPEDPRLVQLLELMNSYSELGDPPCNLVEYAPKDCRGPSCTSGTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GFA2</accession>
    <name>A0A836GFA2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Peroxin-12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LSCM4_06498</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000019">
        <property type="protein sequence ID" value="KAG5480927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063928.1">
        <property type="nucleotide sequence ID" value="XM_067208416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GFA2"/>
    <dbReference type="GeneID" id="92362350"/>
    <dbReference type="KEGG" id="loi:92362350"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16451">
        <property type="entry name" value="mRING_PEX12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017375">
        <property type="entry name" value="PEX12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12888:SF0">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12888">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 12 PEROXIN-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Pex N-terminal" evidence="15">
        <location>
            <begin position="221"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="370"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG5480927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="461" mass="50578" checksum="873BC6276DF23E78" modified="2021-09-29" version="1">MFESNLPSQINTSSPLPTVVEVQLTTSINQSFYKAFQFAHTLLAEKSDRAAVLLPWSDEIYLAMSGMLERLMLQHADTTISEMIFALRRAEVDGPLAAAPPLSSSLAAASGPSSPGLRPGVSGRYLRWLLLGPPPVTTPEERAMNFINEGTSSQLRVRASAPADGGVGAMESPEVATPAPLVDDVVTGVKAATGSEADAVALSQLKSVELLKAEHAPYGYLRFKPLSRRNKVISLFLLTLKPYVERKVEQWYVRNTDVSVDAVAMRDAYAHRYPHRAALLRFLAQYVYPVYHIVKQGSRFLYMMCFLLELTPYTSPLHRLFGIALRRSTLEDSLATGPRSQRALLVARVVLLLVFCGFRLLDFTRSADGAPSPRQIREEGLPIPPPPALGGDVPLPEDRSSLPKAGECPICRRHVTNAAVCLVSGIVGCYPCLQGYVRDQRACPVTQQSMGVEQVRRIFEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GG28</accession>
    <name>A0A836GG28_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_07073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000018">
        <property type="protein sequence ID" value="KAG5481362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064041.1">
        <property type="nucleotide sequence ID" value="XM_067208978.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92362912"/>
    <dbReference type="KEGG" id="loi:92362912"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="552"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="716"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="951"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1254"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1300"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="722"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1254"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1305"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1337"/>
            <end position="1361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5481362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1662" mass="174668" checksum="B9A90A4BFDD99695" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GG76</accession>
    <name>A0A836GG76_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_03112</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060681.1">
        <property type="nucleotide sequence ID" value="XM_067205129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GG76"/>
    <dbReference type="GeneID" id="92359063"/>
    <dbReference type="KEGG" id="loi:92359063"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5471564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="193" mass="20860" checksum="83C7C7B02E259702" modified="2021-09-29" version="1">MSCLLFGVRYQPEERTLEFDLTDAPLVDVVTDVTVAPCGVAAPLWRTPAMQQGLFYGRNAFILDRPLVFADDRVAIVCCLRVRQQRLSTLAAIASNVLLGSADESAAHCTGPQDTREYMLLFTEVSHTGRDDGQGNGFVYLTSQPLPSLTGGSPTTMGFPLPPQSPTMCLTRAPQRSPPSSLLALSAHALCYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GG85</accession>
    <name>A0A836GG85_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_00125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058316.1">
        <property type="nucleotide sequence ID" value="XM_067202215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GG85"/>
    <dbReference type="GeneID" id="92356149"/>
    <dbReference type="KEGG" id="loi:92356149"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035155">
        <property type="entry name" value="DUF5393"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17371">
        <property type="entry name" value="DUF5393"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5464685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="772" mass="82358" checksum="647C7209A8C881EA" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GI35</accession>
    <name>A0A836GI35_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Complex I-ESSS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">NADH-ubiquinone oxidoreductase ESSS subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">LSCM4_01166</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Complex I is composed of 45 different subunits. Interacts with BCAP31.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB11 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5468077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059879.1">
        <property type="nucleotide sequence ID" value="XM_067203229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GI35"/>
    <dbReference type="SMR" id="A0A836GI35"/>
    <dbReference type="GeneID" id="92357163"/>
    <dbReference type="KEGG" id="loi:92357163"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019329">
        <property type="entry name" value="NADH_UbQ_OxRdtase_ESSS_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10183">
        <property type="entry name" value="ESSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG5468077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="112" mass="13711" checksum="79F10B307EAE3E64" modified="2021-09-29" version="1">MAGWNQKMAKMAFRRSKFRRLAWGDGDPYPYTPRATFRYQWDDWPMWEKMWHLSLGVLGIEFAVWAYYSKLNSRMDWAREEALRRMRLRREAQELMILEGETFSSDIQPDRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GJJ0</accession>
    <name>A0A836GJJ0_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_00469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058649.1">
        <property type="nucleotide sequence ID" value="XM_067202548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GJJ0"/>
    <dbReference type="GeneID" id="92356482"/>
    <dbReference type="KEGG" id="loi:92356482"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="755"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5465018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="891" mass="93532" checksum="EC9D01FC6B3CB5CB" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GJR5</accession>
    <name>A0A836GJR5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PCIF1 WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_00590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058769.1">
        <property type="nucleotide sequence ID" value="XM_067202668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GJR5"/>
    <dbReference type="SMR" id="A0A836GJR5"/>
    <dbReference type="GeneID" id="92356602"/>
    <dbReference type="KEGG" id="loi:92356602"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016422">
        <property type="term" value="F:mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099122">
        <property type="term" value="F:RNA polymerase II C-terminal domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039881">
        <property type="entry name" value="PCIF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022035">
        <property type="entry name" value="PCIF1_WW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21727:SF0">
        <property type="entry name" value="MRNA (2'-O-METHYLADENOSINE-N(6)-)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21727">
        <property type="entry name" value="PHOSPHORYLATED CTD INTERACTING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12237">
        <property type="entry name" value="PCIF1_WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCIF1 WW" evidence="2">
        <location>
            <begin position="340"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="PCIF1 WW" evidence="2">
        <location>
            <begin position="494"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="577"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5465138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="656" mass="70924" checksum="6D78BD301C5AED65" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GJZ8</accession>
    <name>A0A836GJZ8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_00713</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058889.1">
        <property type="nucleotide sequence ID" value="XM_067202788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GJZ8"/>
    <dbReference type="SMR" id="A0A836GJZ8"/>
    <dbReference type="GeneID" id="92356722"/>
    <dbReference type="KEGG" id="loi:92356722"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000003">
        <property type="entry name" value="membrane-associated progesterone receptor component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF76">
        <property type="entry name" value="CALCUTTA CUP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="2">
        <location>
            <begin position="4"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5465258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="113" mass="12605" checksum="4A42162EB7DDAA54" modified="2021-09-29" version="1">MKSFTAEELAKFTGESGTPIYMSVKGKVYDCSSGATFYGPGKSYAVFAGKEVSRCLGKMLISDEEANANWDDLTPEHMQSLDEWAAKFDSKYPVIGMFDPTDEYYARQRTLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GK26</accession>
    <name>A0A836GK26_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Presenilin enhancer-2 subunit of gamma secretase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_02524</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PEN-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060104.1">
        <property type="nucleotide sequence ID" value="XM_067204552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GK26"/>
    <dbReference type="GeneID" id="92358486"/>
    <dbReference type="KEGG" id="loi:92358486"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070765">
        <property type="term" value="C:gamma-secretase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019379">
        <property type="entry name" value="Gamma_Secretase_Asp_P_PEN2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16318">
        <property type="entry name" value="GAMMA-SECRETASE SUBUNIT PEN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16318:SF0">
        <property type="entry name" value="GAMMA-SECRETASE SUBUNIT PEN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10251">
        <property type="entry name" value="PEN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5469127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="131" mass="15066" checksum="715142FA95C126DE" modified="2021-09-29" version="1">MLVRGAFTLDKAERVCRWYYRIGFFGLPWLWGLLWLLFRHYKDESEMIHWYVERAKCYSIAGGAVFVVMSVVLLFAIPPTSTLWVIAPFQDTFQWGYFAVNQSETAGEANNSSSSCDSASFSVKGQDSWRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GLM9</accession>
    <name>A0A836GLM9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="6">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_02670</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="6"/>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5469982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060248.1">
        <property type="nucleotide sequence ID" value="XM_067204696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GLM9"/>
    <dbReference type="SMR" id="A0A836GLM9"/>
    <dbReference type="GeneID" id="92358630"/>
    <dbReference type="KEGG" id="loi:92358630"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06606">
        <property type="entry name" value="STKc_MAPKKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001164">
        <property type="entry name" value="Protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013:SF18">
        <property type="entry name" value="KINASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="313"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="606"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="685"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="861"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1017"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1066"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="606"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="630"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="698"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="889"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="930"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1017"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1092"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5469982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1122" mass="118888" checksum="0A445A4DE7A0BB01" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GLW9</accession>
    <name>A0A836GLW9_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_07989</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000013">
        <property type="protein sequence ID" value="KAG5484422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064915.1">
        <property type="nucleotide sequence ID" value="XM_067209865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GLW9"/>
    <dbReference type="GeneID" id="92363799"/>
    <dbReference type="KEGG" id="loi:92363799"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="767"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="863"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="960"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1139"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="784"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="811"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="864"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="884"/>
            <end position="903"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5484422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1172" mass="123625" checksum="84CBD8A27509479C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GM96</accession>
    <name>A0A836GM96_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein L3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_03007</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060578.1">
        <property type="nucleotide sequence ID" value="XM_067205026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GM96"/>
    <dbReference type="SMR" id="A0A836GM96"/>
    <dbReference type="GeneID" id="92358960"/>
    <dbReference type="KEGG" id="loi:92358960"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000079">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1430.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.960.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000351">
        <property type="entry name" value="Ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.960.10">
        <property type="entry name" value="Ribosomal protein L3, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045077">
        <property type="entry name" value="L3_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044892">
        <property type="entry name" value="Ribosomal_L3_dom_3_arc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_uL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_uL3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5470312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="419" mass="47601" checksum="7AEB45FD8BAA7D99" modified="2021-09-29" version="1">MSHCKFEHPRHGHLGFLPRKRSRQIRGRARAFPKDDATQKPHLTSFMVFKAGMTHIVRDVDRPGSKVNKKEVVEPVTILEAPPMVIVGIVGYRQTPVGLKTIGTVWAHHTSVEFRRRYYKNWKQSAQLAFTRQKQFANTKEGKVAEARTLNAFVKKASVIRVIAHTQLRKLRNHRVGVKKAHVQEIQINGGNVAAKIALAKSLLEKEVRVDSVFQQSEACDVCSVTKGHGTEGVVKRWGVACLPRKTHRGLRKVACIGAWHPARVMYTVARAGQHGYHHRTQLNKKIYQIGRSVAVEPNQATTTYDLTAKTITPMGGFVGYGTVRNDYVMLKGSVSGPRRRVMTLRRPMAPQTSRQLKEKIVLKFIDTSSKIGHGRFQTKKEKNQWFGPLKKDRIRREERLRKERAARAVERKAKTAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GQC6</accession>
    <name>A0A836GQC6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome c oxidase assembly protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_01120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5468033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059835.1">
        <property type="nucleotide sequence ID" value="XM_067203185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GQC6"/>
    <dbReference type="SMR" id="A0A836GQC6"/>
    <dbReference type="GeneID" id="92357119"/>
    <dbReference type="KEGG" id="loi:92357119"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018793">
        <property type="entry name" value="Cyt_c_oxidase_assmbl_Pet191"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10203">
        <property type="entry name" value="Pet191_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5468033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="97" mass="11643" checksum="87672A585259F137" modified="2021-09-29" version="1">MEKEQKSICWRPKNSLIECVVMTKCFEEKESIEDCIGVNDCFLERRNWTLCKMNAVNPRYRLRGNPYDVATEDQKKIEARDERIRQRNLEEEGIFPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GQV1</accession>
    <name>A0A836GQV1_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_04611</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000023">
        <property type="protein sequence ID" value="KAG5478379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063040.1">
        <property type="nucleotide sequence ID" value="XM_067206593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GQV1"/>
    <dbReference type="GeneID" id="92360527"/>
    <dbReference type="KEGG" id="loi:92360527"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5478379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="292" mass="31475" checksum="FAB52A581C83C75D" modified="2021-09-29" version="1">MGDVKVSFAFVTSRSFNCCASTHCGEESAIGVSEPRSEALLNHSRDAILKVLDYDTGYARVFRMTHPHGASMRCVYESLADVMAANSSEVICYTPPPMSAGGVLSLCAMKVLEPADEVPDVLFCQKAAVPRRSAVSLSRWLLINVLMCGSDGVLTVGHVPCAVPVAVGFITRDGVFNSMCALLKMGLECERQLRDCALFCCTIEEKSLVLRDPFFDGACPSQVAIIYGVVDVGEVVLVSAPLLPSVSKARPSVLQAVVVRRYAEDGVTLYDVKEVDTTLVLERLTCTQLVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GR96</accession>
    <name>A0A836GR96_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gamma-butyrobetaine hydroxylase-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_05874</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063577.1">
        <property type="nucleotide sequence ID" value="XM_067207804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GR96"/>
    <dbReference type="GeneID" id="92361738"/>
    <dbReference type="KEGG" id="loi:92361738"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2020.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010376">
        <property type="entry name" value="GBBH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038492">
        <property type="entry name" value="GBBH-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35303">
        <property type="entry name" value="OS02G0197800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35303:SF5">
        <property type="entry name" value="OS02G0197800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06155">
        <property type="entry name" value="GBBH-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-butyrobetaine hydroxylase-like N-terminal" evidence="4">
        <location>
            <begin position="342"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="263"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="421"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5479866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="451" mass="49041" checksum="14C14BB9AF522D19" modified="2021-09-29" version="1">MSQTPGGRGRGTRRRHPSSRPLLSPLHKLGCACSPGSASRSRLRGDVVKQSLFACTPLYVVADAFSYQEGATQRLIAHKAKGFCCGSWCQCCWWLHGHTSCTEVSRYVLCPFVFRIFAEMHGGVGRACAASAIAPTCLRCRRAAAPSLPSLVPLPTVYASATASRLFTTSFLSKLGDSVASKVSQLAENVWLADERLVTESRRKLEPQRVANTTLAERLAAQRNVRQRLVPTCVTIDKSRQYVEFTWPAEAVEVMRTVSLESGAPDAKEPPITLCGESSSVAASATTDGSSSAGSAAPSPATEHAVASIDCAPCGELMRTPSPAPRSLYSPSGMPLRTRALAEYLRAYTPSTDGPFSGKDIVIYGRRGIKITKVIPVGNYALRFVFSDDHNGGIYSYEYLYYLTGPTKYRLMRGYITELRQRRKPRDPPKRAPSTKYAEAITRSAATAPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GRG9</accession>
    <name>A0A836GRG9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RanBP2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_01942</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061018.1">
        <property type="nucleotide sequence ID" value="XM_067203981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GRG9"/>
    <dbReference type="GeneID" id="92357915"/>
    <dbReference type="KEGG" id="loi:92357915"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <source>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5472622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="353" mass="38916" checksum="1898C58447E747BE" modified="2021-09-29" version="1">MNYLRTVVSDVKLKYRASRVVAECVLKREQSEFPKFLTECVTIADGHPELILSTVRLYLAYSQPEKAYSGLLLLEQLVSLCNYAFHLALARDYDIQDRIIHLAMRRGEGEAHQKAQRLARLTLLEYSRVFVDDRDLLRLSALLSSFEHRTHKSLMRCLNVQNRRVRFRDVEKSDIIPISPKECAGYTSTSADRPVKPLQLCSAPEVWPCHVCTYLNAPSATRCAACETLRATDMAVPRSSPHATPKMSPAFSPSDAAANGTGVGEGERERNDPPASSGVNTEDGSENLINDLDDTSNAKLYPYRGPPVATYVGSVHQPRIATNTAVPKDTSHPPVPILPSTDGGPRGGTGKVD</sequence>
</entry>
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        <name type="scientific">Leishmania orientalis</name>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000023">
        <property type="protein sequence ID" value="KAG5478434.1"/>
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    </dbReference>
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        <location>
            <begin position="47"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="357" mass="39327" checksum="3CD6331154A9C0B0" modified="2021-09-29" version="1">MPSYESRHMLRVLDSPQTLAKSFIAYCKRHHVTTRGWCRIGYVRRSPPLNAKAHPDNCLLRGLIANKDIAKDENVVMMPVTACLHPGAAFRCEPFWKLLAPEVQSALSDVACAYNSRIADRSLIRHNQLLLALYMTYLVLLRNCNAAQLSATPGGDAIEYINFMPRNEGNFEQFAAHLAGWLDAPEICRSAQASLASHFQLTQAEVRPVIIYALCMIYSRMVPVDHRACLQFALESTPLARAWDDVEATAAPAALPPPSSAESTGGGCCGSVQSEGVSTSLVRDPISFLCPVIDMCNHSDRENVAVMVPHRDKPSMTGPVICLRTLRPVAKGEELTMTYGAAPHELKLIWGMQDILQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
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        <name evidence="3" type="ORF">LSCM4_00061</name>
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    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Trypanosomatida</taxon>
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            <taxon>Leishmania</taxon>
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    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464621.1"/>
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    </dbReference>
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        <location>
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            <end position="10"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5464621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="296" mass="31462" checksum="371D27CDE3BDD853" modified="2021-09-29" version="1">MGLSDIDEDEPVTHLPRPPVLVAEPPSPRPAIIIGTGGTSAASPMTASSNKNDCSTSVLDDLFGSISISASCGHTGASASPQYHSSSAPATNKAVPAAAATAASSVLNDLFAAPTVASTSHNENHAMLYVDGSSGGVKDDVTDLFDLSKPMKRDKYNNAESFLEAFERQGKKSGSGGDRADDRQTLADLTRNKDDNKVRARLLALMNYYDVLGVSPTASGEEIKRSYKKKALELHPDRVGRDQTQEEAELFKVITKANEVLTDAEQRRKYDASLASGAGQPAMAPSAADWWNHMHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GTD0</accession>
    <name>A0A836GTD0_9TRYP</name>
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            <fullName evidence="3">Thioesterase domain-containing protein</fullName>
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        <name evidence="1" type="ORF">LSCM4_05766</name>
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    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5479759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="23948" checksum="F451CCB01B647D42" modified="2021-09-29" version="1">MTSILKRQALWVPVVKHSPAFVECAQKLLQSSPITSLNAAAMGLKLEEVQVALEPDPRHPDQMMSSMMAFPVQISAPACDFVPDQQSLAQQQQPRELTFGFAISLSDSCNTLHVMERLLPALNPHVSVNIQSHCMRNLREGERLVVVSSIDKMGKRLVYCKTDFYVEAAEPVPEEVVQREKSIKTLAELRAALMYYEKAVSGSHVKSIMSERNPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GTI0</accession>
    <name>A0A836GTI0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription factor IIIC subunit 5 HTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_05842</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063545.1">
        <property type="nucleotide sequence ID" value="XM_067207772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GTI0"/>
    <dbReference type="GeneID" id="92361706"/>
    <dbReference type="KEGG" id="loi:92361706"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001002">
        <property type="term" value="F:RNA polymerase III type 1 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001003">
        <property type="term" value="F:RNA polymerase III type 2 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019136">
        <property type="entry name" value="TF_IIIC_su-5_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040454">
        <property type="entry name" value="TF_IIIC_Tfc1/Sfc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13230:SF5">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13230">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIIC, POLYPEPTIDE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09734">
        <property type="entry name" value="Tau95"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor IIIC subunit 5 HTH" evidence="2">
        <location>
            <begin position="330"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="642"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="665"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="678"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5479834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="701" mass="77047" checksum="D0CE991EE18C48DE" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GTI9</accession>
    <name>A0A836GTI9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Adenylate kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_05857</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the adenylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067207787.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22981">
        <property type="entry name" value="DD_TbAK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Adenylate kinase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036193">
        <property type="entry name" value="ADK_active_lid_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01351">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF57774">
        <property type="entry name" value="Microbial and mitochondrial ADK, insert 'zinc finger' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
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    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007220"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5479849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="36066" checksum="B0B99EEE238C00F5" modified="2021-09-29" version="1">MSAVAGHSMGSKPQQPNSPVAADAMTAAATSEVAASAFDADAASAPFSGTASETSEVKVPVPFMSSNDGLSEDTIKYIKDRNIGQLMEYILRCIITDKPSKPLGYVHDLTASPLPPRLALAGPPASGKGTQAQQICSYYKRTIGKKPVHVSSGDLLRAEVAEGTHLGKIAEACMKCGQLVPDSLIIGIIRNRLTKEDAVVNGWLLDGFPRTRSQAIALDAAGLCPRTFVVLDAPDDILFERVEGRRTDPVTGTIYHLKYNPPPQDDTALLERLQHRDDDTREVLHPRLHAYHSMVEDLLDYYGSIMYRVDANRPQAVITQDITEYLASHDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GUM4</accession>
    <name>A0A836GUM4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA ligase phosphodiesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_00522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058701.1">
        <property type="nucleotide sequence ID" value="XM_067202600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GUM4"/>
    <dbReference type="GeneID" id="92356534"/>
    <dbReference type="KEGG" id="loi:92356534"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032395841" description="tRNA ligase phosphodiesterase domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5465070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="26368" checksum="ED1E38811800477B" modified="2021-09-29" version="1">MSFLALNVCLISSAFDVVALPLSSTLCPVERDDDAEDTSLCYGLAPLTEKGRKGYGYAHCTVMQLCARALDLKAVREIVRETWLKFRTHVLESKESLVLTGLADGPIFATTEDGRTVRLPNITVERSPDLMWLHETIVRELDQYHVKVGSEDVAKSAFHRKFPADSNSITPEWMLSFTSKYAHENYAPHITLGACTEKNVAAFSFLQKTEIPWRECRLVVSHMGNFCSCFDLLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GVE8</accession>
    <name>A0A836GVE8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Abnormal spindle-like microcephaly-associated protein ASH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LSCM4_00307</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
            <location evidence="1">Flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058494.1">
        <property type="nucleotide sequence ID" value="XM_067202393.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836GVE8"/>
    <dbReference type="GeneID" id="92356327"/>
    <dbReference type="KEGG" id="loi:92356327"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052614">
        <property type="entry name" value="CFAP65"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053879">
        <property type="entry name" value="HYDIN_VesB_CFA65-like_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056344">
        <property type="entry name" value="Ig_CFAP65-like_9th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056305">
        <property type="entry name" value="Ig_CFAP65_10th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058536">
        <property type="entry name" value="Ig_CFAP65_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057470">
        <property type="entry name" value="Ig_CFAP65_7th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057467">
        <property type="entry name" value="Ig_CFAP65_8th"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46127">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46127:SF1">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22544">
        <property type="entry name" value="HYDIN_VesB_CFA65-like_Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24291">
        <property type="entry name" value="Ig_CFAP65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24507">
        <property type="entry name" value="Ig_CFAP65_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25249">
        <property type="entry name" value="Ig_CFAP65_7th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25248">
        <property type="entry name" value="Ig_CFAP65_8th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24816">
        <property type="entry name" value="Ig_CFAP65__9th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0282">Flagellum</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HYDIN/VesB/CFA65-like Ig-like" evidence="8">
        <location>
            <begin position="119"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="CFAP65 fourth Ig-like" evidence="10">
        <location>
            <begin position="353"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="CFAP65 seventh Ig-like" evidence="13">
        <location>
            <begin position="859"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="domain" description="CFAP65 eight Ig-like" evidence="12">
        <location>
            <begin position="972"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="domain" description="CFAP65-like ninth Ig-like" evidence="11">
        <location>
            <begin position="1098"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="domain" description="CFAP65 tenth Ig-like" evidence="9">
        <location>
            <begin position="1275"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1525"/>
            <end position="1553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF25248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF25249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG5464863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1713" mass="184149" checksum="3FE355A343C30102" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GVG3</accession>
    <name>A0A836GVG3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">malate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LSCM4_06453</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="3"/>
    <dbReference type="EMBL" id="JAFHLR010000019">
        <property type="protein sequence ID" value="KAG5480884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063885.1">
        <property type="nucleotide sequence ID" value="XM_067208373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GVG3"/>
    <dbReference type="SMR" id="A0A836GVG3"/>
    <dbReference type="GeneID" id="92362307"/>
    <dbReference type="KEGG" id="loi:92362307"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070013">
        <property type="term" value="C:intracellular organelle lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000268">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.110.10:FF:000009">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010097">
        <property type="entry name" value="Malate_DH_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01772">
        <property type="entry name" value="MDH_euk_gproteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540">
        <property type="entry name" value="MALATE AND LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540:SF18">
        <property type="entry name" value="MALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0520">NAD</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="12">
        <location>
            <begin position="3"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="13">
        <location>
            <begin position="157"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="8"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="125"/>
            <end position="127"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG5480884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="322" mass="33788" checksum="B14A10FF83960D5C" modified="2021-09-29" version="1">MVNVCVVGAAGGIGQSLSLLLMRQLPYGSTLSLFDVVGAAGVAADLSHVDNAGVQVKYAAGKVGVQRDPALAELSKGVDVFVVVAGVPRKPGMTRDDLFKINASIILDIVLTCASSSPKAVFCIVTNPVNSTVAIAAEALKSLGVYDKNRLMGVSLLDGVRATRFINEARKPVVVNQVPVIGGHSDTTIVPLFHQLPGPLPEQATLDKIVKRVQVAGTEVVKAKAGRGSATLSMAEAGARFALKVVEGLTGAGNPLMYAYVDTDGQHETPFLAIPVVLGQRGIEKRLPIGDLHPTEQKLLKEAMPVIRKNIAKGCEFARSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GXA4</accession>
    <name>A0A836GXA4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ADP/ATP translocase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ADP,ATP carrier protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">LSCM4_06402</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Catalyzes the exchange of ADP and ATP across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ADP(in) + ATP(out) = ADP(out) + ATP(in)</text>
            <dbReference type="Rhea" id="RHEA:34999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:35000"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 16">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000019">
        <property type="protein sequence ID" value="KAG5480834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063835.1">
        <property type="nucleotide sequence ID" value="XM_067208323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GXA4"/>
    <dbReference type="SMR" id="A0A836GXA4"/>
    <dbReference type="GeneID" id="92362257"/>
    <dbReference type="KEGG" id="loi:92362257"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140021">
        <property type="term" value="P:mitochondrial ADP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990544">
        <property type="term" value="P:mitochondrial ATP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000096">
        <property type="entry name" value="ADP,ATP carrier protein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002113">
        <property type="entry name" value="ADT_euk_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635">
        <property type="entry name" value="ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635:SF14">
        <property type="entry name" value="ADP_ATP TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00927">
        <property type="entry name" value="ADPTRNSLCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="11 14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="28"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="129"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="225"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU368008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG5480834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="320" mass="35572" checksum="5E5B2DB3E81E4736" modified="2021-09-29" version="1">MSANNASAAAAPAPKKARQDMRKLGFWEEFMISGVAAGAAKTAAAPIERVKLLVQNQGEMIKQGTLDRPYSGVMNCLTRTVKTEGLYALWRGNLSNVIRYFPTQALNFAFKDQFKRMFNYKKDRDGYMKWFMGNMASGGLAGAVSLCFVYSLDYVRTRLANDTKSAKKGGERQYNGMVDCYIKTFKSDGLMGLYRGFCVSCVGIVAYRGFYFGLYDTLQPMLPVNNFIVNFMLGWVVTIVSGLISYPLDTVRRRMMMTSGTGKNYRNSFECFTQCVKNEGMASLFRGAGANILRGVAGALVLSGVDAIKPYYIMVRAKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GZR3</accession>
    <name>A0A836GZR3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyltransferase B complex (NatB) non catalytic subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MDM20/NAA25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061049.1">
        <property type="nucleotide sequence ID" value="XM_067204012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GZR3"/>
    <dbReference type="SMR" id="A0A836GZR3"/>
    <dbReference type="GeneID" id="92357946"/>
    <dbReference type="KEGG" id="loi:92357946"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031416">
        <property type="term" value="C:NatB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019183">
        <property type="entry name" value="NAA25_NatB_aux_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767:SF3">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 25, NATB AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09797">
        <property type="entry name" value="NatB_MDM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5472653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="899" mass="99374" checksum="D6AB8149BA17DEF6" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H2I8</accession>
    <name>A0A836H2I8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial RNA binding complex 1 subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060157.1">
        <property type="nucleotide sequence ID" value="XM_067204605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H2I8"/>
    <dbReference type="SMR" id="A0A836H2I8"/>
    <dbReference type="GeneID" id="92358539"/>
    <dbReference type="KEGG" id="loi:92358539"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="349"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="434"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5469180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="747" mass="82990" checksum="A71F37C095FBE9DF" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H486</accession>
    <name>A0A836H486_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1935 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_04533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062726.1">
        <property type="nucleotide sequence ID" value="XM_067206517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H486"/>
    <dbReference type="SMR" id="A0A836H486"/>
    <dbReference type="GeneID" id="92360451"/>
    <dbReference type="KEGG" id="loi:92360451"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015232">
        <property type="entry name" value="DUF1935"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036310">
        <property type="entry name" value="Smp-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47047:SF4">
        <property type="entry name" value="CYSTEINE PEPTIDASE, PUTATIVE CYSTEINE PEPTIDASE, CLAN CA, FAMILY C2, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47047">
        <property type="entry name" value="PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09149">
        <property type="entry name" value="DUF1935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101601">
        <property type="entry name" value="Smp-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1935" evidence="1">
        <location>
            <begin position="16"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5477315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="142" mass="16716" checksum="CD20DCDDE65B05FD" modified="2021-09-29" version="1">MGCGYSTYSAQDDIVWKYGGPSEEPLKALKMFPKHQNGLLFRLLYDDGERWAFYNDTLEYEFHIRYYFSRDSDIEALRNATLSELENGNKLVEIIVYPKETQDFIVGVAGSYTSTIEAIPVTERFQWEKSKEKYEQKRGRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H6E6</accession>
    <name>A0A836H6E6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATPase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_08111</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">LSCM4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AFG1 ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000005">
        <property type="protein sequence ID" value="KAG5487666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065954.1">
        <property type="nucleotide sequence ID" value="XM_067209987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H6E6"/>
    <dbReference type="GeneID" id="92363921"/>
    <dbReference type="KEGG" id="loi:92363921"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005654">
        <property type="entry name" value="ATPase_AFG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040713">
        <property type="entry name" value="ZapE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169:SF6">
        <property type="entry name" value="AFG1-LIKE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169">
        <property type="entry name" value="ATPASE N2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03969">
        <property type="entry name" value="AFG1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5487666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="478" mass="55539" checksum="BF7E97C0259C6E16" modified="2021-09-29" version="1">MFRRASLLLSLRPSEAYRQLVLRGDISNDQHQVSALPAFDRLYDDLVRYTENSKRIAVPKRQVELRPPNRLGIIPSFFLRREQEKKVEQALSDDDNAVYHPLSQVKGLYVWGGVGCGKTMLMDLLYDNAPPEIRKRRLHFHQFMLDMQKTSQSIRYKSKEEMQDPANRRNMVRYNTSDDLRRTPDAEINLFDEVAQRMISDVELLCFDEVAVSDVAHAMILKRLFHSFYKIGLVVIFTSNRPIDDLYKDGLNRGGFIPFIDLVKRQCTIHHMNSNIDHRLLGHQADTYLTPMNSENNAKFEKLFLEMCKAMPATERRLEVFGRDVIVPRACGGVCYFHFFELCGGEKSAADYEVIARTFHTVFINGVPQFPYENSDVKNRFLLLIDTLYERRCKVMIHAAVEPLQLQAPQKEATGKIEGDTQRFDQLSEFERESGKKLMDADDSAFQMDRCVSRLFEMRTKEYLEVPHEPQDVDLSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H822</accession>
    <name>A0A836H822_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000022">
        <property type="protein sequence ID" value="KAG5479295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063388.1">
        <property type="nucleotide sequence ID" value="XM_067203929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H822"/>
    <dbReference type="GeneID" id="92357863"/>
    <dbReference type="KEGG" id="loi:92357863"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37561">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37561:SF3">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5479295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="506" mass="55399" checksum="457EC482B7AAB00C" modified="2021-09-29" version="1">MPQKTKKTSATVLEDSLGKGVSGGSPCRNAEASPTVVARGCVPAQRSSKRMLNREISLLMLILAAQTITGMVNIQDSVLSTELVADSHSFRGRPSLKSESYSSSYYSSASSDKHVPFMDMSEGISSSTGGSDVSENFDDDGDEEDIVEARFASQLTAPHRANIYFTHNEDIWENIFSFLPWNAALQVRGVSRFHFRESLPRVTIARMPQSKMPAIFIPCLEDLDSDEMEIESELAPQHQTQWSCPHCCLFNAQGSVCSNSRCQQPRPQNGQRLFLGQLRRTGTVPMVRWLVNNVFNASTGALVSVENRRNTHTQRGKGCAWPTISDEATVKRMLDAHHRLFFDSVGGVEGVWLVPAGCERALQSEVSMRYNGGVHQKHMPRGTIVVETPSTSFFVAAPGAAPSNSAKGKEVDGAEEIHGDTKGNATGLPYPAATQSSRSDLSYHSTSTPLPPYPSNQEIDPATRDTADEYYGFHCLASFMPYRVPGVDFVGPGAYRLNPYTALMQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H9F8</accession>
    <name>A0A836H9F8_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_03555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061489.1">
        <property type="nucleotide sequence ID" value="XM_067205552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H9F8"/>
    <dbReference type="SMR" id="A0A836H9F8"/>
    <dbReference type="GeneID" id="92359486"/>
    <dbReference type="KEGG" id="loi:92359486"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="206"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="320"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="19"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="335"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5473486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="723" mass="78817" checksum="4321F4E280630A8D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HA50</accession>
    <name>A0A836HA50_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_05628</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May contribute to the rapid motility of the trypanosomes, playing a role either in flagellar structure or in calcium metabolism. Could alternate between a GDP-bound inactive form to a calcium/GTP-bound active form.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Cilium</location>
            <location evidence="2">Flagellum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the calflagin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000016">
        <property type="protein sequence ID" value="KAG5482372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064378.1">
        <property type="nucleotide sequence ID" value="XM_067207564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HA50"/>
    <dbReference type="GeneID" id="92361498"/>
    <dbReference type="KEGG" id="loi:92361498"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051581">
        <property type="entry name" value="Ca-bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003299">
        <property type="entry name" value="Calflagin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054322">
        <property type="entry name" value="FCABP_EF-hand"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34524">
        <property type="entry name" value="CALCYPHOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22592">
        <property type="entry name" value="FCaBP_EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01362">
        <property type="entry name" value="CALFLAGIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0282">Flagellum</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="11">
        <location>
            <begin position="33"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="11">
        <location>
            <begin position="116"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="11">
        <location>
            <begin position="153"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5482372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="194" mass="21760" checksum="D79604E90F8D00D1" modified="2021-09-29" version="1">MQNQGKGGEKAAADRKAAWENVQLRLPRQKTSEDEEGRSELFKKFDQNGAGKLTMEEFYQGCVDILQLDEFTTRLRDIVKRAFNKAKSMVNTAGDGQGSAEFVEHCEFRLMLCYIYHYFALTVMFDEIDTSGNMVVDEKEFKAALPKIGSWGLVIEDPEAAFKEIDDNGSGQVTFDEFAAWASAQKLGNEADVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HAM1</accession>
    <name>A0A836HAM1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Leucine-rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_07580</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000004">
        <property type="protein sequence ID" value="KAG5487899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066096.1">
        <property type="nucleotide sequence ID" value="XM_067209464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HAM1"/>
    <dbReference type="SMR" id="A0A836HAM1"/>
    <dbReference type="GeneID" id="92363398"/>
    <dbReference type="KEGG" id="loi:92363398"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052311">
        <property type="entry name" value="MMS22L-TONSL_complex_comp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46358">
        <property type="entry name" value="TONSOKU-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46358:SF1">
        <property type="entry name" value="TONSOKU-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5487899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="187" mass="20561" checksum="681D30B9CF0E57EF" modified="2021-09-29" version="1">MPPKHTPKPPGGKRVRKPATNHAKVRAPSLQEVYIRSCAEMGLRPNSAFTSLLPDQSGVDYPAAALDLSRNYVGDRGIAPILATLEKMPNLRALILSENGLRNRGVELVCASAVNLPHLEFLELSDNFISEGAAAALFRLIEHHHQLQMVAFENTKIPVEWRVKLLDALAEKRSTTQTLARASILVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HB65</accession>
    <name>A0A836HB65_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_08179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000002">
        <property type="protein sequence ID" value="KAG5488199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066247.1">
        <property type="nucleotide sequence ID" value="XM_067210049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HB65"/>
    <dbReference type="SMR" id="A0A836HB65"/>
    <dbReference type="GeneID" id="92363983"/>
    <dbReference type="KEGG" id="loi:92363983"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="565"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="681"/>
            <end position="711"/>
        </location>
    </feature>
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        </location>
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    </feature>
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        <location>
            <begin position="683"/>
            <end position="693"/>
        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="872" mass="87927" checksum="C0EA81D5F0CD8B49" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </comment>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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        </source>
    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
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    <sequence length="192" mass="21335" checksum="E77CB7748DAEBD4D" modified="2021-09-29" version="1">MSGSFALRKLLFDAGDQEEVNRRGYHYAGAYAPLLHPVAVLQPAAVLPKSGLPFACLCLLTSFSTCLTMKVRYNERWWMGMFAICVVYYSSVKAHKVDNGLVGHQSGFFAAGMGVIGCVARLMARSGSPRKNLGALGLFSGLLWYETGRYHLWTEHVTEFRRGVTPERSCDLLGEYVPQSLEAAFLPYRSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5474656.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="554" mass="59965" checksum="F19E2882DA177A96" modified="2021-09-29" version="1"> </sequence>
</entry>
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        </submittedName>
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                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <evidence type="ECO:0000256" key="1">
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="466" mass="51248" checksum="BD9238A2782F32CD" modified="2021-09-29" version="1">MKSLASLPLAALLFLLTLSAVVEVAQAQGLPGLLALQIKGYVSYSSAYLSTSGVEVTYDSTEKMCFDAGGVPASDTNAELSVAVAHEMRVNGGTRTSTIYTGASAEPSLPDTKCKERTTGTEAPNSANCYYRWRYGFYDMYSYNGEPGTAYWANLYMTNSAASQVLNQFEQFIWNPAPSPAGDKYPRGYYGAIASLDAAGTGLYRMDAPLTPNENDPNPKSQFMIVCEYQLYPERPPFTTRLPQPQFVNGFKSLTWSQSNWWVIFMVFAIIILAFLTAIVLYCYCTSTRPKEEPPLFQMVIRERFGKAYIISDGPPMAAKQPCAAPGSMPPPTLSPEKEEHRRQLRCGRSFNPQQRTDEEDMSVGMAGIFDNGERRMYAAGSVIENAGEKPVDSNFEDIGEDAFPYSRQPSGSQGADGSGSTCQEPSLVTSKRRSVRRSRNHTTSRAFSDVDIPQAGEIDETNVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062018.1">
        <property type="nucleotide sequence ID" value="XM_067206081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HER0"/>
    <dbReference type="GeneID" id="92360015"/>
    <dbReference type="KEGG" id="loi:92360015"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5475510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="469" mass="51002" checksum="84F6789EE76EB1CB" modified="2021-09-29" version="1">MLDQWKLDAESEDHRSRRDMTEKSITRYVKGEVERQVTSSSTSSSVFVTDCTWIMGASVAQPSYLCCGLSNGSVCLLNTANLSKIYLFEADRNFRTSLRDSDRGGQVQGRERVSSVSQQLVAVATHTVPAGTDSAAVQALLCLTLDSVVCVCPMDMLAVLERKKVSRSDLAKVKPYPAVAVDAVLHSSVQFNSKGNSILALLCIKEESSVASGASSIRYCVAVLSSPDATVTLQSKYACDRGWHTLAYPCAGGESRFGAPVELCYCGWWTADTLVCVWSNSALQFLHAAEMQVIAEGRLLRHCASDRVTNATVTRPGAGDASDGASGGLVAVVLEHNIAASFYVTVRHSAGYDEELKRHCGEAPFAVSMIPTMQTYCTEDIPVRELHLVRSFSWTVVLLLESGALVFLDAETMRLSVHRAVNRLRPPDTDRYHAGPLIIAPRHFFCVLTGKPFSVVVVEYSTAILLKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HFC9</accession>
    <name>A0A836HFC9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">H/ACA ribonucleoprotein complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Nucleolar protein family A member 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_07322</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Common component of the spliceosome and rRNA processing machinery.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000015">
        <property type="protein sequence ID" value="KAG5483105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064601.1">
        <property type="nucleotide sequence ID" value="XM_067209218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HFC9"/>
    <dbReference type="SMR" id="A0A836HFC9"/>
    <dbReference type="GeneID" id="92363152"/>
    <dbReference type="KEGG" id="loi:92363152"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000002">
        <property type="entry name" value="NHP2-like protein 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002415">
        <property type="entry name" value="H/ACA_rnp_Nhp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00883">
        <property type="entry name" value="NUCLEARHMG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="10">
        <location>
            <begin position="21"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5483105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="126" mass="13546" checksum="55579DCC7AA1901E" modified="2021-09-29" version="1">MTGEISEKAFPLATDRLSQTILDLVQEASNAKMVKKGANEATKALNRGIADLIVLAGDTNPIEILLHLPLLCEDKNVPYVFVPSKTALGRASQVSRNVVALSILQGENSPVATKVQAVKLEIERLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HHN7</accession>
    <name>A0A836HHN7_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_07886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000013">
        <property type="protein sequence ID" value="KAG5484320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064813.1">
        <property type="nucleotide sequence ID" value="XM_067209763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HHN7"/>
    <dbReference type="GeneID" id="92363697"/>
    <dbReference type="KEGG" id="loi:92363697"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5484320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="198" mass="21858" checksum="B1440B37493BD6D1" modified="2021-09-29" version="1">MQGPGDANTSASPAPVLNNRPTGRSISYEEIYKAAKCSVLTDFYREKRYRDLRRRIADSGENVQLIPVATGGDADSPKLVRASTSRLLKEHGSASWSASFYQSGVYGLTGVSSICTAIALYIGIYHNRLVLPVVPMGAAVTWRLWGVLEDIWNEQRYIDNAAKIREERQGNPMNAVVKRRRKLDSVAKLGSPAAELME</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HIF4</accession>
    <name>A0A836HIF4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_04516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062709.1">
        <property type="nucleotide sequence ID" value="XM_067206500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HIF4"/>
    <dbReference type="GeneID" id="92360434"/>
    <dbReference type="KEGG" id="loi:92360434"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="CDD" id="cd00027">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="542"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="611"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5477298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1254" mass="131841" checksum="7FDC552D11B7AB60" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HII7</accession>
    <name>A0A836HII7_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_04774</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RICTOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000023">
        <property type="protein sequence ID" value="KAG5478541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063202.1">
        <property type="nucleotide sequence ID" value="XM_067206755.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836HII7"/>
    <dbReference type="GeneID" id="92360689"/>
    <dbReference type="KEGG" id="loi:92360689"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028268">
        <property type="entry name" value="Pianissimo_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028267">
        <property type="entry name" value="Pianissimo_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029453">
        <property type="entry name" value="Rictor_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029451">
        <property type="entry name" value="RICTOR_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029452">
        <property type="entry name" value="RICTOR_V"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13298">
        <property type="entry name" value="CYTOSOLIC REGULATOR PIANISSIMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13298:SF11">
        <property type="entry name" value="RAPAMYCIN-INSENSITIVE COMPANION OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14663">
        <property type="entry name" value="RasGEF_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14666">
        <property type="entry name" value="RICTOR_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14664">
        <property type="entry name" value="RICTOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01303">
        <property type="entry name" value="RasGEF_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01307">
        <property type="entry name" value="RICTOR_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01308">
        <property type="entry name" value="RICTOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01310">
        <property type="entry name" value="RICTOR_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rapamycin-insensitive companion of mTOR N-terminal" evidence="4">
        <location>
            <begin position="168"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="Rapamycin-insensitive companion of mTOR middle" evidence="3">
        <location>
            <begin position="664"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="domain" description="Rapamycin-insensitive companion of mTOR" evidence="5">
        <location>
            <begin position="1310"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1129"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1161"/>
            <end position="1172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5478541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1530" mass="166102" checksum="7148B8857113653B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HIJ8</accession>
    <name>A0A836HIJ8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA polymerase theta (Helicase domain only)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LSCM4_04789</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000023">
        <property type="protein sequence ID" value="KAG5478556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063217.1">
        <property type="nucleotide sequence ID" value="XM_067206770.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836HIJ8"/>
    <dbReference type="GeneID" id="92360704"/>
    <dbReference type="KEGG" id="loi:92360704"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18026">
        <property type="entry name" value="DEXHc_POLQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.20:FF:000004">
        <property type="entry name" value="DNA polymerase theta (Helicase domain only), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000813">
        <property type="entry name" value="helicase POLQ-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046931">
        <property type="entry name" value="HTH_61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048960">
        <property type="entry name" value="POLQ-like_helical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF6">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20470">
        <property type="entry name" value="HTH_61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21099">
        <property type="entry name" value="POLQ_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="1236"/>
            <end position="1460"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="1491"/>
            <end position="1732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="156"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="332"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="462"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="778"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1066"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1388"/>
            <end position="1410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1801"/>
            <end position="1842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="784"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="798"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1066"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1828"/>
            <end position="1842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG5478556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2245" mass="233729" checksum="82C1A832BA1B2E75" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HJ63</accession>
    <name>A0A836HJ63_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peroxisomal ATPase PEX6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Peroxin-6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_05536</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000016">
        <property type="protein sequence ID" value="KAG5482283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064289.1">
        <property type="nucleotide sequence ID" value="XM_067207475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HJ63"/>
    <dbReference type="SMR" id="A0A836HJ63"/>
    <dbReference type="GeneID" id="92361409"/>
    <dbReference type="KEGG" id="loi:92361409"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000109">
        <property type="entry name" value="Peroxisomal biogenesis factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF9">
        <property type="entry name" value="PEROXISOMAL ATPASE PEX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="680"/>
            <end position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5482283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="959" mass="103385" checksum="E45492C41BC6D14D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HJP3</accession>
    <name>A0A836HJP3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_05305</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5477913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062820.1">
        <property type="nucleotide sequence ID" value="XM_067207252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HJP3"/>
    <dbReference type="SMR" id="A0A836HJP3"/>
    <dbReference type="GeneID" id="92361186"/>
    <dbReference type="KEGG" id="loi:92361186"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="4">
        <location>
            <begin position="96"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="196"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5477913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="543" mass="58333" checksum="AD4E1A5B72A2D136" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HKM1</accession>
    <name>A0A836HKM1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial carrier protein-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_04788</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000023">
        <property type="protein sequence ID" value="KAG5478555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063216.1">
        <property type="nucleotide sequence ID" value="XM_067206769.1"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A836HKM1"/>
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    <dbReference type="KEGG" id="loi:92360703"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="Mitochondrial carrier domain"/>
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    </dbReference>
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        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
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    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="48"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
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            <begin position="173"/>
            <end position="255"/>
        </location>
    </feature>
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        <location>
            <begin position="292"/>
            <end position="374"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
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        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5478555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="390" mass="42165" checksum="DEDD3FB768EFB1B3" modified="2021-09-29" version="1">MWGGRSGGTSATAPPTAAVARHDAELKPPEKAGTGGCRDGYKADTQYASPEITALASSVATIVTKSTLHPLDTLKCRIQLLRTDVAPALQDGQRFQCNASRCLPALLRTRLEQLRHQYAAQWTLGHLYGGLPVKLLFYVPYQATYVSSYNFAQRTLCGADGAGEGAAGPLTANYVWHTVAAAVFAEAASAVIRVPMETVKMRIQSAAASGSLHALRQLWRQGFASCLRLAVPQTLMHDIPYSVIQWVVYETLRPWTQQWGTRVGKQVRSTGPGEASSAPTSFWADYGAELARTFLSGGFSGLLASALTAPLDNIRTRVVVATARDRNLTISDVVRDAYQREGMRGFVRGGGMRVLWVTTNMALYFPLFEGVRSLLQRRGHGSSSAGASLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HKR9</accession>
    <name>A0A836HKR9_9TRYP</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000003">
        <property type="protein sequence ID" value="KAG5488042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066169.1">
        <property type="nucleotide sequence ID" value="XM_067210136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HKR9"/>
    <dbReference type="GeneID" id="92364070"/>
    <dbReference type="KEGG" id="loi:92364070"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5488042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="564" mass="59614" checksum="F0B93D520E16DD5A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HP60</accession>
    <name>A0A836HP60_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000020">
        <property type="protein sequence ID" value="KAG5480385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_067208076.1"/>
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    <dbReference type="GeneID" id="92362010"/>
    <dbReference type="KEGG" id="loi:92362010"/>
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        <property type="component" value="Chromosome 20"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13391">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION REGULATOR MISATO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13391:SF0">
        <property type="entry name" value="PROTEIN MISATO HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5480385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="707" mass="76372" checksum="60207F61D15E8A91" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HPD0</accession>
    <name>A0A836HPD0_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_07571</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000004">
        <property type="protein sequence ID" value="KAG5487890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066087.1">
        <property type="nucleotide sequence ID" value="XM_067209455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HPD0"/>
    <dbReference type="SMR" id="A0A836HPD0"/>
    <dbReference type="GeneID" id="92363389"/>
    <dbReference type="KEGG" id="loi:92363389"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="126"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="422"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="561"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="656"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="704"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="244"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="351"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
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            <dbReference type="SAM" id="Coils"/>
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        <source>
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        </source>
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        <source>
            <dbReference type="EMBL" id="KAG5487890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="739" mass="80140" checksum="543B9DAA279FCFF2" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <begin position="80"/>
            <end position="104"/>
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        <location>
            <begin position="137"/>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="173" mass="18939" checksum="A07FD0988797C4DD" modified="2021-09-29" version="1">MPILLAPPLKLTPPLATTYTDGRRTSGIGLRFPFCAASTAYLLAVVDVRASNSESSKATGPTYSHGVGLRDLHPIDRKRCFTCCIIMFWSHPVSLACLSVVIMAPLMCAQAVAAQGSDITVAQAQQKMPESEKNEHVLRLVLIVLPVMFVIWLILGGIFTFIFIRVCPNMYTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="4">V-SNARE coiled-coil homology domain-containing protein</fullName>
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    <reference evidence="5 6" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
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                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HRX8</accession>
    <name>A0A836HRX8_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">LSCM4_06901</name>
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            <taxon>Leishmania</taxon>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000017">
        <property type="protein sequence ID" value="KAG5481825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064185.1">
        <property type="nucleotide sequence ID" value="XM_067208811.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="92362745"/>
    <dbReference type="KEGG" id="loi:92362745"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="312"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="646"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1087"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="861"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1006"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="362"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="403"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="446"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="490"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="552"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="572"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="676"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5481825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1205" mass="131539" checksum="23EDAA1B2BB43292" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HUQ5</accession>
    <name>A0A836HUQ5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome c oxidase assembly protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_08207</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000003">
        <property type="protein sequence ID" value="KAG5487983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066110.1">
        <property type="nucleotide sequence ID" value="XM_067210077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HUQ5"/>
    <dbReference type="SMR" id="A0A836HUQ5"/>
    <dbReference type="GeneID" id="92364011"/>
    <dbReference type="KEGG" id="loi:92364011"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.370.10:FF:000001">
        <property type="entry name" value="COX11 cytochrome c oxidase assembly homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.370.10">
        <property type="entry name" value="Ctag/Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023471">
        <property type="entry name" value="CtaG/Cox11_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007533">
        <property type="entry name" value="Cyt_c_oxidase_assmbl_CtaG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21320:SF3">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21320">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04442">
        <property type="entry name" value="CtaG_Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110111">
        <property type="entry name" value="Ctag/Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5487983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="28805" checksum="14D374C73C470809" modified="2021-09-29" version="1">MFRVCRLRYCAAGAAAGGSGGGTPPPHQCAGDFSASEKQLKSSGRRRYRIESGYDGAKNYDERGQFFSAFLSLGIISLGCTFLFVPLYRMYCAPTGRGADPKFYTPEAARERDEQNKHYPVPKKLLKVRFLSDVGNTMPIAFVPLQREVEVLVGEPALAFYSAYNRSNRTLLGVSSYTIAPPEVTNYLNKIQCFCFEEQRFKPHELVEMPVFFYIDRDFLNDPMVNWLDEVIVNYTFFNLEKTKDHIFRSSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HXH7</accession>
    <name>A0A836HXH7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000009">
        <property type="protein sequence ID" value="KAG5486131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065462.1">
        <property type="nucleotide sequence ID" value="XM_067208751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HXH7"/>
    <dbReference type="SMR" id="A0A836HXH7"/>
    <dbReference type="GeneID" id="92362685"/>
    <dbReference type="KEGG" id="loi:92362685"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE RDL2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086:SF10">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE_RHODANESE-LIKE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="30"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5486131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="150" mass="16257" checksum="7AFBF9F2F4203F3F" modified="2021-09-29" version="1">MLGRTWCARRYVSIDQVANIVKAKQSCCDAARNIQLIDVRSTAEVAATGIIPFAINIPLPILRDVLSPESILKDDEFEFFFGGSRPVQGVTQIVLYCAHGVRSSVACELAEELGFENAGNFSGSWAQWYSAYGPSSTSAAPPESSQTPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KB66</accession>
    <name>A0A836KB66_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_02704</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060280.1">
        <property type="nucleotide sequence ID" value="XM_067204728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KB66"/>
    <dbReference type="SMR" id="A0A836KB66"/>
    <dbReference type="GeneID" id="92358662"/>
    <dbReference type="KEGG" id="loi:92358662"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000067">
        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000004">
        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_uS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_uS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005711">
        <property type="entry name" value="Ribosomal_uS5_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_uS5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_uS5_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01020">
        <property type="entry name" value="uS5_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718:SF4">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="RIBOSOMAL S SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S5 DRBM" evidence="9">
        <location>
            <begin position="87"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5470014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="264" mass="28630" checksum="2282D77BD9BAF608" modified="2021-09-29" version="1">MAETQPAENPIVEAPRAERGFGRGRGGRGGRGRGRGGPGEEKEWVPCTKLGRLVKAQKVTSLEEIFLFSMPIKEHQIVDTLIGEGRLRDEMMKIYPVQKATSAGQRTRFKAFNVVGDGDGHIGIGARVGKEVSLAIRASMIAAKLNIVPVRRGYWGNKIGEPHTIPMKVTGKCGSVAVRLVPAPRGTGIVAAPVPKKILEFAGVEDVYTSSRGKTRTHGNLIMATFYALRKTYGFLTPDLWADTEPSRDPTDEHAELLAEMTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KCS3</accession>
    <name>A0A836KCS3_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060706.1">
        <property type="nucleotide sequence ID" value="XM_067205154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KCS3"/>
    <dbReference type="GeneID" id="92359088"/>
    <dbReference type="KEGG" id="loi:92359088"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="608"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="652"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="273"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="665"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5471589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="679" mass="70397" checksum="96577A6FE1345F23" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KD13</accession>
    <name>A0A836KD13_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059719.1">
        <property type="nucleotide sequence ID" value="XM_067203069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KD13"/>
    <dbReference type="GeneID" id="92357003"/>
    <dbReference type="KEGG" id="loi:92357003"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5467917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="279" mass="28919" checksum="ADE8CCD9BC0D390C" modified="2021-09-29" version="1">MSRVASATCPLLDCTLAIDNAENIRNSKDAALSGLKAAVATAAVRSTPRQRALLRNVKATNRSAAAAETVAPSERRERISGATHRTNVAPATAVVNAAAAVPLSSTGVAFSSSLVGSYIFTKPPTLHRNDPYAPCLLESACTPEESFYACYCEVNEAPAVLAATPTSTPIRSHVVSQPAALPAQTQALLELLSKATVSFSHSLSPMMTPIKGFDSVDQSPASLAAGGGLTTTPSLASTPERFASPPSRQPPTASARVIRKVVCCGVDRTSGRPVPKPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KF47</accession>
    <name>A0A836KF47_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LSCM4_03233</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">LSCM4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060798.1">
        <property type="nucleotide sequence ID" value="XM_067205246.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92359180"/>
    <dbReference type="KEGG" id="loi:92359180"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000013">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000082">
        <property type="entry name" value="ABC transporter, multidrug resistance associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000630">
        <property type="entry name" value="ATP-binding cassette (ABC) transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF273">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="515"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="545"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1189"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1258"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1287"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1374"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="295"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="707"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="1155"/>
            <end position="1435"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1518"/>
            <end position="1777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="673"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1037"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1099"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1037"/>
            <end position="1048"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG5471681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1834" mass="195921" checksum="70E0DFBBE3FA6A5D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KFN2</accession>
    <name>A0A836KFN2_9TRYP</name>
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        <recommendedName>
            <fullName evidence="4">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060017.1">
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000674143">
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            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="239"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5469040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="364" mass="41470" checksum="F0F1169527F087AB" modified="2021-09-29" version="1">MTDPTRRDPTEFLRVLRRMSNTTSWQKAMIFASKGRMVGYRLTLEHYNTILYSQSMWGRALEMIKVIRAMQQDGVQPNGATYYYIVNGMANAEHGYNYDFNINHRLEKLQHWRVALNALQACEANGFDSTDTMHNSVIVTMTIPGMNHWREALRMLKKIVDEDRQLHPNMVRFLHDCLIRNYRPREASDLCRLAAERGVKGYEGAWETDVYKGKPTDAQLEAAQAQEVVKSLGDVDCVPGSSSASPSSASGGKEDARNPAPASAAATLMALQLRGDQALPPPQVLAALQEEMERNITAERQALRPFTAGLHYTEMQSVFRPRVHRQLWYQWHQIANRYRPTTALKRRQLAPRDSPTGIPAWNRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KFV6</accession>
    <name>A0A836KFV6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Oxidoreductase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03838</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061770.1">
        <property type="nucleotide sequence ID" value="XM_067205833.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="92359767"/>
    <dbReference type="KEGG" id="loi:92359767"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:001229">
        <property type="entry name" value="Oxidoreductase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF2">
        <property type="entry name" value="OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="adh_short"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="249"/>
            <end position="276"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="744"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5474664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="964" mass="107448" checksum="1DD6903E8C995A44" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KG01</accession>
    <name>A0A836KG01_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
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            <taxon>Trypanosomatida</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067204030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KG01"/>
    <dbReference type="GeneID" id="92357964"/>
    <dbReference type="KEGG" id="loi:92357964"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5472671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="317" mass="35989" checksum="7BB743A821006AB2" modified="2021-09-29" version="1">MIVCFYAIGRHPLHIRRSYLLSLEHFTHQLSNHSQKHVFSMRRIVSSPCFRILRHVVVGPSTTIPSASSTPQFGRRRQRRQKGLSSPSFDVENDQDAKNICFERYGFVQKPMFLETWQEFLRELQRVELGWSLAPSAGGTLQLKIHDHFEPGDGLLCELKGAANRSAPLAEFFEACGSVSQGAVSKCEIRFFDGESCSVLLIEGKKRLGESTFKDEPPILPLLCQFDCRGISVSLSVLDEKTLVRTPLFSDVSIQALNYAFLTSLPLFLKRTDLGIRNADFVTKDQMRHFRYAWCFLRKESCMTPVELGELDALLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KGF7</accession>
    <name>A0A836KGF7_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060949.1">
        <property type="nucleotide sequence ID" value="XM_067205397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KGF7"/>
    <dbReference type="GeneID" id="92359331"/>
    <dbReference type="KEGG" id="loi:92359331"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5471832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="267" mass="29210" checksum="DF227ECEBA27ACBC" modified="2021-09-29" version="1">MGRHSDSEDRGSRGCYELLASWFPGLRRPTQRRASRDESTSLSCSSSSTNSKSAASDATDEDDESQSFDELGSLPSQSWNSAGDVVSTDSAESDGPSEESDPQERARRAAASFLQWKNKEYVPLSGDEKRAIKEYRRAVAQEEGSYMSTRAQRPLDGAPRRLTPRTDECDLVGPADGCVLMRRRSSKIRFIAAVVASRAVNVHNDALVVTGAGEEVPALPRSASILRSSSMTRPTEEPPVFLEDSEKCMPEGEEKFGEAALCPVFHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KH00</accession>
    <name>A0A836KH00_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_04313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062237.1">
        <property type="nucleotide sequence ID" value="XM_067206300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KH00"/>
    <dbReference type="GeneID" id="92360234"/>
    <dbReference type="KEGG" id="loi:92360234"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5475729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="247" mass="27411" checksum="78E6CB78657D7763" modified="2021-09-29" version="1">MDQGAVSEWNVVGTFRKRPVPQGPIVDFTSDVSHRDSLENTDAPILLYEVKGDGNQQQSRVPRYMARKIAIPPPSLVKMKVVSLAPPRPADPGTHSDEDLFFVDCPEPPSAPSHHKDRVHRQQSLVIGTILPPPSQSTFLLPFAVCLADIALLAVSFTTYKPEKAIIAACCVLVLVPDIGALFLLLKRGMYSVTIAVHLLLWPNVVLLFLQPFVSLLFMVHFLLVALMVLCCLRVRASTYMTFCRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KHQ9</accession>
    <name>A0A836KHQ9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Homologous recombination OB-fold protein OB-fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_03809</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061742.1">
        <property type="nucleotide sequence ID" value="XM_067205805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KHQ9"/>
    <dbReference type="GeneID" id="92359739"/>
    <dbReference type="KEGG" id="loi:92359739"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058570">
        <property type="entry name" value="HROB_OB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15072">
        <property type="entry name" value="HROB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homologous recombination OB-fold protein OB-fold" evidence="2">
        <location>
            <begin position="33"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5474636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="248" mass="26847" checksum="BAB20846DAD3C215" modified="2021-09-29" version="1">MDPQKVLESLAREKGIALTHLSEISSKYSQSAKVACCGGLMMRLVTESAADSTVLLRDGSGSCYCALHGDITNRYPDVLTTGALLLFTDITVLVVSSKVPPMLIACLQNLTGLLLPDKAASAAASTTSRSTRPTGRRSEPARTVYANDAAPYKDDLARAEMWQPDLLTNERREYGDMNPINGSDSARDSFMEPHVSARAIVLAHPARDERRDSAPAEKRIRTENPTASAALEVDYEDDAECLELVDGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KI99</accession>
    <name>A0A836KI99_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Acetyl-CoA C-acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_03262</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">LSCM4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060827.1">
        <property type="nucleotide sequence ID" value="XM_067205275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KI99"/>
    <dbReference type="GeneID" id="92359209"/>
    <dbReference type="KEGG" id="loi:92359209"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050521">
        <property type="entry name" value="3-ketoacyl-CoA_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42689">
        <property type="entry name" value="ACETYL-COA ACYLTRANSFERASE FADA2 (3-KETOACYL-COA THIOLASE) (BETA-KETOTHIOLASE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42689:SF1">
        <property type="entry name" value="ACETYL-COA ACYLTRANSFERASE FADA2 (3-KETOACYL-COA THIOLASE) (BETA-KETOTHIOLASE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="6">
        <location>
            <begin position="120"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5471710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="261" mass="27936" checksum="B46EC61EED662E30" modified="2021-09-29" version="1">MGWHGDVIGELNSISREDQEALAVASHANAARAEKAGYFSDEIVPVMVDATKNIEVKCDDVLQRDTEKMKAKMPSLKPVFRKDKGTITAATSSALTDGGSAMLVMSEEKAKKLGYPTDVSVKSWYFCGIDPYPQLLLAPVLGWGPALRKAGLAPKDIDLYEIHEAFAAQVLATIKCLRSQEFFDRYAGGGKPLLTEDIDRSRLNVNGGSLALGHPFAATGGRIVTSLANELRRSGKRHGLVSICAAGGLGGVAVLEHTPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KJE2</accession>
    <name>A0A836KJE2_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_00944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059660.1">
        <property type="nucleotide sequence ID" value="XM_067203010.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92356944"/>
    <dbReference type="KEGG" id="loi:92356944"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37743">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37743:SF1">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="822"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1194"/>
            <end position="1216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5467858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1543" mass="165122" checksum="52B8962917F77743" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KK97</accession>
    <name>A0A836KK97_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein pelota homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_05003</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway. In the Pelota-HBS1L complex, pelo recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the eukaryotic release factor 1 family. Pelota subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062280.1">
        <property type="nucleotide sequence ID" value="XM_067206977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KK97"/>
    <dbReference type="SMR" id="A0A836KK97"/>
    <dbReference type="GeneID" id="92360911"/>
    <dbReference type="KEGG" id="loi:92360911"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070651">
        <property type="term" value="P:nonfunctional rRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070966">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, no-go decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070481">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, non-stop decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071025">
        <property type="term" value="P:RNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.870:FF:000002">
        <property type="entry name" value="Protein pelota homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000068">
        <property type="entry name" value="Protein pelota homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.60:FF:000009">
        <property type="entry name" value="Protein pelota homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="entry name" value="eRF1 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.870">
        <property type="entry name" value="Pelota, domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_Pelota-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038069">
        <property type="entry name" value="Pelota/DOM34_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058547">
        <property type="entry name" value="Pelota_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004405">
        <property type="entry name" value="TF_pelota"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00111">
        <property type="entry name" value="pelota"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853">
        <property type="entry name" value="PELOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853:SF0">
        <property type="entry name" value="PROTEIN PELOTA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26356">
        <property type="entry name" value="Pelota_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159065">
        <property type="entry name" value="Dom34/Pelota N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1/Pelota-like N-terminal" evidence="7">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5476047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="406" mass="45445" checksum="23B0BEDC004A634C" modified="2021-09-29" version="1">MRLLGKAAHPDGSMEVRVSVGTSEDLWHLYNFILVGDLVLTKTRRKVSRENALGTLAAEMKMLNLEVEVKQIAFTPDELRIQGVNKGENVFVKTGAHHTLTIHANPPQEVKITKREWDSMCEDRLKDACDESGKADTAAVLMSFGEAQVIHVTSSFMHIKAKIEVTISKKHKGDGKARDKSIERFFKQSLDALVTHVAFDKTKLVLLCSPGHVREEFYAYVKEVSQRAENGPLREVYLNLSKFLLVKVSSTTISGLKEALSDPGVAQRMESTKCVDDIRMWEKFQDIMNRDPDRCVYTPQCVYYAAMAGAVGGLMISDDVFRSENPTERRFFLSLVNFVRQSGSTTVNVFSSKHVTGEQLTQLGSVAAVLRFSCPEIDDMEVVPEFLASKEVEDFIRENATARVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KLA3</accession>
    <name>A0A836KLA3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Raptor N-terminal CASPase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_04404</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062598.1">
        <property type="nucleotide sequence ID" value="XM_067206389.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836KLA3"/>
    <dbReference type="GeneID" id="92360323"/>
    <dbReference type="KEGG" id="loi:92360323"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030307">
        <property type="term" value="P:positive regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001315">
        <property type="entry name" value="Raptor_N-terminal_CASPase_like_domain_containing_protein_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004083">
        <property type="entry name" value="Raptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029347">
        <property type="entry name" value="Raptor_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848:SF19">
        <property type="entry name" value="RAPTOR N-TERMINAL CASPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14538">
        <property type="entry name" value="Raptor_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01547">
        <property type="entry name" value="YEAST176DUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM01302">
        <property type="entry name" value="Raptor_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Raptor N-terminal CASPase-like" evidence="3">
        <location>
            <begin position="112"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="608"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1036"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="628"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1051"/>
            <end position="1065"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5477187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1465" mass="160229" checksum="AED511A1B237EBE0" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KLB6</accession>
    <name>A0A836KLB6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein transport protein Sec61 gamma subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_04450</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">LSCM4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SecE/SEC61-gamma family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062643.1">
        <property type="nucleotide sequence ID" value="XM_067206434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KLB6"/>
    <dbReference type="SMR" id="A0A836KLB6"/>
    <dbReference type="GeneID" id="92360368"/>
    <dbReference type="KEGG" id="loi:92360368"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.820">
        <property type="entry name" value="Preprotein translocase SecE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00422">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023391">
        <property type="entry name" value="Prot_translocase_SecE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008158">
        <property type="entry name" value="Translocase_Sec61-g"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001901">
        <property type="entry name" value="Translocase_SecE/Sec61-g"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00327">
        <property type="entry name" value="secE_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12309">
        <property type="entry name" value="SEC61 GAMMA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00584">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103456">
        <property type="entry name" value="Preprotein translocase SecE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5477232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="69" mass="7780" checksum="4CBF314843E46417" modified="2021-09-29" version="1">MEVLDDILFHPIVAFTKNSRMLVRKCQKPNYNEFTTATIAAVIGFLMMGFLGFFVKLVFIPINNVILGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KMI8</accession>
    <name>A0A836KMI8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prokaryotic-type class I peptide chain release factors domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_05864</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063567.1">
        <property type="nucleotide sequence ID" value="XM_067207794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KMI8"/>
    <dbReference type="SMR" id="A0A836KMI8"/>
    <dbReference type="GeneID" id="92361728"/>
    <dbReference type="KEGG" id="loi:92361728"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="4">
        <location>
            <begin position="540"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="51"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="145"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="214"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="378"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="158"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5479856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="671" mass="71467" checksum="6C92F8FEA802F53C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KMW2</accession>
    <name>A0A836KMW2_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_03172</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CFAP97 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060740.1">
        <property type="nucleotide sequence ID" value="XM_067205188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KMW2"/>
    <dbReference type="SMR" id="A0A836KMW2"/>
    <dbReference type="GeneID" id="92359122"/>
    <dbReference type="KEGG" id="loi:92359122"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038791">
        <property type="entry name" value="Cfap97/Hemingway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029488">
        <property type="entry name" value="Hmw/CFAP97"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23035">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 97-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23035:SF2">
        <property type="entry name" value="KIAA1430 HOMOLOGUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13879">
        <property type="entry name" value="Hmw_CFAP97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="129"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="129"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5471623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="158" mass="18603" checksum="A804FB6FDB00135D" modified="2021-09-29" version="1">MQPKKSSNMASQEREQERNYWLHRDRVASQRSLIDNKTPESCAFVRPIGSMRGNPARSEQVNRDNQKLVQKMVYIMNTRGGVDTSEPWRDKNKAIASQRRRNQEQAVIAQENAKLLGRLEHARPTYRAEKFEADRRRNEEFAARASRYPYQPMDRPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KMW8</accession>
    <name>A0A836KMW8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_03189</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060755.1">
        <property type="nucleotide sequence ID" value="XM_067205203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KMW8"/>
    <dbReference type="GeneID" id="92359137"/>
    <dbReference type="KEGG" id="loi:92359137"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="202"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="675"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="744"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="843"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="677"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="755"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="850"/>
            <end position="862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5471638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="911" mass="97436" checksum="30B31E4CFA9ECD00" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KNT6</accession>
    <name>A0A836KNT6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_01948</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061024.1">
        <property type="nucleotide sequence ID" value="XM_067203987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KNT6"/>
    <dbReference type="SMR" id="A0A836KNT6"/>
    <dbReference type="GeneID" id="92357921"/>
    <dbReference type="KEGG" id="loi:92357921"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="4">
        <location>
            <begin position="90"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5472628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="203" mass="23420" checksum="A34D30BC07EFFE3D" modified="2021-09-29" version="1">MNRVTQLSQSRRGVAIVAAASSATLTVPCRAMHGKPASGHKVRTQHSRRWWMQSKAHHLSAIPHEESRSRPHFPAYTEDVDQPMVVPDGACCFNCDKPVDGDDINSWVWVPSGNARVPTTQGYFFHVRCFKCWSCKYRIIHNQFYSKDGRAWCLSCALGRDIRVPTRRWHTSYVNTHRTGSRLTGQFFPRHRHQIEFLFNPNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KP27</accession>
    <name>A0A836KP27_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">S-adenosylmethionine decarboxylase proenzyme</fullName>
            <ecNumber evidence="3 15">4.1.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">LSCM4_02238</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>S-adenosyl-L-methionine + H(+) = S-adenosyl 3-(methylsulfanyl)propylamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:15981"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57443"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="4.1.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="15">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 15">Amine and polyamine biosynthesis; S-adenosylmethioninamine biosynthesis; S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the eukaryotic AdoMetDC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.50" evidence="3 15"/>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061309.1">
        <property type="nucleotide sequence ID" value="XM_067204272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KP27"/>
    <dbReference type="SMR" id="A0A836KP27"/>
    <dbReference type="GeneID" id="92358206"/>
    <dbReference type="KEGG" id="loi:92358206"/>
    <dbReference type="UniPathway" id="UPA00331">
        <property type="reaction ID" value="UER00451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004014">
        <property type="term" value="F:adenosylmethionine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006597">
        <property type="term" value="P:spermine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.90.10:FF:000009">
        <property type="entry name" value="S-adenosylmethionine decarboxylase proenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.50">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.90.10">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048283">
        <property type="entry name" value="AdoMetDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001985">
        <property type="entry name" value="S-AdoMet_decarboxylase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016067">
        <property type="entry name" value="S-AdoMet_deCO2ase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018166">
        <property type="entry name" value="S-AdoMet_deCO2ase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11570">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11570:SF0">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE PROENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01536">
        <property type="entry name" value="SAM_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001355">
        <property type="entry name" value="S-AdenosylMet_decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56276">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01336">
        <property type="entry name" value="ADOMETDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 19" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="6 15" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="11 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 15" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="13 15" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="12 15" id="KW-0704">Schiff base</keyword>
    <keyword evidence="8 15" id="KW-0745">Spermidine biosynthesis</keyword>
    <keyword evidence="10 15" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5042324218" description="S-adenosylmethionine decarboxylase beta chain" evidence="20">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042324217" description="S-adenosylmethionine decarboxylase alpha chain" evidence="20">
        <location>
            <begin position="90"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid" evidence="16">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for catalytic activity" evidence="16">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for processing activity" evidence="16">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for processing activity" evidence="16">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autolysis" evidence="19">
        <location>
            <begin position="89"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="18">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR001355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001355-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR001355-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR001355-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR001355-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR001355-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAG5472913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="382" mass="43215" checksum="06E9A66C9637355E" modified="2021-09-29" version="1">MSASLPTTKDPLTLMAMWGSMKGYNPEQGFSFEGPEKRLEVILRSTPETHVDGLRSLDDSVWARVVGSLNAQIVSREANAYINSYVLTESSLFVMKNRIILITCGTTTLLNSIPDILEAISAVRGELEWVSFMHKNYSFPWEQKGPHTSLADEFATLKQHFPTGKPYIFGPVDSDHYFLFCYDDIIRPCSSEDDTQLSMTMYGLDKEQTKYWFSDRFISTNAETAAIRAATHLDRVVDDSWTLHDLQFEPCGYSINAIRDEEYQTIHITPEDHCSFASYETNSRAANYLDRMKKVLGVFRPQRFTVIVFLDPESPVGKAYNDGYGIGVEPENYPEYSVQHRTTNEFAPGYVAMKINYVKKTALEEVNAVLGSAGAPVKEKFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KQ35</accession>
    <name>A0A836KQ35_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Aconitate hydratase</fullName>
            <shortName evidence="9">Aconitase</shortName>
            <ecNumber evidence="3 9">4.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_07053</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="9">Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.</text>
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    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>citrate = D-threo-isocitrate</text>
            <dbReference type="Rhea" id="RHEA:10336"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="EC" id="4.2.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the aconitase/IPM isomerase family.</text>
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    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </evidence>
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    </evidence>
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            <dbReference type="Pfam" id="PF00330"/>
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        <source>
            <dbReference type="Pfam" id="PF00694"/>
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    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KQR2</accession>
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        <submittedName>
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    </protein>
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        <name evidence="2" type="ORF">LSCM4_03904</name>
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        <name type="scientific">Leishmania orientalis</name>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
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                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="KEGG" id="loi:92359831"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="317"/>
            <end position="361"/>
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    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="394"/>
            <end position="466"/>
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    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="504"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5474728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="642" mass="72883" checksum="F42AEFF8156A32AA" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KQR7</accession>
    <name>A0A836KQR7_9TRYP</name>
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        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">LSCM4_03919</name>
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        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
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    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061849.1">
        <property type="nucleotide sequence ID" value="XM_067205912.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="518"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="596"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="687"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="333"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="605"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="625"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="643"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="656"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="717"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5474743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="872" mass="92894" checksum="FD61F04AE90A6641" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
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                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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            <end position="69"/>
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    </feature>
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        <location>
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        <location>
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    </feature>
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        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5484341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="293" mass="32455" checksum="64DFC6B7F1DC5091" modified="2021-09-29" version="1">MRLARAHRWWMRPTSRVAADVAATALSVRCLRGSNAPLAVSSPARHCSSSSSSASSSSSTSADRAQGSFSHFRQRQQMFHRHSLYEKGSSVPRGGAGAGADGKQTHGGAAGGGCGSGSSSFSTASSEQQEQDERIYGMASATAQQRREIRQQWEKSFFGRLHYEEGMHSRFAEAFKSEEEEAYRLSIAGQSHADMFPCWPEDGEAPLSEFKQLRPSLQLQYILNRLSSGERRIRYAVDFGSLFMMAQLNLGEMMVREADMLLRELGWMNDEVAAKIEEVQALASKVKYDYDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000011">
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    </dbReference>
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    </dbReference>
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            <dbReference type="EMBL" id="KAG5485359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="74" mass="8163" checksum="F4DB2C0781B3DBA2" modified="2021-09-29" version="1">MVKLRTKDAGPCSDFKERFARNSVISQMVVVNLDRNVPHMITQQVAANIGQLCFVTDVNEAGRSLSWALSSTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KSH2</accession>
    <name>A0A836KSH2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EDRF1 N-terminal domain-containing protein</fullName>
        </recommendedName>
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    <gene>
        <name evidence="3" type="ORF">LSCM4_06662</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
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            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000010">
        <property type="protein sequence ID" value="KAG5485704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067208577.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="loi:92362511"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR15000:SF1">
        <property type="entry name" value="ERYTHROID DIFFERENTIATION-RELATED FACTOR 1"/>
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    </dbReference>
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        <property type="entry name" value="EDRF1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="464"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
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        <location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
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            <end position="40"/>
        </location>
    </feature>
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        </location>
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        <location>
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        <location>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5485704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1517" mass="163140" checksum="10B22D3FEE3877D8" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KTQ9</accession>
    <name>A0A836KTQ9_9TRYP</name>
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        <recommendedName>
            <fullName evidence="6">ENTH domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="7" type="ORF">LSCM4_05284</name>
    </gene>
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        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <location evidence="1">Clathrin-coated pit</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5477893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062800.1">
        <property type="nucleotide sequence ID" value="XM_067207232.1"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A836KTQ9"/>
    <dbReference type="GeneID" id="92361166"/>
    <dbReference type="KEGG" id="loi:92361166"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005545">
        <property type="term" value="F:1-phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03564">
        <property type="entry name" value="ANTH_N"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000063">
        <property type="entry name" value="Putative clathrin coat assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.150">
        <property type="entry name" value="ANTH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011417">
        <property type="entry name" value="ANTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014712">
        <property type="entry name" value="ANTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048050">
        <property type="entry name" value="ANTH_N_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045192">
        <property type="entry name" value="AP180-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951">
        <property type="entry name" value="CLATHRIN ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951:SF5">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-BINDING CLATHRIN ASSEMBLY PROTEIN LAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07651">
        <property type="entry name" value="ANTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0168">Coated pit</keyword>
    <keyword evidence="2" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="6">
        <location>
            <begin position="21"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="317"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="425"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="319"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5477893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="490" mass="54419" checksum="89D210075228B082" modified="2021-09-29" version="1">MNNTDAKQSAGYFKEKATIGLSTFNGDEVLKAVMKVTSHLLKAPKEKYMQRLVAASYGHFGFGLRDGIPINEFIVRELEKRSHTHNWIVVLKTMVSFHRLLCDASDNMVEAICGYRNVFNHSNIKNLADSADGAGQAFLIAQYMTYLKERCVMQNALGKGRRIEIPEFEEYLKTLNAEALHPVFEILLRLFEAVPAVEYREAVVNNFCTMEAYQLLVRDGKQLFHHLAKRIIFVLDGFEEFTLLEKQRWFDLYGRYAGAFASIKQYFDSILCSSRVLVEPVPQLKPLPESLLARLEGDIRASKMAREKPCTLESLGIRSGEDARVDTKEEEIGPQPAPAQAEEKQPAADIVRTPAAPSFSLDDLFVSSDEQAKAVPTNLSSAPWASCPPPTTSFQGEPVQYQWGTGAPANWSTGVPQNWDAGALTTLNANMSPPPTEQQHLVEAGGLPAAKGVPCSGAQSPSKQPPPPVQPKKPADPFKELYNYSHFDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KTT8</accession>
    <name>A0A836KTT8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Archaic Translocase of outer membrane 14 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_05380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5477983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062890.1">
        <property type="nucleotide sequence ID" value="XM_067207322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KTT8"/>
    <dbReference type="SMR" id="A0A836KTT8"/>
    <dbReference type="GeneID" id="92361256"/>
    <dbReference type="KEGG" id="loi:92361256"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5477983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="115" mass="13222" checksum="C3AE4667B35BE083" modified="2021-09-29" version="1">MSAFMEKYHISKALGTTMSAVQSVWGWTRERLWPIYSAAVVISLFQMIAVASEKQILADHYYGDVDGKFEEHKDDLVRDAKKLFNEEVAVAVKEHVWQLPPEAFRREYNSRLGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KU76</accession>
    <name>A0A836KU76_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_07184</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="4"/>
    <dbReference type="EMBL" id="JAFHLR010000015">
        <property type="protein sequence ID" value="KAG5482975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064471.1">
        <property type="nucleotide sequence ID" value="XM_067209088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KU76"/>
    <dbReference type="SMR" id="A0A836KU76"/>
    <dbReference type="GeneID" id="92363022"/>
    <dbReference type="KEGG" id="loi:92363022"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000075">
        <property type="entry name" value="Protein phosphatase 2C, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF565">
        <property type="entry name" value="AT28366P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="7">
        <location>
            <begin position="136"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5482975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="406" mass="44448" checksum="C05C7CCEAE5916CF" modified="2021-09-29" version="1">MKMPSKKKSSNANGSGNGNKLKNGHKGIIVKMKKQAEEDDFEKFLSDLSKTTQHVGQERTEKNVKEERMRDSLRKKHADLAKQRSTNELENVLINRQKSMQLQHLLAELLSTQRSFGSKPVTDFHSESYTSNPNFDVAVGDMQGWRAQMEDAHLVNVGFLSASASGREGFFAVFDGHSGVQSATVCGRIFAKVLARYATPAGDHHHTFDFEKAFLDVDEQLKGALGEGGSGCTAVTVYVSPEEITCAWVGDSRAVLCRKGDAFDLSYDHKPDVVAEKERIEAAGGFVQDNRVNGQLAMSRAMGDFMYKKDTKRSVAQQLVVPVPGVITTKRTSEDSYVAIACDGIFDVLSNKELIELINTKKACGVSNIDICRDVCNRCLAPSSPEGGPAVAEGTDNMTIMIVDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KUW7</accession>
    <name>A0A836KUW7_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_08284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000003">
        <property type="protein sequence ID" value="KAG5488059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066186.1">
        <property type="nucleotide sequence ID" value="XM_067210153.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836KUW7"/>
    <dbReference type="GeneID" id="92364087"/>
    <dbReference type="KEGG" id="loi:92364087"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33472:SF28">
        <property type="entry name" value="BROMO AND FHA DOMAIN-CONTAINING PROTEIN DDB_G0267958"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33472">
        <property type="entry name" value="OS01G0106600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <protein>
        <recommendedName>
            <fullName evidence="4">Leucine-rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_08190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000002">
        <property type="protein sequence ID" value="KAG5488210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066258.1">
        <property type="nucleotide sequence ID" value="XM_067210060.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92363994"/>
    <dbReference type="KEGG" id="loi:92363994"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051341">
        <property type="entry name" value="Zyg-11_UBL_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12904">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12904:SF31">
        <property type="entry name" value="LEUCINE-RICH REPEAT PROTEIN (LRRP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1229"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="402"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1232"/>
            <end position="1243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5488210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1407" mass="149830" checksum="DFCAB16A90DA3536" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FNS4</accession>
    <name>A0A836FNS4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Iron-binding zinc finger CDGSH type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_01310</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059057.1">
        <property type="nucleotide sequence ID" value="XM_067203366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836FNS4"/>
    <dbReference type="SMR" id="A0A836FNS4"/>
    <dbReference type="GeneID" id="92357300"/>
    <dbReference type="KEGG" id="loi:92357300"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.90">
        <property type="entry name" value="CDGSH iron-sulfur domain, mitoNEET-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052950">
        <property type="entry name" value="CISD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018967">
        <property type="entry name" value="FeS-contain_CDGSH-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042216">
        <property type="entry name" value="MitoNEET_CISD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46491">
        <property type="entry name" value="CDGSH IRON SULFUR DOMAIN PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46491:SF3">
        <property type="entry name" value="CDGSH IRON-SULFUR DOMAIN-CONTAINING PROTEIN 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09360">
        <property type="entry name" value="zf-CDGSH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00704">
        <property type="entry name" value="ZnF_CDGSH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iron-binding zinc finger CDGSH type" evidence="6">
        <location>
            <begin position="29"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Iron-binding zinc finger CDGSH type" evidence="6">
        <location>
            <begin position="73"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5466167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="120" mass="13857" checksum="E5ECFC267EAB9E6D" modified="2021-09-29" version="1">MQRCRLLTASWKTKVDPANPRRIVHLPNRTPCMVPLEAGRKYYWCSCGLSKTQPFCDGAHRAYNEEHKTDLQPKEFTVETSKKYLLCRCKHTDNSPYCDLSHIGVLFRTMVGIEKIPGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FP54</accession>
    <name>A0A836FP54_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Kinetoplastid PH-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_01558</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059297.1">
        <property type="nucleotide sequence ID" value="XM_067203606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836FP54"/>
    <dbReference type="GeneID" id="92357540"/>
    <dbReference type="KEGG" id="loi:92357540"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058803">
        <property type="entry name" value="PH_38"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26289">
        <property type="entry name" value="PH_38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetoplastid PH-like" evidence="2">
        <location>
            <begin position="380"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5466407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="586" mass="62554" checksum="E41AF1F8BBB701B6" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FYC3</accession>
    <name>A0A836FYC3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Calpain catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_03130</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060699.1">
        <property type="nucleotide sequence ID" value="XM_067205147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836FYC3"/>
    <dbReference type="SMR" id="A0A836FYC3"/>
    <dbReference type="GeneID" id="92359081"/>
    <dbReference type="KEGG" id="loi:92359081"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015232">
        <property type="entry name" value="DUF1935"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036310">
        <property type="entry name" value="Smp-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF423">
        <property type="entry name" value="LEUCINE-RICH REPEAT PROTEIN (LRRP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09149">
        <property type="entry name" value="DUF1935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101601">
        <property type="entry name" value="Smp-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="4">
        <location>
            <begin position="224"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5471582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="734" mass="81913" checksum="F85AC0139EB7D357" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FZK2</accession>
    <name>A0A836FZK2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="10">1.2.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_00247</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = (2R)-3-phospho-glyceroyl phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10300"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 10">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.12" evidence="10"/>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058437.1">
        <property type="nucleotide sequence ID" value="XM_067202336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836FZK2"/>
    <dbReference type="SMR" id="A0A836FZK2"/>
    <dbReference type="GeneID" id="92356270"/>
    <dbReference type="KEGG" id="loi:92356270"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18126">
        <property type="entry name" value="GAPDH_I_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05214">
        <property type="entry name" value="GAPDH_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000001">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000001">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836">
        <property type="entry name" value="GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836:SF76">
        <property type="entry name" value="GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4 7 10" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding" evidence="11">
        <location>
            <begin position="2"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="11"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="148"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="208"/>
            <end position="209"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="8">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5464806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="331" mass="35515" checksum="7382AAAFBAB9A115" modified="2021-09-29" version="1">MVKVGINGFGRIGRVVFRAAQTRSDIEIVGINDLLDAEYMAYMLKYDSTHGRFNGTVEVRDGALVVNGKAIRVTRERDPASLKWGSIGAEVVVESTGLFLTQETAHKHIQAGAQRVVMTGPPKDDTPMFVMGVNHTTYAGQLIVSNASCTTNCLAPLAKVVNEKYGIVEGLMTTVHATTATQKTVDGPSMKDWRGGRGAAQNIIPSSTGAANAVGKVYPPLNGKLTGMAFRVPTPNVSVVDLTVRLEKPATYKEICAAIKAASQGEMRGILGYTDDEVVSTDFNGVALTSVFDAKAGISLNEHFVKLVSWYDNETGYSHKVLDLISYTSAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G1V3</accession>
    <name>A0A836G1V3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flagellar Member 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059166.1">
        <property type="nucleotide sequence ID" value="XM_067203475.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92357409"/>
    <dbReference type="KEGG" id="loi:92357409"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052752">
        <property type="entry name" value="NACHT-WD_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19871">
        <property type="entry name" value="BETA TRANSDUCIN-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19871:SF14">
        <property type="entry name" value="DUF4062 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5466276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1784" mass="192055" checksum="1905F27789F1507D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G2C4</accession>
    <name>A0A836G2C4_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_01698</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059436.1">
        <property type="nucleotide sequence ID" value="XM_067203745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G2C4"/>
    <dbReference type="GeneID" id="92357679"/>
    <dbReference type="KEGG" id="loi:92357679"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5466546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="392" mass="43504" checksum="3F801DE7A5AE026D" modified="2021-09-29" version="1">MNEVGTLLLRVVSTSPERAPLALLLKNHARLERHGARGIRCPLGTVYGEMSTGARAFFKTVASPVIGFGIGWAGFTLVEQKGLLSESMQRWLNVHNLKLQLFTQRLLPASVVEKYGYPEDTLRSMIELLEKGYTEADVAGRMSFDEVLRQCAVPEQVAYLEEHASEEIPYFYIADIFHSWANLNVNSFLRQPQHTLMGTATNAATATSPVTTAATSSAPVLRNDEAFDSEVLCSSLWEKMIHNVIPFDVSIRALCVLAVNNRANARRLARLSSPERVIELYNAYQDKIQSDQQRDNAPNLVSPEEVTAATLFYLRAVNDASIRKPWIPLLSVPRADPYPLVGKVQPELWCRAFGKLTPAATRSASEAAVLFADVMSERLRCVEPRASETVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G4H7</accession>
    <name>A0A836G4H7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">rRNA adenine N(6)-methyltransferase</fullName>
            <ecNumber evidence="6">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_01251</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058999.1">
        <property type="nucleotide sequence ID" value="XM_067203308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G4H7"/>
    <dbReference type="SMR" id="A0A836G4H7"/>
    <dbReference type="GeneID" id="92357242"/>
    <dbReference type="KEGG" id="loi:92357242"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000179">
        <property type="term" value="F:rRNA (adenine-N6,N6-)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727:SF26">
        <property type="entry name" value="RRNA ADENINE N(6)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA adenine methylase transferase N-terminal" evidence="8">
        <location>
            <begin position="135"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="227"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="512"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="241"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="286"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5466109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="534" mass="58810" checksum="80752D16A133D9A5" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G6G1</accession>
    <name>A0A836G6G1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_02339</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5468946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059923.1">
        <property type="nucleotide sequence ID" value="XM_067204371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G6G1"/>
    <dbReference type="SMR" id="A0A836G6G1"/>
    <dbReference type="GeneID" id="92358305"/>
    <dbReference type="KEGG" id="loi:92358305"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015149">
        <property type="term" value="F:hexose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17315">
        <property type="entry name" value="MFS_GLUT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF8">
        <property type="entry name" value="FACILITATED GLUCOSE TRANSPORTER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="472"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="505"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="541"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="584"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="109"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="16"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5468946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="630" mass="68328" checksum="888B630A8CEA21F2" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G8M7</accession>
    <name>A0A836G8M7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_04591</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062783.1">
        <property type="nucleotide sequence ID" value="XM_067206574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G8M7"/>
    <dbReference type="GeneID" id="92360508"/>
    <dbReference type="KEGG" id="loi:92360508"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
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        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="580"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="293"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="342"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5477372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="656" mass="74794" checksum="0B72E7F82B9AAA84" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G8R4</accession>
    <name>A0A836G8R4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CHCH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060517.1">
        <property type="nucleotide sequence ID" value="XM_067204965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G8R4"/>
    <dbReference type="GeneID" id="92358899"/>
    <dbReference type="KEGG" id="loi:92358899"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5470251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="132" mass="14701" checksum="047D1AFF26D1F6A9" modified="2021-09-29" version="1">MANDTEEASSSAAEVAAAAPTKSPYQQLAYSPLRNESPNAFDEDKYGRARTHIAGLGHVSAKDVFKHYRRSYLTPFFGSNETEPDAQPKGAPHPCQRFSREVHTCLEANHNSFAFCQTRVAAFKQCLREFSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GBJ7</accession>
    <name>A0A836GBJ7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PRA1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_02470</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060051.1">
        <property type="nucleotide sequence ID" value="XM_067204499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GBJ7"/>
    <dbReference type="GeneID" id="92358433"/>
    <dbReference type="KEGG" id="loi:92358433"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004895">
        <property type="entry name" value="Prenylated_rab_accept_PRA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19317">
        <property type="entry name" value="PRENYLATED RAB ACCEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19317:SF0">
        <property type="entry name" value="PRENYLATED RAB ACCEPTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03208">
        <property type="entry name" value="PRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="48"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="76"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5469074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="372" mass="41617" checksum="5EED9BEFA55BC9DB" modified="2021-09-29" version="1">MPLSDASNSLLPPGSLQGTGNRAFPSPGSTNVRKVPLLSSRSSQNDYAGQSDTSDGSAAASGQHRGGHVGSVSGDSDSDLYSEGESEDNDNPAERPVSMALPAFQPNRFRDSAHGNSSGLDAKRANGSPKSMPVSYFNSSKVSSLSLRYEIDCYVWLLRYVYKKIEADRLPWMTDFADMEKMELPRKAKEIAGRLNLNIPYYFSNYLEIFYVVTMPLLLVYNIPFFVVTFLTVVLIHSIRMRKKSTCVYGDGVVVLGRSIGYRKLGHLLLLALAVLFLFFHGLRTLLWVLLLNFCVIVPHALMRKPTYFDDEDLEKCRPKLGQYAICLAILVLAYLEGDACDDEEAENRRAVERERRRLAQVLAKREAKEQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GC01</accession>
    <name>A0A836GC01_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BAG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_01761</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000022">
        <property type="protein sequence ID" value="KAG5479172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063265.1">
        <property type="nucleotide sequence ID" value="XM_067203806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GC01"/>
    <dbReference type="SMR" id="A0A836GC01"/>
    <dbReference type="GeneID" id="92357740"/>
    <dbReference type="KEGG" id="loi:92357740"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.120">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036533">
        <property type="entry name" value="BAG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003103">
        <property type="entry name" value="BAG_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02179">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63491">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAG" evidence="2">
        <location>
            <begin position="399"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="220"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="256"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5479172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="454" mass="49184" checksum="2A9DBE50315EBD02" modified="2021-09-29" version="1">MAYYGYQPEQTKAQIRSTRGETIDLALPITCQVGELRTFLIEEYGYDPDTRLLYNGFIADDKSFVCDYPFGSLMIATPADTQPQRQSLLPRQAAGAHQPPQKQQQQQPPPPPPPEPPHPTADLPQSVSTSTDAARKNKAADLMPNYANTAKRKMSPAEATLETLKAKRDNTVMKRRPKYSARQIRSTSTESAGSQSWTTKGDGASATASLHPAPSPTPPAATSNSTSPAPGSARTLSGGGQHNSSWPQGSKDAHMAPSSAAPSQAANSPSSARTSTPAEVPIGERSNSEECQRQRVRLTVECHIPSLQQVVPVPMNGESSVLDLIQAVAAAVPALTPEAQVVYRGKLLPKSPQAKLFDSGIRSDARVFIAAGDYSNAEKITLLEIEEDTAVIERAMSSQLTDLQRKGYYEELMRILFRTDGLQSLEGEWRQRRKDAVKHITSLQDALGVDVKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GD69</accession>
    <name>A0A836GD69_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_02662</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5469974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060240.1">
        <property type="nucleotide sequence ID" value="XM_067204688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GD69"/>
    <dbReference type="GeneID" id="92358622"/>
    <dbReference type="KEGG" id="loi:92358622"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="318"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5469974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="368" mass="40035" checksum="12B9609A1C2F6369" modified="2021-09-29" version="1">MAFSTLPYITRDVATEPPTTIVIVPCGGQPPALLSKDEAVFAVTEDCVEPTKGWINREGKPLLTVCFMHSFGKCVGRTNSNPATCFQIHIKANVLHALRRHYTSPTRRFFTRTVKALLSPELRQLLCMRAHKEFKVQYLEYRVSDVFPSAGLLQYEDTYRRWLFSDDTSAEHAGTITVLQCLQFSVTGSCNSGTDCPYIHADLKKAQARDPMLACALRDLSDVTRGLPTVPVCVLRSLQPSHQLSFSPVDDAYPQNGMPSDLPRIITKVPGCAVARGEEKSDEYLAPPQMFEYASSTRLVLGHADGAHQFDRMSFVTHGETAPGKPVPESGNIAKTSDGKSGSGWVSSGNEGVSSSGQQTGSSGSGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GG03</accession>
    <name>A0A836GG03_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_07028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000018">
        <property type="protein sequence ID" value="KAG5481317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063996.1">
        <property type="nucleotide sequence ID" value="XM_067208933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GG03"/>
    <dbReference type="SMR" id="A0A836GG03"/>
    <dbReference type="GeneID" id="92362867"/>
    <dbReference type="KEGG" id="loi:92362867"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5481317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="118" mass="13121" checksum="DC3C385FB64F72F4" modified="2021-09-29" version="1">MQGGLRRLAAGSGRAGGSSVVSPAMVTPSRALSVRTEDFFSKEAISHARRVSWAPHTTDKKTGAFAKLARSNFGDPLPESFHSEPYFEEEIEAYRAHHRPDVYVYKYNVSPTHLSLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GG43</accession>
    <name>A0A836GG43_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_00050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058241.1">
        <property type="nucleotide sequence ID" value="XM_067202140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GG43"/>
    <dbReference type="SMR" id="A0A836GG43"/>
    <dbReference type="GeneID" id="92356074"/>
    <dbReference type="KEGG" id="loi:92356074"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000064">
        <property type="entry name" value="Protein phosphatase 2C 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5464610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="298" mass="32686" checksum="B9C351D51036854B" modified="2021-09-29" version="1">MGDMLAKPETQKFSTVFETSHLRVGCCSMQGWRKSMEDAHVAQLNLNGNKEQAFFGVFDGHQSDEASRYCRAHMLDELLKNIAIYRDDVAKAFEVSFHEVDKQICKKYVSSGTTANCVYLDGQQIVCANAGDSRAVLYRGGKVVPLSVDHKPSVPSEEARIVAAGCQVENGRVNMTLAVSRALGDVDFKSNSSKSWVEQAVTSCPDITVTPSQSDDEFIIIGCDGIWDVLSNEECCNLVKTLIQNGEIDKNGHPVAVDISLVCEQVLDRCLAQSNSVKAGTDNMTIIVVEFKPPFFKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GIS7</accession>
    <name>A0A836GIS7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA 3'-terminal phosphate cyclase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_01344</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059090.1">
        <property type="nucleotide sequence ID" value="XM_067203399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GIS7"/>
    <dbReference type="SMR" id="A0A836GIS7"/>
    <dbReference type="GeneID" id="92357333"/>
    <dbReference type="KEGG" id="loi:92357333"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.20:FF:000005">
        <property type="entry name" value="RNA re-capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013791">
        <property type="entry name" value="RNA3'-term_phos_cycl_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023797">
        <property type="entry name" value="RNA3'_phos_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037136">
        <property type="entry name" value="RNA3'_phos_cyclase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000228">
        <property type="entry name" value="RNA3'_term_phos_cyc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016443">
        <property type="entry name" value="RNA3'_term_phos_cyc_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020719">
        <property type="entry name" value="RNA3'_term_phos_cycl-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036553">
        <property type="entry name" value="RPTC_insert"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03400">
        <property type="entry name" value="18S_RNA_Rcl1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096">
        <property type="entry name" value="RNA 3' TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096:SF1">
        <property type="entry name" value="RNA 3'-TERMINAL PHOSPHATE CYCLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01137">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05189">
        <property type="entry name" value="RTC_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="EPT/RTPC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01287">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase" evidence="5">
        <location>
            <begin position="3"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase insert" evidence="6">
        <location>
            <begin position="175"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5466200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="362" mass="39180" checksum="CE88923F42A952CC" modified="2021-09-29" version="1">MLHFEGSSLLRHHIVCSILSKRPVRITNIHDDEDPMGIHVHEANFLKFIDRVTSGSSLQCTDHNTTLQFTPGMILGGSFSHEVPSQRCVTYVIEAALLLLPFAKFDSRITFVGATQGELDLSVDTVRTVTLRWVQLFGVQASLRIIRRGAAPGGGGAVELDIKAIRRLTSATTKERGRVRRIRGIAFASRTAADLPQRAATAAKGELLNLLPDVYVVTDVDNSRANRNERVSGYGVVLVAETTSKLCVISQEAVALPQESPEDVGKRAAQLLFDQIYEGGCVDAHHQMLVLLLMALSPDEISTVRFGQLTASGVSALMLMDSYFGVSCAIKPDPSFAGPNLPPSSLVTCLGSNAVNVWKKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GJN0</accession>
    <name>A0A836GJN0_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_02309</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5468917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059894.1">
        <property type="nucleotide sequence ID" value="XM_067204342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GJN0"/>
    <dbReference type="GeneID" id="92358276"/>
    <dbReference type="KEGG" id="loi:92358276"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5468917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="106" mass="11333" checksum="B7E5AC328A24C873" modified="2021-09-29" version="1">MSVIATTISGDTIALDISAQNVYGFHPGQIVHFTKSLRNGKVALIRGVGDGLIWFAVLPDVASAATEEALQAPVHSVSCRCKEELIRQYGWVADDTFNPYAMAPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GK15</accession>
    <name>A0A836GK15_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_02509</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060089.1">
        <property type="nucleotide sequence ID" value="XM_067204537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GK15"/>
    <dbReference type="GeneID" id="92358471"/>
    <dbReference type="KEGG" id="loi:92358471"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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                <person name="Bates M.D."/>
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                <person name="Jariyapan N."/>
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                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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    <dbReference type="KEGG" id="loi:92358005"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5472712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="218" mass="23869" checksum="81312F049C5EBD02" modified="2021-09-29" version="1">MSVTAQIFSTSLPDGMNPELWVLDGAELVAIPSLDSECSHPSNLGAAKGGIASSDCGSDAEDAVDVSDGGAFKSELVCIGEAAVAPVSFGAAAQVFGDRAAPPSMPKAQLLLQRIGRDYLSRRHAHFLLTLSISWVEITLMRRVALGFLTRRRMGVEYFAHHWAKRHLAHWELRNRSAVVAQSVVRGFNARQRAQRLQRRVLTRIELRSALEQPDPDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GSE5</accession>
    <name>A0A836GSE5_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_06248</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000020">
        <property type="protein sequence ID" value="KAG5480481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063812.1">
        <property type="nucleotide sequence ID" value="XM_067208172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GSE5"/>
    <dbReference type="GeneID" id="92362106"/>
    <dbReference type="KEGG" id="loi:92362106"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="744"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="892"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1011"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="699"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="903"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="924"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="967"/>
            <end position="976"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5480481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1266" mass="130448" checksum="256ADC375CE57445" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GSH5</accession>
    <name>A0A836GSH5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Pteridine transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_07837</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Folate-biopterin transporter (TC 2.A.71) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000006">
        <property type="protein sequence ID" value="KAG5487347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065844.1">
        <property type="nucleotide sequence ID" value="XM_067209714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GSH5"/>
    <dbReference type="GeneID" id="92363648"/>
    <dbReference type="KEGG" id="loi:92363648"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039309">
        <property type="entry name" value="BT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004324">
        <property type="entry name" value="FBT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00788">
        <property type="entry name" value="fbt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31585">
        <property type="entry name" value="FOLATE-BIOPTERIN TRANSPORTER 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31585:SF51">
        <property type="entry name" value="TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03092">
        <property type="entry name" value="BT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="367"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="495"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="532"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="575"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="617"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="632"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5487347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="649" mass="71383" checksum="3F792CB4D156EE5D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GSK7</accession>
    <name>A0A836GSK7_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_02571</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060150.1">
        <property type="nucleotide sequence ID" value="XM_067204598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GSK7"/>
    <dbReference type="SMR" id="A0A836GSK7"/>
    <dbReference type="GeneID" id="92358532"/>
    <dbReference type="KEGG" id="loi:92358532"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="386"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="62"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="186"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="410"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="449"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="464"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5469173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="485" mass="54511" checksum="D811EB81AEFE5041" modified="2021-09-29" version="1">MFNDSSEKYSLVDESMNRLQSENRGGYAANEYTTVEDFAQSTTTVTSAVGPAAGDSRGGASYAEYMAVKAQLEEARAAHEHRMQEITQSSLGCDINSLPSLEELRRERVRLSEQVRHHKDEQDSLALDIEGLDGAGDVYQLAARVQRLEHFVNRAMQYTEEALPLEISKAVEEDRYQSNLELGAYIQDLQRRRANTLKKVADAQEIMSRRSQLQNAADNAAANPEYEDPMEAKAARHTQENKDECVMLQQKIRKFRSMITKLRSDISKESKDSKKMEERMCSCIRNMELANARDARLCKELNNRNSAGTTNSQLLMDQLNVEHYGFDSAPKTKQLLEDIKDRQAMGEWTLGDQQQDMRDASFASFGSPQSRTNSITASQRAVKLPMVALKRTESQRARDNASREDREEFQQSLRRSSSTGNYLLSRGASLSKPPLVAMKPTASQQSRDTALREEREEAMAFRSGQRSSSLGSDARTPTSMAKLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GSW8</accession>
    <name>A0A836GSW8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_08017</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">LSCM4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000005">
        <property type="protein sequence ID" value="KAG5487572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065860.1">
        <property type="nucleotide sequence ID" value="XM_067209893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GSW8"/>
    <dbReference type="SMR" id="A0A836GSW8"/>
    <dbReference type="GeneID" id="92363827"/>
    <dbReference type="KEGG" id="loi:92363827"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050205">
        <property type="entry name" value="CDPK_Ser/Thr_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24349">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="19"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5487572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="429" mass="47501" checksum="E5DE42CCBEE89160" modified="2021-09-29" version="1">MTALPFPLIEDIGELYMLDDIYDFLGEGTFASVFKAVSTVNRDVVQENQTVALKMIAKRKLSSDKLVRDVINEVHVLRQTAHPNCVRFIECVQTPAYVVIVTEFVEGVELFQALKEQKFTEAMVLNVMRQLLSALAYLHNTLHIVHRDVKPENVIIATQETPFRVVLVDFGLARSCERKRPRISRELATHLQRQRPIPVQNLSVESLDCDSPMLATPCGTLKYAAPETVQSITQSAQLSTTKKLLSRLDVYAAGVIMYVMLSGALPFKNFANKASLVMEMRNSLTFDGPRWAGISSEAIDLNKALLNFDAVSRPRAAEALQYPWFKIYGSSLLPMSTEKAHSTPGSPLDSSICERGAMTHAFEAMRATETALYYNEEETTPASAPVTSHSGLRTPNSRCVSVPFGTNALAFSNSSNNSTTAQSGYFDFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GU72</accession>
    <name>A0A836GU72_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Complex 1 LYR protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_07123</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000018">
        <property type="protein sequence ID" value="KAG5481411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064090.1">
        <property type="nucleotide sequence ID" value="XM_067209027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GU72"/>
    <dbReference type="SMR" id="A0A836GU72"/>
    <dbReference type="GeneID" id="92362961"/>
    <dbReference type="KEGG" id="loi:92362961"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13675">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13675:SF1">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="4">
        <location>
            <begin position="195"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="91"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="163"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="91"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="123"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="172"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5481411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="268" mass="30253" checksum="E2E90042C174EEDE" modified="2021-09-29" version="1">MRECLHFTRVMRHQRHDKGGNAHNFPFDTLTKVYRDAVYVPQEGYRGNPMHPERDRGASSAPLRCFDITDHVGKTGAMSPVATKLSEWMVRQHEEEDPSDRRGTGHTSATSSLATPIARSKVASSIHSPASSAAASTAEGMPVDDEAVRRRLRAHLFSVRNESGRQAVAGQPRSASSTPAAAVSTSTRRSGVQAEILSVYRSMLREVARMQDTDTRRDLSAYIRQEYDKQRDIPRKNIMKIEWKLNYSKRKLEELQAMSKHTKFTIMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GVF1</accession>
    <name>A0A836GVF1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromatin target of PRMT1 protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061001.1">
        <property type="nucleotide sequence ID" value="XM_067203964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GVF1"/>
    <dbReference type="GeneID" id="92357898"/>
    <dbReference type="KEGG" id="loi:92357898"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5472605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="228" mass="26985" checksum="43086CAA986E804C" modified="2021-09-29" version="1">MPRDDFDRRRLRALYDRNRHRVAALADARDRRRGGDDDYAAPRRYVVSERRTRIEGFGRGGTQVRRVLRRTRGGRAGEPLPRRFSDRGIFRRSGGDRFRRADDFEREERRDRFLEERARRGGGRHVEGRRFGEARRLRLRMRGTRAGRGDRSRAKVEGRREPEERGGGGRRRQEVVRKSNNNQGNRGGNKQGGQPRNNQPRSTKKPQRSREPQLTREELDRQLESYRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GVJ7</accession>
    <name>A0A836GVJ7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_05912</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063615.1">
        <property type="nucleotide sequence ID" value="XM_067207842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GVJ7"/>
    <dbReference type="SMR" id="A0A836GVJ7"/>
    <dbReference type="GeneID" id="92361776"/>
    <dbReference type="KEGG" id="loi:92361776"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="100"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="46"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5479904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="154" mass="17286" checksum="82F30A892452F916" modified="2021-09-29" version="1">MNPSRMEEQLLHAEISDLGLTALGALVREQCLDNARIDARLSRLEERAGLPPQAELETTQKRPTCSSCDGGEPKNTVLSPEEVDVSAHNSPADDRAAPMCDYCFLFSSNCFSCPGCGREWYCSAACQRLRHRYHAPRCRQQYLPQTRFQTRAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GVM2</accession>
    <name>A0A836GVM2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent protease subunit HslV</fullName>
            <ecNumber evidence="6">3.4.25.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_00431</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP-dependent cleavage of peptide bonds with broad specificity.</text>
            <dbReference type="EC" id="3.4.25.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase T1B family. HslV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.2" evidence="6"/>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058614.1">
        <property type="nucleotide sequence ID" value="XM_067202513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GVM2"/>
    <dbReference type="SMR" id="A0A836GVM2"/>
    <dbReference type="GeneID" id="92356447"/>
    <dbReference type="KEGG" id="loi:92356447"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009376">
        <property type="term" value="C:HslUV protease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01913">
        <property type="entry name" value="protease_HslV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000002">
        <property type="entry name" value="ATP-dependent protease subunit HslV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022281">
        <property type="entry name" value="ATP-dep_Prtase_HsIV_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03692">
        <property type="entry name" value="ATP_dep_HslV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003964">
        <property type="entry name" value="PRK05456.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF7">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE SUBUNIT HSLV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0888">Threonine protease</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00052385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00066335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00074399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5464983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="214" mass="23535" checksum="FB428632170ED49C" modified="2021-09-29" version="1">MLRRLVNRSTSFVTGAAVQARHTTILSVRKGNKVILIGDRQVTLGERIVAKSSACKLRKLNDNVVIGFAGSTADAFALMEKLENKLNDFPDQLSRAAVELAKDWRTDRALRRLEASLIVCNKEETLEIDGQGNVITPEEDGIIAIGSGGTYAKAAARALIDVDGYDAERIARKAMKIATDIDVFSNSNWDVEMLTREEEAVQKEEAEKAEKAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GVM5</accession>
    <name>A0A836GVM5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_03897</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061828.1">
        <property type="nucleotide sequence ID" value="XM_067205891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GVM5"/>
    <dbReference type="GeneID" id="92359825"/>
    <dbReference type="KEGG" id="loi:92359825"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002738">
        <property type="entry name" value="Putative ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF159">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="446"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5474722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="769" mass="82591" checksum="71EDBCA5146E8B12" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GVN2</accession>
    <name>A0A836GVN2_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_00446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="236" mass="26528" checksum="1A762B31F7ECDF13" modified="2021-09-29" version="1">MGKPGRPAEKGTFAERVVDALCSVFSLRIALSSIYLSLVVLLCTLQGMSLFYSPLIHMMNIQSSRIVGAKTFLSEKWFKVEETIYGANATLEVDIMLWAIKVDINVEIPYGFSPQNISQLYRVQDVPCAEFRSTLTKMQIFSILSIFTGCFVWVFTVSNFFTRMFLPLLWLFLWTTIAFTATTVAMMFRILCEGACYGEADEIPPLITVAMPVGGFALALICFQTYLITSLMTVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GX53</accession>
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        </submittedName>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="544"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="383"/>
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        </location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="EMBL" id="KAG5473505.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GX80</accession>
    <name>A0A836GX80_9TRYP</name>
    <protein>
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        <alternativeName>
            <fullName evidence="16">Flap structure-specific endonuclease 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">LSCM4_04099</name>
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            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13 16">Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="16">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts with PCNA1 and PCNA2. Three molecules of FEN1 bind to one PCNA trimer with each molecule binding to one PCNA monomer. PCNA stimulates the nuclease activity without altering cleavage specificity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Nucleus</location>
            <location evidence="16">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Nucleus</location>
            <location evidence="16">Nucleoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Mitochondrion</location>
        </subcellularLocation>
        <text evidence="16">Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14 16">Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="16"/>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062025.1">
        <property type="nucleotide sequence ID" value="XM_067206088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GX80"/>
    <dbReference type="SMR" id="A0A836GX80"/>
    <dbReference type="GeneID" id="92360022"/>
    <dbReference type="KEGG" id="loi:92360022"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09907">
        <property type="entry name" value="H3TH_FEN1-Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09867">
        <property type="entry name" value="PIN_FEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000009">
        <property type="entry name" value="Flap endonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000016">
        <property type="entry name" value="Flap endonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00614">
        <property type="entry name" value="Fen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023426">
        <property type="entry name" value="Flap_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF9">
        <property type="entry name" value="FLAP ENDONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 16" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 16" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8 16" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 16" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1 16" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="19">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="18">
        <location>
            <begin position="150"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="364"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="386"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00063178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAG5475517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="395" mass="44300" checksum="C5D43321CB00ABFE" modified="2021-09-29" version="1">MGILGLSKLLYDKSPNAIREQELKNFFGRRIAIDASMSIYQFIIAMKGFQDGQGMELTNEQGEVTSHLNGLFARTLRMIDEGIKPIYVFDGKPPNLKADELELRRQRAAEAEREFEKAKDAGDDEMMERMSKRTVRVSREQIDESKRLLQLMGVPVIQAPSEAEAQCAELVKKGKAWAVGTEDMDALTFGSTIMLRHLNTGDAKKRPVAEIHLDEVLQATGLSMDQFIDLCILLGCDYVPKVPGIGPQKAWEGIQRYGSIELFLESLDPTKHTVPPDFYYKEARAFFQHPEVTRAEEIDIQFSEPDEAGLIQFLVKEKLFNPDRVNKGIARLRAALTKKTQGRLDSFFTITKLPVQVAATHAPLAGTKRPRDGKSVHISGTLRKTTSGHKKAVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GXI5</accession>
    <name>A0A836GXI5_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_04266</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062190.1">
        <property type="nucleotide sequence ID" value="XM_067206253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GXI5"/>
    <dbReference type="GeneID" id="92360187"/>
    <dbReference type="KEGG" id="loi:92360187"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5475682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="622" mass="68673" checksum="8FE999750A46548E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GXJ3</accession>
    <name>A0A836GXJ3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_06541</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ATG8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000019">
        <property type="protein sequence ID" value="KAG5480969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063970.1">
        <property type="nucleotide sequence ID" value="XM_067208458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GXJ3"/>
    <dbReference type="SMR" id="A0A836GXJ3"/>
    <dbReference type="GeneID" id="92362392"/>
    <dbReference type="KEGG" id="loi:92362392"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000309">
        <property type="entry name" value="Autophagy-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004241">
        <property type="entry name" value="Atg8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10969">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02991">
        <property type="entry name" value="ATG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4 5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="lipid moiety-binding region" description="Phosphatidylserine amidated glycine; alternate" evidence="5">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604241-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5480969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="120" mass="13451" checksum="355184E899CD57E5" modified="2021-09-29" version="1">MTSRVAGSYKKAHSLEARLRDAEKVRERAPDRILVICEKAENSPVPDLDKSKFLVPPDATVGGFLVSIRRRITMEAEKALFLFVGDSVPANSTLMSDLFNRYKDEDGFLYVTYSGENTYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H0M4</accession>
    <name>A0A836H0M4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TAP42-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_04490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062683.1">
        <property type="nucleotide sequence ID" value="XM_067206474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H0M4"/>
    <dbReference type="GeneID" id="92360408"/>
    <dbReference type="KEGG" id="loi:92360408"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051721">
        <property type="term" value="F:protein phosphatase 2A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035303">
        <property type="term" value="P:regulation of dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.540">
        <property type="entry name" value="TAP42-like family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038511">
        <property type="entry name" value="TAP42/TAP46-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007304">
        <property type="entry name" value="TAP46-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10933">
        <property type="entry name" value="IMMUNOGLOBULIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10933:SF9">
        <property type="entry name" value="IMMUNOGLOBULIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04177">
        <property type="entry name" value="TAP42"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5477272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="473" mass="53334" checksum="E423DFCDD9F40DDD" modified="2021-09-29" version="1">MPSSMDATRDYVTAKGHFTKLCDAYITDVVNTSLASTDATLNRHIHSLLAEFELFWHHLSAVSAFSPNDEIDDYSTTALEMLWTPYILADLFQRIQGPMKRIQDGRAANGGGSRNSTTQPQAGSADERMRGEEVLCDSVQGNGTQQTETAARSLVYGTSQSLREEELGSLSRQEALARSHTWLQIFFEWMENIKLVDMKTLDTYSVYRADQRSQRLELSRTIASLREAWKAEEDRVGYLRAKRRRMRELMAEEGEAAEETGGEEEEALRARAVARLKWSIYEGCHQLQISSRERSMLETLNPEQRAAISKQYQDTLDAVRRGELSLGRHTYTILPGGMMAAGTGDRPQQVRVSDIVQSGGVTAPAVTMTATASSSRALSGYQSTQLYRQQVRDELMIDRNAPTMTLQEFAELEMAEVQRQMDEAQAMQQRQAEEDARLGPDGVEERQRQKDSAWDDWKDDHPAYGLTNKGNYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H2S6</accession>
    <name>A0A836H2S6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Centrosomal protein of 19 kDa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_02321</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CEP19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5468928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059905.1">
        <property type="nucleotide sequence ID" value="XM_067204353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H2S6"/>
    <dbReference type="GeneID" id="92358287"/>
    <dbReference type="KEGG" id="loi:92358287"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034454">
        <property type="term" value="P:microtubule anchoring at centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097712">
        <property type="term" value="P:vesicle targeting, trans-Golgi to periciliary membrane compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029412">
        <property type="entry name" value="CEP19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31539:SF1">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 19 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31539">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 19K CEP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14933">
        <property type="entry name" value="CEP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="339"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5468928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="366" mass="41174" checksum="B5CAF406BF2E7EE1" modified="2021-09-29" version="1">MAVDDLGAELWALVHHLFRKYRRDPRKAVQELALRTHVEWTTQPGVPLPKIASHVTQSHWYQEMCSRHASMLEALRLQHERDIVDAGELVSSLYPAGCNVSEYAEALRTCAAVLPCLVPADAIDHLIQQRGADFRDRGLHEVSRDELVSDVIEGLMIRVLTPRQWWCRMASSVARATRTGFRANPPTLYIEYERPAGVPHVRCIHLPANLRPDMPTAQLARRLATTHEALLSEAQFQSLLIRCQRFQRQSSASLSVVTPPTRAAVLKVVTVLPPTTVDEPSTDARTVRGSKPQKADVGLLYRDPDAALENVDLNDADDVTLQEFKEVMNERFKANLVRPGDPGYVYDKRLKVPKPAQSSEWDDDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H437</accession>
    <name>A0A836H437_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Adenine DNA glycosylase</fullName>
            <ecNumber evidence="4">3.2.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LSCM4_03975</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes free adenine bases from 7,8-dihydro-8-oxoguanine:adenine mismatched double-stranded DNA, leaving an apurinic site.</text>
            <dbReference type="EC" id="3.2.2.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.31" evidence="4"/>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061904.1">
        <property type="nucleotide sequence ID" value="XM_067205967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H437"/>
    <dbReference type="SMR" id="A0A836H437"/>
    <dbReference type="GeneID" id="92359901"/>
    <dbReference type="KEGG" id="loi:92359901"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034039">
        <property type="term" value="F:8-oxo-7,8-dihydroguanine DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035485">
        <property type="term" value="F:adenine/guanine mispair binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032357">
        <property type="term" value="F:oxidized purine DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000701">
        <property type="term" value="F:purine-specific mismatch base pair DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000002">
        <property type="entry name" value="Adenine DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044298">
        <property type="entry name" value="MIG/MutY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42944">
        <property type="entry name" value="ADENINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42944:SF1">
        <property type="entry name" value="ADENINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="15">
        <location>
            <begin position="89"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="475"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG5474798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="497" mass="54756" checksum="3DB62F7DC102517E" modified="2021-09-29" version="1">MSRRSACKPSTRGEWLTPLGSSATHEYFRSVQEEVIRWWRQHQRQDLPWRQTLPRDSGGGSEALPGEKYSTGATTARYDPYQVWVSEVMSQQTRMETVIPYYTAWMKKFPSIEALAASTEDEVRSVWAGMGYYRRAMYLRKGAQYLLEWSKQREENAVSCMPSFQEELLKVPGIGPYTSAAIASMCFGEPVCCVDGNVIRVLSRLRGERDFDPKAPANVKEATAWGQELMGNSPTTSAVVCRDPSALNQGLMELGASVCRPSGMPLCTSCPLQQFCRASALLQCGDIEAIEGVIPVRAAKIAKRSAREICVVHEMSAGSTSGTRRFVVVRRPGGGLLGGMLEFPTVSASAADSDEVAVPVFKHPLSALTWKARAKPTGIRVCGRVRHLFSHIVMDVDVVHVKWPADADEAALLKRVAEVVDDHCTGNACNRFPAAARIFVMSEADLRESAPSRLMLKVLQTISSVAVERVRDRNAEKSAIQESAGSLSPPKKVARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H4J9</accession>
    <name>A0A836H4J9_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000010">
        <property type="protein sequence ID" value="KAG5485729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065313.1">
        <property type="nucleotide sequence ID" value="XM_067208602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H4J9"/>
    <dbReference type="GeneID" id="92362536"/>
    <dbReference type="KEGG" id="loi:92362536"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5485729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="236" mass="25984" checksum="EAE1CC518F601BA5" modified="2021-09-29" version="1">MRPAGASATRIAFSPPPHASRSSPRPTFLPTPHVPIHAPRFSPRPTALVLPTVPRPPAAPPASHRPGDLPPAQPGPGPRGVPHEEAERETPGAPRNPRRPTPGPPATRTGRREKPPNGDKEHARARAGRRRGEADDPQQSRRRRRRRRPPRRPRRAPAAGASVGAQLTAGSTHHGGALDRLHFEHVGRVEKRCRHHRNAGATSSRIRSPHWAERVLERGHVKTLLPRLMRSSITFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H5H1</accession>
    <name>A0A836H5H1_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_05890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063593.1">
        <property type="nucleotide sequence ID" value="XM_067207820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H5H1"/>
    <dbReference type="GeneID" id="92361754"/>
    <dbReference type="KEGG" id="loi:92361754"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="285"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5479882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="539" mass="58820" checksum="D54F547F24082598" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H5V3</accession>
    <name>A0A836H5V3_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_05970</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OPA3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000011">
        <property type="protein sequence ID" value="KAG5485334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065071.1">
        <property type="nucleotide sequence ID" value="XM_067207897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H5V3"/>
    <dbReference type="GeneID" id="92361831"/>
    <dbReference type="KEGG" id="loi:92361831"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019216">
        <property type="term" value="P:regulation of lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010754">
        <property type="entry name" value="OPA3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12499:SF0">
        <property type="entry name" value="OPTIC ATROPHY 3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12499">
        <property type="entry name" value="OPTIC ATROPHY 3 PROTEIN OPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07047">
        <property type="entry name" value="OPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5485334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="354" mass="37139" checksum="5C55548C2EF93926" modified="2021-09-29" version="1">MVALPAFKFAFLAIRQVTRPVARQIVSRANTKRALTYCVCIGLGRVSLGLSGVISEWTRAEEQKQKAAKRKSEETNAEADETALASRASVATIAAVQSMGVAGKASATASGCETASTVGSSGSTTTTSTATPVSSAAKAPAIDAEESSLAATSAATPATVTPRSRSLLQSVVYGPQPKGKVVDTYDSTVFLDPSRTVGEAARVFIRYPTRSAWDVFRQTFLAPFPEDRLVAAGADLLIELVAYTVLCTLLVVELNQQSRIAAAKEAYLQSRLEAIESKVNELVEYSNSAASSPPVQELHPVQELRVTGRLSGLWGAVTGGIGFAGGALLRRSRIGDKGGADDSGGRLAGEEREQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H5Y3</accession>
    <name>A0A836H5Y3_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060683.1">
        <property type="nucleotide sequence ID" value="XM_067205131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H5Y3"/>
    <dbReference type="GeneID" id="92359065"/>
    <dbReference type="KEGG" id="loi:92359065"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5471566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="208" mass="22549" checksum="290E9F15978E7FCB" modified="2021-09-29" version="1">MESPSADGQTSHLTAAEAEGEQRTVMPDGAEGEEEHHSDTTASDTNVTSGAASEAEQDGEDDDGDAADEEGDEEDDEEDEEADDGDESDEEEEEERQVYPLPPLPPVHAPAKVHGIATAEVYSIIKELRRQMDDPVEREHAKAMLQGDTDVLLAVAQVLQEAHLLRRATVNDHGVVEEQLVPQPAAARPSLPTGYNSWIVEAPTHARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H6B8</accession>
    <name>A0A836H6B8_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_06113</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000020">
        <property type="protein sequence ID" value="KAG5480347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063678.1">
        <property type="nucleotide sequence ID" value="XM_067208038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H6B8"/>
    <dbReference type="GeneID" id="92361972"/>
    <dbReference type="KEGG" id="loi:92361972"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032546849" evidence="3">
        <location>
            <begin position="29"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5480347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="316" mass="35794" checksum="34707B913E1E4C95" modified="2021-09-29" version="1">MKHSLVRDRTCFLLVTLLVLLGTTAVRAYSVRYAGKTSEHGLMNFETLGYCAQDDTGHSMMPKLQSYQISAAEVLSNNNFDTAPIGGESRQSACLDVNCAWQFNHGLHYRNEITFFFGIVYEGKLRGGPADGVYNNFAAGQPLWWSNVSYWGGRQPYMMRGGQWANGNVVTYYKQWVCEYYEYQQSDVSIFPTYPDGQFIVGHPTGNYYHCGRLVEVDSQGRWIYQRCKEPFPWWASLVIAIIIFVSLVALVLLICCCRFYSERAKIRKERDTKLETLADNPAQVPTQTQMGLSRTPSRHGSDPPSTDDCPSAESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H821</accession>
    <name>A0A836H821_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Symplekin C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_03347</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060910.1">
        <property type="nucleotide sequence ID" value="XM_067205358.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92359292"/>
    <dbReference type="KEGG" id="loi:92359292"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021850">
        <property type="entry name" value="Symplekin/Pta1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022075">
        <property type="entry name" value="Symplekin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15245:SF20">
        <property type="entry name" value="SYMPLEKIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15245">
        <property type="entry name" value="SYMPLEKIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12295">
        <property type="entry name" value="Symplekin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Symplekin C-terminal" evidence="2">
        <location>
            <begin position="1339"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="986"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="360"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="997"/>
            <end position="1011"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5471793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1488" mass="162330" checksum="4AA78571D514B7EB" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HB80</accession>
    <name>A0A836HB80_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061506.1">
        <property type="nucleotide sequence ID" value="XM_067205569.1"/>
    </dbReference>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000003">
        <property type="protein sequence ID" value="KAG5487997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066124.1">
        <property type="nucleotide sequence ID" value="XM_067210091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HKP2"/>
    <dbReference type="GeneID" id="92364025"/>
    <dbReference type="KEGG" id="loi:92364025"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5487997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="155" mass="17591" checksum="88B86E0C8AF272C6" modified="2021-09-29" version="1">MLRRTVRRATGNSHFSGSKERDRIEQERRRRLLYDAAGNLQVGGLLYIMYHDFKKPAAIGLGMVAFLYSYNRLIVHLSREEEAEGLRLDAKSEAMARQTGKLKADRYLIKPNRQIDDPDFLNIPAFGGRGVSSSRLLSDDTVSGGPLHSERNRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HNW0</accession>
    <name>A0A836HNW0_9TRYP</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_07603</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000012">
        <property type="protein sequence ID" value="KAG5484833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064945.1">
        <property type="nucleotide sequence ID" value="XM_067209485.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836HNW0"/>
    <dbReference type="GeneID" id="92363419"/>
    <dbReference type="KEGG" id="loi:92363419"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="809"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1058"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1274"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="61"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="137"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="271"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="481"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="643"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="818"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="837"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="867"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="885"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1120"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1169"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1229"/>
            <end position="1243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5484833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1346" mass="147209" checksum="1E208B72FB80CB8E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836HP39_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosomal RNA-processing protein 8</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_06121</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">LSCM4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Probable methyltransferase required to silence rDNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the methyltransferase superfamily. RRP8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="JAFHLR010000020">
        <property type="protein sequence ID" value="KAG5480355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063686.1">
        <property type="nucleotide sequence ID" value="XM_067208046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HP39"/>
    <dbReference type="SMR" id="A0A836HP39"/>
    <dbReference type="GeneID" id="92361980"/>
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    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:methylation"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007823">
        <property type="entry name" value="RRP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042036">
        <property type="entry name" value="RRP8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12787">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12787:SF0">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05148">
        <property type="entry name" value="Methyltransf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
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            <end position="48"/>
        </location>
    </feature>
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        <location>
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            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5480355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="371" mass="41239" checksum="7ABFE79C6CAFEF65" modified="2021-09-29" version="1">MLGGRHYQRKYDKKQRKKEAKKASKAPARSKDGSRGSSAAAVGAAAKRQGGGTLKGPVVSHGAFMASRDSANNRKNVPFSSKMEEKSYRKEHRVPKYNHIVDPERQNAARAAGASSAAQRRRVLRQKGDEDLLDHFRERLSASTFRLLNEQVYSGPTALASRLLRDESTFRDYHTGYHQQLVQWPMNPNKLIVESLLGDRRGRFLANKGKSMPGHIPPSWMVADMGCGEAQIAAALKPKGYTVHSFDFFALSSLVTVADTSAVPLADSSVDVCIFSLSLMATDYTTSLFEAFRILKPKRLLKIIEVRSRVPFPRKFAELVEDIGFDLDYSDVAGDYFVAFDFIKKDGQAAANTQLRHAPGDVLVPSLYKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HQ07</accession>
    <name>A0A836HQ07_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_08342</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG5481870.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067208856.1"/>
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    </dbReference>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <authorList>
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                <person name="Gatherer D."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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                <person name="Al-Salem W.S."/>
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<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="282"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="409"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="619"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="668"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="686"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="717"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="802"/>
            <end position="822"/>
        </location>
    </feature>
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        <location>
            <begin position="834"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="876"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="887"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="909"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1079"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1250"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1608"/>
            <end position="1621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5487630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1634" mass="170231" checksum="BD2817328C5439FD" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836I440</accession>
    <name>A0A836I440_9TRYP</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">LSCM4_08063</name>
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        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000005">
        <property type="protein sequence ID" value="KAG5487618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
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            <begin position="284"/>
            <end position="302"/>
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        <location>
            <begin position="396"/>
            <end position="424"/>
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        <location>
            <begin position="444"/>
            <end position="477"/>
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    </feature>
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        <location>
            <begin position="9"/>
            <end position="57"/>
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            <begin position="606"/>
            <end position="616"/>
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        <location>
            <begin position="627"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="667"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="715"/>
            <end position="725"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <begin position="753"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
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            <dbReference type="EMBL" id="KAG5487618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="802" mass="88081" checksum="9E46CE3B9B8E182F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836I4I9_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">LSCM4_07506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000004">
        <property type="protein sequence ID" value="KAG5487828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066025.1">
        <property type="nucleotide sequence ID" value="XM_067209393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836I4I9"/>
    <dbReference type="GeneID" id="92363327"/>
    <dbReference type="KEGG" id="loi:92363327"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="204"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5487828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="316" mass="33678" checksum="15ACFA1DED6CD7C1" modified="2021-09-29" version="1">MAKSSRSKWKKMHRRQRAQAEATNTVKRIRQLNKKLELTVKGGISAVPPQEPEKRFHFLNPELDSHVPNTRKDLNNNYRAELNHVHYDYMKPLKLAPPKTNIHGKTDVNAPHPMTVMYETIDADAPLAGHALTKADMERLARRQEQDVPAAAACAEEDACKEEGNIGSGSDDDGPEEYVFGMEDAAPSRAGAKLKAKAKKEKGLTAPKAKKSAALAVSAAGSSSRMLAAEAAAIASDERGPDHDPRNGGVAAAHKIASMQAMHKKNGTTVSASGTAKMKKVGKPGGSSGTRVVSSGSKAAQKKTGNAKSSSSSSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836K6K6</accession>
    <name>A0A836K6K6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GINS subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_00453</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GINS2/PSF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058635.1">
        <property type="nucleotide sequence ID" value="XM_067202534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836K6K6"/>
    <dbReference type="SMR" id="A0A836K6K6"/>
    <dbReference type="GeneID" id="92356468"/>
    <dbReference type="KEGG" id="loi:92356468"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11712">
        <property type="entry name" value="GINS_A_psf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21694">
        <property type="entry name" value="GINS_B_Psf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.5.50:FF:000001">
        <property type="entry name" value="DNA replication complex GINS protein PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1020:FF:000004">
        <property type="entry name" value="GINS complex protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007257">
        <property type="entry name" value="GINS_Psf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056784">
        <property type="entry name" value="PSF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12772">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12772:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25005">
        <property type="entry name" value="PSF2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160059">
        <property type="entry name" value="PriA/YqbF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication complex GINS protein PSF2 N-terminal" evidence="7">
        <location>
            <begin position="42"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="GINS subunit" evidence="6">
        <location>
            <begin position="101"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="239"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="246"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5465004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="37358" checksum="47BB9E8E2DE8F1E6" modified="2021-09-29" version="1">MSSSMRDGAGGGGGGSSSTGSVSLAVGSLADERAFNNYHMSSFMAMEVPATIVPRFTMDRVDCLGGSYGPFAPNYPIDVPLWLALYFRQTDTCAIQPPDFLRVEYLRDVIERERTNDQGFESLPFYFYEIAKKLTERGGGGGGGSGGNCGSGSDDGDTIPHVVEVVRLVNEIHAMRQQKLKNLMTVFEAEGSPMFIPGVLLTNIVCHELHFLRSSFGIVLQQAASMERQRRQLVRLPPVPIATPGRLSSTAGRPTRTSGESSARTTTTLLRTGTADGDSTTMDVASRMGDDSFIRDRATNSQGSALTAATSVTTAIAMTSGGDTQPDAAADVMPLVQPAVKKRRTLRQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836K970</accession>
    <name>A0A836K970_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">serine O-acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_01015</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.30" evidence="2"/>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059731.1">
        <property type="nucleotide sequence ID" value="XM_067203081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836K970"/>
    <dbReference type="SMR" id="A0A836K970"/>
    <dbReference type="GeneID" id="92357015"/>
    <dbReference type="KEGG" id="loi:92357015"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009001">
        <property type="term" value="F:serine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03354">
        <property type="entry name" value="LbH_SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000015">
        <property type="entry name" value="Serine acetyltransferase, plasmid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3130.10">
        <property type="entry name" value="serine acetyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045304">
        <property type="entry name" value="LbH_SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042122">
        <property type="entry name" value="Ser_AcTrfase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42811">
        <property type="entry name" value="SERINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5467929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="411" mass="45005" checksum="334E17BB6AAD4A45" modified="2021-09-29" version="1">MKRLDRIREALGQLHPRRADGTWAPFHPRLSVSKLKELVECLFFVFFPEFTNPPSYVTPTFSDADSLMEWVIGHIADILTTQIYLAFVLHGDPRAVENTKVLKALGTSRRTRLDWNRRSSPALSLLSMELAGSSGEPGVAAAAESGDPTATSGTPRCRVSFARSLSTAVSPTATGANATVEREAADINVDVNPSFLTNCKRKADAIVTKFVVERLAHVRWLLHTDVEAIFNGDVAASSPSEVILCYPGLRCMVHQRVAHQLHLLGVPQNFTRMLTETAHSETGMDIHPNTTIGHHFFIDHGTGIVIGATAVIGNHVSIYQGVTLGARSFPVDKKTGEKIRDLPRHPIIEDGVTLYANAVVLGRVKIGERSTIGGNCWVVRDVPPFSSIVQKSNRVLQPHERMFLEKDGSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836K9J6</accession>
    <name>A0A836K9J6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein-L-isoaspartate(D-aspartate) O-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.77</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">L-isoaspartyl protein carboxyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Protein-beta-aspartate methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LSCM4_00700</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Initiates the repair of damaged proteins by catalyzing methyl esterification of L-isoaspartyl and D-aspartyl residues produced by spontaneous isomerization and racemization of L-aspartyl and L-asparaginyl residues in aging peptides and proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[protein]-L-isoaspartate + S-adenosyl-L-methionine = [protein]-L-isoaspartate alpha-methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:12705"/>
            <dbReference type="Rhea" id="RHEA-COMP:12143"/>
            <dbReference type="Rhea" id="RHEA-COMP:12144"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90596"/>
            <dbReference type="ChEBI" id="CHEBI:90598"/>
            <dbReference type="EC" id="2.1.1.77"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:12706"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.77" evidence="4"/>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058877.1">
        <property type="nucleotide sequence ID" value="XM_067202776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836K9J6"/>
    <dbReference type="SMR" id="A0A836K9J6"/>
    <dbReference type="GeneID" id="92356710"/>
    <dbReference type="KEGG" id="loi:92356710"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004719">
        <property type="term" value="F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000235">
        <property type="entry name" value="Protein-L-isoaspartate O-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000682">
        <property type="entry name" value="PCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579">
        <property type="entry name" value="PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579:SF0">
        <property type="entry name" value="PROTEIN-L-ISOASPARTATE(D-ASPARTATE) O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01135">
        <property type="entry name" value="PCMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG5465246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="260" mass="28020" checksum="4E30D5BB02CA4C7C" modified="2021-09-29" version="1">MAWRCSSTTNAGMVNALQREGLIKTPEVIQAMRRVDRGWFVNDSAEAYRDQPLPIGFGVTISAPHMHAIMLELVSSSVLSHKNVSRGYRRPLRLLDVGSGSGYMTAAFAALCEAAGQDGVAPMFEVIGVEHVQELQKQSERVLQSHFPAWINEHRVTMLHGDGRKPRSIAGVSVGKGGDAFDVIHVGATAPKDLVPEYLSLLRSGGTLVIPVGGPAKVQELQVFTKGAEGDVTMRHACHVQFVPLTSLNAQLDGDSRVCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KAD3</accession>
    <name>A0A836KAD3_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_00316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Bates M.D."/>
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        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
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            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <subcellularLocation>
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    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LIMR family.</text>
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    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="3" key="1">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061172.1">
        <property type="nucleotide sequence ID" value="XM_067204135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KG33"/>
    <dbReference type="SMR" id="A0A836KG33"/>
    <dbReference type="GeneID" id="92358069"/>
    <dbReference type="KEGG" id="loi:92358069"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008479">
        <property type="term" value="F:tRNA-guanosine(34) queuine transglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="entry name" value="Queuine tRNA-ribosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43530">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43530:SF1">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="tRNA-guanine transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-guanine(15) transglycosylase-like" evidence="3">
        <location>
            <begin position="22"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-guanine(15) transglycosylase-like" evidence="3">
        <location>
            <begin position="202"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5472776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="469" mass="51062" checksum="A72CEF360C512789" modified="2021-09-29" version="1">MPPPSMFTFEENRGPAGKEPMAARSGVFHLPHGPLRTPIFMPVATQGALKGVTVEQLEELDVEIILGNTYHLGLRPGEEVLRALTSRKNAREAAAGTHTSADGIRDNMDGIHFMESWKKNILTDSGGFQMVSLLKLAQITEEGVRFQSTHGSGTAGAVTFAAKTEGSSSASGTTAAASTAAAARDAGKSHDNEGEEEGTYSLLLRPEDSIRIQNAIGGDIMMQLDDVVHTLTVGPRVEEAAKRSIRWLDRCLAANQNRAKQCIFGIVQGALNAELRRYCVKEIIQRTECMGYAIGGLSGGEAKDDFWRIVRLCTKEGLPASKPRYCMGVGYPEDILVCIALGVDMFDCVYACRTARFGSALTSSGKLQLSRREYATDFGPLDPNCSCTTCRTYTRSYLNMIAAKESTAATLLSYHNIAYLINLTRGARSAIEEGCFTTYVQNFFLAYYPARDYPKWVVEALASVEITLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KGM5</accession>
    <name>A0A836KGM5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PTBP1-like RNA recognition motif 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_02753</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060326.1">
        <property type="nucleotide sequence ID" value="XM_067204774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KGM5"/>
    <dbReference type="SMR" id="A0A836KGM5"/>
    <dbReference type="GeneID" id="92358708"/>
    <dbReference type="KEGG" id="loi:92358708"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021790">
        <property type="entry name" value="PTBP1-like_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11835">
        <property type="entry name" value="RRM_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PTBP1-like RNA recognition motif 2" evidence="2">
        <location>
            <begin position="21"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5470060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="521" mass="56903" checksum="3FAA13B7F4FD7A80" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KI66</accession>
    <name>A0A836KI66_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal lipase-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_03169</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060737.1">
        <property type="nucleotide sequence ID" value="XM_067205185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KI66"/>
    <dbReference type="SMR" id="A0A836KI66"/>
    <dbReference type="GeneID" id="92359119"/>
    <dbReference type="KEGG" id="loi:92359119"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051218">
        <property type="entry name" value="Sec_MonoDiacylglyc_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856:SF25">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032544605" description="Fungal lipase-type domain-containing protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="2">
        <location>
            <begin position="96"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5471620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="299" mass="32805" checksum="C4FBCB904B10987D" modified="2021-09-29" version="1">MYRLPPALRTVCGACVVVCALLASVAVAQKPYSFDEAWRAHFFSRAAYCSGRDVQSWTCGAACSSVGAFENRTVLDNMLFGTRGLAGVDHANRQIVVAYRGSDNIQNFLENINVLQVRYDKSSSCGRWCKVHAGFLDAYNSLRQQTRDAVLQLIQENPTYEVLVTGYSLGAAIAVLAAVDLQERLNSLEGSSALKPVSLYTFGGPRVGNSAFAKWVDALLSKGAKYRITHGCDPVVRVPALLWGYAHSTTEVFYRTGSNDSAVVCNDSPGWEDWKCSLGMLSLWVPDHMRYLGDTVFCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KIL7</accession>
    <name>A0A836KIL7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_04193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062119.1">
        <property type="nucleotide sequence ID" value="XM_067206182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KIL7"/>
    <dbReference type="SMR" id="A0A836KIL7"/>
    <dbReference type="GeneID" id="92360116"/>
    <dbReference type="KEGG" id="loi:92360116"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
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    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5475611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="413" mass="45022" checksum="12D38DCCDDD0B875" modified="2021-09-29" version="1">MLRCMGTRCGKRLSFVYRNVRAIPLPEKAERGGEDAFLTLSNVQAVLDGVSWWKENADLNAGLYSAALARSMCEYVEDELFGDAPASSFRLLERGYERCKHSDVLGTCTALVATLQEPQEEIQLKDHYQLVLLDGPSLPISGVSATGAPLAATAAAVVGVSDDAMNHAEIPKESNSGPDAAVTQAATTPDLHQAFARFQRTDGVENYLLDVVYVGDCTMMLIRGGRVCYITEEQAHQLDYPYQLGTGSNDTPKDGVRLLIPVEKGDVVVLGTDGVFDNLYPNRIAELIWPHVERVFRYHGYLQGSDGEPGTTTANSMSNEKNRDIRTLLEDIMAAIDMGANAVMVDATAVSRDKRCDSPYASKCIENGALFEGGKPDDMTLLISIIGECDDEQSTAQFSSSEVAFPVPYRDWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KJ23</accession>
    <name>A0A836KJ23_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NADPH--hemoprotein reductase</fullName>
            <ecNumber evidence="8">1.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LSCM4_03872</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.4" evidence="8"/>
    <dbReference type="EMBL" id="JAFHLR010000028">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_067205866.1"/>
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        <property type="term" value="C:cytosol"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
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        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
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        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF17">
        <property type="entry name" value="NADPH--CYTOCHROME P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-0274">FAD</keyword>
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    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="496"/>
            <end position="513"/>
        </location>
    </feature>
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        <location>
            <begin position="68"/>
            <end position="212"/>
        </location>
    </feature>
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        <location>
            <begin position="261"/>
            <end position="488"/>
        </location>
    </feature>
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        <location>
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            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
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            <end position="61"/>
        </location>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG5474697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="648" mass="72410" checksum="3DAFA4D658571678" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KJB4</accession>
    <name>A0A836KJB4_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Discoba</taxon>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067204119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KJB4"/>
    <dbReference type="GeneID" id="92358053"/>
    <dbReference type="KEGG" id="loi:92358053"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="603"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="653"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5472760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="677" mass="74728" checksum="43C4EBD5694400A2" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KJD8</accession>
    <name>A0A836KJD8_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_02159</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067204194.1"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Hemopexin-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Hemopexin-like_repeat"/>
    </dbReference>
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        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
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        <location>
            <begin position="1157"/>
            <end position="1207"/>
        </location>
    </feature>
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        <location>
            <begin position="901"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1480"/>
            <end position="1521"/>
        </location>
    </feature>
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        <location>
            <begin position="2673"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2743"/>
            <end position="2778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="915"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1487"/>
            <end position="1497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1500"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2744"/>
            <end position="2764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="2765"/>
            <end position="2774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5472835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="3769" mass="405583" checksum="DC429166B7239418" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KJG1</accession>
    <name>A0A836KJG1_9TRYP</name>
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        <name evidence="6" type="ORF">LSCM4_01004</name>
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    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0005730">
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734:SF0">
        <property type="entry name" value="18S RRNA (GUANINE-N(7))-METHYLTRANSFERASE-RELATED"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022691"/>
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    </evidence>
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            <dbReference type="Pfam" id="PF12589"/>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
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        </source>
    </evidence>
    <sequence length="423" mass="46306" checksum="0707506BF0E6EFD6" modified="2021-09-29" version="1">MPAPRPELENPPEVFYNASESRKYTSSTRVRKVQRDMTLRALELLNLPKQEVAVASGVNCSGLLLDIGSGSGLSGDVLTEQGHVWIGVDISRDMLRIAKEDELNYYDLGVVPKAGEAEEELLPSSCNARFDTSHVKWGLITSDDDQEAVNDSGKKQDDGGDDDGESGEGSSSAAAGSGVVPGPHMVEVLQNDIGAGLPFRPGTFDGCVSISVLQWLCHSTKKGEVPQRRMMALFQSLYNALRRGAKAVFQFYPSDPEQVHLITRAAMKCGFSGGVVVDFPHSARAKKYYLVLQAGQVQGGFVPPPALTGEMRAADNDSEDSDADSAYEGEESYGSGEEDGESHDGLHGRDARKRARVGGRDAQHHSKRARASSAHGPKRRRKDNRPVTGTREWVLLKKEERRRRGYQTTADSKYTMRPRKPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">LSCM4_01141</name>
    </gene>
    <organism evidence="3 4">
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        <dbReference type="NCBI Taxonomy" id="2249476"/>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5468053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="136"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="29"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5468053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="263" mass="30082" checksum="8A1A3CB5BA97D99C" modified="2021-09-29" version="1">MLRRSVVIRVYERFEGHVAGDKGHMTLQQACTIFGYQLDEEWTKKDIKKRFQKLALRFHPDNGGTDEQFLALKEAQNLLMTHRHDRGADRAAKGANGEGVVGGINFRRMNYDNLTNTIHRQTADMPENRSFGAQDFALFVAFITAVGLYYFYKTYTTQMRVLRTRWSYTEDAIRADYKGKCPSEGSWHPWVADVEARDCMDDIAILQGSVRRELIDEKRKEAPPVYTPWQPGGPFARHRATARAPEALIDAHVSVRSPSPQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KKN5</accession>
    <name>A0A836KKN5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleoporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000022">
        <property type="protein sequence ID" value="KAG5479194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063287.1">
        <property type="nucleotide sequence ID" value="XM_067203828.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92357762"/>
    <dbReference type="KEGG" id="loi:92357762"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5479194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1304" mass="141646" checksum="2CF6C42FD9D7F3B3" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KKP5</accession>
    <name>A0A836KKP5_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_01813</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000022">
        <property type="protein sequence ID" value="KAG5479224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063317.1">
        <property type="nucleotide sequence ID" value="XM_067203858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KKP5"/>
    <dbReference type="GeneID" id="92357792"/>
    <dbReference type="KEGG" id="loi:92357792"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="36"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="128"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="222"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="340"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5479224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="427" mass="48175" checksum="152C5314F08A32C1" modified="2021-09-29" version="1">MAAARAKAEAARVAVEAAINETTDAREREKAAIAENHAREMESLGEARTRARQVASEQHFHRHRDARRPRSGSAASANGTTETSGGVIMKRRPSSGAAGDAAGTPHFPLSGAPDAAHPQTPEEYAAAIDAMRRECERVAMKDENLEERLQLHSEVVGLRRELAVVQEDAKRLRQQLATAEAVVSASDLTVGKDVTIFEEEAQQSMLQKVWVEESECHNPDTMEWADIDVKNLRERVDAARKKFMAAIEKADSLYMKQEAAINETTDAREREKAAIAENHAREMESLGEARTRARQVASEQHFHRHRGTAKAPPAAVPKEKELTTRQRRLGEVEFRTTEQVFKMKDELAELMEQVKTLKRHLDDCRQATEAKRREYEASLRAIEEEGADAREMKERLLKEEEELKELRADLHGVLHYVRAKNREEEGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KLP4</accession>
    <name>A0A836KLP4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Conserved oligomeric Golgi complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_03013</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060584.1">
        <property type="nucleotide sequence ID" value="XM_067205032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KLP4"/>
    <dbReference type="SMR" id="A0A836KLP4"/>
    <dbReference type="GeneID" id="92358966"/>
    <dbReference type="KEGG" id="loi:92358966"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019465">
        <property type="entry name" value="Cog5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048485">
        <property type="entry name" value="COG5_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049176">
        <property type="entry name" value="COG5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13228">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13228:SF3">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20649">
        <property type="entry name" value="COG5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10392">
        <property type="entry name" value="COG5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 5 N-terminal" evidence="6">
        <location>
            <begin position="5"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 5 helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="655"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="657"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5470318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1032" mass="110000" checksum="7D2877C919998C29" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KLW3</accession>
    <name>A0A836KLW3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">mRNA (guanine-N(7))-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_01755</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">LSCM4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:67008"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="Rhea" id="RHEA-COMP:17167"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.1.1.56"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.56" evidence="1"/>
    <dbReference type="EMBL" id="JAFHLR010000022">
        <property type="protein sequence ID" value="KAG5479166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063259.1">
        <property type="nucleotide sequence ID" value="XM_067203800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KLW3"/>
    <dbReference type="SMR" id="A0A836KLW3"/>
    <dbReference type="GeneID" id="92357734"/>
    <dbReference type="KEGG" id="loi:92357734"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004482">
        <property type="term" value="F:mRNA 5'-cap (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013846">
        <property type="entry name" value="mRNA_cap_enzyme_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004971">
        <property type="entry name" value="mRNA_G-N7_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039753">
        <property type="entry name" value="RG7MT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12189:SF2">
        <property type="entry name" value="MRNA CAP GUANINE-N7 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12189">
        <property type="entry name" value="MRNA GUANINE-7- METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03919">
        <property type="entry name" value="mRNA_cap_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03291">
        <property type="entry name" value="mRNA_G-N7_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51562">
        <property type="entry name" value="RNA_CAP0_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MRNA cap 0 methyltransferase" evidence="8">
        <location>
            <begin position="723"/>
            <end position="1024"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5479166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1031" mass="114054" checksum="50E4B09FD597EB93" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KMI3</accession>
    <name>A0A836KMI3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Surface antigen-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_05849</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063552.1">
        <property type="nucleotide sequence ID" value="XM_067207779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KMI3"/>
    <dbReference type="SMR" id="A0A836KMI3"/>
    <dbReference type="GeneID" id="92361713"/>
    <dbReference type="KEGG" id="loi:92361713"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000233">
        <property type="entry name" value="Leucine-rich repeat receptor-like protein kinase TDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47988">
        <property type="entry name" value="SOMATIC EMBRYOGENESIS RECEPTOR KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5479841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="461" mass="50118" checksum="F37496417068D41F" modified="2021-09-29" version="1">MNIRTDASSMPPLLWYRPPARACALVAVVALVSVLSCIATRAEEGRSMSLYTESQRLNTRKFLDGFVQSMPGLKNLWTGDDFCAWEAVTCVGYGVSISAVEWAQLAVSPGRLPEVPSSDVDVSQVVVTSIMLRANGRNLLGTLPASWGLLRHLRKVHLDRNGLTGSLPPAWSGLNGLVELYLCNNNLTGTLPASWGESMRRLSFLSINRNALVGPLPAEWGRMGSMRSLMLEENQLNGTLPVTWGLLHSLSTLSIGMNNLSGTLPHEWAHMMLMGWMDLNSNYLTGTLPATWATMAFLTALWLSDNRLTGTMPAEWGGLESLEELRLEGNALTGGLPASWSGMTSLTQLRLERNNLDGSLPAAWRSMTRMEVLDVFQNALSGALPASWSSMQHLDTLDVRDNKLCGSLPASWETLPAIQHVHLEGNALCGGLPLNWTSSYVNITVDKLVIGVDCSKANACA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KMJ1</accession>
    <name>A0A836KMJ1_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_06536</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000019">
        <property type="protein sequence ID" value="KAG5480964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063965.1">
        <property type="nucleotide sequence ID" value="XM_067208453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KMJ1"/>
    <dbReference type="GeneID" id="92362387"/>
    <dbReference type="KEGG" id="loi:92362387"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5480964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="394" mass="43129" checksum="364EA1F1EB7A6F5C" modified="2021-09-29" version="1">MKRARYIDAQACQKKMQRAYSIPLFGDCVRHLAEHLESCADVVAVDPMSCIRFYDEDAACTALEALSLLLFDKPSERRTGGMCVHHQTWWGIGVLRGRESDVAYSSGEGASVRWNIVPLALTVVPWQMELPLRLQDLVLRQGHFASMGECDYGGSDVGPIPDTFVAREAVVLLCGLPRCRVQAVSGHFPLFHRVVPPTLSAAPQGISAADTTVSLVPLREVSPLQREAAALQHKRRLTPFVVRGLSSMTESFAPRSYRSVLECWAVVSYPDGLPRAVSARDVVDHASRDPRDTAGAVPVHGLSAHQSVCPCEAPPFFILPTHHLCRSLRVAVGWRKISPSSRPLAEEALRRLCSLVDRVALCTGQGVALRFQTVWSGAQETRSATATIQKASSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KN68</accession>
    <name>A0A836KN68_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glutathione-specific gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="1">4.3.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_01864</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.7" evidence="1"/>
    <dbReference type="EMBL" id="JAFHLR010000022">
        <property type="protein sequence ID" value="KAG5479272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063365.1">
        <property type="nucleotide sequence ID" value="XM_067203906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KN68"/>
    <dbReference type="SMR" id="A0A836KN68"/>
    <dbReference type="GeneID" id="92357840"/>
    <dbReference type="KEGG" id="loi:92357840"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061928">
        <property type="term" value="F:glutathione specific gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.10:FF:000019">
        <property type="entry name" value="Gamma-glutamylcyclotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006840">
        <property type="entry name" value="ChaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12192">
        <property type="entry name" value="CATION TRANSPORT PROTEIN CHAC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12192:SF2">
        <property type="entry name" value="GLUTATHIONE-SPECIFIC GAMMA-GLUTAMYLCYCLOTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04752">
        <property type="entry name" value="ChaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5479272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="322" mass="35534" checksum="850A865024F01551" modified="2021-09-29" version="1">MPNSDIAVYPCHYHGAYQPPAEGSTPVSIAAASLPEITKTQPELRQQHSTKDAPTRYHEELGLPSFDDHIFLIFGYGSILWKQEFEFDAEYEAYIKGYKRVFYQGTCVHRGVPGKPGRVVTLLPSEDKEERVYGKAYQLPAVPEKLNKIFQALDVREGGYARVQLTLFNAHPSTGNLNTTPTLPAPTCKSFRTEGSAQYAPLLRQSSSNVEAGVSEEVLDIFSHPNAPAVQPRKKVVCLCYIATEQNKDYIGEASMEEMASDILSRSGISGSNREYLFFLAESLRAMGATDPHVFELEAVAKRMLLDREAGLAAGAKRLVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KNN6</accession>
    <name>A0A836KNN6_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_05805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063508.1">
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                <person name="Bates M.D."/>
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                <person name="Bates M.D."/>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Bates M.D."/>
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                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <comment type="caution">
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            <begin position="450"/>
            <end position="465"/>
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            <begin position="469"/>
            <end position="481"/>
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        <location>
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    </feature>
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        <location>
            <begin position="730"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF25405"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5488257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Leishmania orientalis</name>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
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                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
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                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Kwakye-Nuako G."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="2">Belongs to the sestrin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        </source>
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        </source>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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            <taxon>Leishmania</taxon>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000015">
        <property type="protein sequence ID" value="KAG5483038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        </location>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836FP19_9TRYP</name>
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        <alternativeName>
            <fullName evidence="9">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LSCM4_01495</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania orientalis</name>
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        <lineage>
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            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="3"/>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059237.1">
        <property type="nucleotide sequence ID" value="XM_067203546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836FP19"/>
    <dbReference type="SMR" id="A0A836FP19"/>
    <dbReference type="GeneID" id="92357480"/>
    <dbReference type="KEGG" id="loi:92357480"/>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07792">
        <property type="entry name" value="ASKHA_NBD_FGGY_GK1-3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000086">
        <property type="entry name" value="Glycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000108">
        <property type="entry name" value="Glycerol kinase, glycosomal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042018">
        <property type="entry name" value="GK1-3_metazoan-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005999">
        <property type="entry name" value="Glycerol_kin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01311">
        <property type="entry name" value="glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000756">
        <property type="entry name" value="PRK00047.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF69">
        <property type="entry name" value="GLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="11">
        <location>
            <begin position="3"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="12">
        <location>
            <begin position="271"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG5466347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="512" mass="55939" checksum="B6626C5423F39F54" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FZ91</accession>
    <name>A0A836FZ91_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_00036</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058227.1">
        <property type="nucleotide sequence ID" value="XM_067202126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836FZ91"/>
    <dbReference type="GeneID" id="92356060"/>
    <dbReference type="KEGG" id="loi:92356060"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5464596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="167" mass="17943" checksum="F20280C323FD52A5" modified="2021-09-29" version="1">MDFEGLLTNEALRPLLSEFALHLMDHSDTASLIARLPPPKTAMLYHAALLRCPTAATTKGERLYQAERLCASVLDAYGLRGGTVKESTPRVHGACTRPVCPMTASDGAAEMTVCPALCRRLAEVEVTHPLLEEALAAREARLQHHIATMFAGAPPSFSTSQMSPSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G293</accession>
    <name>A0A836G293_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Short-chain dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_00245</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058435.1">
        <property type="nucleotide sequence ID" value="XM_067202334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G293"/>
    <dbReference type="SMR" id="A0A836G293"/>
    <dbReference type="GeneID" id="92356268"/>
    <dbReference type="KEGG" id="loi:92356268"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF736">
        <property type="entry name" value="RETINOL DEHYDROGENASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="300"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5464804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="411" mass="44105" checksum="00666059A9C22A6B" modified="2021-09-29" version="1">MILLVFICATLWVIWSAASFFMYRPRHIIGATAVVTGACSEMGRRLCMQLYARGACVIAWDYSKTRLQELQAEVLKAATGAGSSDSASAQRGSHSAGSFRSGTFAVMVVDVSSRLQVQRAAKELQGSLDIIVNAAHTCPSKRLGNRCEDSAERVIQTNVLSPLVVVHQLLPLLLSKSGSSSSASGLFKALQRRDDYAQVVNLVSSAASYTLSSDSPDYAASQWGMVGMHYSMREWIAQQRSEYMTDGGGGAPSERKVGVAAAARVRQPAREVRTTLLCLNEVQQGLSTVASSLLSSSSGMSTTARATSPKAPSSPAGSPESGEGGFTGARGRSTLTFRDSYSQSLQKRKVELDRAAVCCVNAIVRGQERYCYSSAWATTVVYPLLMACPVPWATRLLRWMQRPPAATATES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G2B2</accession>
    <name>A0A836G2B2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tetrahydrofolate synthase</fullName>
            <ecNumber evidence="3">6.3.2.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Folylpoly-gamma-glutamate synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Tetrahydrofolylpolyglutamate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LSCM4_00276</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + L-glutamate + ATP = (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + phosphate + H(+)</text>
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            <dbReference type="Rhea" id="RHEA-COMP:14738"/>
            <dbReference type="Rhea" id="RHEA-COMP:14740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:141005"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.17" evidence="3"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067202364.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="92356298"/>
    <dbReference type="KEGG" id="loi:92356298"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Folylpolyglutamate synthase"/>
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    </dbReference>
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        <property type="entry name" value="Mur ligase, C-terminal domain"/>
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    </dbReference>
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        <property type="entry name" value="Mur-like, catalytic domain"/>
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    </dbReference>
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        <property type="entry name" value="Folylpolyglutamate_synth"/>
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        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF5">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="Mur_ligase_M"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0554">One-carbon metabolism</keyword>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00030592"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00030876"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG5464834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="642" mass="71052" checksum="C2111F7C3F8F82D6" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_00442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
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    </dbReference>
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            <begin position="232"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5464994.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="435" mass="46529" checksum="11F2F6F410FE0F96" modified="2021-09-29" version="1">MQCITNRSYEPTSLLTDCTLAVQHLVSARSLLPPSPTADELLRLLHESGHPCTSSTPPDSNMGVLSSPPASFSAANIIRYCPTSRRVKSSFAAAGAHSMLGEMMQFFAESLTRLFTLGVADASVRAFPSEWDRRLHAPAAASLRRHHLYELQGFSTLFMHVWGQVAASRLLLRDEHGEEQDLVESTQSAAALSSPAMASTSGATARRSAAQQPPSTPPPLSASAATAHPSQPFHQKTSEGSSGNSKSGIAAAHERPCIPLTSAALFFPGAEVAPLSHGGKRRGDGPLSGLSSRSAAQPATLAVFQHALTMQAKAQRPFLPSIPREGLAPASRAREGDGSFPETSSAADRDAPRSLALVPSTSKAAPLYSTSLRTLSVEQGMQLDRQRELRRELGLRRVRNYAAEGDMRDYLSSYQENLRSVLEGEDMDATGSNLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G4S0</accession>
    <name>A0A836G4S0_9TRYP</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">LSCM4_01420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Euglenozoa</taxon>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG5466274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067203473.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92357407"/>
    <dbReference type="KEGG" id="loi:92357407"/>
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    </dbReference>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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    </feature>
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        <location>
            <begin position="513"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
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        <location>
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            <end position="1399"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="86"/>
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        </location>
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        <location>
            <begin position="527"/>
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        </location>
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        <location>
            <begin position="537"/>
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        </location>
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    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="640"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1290"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1360"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1387"/>
            <end position="1399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5466274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1399" mass="145857" checksum="44715832CD328F5A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G4S2</accession>
    <name>A0A836G4S2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Amidinotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_01073</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059788.1">
        <property type="nucleotide sequence ID" value="XM_067203138.1"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="L-arginine/glycine Amidinotransferase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Amdntrnsf_FN0238"/>
    </dbReference>
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        <property type="entry name" value="AMIDINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43224:SF1">
        <property type="entry name" value="AMIDINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19420">
        <property type="entry name" value="DDAH_eukar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55909">
        <property type="entry name" value="Pentein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5467986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="39220" checksum="A794BDD912076067" modified="2021-09-29" version="1">MSSVILVNPIAFGPNPKTTDNALIQSMHVGNAKADMDRSQVCALVTELEAFFKVNCGIHTVVVHQSREPKPYRGPLEDHGESVFVADSLSVHNVVDDDGVIQRRLVVFYPMSPHRQGELARKQLVNHITKVAEESATIELIDLRPFEEEGKYLEGSGSLVFGPGGRYVYTVISQRSHPDVLEALCRPENLNIAPQNRFLLRCKSAVPHTNLLGWCGTGICAWAISSLVFDVEEEEVAFYDHLSESYSCVLELSESEMEKFAGSALEVPVQPRSAGAGSVHPILVISETALAALTPKNRELLLHWYGKENVHTFYGEVLERRCGTSLPSCIAASYTLGSRPPVPTQPSTNEVLRLGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G531</accession>
    <name>A0A836G531_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RNA polymerase III RPC4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_01620</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059359.1">
        <property type="nucleotide sequence ID" value="XM_067203668.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="92357602"/>
    <dbReference type="KEGG" id="loi:92357602"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="RPC4"/>
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        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13408:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05132">
        <property type="entry name" value="RNA_pol_Rpc4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="49"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5466469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="364" mass="37882" checksum="589E37EC75EEF17A" modified="2021-09-29" version="1">MPPKAPNLKFKPKLVLREEGTAARPPPTQATDDLSLVQLARLQGLYVEEQASSSSGAATGPIERLAPTSSSSAHGSGDGGGVRTTVSLSTASAGQPQQHRAHLSNSEDGARGTAVPSLTRPKGRSHNMSAHAALEEASRRHVDISQYPATAPPLPQNSVNTIVLPSASRSSDCMHSGLYVPLPLDASLPSRLAAEECGTLSSGQGAVSGASTSATAVAMDVDGTAFLREAESEKQRAYAANTRFYEDSLRPMQASALSAAAAPGGLVWMQLPRFHENAPFSFFDLPPGKVGELKVLRSGRMLLEIAGVCYDVAVEGYEDAGNDGACAMAVATQPSAYPSNPSSKASCYELGLLQKKLVCTPTVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GBB9</accession>
    <name>A0A836GBB9_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
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            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5468954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059931.1">
        <property type="nucleotide sequence ID" value="XM_067204379.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="92358313"/>
    <dbReference type="KEGG" id="loi:92358313"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5468954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="437" mass="47897" checksum="B9921549D0F1BB1C" modified="2021-09-29" version="1">MNPSATAYVPSTVIASTLAQRRATPPVTATLSSKSPGMSHCQTTTATEVPMTAAERLCNARDKEAHQLKPSAATSAPVSSAPILSSSMCASVADAAAPMPMTPPPLSQGTAFIRYSKEQLLSLRAAAIGSVMRGGIVGHPPFERIPESFAPLLRLPFATEYVNVDAAMQLVEHRTYASPLPSSSLNSIVCTEDLADEAQARLFTCPVCTEGGPQPCAAIQHLLQRARRYAMSTKLGAALMQPALVVESLLRLALVFDAKQSSLRLRMLAEQSPRVVHLVEEYLCGEGYHLPLPPVTAHEEWAALNGILKFDAIRDNKTRVITDLSKHWKKRRTQFEQFVYFFAFRDARPVRPAKNIITQSVKPGMVAMLTGDLRAMVLLHRLGFFIPPDYYWSVFPFLRQSLGEGTLKYDVVRHLGLYLSATQPADMYNPVEKPTHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GBD1</accession>
    <name>A0A836GBD1_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_02913</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060485.1">
        <property type="nucleotide sequence ID" value="XM_067204933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GBD1"/>
    <dbReference type="SMR" id="A0A836GBD1"/>
    <dbReference type="GeneID" id="92358867"/>
    <dbReference type="KEGG" id="loi:92358867"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5470219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="284" mass="33236" checksum="445AEA50142E87FC" modified="2021-09-29" version="1">MLRTTPVFLASRAKGYMNRVMVYAHRRRKARYLAPKNAHVRSPLANKMPEEYGNTWDPRSGVEWHNRMRHRNHYRHWPWARWTDDPVRFHQDSVCRRTVSASSSAANNGTPEWNYYAEVGQAYETPSHFPLSYTAPFIYQYTAHCWSREDLQSYLEHVQQSSGLRTIADVASMKEALYTWWHNAAMDSIPVGVLQHLELVSCDIVAQNARKSYRTKEHERGILRTREMERYYALPHLRGPAMPVQLTQPSGEYPNGKFTQMMEGVAIHPLQRPDARYTHNMYPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GD04</accession>
    <name>A0A836GD04_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_00390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058573.1">
        <property type="nucleotide sequence ID" value="XM_067202472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GD04"/>
    <dbReference type="SMR" id="A0A836GD04"/>
    <dbReference type="GeneID" id="92356406"/>
    <dbReference type="KEGG" id="loi:92356406"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5464942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="294" mass="32614" checksum="E0E05FEEB306B4AF" modified="2021-09-29" version="1">MLRYFLARSSDTAMTTNSADTNVNCNHGAWNEVAHTCDCDDGWCTDWVNQDVLSGKFVYCNSQASTLSPNSTNPTTTSPLVGKSTLIIAVFAIALAASCGIIVFCCYRRKQHLKKEVKQEEILAATTKDREAWLKGGAQLQQMQAQERAALSQQVWIAQLEAQRQNQMMMEQLMNMSAMTANSNPQLSKPSRHRQQHTHEILPPQLGGAPCACDTDYEGGNLLTNTFDRWRSHEPLAQSHSHYRPGATLSTTGSCTGHSKALPLHYTTATFEAPQRGLNSPRRYAHPTNCRPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GD06</accession>
    <name>A0A836GD06_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_05718</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063423.1">
        <property type="nucleotide sequence ID" value="XM_067207650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GD06"/>
    <dbReference type="SMR" id="A0A836GD06"/>
    <dbReference type="GeneID" id="92361584"/>
    <dbReference type="KEGG" id="loi:92361584"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049680">
        <property type="entry name" value="FLVCR1-2_SLC49-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924:SF6">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 49 MEMBER A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="352"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="420"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5479712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="457" mass="50642" checksum="30CCEF18D6AADF7A" modified="2021-09-29" version="1">MMIQDLFARLEKKYQVLLIFIIFTMNNGFAWLMFEPVADWLKTNVHGMTSRTLQLLSSWQPLVFLCMFIPIMKLVTRYDGLRLAVRIGTAAEIVGAAFKLIGAFAHKSSFGLLMLNIGQILSGIGSPVATGAVSALSATWFQPEERTRATAAAVLFNSVGNSLCYIFVPTLTKKLSFSSVTVYELIMAAIALGLAWMVMPQEPESMEVSTEAKDQATLQHSAALELKGEDDVVAHSTEHLDLMTQLRSLWSIPSCVCLLVVYAWLSGGFSAWISLFADTYSKFYSEEFIGIMSFFGMIAYVVGGIASSHLVDLYFSRQMKYVIFFCITMNMLCNLIFIACTPNDKSYSLWNLGQSFIVFSTALCGFWNGAAAPLFYELVAEISFPVEEGVSGICISVMENVGALVFYQVVSRFFTGQSMSVAYSFGMTIAVALSAAVKQRYNRSYHAYLIQNAEEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GDH4</accession>
    <name>A0A836GDH4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">mannose-6-phosphate isomerase</fullName>
            <ecNumber evidence="4">5.3.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_02833</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-mannose 6-phosphate = D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12356"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="5.3.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mannose-6-phosphate isomerase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.8" evidence="4"/>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060405.1">
        <property type="nucleotide sequence ID" value="XM_067204853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GDH4"/>
    <dbReference type="SMR" id="A0A836GDH4"/>
    <dbReference type="GeneID" id="92358787"/>
    <dbReference type="KEGG" id="loi:92358787"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00423"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07011">
        <property type="entry name" value="cupin_PMI_type_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.441.10">
        <property type="entry name" value="Phosphomannose Isomerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001250">
        <property type="entry name" value="Man6P_Isoase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016305">
        <property type="entry name" value="Mannose-6-P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018050">
        <property type="entry name" value="Pmannose_isomerase-type1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046457">
        <property type="entry name" value="PMI_typeI_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046458">
        <property type="entry name" value="PMI_typeI_hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00218">
        <property type="entry name" value="manA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309:SF0">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20511">
        <property type="entry name" value="PMI_typeI_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20512">
        <property type="entry name" value="PMI_typeI_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001480">
        <property type="entry name" value="Mannose-6-phosphate_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00714">
        <property type="entry name" value="MAN6PISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00965">
        <property type="entry name" value="PMI_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00966">
        <property type="entry name" value="PMI_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phosphomannose isomerase type I catalytic" evidence="10">
        <location>
            <begin position="4"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphomannose isomerase type I helical insertion" evidence="11">
        <location>
            <begin position="186"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001480-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001480-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5470139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="423" mass="46416" checksum="DB7EE46DD00B6483" modified="2021-09-29" version="1">MSELIKLDAGYQDYAWGKDASSSFVAKMKGMSNDTSGAKFAELWVGTHPNCPSKIADGSAQLLEDFLRQSENKQRYFSAAHQATNFRDTVPYLLKILSIRTALSIQAHPCKRLAEELHAAQPDKYKDPNHKPELICALTPFEALCCFRPLDAIIANLKKIPELMALVGGDAVLSQLMMAPASALPAPDSDEEKQALKSMMTKLYAAPEDAVAEALRLHLQRLHDRGAQCAEDDVFVRIYGQYPDDVGCWMVYFLNYVQMVPGEALFLSDSEPHAYISGDGVEIMACSDNVVRAGLTPKWKDVSTLISMLKYDTTGLASARHEKKSSEDAAQWQVQYYQPPAQFPDFSLFRMQYDHDSGSGTTSVTLPTIGLGFCLEGSAKVNGAIVKAGECFVVPYGKLTCQAEGTKTLLFVASTNDLSSTHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GDK4</accession>
    <name>A0A836GDK4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">18S rRNA aminocarboxypropyltransferase</fullName>
            <ecNumber evidence="6">2.5.1.157</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_02878</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>an N(1)-methylpseudouridine in rRNA + S-adenosyl-L-methionine = N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine in rRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63296"/>
            <dbReference type="Rhea" id="RHEA-COMP:11634"/>
            <dbReference type="Rhea" id="RHEA-COMP:16310"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
            <dbReference type="ChEBI" id="CHEBI:146234"/>
            <dbReference type="EC" id="2.5.1.157"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TDD superfamily. TSR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.157" evidence="6"/>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060450.1">
        <property type="nucleotide sequence ID" value="XM_067204898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GDK4"/>
    <dbReference type="GeneID" id="92358832"/>
    <dbReference type="KEGG" id="loi:92358832"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106388">
        <property type="term" value="F:rRNA small subunit aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01116">
        <property type="entry name" value="TSR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007209">
        <property type="entry name" value="RNaseL-inhib-like_metal-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022968">
        <property type="entry name" value="Tsr3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007177">
        <property type="entry name" value="Tsr3_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002621">
        <property type="entry name" value="PRK02287.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426:SF0">
        <property type="entry name" value="18S RRNA AMINOCARBOXYPROPYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN TSR3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04068">
        <property type="entry name" value="Fer4_RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04034">
        <property type="entry name" value="Ribo_biogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNase L inhibitor RLI-like possible metal-binding" evidence="9">
        <location>
            <begin position="43"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="16S/18S rRNA aminocarboxypropyltransferase Tsr3 C-terminal" evidence="8">
        <location>
            <begin position="81"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="235"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="254"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5470184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="296" mass="32349" checksum="D52AA80B0F1F0989" modified="2021-09-29" version="1">MGKGVGHTHSGRGRGRGRGSGSGGVCSTSGYHSNEPPAHPCSVPLAMWDFDQCDPNACSGKKLYRLNALRLLRLSEPFHGVVLTPSATEIVSPADRDIVLQKGAAVVDCSWKELDAVPWRKMRMSAPRLLPLLLAANPVNYGRPSKLNCAEALAATLAIVGLMDDARSVMAYFSWGASFFDVNRELLAGYQQCVNSAEVSVFQEKYVEAELRESEARRGLDLDARDLSDARPLNERRGRLKRHHEWQQSSRSEDDGDHEVVENEDSGGEEDTSSSDGCEDSSRCKCAVEEGAEQQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GEA5</accession>
    <name>A0A836GEA5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Protein transport protein Sec24A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LSCM4_03464</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061404.1">
        <property type="nucleotide sequence ID" value="XM_067205467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GEA5"/>
    <dbReference type="SMR" id="A0A836GEA5"/>
    <dbReference type="GeneID" id="92359401"/>
    <dbReference type="KEGG" id="loi:92359401"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF39">
        <property type="entry name" value="SECRETORY 24AB, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="11">
        <location>
            <begin position="291"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="12">
        <location>
            <begin position="368"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="14">
        <location>
            <begin position="620"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="13">
        <location>
            <begin position="718"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="17"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="68"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG5473401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="976" mass="107827" checksum="D41179B75AEA9FAA" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GFJ3</accession>
    <name>A0A836GFJ3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Histidyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LSCM4_01985</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(His) + L-histidine + ATP = L-histidyl-tRNA(His) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="2"/>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061060.1">
        <property type="nucleotide sequence ID" value="XM_067204023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GFJ3"/>
    <dbReference type="SMR" id="A0A836GFJ3"/>
    <dbReference type="GeneID" id="92357957"/>
    <dbReference type="KEGG" id="loi:92357957"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000054">
        <property type="entry name" value="Histidine--tRNA ligase chloroplastic/mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43707:SF1">
        <property type="entry name" value="HISTIDINE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43707">
        <property type="entry name" value="HISTIDYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="12">
        <location>
            <begin position="21"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="458"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="129"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="321"/>
            <end position="322"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001549-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG5472664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="477" mass="53516" checksum="E6FC2AC950284931" modified="2021-09-29" version="1">MTVRMSSTASPNAALLAEINDLKVKLAEKEALLQPEGVVSKRSKKKSQANMIEKEPVQGCRDFPPEDMRVRRYLFGVFHETARKFGFEEYDAPVLESEELYIRKAGEEITDQMFNFVTKGGHRVTLRPEMTPSLVRLQLAKGRSLLLPAKWYSIPQCWRYEAISRGRRREHYQWNMDIVGVKSVAAEVELLCAACAAMESLGLTAQDVGVRVNSRKLLQCALAVAGVPDDLFAAVCVVVDKMEKLPEEQIRAELGALGLDGQQADDIIKTLNLKSIDDFDKDLFNKNGALSELAEFFSQVRMYGYEDWVQFDASVVRGLAYYTGIVFEAFDRSGEFRAICGGGRYDNLFTLYGSPQPVSCVGFGFGDCVIIELLKKKRLLSPLSHKVDDVVIPFNESQRGTALKVLKRLRDKGRSADIILDPKKIAQTFSYADRIGADRAVLIAPDETEKGMARVKMLREGQEREDDRGDLVPFEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GGX9</accession>
    <name>A0A836GGX9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Acyl-CoA dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_04018</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061947.1">
        <property type="nucleotide sequence ID" value="XM_067206010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GGX9"/>
    <dbReference type="SMR" id="A0A836GGX9"/>
    <dbReference type="GeneID" id="92359944"/>
    <dbReference type="KEGG" id="loi:92359944"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000031">
        <property type="entry name" value="Acyl-CoA dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000080">
        <property type="entry name" value="Probable acyl-coA dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025878">
        <property type="entry name" value="Acyl-CoA_dh-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052166">
        <property type="entry name" value="Diverse_Acyl-CoA_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42803">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42803:SF1">
        <property type="entry name" value="BROAD-SPECIFICITY LINEAR ACYL-COA DEHYDROGENASE FADE5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12806">
        <property type="entry name" value="Acyl-CoA_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="9">
        <location>
            <begin position="108"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="8">
        <location>
            <begin position="191"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="7">
        <location>
            <begin position="312"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Acetyl-CoA dehydrogenase-like C-terminal" evidence="10">
        <location>
            <begin position="512"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5474841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="629" mass="68805" checksum="14080B6F576246C4" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GHM3</accession>
    <name>A0A836GHM3_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_00891</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059609.1">
        <property type="nucleotide sequence ID" value="XM_067202959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GHM3"/>
    <dbReference type="SMR" id="A0A836GHM3"/>
    <dbReference type="GeneID" id="92356893"/>
    <dbReference type="KEGG" id="loi:92356893"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5467807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="171" mass="19275" checksum="4A4CA068CA28D8E6" modified="2021-09-29" version="1">MLNWIWNALFGDGPPHRDDDMVRVTMADLRAITTEIETLRQSVEATTQVLASTNSNATLFLQSIEALMLETFDVAAEAAETSPETTEVHEIRANLQQQRATLIETLLQQRELIETRLFHAQVRLRTLERQRESVAAAVEELDNTSHRTGSVVFPAAETPQFLPTTPYRENG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GIT4</accession>
    <name>A0A836GIT4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_01360</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059105.1">
        <property type="nucleotide sequence ID" value="XM_067203414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GIT4"/>
    <dbReference type="SMR" id="A0A836GIT4"/>
    <dbReference type="GeneID" id="92357348"/>
    <dbReference type="KEGG" id="loi:92357348"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF22">
        <property type="entry name" value="DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="375"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="689"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="694"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5466215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="708" mass="77226" checksum="97F5027549083482" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GN03</accession>
    <name>A0A836GN03_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_04091</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062017.1">
        <property type="nucleotide sequence ID" value="XM_067206080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GN03"/>
    <dbReference type="GeneID" id="92360014"/>
    <dbReference type="KEGG" id="loi:92360014"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF275">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00856">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="67"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5475509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="331" mass="37153" checksum="666B5A2BF6A1BAA5" modified="2021-09-29" version="1">MRATSLLAAPPFRPCTASALGFRRPLCTVVSSCFRGSLLVPARTFAKVSTVQGKIEVPPGGFVTADVKIDMNTSFGGAFARGVFAEREIGYGREIMNLPAYCMYIGENDRQPLREQVLIVTKEIFSKVVYGTPQDQQYVKHRILSLMSGGFSYFTRERDVFDFAEEVRAPGADGAFRNGSNCLMSGEFSSYDLQKLPLIVEFNRFDVDYRGRRGICLFPEASYLNHSCEPNVELSITYNSVKSTFFLSARAVRPIREGEELFINYMPGNNLPLSRLALAMKKRWGFECSCVKCKSRAVGAVTVVFVVLLIPIIVYIRCFIVERTKEKHRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GR30</accession>
    <name>A0A836GR30_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_02944</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060516.1">
        <property type="nucleotide sequence ID" value="XM_067204964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GR30"/>
    <dbReference type="SMR" id="A0A836GR30"/>
    <dbReference type="GeneID" id="92358898"/>
    <dbReference type="KEGG" id="loi:92358898"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039328">
        <property type="entry name" value="WDR89"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22889">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22889:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="317"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5470250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="360" mass="38752" checksum="DB9B50233586E9F6" modified="2021-09-29" version="1">MNLLQVVQTSYEPGTYIMNGCLCNGSSSLALSLSTKAIRLYDTQTAAFLADIKEHTQPVQDLVATPAQPTTLYSCQRDCGVMVTDLRQARAAHCFSEMCSSGAVCSSIGITPSAPLLAIAADRDIHLVDTRTWCSVKCLEQLHVDEVSRLRFLDDSILCSAGEDQMINFLSVEEGVVDDDVLVQAVSCGEVITKMNCFPELGVTAMVGSCENGYVFPYDLDQRESRYSRPSFDTYLVDWCMVSGQLHLVSGVRDDNGDAGPLRVLNGATGQTQVLPKVHKELGRVAIGFGNRLITGGEDGMLAYWKHGDVLPSEFTTPVGSNAHRTGGGKVFARSRAHEGDGRRGGGGGGSRRGGRGRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GSB7</accession>
    <name>A0A836GSB7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RESC1/2 CYTH-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_01808</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000022">
        <property type="protein sequence ID" value="KAG5479219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063312.1">
        <property type="nucleotide sequence ID" value="XM_067203853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GSB7"/>
    <dbReference type="SMR" id="A0A836GSB7"/>
    <dbReference type="GeneID" id="92357787"/>
    <dbReference type="KEGG" id="loi:92357787"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="CDD" id="cd23732">
        <property type="entry name" value="RESC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057320">
        <property type="entry name" value="RESC1_2_CYTH-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25477">
        <property type="entry name" value="RESC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RESC1/2 CYTH-like" evidence="2">
        <location>
            <begin position="182"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5479219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="513" mass="56250" checksum="5342C8B6D0EC1DA0" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GTI1</accession>
    <name>A0A836GTI1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S phase cyclin A-associated protein in the endoplasmic reticulum N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_07583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000004">
        <property type="protein sequence ID" value="KAG5487902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066099.1">
        <property type="nucleotide sequence ID" value="XM_067209467.1"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A836GTI1"/>
    <dbReference type="GeneID" id="92363401"/>
    <dbReference type="KEGG" id="loi:92363401"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31434">
        <property type="entry name" value="S PHASE CYCLIN A-ASSOCIATED PROTEIN IN THE ENDOPLASMIC RETICULUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31434:SF2">
        <property type="entry name" value="S PHASE CYCLIN A-ASSOCIATED PROTEIN IN THE ENDOPLASMIC RETICULUM"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="992"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1005"/>
            <end position="1015"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5487902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1061" mass="120593" checksum="9229E24D1380D43E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GU06</accession>
    <name>A0A836GU06_9TRYP</name>
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        <recommendedName>
            <fullName evidence="8">CNNM transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_07016</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000018">
        <property type="protein sequence ID" value="KAG5481306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063985.1">
        <property type="nucleotide sequence ID" value="XM_067208922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GU06"/>
    <dbReference type="GeneID" id="92362856"/>
    <dbReference type="KEGG" id="loi:92362856"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010960">
        <property type="term" value="P:magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045095">
        <property type="entry name" value="ACDP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064">
        <property type="entry name" value="METAL TRANSPORTER CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064:SF94">
        <property type="entry name" value="UNEXTENDED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1 3" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="5">
        <location>
            <begin position="60"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="4">
        <location>
            <begin position="606"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="718"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="718"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5481306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="746" mass="82770" checksum="BF7D7611A2B91A0C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GU32</accession>
    <name>A0A836GU32_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NADPH--hemoprotein reductase</fullName>
            <ecNumber evidence="8">1.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_00508</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.4" evidence="8"/>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058687.1">
        <property type="nucleotide sequence ID" value="XM_067202586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GU32"/>
    <dbReference type="SMR" id="A0A836GU32"/>
    <dbReference type="GeneID" id="92356520"/>
    <dbReference type="KEGG" id="loi:92356520"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000059">
        <property type="entry name" value="5-methyltetrahydrofolate-homocysteine methyltransferase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF17">
        <property type="entry name" value="NADPH--CYTOCHROME P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="10">
        <location>
            <begin position="14"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="11">
        <location>
            <begin position="811"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="412"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="746"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="751"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="762"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="774"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
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        <source>
            <dbReference type="PROSITE" id="PS51384"/>
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        </source>
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</entry>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
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            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <source>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
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    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="191"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5472710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="203" mass="22504" checksum="DC0604EBB3CC3D93" modified="2021-09-29" version="1">MPARLLRGAGLGHARRLPQAVSTKLSCCVPHLHSSFLSSLTEGARASHISFLKEAGYYRLENPKHIIIDPSVYEIRTMRGSGPGGQGTNSSSNKVELRVDMELLSEFFDDELLSALRRSEAGGALTADGTTIVVSCHEHRSALQNKEACLRKLQMLLHKASWVPPVEAGPVERPSFMVTEHKVRRRRKSTMSRMTRSARNGSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GVP0</accession>
    <name>A0A836GVP0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase C51 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_00464</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058644.1">
        <property type="nucleotide sequence ID" value="XM_067202543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GVP0"/>
    <dbReference type="GeneID" id="92356477"/>
    <dbReference type="KEGG" id="loi:92356477"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.10">
        <property type="entry name" value="endopeptidase domain like (from Nostoc punctiforme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007921">
        <property type="entry name" value="CHAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051705">
        <property type="entry name" value="Gsp_Synthetase/Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30094">
        <property type="entry name" value="BIFUNCTIONAL GLUTATHIONYLSPERMIDINE SYNTHETASE/AMIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30094:SF0">
        <property type="entry name" value="BIFUNCTIONAL GLUTATHIONYLSPERMIDINE SYNTHETASE_AMIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05257">
        <property type="entry name" value="CHAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50911">
        <property type="entry name" value="CHAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C51" evidence="2">
        <location>
            <begin position="29"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="418"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5465013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="749" mass="83047" checksum="D9472582A18B6FB1" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GWC9</accession>
    <name>A0A836GWC9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peroxisomal enoyl-coa hydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_07060</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000018">
        <property type="protein sequence ID" value="KAG5481349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064028.1">
        <property type="nucleotide sequence ID" value="XM_067208965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GWC9"/>
    <dbReference type="SMR" id="A0A836GWC9"/>
    <dbReference type="GeneID" id="92362899"/>
    <dbReference type="KEGG" id="loi:92362899"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051750">
        <property type="term" value="F:delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000004">
        <property type="entry name" value="Delta3,5-delta2,4-dienoyl-CoA isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045002">
        <property type="entry name" value="Ech1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149:SF1">
        <property type="entry name" value="DELTA(3,5)-DELTA(2,4)-DIENOYL-COA ISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149">
        <property type="entry name" value="ENOYL-COA HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5481349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="34327" checksum="A348AD229C35E75E" modified="2021-09-29" version="1">MKRCSRLLSTAETLSLIRCIGPFSVHRGEAKGVVEIFFGDPKHPVKKLNLLGLAYAAALKELSELLSEELNAEARVAIFAARDGCSFSAGIDLKELSSMSLPSGGGAAAAAAASSNCKAPAMLLQYQHRLVRAFQDGVSSLARCRIPIIAAIDRHCIGGATSVASACDVRYTTTHATFSVKEAAVGLSADIGVLQRLPAIIGEGRTRELAFTCRDFRGVEAKEMGFVEEVCADYPALLAHARMRAEQIAANSPLGVQNTKLVLNWERERAAQTSLEYQAAINAFSLRCNDIPEAARAFADKRAPVFTDYMVNPTGGLPPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GWI4</accession>
    <name>A0A836GWI4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calpain catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_06196</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000020">
        <property type="protein sequence ID" value="KAG5480429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063760.1">
        <property type="nucleotide sequence ID" value="XM_067208120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GWI4"/>
    <dbReference type="SMR" id="A0A836GWI4"/>
    <dbReference type="GeneID" id="92362054"/>
    <dbReference type="KEGG" id="loi:92362054"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000058">
        <property type="entry name" value="Cysteine peptidase, Clan CA, family C2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015232">
        <property type="entry name" value="DUF1935"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036310">
        <property type="entry name" value="Smp-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF423">
        <property type="entry name" value="LEUCINE-RICH REPEAT PROTEIN (LRRP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09149">
        <property type="entry name" value="DUF1935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101601">
        <property type="entry name" value="Smp-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="3">
        <location>
            <begin position="176"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="419"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5480429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="690" mass="78368" checksum="42471FE1A909FE06" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GX92</accession>
    <name>A0A836GX92_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP-dependent RNA helicase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_07180</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000015">
        <property type="protein sequence ID" value="KAG5482971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067209084.1"/>
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    <dbReference type="SMR" id="A0A836GX92"/>
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    <dbReference type="KEGG" id="loi:92363018"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP-dependent RNA helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="129"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="160"/>
            <end position="347"/>
        </location>
    </feature>
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        <location>
            <begin position="444"/>
            <end position="595"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="386"/>
            <end position="429"/>
        </location>
    </feature>
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        <location>
            <begin position="697"/>
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        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="7">
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            <begin position="129"/>
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        </location>
    </feature>
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        </location>
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        </source>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="KAG5482971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="778" mass="85484" checksum="4A8A2A1B98A367A6" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GXG2</accession>
    <name>A0A836GXG2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_04234</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF649">
        <property type="entry name" value="ACID TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aa_trans"/>
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    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
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        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="247"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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        </location>
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        </location>
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        <location>
            <begin position="418"/>
            <end position="441"/>
        </location>
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        <location>
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            <end position="481"/>
        </location>
    </feature>
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        <location>
            <begin position="79"/>
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        </location>
    </feature>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="EMBL" id="KAG5475652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GY97</accession>
    <name>A0A836GY97_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aminopeptidase</fullName>
            <ecNumber evidence="11">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LSCM4_05013</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9 11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="11"/>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062290.1">
        <property type="nucleotide sequence ID" value="XM_067206987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GY97"/>
    <dbReference type="SMR" id="A0A836GY97"/>
    <dbReference type="GeneID" id="92360921"/>
    <dbReference type="KEGG" id="loi:92360921"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000006">
        <property type="entry name" value="Puromycin-sensitive aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF174">
        <property type="entry name" value="PUROMYCIN-SENSITIVE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 11" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="14">
        <location>
            <begin position="14"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="12">
        <location>
            <begin position="251"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="13">
        <location>
            <begin position="545"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="323"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG5476057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="883" mass="98251" checksum="09C89FC3653F1408" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GYH2</accession>
    <name>A0A836GYH2_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_07161</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GOT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000018">
        <property type="protein sequence ID" value="KAG5481449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064128.1">
        <property type="nucleotide sequence ID" value="XM_067209065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GYH2"/>
    <dbReference type="GeneID" id="92362999"/>
    <dbReference type="KEGG" id="loi:92362999"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045176">
        <property type="entry name" value="Got1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21493">
        <property type="entry name" value="CGI-141-RELATED/LIPASE CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21493:SF9">
        <property type="entry name" value="GOLGI TRANSPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5481449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="143" mass="15721" checksum="40A804C52A115BEF" modified="2021-09-29" version="1">MDSLYNWSDTTKMGVAFTGLGVFFTLMGVVMFLDSILLTMGNVLFVAGVAMVMGPQRCKAFFIARRRASACFFLGIVFVFLRWCFVGLCIQGFGALNLFGNFFPVLARVLESTPVLGPILLSAPVQKVLSLLHVNDGRNLRNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H0B9</accession>
    <name>A0A836H0B9_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_02264</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Bates M.D."/>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <sequence length="122" mass="14163" checksum="EFBF609745E34413" modified="2021-09-29" version="1">MQRLSSGSFVRRMMVAPLLSAAACQTHSRFNSDYVNKAAKKKVEDGDDERWLEAEMDKNIITPEERYAHAREVEALKRMVAQLKDEHKDNLEEAARERNKELEALKKEMSDLQQKISKLTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H0Z0</accession>
    <name>A0A836H0Z0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine hydroxymethyltransferase</fullName>
            <ecNumber evidence="8">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_04964</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Interconversion of serine and glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="8"/>
    <dbReference type="EMBL" id="JAFHLR010000014">
        <property type="protein sequence ID" value="KAG5483809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064748.1">
        <property type="nucleotide sequence ID" value="XM_067206939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H0Z0"/>
    <dbReference type="SMR" id="A0A836H0Z0"/>
    <dbReference type="GeneID" id="92360873"/>
    <dbReference type="KEGG" id="loi:92360873"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000097">
        <property type="entry name" value="Serine hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000586">
        <property type="entry name" value="PRK00011.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF35">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="9">
        <location>
            <begin position="8"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5483809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="465" mass="50753" checksum="1DB0A22F8B36DC4F" modified="2021-09-29" version="1">MASLIPTLAEQDPELANMIELEMGRQFRGLEMIASENLTSKAVLECLGSALTNKYAEGEPGNRYYGGTVYVDMIENLAKKRALAAFGLDPEEWGVNVQPYSGSPANFAVYTALLEPHSRIMGLDLPSGGHLTHGFYTPKKKVSATSIYFESFPYRVKEDGLIDYDALESVALVFRPKMIIAGASAYARDFDYERFRGICDEAGSLLFMDMAHTAGLIAGGALKSPFPYADVVTTTTHKSLRGPRAGMIFYRKKDRQGKPTDYENRINQAVFPGCQGGPHEHQIAAIATQMREVCSQEWKVYAKQVQSNARALAAALSAKGHVFVSGGTDNHLLLWNVRVHGLTGSKMEKLLDAVSISVNKNTIPGDKSAMTPGGIRIGTPSLTSRGMVEADMGTVSEFLHRAVALAKQIQAEVNSVKLSDFVEALRKHAGVAALRADVEAFATTFPMPSFDAERIKYRDSLPEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H216</accession>
    <name>A0A836H216_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5478007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062914.1">
        <property type="nucleotide sequence ID" value="XM_067207346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H216"/>
    <dbReference type="GeneID" id="92361280"/>
    <dbReference type="KEGG" id="loi:92361280"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="599"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="660"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="886"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="603"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="679"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="727"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="754"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="887"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="905"/>
            <end position="915"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5478007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="983" mass="104869" checksum="293096B08531D4ED" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H2G8</accession>
    <name>A0A836H2G8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cilia- and flagella-associated protein 91</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_02548</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CFAP91 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060127.1">
        <property type="nucleotide sequence ID" value="XM_067204575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H2G8"/>
    <dbReference type="SMR" id="A0A836H2G8"/>
    <dbReference type="GeneID" id="92358509"/>
    <dbReference type="KEGG" id="loi:92358509"/>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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            <fullName evidence="7">PWWP domain-containing protein</fullName>
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                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
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        <source>
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        <source>
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    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_067204752.1"/>
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    <dbReference type="KEGG" id="loi:92358686"/>
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    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:microtubule associated complex"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:microtubule binding"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:microtubule-based movement"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
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        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF15">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KINESIN_MOTOR_1"/>
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    </dbReference>
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        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="10"/>
            <end position="338"/>
        </location>
    </feature>
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    </feature>
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            <end position="420"/>
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        <location>
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            <end position="1103"/>
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    </feature>
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            <end position="560"/>
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    </feature>
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            <begin position="93"/>
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        <ligand>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5470038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1118" mass="128096" checksum="5A7BEF32ACED36E8" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H5F5</accession>
    <name>A0A836H5F5_9TRYP</name>
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        <recommendedName>
            <fullName evidence="5">Ppg3-related protein-like protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">LSCM4_05323</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
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        <lineage>
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            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5477930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067207269.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="2">
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        <location>
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            <end position="974"/>
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    </feature>
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        <location>
            <begin position="278"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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    </feature>
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        <location>
            <begin position="944"/>
            <end position="957"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5477930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1009" mass="107535" checksum="AA857665D678A013" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H5I0</accession>
    <name>A0A836H5I0_9TRYP</name>
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        <recommendedName>
            <fullName evidence="2">UBL3-like ubiquitin domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">LSCM4_05905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067207835.1"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Rad60-SLD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBL3-like ubiquitin" evidence="2">
        <location>
            <begin position="35"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5479897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="161" mass="17563" checksum="593203D5BA59B545" modified="2021-09-29" version="1">MQRVRVRCVLTGACMPVYSGRVVQATIPLHQADGSATTVEAMKSQLRSNWPADMNELEDIMGEARICVLKAGCVLNDSDLLEKCLTTAERETCLVSAVETVEERKDALEKPSVLVHLVLQKNRTLPAETSKRERSKSGSTPEGGNSGEGHEVKKDSCCCLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836H6K8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PUM-HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_06249</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000020">
        <property type="protein sequence ID" value="KAG5480482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063813.1">
        <property type="nucleotide sequence ID" value="XM_067208173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H6K8"/>
    <dbReference type="GeneID" id="92362107"/>
    <dbReference type="KEGG" id="loi:92362107"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF50">
        <property type="entry name" value="RNA BINDING PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="4">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="66"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5480482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="246" mass="27033" checksum="E05D8E9D341CDF0D" modified="2021-09-29" version="1">MDAFANYMVQCAIEHSDRTTAAQYVLAHFTGNILQMSCNKHSSNVLEVALRCCGEVPAVRRLFLDELVFNPAALKEAVSDPYGNFVVQALIGVVTNPMEFKRMEDRLHPALVGCQFAAKIEGRVKAKRPGPHHAGGAPHHYSCSQSHQGREEPCAVPWVASYGAETREADGKLCFWARASAAAPGRSSLSGSAKYFRHFPYELPRFVATSFNSIGIRGGGIVFRRRFPQELQRQPLLQSVGADDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H6W7</accession>
    <name>A0A836H6W7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Heat shock protein 70</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_05107</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062381.1">
        <property type="nucleotide sequence ID" value="XM_067207078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H6W7"/>
    <dbReference type="GeneID" id="92361012"/>
    <dbReference type="KEGG" id="loi:92361012"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="435"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5476148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="462" mass="50671" checksum="9209A23E1ADF29C4" modified="2021-09-29" version="1">MDRKADKGEKNVLIFDLGGGTFDVTLLTIESGVFEVKATAGDTHLGGEDFDNRLVDYFATELKTRCGKDCRVNARATRRLRTACERVKRTLSSSTTANIEIDALYEGNDFFSKITRARFEEMCRDQFEKCLEPVKKVLADADMKPQDVNDVVLVGGSTRIPKIQQMVSQFFGGKELNRSINPDEAVAYGAAVQAHILAGGQSSKTDGLLLLDVTPLSLGVETAGGVMSVLIPRNSTMPVQKTQTYSNNAENQRNVEIKVYEGERPLVSQCQCLGTFTLTDIPPMPRGKARINVTFDVNTDGILVVSAVEESGGRKEAITIQNDTGRLSKDQIERMVREAEKFAEEDRANSERIEARNLLENYTFSMRATLDDPDVQNGISQEDRQKIHAAVSCAADWLDGNPEATKDEYMEQTKRVEAVAHPILSEYYKKRVMEAPPSAGSAATQESGGAAPGAGPHSEDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H856</accession>
    <name>A0A836H856_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SKP1 component POZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_08049</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000005">
        <property type="protein sequence ID" value="KAG5487604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065892.1">
        <property type="nucleotide sequence ID" value="XM_067209925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H856"/>
    <dbReference type="GeneID" id="92363859"/>
    <dbReference type="KEGG" id="loi:92363859"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000195">
        <property type="entry name" value="Hypothetical_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5487604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="22328" checksum="4379534837FF2860" modified="2021-09-29" version="1">MADEGAMDIRLVLKGPNGEFKVDRDLYVIVHCDDGKYIEVSKNYTKQCPFIQEDQGDIPEFGYPAAVLEHLIRWAVHYGVEGHAASELARPCIYRDFSYVVTEKWDNDFFNQRLCSPLNQKHYLLTMTAAEQFGMQGLLDFMCIGLGCKLRSKDDNGIIHDVMGLDKETEVTTDDLAEVSKDYPWFDDAVKATTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H9N8</accession>
    <name>A0A836H9N8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome biogenesis regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_01984</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in ribosomal large subunit assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the RRS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061059.1">
        <property type="nucleotide sequence ID" value="XM_067204022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H9N8"/>
    <dbReference type="SMR" id="A0A836H9N8"/>
    <dbReference type="GeneID" id="92357956"/>
    <dbReference type="KEGG" id="loi:92357956"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007023">
        <property type="entry name" value="Ribosom_reg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04939">
        <property type="entry name" value="RRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="140"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="150"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5472663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="216" mass="24932" checksum="B66849E109C0E23E" modified="2021-09-29" version="1">MSEYQLDVGLLTVTDVSTVSGPMRREEDLMSSCMNALKALLGEFVDLPTEVKKSKYESATSLVQLPQPVMSLPREKAPPKPKPLTAWQKFALKKGIDIHRKKANRVFDEDRQEWKDKWGKRAREDREKYDWLREVKPGYMPGEAGGDPFLDDRRTKHARVEKQKKKEEHNKRRSEHLMRAQEEVKHLSAAARNLATASNGKFENAKKFKKSSKRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HA73</accession>
    <name>A0A836HA73_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_02289</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061359.1">
        <property type="nucleotide sequence ID" value="XM_067204322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HA73"/>
    <dbReference type="SMR" id="A0A836HA73"/>
    <dbReference type="GeneID" id="92358256"/>
    <dbReference type="KEGG" id="loi:92358256"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051252">
        <property type="term" value="P:regulation of RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000003">
        <property type="entry name" value="Zinc finger CCCH domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045877">
        <property type="entry name" value="ZFP36-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547">
        <property type="entry name" value="CCCH ZINC FINGER/TIS11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547:SF18">
        <property type="entry name" value="PROTEIN TIS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="94"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5472963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="267" mass="29691" checksum="6E03FD171673847D" modified="2021-09-29" version="1">MTFSVKGGSYSSSHPSPAMHPYISPSLLPQSHGQQAPPSFSLGDEQYVGVPKRVGVDPTKYKTTICRNWEQTGTCSFRGCTFAHGVEELRAPVRPDGHTPVLRPQHISPGNTPPLRASQPPPAPTSSGHYTLEQLLDMLYKEVLHQRELVTVHIEANTTLEAMLRREQVQHDASKKQLEEKTQQCELLARELFARNQQLRKAADSSPEIKGLLDQWETQLASFSDADAKKDDVFYAATATSLTDEGGDSGKEYENARIEELLRALQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HBI2</accession>
    <name>A0A836HBI2_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_04661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000023">
        <property type="protein sequence ID" value="KAG5478428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063089.1">
        <property type="nucleotide sequence ID" value="XM_067206642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HBI2"/>
    <dbReference type="SMR" id="A0A836HBI2"/>
    <dbReference type="GeneID" id="92360576"/>
    <dbReference type="KEGG" id="loi:92360576"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5478428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="347" mass="37410" checksum="C0F7B4269BAA66A3" modified="2021-09-29" version="1">MSWEPGKSRHSEWSHAVDPRKPQSAAPATQSSYSYTREAAQRLEPQSQNLQHARTTEASGASINPAMVAVAQQKARYARFSYATPPALRHSSLRLSSTTNTSGVLDRTQRVDKAHHALTQPAAWSQPLPSACAQHRTTADARSTTRAAANQSTTLYPPPPPPLYELIPPPSEWLQALVSLQERQLLCWQQLTEIQQLMTHHVERLQEEVRCVHEVLAHALGKHSRTEVVVACAANPVKRSRPDGNDRCEAATPTKSVAALPSDNTAATQPNMSAHRARLLGESTASTPAVMQDVPACGDVCRPAALAQRLPSRSTAEPKESNGGEGGAAHSQSTAGAADSEADIFML</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HD11</accession>
    <name>A0A836HD11_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000022">
        <property type="protein sequence ID" value="KAG5479178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063271.1">
        <property type="nucleotide sequence ID" value="XM_067203812.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836HD11"/>
    <dbReference type="GeneID" id="92357746"/>
    <dbReference type="KEGG" id="loi:92357746"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="911"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1455"/>
            <end position="1498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="928"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="973"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="989"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1021"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1457"/>
            <end position="1466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1489"/>
            <end position="1498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5479178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1514" mass="170456" checksum="32E2E3919A9D1DFB" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HDL3</accession>
    <name>A0A836HDL3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_03970</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0220 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061899.1">
        <property type="nucleotide sequence ID" value="XM_067205962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HDL3"/>
    <dbReference type="GeneID" id="92359896"/>
    <dbReference type="KEGG" id="loi:92359896"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007919">
        <property type="entry name" value="UPF0220"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05255">
        <property type="entry name" value="UPF0220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5474793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="114" mass="12600" checksum="E7F708BE202A3498" modified="2021-09-29" version="1">MASKAGLPYNFLMWLPMLVALLGSFVLLLVKPMYILGAEAEMDDDEDVIKKDKSMFFLATLLLFTSICLSVWKTVDPYGNKGVAWPGVALLGHSLLLLLMNCALFIARAQSDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HDW1</accession>
    <name>A0A836HDW1_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_07918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000013">
        <property type="protein sequence ID" value="KAG5484352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064845.1">
        <property type="nucleotide sequence ID" value="XM_067209795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HDW1"/>
    <dbReference type="GeneID" id="92363729"/>
    <dbReference type="KEGG" id="loi:92363729"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="215"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5484352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="332" mass="36098" checksum="CFD679934DCD45E0" modified="2021-09-29" version="1">MLQSPRDQATTSKSALGTSEDAAPRETISVAFAQSQYATPCHDHTIPGSTPGHRLRRLGRRHQPADILYNHLSHALVAHNGGEPWQGNAEHPKPPGGNFVLHTKNGGKRHFDEPTGFVSERLWKPSKRVIVPPNEQERPHTANRRGRGVYNTSDGWIHPDAEEALRRREEEALRQHARSRKAQVAGPPNHTLEELSMWIRTRTGTDAGAAGPSEAHTATSAATATAANGGRGKRHLLPRHKASAPVISAVAPITEPPPPKVLADYSDILMLPAIGQGMSLQHSRAAEAESLAQSHRDKRVRQMLQAARAATAASSTRAADIQAVRELPNWLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HG07</accession>
    <name>A0A836HG07_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_05130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062403.1">
        <property type="nucleotide sequence ID" value="XM_067207100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HG07"/>
    <dbReference type="GeneID" id="92361034"/>
    <dbReference type="KEGG" id="loi:92361034"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5476170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="93" mass="9918" checksum="8EE868F3B6CF730F" modified="2021-09-29" version="1">MPFVGLDEQLRLRRVELHLLISGGVAQGVEGAPCPRLHAGSDAATASCACSATRQCWRPLPHAAPQHPRPLAPLQAVAVETVCAYATWPLTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HG85</accession>
    <name>A0A836HG85_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_05163</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062436.1">
        <property type="nucleotide sequence ID" value="XM_067207133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HG85"/>
    <dbReference type="SMR" id="A0A836HG85"/>
    <dbReference type="GeneID" id="92361067"/>
    <dbReference type="KEGG" id="loi:92361067"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12084">
        <property type="entry name" value="DD_RII_PKA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5476203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="68" mass="7861" checksum="936BD9C10BC91882" modified="2021-09-29" version="1">MNQYDEIMEADKVYLEKVGMQDVLQQFVADTMETHPDNIYEYMMTWATRRRTPSVALPKGADVNCDVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HGD7</accession>
    <name>A0A836HGD7_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_04575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062767.1">
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    </dbReference>
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    <dbReference type="SMR" id="A0A836HGD7"/>
    <dbReference type="GeneID" id="92360492"/>
    <dbReference type="KEGG" id="loi:92360492"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5477356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="251" mass="27413" checksum="6B4F16EC70570BA7" modified="2021-09-29" version="1">MEVDQHIAATISEIDRTLRFLGIRDEYSRTLPQSSIVSSPPAFMSAMVARTDGTAQTSSSSRLSSGVQKSCSTASQGMQHSPQQRTTSCQTEKGTNTQEHLAKLATSVRCTYAILEEKFQALESSAGKIEALFVKLARTKGKASSSATTFHLLQNRWSMVIIEKEEMSARSAVLSAESDARTQLTSLRCGELVRLVAAFTKEEVQSKPSSELKRVVQTPVMANAKARKGTASSSLDDLTELLDECWRVLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HGJ4</accession>
    <name>A0A836HGJ4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA/rRNA methyltransferase SpoU type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_04887</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000014">
        <property type="protein sequence ID" value="KAG5483735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064674.1">
        <property type="nucleotide sequence ID" value="XM_067206865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HGJ4"/>
    <dbReference type="GeneID" id="92360799"/>
    <dbReference type="KEGG" id="loi:92360799"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002128">
        <property type="term" value="P:tRNA nucleoside ribose methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004384">
        <property type="entry name" value="RNA_MeTrfase_TrmJ/LasT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42786">
        <property type="entry name" value="TRNA/RRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42786:SF6">
        <property type="entry name" value="TRNA_RRNA METHYLTRANSFERASE SPOU TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="38"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="158"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="279"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5483735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="531" mass="56898" checksum="C745602AC6638A78" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HGZ0</accession>
    <name>A0A836HGZ0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mon2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_06738</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000009">
        <property type="protein sequence ID" value="KAG5486032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065363.1">
        <property type="nucleotide sequence ID" value="XM_067208652.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92362586"/>
    <dbReference type="KEGG" id="loi:92362586"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032817">
        <property type="entry name" value="Mon2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16206">
        <property type="entry name" value="Mon2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mon2 C-terminal" evidence="2">
        <location>
            <begin position="2040"/>
            <end position="2184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1250"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1593"/>
            <end position="1613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1942"/>
            <end position="1968"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2845"/>
            <end position="2866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3000"/>
            <end position="3029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="873"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1252"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1281"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1317"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1942"/>
            <end position="1951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1952"/>
            <end position="1968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="3008"/>
            <end position="3020"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5486032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="3029" mass="316295" checksum="F6FB425BA608DE6C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HIF9</accession>
    <name>A0A836HIF9_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_06277</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000007">
        <property type="protein sequence ID" value="KAG5486812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065606.1">
        <property type="nucleotide sequence ID" value="XM_067208201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HIF9"/>
    <dbReference type="GeneID" id="92362135"/>
    <dbReference type="KEGG" id="loi:92362135"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5486812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="253" mass="26746" checksum="B99430B835D09E10" modified="2021-09-29" version="1">MLSVSVSTDEEDTLREFVDPDARRCACSDDTESCCRLTAAEELRGHLLDCFSLYGCRFEHSAVTLACIQPLLRSSSSSARHGSAPRISSVVEAEEKELCSAGSAFDVSTVATVLFVHAGATSGAFGGAAGERDSGGTVSLFGVVVSFHYWRGFRCVAECRYSSAAEAQGEAEALESAHLTVSEVLKTPPWRLIGEPVAEESSSATPSNIHADLPTTLGSTDMAPRFAGGERNTAAARGDAYESLMALMVSIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HKM0</accession>
    <name>A0A836HKM0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DnaJ protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_07293</name>
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    <organism evidence="9 10">
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                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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        </source>
    </evidence>
    <sequence length="454" mass="48765" checksum="AC4EFDE56B459E42" modified="2021-09-29" version="1">MGNCCGSASAACTVAQCSSDFSLPPPPPHRRWSDSTSSSTEKEKATLKKRGRLASTSLTVSAVLALREDGDVGSSSFHSTVGDAAASAARRTHSNVAAFAAPMHTPAVPVTAKPQHGANGSGPGLPMADLFHISASSLSALLTNGDINDNAEDGVCTFGDGEGQSSVVEVSPPTQSVKGDAHTCSEMDMASEWDPPSFERLGRRPERRGRCGLDRIRLRHLIISESEARASLAAIYTHERQRLLLQFAQEWFIAVHISMWRGYESKWAAQCIYWIMAVERVTREEVERMWLIERATLMHRAKPFWAPPLSARELTMLDTAASYGVKREKSLPPVSNSVTAADLTSSEEAADDDTSNMCSPSIRAFSTLALSTLSELPHKQQLSALSGSRLATDGKSKVPRSASRGSTRRALSSVSSPASPLYSPLQLKRLTPAQQALHDKLAQGRCIAATGAHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HN24</accession>
    <name>A0A836HN24_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063526.1">
        <property type="nucleotide sequence ID" value="XM_067207753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HN24"/>
    <dbReference type="GeneID" id="92361687"/>
    <dbReference type="KEGG" id="loi:92361687"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5479815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="424" mass="45653" checksum="C29E6EC23BBD62A8" modified="2021-09-29" version="1">MLNMWRWRALPWRRYRTSASQETWPVPITRCGRRRHGTVADSRCTGAASASAAHCTHPCPTSSPCSAQAPSFHRCPTAAVLVDASGSALITLPYCMTDVQEEVRVHLRRLLAQRLIAPLVTESLADLFGAQDSEGGSNTHADRSGDIVAMASAVVHSVTRSPSTLRYLVFSHENPRLRHPSWAPLWAPSPSLSIPSTVPCSSPAKPQATIHAGNKRPDEAVAEALDVRVTVVEKDAAEALVRPCLGEVVPLLGRQTCGSFLAVTATASGTLSATRSHSTKASTPTVTSAVPPPSPLPSLPVVAYWERCRVDSFIPSYVQVQAAVRHLLLRRRPTEGVTERAPSSAPAAFASVPQPPPARPLALVAVVAPDHLTELYSDFVDMLEREARQRSHEQHQQQRGATSGGPVQLLLFNSKGLAREHTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HNG7</accession>
    <name>A0A836HNG7_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063529.1">
        <property type="nucleotide sequence ID" value="XM_067207756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HNG7"/>
    <dbReference type="SMR" id="A0A836HNG7"/>
    <dbReference type="GeneID" id="92361690"/>
    <dbReference type="KEGG" id="loi:92361690"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5479818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="328" mass="35870" checksum="A24F515265D62CAF" modified="2021-09-29" version="1">MASSPESPLHMLLGALEKKYPQYQSKLAQVQKIAGEASKVLDRAWPYFTMATRYVSVAMEQATRYKLDEFGPMLLGLALCFFGGAYTMLIAVVETVRLLCWEDLKRALQVLHHNYELAAEQDQKDNRGDAEAQGMGNAELLPRRIAVFLRSVDIETAQTACRTIAAAAMSVIAALRVKLARSLALGGSLASMAMDYVPLEATLKDMLPAEHKKWAGVLSKIVANTITMTLASMLSGAIGMVHCCIRGAHLFVEHTVHIAKDHGLLEDDTTLESPKAKALVAVVASVGLLWQVTHTEAYPFPINFFLLPFTVAEYLLFFAVNGVLFAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HRP9</accession>
    <name>A0A836HRP9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_07191</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="JAFHLR010000015">
        <property type="protein sequence ID" value="KAG5482981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064477.1">
        <property type="nucleotide sequence ID" value="XM_067209094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HRP9"/>
    <dbReference type="SMR" id="A0A836HRP9"/>
    <dbReference type="GeneID" id="92363028"/>
    <dbReference type="KEGG" id="loi:92363028"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000104">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF396">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="2">
        <location>
            <begin position="169"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5482981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="374" mass="42390" checksum="8309F9B4A16364FF" modified="2021-09-29" version="1">MAHTKRGRPNVDLSLCTLSSLPTDTLSVEKENDVLFRLLELLPERYTSKIAEEQRIPEGLIVQILVKARAIIASEPMLVEVNSPVYACGDLHGQYYDLINIFKRCPPLGGTVFGTDAKRARKEASSSIDDKTYSFLFLGDYVDRGARSVEVVVTLLALKIISPRHMTMLRGNHEDEQIMLLYGFYDECKRRYSIKLFKMFTDFFRVLPVAALVNGSIFCVHGGLSSELRHARDIPDTRPCNVPHSGIICDLLWADPEADLPPGVDWAPSSRRISSVFSERALERFLVDNDIDLVCRAHQVVEEGFQFFPDHKRRHLLTIFSATNYCNEFGNRGGILCVDERGVCSIITLEPPDFVQQRDIMLFRDPLPNPLNRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836I1U1</accession>
    <name>A0A836I1U1_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_06270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG5486805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5486805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="135" mass="15207" checksum="CE5328B6EFA17FE9" modified="2021-09-29" version="1">MWKTGERQGCHVALFSKPIRMSGHSLLGRRCLDQQSGRQLWDGQAGLDRSSEKNASTQIQKLAHRHAHAEAGNARRGQRLHLSERSMSCPSNYWDNALQQLFQRRIGASRPLLDGAVSQQRRTFTMSGANGPRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836I5H1</accession>
    <name>A0A836I5H1_9TRYP</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name evidence="2" type="ORF">LSCM4_08355</name>
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    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Leishmania</taxon>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000001">
        <property type="protein sequence ID" value="KAG5488278.1"/>
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            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="305"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="277"/>
            <end position="291"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="381"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5488278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1018" mass="105506" checksum="D71ACB966F50992B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836K6P9</accession>
    <name>A0A836K6P9_9TRYP</name>
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        <recommendedName>
            <fullName evidence="3">L-seryl-tRNA(Sec) kinase</fullName>
        </recommendedName>
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        <name evidence="1" type="ORF">LSCM4_00591</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Euglenozoa</taxon>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="PANTHER" id="PTHR20873">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20873:SF0">
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5465139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="459" mass="50868" checksum="BAECA18EA67A6CFE" modified="2021-09-29" version="1">MMTAPLSPLSRHPSALLFLVTGLPASGKSTFLAAAQLHVLECDSTAGKVPLFGGRCHGRISSVLQLDQVLADLEKSTVHNKDLPSSAGERKFSPLLWRRATRRLLELAQSALLTSVAGTADGDATQDAVIPMVFVEDNMHYRSMRERYYQMCRTLERGEHSEGAPRDIPAATAQSQRPYIVLFELRFVTPLVVCLARNAQRGSPQKVSGNEQGQESAWVPPPVICSMDALFDHCYAAADRMDQTAGALSDSKVWQWTATTQPWGLLVHGTRSVLEDNLPAAPRETAAAFFDVALQQPEAWEVCQRQCQDTARSRLQRLREEEHLSAIISLRRAAEAVESHVHQLDLQLRRVVHAFLRQRYHRPAHDAENAPPSLQQAALFHKSIAAAKQEAAHSFKVQLRQLSTAKKEVTSTTAAGLLIGSIDDVQESVLQQFQHRVLELWREFEECALTVSHTASATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836K957</accession>
    <name>A0A836K957_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">LSCM4_00970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059686.1">
        <property type="nucleotide sequence ID" value="XM_067203036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836K957"/>
    <dbReference type="GeneID" id="92356970"/>
    <dbReference type="KEGG" id="loi:92356970"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5467884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="187" mass="20920" checksum="986F7F36FCA5423C" modified="2021-09-29" version="1">MPFRIEKQSPRNSSFAAPGESYLILASSASLRKHLTDSYWCEAMEQVCFGKLEGVAVRYTGDNLVMVQFRPTSLSPAGYRYPLFMSIPIEFLVPVAESIFNIPVTSDMQGSFGTVTTSSVHSRSSSEDRSSHAAALPRLCVVCGRYNLPGMVRRLHGWKCKECKGTKSDNRLRLEAEKLRKRLRAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836K959</accession>
    <name>A0A836K959_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Succinate-semialdehyde dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="3">1.2.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">NAD(+)-dependent succinic semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_00177</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; 4-aminobutanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.24" evidence="3"/>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058367.1">
        <property type="nucleotide sequence ID" value="XM_067202266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836K959"/>
    <dbReference type="SMR" id="A0A836K959"/>
    <dbReference type="GeneID" id="92356200"/>
    <dbReference type="KEGG" id="loi:92356200"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07103">
        <property type="entry name" value="ALDH_F5_SSADH_GabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000004">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000005">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF5">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="43"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5464736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="509" mass="54982" checksum="D60CA993DDB241F8" modified="2021-09-29" version="1">MSKLLRTVGAKGWMPFDWANAAQYASGTAPMMKEPACYIDGAWVTSALSAKTVDVEDPCTNQIIGAIPCMGNAETMAAIEAAKAAFESWKQVMPPRRAAVVRRWGELIHQHRDVIGNILSRESGKVIAEGNGEVLYAKEYAEWYAGEAERIYGDIIPSLRHGVQATVFREPVGVVGIITPWNFPAAMITRAACGAIAAGCTVVLKPAELTPFTAMALAQLAEEAGIPPGVFNVVAGDARKVGDALVESFDVRKISFTGSTRVGKELYRRCAETMKRVGMELGGNAPFIVFEDADLPRAADQLIAAKFRNAGQTCICVNRALVQASVYKEFKSLVAERVRALKVGNSFDPSVKVGAVIGSTTLKRMTRVVEDAVEKGATVMVGGKALEGRGYFFEPTLLTDVPHDTALCWQEELFGPVLPLAPFDTEENVVRMANATRAGLASYFFTNDHRRQHRVARALRYGMVGVNDSALSSPRAPFGGVKESGLGRDGSKYGIDAFVDIKYVLFSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KA97</accession>
    <name>A0A836KA97_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_01258</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059006.1">
        <property type="nucleotide sequence ID" value="XM_067203315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KA97"/>
    <dbReference type="GeneID" id="92357249"/>
    <dbReference type="KEGG" id="loi:92357249"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5466116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="439" mass="47415" checksum="2B53FA87791A5B87" modified="2021-09-29" version="1">MEITHIIAVVFCNRAALQYALWAALLFAPLYAFALKPLVRWCRRCAAMKAAAVAVARTASPPPAASTPYETPAQVSSASSKGYLSPVPVGAAPAPFVPIFATSATAASTSKALSRSSNASMSHRSSIGTQLSPLVPHDSTPRRQGSACSLEVKGTALTLEVEYRSPTQRFVAALRRLVQQRSAALFNIGDSALRSALQSGEVYLHRHASLQLPSQDYLAQRFLYRQRLQEQYDKLNTTDASLEELYSRPAFQEWYAANREQLLRDVRLRESFAKWHSVATAFVLVVALMLLPAYSFSMQTDAMQWISPLASAEDEAAVAAAPLVQLLTTRLYYIQSRGSTRQVRTSAAPFTFRGRADARAMATTAVKAAEYVSVVAAACALVTSCFMPRESGTTATVALVSFLLLVTESALVPAAAVKLGLGFLVVFAIVSMSIYRAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KCR9</accession>
    <name>A0A836KCR9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_03122</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">LSCM4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060691.1">
        <property type="nucleotide sequence ID" value="XM_067205139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KCR9"/>
    <dbReference type="GeneID" id="92359073"/>
    <dbReference type="KEGG" id="loi:92359073"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF301">
        <property type="entry name" value="ACID TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="6">
        <location>
            <begin position="64"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5471574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="459" mass="50523" checksum="7E9EC9DE955D5FC4" modified="2021-09-29" version="1">MKDAKGADGVSSADAADPYDFSRYDPKHNIEAQDKIRADRVARRLVPTNVFQKYFDYLVPYGGLMSTGLNLASSSIGAGIIALPYAFNSSGLIMAIIYMVIIAYLTIYSYYLLGQVGTRTGLRNYEQIVRTLLGPGADYFLAFCMWFLSFGGEVSYVISVKDVLTAFLEDADSTPEFLLNIWGQRLLTFIVWLVAMLPPCLPKEINTLRYFSCIAIVFIVYFVIAMVVHSAQNGLRADPRPEIRMFTTGNTAISGLTTFMFAFLSQLNAYESYEEMKSPTPLRLTLGASIAVGIVFVLYFFAGLFGYLDFGAAMTGSALKQYTPVKDVMMGVGYAGILFKLCVGFGLHMIPIRNAIYHCVGADVHTIAWWKNACVCGFMAFLALVAGLFIPNIKVVFGLVGGFSGGFIGFIYPSFMVMYAGDWSLSSVGWYHYLSTYFLLIVGVIGVVWGTASSIYGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KCT4</accession>
    <name>A0A836KCT4_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058990.1">
        <property type="nucleotide sequence ID" value="XM_067203299.1"/>
    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
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            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
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                <person name="Gatherer D."/>
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            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL31 family.</text>
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    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    <sequence length="188" mass="21346" checksum="911EB13490124A99" modified="2021-09-29" version="1">MTRAGMKGKVLGKEKKSAIIDARKKAVESRRSRDDKRWKRVIAKMDEEKRKKFHGVGNTAKNSRVRGATRASLRKRTGRKPDAVSMEATIHLSKLLKKKTFAKRAPLAIKRIKAFVGRLMKTKDNRIDASLNTYIWHKGVKGVPGRVRVLIQRKSETTEGNKHKHFYTVISNVPVASFKGLTTKTVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836KD48_9TRYP</name>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067203644.1"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A836KD48"/>
    <dbReference type="GeneID" id="92357578"/>
    <dbReference type="KEGG" id="loi:92357578"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="KAG5466445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="604" mass="73031" checksum="D21AA9FB0BDE40DA" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KG94</accession>
    <name>A0A836KG94_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">LSCM4_03188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG5471637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneID" id="92359136"/>
    <dbReference type="KEGG" id="loi:92359136"/>
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        <property type="component" value="Chromosome 31"/>
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            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="343"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="638"/>
            <end position="660"/>
        </location>
    </feature>
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        <location>
            <begin position="720"/>
            <end position="760"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5471637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="949" mass="103444" checksum="00C5F3557075EEB8" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KGL5</accession>
    <name>A0A836KGL5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methyltransferase</fullName>
            <ecNumber evidence="6">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_00254</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4 5 6">Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058444.1">
        <property type="nucleotide sequence ID" value="XM_067202343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KGL5"/>
    <dbReference type="SMR" id="A0A836KGL5"/>
    <dbReference type="GeneID" id="92356277"/>
    <dbReference type="KEGG" id="loi:92356277"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003838">
        <property type="term" value="F:sterol 24-C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000334">
        <property type="entry name" value="Methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050447">
        <property type="entry name" value="Erg6_SMT_methyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030384">
        <property type="entry name" value="MeTrfase_SMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013705">
        <property type="entry name" value="Sterol_MeTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068:SF1">
        <property type="entry name" value="HYPOTHETICAL LOC100005854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068">
        <property type="entry name" value="ZGC:194242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08498">
        <property type="entry name" value="Sterol_MT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51685">
        <property type="entry name" value="SAM_MT_ERG6_SMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase Erg6/SMT-type" evidence="7">
        <location>
            <begin position="56"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5464813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="353" mass="40212" checksum="6F9356EC28CBB9E3" modified="2021-09-29" version="1">MSAGAREIAPTNLIRRRNKGETNEDVSAAADRFRERFEKASLEERKAATTTMVNEYYDLVTDFYEYGWGQNFHFAPRYAGETFYESIARHEYFLAARGGFKEGDQIVDIGCGVGGPARNIVRLTRCNVTGVNNNDYQISRARRHDARAGMSSKIDYVKTDFCNMCLDDNTFDGAYAIEATCHAKDKVKCYSEVFRVIKPGSCFVLYEWCMTDKYNPDDEYHRKIKHRIELGDGLPEMETYKQVIKYVKQAGFVVEESVDVIEQFESSSIKSIPWYQPLLGSYSSLQGLRSTPMGRIFTNVMCRVLEFLHLAPRGTHKTTEILEEAAKGLVIGGQLGIFTPSFYIRARKPLKQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KIK6</accession>
    <name>A0A836KIK6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_04432</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062625.1">
        <property type="nucleotide sequence ID" value="XM_067206416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KIK6"/>
    <dbReference type="GeneID" id="92360350"/>
    <dbReference type="KEGG" id="loi:92360350"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="22"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5477214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="424" mass="47047" checksum="DD699CBE73D635ED" modified="2021-09-29" version="1">MLCPTDAARPRGVKRAMPAPEPPLCEGWLEKFALCRGMFSKKGWHHRYAFITHEGLGLSHRNPRDKGNCLPGHPLEMSHAQSFIPFSKKRNGEIEIQPVYFVDNVSAARHPEVPKKSYNGICSESMSVTEGGSNGASACTPARTASATSGNNCTYYYFGLTFEEHRKRYLLLLRTSSPQEYIKWTTYLPLYVHEGSASRIVPLGHPLEAGRPQPIDLNHRRLTENRESTLPSPVTFYIDPDPCSLNEYFKVRRLCLDWDEGERGRLFTTAVERVRSLCGKSESDASGSIAGMQDQSEEEYRNAVSSLFEELSPALPDCDEEYTLNSRKDAPESCSTAISSVEKDAGSFGAAQQPSKDLDPSDGADSRPKVAKNSKKPISRHLRPKTLRKAGGLPRMGTTRRHPRPVKCGTTTYAGPSRKRGTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KJ60</accession>
    <name>A0A836KJ60_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome c oxidase subunit V</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_05156</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062429.1">
        <property type="nucleotide sequence ID" value="XM_067207126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KJ60"/>
    <dbReference type="GeneID" id="92361060"/>
    <dbReference type="KEGG" id="loi:92361060"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5476196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="22261" checksum="2B45BF95D9357060" modified="2021-09-29" version="1">MKRFCSPTLAVVSSIRTFFGKGWDNAALDTIYSSMLRKPEVNDRIRTQYASTMDPRDADVLRRLGEVSKENKTFIRVFLPPHLGDPHRLLKCYSLMAYPILDDKGGQLKVEMDGHKLDAFADPDDDYSKVVIPHIELVEYLAKSLLETMKWEATPRGAASLLESLYRGAEIPDHVFQTPAVIERLENYKDGNKVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KJJ7</accession>
    <name>A0A836KJJ7_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_01126</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5468038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059840.1">
        <property type="nucleotide sequence ID" value="XM_067203190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KJJ7"/>
    <dbReference type="SMR" id="A0A836KJJ7"/>
    <dbReference type="GeneID" id="92357124"/>
    <dbReference type="KEGG" id="loi:92357124"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="80"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="240"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5468038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="270" mass="30150" checksum="788BC02FA0FC5DC5" modified="2021-09-29" version="1">MLSARVQRSDGACEAPFPDTARDPPPLRSTSRSEVMGTPCNAKQRHHEVQPHLDAIQRELGELRRRRQQLEAQRKELLEGMHDPAEGHRPGCNSSSVSTHAGPARSHSTPGLTFAHPRSEVESLTTYSRLRANGEHRCRTAYPEAFALAYLTPIPSEQERRRMLKATPHLSVKNALRVAAQQDSTLLMGDFLPEDNPHACTFGRERRFRPLLGQKGKYFLSADFAIDQCIHRSHADSTKSLIGLGNTSQTPGPGTYTPRYSKLSRPPRAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836KJZ0_9TRYP</name>
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        <recommendedName>
            <fullName evidence="4">ICAM-L protein</fullName>
        </recommendedName>
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        <name evidence="2" type="ORF">LSCM4_04286</name>
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    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475702.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067206273.1"/>
    </dbReference>
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    </dbReference>
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        <location>
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            <end position="115"/>
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        <location>
            <begin position="212"/>
            <end position="237"/>
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    </feature>
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        <location>
            <begin position="308"/>
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        </location>
    </feature>
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            <begin position="356"/>
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        </location>
    </feature>
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            <begin position="94"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5475702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="382" mass="39878" checksum="F6E2FC70420DB68C" modified="2021-09-29" version="1">MTQQREGKAGPSNSTTAVAAASVPDPALFFSLGPASFTDAIAVTKVVSVVLPLRHLRDRNLLHTTLLRKLLHRPYEPSAEDLAQQQLSQPEADDGCKYEHGASTSLDDHATSTSSSSSLAPYVIVHIKSAEVHSDTARQVNPRGDVQVNVMVTLVAARLQHGICAGVSEASPFALCMQVRVPTVAVPAAVAARENTDDAAVLLLGVAPTTGTDSVLHEEDKDEEAEPSNSDAAVNASAPSVAAVAAKHKCRTGVPEDQQLRVTARCLEDEPIVPGQAVLLVSEPAAMRCIGIRPPRAAPGAFFFTEEARPPVQSSSGATEDGPESAPKKRARKSRALAGGADGANAARRVVAIECAIPKREEDGEGGAAAGSRKGSRKRPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KK71</accession>
    <name>A0A836KK71_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Euglenozoa</taxon>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061633.1">
        <property type="nucleotide sequence ID" value="XM_067205696.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="92359630"/>
    <dbReference type="KEGG" id="loi:92359630"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029358">
        <property type="entry name" value="CFAP96"/>
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        <property type="entry name" value="CILIA-AND FLAGELLA-ASSOCIATED PROTEIN 96"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UPF0602 PROTEIN C4ORF47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15239">
        <property type="entry name" value="CFAP96-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="168"/>
        </location>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="21"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5473630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="341" mass="37866" checksum="6EC04ABF3E727A0D" modified="2021-09-29" version="1">MTDTSAYGGLFQDPPYLSSDPDPRKTDPYEKYDAIPSRYLGKSMTVGGRVPPGQHPEAYFDKKFLTLASSEQNGGKPVDYDESKWSTAAAKTKSQKPISDKEFRYSSYPEKSTGPGSYYGCFQSRPYEYMTEPWSDGKSKKKRAAKPKEEEKPTHLPNIKTNPAKKGTYGYPGLLLSNPTYNDNWKSDYAAAEADRARRERKQGLAATALGPPFHIPGVSHSYIDEMPNTGVSGVYAAYEAPADSAAEKRKAKKEAAAAPSLVQERAFCGSANRSGEQGCLNPFPNVWVHPDQTQPSKSAQRKQAQKEKEEAARQLKRVAVWKPNSFEKTSVVSSCLRRFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KKJ3</accession>
    <name>A0A836KKJ3_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">LSCM4_02469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060050.1">
        <property type="nucleotide sequence ID" value="XM_067204498.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="loi:92358432"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="549"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5469073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="623" mass="67628" checksum="8402BDC0B2823CB6" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KM46</accession>
    <name>A0A836KM46_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCAAT-binding factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_04222</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062148.1">
        <property type="nucleotide sequence ID" value="XM_067206211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KM46"/>
    <dbReference type="SMR" id="A0A836KM46"/>
    <dbReference type="GeneID" id="92360145"/>
    <dbReference type="KEGG" id="loi:92360145"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12048:SF0">
        <property type="entry name" value="CCAAT_ENHANCER-BINDING PROTEIN ZETA"/>
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    </dbReference>
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        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <begin position="349"/>
            <end position="520"/>
        </location>
    </feature>
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        <location>
            <begin position="659"/>
            <end position="839"/>
        </location>
    </feature>
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            <begin position="672"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="704"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="779"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="828"/>
            <end position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5475640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="839" mass="92184" checksum="D67F25816E3DD47C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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        </lineage>
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        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
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                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">LSCM4</strain>
        </source>
    </reference>
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        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000020">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:nuclear receptor activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
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        <property type="project" value="InterPro"/>
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        </location>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KPL5</accession>
    <name>A0A836KPL5_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06384</name>
        <name evidence="3" type="ORF">LSCM4_06385</name>
        <name evidence="4" type="ORF">LSCM4_06386</name>
    </gene>
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        <lineage>
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            <taxon>Trypanosomatida</taxon>
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    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">LSCM4</strain>
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    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG5480816.1"/>
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    </dbReference>
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    <dbReference type="KEGG" id="loi:92362239"/>
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        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5480817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5480818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="161" mass="17482" checksum="D2105979A3CB2A60" modified="2021-09-29" version="1">MSATRSLSLPFGYPRSILNVSLSPHRLSFSFLRSRAVTASRLLHAFQTLRSSTPTPNPPRRHGLSTSCCPQVLCGAQVAPQAEALVERVREPLSEGDQQPHVDVWPHDEDCELVRERRDGAHCDGSRVDCSRAQEAHAGRARGADGGAPCAAARAREARHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KPT2</accession>
    <name>A0A836KPT2_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">LSCM4_05601</name>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000016">
        <property type="protein sequence ID" value="KAG5482346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064352.1">
        <property type="nucleotide sequence ID" value="XM_067207538.1"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A836KPT2"/>
    <dbReference type="GeneID" id="92361472"/>
    <dbReference type="KEGG" id="loi:92361472"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="440"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="97"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="157"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="327"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="440"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="454"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="479"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5482346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="628" mass="71114" checksum="547215EB022A193A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KQD6</accession>
    <name>A0A836KQD6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amastin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_04876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000014">
        <property type="protein sequence ID" value="KAG5483724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064663.1">
        <property type="nucleotide sequence ID" value="XM_067206854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KQD6"/>
    <dbReference type="GeneID" id="92360788"/>
    <dbReference type="KEGG" id="loi:92360788"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5483724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="35045" checksum="347A2AEA749551BA" modified="2021-09-29" version="1">MLNDSHAAREPLTEISSLRTSRRPSMLLRKSKIGGRTLLFIPYRERVLIALAAVMQVSSLRTSRRPSMLLRKSKIGGRTLFIPYRERVLIALAAVMQVIILVLLIAAATTDVFKVDGTRAIEIGVDLRAVSDGLGVTVTEGSKPFCYSLWGAHKCGSASFYSENWYTEHNISHKGFPSPVTHTMILGSAAFAVLAACYSLINIVGIVTVVCMQDYTAVLCAWSFSVWITILISWALSVGVYARTMTTVNSTTIVGRKVRVKDYCDFSSSFALTMTAFALHALQFTFTVLYTRLFEKRVKSLVTEQKRLNEEHLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KQZ5</accession>
    <name>A0A836KQZ5_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_07860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000013">
        <property type="protein sequence ID" value="KAG5484294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064787.1">
        <property type="nucleotide sequence ID" value="XM_067209737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KQZ5"/>
    <dbReference type="GeneID" id="92363671"/>
    <dbReference type="KEGG" id="loi:92363671"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5484294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="239" mass="26279" checksum="F3B36638594298C0" modified="2021-09-29" version="1">MVPRVSYVDSLLSSGNTVGCASIVGHDGTVASVREVRESVVVWTASHEEPRGPTNMPQAVEATEGGGSSLSNIVRYVRHRSMAIDFRSRPKSKKGSSMQTTSPADAAIRVDATEDGDLFQSSREPFDNNIDCAGSESMDDAEAELYVNRRSAGSENCTSQLRDKQSMTPFGFYHFLWHPRGKYMCAQDPVSAIALLTDRSGMRIQLRDHLMSAYTKGFMEYIYSASPVHRCPPPSKRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KR41</accession>
    <name>A0A836KR41_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Squalene monooxygenase</fullName>
            <ecNumber evidence="4 9">1.14.14.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_07996</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">LSCM4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>squalene + reduced [NADPH--hemoprotein reductase] + O2 = (S)-2,3-epoxysqualene + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25282"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:15441"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="1.14.14.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the squalene monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.17" evidence="4 9"/>
    <dbReference type="EMBL" id="JAFHLR010000013">
        <property type="protein sequence ID" value="KAG5484429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064922.1">
        <property type="nucleotide sequence ID" value="XM_067209872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KR41"/>
    <dbReference type="SMR" id="A0A836KR41"/>
    <dbReference type="GeneID" id="92363806"/>
    <dbReference type="KEGG" id="loi:92363806"/>
    <dbReference type="UniPathway" id="UPA00767">
        <property type="reaction ID" value="UER00752"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004506">
        <property type="term" value="F:squalene monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013698">
        <property type="entry name" value="Squalene_epoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040125">
        <property type="entry name" value="Squalene_monox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10835">
        <property type="entry name" value="SQUALENE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10835:SF0">
        <property type="entry name" value="SQUALENE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08491">
        <property type="entry name" value="SE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0274">FAD</keyword>
    <keyword evidence="5 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Squalene epoxidase" evidence="10">
        <location>
            <begin position="210"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5484429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="569" mass="63836" checksum="BAB99A4FE34C67B4" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KST1</accession>
    <name>A0A836KST1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Inosine/uridine-preferring nucleoside hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_07157</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IUNH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000018">
        <property type="protein sequence ID" value="KAG5481445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064124.1">
        <property type="nucleotide sequence ID" value="XM_067209061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KST1"/>
    <dbReference type="SMR" id="A0A836KST1"/>
    <dbReference type="GeneID" id="92362995"/>
    <dbReference type="KEGG" id="loi:92362995"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008477">
        <property type="term" value="F:purine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045437">
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        </source>
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        </source>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">UTP23 sensor motif region domain-containing protein</fullName>
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        <name evidence="3" type="ORF">LSCM4_07639</name>
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            <taxon>Leishmania</taxon>
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    </organism>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000012">
        <property type="protein sequence ID" value="KAG5484867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067209519.1"/>
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    <dbReference type="GeneID" id="92363453"/>
    <dbReference type="KEGG" id="loi:92363453"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="UTP23_sensor"/>
    </dbReference>
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    </dbReference>
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            <end position="634"/>
        </location>
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        <location>
            <begin position="212"/>
            <end position="238"/>
        </location>
    </feature>
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            <end position="233"/>
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            <dbReference type="Pfam" id="PF24779"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5484867.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836KTK5_9TRYP</name>
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        <recommendedName>
            <fullName evidence="2">VWFA domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="3" type="ORF">LSCM4_07418</name>
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    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000008">
        <property type="protein sequence ID" value="KAG5486486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067209309.1"/>
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    <dbReference type="KEGG" id="loi:92363243"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="3"/>
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            <end position="94"/>
        </location>
    </feature>
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    </feature>
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        <location>
            <begin position="2216"/>
            <end position="2227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5486486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="2565" mass="276815" checksum="00A32774ED014FAB" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KUU4</accession>
    <name>A0A836KUU4_9TRYP</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_07530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000004">
        <property type="protein sequence ID" value="KAG5487851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067209416.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="92363350"/>
    <dbReference type="KEGG" id="loi:92363350"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="194"/>
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                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
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                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Bates M.D."/>
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</entry>
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                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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                <person name="Al-Salem W.S."/>
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            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
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                <person name="Gatherer D."/>
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            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="protein sequence ID" value="KAG5467727.1"/>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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        <property type="entry name" value="POC1 CENTRIOLAR PROTEIN HOMOLOG"/>
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    </dbReference>
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    <feature type="repeat" description="WD" evidence="5">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="6">
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        <location>
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        <location>
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        <location>
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        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
            <dbReference type="EMBL" id="KAG5472827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="464" mass="52616" checksum="A65B7BB4870FFA97" modified="2021-09-29" version="1">MHAKVVAPLAASRIQTAHKFPQLRLQPSQHRLITRRRQCNLPLRLFHPSSVEFAKRDLEAGRIVEVRRDDHSLVALGFYEPYLQRVDVFDMTPSLASMLPTISEDSFMARVHEAWERRRRILPQTQSNTYRIVNGYADSLPSLFVDVFSECFVRVVATSFGAERLVPPLLDFLSRRGAEDVLLDTPTLGDAARVSLITPTIPLPQMYVEGGVSHLWLRPDVRMPSTENLFLINPAHRRIRRMLRDLGKGKRVLTIYDRSGSASMNAVMTAKHVTVVHREEASQEWARENLICNHSASVFRACETVCCDPGELRVRHQQDVVYVECHPKFLSTSHQWADLVRSLVINKVVGVGTMLIVAQEEAPLGVRDLLPRRKALYGGDESKADRDRPMTRRPLADVLRNALERCHLQLKFLRAFSVACDHPLLPEAESASFSQLYLLEGPALEQVFRVSPSSSHQKSIDETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">LSCM4_00662</name>
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        <name type="scientific">Leishmania orientalis</name>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="term" value="C:mitochondrial fatty acid beta-oxidation multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:enoyl-CoA hydratase activity"/>
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        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1092" mass="116059" checksum="7BE4C1BF99168389" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G3T5</accession>
    <name>A0A836G3T5_9TRYP</name>
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            <fullName evidence="3">EF-hand domain-containing protein</fullName>
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        <name evidence="1" type="ORF">LSCM4_00255</name>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
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            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="1">DUF1935 domain-containing protein</fullName>
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        <name evidence="2" type="ORF">LSCM4_00777</name>
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    <organism evidence="2 3">
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067202851.1"/>
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        <property type="entry name" value="META domain containing protein"/>
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        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="5"/>
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        <property type="entry name" value="DUF1935"/>
    </dbReference>
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        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
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        <property type="entry name" value="Smp-1-like_sf"/>
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    <dbReference type="PANTHER" id="PTHR47047:SF9">
        <property type="entry name" value="DUF1935 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09149">
        <property type="entry name" value="DUF1935"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101601">
        <property type="entry name" value="Smp-1-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1935" evidence="1">
        <location>
            <begin position="4"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1935" evidence="1">
        <location>
            <begin position="133"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1935" evidence="1">
        <location>
            <begin position="244"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1935" evidence="1">
        <location>
            <begin position="401"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1935" evidence="1">
        <location>
            <begin position="554"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5467699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="665" mass="74407" checksum="EB643D9A1CCB71E1" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G8H5</accession>
    <name>A0A836G8H5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mRNA capping enzyme adenylation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_02810</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:67012"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.7.7.50"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:67013"/>
        </physiologicalReaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060382.1">
        <property type="nucleotide sequence ID" value="XM_067204830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G8H5"/>
    <dbReference type="SMR" id="A0A836G8H5"/>
    <dbReference type="GeneID" id="92358764"/>
    <dbReference type="KEGG" id="loi:92358764"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004484">
        <property type="term" value="F:mRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001339">
        <property type="entry name" value="mRNA_cap_enzyme_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051029">
        <property type="entry name" value="mRNA_Capping_Enz/RNA_Phosphat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367:SF17">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01331">
        <property type="entry name" value="mRNA_cap_enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="mRNA capping enzyme adenylation" evidence="3">
        <location>
            <begin position="805"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="171"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="260"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="458"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="132"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="187"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="220"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="321"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="353"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="518"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00044624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5470116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1112" mass="119241" checksum="F0783BBA625A06A9" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G9B0</accession>
    <name>A0A836G9B0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Dual specificity protein phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_00945</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059661.1">
        <property type="nucleotide sequence ID" value="XM_067203011.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836G9B0"/>
    <dbReference type="GeneID" id="92356945"/>
    <dbReference type="KEGG" id="loi:92356945"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="247"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="605"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="10">
        <location>
            <begin position="1426"/>
            <end position="1566"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="11">
        <location>
            <begin position="1488"/>
            <end position="1548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="643"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5467859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1582" mass="172035" checksum="3B2FA3D64B6B6038" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GCG3</accession>
    <name>A0A836GCG3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_00005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058198.1">
        <property type="nucleotide sequence ID" value="XM_067202097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GCG3"/>
    <dbReference type="SMR" id="A0A836GCG3"/>
    <dbReference type="GeneID" id="92356031"/>
    <dbReference type="KEGG" id="loi:92356031"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="2">
        <location>
            <begin position="180"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5464567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="323" mass="34492" checksum="F60923E1A8DB5CFA" modified="2021-09-29" version="1">MDSVKRRLVYVADESEVLLHELSGTPPARSSRLTRLLVPLSPPTSARESPHSLSPLPRPIGTTAQAASALTADTALLVSYDGFLLTDGNGRFSTPRDATQAASIRDALKTCRAFLKGFLDAARAQSASTESSGSGTSSSTYMEEEDSDLEVSSSDDSPAPRRRAAKAAKAPQPHGPRRSPSHMTVAELKELLRDHGLSVSGNKACLVKRAQTLQRGHESKNVIDTPPVNSDKSGEVLRSSLSDCISLNSGVSLPFPPSSPPLLKMLSPNSHTSEDKNSGIWGALVHAGSRLFRGGGRASWGFRTRSPEDSDDASLSKRRRLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GCV8</accession>
    <name>A0A836GCV8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Topoisomerase 6 subunit A/Spo11 TOPRIM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_00296</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058483.1">
        <property type="nucleotide sequence ID" value="XM_067202382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GCV8"/>
    <dbReference type="GeneID" id="92356316"/>
    <dbReference type="KEGG" id="loi:92356316"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000706">
        <property type="term" value="P:meiotic DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00223">
        <property type="entry name" value="TOPRIM_TopoIIB_SPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002815">
        <property type="entry name" value="Spo11/TopoVI_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036078">
        <property type="entry name" value="Spo11/TopoVI_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034136">
        <property type="entry name" value="TOPRIM_Topo6A/Spo11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848:SF0">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21180">
        <property type="entry name" value="TOP6A-Spo11_Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56726">
        <property type="entry name" value="DNA topoisomerase IV, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Topoisomerase 6 subunit A/Spo11 TOPRIM" evidence="2">
        <location>
            <begin position="299"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="384"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5464852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="544" mass="58672" checksum="8071A64645C616C8" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GDI4</accession>
    <name>A0A836GDI4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase alpha subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_02848</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase alpha subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060420.1">
        <property type="nucleotide sequence ID" value="XM_067204868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GDI4"/>
    <dbReference type="GeneID" id="92358802"/>
    <dbReference type="KEGG" id="loi:92358802"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.60:FF:000013">
        <property type="entry name" value="DNA polymerase alpha/epsilon subunit B, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016722">
        <property type="entry name" value="DNA_pol_alpha_bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061">
        <property type="entry name" value="DNA POLYMERASE 2 ALPHA 70 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061:SF12">
        <property type="entry name" value="DNA POLYMERASE ALPHA SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="7">
        <location>
            <begin position="336"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="541"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5470154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="726" mass="78270" checksum="58804DFEDED7BD53" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GF79</accession>
    <name>A0A836GF79_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059242.1">
        <property type="nucleotide sequence ID" value="XM_067203551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GF79"/>
    <dbReference type="GeneID" id="92357485"/>
    <dbReference type="KEGG" id="loi:92357485"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21450">
        <property type="entry name" value="DLC-like_DYNLL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.740.10:FF:000014">
        <property type="entry name" value="Dynein light chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5466352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="173" mass="19653" checksum="DE220F852000FCE3" modified="2021-09-29" version="1">MAELGTRGDATFDMTSRPGQRCSNAERDRSNSSMLSDMHLTNGFPNGAEGEDEELDVRASQVRMEALYVDVPAKKLQVIMHSALRAYNTHVFIPTRTTWRKEEGSRRELERDVERTALSRIAEDIKKDITAKLGGCWHVIYGHDFATFVTHKRLCFCHFQIEGADVVVWRHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GFP3</accession>
    <name>A0A836GFP3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_02077</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061150.1">
        <property type="nucleotide sequence ID" value="XM_067204113.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92358047"/>
    <dbReference type="KEGG" id="loi:92358047"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001372">
        <property type="entry name" value="eIF-2 alpha kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF189">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="943"/>
            <end position="1684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="147"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="510"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="570"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="641"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="856"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1039"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1097"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1215"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1389"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="161"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="223"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="361"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="594"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="648"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="893"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1039"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1249"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="972"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5472754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1697" mass="181503" checksum="B382B265D69F1F66" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GHQ0</accession>
    <name>A0A836GHQ0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_00938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059654.1">
        <property type="nucleotide sequence ID" value="XM_067203004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GHQ0"/>
    <dbReference type="SMR" id="A0A836GHQ0"/>
    <dbReference type="GeneID" id="92356938"/>
    <dbReference type="KEGG" id="loi:92356938"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000306">
        <property type="entry name" value="Putative ubiquitin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="3"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5467852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="80" mass="8637" checksum="D02205EEC631B0C6" modified="2021-09-29" version="1">MTFSFSVISTTGQRISISVLGPDNTVGDIKAKLEETEGIPQKMIMLVHSGRKLEDNATLEECNIHAGVTINMVLALRAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GIG2</accession>
    <name>A0A836GIG2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LSCM4_02132</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061205.1">
        <property type="nucleotide sequence ID" value="XM_067204168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GIG2"/>
    <dbReference type="SMR" id="A0A836GIG2"/>
    <dbReference type="GeneID" id="92358102"/>
    <dbReference type="KEGG" id="loi:92358102"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001286">
        <property type="entry name" value="Possible serine/threonine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000067">
        <property type="entry name" value="Possible serine/threonine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000867">
        <property type="entry name" value="Possible serine/threonine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006633">
        <property type="entry name" value="Carb-bd_sugar_hydrolysis-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF98">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00722">
        <property type="entry name" value="CASH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="4"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="13">
        <location>
            <begin position="387"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="121"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="423"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="707"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="126"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="432"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="719"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG5472809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="988" mass="106576" checksum="40766F79206E1C99" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GIJ7</accession>
    <name>A0A836GIJ7_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_02194</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061265.1">
        <property type="nucleotide sequence ID" value="XM_067204228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GIJ7"/>
    <dbReference type="SMR" id="A0A836GIJ7"/>
    <dbReference type="GeneID" id="92358162"/>
    <dbReference type="KEGG" id="loi:92358162"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026569">
        <property type="entry name" value="Ribosomal_bL28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L28, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL28M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5472869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="231" mass="26763" checksum="B30BA252D778DC41" modified="2021-09-29" version="1">MLHQSSLWRFSTFALNPETSQAPHGPPRGLINRYISMGLPPWAAWCNRVNRHALYRMSDVSPRSFLPKAPQEMDVIWMNERVRERVRTSRQVQHVYRQLKYPYVKTGIHYSDTLDHWVQVPMVEAAMFAVEKDGGFDNFILRRSGPELRSTYGERIRRHLLVRQKETQKNFVLDQQASALAGVAQAEVMKATNEQELDAVLTKYGMDAEEFKRLMAKRVMEQRKSVAATGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GJA5</accession>
    <name>A0A836GJA5_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061870.1">
        <property type="nucleotide sequence ID" value="XM_067205933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GJA5"/>
    <dbReference type="GeneID" id="92359867"/>
    <dbReference type="KEGG" id="loi:92359867"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029358">
        <property type="entry name" value="CFAP96"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31144:SF8">
        <property type="entry name" value="CILIA-AND FLAGELLA-ASSOCIATED PROTEIN 96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31144">
        <property type="entry name" value="UPF0602 PROTEIN C4ORF47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15239">
        <property type="entry name" value="CFAP96-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5474764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="288" mass="33278" checksum="F7A9C85684818E51" modified="2021-09-29" version="1">MVFSIPSYLGVGDRYKRPIDARAHGATFLVSRPKTGTNPDALFDKELHHFWNGERCEDAETMRRRQQMESAEKNLTPNGFVCSSPTPKPSGLGSYFGCFQSTPYPHLPEHPEEHSHAIAKRELPPRGVYTSPGKKGCGYGYAHVTLSDMGSDYIATIYEQPRINERREREEWKKKMPAVPFYPAGREGFTFDESLATGASRCYIMTVPFKEKRPERVFTHFRIDQPWRPAGYVEDKPATIEYWEDPYRGYDPRKEPKEYVKKPSDAVFLPSSRNDNFWYTQSIVFKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GJK7</accession>
    <name>A0A836GJK7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ADP-ribosylation factor-like protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LSCM4_03537</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061472.1">
        <property type="nucleotide sequence ID" value="XM_067205535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GJK7"/>
    <dbReference type="SMR" id="A0A836GJK7"/>
    <dbReference type="GeneID" id="92359469"/>
    <dbReference type="KEGG" id="loi:92359469"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000281">
        <property type="entry name" value="ADP-ribosylation factor-like protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044612">
        <property type="entry name" value="ARL2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45697">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 11 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="23"/>
            <end position="30"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="125"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG5473469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="179" mass="20188" checksum="FA01B11F1E8917BE" modified="2021-09-29" version="1">MGLLTLLRKLKRSEVEPRILILGLDNAGKTSILRKLSDEDPTTTQATQGFNIKSINCEGFKLNMWDIGGQKAIRAYWPNYYDEVDCLIYVVDAADRRRLEETAIELDALLQEQKLREAPILIFSNKCDLATALSPEDVSTALNLHSLRDRTWSIQKCSAKTGEGLHEGLEWAVKSLKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GJP0</accession>
    <name>A0A836GJP0_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_02325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5468932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067204357.1"/>
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    <dbReference type="GeneID" id="92358291"/>
    <dbReference type="KEGG" id="loi:92358291"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="381"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5468932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="448" mass="48515" checksum="7B17B827995A360A" modified="2021-09-29" version="1">MSSGDKSARAPGGDTRRLGISGGSRSEIVSPECEAGVEVHVLAPLRAQRKPMMTSSARGDSPTTATVDMFVADADSLAFPSTTSAMLFVSFRARWAHAVQAFQFALTEPGMALIAAFILFAMSFFGCITAFFIAPSLTTSLATHIQRSLDNVVSEVGISTLPKSWMPDVVSTVQCGLRALLVPSLLVGAAGVWVLSDPERRRPGKWLMGYSVLVLALGFMLLYLLLRVLLSGQLGLWQSTLLDLFANVLEKLDDEAGQCIWEYAHPCSGFSSCCVTNLSALNMSEEELLKDDEVWRSVCFVTMQSGQAVRRRRSHGDSDVLEDITKAVQGQCGQIAAYIDLNEDYPLYSTACALANRSVEITPAHSMSCEDYFIGHFSSTIGFDMCLLFGMTVCSLVSGVVAFISNHQRPRMTEFLPVNMPSSSAKESAMVAKGDGLDDCRGVSRKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GJU5</accession>
    <name>A0A836GJU5_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061607.1">
        <property type="nucleotide sequence ID" value="XM_067205670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GJU5"/>
    <dbReference type="GeneID" id="92359604"/>
    <dbReference type="KEGG" id="loi:92359604"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="344"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5473604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="407" mass="41403" checksum="B06D9A5949021D0A" modified="2021-09-29" version="1">MFNPYDPRRVYLDPNSSSTSIPFSYATASSSSQVPLGPRPEGNIVYLTPGFTSQVPGTSSASSSTAELVNPQLLGTQAASQRTGEASTAATTSASVSIVNLMQPAQPLPNISYDPARMSTGTTAPFPRYLATQPTFSQSNTPLQAAQPQMLQQPIVLQANSPSPTFAPSGAAATSPGSQRLMLISGPAPARSMNPFYPYQATAAGAPAAMQSSSSHHPPATTTQLISPLQVASHASQSRSGSGNFAYVVESGSPAPLLAYSMPQQSFVPVTNPPWSPGAALSVLSSASGTPTMAPRKGNSGVEAASLRSSAQQSLATSVVVGSQNNLPGTSPASPDAAPTSMPTARAGGTTAAAGGSPDGIQPAALGVRNFFAPEPVGSCLLPNLPLDPIIPPLALPCPRWGKLPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GKT1</accession>
    <name>A0A836GKT1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pre-rRNA-processing protein TSR2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_04186</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TSR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062112.1">
        <property type="nucleotide sequence ID" value="XM_067206175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GKT1"/>
    <dbReference type="SMR" id="A0A836GKT1"/>
    <dbReference type="GeneID" id="92360109"/>
    <dbReference type="KEGG" id="loi:92360109"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019398">
        <property type="entry name" value="Pre-rRNA_process_TSR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21250">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN TSR2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="143"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="209"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5475604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="24706" checksum="83F3BDAD676563CE" modified="2021-09-29" version="1">MQANSAQMSYGAQLRASMQTLRASDAQFEQFTRGLRAVLQQWTALQLVAQHCDSRAPAVLYEDLCAWHQRDGEVYADDMEVYFEEFFDNVRFVRIEDDSMQEVGTVLHDMYSRCCLNDFSLVEHYLQTLAIYAQTNPVAMSVNGGTAEDVDDVSEDGEADDVGCEEDMGNAGEAPAPMQEPGLKASPQPPQASREQQQQPQRKKRKNASVRSKNGWNIVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GLV9</accession>
    <name>A0A836GLV9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PTHB1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_02796</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060368.1">
        <property type="nucleotide sequence ID" value="XM_067204816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GLV9"/>
    <dbReference type="SMR" id="A0A836GLV9"/>
    <dbReference type="GeneID" id="92358750"/>
    <dbReference type="KEGG" id="loi:92358750"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034464">
        <property type="term" value="C:BBSome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028074">
        <property type="entry name" value="PHTB1_GAE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028073">
        <property type="entry name" value="PHTB1_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026511">
        <property type="entry name" value="PTHB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055364">
        <property type="entry name" value="PTHB1_CtH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055363">
        <property type="entry name" value="PTHB1_hp_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055362">
        <property type="entry name" value="PTHB1_pf_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20991">
        <property type="entry name" value="PARATHYROID HORMONE-RESPONSIVE B1 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20991:SF0">
        <property type="entry name" value="PROTEIN PTHB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14727">
        <property type="entry name" value="PHTB1_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23339">
        <property type="entry name" value="PTHB1_CtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14728">
        <property type="entry name" value="PTHB1_GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23338">
        <property type="entry name" value="PTHB1_hp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23337">
        <property type="entry name" value="PTHB1_pf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PTHB1 N-terminal" evidence="2">
        <location>
            <begin position="3"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="PTHB1 N-terminal" evidence="2">
        <location>
            <begin position="168"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="PTHB1 GAE" evidence="3">
        <location>
            <begin position="537"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="PTHB1 platform" evidence="4">
        <location>
            <begin position="628"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="PTHB1 hairpin" evidence="5">
        <location>
            <begin position="736"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="domain" description="PTHB1 C-terminal helix bundle" evidence="6">
        <location>
            <begin position="841"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5470102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="918" mass="99768" checksum="0E613AF5886FABEE" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GLX5</accession>
    <name>A0A836GLX5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Short chain dehydrogenase/reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_01393</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059138.1">
        <property type="nucleotide sequence ID" value="XM_067203447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GLX5"/>
    <dbReference type="GeneID" id="92357381"/>
    <dbReference type="KEGG" id="loi:92357381"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF284">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5466248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="440" mass="48499" checksum="FF5DF3BB0A62BA72" modified="2021-09-29" version="1">MRVGYKSETGACLLGAATFAACFFIPRHLLTAVIPLWIVASRLVSRGSVNHARPVTDADPADKQAHARFVMSRDMPLAKRPVAIVTGTNSGIGYWTAVGLAVEGYEVVATCRSAVLTQQTVARIRQEAESRRRAQPQRYAHSPASVLVEGHLPLECEDFDSVRAFAEWVAKKYGQRNVHVLVNNAGCMRKELTFSRLHPKLELHTAVNFLGPLLLTELLLPVLERNGGRVVYVSSEAHRFPQSLLLPGRFGFWESTSAFSRCNGLIAGKLLNALKEVNQGAGKSSGSLQAHSTRLAFTRYGTSKLLNTYHAHEIARRYRDTKDEAHRVYACSLHPGCVVTNFSRDILSSFANVIFSRVSLLFLKTSEEGAQTTLHCAMCPREELELVSPSGEKPTRSVDAVSPYFVECKDQTTKMLLAYGWDVSEAAAIVQWGRQQVGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GMA4</accession>
    <name>A0A836GMA4_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_01609</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059348.1">
        <property type="nucleotide sequence ID" value="XM_067203657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GMA4"/>
    <dbReference type="SMR" id="A0A836GMA4"/>
    <dbReference type="GeneID" id="92357591"/>
    <dbReference type="KEGG" id="loi:92357591"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24142">
        <property type="entry name" value="ACL4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF10">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="307"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="309"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5466458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="338" mass="37924" checksum="B8FA925459C7D4DC" modified="2021-09-29" version="1">MDASALLALAQSAVDCGNVKAACEFYEVALAQSPNNDEVLEAYAEIMIHHAQDIPRAQQMLRHAIDINPNQGYVKYLNLAQLCEAKEALKCYEKAYEIARLMLHGCRKKKMKKALQETMATICCAVAELYLTDLCFEENAEQQCEQAVSRALKLNSDIVEPHQLQASLRLSQCRPDEALQSLRRAVDVTHRLGEEHQPTYESKIELGRLLMQVDPAEAFQFLLEVLQYGDNNPYVWFLLGESARMRGRYVDAARLLRRARVMLVVSDGDAASLKEVDEAISVLVQEMGGPEAVAQVKDLDHPYPLELLQAEDDQGAEEDGDDNLTEPEREPCDNEDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GNL1</accession>
    <name>A0A836GNL1_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_04658</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000023">
        <property type="protein sequence ID" value="KAG5478426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063087.1">
        <property type="nucleotide sequence ID" value="XM_067206640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GNL1"/>
    <dbReference type="GeneID" id="92360574"/>
    <dbReference type="KEGG" id="loi:92360574"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40743">
        <property type="entry name" value="NUCLEOTIDE-DIPHOSPHO-SUGAR TRANSFERASE CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40743:SF1">
        <property type="entry name" value="POSSIBLE GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5478426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="317" mass="35012" checksum="848BFA113AC2A535" modified="2021-09-29" version="1">MNIVTSYFLVRKLPGSLAIGGDVLEHQQARQREYMECLRFNQQHPGVASIHLIVEGTDAYEHLLKHVLCNPDFQNESTLTASATPTTARRSKRDAAPIVPVVRCASGMPLYADLFAYANQLLSHRLTMVCNADVYLSPGHFSLSAVEDLFRKSSTIPHVPAAPGGECQTLTNGMAEGEAVRLDYAQSRGNPLALALTRYESDSLLDAPFLYDYRGSHDAFVLVPPVPTSFLRSVAHPQNCYKAENIVLHELQRSGYLTLNPTLGDGIRLVHHHAADLRQWFPPVDESRYGRAQPSTVAQAASRILEEAHERSLPMSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GNR3</accession>
    <name>A0A836GNR3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cleavage stimulation factor 50 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_02338</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5468945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059922.1">
        <property type="nucleotide sequence ID" value="XM_067204370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GNR3"/>
    <dbReference type="SMR" id="A0A836GNR3"/>
    <dbReference type="GeneID" id="92358304"/>
    <dbReference type="KEGG" id="loi:92358304"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005848">
        <property type="term" value="C:mRNA cleavage stimulating factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001781">
        <property type="entry name" value="WD domain, G-beta repeat, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044633">
        <property type="entry name" value="CstF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44133">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44133:SF2">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="366"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="417"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="210"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="333"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5468945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="546" mass="59076" checksum="9E11B3C012EB5F2E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GNR6</accession>
    <name>A0A836GNR6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Amino acid permease/transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_05988</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Polyamine:cation symporter (PHS) (TC 2.A.3.12) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000011">
        <property type="protein sequence ID" value="KAG5485352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065089.1">
        <property type="nucleotide sequence ID" value="XM_067207915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GNR6"/>
    <dbReference type="SMR" id="A0A836GNR6"/>
    <dbReference type="GeneID" id="92361849"/>
    <dbReference type="KEGG" id="loi:92361849"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015203">
        <property type="term" value="F:polyamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044566">
        <property type="entry name" value="RMV1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45826:SF2">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45826">
        <property type="entry name" value="POLYAMINE TRANSPORTER PUT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="220"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="504"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5485352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="573" mass="62326" checksum="11AF2E007B469CD5" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GPY6</accession>
    <name>A0A836GPY6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phosphatidylethanolamine N-methyltransferase</fullName>
            <shortName evidence="14">PEAMT</shortName>
            <shortName evidence="14">PEMT</shortName>
            <ecNumber evidence="14">2.1.1.17</ecNumber>
            <ecNumber evidence="14">2.1.1.71</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Phospholipid methyltransferase</fullName>
            <shortName evidence="14">PLMT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LSCM4_03336</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">LSCM4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the three sequential steps of the methylation pathway for the biosynthesis of phosphatidylcholine, a critical and essential component for membrane structure. Uses S-adenosylmethionine (S-adenosyl-L-methionine, SAM or AdoMet) as the methyl group donor for the methylation of phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE) to phosphatidylmonomethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine, PMME), PMME to phosphatidyldimethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine, PDME), and PDME to phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), producing S-adenosyl-L-homocysteine in each step.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phosphocholine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32739"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64572"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32735"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64572"/>
            <dbReference type="ChEBI" id="CHEBI:64573"/>
            <dbReference type="EC" id="2.1.1.71"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11164"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64573"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="2.1.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 14">Phospholipid metabolism; phosphatidylcholine biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Endoplasmic reticulum membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Mitochondrion membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.17" evidence="14"/>
    <dbReference type="EC" id="2.1.1.71" evidence="14"/>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067205347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GPY6"/>
    <dbReference type="GeneID" id="92359281"/>
    <dbReference type="KEGG" id="loi:92359281"/>
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        <property type="component" value="Chromosome 31"/>
    </dbReference>
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        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000773">
        <property type="term" value="F:phosphatidyl-N-methylethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:phosphatidylethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="PLMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024960">
        <property type="entry name" value="PEMT/MFAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15458">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15458:SF5">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005444">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51599">
        <property type="entry name" value="SAM_PEMT_PEM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11 14 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12 14" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="13 14" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="topological domain" description="Lumenal" evidence="14">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="14">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="14">
        <location>
            <begin position="132"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="14">
        <location>
            <begin position="197"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="115"/>
            <end position="117"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="198"/>
            <end position="199"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG5471782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="225" mass="23985" checksum="D1F8C8CF36E87108" modified="2021-09-29" version="1">MAHASTTRAASRIHYGSLGMAAVAIAGLPTVWNIVARNEYRRHTIEKRVGGKKAGAYLLAAAIFVASGLRDYTFHHAMAQTPSSVFPILCTRAFGAENAGVVGNVMRGAGAALLVAGTTLVVSSFLRLGITGTYLGDYFGILMDERVTAFPFSHFDNPMYLGATLNFLAASIARNSAIGVLLTGWVAVVYHVSTKCFENPFTAMIYSKREEGRAAAGVFAKAKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GQ12</accession>
    <name>A0A836GQ12_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DoxX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_00939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059655.1">
        <property type="nucleotide sequence ID" value="XM_067203005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GQ12"/>
    <dbReference type="GeneID" id="92356939"/>
    <dbReference type="KEGG" id="loi:92356939"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5467853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="156" mass="16922" checksum="52ADFF7A9B5F9884" modified="2021-09-29" version="1">MLRNLIRYTGLVLVLLVFIFSGIDKLAAPSVSAALLAKSNFPRMLATMGIQLSPTECIHVVRAVGVTCVSFSLFILLGVGRSFFSFLMAIGMVIATVALYVDFDYPLATSEENTKHILENMSIAGALLFVSGSGHRSRRYSQARVASDSDRAKKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GR43</accession>
    <name>A0A836GR43_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 4">Histone deacetylase</fullName>
            <ecNumber evidence="1 4">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_05784</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="1 4"/>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063487.1">
        <property type="nucleotide sequence ID" value="XM_067207714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GR43"/>
    <dbReference type="SMR" id="A0A836GR43"/>
    <dbReference type="GeneID" id="92361648"/>
    <dbReference type="KEGG" id="loi:92361648"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09991">
        <property type="entry name" value="HDAC_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000017">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF10">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037913">
        <property type="entry name" value="His_deacetylse_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="9">
        <location>
            <begin position="43"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="402"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="404"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR037913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5479776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="438" mass="48229" checksum="A306DB7CF5746C65" modified="2021-09-29" version="1">MHALHKEDDQAPLLHAESRGRVALIDTSGYASDMNISAFVPQHAMKPYRVLAAMEIIRSLKIDAHCRTVVPPLVKVEELMTYHTDTYLANLGLHSCRSWLWNTDTSKVFFSGDCPPVEGLMEHSIATASGTLMGAVLLNSGQVDVAVHWGGGMHHAKCGECSGFCYVNDIVLGILELLKCHDRVLYIDIDMHHGDGVDEAFCKSDRVFTLSLHKFGESFFPGTGHPRDVGYGSGRYYSMNLAVWDGITDFYYLGLFKHALHSIVRRYSPDVIVLQCGADSLAGDRLGLLNLSSFGHGQCVQAVRDLGIPMLALGGGGYTVRNVAKLWAYETSILTGHPLPPNTVLSVTEMPLSGWLFQDSPLLIVAQDRSNHVLPGLHCQRAYQMITEQIDRHVPHIQLHPRLPKAATTAAAAPGGKTREEDGRQPSQMLRENETKIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GTZ9</accession>
    <name>A0A836GTZ9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_03382</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">LSCM4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060942.1">
        <property type="nucleotide sequence ID" value="XM_067205390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GTZ9"/>
    <dbReference type="GeneID" id="92359324"/>
    <dbReference type="KEGG" id="loi:92359324"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032595353" description="GOLD domain-containing protein" evidence="10">
        <location>
            <begin position="37"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="11">
        <location>
            <begin position="49"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5471825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="263" mass="28955" checksum="3C18F1229B710E05" modified="2021-09-29" version="1">MLPCRRAAAGGVLAPVGNVVLALLLLLLHRNSVTVAAATYGSKIEAGETECYTEIVEAGGTLGFTFRVTDGGAFDVNAVMKVRFTPPVDKTTELSRFHYNAHFAGLRDRQREVVLNTWHRATDGSYTYTASSVLKTRHGLPEEVSVCFNNSFSTFSPKWVRFSIMKRDVLDVDPDAVNKVENAMEEELHRYGTILFGLAQDANALQLVGESDRVKLNSLAKIMAAGLALNIMVLLTMAAYQYLSLSRFLARQGRRGKFTISTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GU04</accession>
    <name>A0A836GU04_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-splicing factor Syf1/CRNKL1-like C-terminal HAT-repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_00462</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the crooked-neck family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058642.1">
        <property type="nucleotide sequence ID" value="XM_067202541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GU04"/>
    <dbReference type="SMR" id="A0A836GU04"/>
    <dbReference type="GeneID" id="92356475"/>
    <dbReference type="KEGG" id="loi:92356475"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001266">
        <property type="entry name" value="Hypothetical_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055430">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF3">
        <property type="entry name" value="CROOKED NECK-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23231">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1/CRNKL1-like C-terminal HAT-repeats" evidence="8">
        <location>
            <begin position="61"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="365"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5465011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="823" mass="93203" checksum="72910CF572689BD6" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GWR0</accession>
    <name>A0A836GWR0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphatidylserine decarboxylase</fullName>
            <ecNumber evidence="3">4.1.1.65</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_01662</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <cofactor evidence="1">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Phospholipid metabolism; phosphatidylethanolamine biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="3"/>
    <dbReference type="EMBL" id="JAFHLR010000035">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A836GWR0"/>
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    <dbReference type="KEGG" id="loi:92357644"/>
    <dbReference type="UniPathway" id="UPA00558"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033177">
        <property type="entry name" value="PSD-B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00163">
        <property type="entry name" value="PS_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF6">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="8" id="KW-0456">Lyase</keyword>
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    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00001928"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5466511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="352" mass="39107" checksum="E188FD0321622EF8" modified="2021-09-29" version="1">MAPLRLTSPSRFYKGHCDVRLSNPTRRWLYHHLLLGGIGAFGCYLTLRYQRAAREASKHPEDGNCLCSSDMVDFLRYMPFNLFSNVAGRLAENESVPAWVHNCFVQALVYWYALDMSESEQRAGFDTFQQFYVRDWTQTARPVDAAASVVAPCDGQVLAVHTDVKSTSLVQVKGLSYGMRSLLQDTPPPLNAETHRRVAVVIHMRNKDFHHVIAPLSFACEKSVYVPGSLLPTTAAGYHWIPSVLTINERLVLQGSSCGKAGLPVYMALVGSTLTGRITLYMDKRVRTNYLDPPAYAVHLPYASKPSLARGERLATFNWGSSVVLVMDVPKSCTALKRAGDVVKAGEALFQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GX38</accession>
    <name>A0A836GX38_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061493.1">
        <property type="nucleotide sequence ID" value="XM_067205556.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="92359490"/>
    <dbReference type="KEGG" id="loi:92359490"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="578"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="838"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="578"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="598"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="854"/>
            <end position="864"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5473490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1047" mass="107432" checksum="445372E50B5EAE58" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GXI4</accession>
    <name>A0A836GXI4_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_06525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000019">
        <property type="protein sequence ID" value="KAG5480954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063955.1">
        <property type="nucleotide sequence ID" value="XM_067208443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GXI4"/>
    <dbReference type="GeneID" id="92362377"/>
    <dbReference type="KEGG" id="loi:92362377"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5480954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="117" mass="14015" checksum="8D1795BA3C21271E" modified="2021-09-29" version="1">MPQDTYFRRAINWMYGDDAYLQNFPTKDLGDKHINELLGRHPYHPYDPDMKADNPCYELNTLFYECMEADHVEGYELYQKHVACYFPYKVDLMKCIAKEKRRHRMEVEALEGKGPQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GXR4</accession>
    <name>A0A836GXR4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_03245</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">LSCM4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060810.1">
        <property type="nucleotide sequence ID" value="XM_067205258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GXR4"/>
    <dbReference type="GeneID" id="92359192"/>
    <dbReference type="KEGG" id="loi:92359192"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000328">
        <property type="entry name" value="Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039927">
        <property type="entry name" value="Ribosomal_mL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21396">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21396:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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                <person name="Bates M.D."/>
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<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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    <dbReference type="AlphaFoldDB" id="A0A836H0C7"/>
    <dbReference type="GeneID" id="92357156"/>
    <dbReference type="KEGG" id="loi:92357156"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5468070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="81" mass="8569" checksum="3C2299C1322CEFE2" modified="2021-09-29" version="1">MCGEHDAGVIVRIIGSEVAVPAFVYLYGQKDLCYKALSAVGRVVRTSCNPAASQGYVENAGGAVLLELIMNRCKGCIFVCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H0X7</accession>
    <name>A0A836H0X7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_04127</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062053.1">
        <property type="nucleotide sequence ID" value="XM_067206116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H0X7"/>
    <dbReference type="SMR" id="A0A836H0X7"/>
    <dbReference type="GeneID" id="92360050"/>
    <dbReference type="KEGG" id="loi:92360050"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010389">
        <property type="term" value="P:regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07829">
        <property type="entry name" value="STKc_CDK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000821">
        <property type="entry name" value="Cdc2-related kinase 6, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000611">
        <property type="entry name" value="CMGC family protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF417">
        <property type="entry name" value="CONTROL PROTEIN 2 HOMOLOG 6, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="24"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5475545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="328" mass="37584" checksum="9A5F1346437A2CF4" modified="2021-09-29" version="1">MSTAVNNLNGKLDQLDITALSAAYEPEEVLGEGTYGIVFRACNKATGAKYAIKKLRLDGFSEGVPATTIREATLLHDLNDNPNVVKLLDVVCSEHRVYLIFELLDEDLRTFIKRYRPVSGQKPTNGTAVPLHMVRDFTRQMLYALWTCHNNRILHRDLKPGNILVANYRDKMTGETKFYVKLADFGLARMFEMSVQTYTHEVMTLWYRSPEIILGDRHYTPAADIWSVGCIVAEMILGYSLFRGENWRDQLDKVFYVVGTPTEKTWPGVTKLPGYDRNFKVYHVAPLPTRLRDYDEKAVEFIAYLLVTNPKLRPTIPDILEHPFMKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H1G1</accession>
    <name>A0A836H1G1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cysteine desulfurase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_02487</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060068.1">
        <property type="nucleotide sequence ID" value="XM_067204516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H1G1"/>
    <dbReference type="SMR" id="A0A836H1G1"/>
    <dbReference type="GeneID" id="92358450"/>
    <dbReference type="KEGG" id="loi:92358450"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004810">
        <property type="term" value="F:CCA tRNA nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1510">
        <property type="entry name" value="THUMP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020536">
        <property type="entry name" value="ThiI_AANH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="CYSTEINE DESULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601">
        <property type="entry name" value="CYSTEINE DESULFURYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02568">
        <property type="entry name" value="ThiI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143437">
        <property type="entry name" value="THUMP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thil AANH" evidence="7">
        <location>
            <begin position="224"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class V" evidence="6">
        <location>
            <begin position="470"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class V" evidence="6">
        <location>
            <begin position="588"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="447"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5469091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="795" mass="88109" checksum="12888EE47D6DBB6C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H1R2</accession>
    <name>A0A836H1R2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_03683</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061616.1">
        <property type="nucleotide sequence ID" value="XM_067205679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H1R2"/>
    <dbReference type="SMR" id="A0A836H1R2"/>
    <dbReference type="GeneID" id="92359613"/>
    <dbReference type="KEGG" id="loi:92359613"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00106">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000116">
        <property type="entry name" value="Putative kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF36">
        <property type="entry name" value="KINESIN HEAVY CHAIN ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3 4" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="6">
        <location>
            <begin position="10"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="377"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="89"/>
            <end position="96"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5473613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="590" mass="65021" checksum="5B55D37F6A37C44E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H2P8</accession>
    <name>A0A836H2P8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_04614</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="JAFHLR010000023">
        <property type="protein sequence ID" value="KAG5478382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063043.1">
        <property type="nucleotide sequence ID" value="XM_067206596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H2P8"/>
    <dbReference type="SMR" id="A0A836H2P8"/>
    <dbReference type="GeneID" id="92360530"/>
    <dbReference type="KEGG" id="loi:92360530"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097014">
        <property type="term" value="C:ciliary plasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000002">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="27"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="227"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="227"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5478382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="283" mass="30764" checksum="3033ABA95241D82F" modified="2021-09-29" version="1">MSRMSVPPKVGKRLGINVEKNTNPKVFFEISVDNKSAGRIVMELYADTVPKTAENFRALCTGEKGKGRSGKPLHYKNSVFHRVIPNFMIQGGDFTRGNGTGGESIYGMTFRDESFSGKAGRHTGLGCLSMANAGPNTNGSQFFICTAATPWLDGKHVVFGRVVDGLDVVKKVERLGSSSGKTRSRIVVSDCGELAAENTKEQQQLQQQQLAKAVVDRRPVEGKMVVAEKKAPSAKEEALPQASATSAARKRVREVNEDEARLARLREKKAKLAALRARAEGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H3D9</accession>
    <name>A0A836H3D9_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_02641</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060220.1">
        <property type="nucleotide sequence ID" value="XM_067204668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H3D9"/>
    <dbReference type="SMR" id="A0A836H3D9"/>
    <dbReference type="GeneID" id="92358602"/>
    <dbReference type="KEGG" id="loi:92358602"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5469243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1011" mass="107957" checksum="41FD5B6B61462626" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H3L7</accession>
    <name>A0A836H3L7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HD/PDEase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_02940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060512.1">
        <property type="nucleotide sequence ID" value="XM_067204960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H3L7"/>
    <dbReference type="SMR" id="A0A836H3L7"/>
    <dbReference type="GeneID" id="92358894"/>
    <dbReference type="KEGG" id="loi:92358894"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008832">
        <property type="term" value="F:dGTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006203">
        <property type="term" value="P:dGTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3210.10:FF:000039">
        <property type="entry name" value="Protein CBG02420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050135">
        <property type="entry name" value="dGTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373">
        <property type="entry name" value="DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373:SF4">
        <property type="entry name" value="DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD/PDEase" evidence="2">
        <location>
            <begin position="71"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="552"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="552"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5470246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="672" mass="74969" checksum="F17DFAA8FFCC6967" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H5N4</accession>
    <name>A0A836H5N4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA mismatch repair protein S5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_05433</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5478035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062942.1">
        <property type="nucleotide sequence ID" value="XM_067207374.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836H5N4"/>
    <dbReference type="GeneID" id="92361308"/>
    <dbReference type="KEGG" id="loi:92361308"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16926">
        <property type="entry name" value="HATPase_MutL-MLH-PMS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000079">
        <property type="entry name" value="DNA mismatch repair protein MLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032189">
        <property type="entry name" value="Mlh1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF12">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16413">
        <property type="entry name" value="Mlh1_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="7">
        <location>
            <begin position="330"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="286"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="593"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="678"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="834"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="298"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="593"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="654"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5478035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1309" mass="136486" checksum="33C7B41817D4AB38" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H6M4</accession>
    <name>A0A836H6M4_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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            <begin position="304"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name type="scientific">Leishmania orientalis</name>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG5478575.1"/>
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    <dbReference type="KEGG" id="loi:92360723"/>
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    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="31"/>
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            <begin position="32"/>
            <end position="163"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5478575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="163" mass="18262" checksum="BF55DE76118210D1" modified="2021-09-29" version="1">MSMRRRTLPVGVIPAMLLLCFLSGAVLNTAAYHEGPRMSPLLQCSEDFSLVCNSSTSTRGLWGCMMRNIDRISNELCKDYVIGFRACTSDAEKRSSCVFPAADYATSVRRCLRTIPEEKITEACRSSRFYYPIAEVRAAKRGYWDNAQAKEVVEGERTGVRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H748</accession>
    <name>A0A836H748_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Syntaxin binding protein 1</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">LSCM4_05233</name>
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        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062486.1">
        <property type="nucleotide sequence ID" value="XM_067207183.1"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A836H748"/>
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    <dbReference type="KEGG" id="loi:92361117"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
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        <property type="entry name" value="Sec-1-like_dom1"/>
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        <property type="entry name" value="Sec1-like"/>
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        <property type="entry name" value="Sec1-like_dom2"/>
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        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="538"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="564"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="581"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5476253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="734" mass="79310" checksum="45416F25C210C156" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H8Z4</accession>
    <name>A0A836H8Z4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_04370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062564.1">
        <property type="nucleotide sequence ID" value="XM_067206355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H8Z4"/>
    <dbReference type="GeneID" id="92360289"/>
    <dbReference type="KEGG" id="loi:92360289"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="100"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="259"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="538"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="568"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5477153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="594" mass="63189" checksum="60E9B96CD6FF58A6" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HA86</accession>
    <name>A0A836HA86_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1935 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_06202</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <end position="250"/>
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        <location>
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            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5480435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="278" mass="29778" checksum="FEA310B2197D4B14" modified="2021-09-29" version="1">MGAAPADDATHFFVSAPDSAHAAPEATSVSANRLPASAAASAAAIPSAPAPNEANMGRKTYGLATSDSDSVFGAVRANNAAAETGTSAVATAPAEEVSDSSTERAEEPVEEQATDPSQHRQLNAVSLHQESQIHRMVDKNSPYVGPGPAAEFPIDHIYRCFDQQNGLLFRLVNNKRHMWAFYNDTTDYMMRVTVTFGPESSISALGKTRQTVLDKETGECRLVLDLAPGETQKFMRGEYNGFITCYDASPIDCSTDPDAEAKLPQKQRQGLVKSLPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000016">
        <property type="protein sequence ID" value="KAG5482432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067207624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HA89"/>
    <dbReference type="GeneID" id="92361558"/>
    <dbReference type="KEGG" id="loi:92361558"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5482432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="113" mass="13130" checksum="9BC68B392676640B" modified="2021-09-29" version="1">MLQKTKEAPSEEELNLRVRQGLQKRKRCALCTQTFYVNELPGAITHKSILELRQKWGIEVRRGDRMPPPSQLYKREEICIFCMQFFDTTGSMQTQQKLLASTRDGISPSLTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HCY6</accession>
    <name>A0A836HCY6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cell division control protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_06921</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CEF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000017">
        <property type="protein sequence ID" value="KAG5481845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067208831.1"/>
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    <dbReference type="GeneID" id="92362765"/>
    <dbReference type="KEGG" id="loi:92362765"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cell division control protein, putative"/>
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    </dbReference>
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        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="CDC5L/Cef1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
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        <property type="entry name" value="CELL DIVISION CYCLE 5-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CELL DIVISION CYCLE 5-LIKE PROTEIN"/>
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        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="2"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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        <location>
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            <end position="58"/>
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    </feature>
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    </feature>
    <feature type="domain" description="HTH myb-type" evidence="11">
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        </location>
    </feature>
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        <location>
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            <end position="96"/>
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            <end position="174"/>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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    </feature>
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    </feature>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
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        <source>
            <dbReference type="EMBL" id="KAG5481845.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="807" mass="89460" checksum="AC077C69AEE6BCB7" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HEY5</accession>
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        <submittedName>
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        </submittedName>
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            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062123.1">
        <property type="nucleotide sequence ID" value="XM_067206186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HEY5"/>
    <dbReference type="GeneID" id="92360120"/>
    <dbReference type="KEGG" id="loi:92360120"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5475615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="513" mass="59524" checksum="E362EC46592B26E1" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HJ90</accession>
    <name>A0A836HJ90_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S ribosomal protein L21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_01092</name>
        <name evidence="5" type="ORF">LSCM4_05581</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">LSCM4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5468005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFHLR010000016">
        <property type="protein sequence ID" value="KAG5482328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059807.1">
        <property type="nucleotide sequence ID" value="XM_067203157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HJ90"/>
    <dbReference type="SMR" id="A0A836HJ90"/>
    <dbReference type="GeneID" id="92357091"/>
    <dbReference type="KEGG" id="loi:92357091"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.70:FF:000001">
        <property type="entry name" value="60S ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.70">
        <property type="entry name" value="Ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001147">
        <property type="entry name" value="Ribosomal_eL21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018259">
        <property type="entry name" value="Ribosomal_eL21_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036948">
        <property type="entry name" value="Ribosomal_eL21_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20981">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01157">
        <property type="entry name" value="Ribosomal_L21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01171">
        <property type="entry name" value="RIBOSOMAL_L21E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5468005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5482328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="159" mass="18016" checksum="E18ECF4B8CB86DA2" modified="2021-09-29" version="1">MVHSYGYKSGTRHLFAKKFRKHGVPSVSTILTNVKVGDYVDVVADSAVREGMPHKYYHGRTGIVWNVTPRGVGVIVNKPVRTRTLRKRICVRFEHVRKSRCQEAFKAKEHQFQAYLAAKKAGKALPPLKKSSRQGGIVRPKNVEVLARRVADYEAMVPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HJR3</accession>
    <name>A0A836HJR3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_01805</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">LSCM4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000022">
        <property type="protein sequence ID" value="KAG5479216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063309.1">
        <property type="nucleotide sequence ID" value="XM_067203850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HJR3"/>
    <dbReference type="SMR" id="A0A836HJR3"/>
    <dbReference type="GeneID" id="92357784"/>
    <dbReference type="KEGG" id="loi:92357784"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000009">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000037">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000347">
        <property type="entry name" value="Proteasome regulatory ATPase subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="10">
        <location>
            <begin position="224"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5479216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="444" mass="49529" checksum="0A8D149D20AF1633" modified="2021-09-29" version="1">MPSAKEVAEARAYAQAQEEAADKRKLQNITEAELNELDTLTNDQLRTRARNLHQETQTLRSFENRSKQELITLKRDVEMGKKRVKENNRLPYLVASIAEVLDLSDDEDEAEELAVGRKKPERKQKSAVIKTTNRYTVFLPVAGLVDAERLSPEDLVGVNKDTFLVLDTLPPDYDSRVKAMEIDEKPKEKYTDVGGLDKQINELIEAVVMPITHKEQFEKIGIQPPKGVLLYGSPGTGKTMLARACAAATDACILRLAGPQLVQMFIGDGARIVRDAFALAKKKAPSIIFIDELDAVGSKRSDEGKHGSREVQRTMLELLSQLDGFGSSDDVKVIAATNRIDVLDPALLRSGRLDRKVEFPMPDEEARASILEIHSRRMNLNKDVNFKELARCTDDMNGAQLKAVCVEAGMLALRHDRTYVAHEDFVEGVAAVQARKKTNLNYYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HKA8</accession>
    <name>A0A836HKA8_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LSCM4_04637</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000023">
        <property type="protein sequence ID" value="KAG5478405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063066.1">
        <property type="nucleotide sequence ID" value="XM_067206619.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836HKA8"/>
    <dbReference type="GeneID" id="92360553"/>
    <dbReference type="KEGG" id="loi:92360553"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000082">
        <property type="entry name" value="ABC transporter, multidrug resistance associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000630">
        <property type="entry name" value="ATP-binding cassette (ABC) transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002055">
        <property type="entry name" value="ATP-binding cassette protein subfamily C, member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000010">
        <property type="entry name" value="Multidrug resistance-associated ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF273">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="487"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="530"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="970"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1008"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1091"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1193"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="271"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="666"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="975"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1319"/>
            <end position="1554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="897"/>
            <end position="929"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG5478405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1574" mass="174046" checksum="0E771A0071C51C75" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HKL1</accession>
    <name>A0A836HKL1_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_04773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000023">
        <property type="protein sequence ID" value="KAG5478540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063201.1">
        <property type="nucleotide sequence ID" value="XM_067206754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HKL1"/>
    <dbReference type="GeneID" id="92360688"/>
    <dbReference type="KEGG" id="loi:92360688"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5478540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="349" mass="35484" checksum="CFB392D5999A16B9" modified="2021-09-29" version="1">MRPLRVKKRESTGVPAGDETPIGSTPSVSPVEGDGPAACLVPSPPPVKGWCPSLHPGHDSSPSPAAASPAPMTAFAAVEPGAGVVKFSSELDNAAVEAYLEYLTRPHTSWGSASRFAAHRREVIEEHRHSVYARSLALLRRSSFASTARSEGGGQDALEASTTSSVASAPAGFPRTAPNGSKTSTGTLRKGRLGDGGVPPLPSDTAASFSIVTHSSSGVSSTHSAIGASRTFTNIGRRGPSNKGRLSRGPTLAGSQRLCRTSSSTPTPAALGGGGLTVGGTQLLGGRANLFVVHNGHDSAVTSRTASRGGAEFPHPVVPQVGSRSAADCKRTSGVRAGALCPQSKHPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HKT6</accession>
    <name>A0A836HKT6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Hypoxanthine phosphoribosyltransferase</fullName>
            <ecNumber evidence="5 14">2.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">LSCM4_05809</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:17973"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="2.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 14">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.8" evidence="5 14"/>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063512.1">
        <property type="nucleotide sequence ID" value="XM_067207739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HKT6"/>
    <dbReference type="SMR" id="A0A836HKT6"/>
    <dbReference type="GeneID" id="92361673"/>
    <dbReference type="KEGG" id="loi:92361673"/>
    <dbReference type="UniPathway" id="UPA00591">
        <property type="reaction ID" value="UER00648"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004422">
        <property type="term" value="F:hypoxanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032263">
        <property type="term" value="P:GMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006178">
        <property type="term" value="P:guanine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046100">
        <property type="term" value="P:hypoxanthine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000006">
        <property type="entry name" value="Hypoxanthine phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050408">
        <property type="entry name" value="HGPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005904">
        <property type="entry name" value="Hxn_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01203">
        <property type="entry name" value="HGPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43340:SF1">
        <property type="entry name" value="HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43340">
        <property type="entry name" value="HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 14" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="16">
        <location>
            <begin position="40"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU364099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAG5479801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="211" mass="23524" checksum="C3CBFFBA09555479" modified="2021-09-29" version="1">MSGLTNPPSSPAGATPPRHYPMSARTLVTQDQVWAATAQCAKKIARDYKKFNLTTENPLYLLCVLKGSFIFTADLARFLADEGVPVKVEFICASSYGTGVETSGQVRMLLDVRDPVENRHIMIVEDIVDSAITLQYLMRFMLAKKPASLKTVVLLDKPSGRKVDVLVDYPVITIPHAFVIGYGMDFAEAYRELRDICVLKKEYYEKPASKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HN29</accession>
    <name>A0A836HN29_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_07965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000013">
        <property type="protein sequence ID" value="KAG5484398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067209841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HN29"/>
    <dbReference type="GeneID" id="92363775"/>
    <dbReference type="KEGG" id="loi:92363775"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="373"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5484398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="471" mass="50172" checksum="7925297E7328C42C" modified="2021-09-29" version="1">MTDMGAAVAAGSVSDGGGQAQQAASLFLRDVKHLLRWHAVAVGVALAATPVVYQVARVMAQRYRAELVNLAKDAVQREELFNGAEADSVLIDPAEEGSISISYNSDSKDAREAEGGAGDNAPAFWAGSSRSASHQPASIFTHRFGRCHSWVVSSFAHRVLAAQRAPNVQFARTCSWGVVCQYGVVVLRAATTSCLVSVSSLTVFYAGCRALDYVVPFGAPPAAAATKDAAPTSLLNAVATEPLFITAAPPSPAVNSTYGLYSFGVSAAGVWSRLFPRFGAMQTLWQRLTGCKQPLHAEWRDGLTAPLSSSPHALADSVWASLSPRGYFIVSLLPRLPSRIAAGLWWLARRSSTVLMRQWYAVSSSASPTTKVAAPGAGASANPGTPAPSQRRRRRHSTKLIHWRVSKTAMMLAGDVVFAGIVFLATSCASSTSRGGSSPRWQLVHNDANTRYDFYCWAEAICSTLSMLGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HSN6</accession>
    <name>A0A836HSN6_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_06982</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000017">
        <property type="protein sequence ID" value="KAG5481903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064263.1">
        <property type="nucleotide sequence ID" value="XM_067208889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HSN6"/>
    <dbReference type="GeneID" id="92362823"/>
    <dbReference type="KEGG" id="loi:92362823"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5481903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="241" mass="27362" checksum="DE32AD48450327DE" modified="2021-09-29" version="1">MLGLGGVWRWLRGEPTIPGVVYSDQMQNIKEDLERQQNIQWAGNLRNVRLDSAPDLIVRTSSSSAAPPGPEEQPYTFWERVGLVPVHPARVRARQYYHPITDFALYDYDELSPEEKELTAKWMARVMEFNGATPAGILCAAGCLVLPLHTIYRMPLLIAAGITGVAVEVTRAYMAASQQRQDLDDFLLAKEIWYIKNIETYQLGIPRIPRGREREYQQYVDGAGLMQAQGLPEELARDLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HU97</accession>
    <name>A0A836HU97_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_07236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000015">
        <property type="protein sequence ID" value="KAG5483025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064521.1">
        <property type="nucleotide sequence ID" value="XM_067209138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HU97"/>
    <dbReference type="GeneID" id="92363072"/>
    <dbReference type="KEGG" id="loi:92363072"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5483025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="584" mass="60395" checksum="9A59B7DB8D5B5583" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836I2F2</accession>
    <name>A0A836I2F2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AP-2 complex subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_06258</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <location evidence="5">Coated pit</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000007">
        <property type="protein sequence ID" value="KAG5486793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065587.1">
        <property type="nucleotide sequence ID" value="XM_067208182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836I2F2"/>
    <dbReference type="SMR" id="A0A836I2F2"/>
    <dbReference type="GeneID" id="92362116"/>
    <dbReference type="KEGG" id="loi:92362116"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030122">
        <property type="term" value="C:AP-2 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017104">
        <property type="entry name" value="AP2_complex_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037091">
        <property type="entry name" value="AP2_complex_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0168">Coated pit</keyword>
    <keyword evidence="5" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="8">
        <location>
            <begin position="23"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="651"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="674"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="4"/>
            <end position="5"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="51"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR037091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037091-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5486793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="960" mass="107305" checksum="842B33C6C3F311A8" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836I407</accession>
    <name>A0A836I407_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LSCM4_08018</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">LSCM4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="JAFHLR010000005">
        <property type="protein sequence ID" value="KAG5487573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065861.1">
        <property type="nucleotide sequence ID" value="XM_067209894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836I407"/>
    <dbReference type="SMR" id="A0A836I407"/>
    <dbReference type="GeneID" id="92363828"/>
    <dbReference type="KEGG" id="loi:92363828"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00268">
        <property type="entry name" value="DEADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000911">
        <property type="entry name" value="Nucleolar RNA helicase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002414">
        <property type="entry name" value="Nucleolar RNA helicase II, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059027">
        <property type="entry name" value="DD_DDX21-DDX50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044742">
        <property type="entry name" value="DEAD/DEAH_RhlB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012562">
        <property type="entry name" value="GUCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26142">
        <property type="entry name" value="DD_DDX21-DDX50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08152">
        <property type="entry name" value="GUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="15">
        <location>
            <begin position="86"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="117"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="332"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="645"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="86"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="645"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
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                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032311192" evidence="2">
        <location>
            <begin position="27"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5466266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="249" mass="26849" checksum="D86AEBE162555141" modified="2021-09-29" version="1">MRRAALTTPMGMAWLTVVSCSTAAYATRASRLCSSANAAHPNALIVARRGTPQALSPERHRHVGTGGSSPALFRPTRVTRIPPQLARLMIAVSAALLQVFVAAYQRESRKLSQEERARDAVGGAQGSTTMWSARAMSAMEAMQVLGLDRGFPELYTSVQQAEGNAMQTSTSLPLPHGKAREAAQQNFERMFALAVKEENMFLAGKLSAAYRICVDPAWDQATPGENEKTVDANPRSATEPDASEQGRSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KD04</accession>
    <name>A0A836KD04_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="16">1.3.8.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">2-methyl branched chain acyl-CoA dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">2-methylbutyryl-coenzyme A dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="31" type="ORF">LSCM4_01456</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="32" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="32" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>(2R)-2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = ethylacryloyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:65296"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:156439"/>
            <dbReference type="ChEBI" id="CHEBI:156440"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:65297"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>(2S)-2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:48256"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57337"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:88166"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:48257"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43780"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57336"/>
            <dbReference type="ChEBI" id="CHEBI:57337"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.3.8.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:43781"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>2-methylpropanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = 2-methylpropenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:44180"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57338"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:62500"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:44181"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>butanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:24004"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:24005"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>hexanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43464"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:62077"/>
            <dbReference type="ChEBI" id="CHEBI:62620"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:43465"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>valproyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-propylpent-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:65344"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:156457"/>
            <dbReference type="ChEBI" id="CHEBI:156458"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:65345"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 27">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="15">Amino-acid degradation; L-isoleucine degradation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; mitochondrial fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 27">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="31">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.5" evidence="16"/>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059200.1">
        <property type="nucleotide sequence ID" value="XM_067203509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KD04"/>
    <dbReference type="SMR" id="A0A836KD04"/>
    <dbReference type="GeneID" id="92357443"/>
    <dbReference type="KEGG" id="loi:92357443"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003853">
        <property type="term" value="F:short-chain 2-methyl fatty acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046395">
        <property type="term" value="P:carboxylic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000012">
        <property type="entry name" value="Acyl-CoA dehydrogenase short/branched chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000002">
        <property type="entry name" value="Acyl-CoA dehydrogenase short/branched chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000001">
        <property type="entry name" value="Acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF1">
        <property type="entry name" value="SHORT_BRANCHED CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016578">
        <property type="entry name" value="HsaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8 27" id="KW-0274">FAD</keyword>
    <keyword evidence="9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7 27" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12 27" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="30">
        <location>
            <begin position="36"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="29">
        <location>
            <begin position="151"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="28">
        <location>
            <begin position="259"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00037895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00039036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00039850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00042821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00049192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00049552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00051903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="EMBL" id="KAG5466310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="422" mass="46119" checksum="CD4289DEC37BFF23" modified="2021-09-29" version="1">MFRLVCKALMRPTAVALSRTSAVIVETPPNPVTYLTDDEKMLVETVRAFSLAHVVPRSRKMDEEGKMDPAVLKEAFAAGLMGIETPAELEGGGMSFFSSILAIEELARHDPAVSVTVDVQNTLVNNIFFNFANEAQRRKYLPKLAKDTVGCFCLTEASSGSDAFSLSTRAEKKGSKWVINGTKLYITNGGWAGIYLVMATVDPSKGYKGITCFVVDSSETPGVSVVRTENKLGIRASSTAELRFEDVEVPEENVIGEVGKGYKVAISILNEGRIGIGAQMLGIAQGSLDLVMPYLFQRKQFGKLIGDFQGMQMQYAECATELHAARLMVYNASRKKQNKETFIQDAAMAKYFASVVAEKTASRAVEWAGGVGFMKDFGLERFYRDAKIGAIYEGTSIIQLQTIAKMIKAKYDESSSPLGMQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KDT9</accession>
    <name>A0A836KDT9_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_01944</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061020.1">
        <property type="nucleotide sequence ID" value="XM_067203983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KDT9"/>
    <dbReference type="GeneID" id="92357917"/>
    <dbReference type="KEGG" id="loi:92357917"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5472624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="596" mass="66521" checksum="69918ACEEC09A6A2" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KDU1</accession>
    <name>A0A836KDU1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CMP/dCMP-type deaminase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_02890</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family. ADAT3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060462.1">
        <property type="nucleotide sequence ID" value="XM_067204910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KDU1"/>
    <dbReference type="GeneID" id="92358844"/>
    <dbReference type="KEGG" id="loi:92358844"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF156">
        <property type="entry name" value="INACTIVE TRNA-SPECIFIC ADENOSINE DEAMINASE-LIKE PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="4">
        <location>
            <begin position="377"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="42"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5470196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="545" mass="57992" checksum="AFFD9761666CFBA2" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KG86</accession>
    <name>A0A836KG86_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060724.1">
        <property type="nucleotide sequence ID" value="XM_067205172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KG86"/>
    <dbReference type="GeneID" id="92359106"/>
    <dbReference type="KEGG" id="loi:92359106"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5471607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="86" mass="9346" checksum="EE9A44647D0AEFFB" modified="2021-09-29" version="1">MRHIAFSPPAALQLFTPPCAAASRIVPSGNILSDGQLERRAMHQVKDASFVFLYQPLTLQTSIFAGETDREPGNDEAALRNPASVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KHY9</accession>
    <name>A0A836KHY9_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061485.1">
        <property type="nucleotide sequence ID" value="XM_067205548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KHY9"/>
    <dbReference type="SMR" id="A0A836KHY9"/>
    <dbReference type="GeneID" id="92359482"/>
    <dbReference type="KEGG" id="loi:92359482"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="913"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="466"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5473482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="980" mass="103344" checksum="10B73DFE55172218" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Leishmania orientalis</name>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
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                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    <dbReference type="KEGG" id="loi:92359329"/>
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        <location>
            <begin position="18"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="218"/>
        </location>
    </feature>
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        <location>
            <begin position="252"/>
            <end position="281"/>
        </location>
    </feature>
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        <location>
            <begin position="169"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5471830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="281" mass="29857" checksum="2FA41DEDE2155888" modified="2021-09-29" version="1">MPEQTTCATNTLQLLHAHVGSNPVTETKEQNGETALAERTPVAAAAPYDSALEAEEVARGSQEDWSQQPAEVQAQDAETQGDAVPAASSQVYMKMPEKVRARSRSSEAAPKPSGVCVFVRMPNDVRRKRALSRESGHNGVGSKPEESDMLYDTGKAVPPTAEEGRDTPEVQPAEVQQAEVQPAEPHDDNSAVQLNSERTADGYPATEASPATERVVEPDVNTEANSAELVGGATTAEMEAQENTSAAIATKAKDDAAPVEGGDARIEMKNDKEKARCCTVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KJ48</accession>
    <name>A0A836KJ48_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="8" type="ORF">LSCM4_05125</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG5476166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067207096.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="loi:92361030"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="MORN"/>
    </dbReference>
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        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43215">
        <property type="entry name" value="RADIAL SPOKE HEAD 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43215:SF14">
        <property type="entry name" value="RADIAL SPOKE HEAD 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="19"/>
    </dbReference>
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        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="7"/>
    </dbReference>
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        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="7">
        <location>
            <begin position="1739"/>
            <end position="1819"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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        </location>
    </feature>
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        </location>
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        <location>
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        </location>
    </feature>
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        <location>
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            <end position="1408"/>
        </location>
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        </location>
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        </location>
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        <location>
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        </location>
    </feature>
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        </location>
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        <location>
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        </location>
    </feature>
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        <location>
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        <location>
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        </location>
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        <location>
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        <source>
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        </source>
    </evidence>
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        </source>
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    <evidence type="ECO:0000256" key="6">
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5476166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="2421" mass="256694" checksum="BF9657BC3B1CF356" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KJG0</accession>
    <name>A0A836KJG0_9TRYP</name>
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        <recommendedName>
            <fullName evidence="3">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="4" type="ORF">LSCM4_05452</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5478054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067207393.1"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
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        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="3">
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            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5478054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="396" mass="42902" checksum="25E1CB81BFE7D2FC" modified="2021-09-29" version="1">MILEGAPVTGLTLLISTVSSTMVRGQYTRYRNMVFAADTLATPLASFTFAKRLLLQCIPIGPLGISAVDIFLTINLLYQFRTLERRWGSNSYMAFLLSSAMLGVCAVQLFITESGSKQLSVDAIRILSAAGTIVPLSALLTCHLREVPSRSALAVRIPGTNVTVSEKALALLPLLKLLLTPSTQLQAQTFRRAAVEVDVGVWSRLWFALIGAIFAMMSTRSGVVRWWLTVFTRYVCRPLLRFLRPLTDVLFGPSFTVDHAKPRRAQHQQGGNGSFHVGGSGTRVGFDGAEDAGVVDGGRYVVESLMGGDPLQEVRARMRARRHRVQQQQQGPLGGAVPGRAAFPARPRSQQEEAARNEAVSTIEAIGLHASRDEISAALDMAGGNLEMAVQILLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KJW2</accession>
    <name>A0A836KJW2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_04194</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062120.1">
        <property type="nucleotide sequence ID" value="XM_067206183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KJW2"/>
    <dbReference type="GeneID" id="92360117"/>
    <dbReference type="KEGG" id="loi:92360117"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46463:SF10">
        <property type="entry name" value="OS01G0926200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46463">
        <property type="entry name" value="ZINC FINGER, RING/FYVE/PHD-TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="216"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="93"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="174"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="348"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="379"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5475612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="415" mass="45275" checksum="88648B5DBD71F8E2" modified="2021-09-29" version="1">MMSTIESSNSPSRSSTSAEKPYVTDTTCSPVKANVVETNLIDSCDVEALESPQLPSLTSSSRGFRASVAFLSRMSKSEDPAEEGEHALASLTPVQRHHQQSDAAVSLSSSLPAQESQEMLSSTSLRVDGQHSISELPRTPHTTGSFGIFPSPLQQSMPLKWARTSVSLRSIMETPRSVEESVASTSLSETKPASKPPVARSSCGDSIALSEEGDMCCICLEEYTNENPMFRGACQHHFHLPCLMEWKQRSTLCPMCCAETLQGVGEFEALHHCVAADPAEVARQQDIAKRDAEIAQNLQHKYLRQAQRRDSHDARIAYALQSGSPRGSTSHTVPPAAEVSLRLPMTFQTENRGNSQRPGNIARVPSLRRPKRPEGVHQQRVTANGHSRATQPPVHPGIQGGQRSHRRLQPGCIVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KLL5</accession>
    <name>A0A836KLL5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aquaporin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_02922</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060494.1">
        <property type="nucleotide sequence ID" value="XM_067204942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KLL5"/>
    <dbReference type="SMR" id="A0A836KLL5"/>
    <dbReference type="GeneID" id="92358876"/>
    <dbReference type="KEGG" id="loi:92358876"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019755">
        <property type="term" value="P:one-carbon compound transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45665">
        <property type="entry name" value="AQUAPORIN-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45665:SF9">
        <property type="entry name" value="AQUAPORIN-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5470228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="30158" checksum="2D375A3A4D6E1FB5" modified="2021-09-29" version="1">MIPLQRDAAANGSGKPFLARQLPLLRLTRYQARFVCEGVGTFILLVTISLAEMNCGNLAVDGKAHTRNLAPIAEGFMLCVLIFMFGYISGGHFNPAVTFAVVMIRGMRVEEAMSYWVAQVLGALIGAGISILVNGTTRHLPAPQVVQNTAEYVFSAFVSEAVFTMLLVTVVLHVAYSQQRSNDYYGLAIGMCLLASQYAVGGVSGGAFNPAVATGLQVAKFIAAGYVTQLMYLWLYWAAPACGAVLAAFLFKMTHPVPKDEEDEAQQQQRVARNLYSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KM35</accession>
    <name>A0A836KM35_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin-like fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_05456</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5478057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062964.1">
        <property type="nucleotide sequence ID" value="XM_067207396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KM35"/>
    <dbReference type="GeneID" id="92361330"/>
    <dbReference type="KEGG" id="loi:92361330"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="GST_C_Metaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GST_N_Metaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF41">
        <property type="entry name" value="FAILED AXON CONNECTIONS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17172">
        <property type="entry name" value="GST_N_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin-like fold" evidence="2">
        <location>
            <begin position="105"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5478057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="382" mass="42541" checksum="A55500D83CF06138" modified="2021-09-29" version="1">MRLDCFEGIFDRPRQWMDNMASAARKRVTPQLHKEPPRLTPCQRRLAVGAAVVIGAITTYATLSRLFTFLERRRCWRLIRQCEARETKLFLFILPRSPWAPSLSPACTRVEMFLRANGIPYTAVETIGPLGAPNGGLPFLIYKRQRVDQLPKIMEFITSEFNVTMDDTLTRDERAMGASLRRALEYSVESLLYRIAFIDHPSLAVTQIARALHISHLRARLVVHGYAIHLRKQVAITAYGAFVSEQYENEFLQDCEAIEAQIGHKQYLFSDTTMTSYDCAVYSLLVPFACMGSHTSLSAAYSAVCDSTVLMAYIARISKQLFRDVSPGFDVAKISFATAATSGTGGATGETVMETVEEEEAKRQAVVDTLIGGAGSATVSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KMF7</accession>
    <name>A0A836KMF7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_06442</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000019">
        <property type="protein sequence ID" value="KAG5480874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063875.1">
        <property type="nucleotide sequence ID" value="XM_067208363.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92362297"/>
    <dbReference type="KEGG" id="loi:92362297"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053235">
        <property type="entry name" value="Ser_Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361">
        <property type="entry name" value="MITOGEN-ACTIVATED KINASE KINASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="721"/>
            <end position="1484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="644"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="1057"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1194"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1220"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1316"/>
            <end position="1414"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1035"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1194"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1227"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1249"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1323"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1367"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1389"/>
            <end position="1408"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="750"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5480874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1521" mass="159301" checksum="6C528B4EFD17D539" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KMH8</accession>
    <name>A0A836KMH8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dynein arm light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_05834</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063537.1">
        <property type="nucleotide sequence ID" value="XM_067207764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KMH8"/>
    <dbReference type="SMR" id="A0A836KMH8"/>
    <dbReference type="GeneID" id="92361698"/>
    <dbReference type="KEGG" id="loi:92361698"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00385">
        <property type="entry name" value="Isoprenoid_Biosyn_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019347">
        <property type="entry name" value="Axonemal_dynein_light_chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13183:SF1">
        <property type="entry name" value="ARM LIGHT CHAIN, AXONEMAL, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13183">
        <property type="entry name" value="AXONEMAL INNER ARM DYNEIN LIGHT CHAIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10211">
        <property type="entry name" value="Ax_dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5479826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="294" mass="33115" checksum="5615B15EBD806989" modified="2021-09-29" version="1">MNKCSNLRRNNSNAEGKGTFSSASVDDLQEAILQLLPRRASDRETAAYIDVDGPVDPNATLIRYDIPYAPGDPRRSLRLRKSLGRGAEERVVDPNVRVVIDSFITPRRWVDASTGVVWVQHASPFPSSRIEAAETQNRLHAQLEAHQARHTGTSPIRSLLVAECMLEVLRQVTAECWERGLLLLHVHSERVAAQAAHRRLFESRVGHAFRLALKGEKDVAKVEEDMAALRGRIELLGQEEADLRRMCSEFEQHAEEQVLIANKKHSDALTKLKREGVQKRTQLEQQLVIPAHLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KMX8</accession>
    <name>A0A836KMX8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7 9">Uracil-DNA glycosylase</fullName>
            <shortName evidence="7">UDG</shortName>
            <ecNumber evidence="3 7 9">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_07050</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7 9">Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7 9">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 9">Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="3 7 9"/>
    <dbReference type="EMBL" id="JAFHLR010000018">
        <property type="protein sequence ID" value="KAG5481339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064018.1">
        <property type="nucleotide sequence ID" value="XM_067208955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KMX8"/>
    <dbReference type="SMR" id="A0A836KMX8"/>
    <dbReference type="GeneID" id="92362889"/>
    <dbReference type="KEGG" id="loi:92362889"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097510">
        <property type="term" value="P:base-excision repair, AP site formation via deaminated base removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10027">
        <property type="entry name" value="UDG-F1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.470.10:FF:000001">
        <property type="entry name" value="Uracil-DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="entry name" value="Uracil-DNA glycosylase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00148">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002043">
        <property type="entry name" value="UDG_fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018085">
        <property type="entry name" value="Ura-DNA_Glyclase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003588">
        <property type="entry name" value="PRK05254.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003589">
        <property type="entry name" value="PRK05254.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003592">
        <property type="entry name" value="PRK05254.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00628">
        <property type="entry name" value="ung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264:SF0">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00987">
        <property type="entry name" value="UreE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00130">
        <property type="entry name" value="U_DNA_GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uracil-DNA glycosylase-like" evidence="11">
        <location>
            <begin position="198"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="21"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5481339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="380" mass="41840" checksum="35D2274F22FDABCE" modified="2021-09-29" version="1">MQKTLFDFVWRGRSSGVADAATVAAPGTERKRQLSSRSNDEDTALQAKTRREESRCRTSSREPEGDSKRGTSRDDAIDLDASVSVPLPESTRPQHERGGVVHEANHVFRGTAAPAGTATASSSGTNHSTAPPLQSFATSSRWLAGSITNAEWRDFLAPITADSWRNGAFIRIERFLDGEKEKGRVILPPAADIFNAFNSCPFRSLKVVLLGQDPYHDLRQAHGLCFSVLPDVPLPPSLRNIYKELATDIVGFQAPTHGYLQSWSQQGMLMLNATLTVEAHKANSHSKTSGWSSFTDAVIQHLSQHHPNRLVFLLWGGYAQQKKKLIDASRHVILESVHPSPLSANRGWFGCRCFSACNESLQAMGHSPMCWHLPLNAPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KPM8</accession>
    <name>A0A836KPM8_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061531.1">
        <property type="nucleotide sequence ID" value="XM_067205594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KPM8"/>
    <dbReference type="GeneID" id="92359528"/>
    <dbReference type="KEGG" id="loi:92359528"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="516"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5473528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="537" mass="58938" checksum="CE3730816381C679" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KPY1</accession>
    <name>A0A836KPY1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_04708</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000023">
        <property type="protein sequence ID" value="KAG5478475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063136.1">
        <property type="nucleotide sequence ID" value="XM_067206689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KPY1"/>
    <dbReference type="GeneID" id="92360623"/>
    <dbReference type="KEGG" id="loi:92360623"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF251">
        <property type="entry name" value="EG:BACR7C10.4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="510"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5478475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="880" mass="94116" checksum="D66AEF3B8B7BBF9A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KQM8</accession>
    <name>A0A836KQM8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 19">Leishmanolysin</fullName>
            <ecNumber evidence="5 19">3.4.24.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">LSCM4_03796</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Has an integral role during the infection of macrophages in the mammalian host.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>Preference for hydrophobic residues at P1 and P1' and basic residues at P2' and P3'. A model nonapeptide is cleaved at -Ala-Tyr-|-Leu-Lys-Lys-.</text>
            <dbReference type="EC" id="3.4.24.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18 19">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="18 19">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 19">Belongs to the peptidase M8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.36" evidence="5 19"/>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061729.1">
        <property type="nucleotide sequence ID" value="XM_067205792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KQM8"/>
    <dbReference type="SMR" id="A0A836KQM8"/>
    <dbReference type="GeneID" id="92359726"/>
    <dbReference type="KEGG" id="loi:92359726"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.132.10:FF:000001">
        <property type="entry name" value="leishmanolysin-like peptidase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.170.20:FF:000005">
        <property type="entry name" value="MSP-A1 surface protease homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.132.10">
        <property type="entry name" value="Leishmanolysin , domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.55.10">
        <property type="entry name" value="Leishmanolysin domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.34.10">
        <property type="entry name" value="Leishmanolysin domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001577">
        <property type="entry name" value="Peptidase_M8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10942">
        <property type="entry name" value="LEISHMANOLYSIN-LIKE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10942:SF0">
        <property type="entry name" value="LEISHMANOLYSIN-LIKE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01457">
        <property type="entry name" value="Peptidase_M8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00782">
        <property type="entry name" value="LSHMANOLYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 18 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 18 19" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 19" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 19" id="KW-0732">Signal</keyword>
    <keyword evidence="10 18 19" id="KW-0862">Zinc</keyword>
    <keyword evidence="14" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033105411" description="Leishmanolysin" evidence="19">
        <location>
            <begin position="24"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="active site" evidence="17">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR601577-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR601577-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU366077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAG5474623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="567" mass="59754" checksum="3F0724B042C6BB82" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KQZ0</accession>
    <name>A0A836KQZ0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ribonuclease</fullName>
            <ecNumber evidence="12">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LSCM4_07845</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">LSCM4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 12">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11 12">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the RNase HII family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="12"/>
    <dbReference type="EMBL" id="JAFHLR010000013">
        <property type="protein sequence ID" value="KAG5484279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064772.1">
        <property type="nucleotide sequence ID" value="XM_067209722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KQZ0"/>
    <dbReference type="SMR" id="A0A836KQZ0"/>
    <dbReference type="GeneID" id="92363656"/>
    <dbReference type="KEGG" id="loi:92363656"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07182">
        <property type="entry name" value="RNase_HII_bacteria_HII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022898">
        <property type="entry name" value="RNase_HII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF23">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51975">
        <property type="entry name" value="RNASE_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11 12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11 12" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-2" evidence="13">
        <location>
            <begin position="16"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG5484279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="308" mass="33236" checksum="2C28D3CCBCC51302" modified="2021-09-29" version="1">MNTTEKDGAGLRPTIRYVIGVDEAGRGCMAGPVGVAATLYRITTTPVRYTVMDSKRMKDRARAETLKAMCAELSDASVEDFLRTTMRDGACCLVRYQHRQPLQAMSVALVDVAVINERNILNATLEGMSAVCDAIVRSYNAMRGLGALTPLTCAILIDGNRVPWTFLSSEDRQRVRVQARRKVEARKRIGVEYPVLDGFGSTTVVKGDATMLSIAAASIVAKVVRDAYATAVMHCAFPQYGFDQHKGYCTAAHELELARWGPSPFHRLDYAPVRAVVESRAAGQQTPSCIAERAGPCASSNGAATGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KS58</accession>
    <name>A0A836KS58_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_06026</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000011">
        <property type="protein sequence ID" value="KAG5485389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065126.1">
        <property type="nucleotide sequence ID" value="XM_067207952.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836KS58"/>
    <dbReference type="GeneID" id="92361886"/>
    <dbReference type="KEGG" id="loi:92361886"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00106">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF15">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="24"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="532"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="885"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="986"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1205"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1314"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1371"/>
            <end position="1406"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="474"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="655"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="731"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="553"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="576"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="595"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="614"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="918"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1013"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1068"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1223"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1249"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1314"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1376"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1391"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="127"/>
            <end position="134"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5485389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1488" mass="155053" checksum="74D7535DC538C7E8" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KSH5</accession>
    <name>A0A836KSH5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Endoplasmic reticulum vesicle transporter C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_05934</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000011">
        <property type="protein sequence ID" value="KAG5485301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065038.1">
        <property type="nucleotide sequence ID" value="XM_067207864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KSH5"/>
    <dbReference type="SMR" id="A0A836KSH5"/>
    <dbReference type="GeneID" id="92361798"/>
    <dbReference type="KEGG" id="loi:92361798"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF27">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="442"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="7">
        <location>
            <begin position="104"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="6">
        <location>
            <begin position="258"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5485301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="475" mass="54042" checksum="234E6C07B1650863" modified="2021-09-29" version="1">MQHLQKRIREGEMKERRLIEMIAARELEAGTPLHESEFLEIIRNSQQQLTAFYEDKLSLMQSEMERFFAHSAACIREKDTIIGALKKEKAEPQVSRTRISRHIAKVDMFPKPREDYQREQTRVGAFLSMSTVCIVVLLVMWEGIAYWRGRDAYDTDVSLDKGLSDQMPVHFDVLFPFMSCKRLSIDVVDATGMARLNCTGTIHKLPTTLQGELQYKGSMEDLYNEIEVDGVRTDRKCRRCPLSALHGVAAEIRNSAVSKCCDTCDSVLDLYRELEKDFPGFEYIPQCLDKLLEGASGCNVIGSLNLKKVPVTVIFGPRRTGRLYSLKDVLRLDTSHVIKKLRIGDEAVDRFSEHGVAEPLSGHKSSSKTYSETRYLVKVVPTTYRTKKVKDVKASTYEYSAQWSRRAILVGFSGAVPAVLFRFEPAAIQVNNVFEREPFSHFLVQLCGIVGGLFVVLGLIDRAVEWCVHFEKRQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KT64</accession>
    <name>A0A836KT64_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histone RNA hairpin-binding protein RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_04541</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">LSCM4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SLBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062734.1">
        <property type="nucleotide sequence ID" value="XM_067206525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KT64"/>
    <dbReference type="SMR" id="A0A836KT64"/>
    <dbReference type="GeneID" id="92360459"/>
    <dbReference type="KEGG" id="loi:92360459"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071204">
        <property type="term" value="C:histone pre-mRNA 3'end processing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071207">
        <property type="term" value="F:histone pre-mRNA stem-loop binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006398">
        <property type="term" value="P:mRNA 3'-end processing by stem-loop binding and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1120:FF:000001">
        <property type="entry name" value="Histone RNA hairpin-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1120">
        <property type="entry name" value="Histone RNA hairpin-binding protein RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026502">
        <property type="entry name" value="SLBP1/SLBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029344">
        <property type="entry name" value="SLBP_RNA_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038294">
        <property type="entry name" value="SLBP_RNA_bind_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17408">
        <property type="entry name" value="HISTONE RNA HAIRPIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17408:SF0">
        <property type="entry name" value="HISTONE RNA HAIRPIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15247">
        <property type="entry name" value="SLBP_RNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Histone RNA hairpin-binding protein RNA-binding" evidence="4">
        <location>
            <begin position="482"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="169"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="238"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="329"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="583"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="893"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="281"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="381"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="597"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="901"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="945"/>
            <end position="991"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5477323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="991" mass="102885" checksum="7297E809295618B7" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KUA0</accession>
    <name>A0A836KUA0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ubiquitin-activating enzyme E1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_04681</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000023">
        <property type="protein sequence ID" value="KAG5478448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063109.1">
        <property type="nucleotide sequence ID" value="XM_067206662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KUA0"/>
    <dbReference type="SMR" id="A0A836KUA0"/>
    <dbReference type="GeneID" id="92360596"/>
    <dbReference type="KEGG" id="loi:92360596"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004839">
        <property type="term" value="F:ubiquitin activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01490">
        <property type="entry name" value="Ube1_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.180:FF:000007">
        <property type="entry name" value="Putative ubiquitin-activating enzyme e1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12550:FF:000005">
        <property type="entry name" value="Putative ubiquitin-activating enzyme e1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.80:FF:000002">
        <property type="entry name" value="SUMO-activating enzyme subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.80:FF:000007">
        <property type="entry name" value="Ubiquitin-activating enzyme E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2660:FF:000005">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.180">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, FCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.80">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12550">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2660">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, SCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.60">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, UFD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042302">
        <property type="entry name" value="E1_FCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018965">
        <property type="entry name" value="Ub-activating_enz_E1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042449">
        <property type="entry name" value="Ub-E1_IAD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038252">
        <property type="entry name" value="UBA_E1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019572">
        <property type="entry name" value="UBA_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042063">
        <property type="entry name" value="Ubi_acti_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018075">
        <property type="entry name" value="UBQ-activ_enz_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000011">
        <property type="entry name" value="UBQ/SUMO-activ_enz_E1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01408">
        <property type="entry name" value="Ube1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF4">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09358">
        <property type="entry name" value="E1_UFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10585">
        <property type="entry name" value="UBA_E1_SCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01849">
        <property type="entry name" value="UBIQUITINACT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00985">
        <property type="entry name" value="UBA_e1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-activating enzyme E1 C-terminal" evidence="9">
        <location>
            <begin position="909"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5478448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1044" mass="115412" checksum="3831A9113EB5D69B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KVY2</accession>
    <name>A0A836KVY2_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_07605</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the APH-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000012">
        <property type="protein sequence ID" value="KAG5484835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064947.1">
        <property type="nucleotide sequence ID" value="XM_067209487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KVY2"/>
    <dbReference type="GeneID" id="92363421"/>
    <dbReference type="KEGG" id="loi:92363421"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009294">
        <property type="entry name" value="Aph-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12889">
        <property type="entry name" value="GAMMA-SECRETASE SUBUNIT APH-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="378"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5484835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="461" mass="48527" checksum="6BD4C4D7631F6899" modified="2021-09-29" version="1">MDCGTLVLCTSVLYAPHAVLCGLALLWQPMLMVMSLVASFVAFVPFVVTGVVFQTLRWADIGVVTHAVWVVAIHFVLQNIARVGALHVCLRLQRLGLRHGLLLVRSCFPLVPLSIAVGAGFAASSLLVSGGALLSEAWGVGSRLSDNGRASATSTVARQEIGLFASSGNCARLPLIVQSCFQQTFFSCGQVAWTVMMGQAYAALYPQNAAEDLLGHTVRANDADDAAAISVETATEAEEDGSAPAARALRAKEETVRQDAAELLLADGDFVPVLRDNKRETAVRIARRGHASTGAQPMPREEAAVNQPVPCNTVDSESCGAGTLTDTAPSVAPFISEATRAPTVAQRRGMPASASPVAAAARWRVAGSVLEQQLPTAALTGAAALVLHLVFVLLPLTEVVADSASAQNMSIPFSGRGSSRCLFSIPLQCAVTLVSVVWGLWIVELERHPSAYTLLQSPPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KXU3</accession>
    <name>A0A836KXU3_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000007">
        <property type="protein sequence ID" value="KAG5486875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065669.1">
        <property type="nucleotide sequence ID" value="XM_067208264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KXU3"/>
    <dbReference type="GeneID" id="92362198"/>
    <dbReference type="KEGG" id="loi:92362198"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5486875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="321" mass="34462" checksum="7FDB4A8F0822EFB6" modified="2021-09-29" version="1">MSSPAARVPAGASFPATRAASPGAHPSSASASAASARTHLLLPPQQQTNSRCGGNDAHARQLAREQQQMIEQLTSTGLVQAADLLEFGFSAAELRAAGLHLSSPHHRANEQAESRGEATKTERLADGSNDDRRRRGVPRKRAWGCVATQASPPQDERATPSPAVSGTATTALSTVEKTREPQTIAKAVVTPLLLSEKTRKQCLHAAKLVEDAQIMRPFKDSQDCARWLCYDDADEEEASSTSATGSSSGDATVAVTSKVHSMRDPPKARCNTALAFSGLDVAVVREIAQRLQEESSHDAYVESRRTREYFSLREDGNTPYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KY56</accession>
    <name>A0A836KY56_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine zipper transcription factor-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_07723</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Self-associates. Interacts with BBS9; the interaction mediates the association of LZTL1 with the BBsome complex and regulates BBSome ciliary trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LZTFL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000006">
        <property type="protein sequence ID" value="KAG5487235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065732.1">
        <property type="nucleotide sequence ID" value="XM_067209602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KY56"/>
    <dbReference type="SMR" id="A0A836KY56"/>
    <dbReference type="GeneID" id="92363536"/>
    <dbReference type="KEGG" id="loi:92363536"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903565">
        <property type="term" value="P:negative regulation of protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026157">
        <property type="entry name" value="LZTFL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21635">
        <property type="entry name" value="LEUCINE ZIPPER TRANSCRIPTION FACTOR LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21635:SF0">
        <property type="entry name" value="LEUCINE ZIPPER TRANSCRIPTION FACTOR-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15294">
        <property type="entry name" value="Leu_zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="140"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5487235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="278" mass="30751" checksum="DDA2A501D42EE617" modified="2021-09-29" version="1">MDPFSGLSSESRNVIDDFFRWSRLSLDKFKRDLAVEASAFQSGNLLREQHTKAEVSQMLNGQLALLLGVMDTQMEGTTAASAELMRAVLREADRQRLGLSIDVKTVLNNAGGVNAMGEHGRQLLSGPAGRLAPLTLEAAGGEAARQLAEANTEVRRLQRKLQQVTDAYTQVMSGRSSDTATLLSMQDAMNDKERLAAELARRCQGQDPSLTAVVQELRAEVAEAKRELATRLHQSTQYQQVKQLLAQRNEQLKEMRERLAAYDPSFVRYGDDIAAEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KYZ2</accession>
    <name>A0A836KYZ2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">thioredoxin-dependent peroxiredoxin</fullName>
            <ecNumber evidence="2">1.11.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_07282</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="2"/>
    <dbReference type="EMBL" id="JAFHLR010000015">
        <property type="protein sequence ID" value="KAG5483068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064564.1">
        <property type="nucleotide sequence ID" value="XM_067209181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KYZ2"/>
    <dbReference type="SMR" id="A0A836KYZ2"/>
    <dbReference type="GeneID" id="92363115"/>
    <dbReference type="KEGG" id="loi:92363115"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03015">
        <property type="entry name" value="PRX_Typ2cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000003">
        <property type="entry name" value="Peroxiredoxin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050217">
        <property type="entry name" value="Peroxiredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF171">
        <property type="entry name" value="PEROXIREDOXIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681">
        <property type="entry name" value="THIOREDOXIN PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7 9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="6"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="10">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5483068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="189" mass="21245" checksum="70D40A4BA06C5172" modified="2021-09-29" version="1">MSCGDAKMNHPAPEFNEVALMPNGTFKNITLSSYKGKWVVLFFYPLDFSFVCPTEIIQFSDNMCRFKDLNCEVIACSMDSEYAHLQWTSQDRKKGGLGPMEIPMLADKTKSISRAYGVLEESKGVAYRGVFIIDPKGILRQITINDMPVGRNVDEVLRLLEALQFVEKHGEVCPANWKKGDPGLKVNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KZQ6</accession>
    <name>A0A836KZQ6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Membrane-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_04958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000014">
        <property type="protein sequence ID" value="KAG5483803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064742.1">
        <property type="nucleotide sequence ID" value="XM_067206933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KZQ6"/>
    <dbReference type="GeneID" id="92360867"/>
    <dbReference type="KEGG" id="loi:92360867"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032941049" description="Membrane-associated protein" evidence="1">
        <location>
            <begin position="37"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5483803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="201" mass="20949" checksum="7B8837678A36A243" modified="2021-09-29" version="1">MSSSTRASRLVAFTAAAGFLLLLLLVTPCSLTTAYAAASVADFRKAYQVIMESAGEGFGAFYRDMTQPPASSEWECTTGLSTAFSVAYASATAPYTLSVLSSTLTVTRSSVTSGVSYDLIGISCAYDAACGDMMRGSSLSFPLTAGHVVIVAGSITSNGIVNFMPVSFYVIQPASACSSAHIANVTRAFTGTSAVWMQLWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836L235</accession>
    <name>A0A836L235_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000009">
        <property type="protein sequence ID" value="KAG5486038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065369.1">
        <property type="nucleotide sequence ID" value="XM_067208658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836L235"/>
    <dbReference type="SMR" id="A0A836L235"/>
    <dbReference type="GeneID" id="92362592"/>
    <dbReference type="KEGG" id="loi:92362592"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="614"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="732"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="614"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="644"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="745"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5486038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="768" mass="86688" checksum="B9A72472186F7B14" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836L409</accession>
    <name>A0A836L409_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Surface antigen-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_07471</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5472872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="268" mass="30219" checksum="DE35ED34F1D8D4D5" modified="2021-09-29" version="1">MRVSLLRRFCEYVPKGASSKVSRSAATPRGVTRAFRVTEMAAAAADAERDAKGFFYLPRIDYDVGHGVAPLMSRKQFDVQYHVFHKAAVDRLNAHTLGSELEGHNLNVVIRNSSFDASRAVVHAAASEHFNYCFWYRSLRPWGTTVPARLKDELQLQYSQNGSLDAVEEVQRLFTVTALSQQYAGGWVYLVWTGKAFDVLSFDHGTCPIGSDLIPLLALNMHESARCYDYPLLAEDDDGDEIERFVRNFFKACNWGLAEQYFLQCGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G1Y7</accession>
    <name>A0A836G1Y7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Choline/carnitine acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_03586</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061520.1">
        <property type="nucleotide sequence ID" value="XM_067205583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G1Y7"/>
    <dbReference type="SMR" id="A0A836G1Y7"/>
    <dbReference type="GeneID" id="92359517"/>
    <dbReference type="KEGG" id="loi:92359517"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004095">
        <property type="term" value="F:carnitine O-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF60">
        <property type="entry name" value="O-PALMITOYLTRANSFERASE II, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00439">
        <property type="entry name" value="ACYLTRANSF_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="4">
        <location>
            <begin position="19"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5473517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="627" mass="68548" checksum="68C8FD0F5B2B31A5" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G215</accession>
    <name>A0A836G215_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PIH1D1/2/3 CS-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_03631</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PIH1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061565.1">
        <property type="nucleotide sequence ID" value="XM_067205628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G215"/>
    <dbReference type="SMR" id="A0A836G215"/>
    <dbReference type="GeneID" id="92359562"/>
    <dbReference type="KEGG" id="loi:92359562"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070286">
        <property type="term" value="P:axonemal dynein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026697">
        <property type="entry name" value="DNAAF6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041442">
        <property type="entry name" value="PIH1D1/2/3_CS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21083:SF0">
        <property type="entry name" value="DYNEIN AXONEMAL ASSEMBLY FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21083">
        <property type="entry name" value="TWISTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18201">
        <property type="entry name" value="PIH1_CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIH1D1/2/3 CS-like" evidence="3">
        <location>
            <begin position="171"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="16"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5473562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="280" mass="29843" checksum="66098B1682591AA9" modified="2021-09-29" version="1">MTMNASDLESLASMLDSNRTFKRPEGQATGFSLEEQPSSTTPEAYASGGTMLISSGDSGVAPLQPQGNPAGIALPPTVVDHQLRLPQPSHGKEAERKKQLAQPARPSGDEIWTQAELTALLMRQRKDGPAPVAAAARVAAQQASARSADGQPRAATLWQPRPSDAGTFEEPVHTVLYQQHVSAEDVYLGVDFTRDASSAASDGVTVRVEMPRVTSVHEIAMDIDAYELRVSVAGVYYLAAPLPRRVQKTAADAAWDAQKKLLTVCLKADNSMGNDVTIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G3Q7</accession>
    <name>A0A836G3Q7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Chaperonin HSP60, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">groEL protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_00210</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058400.1">
        <property type="nucleotide sequence ID" value="XM_067202299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G3Q7"/>
    <dbReference type="SMR" id="A0A836G3Q7"/>
    <dbReference type="GeneID" id="92356233"/>
    <dbReference type="KEGG" id="loi:92356233"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000001">
        <property type="entry name" value="60 kDa chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000592">
        <property type="entry name" value="PRK00013.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009487">
        <property type="entry name" value="PRK12849.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009488">
        <property type="entry name" value="PRK12850.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009489">
        <property type="entry name" value="PRK12851.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45633">
        <property type="entry name" value="60 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00080006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5464769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="568" mass="60473" checksum="FD2F27BF635D5425" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G5R7</accession>
    <name>A0A836G5R7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Intraflagellar transport protein 43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_04276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062200.1">
        <property type="nucleotide sequence ID" value="XM_067206263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G5R7"/>
    <dbReference type="SMR" id="A0A836G5R7"/>
    <dbReference type="GeneID" id="92360197"/>
    <dbReference type="KEGG" id="loi:92360197"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="297"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="346"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5475692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="424" mass="44743" checksum="78CB098321426E91" modified="2021-09-29" version="1">MASTGNGGGKSAAALLPAPLQAENMQSLSSAPNMIGLNTSLSRLDSMRAMSPSVCGQNSPTGSSKRGTVMESPFSFDADGKAAANSSAPRPLESASTDRNRKSNASGVNATTAADGSGSSSKTRTVHGRRGRRREASNWFDSDKPTNINRPADTELNQDVRIVHDDLTDLEQVRREQAERAQRQKEQLAQHVSESPAGYHATLPRLNELDVTNNWDKLLRTMRNEYDMSCLTSCLSRELDEDVAWNPEMLLVQLTSDMLDAAEMQKDGGEAYVPVDASDIGQMTGGEVTRKRKEKGATTAAPTTSSPTTGEAAREPAKKSEKTAAAPPPPSLQATTSKALRVQTTAASAAAALSSKDANKADKSGATSRANSPSKRNRTAVDSRSGESGVGGGNNTRAPSSKARHASARGTAAKQPATKLFSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G6M0</accession>
    <name>A0A836G6M0_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062435.1">
        <property type="nucleotide sequence ID" value="XM_067207132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G6M0"/>
    <dbReference type="GeneID" id="92361066"/>
    <dbReference type="KEGG" id="loi:92361066"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5476202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="474" mass="51911" checksum="6A5F00773858B013" modified="2021-09-29" version="1">MLRPSRPLRRSIDEQRREGGSSESAKGFLMSRRIGRRTHAASTLFTTASAGGCTTMAPAGPAAVANAEAMSAVPLPSLVSCSDGVCNASDLRGVHPPQRLTSSFPTTAADTVDAAAAVRKSAESYTYGPSKHASSPLKVATTHYTGLNVLFDRTDKQPHIPKSGPRLFTSTEVLELRSEARQAYARRRRMEERRQLIASEAEARSGLAGAALDQIAAVRELHKEERESLMRAASDAALPVQCLEQRIRHRIIEEDAKSDGQLRQEGRDAWRLHVQLCKEASEDLSARVVAHRAATHRFRAALTFIVVQEIELRKCVEVESAKCWEALVQEEAEGRADAERRALVRFLSSPEQLALTAAREERERKRARRTAKLLRLFQEQQDGFVNGCRHGTGGLSLFVGGAPKKVCRRCRVKWDENLGYYVSMDRTMKIHSPPSPLTAAVGAGVKTAPPAVKQSVAEAAKGVSVLPPLKERST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G8M5</accession>
    <name>A0A836G8M5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ras-related protein rab-2a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_02885</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060457.1">
        <property type="nucleotide sequence ID" value="XM_067204905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G8M5"/>
    <dbReference type="SMR" id="A0A836G8M5"/>
    <dbReference type="GeneID" id="92358839"/>
    <dbReference type="KEGG" id="loi:92358839"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01866">
        <property type="entry name" value="Rab2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000263">
        <property type="entry name" value="Ras-related protein RABB1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000020">
        <property type="protein sequence ID" value="KAG5480372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063703.1">
        <property type="nucleotide sequence ID" value="XM_067208063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GE80"/>
    <dbReference type="GeneID" id="92361997"/>
    <dbReference type="KEGG" id="loi:92361997"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="245"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5480372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="618" mass="64255" checksum="AA8D0886755FF38E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GGG0</accession>
    <name>A0A836GGG0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Glycerol-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="3 7">1.1.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_03759</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a quinone + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:18977"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.1.5.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.5.3" evidence="3 7"/>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061692.1">
        <property type="nucleotide sequence ID" value="XM_067205755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GGG0"/>
    <dbReference type="SMR" id="A0A836GGG0"/>
    <dbReference type="GeneID" id="92359689"/>
    <dbReference type="KEGG" id="loi:92359689"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004368">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.870">
        <property type="entry name" value="Alpha-glycerophosphate oxidase, cap domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031656">
        <property type="entry name" value="DAO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038299">
        <property type="entry name" value="DAO_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985:SF15">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16901">
        <property type="entry name" value="DAO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01001">
        <property type="entry name" value="FADG3PDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00977">
        <property type="entry name" value="FAD_G3PDH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00978">
        <property type="entry name" value="FAD_G3PDH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="8">
        <location>
            <begin position="69"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-glycerophosphate oxidase C-terminal" evidence="9">
        <location>
            <begin position="471"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5474586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="608" mass="66468" checksum="2B702F44CD90B17A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GGL1</accession>
    <name>A0A836GGL1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Actin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_00357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058541.1">
        <property type="nucleotide sequence ID" value="XM_067202440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GGL1"/>
    <dbReference type="SMR" id="A0A836GGL1"/>
    <dbReference type="GeneID" id="92356374"/>
    <dbReference type="KEGG" id="loi:92356374"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5464910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="407" mass="44170" checksum="A0BA02C907463AAF" modified="2021-09-29" version="1">MPSVSTSVESVVVDVGSRDTRIGFSGEEAPRTTLRSCVGLPRPKRPRPTLLQHSFDIVAGDAAYKDDGLLELVFPVRAGHVYDYDAFEKLLFYAFVEEARITPDVSQFLFLEPADQSRLSRERLCEVLFESFNIPLAGLLTNTAATLYSSGRTSGLALDSGAGRTCVAAVEEGYTLAYSVRSSPIAGEALTDELFAALRADGYPLSTAADRDVVEAAKKALCRVSADAKDEEARQVGMRDHPDPADGFVLPDQERLFLLEHAYKVPEALFDNTYLTYTTAISAERPTTPTGYSQSNPAVKRSLCGWVDMLRDAATAAPRLLRQVLYENVVLGGGNTLLRGTEERLQREIAAIAPKGAQATCVAFPERGAAAWMGASIWGCSSVFPDTCLSKATYDEQGSSVVHRYTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GJP8</accession>
    <name>A0A836GJP8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glycosyl hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_00560</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 65 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058739.1">
        <property type="nucleotide sequence ID" value="XM_067202638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GJP8"/>
    <dbReference type="SMR" id="A0A836GJP8"/>
    <dbReference type="GeneID" id="92356572"/>
    <dbReference type="KEGG" id="loi:92356572"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000079">
        <property type="entry name" value="Putative glycosyl hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.40">
        <property type="entry name" value="Glycoside hydrolase, family 65, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.420.10">
        <property type="entry name" value="Maltose phosphorylase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037018">
        <property type="entry name" value="GH65_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005194">
        <property type="entry name" value="Glyco_hydro_65_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005195">
        <property type="entry name" value="Glyco_hydro_65_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005196">
        <property type="entry name" value="Glyco_hydro_65_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11051">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11051:SF8">
        <property type="entry name" value="PROTEIN-GLUCOSYLGALACTOSYLHYDROXYLYSINE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03633">
        <property type="entry name" value="Glyco_hydro_65C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03632">
        <property type="entry name" value="Glyco_hydro_65m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03636">
        <property type="entry name" value="Glyco_hydro_65N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 65 N-terminal" evidence="6">
        <location>
            <begin position="43"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 65 central catalytic" evidence="4">
        <location>
            <begin position="450"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 65 C-terminal" evidence="5">
        <location>
            <begin position="818"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="62"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="302"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="332"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5465108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1154" mass="128451" checksum="058B5551479B96BA" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GJU6</accession>
    <name>A0A836GJU6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_00636</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058814.1">
        <property type="nucleotide sequence ID" value="XM_067202713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GJU6"/>
    <dbReference type="GeneID" id="92356647"/>
    <dbReference type="KEGG" id="loi:92356647"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019396">
        <property type="entry name" value="TM_Fragile-X-F-assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10269">
        <property type="entry name" value="Tmemb_185A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="342"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="591"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="517"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="607"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5465183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="634" mass="70681" checksum="84441A1AB4135EA5" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GLI6</accession>
    <name>A0A836GLI6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Beta galactofuranosyl glycosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_00809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059532.1">
        <property type="nucleotide sequence ID" value="XM_067202882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GLI6"/>
    <dbReference type="GeneID" id="92356816"/>
    <dbReference type="KEGG" id="loi:92356816"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5467730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="256" mass="28164" checksum="368BD00FA0A8C2D7" modified="2021-09-29" version="1">MVATHPLKKRLRCGRRGGTLLAVSALFLTVVSILVLTELLELGSEVISLAPFLDASDPETAPQPARTPPGHLHSYLDCLAARINVDRHTGTERPFPDDDISVPYMVLPVTIEEKLMMSLMCNLTVHIRHIVYVQNGAVPSMTAFLGAVTAALNFTQRVRVMHKPGNFGYAAALNMAARDFLKLPFDEAPFFLMANNDVLLPGGMMEEALPLFYNASRAGRGMLDELEAEVAAEPNEHTPQHFRDVRCAPRTVATCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GLK6</accession>
    <name>A0A836GLK6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA replication licensing factor MCM2</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LSCM4_03828</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061760.1">
        <property type="nucleotide sequence ID" value="XM_067205823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GLK6"/>
    <dbReference type="SMR" id="A0A836GLK6"/>
    <dbReference type="GeneID" id="92359757"/>
    <dbReference type="KEGG" id="loi:92359757"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000024">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008045">
        <property type="entry name" value="MCM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF44">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12619">
        <property type="entry name" value="MCM2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01658">
        <property type="entry name" value="MCMPROTEIN2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="13">
        <location>
            <begin position="496"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="732"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="67"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="168"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG5474654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="971" mass="110256" checksum="D0D30FD7EDCAFA18" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GM17</accession>
    <name>A0A836GM17_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5468015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059817.1">
        <property type="nucleotide sequence ID" value="XM_067203167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GM17"/>
    <dbReference type="GeneID" id="92357101"/>
    <dbReference type="KEGG" id="loi:92357101"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5468015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="497" mass="52603" checksum="65E7262B6D021ADC" modified="2021-09-29" version="1">MVLPPALHLGPHALRILPACRSAEVAPSMRGCSDSLLTAFCFVGELQTDAVDVSGEVSDAARDSTSRGASIVWYYSPLFQYERKRIRVEEGVIEASLTRAVEASQHADVNSPSLHLGGAKTAEYEGSRPARLSEASSAALSVTSATALPALYLRVGSSTTFREYGLVVAELQRAGQGASAEPCMQSRANTVGGDGDRSAHAAQKPPVFLRLTPNRPTLKPIDTQRSGSDLQNMRRLTHRRNTAPRGDATLLSVSAQRSAAQMQDGVRSSPWPSSLSEVATTATLGASLLRSESDRGNKPDGATFSMPVSLFREEDESSARTSQEGGSSKRVLRVEQRVKPEECARKDVPHGSHPFDGAGGSNISSALFSNSVFSSLPFQAPSSVLSTMGTPETDTDDCRSCSTAASGLGGGVLDNAHLRSLEITYLAFDAFTSLAQSPSYPTPPAAPKPRFVRRLPLCTYVNNSGFELATLAPLASAAQGIRLELEPAIAAAPQSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GNV1</accession>
    <name>A0A836GNV1_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_04989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062267.1">
        <property type="nucleotide sequence ID" value="XM_067206964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GNV1"/>
    <dbReference type="GeneID" id="92360898"/>
    <dbReference type="KEGG" id="loi:92360898"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5476034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="267" mass="28539" checksum="73C37D2B72571765" modified="2021-09-29" version="1">MDVSQFLKSFKKNVAAKARLDASLQHTAEATGAGGDEDVMDILHSASDDEANGEAENGEAIRGRRADMMAGKRYAASATHLKRNQEFAALKVVETNSAPTVEAGRFQRQRATLALQARDTRKLPRIEMVASVRAELLRKREQLQSSHALDPAGLVAAPIQKVEEMMLQVDDLLQDSSPTGIPSAATLDFLPAASPPAGPQSTPTATSSALFAGGAPDEPEEPPSLVRNKTVVSSSSKEARAEEPPVLPKKRSKFEIAMTLARDDEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GNW4</accession>
    <name>A0A836GNW4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cilia- and flagella-associated protein 251</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_04517</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">LSCM4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062710.1">
        <property type="nucleotide sequence ID" value="XM_067206501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GNW4"/>
    <dbReference type="GeneID" id="92360435"/>
    <dbReference type="KEGG" id="loi:92360435"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050630">
        <property type="entry name" value="WD_repeat_EMAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13720:SF13">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 251"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13720">
        <property type="entry name" value="WD-40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="750"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1136"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="750"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="765"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5477299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1171" mass="125802" checksum="B88CCF2D346FD76D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GP07</accession>
    <name>A0A836GP07_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_05080</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062357.1">
        <property type="nucleotide sequence ID" value="XM_067207054.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836GP07"/>
    <dbReference type="GeneID" id="92360988"/>
    <dbReference type="KEGG" id="loi:92360988"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000955">
        <property type="entry name" value="Protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="956"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="205"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="389"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="564"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="624"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
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            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="758"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="566"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="577"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="627"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="764"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="993"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5476124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1392" mass="148092" checksum="5EDCC0674487B520" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GP41</accession>
    <name>A0A836GP41_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_02553</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
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        <lineage>
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            <taxon>Euglenozoa</taxon>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5469155.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="954" mass="97190" checksum="C08D8D04360CA1B7" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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            <dbReference type="EMBL" id="KAG5477989.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
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    </evidence>
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</entry>
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                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">LSCM4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="2"/>
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        <property type="protein sequence ID" value="KAG5470040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067204754.1"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
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        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
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        <property type="entry name" value="SUPEROXIDE DISMUTASE"/>
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    </dbReference>
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        <property type="entry name" value="SUPEROXIDE DISMUTASE"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    <proteinExistence type="inferred from homology"/>
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        </location>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
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            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5470040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5470255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="313" mass="36544" checksum="12B6A6AA37064498" modified="2021-09-29" version="1">MLRRAYAPAMCMGGVLGSVVGGPEASSSFFAAAHMVTGRTGLVMHTPKADVQMGRFNFADQYNEFRNRSGRAPDYYVDKYRKTYWRVDEYIRRSESYIQSQGFFYLPTLEFPWYKGCMPLMSSYQIRVHYGRHHRAYVERLNQLIEGTPLYGMQLDAVIVKSSNDSHLKGVYNNAAQHYNHSFFWKCIQPYGSNIPPDLSAAVCAQYGSVSNFEKQFITAAQNLFGSGWVYWVYDKKASAFDIVSYSNAGCPLTSYEYTPLLCVDVWEHAYYIDYENKRPEYLSKYFDVVDWHWAERHWKRATGQEYYEMKFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="3">NPHP4 Ig-like domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="4" type="ORF">LSCM4_04558</name>
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        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Trypanosomatidae</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067206541.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92360475"/>
    <dbReference type="KEGG" id="loi:92360475"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
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        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097730">
        <property type="term" value="C:non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058685">
        <property type="entry name" value="Ig_NPHP4_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029775">
        <property type="entry name" value="NPHP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31043">
        <property type="entry name" value="NEPHROCYSTIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31043:SF3">
        <property type="entry name" value="NEPHROCYSTIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26187">
        <property type="entry name" value="Ig_NPHP4_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NPHP4 Ig-like" evidence="3">
        <location>
            <begin position="1249"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="269"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="413"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="880"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="413"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="425"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="435"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="469"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="480"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5477339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1341" mass="145424" checksum="97DF05474C642480" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GRV1</accession>
    <name>A0A836GRV1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_02141</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061213.1">
        <property type="nucleotide sequence ID" value="XM_067204176.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="loi:92358110"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000641">
        <property type="term" value="P:regulation of early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000007">
        <property type="entry name" value="DnaJ (Hsp40) homolog, subfamily C, member 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044978">
        <property type="entry name" value="GRV2/DNAJC13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045802">
        <property type="entry name" value="GRV2/DNAJC13_N"/>
    </dbReference>
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        <property type="entry name" value="GYF_2"/>
    </dbReference>
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        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36983:SF2">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 13"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1383"/>
            <end position="1437"/>
        </location>
    </feature>
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        <location>
            <begin position="2120"/>
            <end position="2139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2426"/>
            <end position="2445"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2058"/>
            <end position="2108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5472817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="2445" mass="272547" checksum="E84D9DEABE00F9A5" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GT80</accession>
    <name>A0A836GT80_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">4-coumarate--CoA ligase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_06471</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000019">
        <property type="protein sequence ID" value="KAG5480901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063902.1">
        <property type="nucleotide sequence ID" value="XM_067208390.1"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A836GT80"/>
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    <dbReference type="KEGG" id="loi:92362324"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
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        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
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        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
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        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
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        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AMP-binding_C"/>
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    </dbReference>
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        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="78"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="5">
        <location>
            <begin position="500"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5480901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="607" mass="66266" checksum="B84C572D4423881A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GTX8</accession>
    <name>A0A836GTX8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_00090</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058281.1">
        <property type="nucleotide sequence ID" value="XM_067202180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GTX8"/>
    <dbReference type="SMR" id="A0A836GTX8"/>
    <dbReference type="GeneID" id="92356114"/>
    <dbReference type="KEGG" id="loi:92356114"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
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        <property type="project" value="UniProtKB-KW"/>
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            <position position="50"/>
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            <dbReference type="ARBA" id="ARBA00022840"/>
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    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        </source>
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        <source>
            <dbReference type="EMBL" id="KAG5464650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="786" mass="87532" checksum="7946D66D66BADBB6" modified="2021-09-29" version="1"> </sequence>
</entry>
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            <fullName evidence="4">EF-hand domain-containing protein</fullName>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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            <end position="30"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5465265.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1364" mass="151189" checksum="74CD00E685531D0E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
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    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
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        <lineage>
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            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067205816.1"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="CALM/Myosin/TropC-like"/>
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        <location>
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        </location>
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    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="81"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5474647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GYA7</accession>
    <name>A0A836GYA7_9TRYP</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">LSCM4_05642</name>
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            <taxon>Kinetoplastea</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000016">
        <property type="protein sequence ID" value="KAG5482384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067207576.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="92361510"/>
    <dbReference type="KEGG" id="loi:92361510"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5482384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="508" mass="55426" checksum="928BB19B81251F01" modified="2021-09-29" version="1">MALSSQWSQAVVVRATADGEVIVPQQPNNGTARAMAAAGNPIIVRARTAANFGEGVALNAGGSGDRSSIGQGLFSSLITGYDVSQTFWVPNPSRGEMGLLEYLYRRGSANKSNVLLQSRPLPELQLNFSTCTGCNIDLSHNMFRLSKAAMALQHMDATLGDDGDYDDDSGVDVSVGGCGAGGSTEGNNFYTSGPSSSPSSRRSRMAPQRLSISTRAFKATMRASLQSLQEEDYYLVKYRDYSSWAVSEYRRICKTDSMFGRKYVEQCLAVHVGREPGELVLITEAQFMYGVDLLQRQLMNQLANAVPRLPAGWGGAGANHSSYQQYQIDINYSALNADQFRSLGALLGDGMRQVGVEGEEKKREEQAKAEARGRGRGSDDYYDYTPPSWYDWTPGAIRARVQHRLQGYYRSVGQLTVQLAVAGVCGFLVYRAAKGYVPGLSSHSDADYDGRGGRSGGSSHGGRRGDRYGGGRRIDDDYYYDYRPGLLRSILMGPKEVFDYMLAPAPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GZC1</accession>
    <name>A0A836GZC1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_01022</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059738.1">
        <property type="nucleotide sequence ID" value="XM_067203088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GZC1"/>
    <dbReference type="GeneID" id="92357022"/>
    <dbReference type="KEGG" id="loi:92357022"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051581">
        <property type="entry name" value="Ca-bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34524">
        <property type="entry name" value="CALCYPHOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34524:SF6">
        <property type="entry name" value="CALCYPHOSINE LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="50"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="303"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5467936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="422" mass="47699" checksum="8075BACDBC5C5685" modified="2021-09-29" version="1">MNRDPQNALQLEQTAEKTKRLLLQRSPSSVNGIRSFSRCLGIADDLGGTQVTAEELRRALQDNNVSLEEYEIQNIFTVLDRHGMGTIDPTDFIAVMCNSLRPLRKVWLQRVWRIFVKDPSDGSVHVHELQRRFIAEGHPSVVRGETTAEEIRKDFVSTFNESTNPDGRVSAHEFAEYYSGVSAGCSDDDSFVSLLRGVWPLPGVSHAFSVSLAKGEAHTQACYQTEQSLAEKTAIANREAARSEFMRMIRDEHAPVVLSSSAKARSLCLSLARADEACTGFVSELVFVDALRQHRLYVPSVSLLKCLDTNGDGSVDIKYYEALLLPSPSAVRLMLLARLWSRRFENKDTAFRTPVQELHRRYQASSPADKDAFLTAWDVRTAMHGKVDFEEIVQWYVPQSLAVQRDKDFEDLLHRQWGKYDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H035</accession>
    <name>A0A836H035_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein tyrosine phosphatase PRL-1</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LSCM4_05557</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="JAFHLR010000016">
        <property type="protein sequence ID" value="KAG5482304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064310.1">
        <property type="nucleotide sequence ID" value="XM_067207496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H035"/>
    <dbReference type="SMR" id="A0A836H035"/>
    <dbReference type="GeneID" id="92361430"/>
    <dbReference type="KEGG" id="loi:92361430"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14500">
        <property type="entry name" value="PTP-IVa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000086">
        <property type="entry name" value="Protein tyrosine phosphatase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057023">
        <property type="entry name" value="PTP-SAK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22784">
        <property type="entry name" value="PTP-SAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="11">
        <location>
            <begin position="13"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="12">
        <location>
            <begin position="85"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG5482304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="176" mass="19501" checksum="2391F49A2EEA6ABA" modified="2021-09-29" version="1">MDINGTVVDCKRNGAEEVIFRFLILDAPSPSSLPTYVKLLQRHSVRHLVRACGPTYNAELVEKNGIQVHGWTFDDGAPPTRAVIDSWLDLLSQEVGKTPPETVAVHCVAGLGRAPILVALALVEYGNMAPLDAVGYVRERRKGAINQVQLNWLMRYKPRHHQASDRSLVCTNCCIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H0D6</accession>
    <name>A0A836H0D6_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_01174</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5468085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059887.1">
        <property type="nucleotide sequence ID" value="XM_067203237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H0D6"/>
    <dbReference type="SMR" id="A0A836H0D6"/>
    <dbReference type="GeneID" id="92357171"/>
    <dbReference type="KEGG" id="loi:92357171"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47822">
        <property type="entry name" value="CARBOHYDRATE BINDING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47822:SF2">
        <property type="entry name" value="F-BOX AND WD-40 DOMAIN PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5468085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="325" mass="35115" checksum="EC8D1139A509B480" modified="2021-09-29" version="1">MSLNIAAHQLLEADQNVHFCSLSPDAKHVACALSSGVVCALSTITFTAVARGAPGKDFMDVPATCIRWAPAHCDSDWQLVSSSSAGGVMLWHWDHSEFSLRRGTVAYERNNEVMVVDVSPSGKRVLAAGSDRIVRLYNSQLTLLAQLTEGVNADGTSRSTHVNRIFSVRFLTEMSAVSAGWESPIQLWDLRSNRSTRQVVGLQGVSDCLEPVPDTQIVVMASPKSVDTLHLFDTVTARVLKENSQNVCSQLNPAERVVLCRFQPETGYAWCLTASPHSVVLIRLSSGLIVARAPLSSTPLSMTVNADQVVVGCKNGTVLHVSLSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H1C0</accession>
    <name>A0A836H1C0_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059993.1">
        <property type="nucleotide sequence ID" value="XM_067204441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H1C0"/>
    <dbReference type="GeneID" id="92358375"/>
    <dbReference type="KEGG" id="loi:92358375"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="451"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5469016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="586" mass="65458" checksum="4CBA5E3A41495503" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H1I5</accession>
    <name>A0A836H1I5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_02533</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060113.1">
        <property type="nucleotide sequence ID" value="XM_067204561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H1I5"/>
    <dbReference type="GeneID" id="92358495"/>
    <dbReference type="KEGG" id="loi:92358495"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="8"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="444"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="604"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="673"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="481"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="546"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="614"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5469136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1010" mass="110419" checksum="5112FE7832A64776" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H2K4</accession>
    <name>A0A836H2K4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_02608</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060187.1">
        <property type="nucleotide sequence ID" value="XM_067204635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H2K4"/>
    <dbReference type="SMR" id="A0A836H2K4"/>
    <dbReference type="GeneID" id="92358569"/>
    <dbReference type="KEGG" id="loi:92358569"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04165">
        <property type="entry name" value="GTPBP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03708">
        <property type="entry name" value="GTPBP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000084">
        <property type="entry name" value="GTP-binding elongation factor Tu family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000014">
        <property type="entry name" value="Probable GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035531">
        <property type="entry name" value="GTPBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF28">
        <property type="entry name" value="ELONGATION FACTOR TU FAMILY, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="5">
        <location>
            <begin position="355"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="301"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="307"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5469210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="840" mass="90141" checksum="0E622A78A5E00478" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H2W0</accession>
    <name>A0A836H2W0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sucrose-6-phosphate hydrolase</fullName>
            <ecNumber evidence="4">3.2.1.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_04720</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>Hydrolysis of terminal non-reducing beta-D-fructofuranoside residues in beta-D-fructofuranosides.</text>
            <dbReference type="EC" id="3.2.1.26"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.26" evidence="4"/>
    <dbReference type="EMBL" id="JAFHLR010000023">
        <property type="protein sequence ID" value="KAG5478487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063148.1">
        <property type="nucleotide sequence ID" value="XM_067206701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H2W0"/>
    <dbReference type="SMR" id="A0A836H2W0"/>
    <dbReference type="GeneID" id="92360635"/>
    <dbReference type="KEGG" id="loi:92360635"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004564">
        <property type="term" value="F:beta-fructofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18623">
        <property type="entry name" value="GH32_ScrB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051214">
        <property type="entry name" value="GH32_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006232">
        <property type="entry name" value="Suc6P_hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01322">
        <property type="entry name" value="scrB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43101">
        <property type="entry name" value="BETA-FRUCTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43101:SF1">
        <property type="entry name" value="BETA-FRUCTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
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    </dbReference>
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    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="73"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 C-terminal" evidence="6">
        <location>
            <begin position="390"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5478487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="539" mass="61835" checksum="22B0807E7787C47B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H2Y9</accession>
    <name>A0A836H2Y9_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_07614</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000012">
        <property type="protein sequence ID" value="KAG5484844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064956.1">
        <property type="nucleotide sequence ID" value="XM_067209496.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92363430"/>
    <dbReference type="KEGG" id="loi:92363430"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="553"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="866"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="979"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1203"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1281"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1350"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="397"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="866"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="980"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="990"/>
            <end position="1007"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5484844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1526" mass="159518" checksum="383F2F4ED5DA61C7" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H3W1</accession>
    <name>A0A836H3W1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4200 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_07865</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000013">
        <property type="protein sequence ID" value="KAG5484299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064792.1">
        <property type="nucleotide sequence ID" value="XM_067209742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H3W1"/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
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            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
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    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-ribose + ATP = D-ribose 5-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13697"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:47013"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.15" evidence="9"/>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062041.1">
        <property type="nucleotide sequence ID" value="XM_067206104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H5M9"/>
    <dbReference type="SMR" id="A0A836H5M9"/>
    <dbReference type="GeneID" id="92360038"/>
    <dbReference type="KEGG" id="loi:92360038"/>
    <dbReference type="UniPathway" id="UPA00916">
        <property type="reaction ID" value="UER00889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004747">
        <property type="term" value="F:ribokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019303">
        <property type="term" value="P:D-ribose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01174">
        <property type="entry name" value="ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000102">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01987">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011877">
        <property type="entry name" value="Ribokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584:SF166">
        <property type="entry name" value="RIBOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 9" id="KW-0630">Potassium</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="10">
        <location>
            <begin position="17"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="25"/>
            <end position="27"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="53"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="245"/>
            <end position="250"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="277"/>
            <end position="278"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5475533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="329" mass="35250" checksum="16CD39F47ED2FFA4" modified="2021-09-29" version="1">MHRVQNVQSHTGEYAPLILVVGSCFLDYVGYVDHMPQVGETMHSESFHKGFGGKGANQAVAAGRLGAKVAMVSMVGTDGDGSDYIKELEKNGVNTAHVLRTGKSSTGLAMILVDTASSNNEIVICPNATNYLTPELLRAQTRNYETMMHPGLKFLISQNEIPLATTLDTIKEAHIRGVYTVFNTAPAPKPDEVKQMKPFLRYVSLLCPNEVEAALITGVKVTDTASAFRAIEALQRLGVRDVVITLGAAGFALSENGAAPVHVAGRRVKAVDTTGAGDCFVGSMVYFMSRGHSLLEACKRANECAAISVTRKGTQLSYPYPSELPADVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H5V9</accession>
    <name>A0A836H5V9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LSCM4_04235</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the diacylglycerol acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062161.1">
        <property type="nucleotide sequence ID" value="XM_067206224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H5V9"/>
    <dbReference type="GeneID" id="92360158"/>
    <dbReference type="KEGG" id="loi:92360158"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07987">
        <property type="entry name" value="LPLAT_MGAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007130">
        <property type="entry name" value="DAGAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317:SF34">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03982">
        <property type="entry name" value="DAGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="86"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="151"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG5475653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="513" mass="56803" checksum="0A2215FB680A77CF" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H6I7</accession>
    <name>A0A836H6I7_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_06219</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000020">
        <property type="protein sequence ID" value="KAG5480452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063783.1">
        <property type="nucleotide sequence ID" value="XM_067208143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H6I7"/>
    <dbReference type="GeneID" id="92362077"/>
    <dbReference type="KEGG" id="loi:92362077"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5480452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="359" mass="39380" checksum="21B520D10321C42A" modified="2021-09-29" version="1">MFILLPSCGRYTFEQRSLDGEAILHGGKEETHPNCGRCGACQTAGEESKEAPKDLRCLVMLLAPSRALLQQAGDTAAALYWMRRIASRVPASGLSGSQLQALLEDEFPSFSPSEVGAVTLKEAVLRFPQLLSVEDCNHLQAKWHVRPAHVPEGQERSASSSPKSAEMYALPMMKLQQFCAKRARLHHNTYMPLEYVLGKVSIHDVNIVEAVLSNPDAALEVQAGVRIKPKRTPRAVVAFVDGDALPAVAVDEMCNELNVVKGSSIVTIVRQSCSHALSAVDIVCPSVIPTYLSIEKHAHELRLRRPNVRHDIVYMCAASQFNTYAGHVALLNDFPDADVYVCCPSMITLVKPKKVIPFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H7E3</accession>
    <name>A0A836H7E3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">4-coumarate--CoA ligase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_06472</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000019">
        <property type="protein sequence ID" value="KAG5480902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063903.1">
        <property type="nucleotide sequence ID" value="XM_067208391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H7E3"/>
    <dbReference type="GeneID" id="92362325"/>
    <dbReference type="KEGG" id="loi:92362325"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="4">
        <location>
            <begin position="124"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="5">
        <location>
            <begin position="544"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="458"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5480902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="662" mass="72224" checksum="4421962CDFF8C388" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H854</accession>
    <name>A0A836H854_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_07017</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="3"/>
    <dbReference type="EMBL" id="JAFHLR010000018">
        <property type="protein sequence ID" value="KAG5481307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063986.1">
        <property type="nucleotide sequence ID" value="XM_067208923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H854"/>
    <dbReference type="SMR" id="A0A836H854"/>
    <dbReference type="GeneID" id="92362857"/>
    <dbReference type="KEGG" id="loi:92362857"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07417">
        <property type="entry name" value="MPP_PP5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000930">
        <property type="entry name" value="Serine/threonine protein phosphatase type 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000125">
        <property type="entry name" value="Serine/threonine protein phosphatase type 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041753">
        <property type="entry name" value="PP5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013235">
        <property type="entry name" value="PPP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051134">
        <property type="entry name" value="PPP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668:SF5">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08321">
        <property type="entry name" value="PPP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033096">
        <property type="entry name" value="PPPtase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 10" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="71"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="11">
        <location>
            <begin position="176"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR033096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5481307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="469" mass="52954" checksum="457907DC777477AC" modified="2021-09-29" version="1">MEASDRLRQEGNAYFQEKKFQHAVDSYSQAIAAYKTPTLLCNRAFAYLKLELPGAALLDAQEAIDIEPGFVKAYYRKASAHLLLGKFKDAQKEFAAVLKLVPTEKDAQQKYDLCEKELRRLRFENAIKSKDGEPVSVTIKLGTIAASYSGPRIENDVITVEFVEAMQEHFRVEKKIDRRDVVFILLEVLKLFKSYPNFVTVMVPDGEDITVCGDTHGQFYDLLNIFKLNGKPSPTNRYLFNGDFVDRGSYSVENVLTLFAYKLLYPEHVFLSRGNHEGLSMNRVYGFEGEVRAKYSAEVFDLFSEVFNALPTGHILNEQVFVVHGGLYSRDDVTIADLQKPNRFREIPENGLICESLWADPQPMTGRSPSKRGVDCPSFGPDVTETFLKNNNLKLVVRSHEVKEEGYEVEHNGKCITVFSAPNYCDQMGNKGAFIRFTGGSMTPKYTTFTHVAHPGKRPMQYACGAGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HBH3</accession>
    <name>A0A836HBH3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_07308</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000015">
        <property type="protein sequence ID" value="KAG5483092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067209205.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="92363139"/>
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    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
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    </dbReference>
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        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 19"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 19"/>
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    </dbReference>
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        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="511"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5483092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="708" mass="77516" checksum="4A000DDA653B75B4" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HD05</accession>
    <name>A0A836HD05_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA-guanine(15) transglycosylase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_04078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062004.1">
        <property type="nucleotide sequence ID" value="XM_067206067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HD05"/>
    <dbReference type="SMR" id="A0A836HD05"/>
    <dbReference type="GeneID" id="92360001"/>
    <dbReference type="KEGG" id="loi:92360001"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="entry name" value="Queuine tRNA-ribosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050852">
        <property type="entry name" value="Queuine_tRNA-ribosyltrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46064">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE ACCESSORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46064:SF1">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE ACCESSORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="tRNA-guanine transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-guanine(15) transglycosylase-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5475496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="336" mass="36411" checksum="7A7C07ED2976399E" modified="2021-09-29" version="1">MDSQGPFLVIPTKRGAVLNLTPAQANAILEPPERILSTSVFEAMDFVKPCTEARLPLSDYCGLRGYKTVLTLRSSFHGLHASAPSTDSTVAGDSEKGRAVVSVERWREVVKAAQPALAVAIHDSVPLSEPLNKRRRVATTRSEAWLTRSGEAAELGCPLLPPILAAGPCNGGYIDVVPRGENSYEFFQTLQALKLSPTKCTMCIAPSIQALLAAMTSNVSLMECPLPWTLAEKGVALLLPVEDATTTLQQPLVPLLDLNDNVFALDIHPIAPGCDCFTCQRHCRAYVHHLLTVQEMNSDILLAMHNLAQVIRLVRAYRCADAPTREALVQRVASAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HE26</accession>
    <name>A0A836HE26_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062314.1">
        <property type="nucleotide sequence ID" value="XM_067207011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HE26"/>
    <dbReference type="GeneID" id="92360945"/>
    <dbReference type="KEGG" id="loi:92360945"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="500"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5476081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="704" mass="73708" checksum="5732CA4A1752639C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HF51</accession>
    <name>A0A836HF51_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S acidic ribosomal protein P0</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_04215</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 7">Ribosomal protein P0 is the functional equivalent of E.coli protein L10.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">P0 forms a pentameric complex by interaction with dimers of P1 and P2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062141.1">
        <property type="nucleotide sequence ID" value="XM_067206204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HF51"/>
    <dbReference type="SMR" id="A0A836HF51"/>
    <dbReference type="GeneID" id="92360138"/>
    <dbReference type="KEGG" id="loi:92360138"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05795">
        <property type="entry name" value="Ribosomal_P0_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.20:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1730:FF:000005">
        <property type="entry name" value="Ribosome assembly factor mrt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050323">
        <property type="entry name" value="Ribosomal_protein_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030670">
        <property type="entry name" value="uL10_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039087">
        <property type="entry name" value="L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="9">
        <location>
            <begin position="118"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="284"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR039087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5475633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="323" mass="34608" checksum="8A02DD7272F523C9" modified="2021-09-29" version="1">MPSITTAKREYEEHLVDCLTKYSCVLFVGMDNVRSQQVHDVRRALRGKAEFVMGKKTLQAKIVEKRAQAKDASPDAKLFNDQCEEHNLLSGNTGLIFTNNAVQDIKAVLDAHRVKAPARVGAIAPCDVVVPAGSTGMEPTQTSFFQALNIATKIAKGMVEIVTEKKVLSTGDKVDNSTATLLQKLNISPFYYQVDVLSVWDRGVLFTREDLNMTEDMVEKMLMEGLGNVAALSLGAGIPTSATIGPMLVDAFKNLLAVSVATSYEFEEHNGKFLREAAISGSLAGSGPAAAESAAAAPEASSAAAKEEPEESDEEDFGMGGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HFP0</accession>
    <name>A0A836HFP0_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_05962</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000011">
        <property type="protein sequence ID" value="KAG5485327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065064.1">
        <property type="nucleotide sequence ID" value="XM_067207890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HFP0"/>
    <dbReference type="SMR" id="A0A836HFP0"/>
    <dbReference type="GeneID" id="92361824"/>
    <dbReference type="KEGG" id="loi:92361824"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="604"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5485327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="960" mass="102646" checksum="3925B2E595E1EAC3" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HHM4</accession>
    <name>A0A836HHM4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sister chromatid cohesion protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_07871</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">LSCM4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SCC2/Nipped-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000013">
        <property type="protein sequence ID" value="KAG5484305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064798.1">
        <property type="nucleotide sequence ID" value="XM_067209748.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92363682"/>
    <dbReference type="KEGG" id="loi:92363682"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090694">
        <property type="term" value="C:Scc2-Scc4 cohesin loading complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061775">
        <property type="term" value="F:cohesin loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140588">
        <property type="term" value="P:chromatin looping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034087">
        <property type="term" value="P:establishment of mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071169">
        <property type="term" value="P:establishment of protein localization to chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024986">
        <property type="entry name" value="Nipped-B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033031">
        <property type="entry name" value="Scc2/Nipped-B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21704:SF18">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21704">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN DELANGIN SCC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12830">
        <property type="entry name" value="Nipped-B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Sister chromatid cohesion C-terminal" evidence="3">
        <location>
            <begin position="1554"/>
            <end position="1781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1455"/>
            <end position="1547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1942"/>
            <end position="2022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1490"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1987"/>
            <end position="2004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2005"/>
            <end position="2022"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU364107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5484305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="2022" mass="217641" checksum="ABF4000CF55C6C9E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HLU8</accession>
    <name>A0A836HLU8_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_07446</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000008">
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    <dbReference type="SMR" id="A0A836HLU8"/>
    <dbReference type="GeneID" id="92363267"/>
    <dbReference type="KEGG" id="loi:92363267"/>
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        <property type="component" value="Chromosome 8"/>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5486510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="101" mass="11663" checksum="DAE26DD0785AB96A" modified="2021-09-29" version="1">MSEQLAFHDVSNEAIQHMQASEALQKHLENAQLAHRVCVAKALKANEPPVEKCALTWGEVVMRYNQWSEYRPAFHDSDAQHKYSKYWTKKRLAADDSSAYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836HMW1_9TRYP</name>
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        <recommendedName>
            <fullName evidence="6">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="7" type="ORF">LSCM4_07859</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
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            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000013">
        <property type="protein sequence ID" value="KAG5484293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="GeneID" id="92363670"/>
    <dbReference type="KEGG" id="loi:92363670"/>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:lipid metabolic process"/>
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        <property type="entry name" value="AB_hydrolase_fold"/>
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        <property type="entry name" value="Fungal_lipase-type"/>
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        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR47413">
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF01764">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="128"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="604"/>
            <end position="625"/>
        </location>
    </feature>
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            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5484293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="798" mass="86667" checksum="E3EE697D30E28AC8" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HMW7</accession>
    <name>A0A836HMW7_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063436.1">
        <property type="nucleotide sequence ID" value="XM_067207663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HMW7"/>
    <dbReference type="SMR" id="A0A836HMW7"/>
    <dbReference type="GeneID" id="92361597"/>
    <dbReference type="KEGG" id="loi:92361597"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5479725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="529" mass="57899" checksum="12E729360E5AE0AD" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HQM6</accession>
    <name>A0A836HQM6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leucine-rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000019">
        <property type="protein sequence ID" value="KAG5480868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063869.1">
        <property type="nucleotide sequence ID" value="XM_067208357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HQM6"/>
    <dbReference type="GeneID" id="92362291"/>
    <dbReference type="KEGG" id="loi:92362291"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040091">
        <property type="entry name" value="LRRC56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22708">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22708:SF0">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="220"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5480868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="888" mass="93358" checksum="D21E0400F4582E86" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HUF8</accession>
    <name>A0A836HUF8_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_07512</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TTC21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000004">
        <property type="protein sequence ID" value="KAG5487833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066030.1">
        <property type="nucleotide sequence ID" value="XM_067209398.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836HUF8"/>
    <dbReference type="GeneID" id="92363332"/>
    <dbReference type="KEGG" id="loi:92363332"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030991">
        <property type="term" value="C:intraciliary transport particle A"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035721">
        <property type="term" value="P:intraciliary retrograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061512">
        <property type="term" value="P:protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:002011">
        <property type="entry name" value="Predicted tetratricopeptide repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056832">
        <property type="entry name" value="ARM_TT21_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056836">
        <property type="entry name" value="ARM_TT21_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056835">
        <property type="entry name" value="ARM_TT21_5th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056834">
        <property type="entry name" value="ARM_TT21_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056833">
        <property type="entry name" value="ARM_TT21_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040364">
        <property type="entry name" value="TTC21A/TTC21B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14699">
        <property type="entry name" value="STI2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14699:SF0">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 21 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25058">
        <property type="entry name" value="ARM_TT21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25060">
        <property type="entry name" value="ARM_TT21_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25068">
        <property type="entry name" value="ARM_TT21_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25064">
        <property type="entry name" value="ARM_TT21_5th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25063">
        <property type="entry name" value="ARM_TT21_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25062">
        <property type="entry name" value="ARM_TT21_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Tetratricopeptide repeat protein 21A/21B N-terminal ARM repeat" evidence="7">
        <location>
            <begin position="14"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Tetratricopeptide repeat protein 21A/21B second ARM" evidence="6">
        <location>
            <begin position="303"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="756"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="790"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="domain" description="Tetratricopeptide repeat protein 21A/21B fourth ARM" evidence="10">
        <location>
            <begin position="792"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="1069"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="domain" description="Tetratricopeptide repeat protein 21A/21B fifth ARM repeats" evidence="9">
        <location>
            <begin position="1070"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="domain" description="Tetratricopeptide repeat protein 21A/21B C-terminal ARM" evidence="8">
        <location>
            <begin position="1449"/>
            <end position="1569"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="1490"/>
            <end position="1523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1199"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1210"/>
            <end position="1226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5487833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1575" mass="172297" checksum="C058FFBE532AE646" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HV19</accession>
    <name>A0A836HV19_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphomevalonate kinase</fullName>
            <ecNumber evidence="3">2.7.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LSCM4_07320</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GHMP kinase family. Mevalonate kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.2" evidence="3"/>
    <dbReference type="EMBL" id="JAFHLR010000015">
        <property type="protein sequence ID" value="KAG5483103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064599.1">
        <property type="nucleotide sequence ID" value="XM_067209216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HV19"/>
    <dbReference type="GeneID" id="92363150"/>
    <dbReference type="KEGG" id="loi:92363150"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00099"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004631">
        <property type="term" value="F:phosphomevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016005">
        <property type="entry name" value="Erg8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035102">
        <property type="entry name" value="Phosphomevalonate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31814">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31814:SF2">
        <property type="entry name" value="PHOSPHOMEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017288">
        <property type="entry name" value="PMK_GHMP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="12">
        <location>
            <begin position="162"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG5483103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="462" mass="49425" checksum="DEF4599F17D4A15A" modified="2021-09-29" version="1">MSFTMEASAPGKVLILGGYLIVEPCTPANIGISIGVNARFTTRIVKAQPATAAASGQTVVHVNSPQFHQSFCFAANTSAGGTVSVKQTEGPRSPFIFYAILYSLAAAQSLGSNTDGEIWMELLADNDFYSQRNYLESQGKEVNVANLRSLTPHLPLVGAVSKTGLGSSAAMTTSIVACLCYHFNASRCSHEYVHRIAQIAHSVTQGKIGSGFDVYTATYGTCAYRRFPASRVSMMMEGAQQPTSVQVEALRQCVNMGEVWVPHESFRLPPGVRLVLGDVHQGGSSTPGMVAKVMAWHKSVADTPDNLWEQLRRNNEAYIAALRRMIDEAAAKPDDYAAAITVLQQVPSLPLFTADSEVARCIVEASRCAARSRALLREMGVAAEVKVEPMELKGLLDETAALPGVLAVGCPGAGGYDAIFALVLGDDCTVAVEAFWERYATMSVCPLLVREDPSGLLITPPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HWK7</accession>
    <name>A0A836HWK7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Leucine-rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_06562</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000010">
        <property type="protein sequence ID" value="KAG5485606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065190.1">
        <property type="nucleotide sequence ID" value="XM_067208479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HWK7"/>
    <dbReference type="SMR" id="A0A836HWK7"/>
    <dbReference type="GeneID" id="92362413"/>
    <dbReference type="KEGG" id="loi:92362413"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
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    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000008">
        <property type="protein sequence ID" value="KAG5486433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065499.1">
        <property type="nucleotide sequence ID" value="XM_067209256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836I1P4"/>
    <dbReference type="SMR" id="A0A836I1P4"/>
    <dbReference type="GeneID" id="92363190"/>
    <dbReference type="KEGG" id="loi:92363190"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Putative ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_uL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_uL2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="RIBOSOMAL PROTEIN L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL2 C-terminal" evidence="5">
        <location>
            <begin position="251"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="335"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="345"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5486433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="425" mass="47553" checksum="2E871BA0158A1A7F" modified="2021-09-29" version="1">MLRRQLHFSATGGVSTASAALLAGHGPSSAAAAVGASSSSTLFSVVASASPLVMPRRSVKLVNPIGKQGSQHYGLEPKLEAGRDTQLKHTEMYDGYTDDFGVFKEGPPVTLRLEYVRSPDHGYSQQILQKDIWSPFQVGANMMTYTPLYYDWKGFSSRDYFGHRSGTNPGSKVLLGHYRRDEERSWGYRIMVNHKPQKRIPKWLACVVHIPRKKTFLGFFLYANGAYVAELLTYKQLPRIIYNKGFQGCLPTLGQTVSLTEVTYGKEIHSVEMYPGHGGVICRASGTAAVVLRGSEPNLVPLLLPSKEVRLFDSTCHAVFGRRAGVMYNKQRNFSQRSVEENMPHRPKVHSKTKRVSSHPAGGGNGGSPNLLTPLDWRIHPRNCVKTKYWLSGYILRGRQYNRNQTVADIKSKTYSWANRDPVYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836I2S3</accession>
    <name>A0A836I2S3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LNS2/PITP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_07790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lipin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000006">
        <property type="protein sequence ID" value="KAG5487300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065797.1">
        <property type="nucleotide sequence ID" value="XM_067209667.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836I2S3"/>
    <dbReference type="GeneID" id="92363601"/>
    <dbReference type="KEGG" id="loi:92363601"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026058">
        <property type="entry name" value="LIPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007651">
        <property type="entry name" value="Lipin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013209">
        <property type="entry name" value="LNS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031315">
        <property type="entry name" value="LNS2/PITP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181">
        <property type="entry name" value="LIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181:SF12">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04571">
        <property type="entry name" value="Lipin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08235">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00775">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LNS2/PITP" evidence="3">
        <location>
            <begin position="674"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="191"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="299"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="392"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="534"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="905"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1212"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1340"/>
            <end position="1359"/>
        </location>
    </feature>
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        <location>
            <begin position="1374"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="400"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="416"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="534"/>
            <end position="546"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
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        <location>
            <begin position="905"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1249"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1310"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1340"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1389"/>
            <end position="1398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5487300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1405" mass="144102" checksum="2D91188F446EDE0D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836K7M2</accession>
    <name>A0A836K7M2_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_01317</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059064.1">
        <property type="nucleotide sequence ID" value="XM_067203373.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92357307"/>
    <dbReference type="KEGG" id="loi:92357307"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF66">
        <property type="entry name" value="OS04G0158400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="619"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="798"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="933"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2203"/>
            <end position="2271"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="521"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1835"/>
            <end position="1862"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2411"/>
            <end position="2487"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2587"/>
            <end position="2792"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2955"/>
            <end position="2989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="619"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="808"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="944"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2203"/>
            <end position="2214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2237"/>
            <end position="2250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5466174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="3035" mass="326168" checksum="3ADCA7A535B8F8BE" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836K9E3</accession>
    <name>A0A836K9E3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_00503</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058682.1">
        <property type="nucleotide sequence ID" value="XM_067202581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836K9E3"/>
    <dbReference type="SMR" id="A0A836K9E3"/>
    <dbReference type="GeneID" id="92356515"/>
    <dbReference type="KEGG" id="loi:92356515"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359:SF95">
        <property type="entry name" value="CYTOCHROME B5 TYPE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="5">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5465051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="79" mass="9000" checksum="BB68715579412DA2" modified="2021-09-29" version="1">MKEYTREDVAAHCTPQDFWVIVDGRVYHLDVDFVTTLHPGGLIIMESAGKDGSVTFHEHHNAEKVKSVLEEYCIGKLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KAB5</accession>
    <name>A0A836KAB5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Choline/ethanolamine kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_01319</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the choline/ethanolamine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059066.1">
        <property type="nucleotide sequence ID" value="XM_067203375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KAB5"/>
    <dbReference type="GeneID" id="92357309"/>
    <dbReference type="KEGG" id="loi:92357309"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004305">
        <property type="term" value="F:ethanolamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603">
        <property type="entry name" value="CHOLINE/ETHANOALAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603:SF96">
        <property type="entry name" value="KINASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5466176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="669" mass="76471" checksum="3E4B46B4C246CA27" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KAF8</accession>
    <name>A0A836KAF8_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059216.1">
        <property type="nucleotide sequence ID" value="XM_067203525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KAF8"/>
    <dbReference type="SMR" id="A0A836KAF8"/>
    <dbReference type="GeneID" id="92357459"/>
    <dbReference type="KEGG" id="loi:92357459"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5466326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="152" mass="17787" checksum="0A52B75DBFCEDFA3" modified="2021-09-29" version="1">MTKLVRKLKQLAKKRAHRKTVQKRKIERAQRELERNSEQRSQRLEDEVDREMARLNGELESEANARPGTSCRQTDETATNEAVKRALRIVGDLVVDAPVKQSMKQLTRKQAKRKKKMVERGLAVSDSLSKKWDRKKRCIKVRAQIRNENLQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KBG7</accession>
    <name>A0A836KBG7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycerophosphocholine acyltransferase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LSCM4_01259</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GPC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059007.1">
        <property type="nucleotide sequence ID" value="XM_067203316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KBG7"/>
    <dbReference type="GeneID" id="92357250"/>
    <dbReference type="KEGG" id="loi:92357250"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021261">
        <property type="entry name" value="GPCAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31201:SF1">
        <property type="entry name" value="GLYCEROPHOSPHOCHOLINE ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31201">
        <property type="entry name" value="OS01G0585100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10998">
        <property type="entry name" value="DUF2838"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="10"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="209"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="512"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="539"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="574"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG5466117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="598" mass="68269" checksum="404E717537AA0AD5" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KBJ5</accession>
    <name>A0A836KBJ5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Guanylate kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_00236</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the guanylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058426.1">
        <property type="nucleotide sequence ID" value="XM_067202325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KBJ5"/>
    <dbReference type="SMR" id="A0A836KBJ5"/>
    <dbReference type="GeneID" id="92356259"/>
    <dbReference type="KEGG" id="loi:92356259"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:GMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.63.10:FF:000002">
        <property type="entry name" value="Guanylate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117:SF13">
        <property type="entry name" value="GUANYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117">
        <property type="entry name" value="GUANYLATE KINASE-RELATED"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="5">
        <location>
            <begin position="42"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5464795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="315" mass="34945" checksum="F1B5C10C8E480FA0" modified="2021-09-29" version="1">MSAAPKASMPVISTVAVASAAHNAARRAMEPLKGTVSLKRLVDVLLFVGPSGCGKSTMIHRLQRDWPTLFEFSVSHTTRRPRRGEVPGQHYHFVTREEFQQLIDMGSMIEYSHLGFHEASSSSRQSRPVGDLYGTSKKAVSVVLEHNRVVLMDTDLRGAINMRRYCAGEVVGMRPVIASQRGRGVAQQDSGTASPAPVPLESKHAVAPTRATLSEGAALSPAPCPEPRATRTLRCMIIFIAPPSMEVLEQRLRGRKSETEASLQLRMQLNKQWMQWARENQSLFDYYIVNDDLELCYTKVKSIVQSEVLKVESSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KCX1</accession>
    <name>A0A836KCX1_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060123.1">
        <property type="nucleotide sequence ID" value="XM_067204571.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92358505"/>
    <dbReference type="KEGG" id="loi:92358505"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="600"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="853"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1184"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="527"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="853"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1184"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1209"/>
            <end position="1238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5469146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1413" mass="148652" checksum="971B953DC81EFE73" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KCY3</accession>
    <name>A0A836KCY3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase M20 dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_03307</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060871.1">
        <property type="nucleotide sequence ID" value="XM_067205319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KCY3"/>
    <dbReference type="SMR" id="A0A836KCY3"/>
    <dbReference type="GeneID" id="92359253"/>
    <dbReference type="KEGG" id="loi:92359253"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05682">
        <property type="entry name" value="M20_dipept_dapE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051458">
        <property type="entry name" value="Cyt/Met_Dipeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270">
        <property type="entry name" value="BETA-ALA-HIS DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270:SF4">
        <property type="entry name" value="CARNOSINE DIPEPTIDASE 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="4">
        <location>
            <begin position="207"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5471754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="471" mass="50903" checksum="DBBE9A91DDFD492A" modified="2021-09-29" version="1">MSADWARVRQAVESEWDSTIVSAISAYIEVPNQSPQFDPEWATNGLQEKAFGILIDWMKAQGVQGLTYEYLTAEGRTPFLLVEIAGTVPTKNTVLMYGHMDKQPPLRPWAEGLDPHKAVVLQDKLYGRGGADDGYALFGAITAVSSLQRNGISHGRIVVAIEAGEESGSPDLDYYMERCKERIGNVDLMVCLDSGSMNYTQLWLTTSLRGIAIGELTVQTLTESMHSGVAGGVVPDTFRIVRILLDRIENCKTGEVTIPEAHCEIPLSASKAAEAMMAVPFKEQFSMAPGVSTVPGDNVELSIQNFWKPSLTVTGANLPDPQNAGNVIRTHTTVKLSMRLPPLVKAEAALQAMKRILEADPPYGAKVTFKCVSAGNGCAAPELKPWLHNALHEGSIDAFGNTYACQGMGGAIPFIGMLIDMYPSAQFVVTGLLGPQSNAHGPNEFLHIPYAKGLTFSIARIVAAHFDNTPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KD15</accession>
    <name>A0A836KD15_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">lactoylglutathione lyase</fullName>
            <ecNumber evidence="3">4.4.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Glyoxalase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_01488</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(R)-S-lactoylglutathione = methylglyoxal + glutathione</text>
            <dbReference type="Rhea" id="RHEA:19069"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="ChEBI" id="CHEBI:57474"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="EC" id="4.4.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glyoxalase I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.5" evidence="3"/>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059230.1">
        <property type="nucleotide sequence ID" value="XM_067203539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KD15"/>
    <dbReference type="SMR" id="A0A836KD15"/>
    <dbReference type="GeneID" id="92357473"/>
    <dbReference type="KEGG" id="loi:92357473"/>
    <dbReference type="UniPathway" id="UPA00619">
        <property type="reaction ID" value="UER00675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004462">
        <property type="term" value="F:lactoylglutathione lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004361">
        <property type="entry name" value="Glyoxalase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018146">
        <property type="entry name" value="Glyoxalase_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00068">
        <property type="entry name" value="glyox_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46036">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46036:SF5">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00934">
        <property type="entry name" value="GLYOXALASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="VOC" evidence="10">
        <location>
            <begin position="5"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR604361-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR604361-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5466340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="141" mass="16188" checksum="67B0D8836CBB367D" modified="2021-09-29" version="1">MPSRRMLHTMIRVGDLDRSVKFYTERLGMTLLRKWDVPEEEYTLVFLGYGTEMNSTVLELTYNYGVTSYKHGEGYGHVAIGVEDVKALVAEMRQHDVPVDYEDESGFMAFVVDPDGYKIELLNEKMMMIKAESDMKEQGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KDX1</accession>
    <name>A0A836KDX1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Centrosomal protein CEP104 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_02314</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5468922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059899.1">
        <property type="nucleotide sequence ID" value="XM_067204347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KDX1"/>
    <dbReference type="SMR" id="A0A836KDX1"/>
    <dbReference type="GeneID" id="92358281"/>
    <dbReference type="KEGG" id="loi:92358281"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052607">
        <property type="entry name" value="CEP104-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048739">
        <property type="entry name" value="CEP104_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13371">
        <property type="entry name" value="GLYCINE-, GLUTAMATE-, THIENYLCYCLOHEXYLPIPERIDINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13371:SF3">
        <property type="entry name" value="TOG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21040">
        <property type="entry name" value="CEP104-like_TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21038">
        <property type="entry name" value="CEP104_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centrosomal protein CEP104 N-terminal" evidence="2">
        <location>
            <begin position="40"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5468922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="695" mass="76349" checksum="F6293A199F602D0E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KGE8</accession>
    <name>A0A836KGE8_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_03356</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060919.1">
        <property type="nucleotide sequence ID" value="XM_067205367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KGE8"/>
    <dbReference type="GeneID" id="92359301"/>
    <dbReference type="KEGG" id="loi:92359301"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5471802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="223" mass="24922" checksum="FE201764AB7CDB58" modified="2021-09-29" version="1">MSETQSPSVASGTQIVVQKRGTYERGKWSTRVLTIDPNTCTVTISRKNKPEDVLHRSLCVEKVEMWPRFSCNLIENDFRSLKAKMVLCLTGTEVTLTDRAAVKKLMRSSIQSLVAASVAAEDSITGTSTTKRLTLRDIFSKNNPVFNTSTSTSNDNSTTSWVIRFPSIDSYELAVMLFMRCKNQDGSRRKVFSSNATEDLTVVKNAWESQLEEKNAVHITTVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KGQ3</accession>
    <name>A0A836KGQ3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_02829</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060401.1">
        <property type="nucleotide sequence ID" value="XM_067204849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KGQ3"/>
    <dbReference type="SMR" id="A0A836KGQ3"/>
    <dbReference type="GeneID" id="92358783"/>
    <dbReference type="KEGG" id="loi:92358783"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="116"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5470135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="317" mass="35220" checksum="705541D877B664F0" modified="2021-09-29" version="1">MELSPSPTLSEDLAGNGSSSSGFQPRRSSAHKSRPSYPPSNTPPHHMRGRTATATFSAEHRMDAAIANDYRESEGRKDHNIARSGHIKWRKLANEQAQLSTKEAKMVVVRGNDGFAYRRSVQVFFVNENAQFLLCQPVGKCNVNFRQTVQGGSEGEESPQETARREAWEEIGLVVATDATFVCEVRPLDAASGEEEEVRNEKGEILSELRRSFRYSSKTWRKLGIRGQELYPLLYLLEQKRIRHVDTCGWRRGVPSEFHSVEWGSLADLADKAPPTKKAVMESVCRAVAAAAKPFLESRGYPSTGLTNLISDEPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KGS5</accession>
    <name>A0A836KGS5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zinc finger C2H2 LYAR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_03595</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061529.1">
        <property type="nucleotide sequence ID" value="XM_067205592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KGS5"/>
    <dbReference type="SMR" id="A0A836KGS5"/>
    <dbReference type="GeneID" id="92359526"/>
    <dbReference type="KEGG" id="loi:92359526"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.490:FF:000001">
        <property type="entry name" value="cell growth-regulating nucleolar protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039999">
        <property type="entry name" value="LYAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014898">
        <property type="entry name" value="Znf_C2H2_LYAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13100:SF10">
        <property type="entry name" value="CELL GROWTH-REGULATING NUCLEOLAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13100">
        <property type="entry name" value="CELL GROWTH-REGULATING NUCLEOLAR PROTEIN LYAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08790">
        <property type="entry name" value="zf-LYAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51804">
        <property type="entry name" value="ZF_C2HC_LYAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger C2H2 LYAR-type" evidence="9">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="53"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="126"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5473526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="325" mass="34461" checksum="19F689BC0E468DB3" modified="2021-09-29" version="1">MVSFTCNCCQDVVKKPKVQSHANACGGETFTCVDCMHVFDLDTVKGHTSCVTEEEKYQGKWKQKLRDGSRSARAVEAPRGGMERPPRAPMNDLSSSDDSSDDWATRRSSKRAGVSEKPAAATSNGHQKRSATTSRKHPRPGVSLTSSEDDDDVREIAAAVPMAAPAHKKAKKVCSAPATPSSTRPVAAPVSAERSPAKEKPAAKKSAAALVSPVPHRSSKEMNREGEGEVAHTGKKDTPLLLPRSTMSTDCIVPSFVLGTSKEVADIVADVLSDSGVSSMPTKELAKELVVRYAKRIAKSVRHAVETAAELGALTIDSEGSVSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KGW4</accession>
    <name>A0A836KGW4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_02995</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060566.1">
        <property type="nucleotide sequence ID" value="XM_067205014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KGW4"/>
    <dbReference type="SMR" id="A0A836KGW4"/>
    <dbReference type="GeneID" id="92358948"/>
    <dbReference type="KEGG" id="loi:92358948"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01876">
        <property type="entry name" value="YihA_EngB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030393">
        <property type="entry name" value="G_ENGB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11649:SF76">
        <property type="entry name" value="ENGB-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11649">
        <property type="entry name" value="MSS1/TRME-RELATED GTP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032657218" description="G domain-containing protein" evidence="6">
        <location>
            <begin position="23"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="domain" description="G" evidence="7">
        <location>
            <begin position="86"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="424"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="424"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5470300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="756" mass="82640" checksum="DDFA9BF1CBF20710" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KHL1</accession>
    <name>A0A836KHL1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_05265</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-alanine--D-alanine ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062517.1">
        <property type="nucleotide sequence ID" value="XM_067207214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KHL1"/>
    <dbReference type="SMR" id="A0A836KHL1"/>
    <dbReference type="GeneID" id="92361148"/>
    <dbReference type="KEGG" id="loi:92361148"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008716">
        <property type="term" value="F:D-alanine-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011095">
        <property type="entry name" value="Dala_Dala_lig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23132">
        <property type="entry name" value="D-ALANINE--D-ALANINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23132:SF23">
        <property type="entry name" value="D-ALANINE--D-ALANINE LIGASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07478">
        <property type="entry name" value="Dala_Dala_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-grasp" evidence="9">
        <location>
            <begin position="119"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="7">
        <location>
            <begin position="344"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="8">
        <location>
            <begin position="469"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5476284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="516" mass="59081" checksum="ABA605BAB0E0B574" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KIP6</accession>
    <name>A0A836KIP6_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_04285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062209.1">
        <property type="nucleotide sequence ID" value="XM_067206272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KIP6"/>
    <dbReference type="SMR" id="A0A836KIP6"/>
    <dbReference type="GeneID" id="92360206"/>
    <dbReference type="KEGG" id="loi:92360206"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01049">
        <property type="entry name" value="RNRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="entry name" value="Ribonucleotide Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033909">
        <property type="entry name" value="RNR_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030475">
        <property type="entry name" value="RNR_small_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409:SF18">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00368">
        <property type="entry name" value="RIBORED_SMALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5475701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="388" mass="43957" checksum="F2006E53CDB1D403" modified="2021-09-29" version="1">MSSTEASLQPAAKRAREENTETEVAHMATAGAAADAAKVDDLVVKPIAAGAEVSAVDEATEGTSAEEEPLQRENPFRYVLFPIQYHDIWRKYKEQESCIWTVEEIDLGNDMKDWVALDDGERHFIKHVLAFFAGSDGIVVENLAQRFMNDVKVPEARAFYGFQLMMENIHSETYSVLLDTYITDSEEKLRLLHAIQTIPCIKKKAEWAVRWIGSSASFQERLIGFAAVEGIFFSGSFCALFWLKKRGLMPGLTFSNELISRDEGLHTDFACLLYNSHIRHKLPRERVLEIIVDAVNIEREFICDALPVRLIGMNSELMAQYIEFVADRLLVSLGEEKHYNATQPFDFMEMISLQGKTNFFEKKVGEYQKAGVMSTEGTSKKFSLSEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KJ55</accession>
    <name>A0A836KJ55_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_03979</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061908.1">
        <property type="nucleotide sequence ID" value="XM_067205971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KJ55"/>
    <dbReference type="SMR" id="A0A836KJ55"/>
    <dbReference type="GeneID" id="92359905"/>
    <dbReference type="KEGG" id="loi:92359905"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5474802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="328" mass="36405" checksum="8E1B0B3F19A57227" modified="2021-09-29" version="1">MRGSKAHLFLLRCSERRKVRSMPLTLALGSVCGSCVLPLSAAHGALSTCKRWQSAISFSEDAAQSATLSASLKAGDARSDNDVPVMERAADARREIYELWSRTAAAEEHAQASPTFTSTDEAAAAEVKAAEERWEAVAALLEKYKLDPATPREDDISRGLGDALDRLLLLCVPLSPKHGTDLLVKLMHVSARQGRQLSMRTIQHLFARTNSYAEALAIFYAMRRSNFAMSMEAYHAMLYSLQRLEEEGWAARFHEEFAASNGEAVSEQALDFILRGVDNQLMPENKPWLGRIMFAEVKDNQATKRQSIASFDEMGQLWVQRYKSGATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KK78</accession>
    <name>A0A836KK78_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_04555</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">LSCM4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062747.1">
        <property type="nucleotide sequence ID" value="XM_067206538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KK78"/>
    <dbReference type="SMR" id="A0A836KK78"/>
    <dbReference type="GeneID" id="92360472"/>
    <dbReference type="KEGG" id="loi:92360472"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00106">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000083">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF36">
        <property type="entry name" value="KINESIN HEAVY CHAIN ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="84"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="965"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="468"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="567"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="249"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="965"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="179"/>
            <end position="186"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5477336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1061" mass="117226" checksum="66CE5A7E8C9C598B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KKR6</accession>
    <name>A0A836KKR6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flagellar attachment zone protein 1 conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_01876</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000022">
        <property type="protein sequence ID" value="KAG5479284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063377.1">
        <property type="nucleotide sequence ID" value="XM_067203918.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92357852"/>
    <dbReference type="KEGG" id="loi:92357852"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056614">
        <property type="entry name" value="FAZ1_cons"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36685">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36685:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23398">
        <property type="entry name" value="FAZ1_cons"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flagellar attachment zone protein 1 conserved" evidence="3">
        <location>
            <begin position="4552"/>
            <end position="4635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="137"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1070"/>
            <end position="1629"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1663"/>
            <end position="1851"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1880"/>
            <end position="2103"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2132"/>
            <end position="4473"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="4500"/>
            <end position="4534"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="4715"/>
            <end position="4745"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="4965"/>
            <end position="4999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5479284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="5061" mass="506620" checksum="7B8D3DB9D86D5871" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KME1</accession>
    <name>A0A836KME1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_06397</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000019">
        <property type="protein sequence ID" value="KAG5480829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063830.1">
        <property type="nucleotide sequence ID" value="XM_067208318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KME1"/>
    <dbReference type="SMR" id="A0A836KME1"/>
    <dbReference type="GeneID" id="92362252"/>
    <dbReference type="KEGG" id="loi:92362252"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06606">
        <property type="entry name" value="STKc_MAPKKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000888">
        <property type="entry name" value="Mitogen-activated protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF56">
        <property type="entry name" value="MAPKK KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="12"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5480829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="280" mass="30802" checksum="01FED3C223B0F4B8" modified="2021-09-29" version="1">MAAISTKELMDVTLGKKLGSGSFGSVFVGVLPSGNFVAVKILELSDDAPSNTEVEIHQKMVHPNIIRYLYSRIDAESTPKKLYVYLEFVTGGSVTSLMKSLPNGCLPYSVVRVYARHMFQGLEYLHSNQVAHRDIKGDNVLISMDTGTAKLADFDQAKIMNTHGTLRKAATATLAGTPYWMAPEVITDEDGYDPFKADIWSAGCTVAEMITGRAPWTPMPNVMHIMNKLALSTGWPDAVPKDAQKLGSQDAYDFLDLCFQRDVSKRPPAATLLKHVFLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KMQ5</accession>
    <name>A0A836KMQ5_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_05220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062473.1">
        <property type="nucleotide sequence ID" value="XM_067207170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KMQ5"/>
    <dbReference type="SMR" id="A0A836KMQ5"/>
    <dbReference type="GeneID" id="92361104"/>
    <dbReference type="KEGG" id="loi:92361104"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5476240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="113" mass="13314" checksum="9E52EF7062D84F3D" modified="2021-09-29" version="1">MSRNTKEFNQKADRFAEEYKEQRVALERCLQSRINDDINFVCQRQKSAYLEGIAKLFCKKEYDTGVMCQRAAGDRWATDCFKENVAFGQCTDRVLKQLYVYNLEHSQKNPRAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KMZ2</accession>
    <name>A0A836KMZ2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Acetyl-CoA C-acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_03265</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">LSCM4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060830.1">
        <property type="nucleotide sequence ID" value="XM_067205278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KMZ2"/>
    <dbReference type="SMR" id="A0A836KMZ2"/>
    <dbReference type="GeneID" id="92359212"/>
    <dbReference type="KEGG" id="loi:92359212"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050521">
        <property type="entry name" value="3-ketoacyl-CoA_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42689">
        <property type="entry name" value="ACETYL-COA ACYLTRANSFERASE FADA2 (3-KETOACYL-COA THIOLASE) (BETA-KETOTHIOLASE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42689:SF1">
        <property type="entry name" value="ACETYL-COA ACYLTRANSFERASE FADA2 (3-KETOACYL-COA THIOLASE) (BETA-KETOTHIOLASE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="6">
        <location>
            <begin position="13"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="7">
        <location>
            <begin position="298"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="4">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="392"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5471713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="439" mass="46699" checksum="D08F1B61060A861B" modified="2021-09-29" version="1">MHSSRHILRQRAVFVTGVRTPFVKSFGALMKADTVQLASAAVAGLLNKTSLDPTVVDHIVWGNVVLQGSAHNCAREIVIDLNLPKKITANLTSMACASGLSALSQACMLIEGGHADVVIAGGSDSVSNAELPLPRSVTHGLMMAQRKGIMGFFKEAGYNPSRWLPSGVALTERSTGKTMGWHGDVIGELNSISREDQEALAVASHANAARAEKAGYFSDEIVPVMVDATKNIEVKCDDVLQRDTEKMKAKMPSLKPVFRKDKGTITAATSSALTDGGSAMLVMSEEKAKKLGYPTDVSVKSWYFCGIDPYPQLLLAPVLGWGPALRKAGLAPKDIDLYEIHEAFAAQVLATIKCLRSQEFFDRYAGGGKPLLTEDIDRSRLNVNGGSLALGHPFAATGGRIVTSLANELRRSGKRHGLVSICAAGGLGGVAVLEHTPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KN31</accession>
    <name>A0A836KN31_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Smr domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_03391</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060950.1">
        <property type="nucleotide sequence ID" value="XM_067205398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KN31"/>
    <dbReference type="SMR" id="A0A836KN31"/>
    <dbReference type="GeneID" id="92359332"/>
    <dbReference type="KEGG" id="loi:92359332"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00105">
        <property type="entry name" value="KH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013899">
        <property type="entry name" value="DUF1771"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053020">
        <property type="entry name" value="Smr_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47417">
        <property type="entry name" value="SMR DOMAIN-CONTAINING PROTEIN YPL199C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47417:SF1">
        <property type="entry name" value="SMR DOMAIN-CONTAINING PROTEIN YPL199C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08590">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01162">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Smr" evidence="3">
        <location>
            <begin position="151"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="235"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5471833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="268" mass="28870" checksum="31BAC43B8A0F92BD" modified="2021-09-29" version="1">MPEICISITKVQVGHIVGKGACTLRAIQNRTGAKLEILDEGPQVKITADDAAQVAAARAEVQKIVAQQENPDYEGPEGARLRKEANNLGHKRSTLFDEATKRREVGDHEGANKLVVLAKQAGEDMQACHRKAAAAIARHNNEDKGKGEDFFDMHGLRLEEAMEMLKARMTRLEEKPEGTMTEFELIPGAGHHSAPGAQKLKGATLEYVASKGYAYEEVNAGTFLVKVPGLGEGVLSKPEDGDKAPAKPKQSDKAAARKSVSKSCCVCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KP17</accession>
    <name>A0A836KP17_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_02208</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061279.1">
        <property type="nucleotide sequence ID" value="XM_067204242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KP17"/>
    <dbReference type="GeneID" id="92358176"/>
    <dbReference type="KEGG" id="loi:92358176"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5472883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="385" mass="41047" checksum="B27ED378FE83E337" modified="2021-09-29" version="1">MSAVRTAFPLLTRGRRGGGRGVSVADLTTRMTSVSQTILLPLRSQLQDVLHQPLPITEEGILCALQVGADLTVPLTIIGSCDDGNSEAGVKGKLVVHTTGLPGGFVVSGEELVRGRARLRPPFRLAKGGTPSSLGSVCLMEAVTKELLTESNNAPTPSASPRGVLDVFYRLARRRHFSLVGMCRVLDCGSRLHPGALQLDFPYQCGGAQATKRYLDITDEVTNVFGAHMRHGTKVLSRYGVAVSVGVVDRITSMTAPTLMWHPSGAPAACLAPMLLGCPVLPLGTMALDYNGPVPGSPLTIKEDPRRYMNFIGNNRYDNSVWLTQGLFGVKPGDSWSPPGKAGGGVDAALTPYEVVGVRYDEVTEEMELLVRDTVTNEVVEAADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KQ45</accession>
    <name>A0A836KQ45_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ethanolamine phosphotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_07083</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000018">
        <property type="protein sequence ID" value="KAG5481372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064051.1">
        <property type="nucleotide sequence ID" value="XM_067208988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KQ45"/>
    <dbReference type="GeneID" id="92362922"/>
    <dbReference type="KEGG" id="loi:92362922"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014472">
        <property type="entry name" value="CHOPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414:SF68">
        <property type="entry name" value="ETHANOLAMINE PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414">
        <property type="entry name" value="ETHANOLAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5481372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="410" mass="44595" checksum="6F699631118B85E7" modified="2021-09-29" version="1">MQSWISSAAPPGTPSVSAEPSIMAEHLFFPFYDYIVQFYPESWVPNKVTLVGIFSTVFSSLLLLSSMPAGLQFHPGGIQLLPASLVEDPSTSQMPPLAPTVMTPVLPCVSPSLMLIVCGALNLLYCVADNTDGRLARRDKKTSVIGEYLDHGLDCVTSLLSVSCAFALLSSLCNMATSVCLIAFATALSHTLHFEANIFIWGNRIATVDEAMIFFGLGMWWPLVCPTVSTTRVPGWIIESIFGSDSSWTAYLRPLRMVELVYVFYSVALAQTIFSLVRRRWRMLFRIHVIFSVLNSILLLALIGVHSEHIAAATPATSVPGYTLGPFTYPAVWIITAACTSSTIIHIPIAARCARMPATNPLPLAGVMLVWFVFASCPVGGAILAVLLHVGQLLLNVELIKQCVRDNNAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KSG2</accession>
    <name>A0A836KSG2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleolar protein 16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_06632</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000010">
        <property type="protein sequence ID" value="KAG5485674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065258.1">
        <property type="nucleotide sequence ID" value="XM_067208547.1"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HSPC111 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13243:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09420">
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    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008479"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00015522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5485674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="196" mass="22695" checksum="2FC8EB17FCB35230" modified="2021-09-29" version="1">MGRVKVTPKGKVKKNIPITRVGKKQYLKRRFAHVRAVDVAGANNRFTQKYFEGNNTAEQTFTRLGLAIDPSAPKSVTEKRKAKVRPQTRRVFEEQNELAEHEKRVKATKIGRPVSEQEGSTIANLIQRYGTDLKRMTLDRKLNPFQLNMRQLQRQIVNYLKWEKAAFPKEFAEAEEKGWFSVEQFADPHLRSGQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KSI0</accession>
    <name>A0A836KSI0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Myotubularin-related 12-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_05949</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000011">
        <property type="protein sequence ID" value="KAG5485316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065053.1">
        <property type="nucleotide sequence ID" value="XM_067207879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KSI0"/>
    <dbReference type="SMR" id="A0A836KSI0"/>
    <dbReference type="GeneID" id="92361813"/>
    <dbReference type="KEGG" id="loi:92361813"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022587">
        <property type="entry name" value="MTMR12-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12578">
        <property type="entry name" value="3-PAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myotubularin-related 12-like C-terminal" evidence="3">
        <location>
            <begin position="10"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="243"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="310"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="418"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="525"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="112"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="243"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="312"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="431"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="450"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="492"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="602"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="647"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5485316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="709" mass="76186" checksum="8C6D231B47AB6133" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KT66</accession>
    <name>A0A836KT66_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_06927</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000017">
        <property type="protein sequence ID" value="KAG5481850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064210.1">
        <property type="nucleotide sequence ID" value="XM_067208836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KT66"/>
    <dbReference type="GeneID" id="92362770"/>
    <dbReference type="KEGG" id="loi:92362770"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
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        <property type="entry name" value="PINX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149:SF9">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5481850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="202" mass="21932" checksum="B1FFE4DFB6161BFD" modified="2021-09-29" version="1">MSAVAKKMMEKYGWKEGEGLGKERSGVKSYVKVTRRDPHTATGLGHAADPAQGGSLASTHAIELDAIYGQLRKETSKRHQRSSTARVHGADEGEEGNEGELSDMSTTTTTSSAVRTPECKKLPTAARAGVKRQRRVAPSSPSDSDSDGDDRTDSKRSKSDHVSDVTRMSDKELFQRCGGVCLGRAGRHRFFDGKLKRIHDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KT73</accession>
    <name>A0A836KT73_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial</fullName>
            <ecNumber evidence="6">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Succinyl-CoA synthetase subunit alpha</fullName>
            <shortName evidence="6">SCS-alpha</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_04572</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">LSCM4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>succinate + ATP + CoA = succinyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with the ATP-specific beta subunit SUCLA2, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with the GTP-specific beta subunit SUCLG2 forms a GDP-forming succinyl-CoA synthetase (G-SCS).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 8">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="6"/>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062764.1">
        <property type="nucleotide sequence ID" value="XM_067206555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KT73"/>
    <dbReference type="SMR" id="A0A836KT73"/>
    <dbReference type="GeneID" id="92360489"/>
    <dbReference type="KEGG" id="loi:92360489"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009361">
        <property type="term" value="C:succinate-CoA ligase complex (ADP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004776">
        <property type="term" value="F:succinate-CoA ligase (GDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000002">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000005">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01988">
        <property type="entry name" value="Succ_CoA_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005810">
        <property type="entry name" value="CoA_lig_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004230">
        <property type="entry name" value="PRK05678.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01019">
        <property type="entry name" value="sucCoAalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117:SF2">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP_GDP-FORMING] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117">
        <property type="entry name" value="SUCCINYL-COA LIGASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001553">
        <property type="entry name" value="SucCS_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01798">
        <property type="entry name" value="SCOASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="CoA-binding" evidence="9">
        <location>
            <begin position="10"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="6 7">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="23"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="102"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit beta</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001553-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5477353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="299" mass="30717" checksum="5131B0749AC7F999" modified="2021-09-29" version="1">MFARSAIRRWINKDTKVIVQGMTGKAGTFHTKAAIAYGTKVVGGVSPKKAGTTALGVPVFATAAEAAKATGATASVLYVPAPACAASIEEALDAELPLVVVITEGIPQWDMLRVKSMLLSQNKTRLIGPNCPGIIKPAECKIGIMPGHIHQKGKIGIVSRSGTLTYEAVSQTTAVGLGQSLCVGIGGDPFNGTNMVDCLKLFLNDPETEGIILIGEIGGTAEEEAADFIKNSPIKKPIVSFIGGATAPPGRRMGHAGAIVSGGMGTAKGKKEALRAAGVTISDSPADMGKHMAQLFAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KTB2</accession>
    <name>A0A836KTB2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Serine racemase</fullName>
            <ecNumber evidence="9">5.1.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">D-serine ammonia-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">D-serine dehydratase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">L-serine ammonia-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">L-serine dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LSCM4_07432</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">LSCM4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the synthesis of D-serine from L-serine. D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>D-serine = pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13977"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35247"/>
            <dbReference type="EC" id="4.3.1.18"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-serine = D-serine</text>
            <dbReference type="Rhea" id="RHEA:10980"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:35247"/>
            <dbReference type="EC" id="5.1.1.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.18" evidence="9"/>
    <dbReference type="EMBL" id="JAFHLR010000008">
        <property type="protein sequence ID" value="KAG5486499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065565.1">
        <property type="nucleotide sequence ID" value="XM_067209322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KTB2"/>
    <dbReference type="SMR" id="A0A836KTB2"/>
    <dbReference type="GeneID" id="92363256"/>
    <dbReference type="KEGG" id="loi:92363256"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008721">
        <property type="term" value="F:D-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030378">
        <property type="term" value="F:serine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:threonine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01562">
        <property type="entry name" value="Thr-dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000007">
        <property type="entry name" value="L-threonine dehydratase catabolic TdcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000041">
        <property type="entry name" value="Threonine ammonia-lyase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF19">
        <property type="entry name" value="ACT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="14">
        <location>
            <begin position="76"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00056426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00066592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00076108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00081060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00081761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG5486499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="461" mass="48811" checksum="882277F69B27AC46" modified="2021-09-29" version="1">MKATPCAPPAVSPENKTVAGQLAASVASSEAAIQALEKPRPKRAASDPWLSIELARRRISRYLHPTILIQGRPIPGTEVTTYYKCDHMHRSGSFKERGGLNALLCLSGEKRSKGVIAASAGNHAQALAYHGGMLGIPVTVVMPVSSPIVKRENCKNFGARVILHGKDFGSAKEEAMRLAKEKGYTYVNGFDDPEVIAGAGTCGLEILDQLPSVNVIVVPAGGGGLLAGIALAVKKMNPDVTVIGVESERCANVSRALKAGRPLYTPISAGGTVADGLAVDVVGTNTFAIIQRYVDSVITVPESYITRAILHMLEVEKMMVEGAGATALAAIMTGKLDAELKGKNVVTLITGGNIDITLIGRVINQGLYASGRLHMFDVAISNRVGGLANFMHALAKTGASVKSVSQETPLVNDINVTTLHMEVETMNDEHWASVVAMMRESGFVLLPFSGQKYNDVDMSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KWC2</accession>
    <name>A0A836KWC2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_08129</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000002">
        <property type="protein sequence ID" value="KAG5488152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066200.1">
        <property type="nucleotide sequence ID" value="XM_067210002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KWC2"/>
    <dbReference type="SMR" id="A0A836KWC2"/>
    <dbReference type="GeneID" id="92363936"/>
    <dbReference type="KEGG" id="loi:92363936"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000002">
        <property type="entry name" value="Cytochrome b5 type B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000007">
        <property type="entry name" value="Sulfite oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359:SF14">
        <property type="entry name" value="CYTOCHROME B5 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 8" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="9">
        <location>
            <begin position="2"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="9">
        <location>
            <begin position="83"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5488152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="218" mass="24173" checksum="18D81AE55B28A828" modified="2021-09-29" version="1">MPTIYSKSQVAEHNRKENGWLIINNAVYDVSKFYDDHPGGRDILLAHIGTDATEGFEAVHHSKGAMRKLKDLKVGELPENERRHYISMEQVAAKRSADSAWFVINNKVYDVTRFLDLHPGGRDVLLYNAGGDATQAFTDNGHSDMAYKMMGKYAIGGLEPSERNTFVSRMATGEQHTASPHAIFAKSENESLLGHIQEQLKLLAVLALFAIAGVFLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KX16</accession>
    <name>A0A836KX16_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_06756</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="JAFHLR010000009">
        <property type="protein sequence ID" value="KAG5486050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065381.1">
        <property type="nucleotide sequence ID" value="XM_067208670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KX16"/>
    <dbReference type="GeneID" id="92362604"/>
    <dbReference type="KEGG" id="loi:92362604"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF458">
        <property type="entry name" value="PALMITOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="8">
        <location>
            <begin position="245"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5486050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="509" mass="57628" checksum="9901EDAC561DE984" modified="2021-09-29" version="1">MLMFMFGAVIGTIALIGTFMYIIIMGPSRYHRDGVVGKLHRLLTSVPLNVCGCCVSCFFGCDQRKGRMWCSRCVKHTIRERNWYMVIFYITLVWTVEVLYLLVSLPRLKASIMSKAVSWGLVVLSELLWACATFTDPGTVTAKADMAAQRQQFATKVAADTAKKPLSRQQATCGPGIATQGTALGNSKARRTFLFSPAEEFVLNNRYIVDGMVYAIASDAAAAERTAMQQEYTSPTTGQRVYVGQSCTTCHVPRPSRSKHCRLCNRCVRRYDHHCPWINNDVAERTTRYFLGFLLCHALSCTWACVDLFRSIRQFLMAHHAWGWLLRYPSGFTVPLSFSQYVTILINFHMLDACLIFFAFFIGLMLYGFWCYHMTFAMANLTMNDLNKIDDTVEFVVTLPTLEMVYRESRKVRVRLEQVAERKPKALLALTEPPPPKTEPGYEEGGKENLAYRKRVKKMLVKDLRGLYDRGVWRNLLEIFFPSAPLLDSVVLAKATRCIQQGPGGAEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KYW0</accession>
    <name>A0A836KYW0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">60S acidic ribosomal protein P2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_08239</name>
        <name evidence="8" type="ORF">LSCM4_08240</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">LSCM4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays an important role in the elongation step of protein synthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">P1 and P2 exist as dimers at the large ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000003">
        <property type="protein sequence ID" value="KAG5488015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFHLR010000003">
        <property type="protein sequence ID" value="KAG5488016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066142.1">
        <property type="nucleotide sequence ID" value="XM_067210109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KYW0"/>
    <dbReference type="SMR" id="A0A836KYW0"/>
    <dbReference type="GeneID" id="92364043"/>
    <dbReference type="KEGG" id="loi:92364043"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05831">
        <property type="entry name" value="Ribosomal_P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001859">
        <property type="entry name" value="Ribosomal_P1/P2_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696:SF6">
        <property type="entry name" value="ACIDIC RIBOSOMAL PROTEIN P2, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00456">
        <property type="entry name" value="RIBOSOMALP2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="70"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5488015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5488016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="11060" checksum="8E46AEE6CB5BE6B4" modified="2021-09-29" version="1">MSAETLACTYAALMLSDAGLPTSAENIAAAVKAAGVEVRATLPILFSRFLEKKSVETLMAAAAAQAPTGASAPASAAGAAPAAAAGGKAEEKKKEEPEEEGDDDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836L3S4</accession>
    <name>A0A836L3S4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_08028</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000005">
        <property type="protein sequence ID" value="KAG5487583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065871.1">
        <property type="nucleotide sequence ID" value="XM_067209904.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92363838"/>
    <dbReference type="KEGG" id="loi:92363838"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="11493"/>
            <end position="11551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="11640"/>
            <end position="11702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5487583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="11702" mass="1283835" checksum="C10A18B56DFD252D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FM29</accession>
    <name>A0A836FM29_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sucrase/ferredoxin-like family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_00660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058838.1">
        <property type="nucleotide sequence ID" value="XM_067202737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836FM29"/>
    <dbReference type="SMR" id="A0A836FM29"/>
    <dbReference type="GeneID" id="92356671"/>
    <dbReference type="KEGG" id="loi:92356671"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03062">
        <property type="entry name" value="TRX_Fd_Sucrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000213">
        <property type="entry name" value="APD1p protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009737">
        <property type="entry name" value="Aim32/Apd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902">
        <property type="entry name" value="ACTIN PATCHES DISTAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902:SF14">
        <property type="entry name" value="ACTIN PATCHES DISTAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06999">
        <property type="entry name" value="Suc_Fer-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5465207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="28376" checksum="3CBC417C1F24B9D3" modified="2021-09-29" version="1">MMTTDPNAFEAIKQKLTAQTLQDIEGLDARKYGFGREECCGPIPAKVLGSLKLGEHVFLNTHMPARQWDKRTENVPGFKELSHHLKHKHPDASFTVSHLDKGMDDSILHFKVDSDKKAVAITQYSGVSEPYELPWETKGILAVDRSTEYFVFICSHFSRDARCGFCGSVLVDLFRHAILEKLGAGGAERVTVYSCSHVGGHIYAGNVIIYSRHGGICYGLFKPEDIPGVVDAIAEDQGSIPESLKNRIRGQMGPDAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FVA2</accession>
    <name>A0A836FVA2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histone chaperone RTT106/FACT complex subunit SPT16-like middle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_02680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5469992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060258.1">
        <property type="nucleotide sequence ID" value="XM_067204706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836FVA2"/>
    <dbReference type="GeneID" id="92358640"/>
    <dbReference type="KEGG" id="loi:92358640"/>
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        </location>
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            <dbReference type="EMBL" id="KAG5469992.1"/>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
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            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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            <begin position="216"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G6K9</accession>
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    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466359.1"/>
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    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="92357492"/>
    <dbReference type="KEGG" id="loi:92357492"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469:SF27">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5466359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="903" mass="96519" checksum="E5FA462E0E99D1C4" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G6N3</accession>
    <name>A0A836G6N3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NIF system FeS cluster assembly NifU N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_01555</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
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        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; iron-sulfur cluster biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NifU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067203603.1"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A836G6N3"/>
    <dbReference type="GeneID" id="92357537"/>
    <dbReference type="KEGG" id="loi:92357537"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1010.10:FF:000005">
        <property type="entry name" value="Iron-sulfur cluster assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY ENZYME NIFU HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82649">
        <property type="entry name" value="SufE/NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032615461" description="NIF system FeS cluster assembly NifU N-terminal domain-containing protein" evidence="6">
        <location>
            <begin position="19"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="NIF system FeS cluster assembly NifU N-terminal" evidence="7">
        <location>
            <begin position="28"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5466404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="168" mass="18115" checksum="23E85C6926091C79" modified="2021-09-29" version="1">MRAFSRAGAATMLPAACAAQLSAVRTLYSDKVQDHYKNPRNVGKLDKNDPNVGTGLRGAPECGDMTQMQVKVNPDTLVIEDVRFKAFGCGSAIAASSYASQAIRGKTVADALKLTNKEIAQELSLPPVKLHCSMLAEETIHAAVENYLSKNPTLKSKVSKRKEEANHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G992</accession>
    <name>A0A836G992_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_00914</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059631.1">
        <property type="nucleotide sequence ID" value="XM_067202981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G992"/>
    <dbReference type="SMR" id="A0A836G992"/>
    <dbReference type="GeneID" id="92356915"/>
    <dbReference type="KEGG" id="loi:92356915"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016689">
        <property type="entry name" value="ESCRT-2_cplx_Snf8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040608">
        <property type="entry name" value="Snf8/Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12806">
        <property type="entry name" value="EAP30 SUBUNIT OF ELL COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12806:SF0">
        <property type="entry name" value="VACUOLAR-SORTING PROTEIN SNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04157">
        <property type="entry name" value="EAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="25"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5467829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="385" mass="41921" checksum="DACEE546AB85C700" modified="2021-09-29" version="1">MRRRVGVGHVLQERQQQQRMADLGAQITAERVGQIEDQLEELQAQLKTLARNHKSDIKEDPVVRARFRQLADSLGVDLISSKKNVFADALGLGNFYYQLASRTVEACMQERKFCGAYVPLQRVQFFVQKVYDTSSLLGGSARNHHVSPSNSGSGSKHDSPSEDKRIVISEADILTALSKLSVLGAGYNVVKLGGVSYIQITPDGARGGDHVLLLNYALGLQKEKVEKAKRVALEDQRKNAPVSAVPGSLATAMGRSSHRSGVGAAYALGAHPFDLDNDLSSRPDVSLSLAQQCVAVRESQIASGLHWEAHRARAALRRMVQEGTVWVEELQDESGDNPGPPALSKAVLLSTEEVKRVWKGKHTGTAAAADEEEVVYWFVSLIAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G9P5</accession>
    <name>A0A836G9P5_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5468084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059886.1">
        <property type="nucleotide sequence ID" value="XM_067203236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G9P5"/>
    <dbReference type="GeneID" id="92357170"/>
    <dbReference type="KEGG" id="loi:92357170"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5468084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="119" mass="13462" checksum="5290D5FA2BE537BC" modified="2021-09-29" version="1">MGASILGRSDEDGALSSMWGRLLFLSCMATGTLYVFCGLFACRRLILRDIRWLLMAVLYFSIGVCHAFFTLVLLCFAIACVLFTFEKPMQNGEMIMYSGIMTIITMYFAFGRKTILYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GBG1</accession>
    <name>A0A836GBG1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Kinetoplastid kinetochore protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_03384</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060943.1">
        <property type="nucleotide sequence ID" value="XM_067205391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GBG1"/>
    <dbReference type="SMR" id="A0A836GBG1"/>
    <dbReference type="GeneID" id="92359325"/>
    <dbReference type="KEGG" id="loi:92359325"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="39"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="376"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="230"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5471826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="441" mass="48460" checksum="372BBA393EE5FE41" modified="2021-09-29" version="1">MSAHSYAALRSTTPPLYYRRPEGTAPSYYTVPAREVEGLRIPSSASSHPAAARSNGAPTTTAGECPRPSSSLHPSMDRSAANRAPTATATAPPPPPSPRLSSYIMPSVVNPYSQSASQQPGMAHVAEPVNPASYLQQANAMGRWSYQQPPSQQPQYPTLDPVAARIAAIDAEEAAMAAEEMGLRAKLVELQVARKRQEEEQLHLSHGWAQMLENEERYYTEPVIDLRPEIMAREQQCAMLQNQLQQVEAEALQAQSQLQGTEYILREAESFELDRKRLQDAFQDVERRRRECVARAERYFDVETKRIVEGNKAIRNLDNQLREMTRRGPLAHLQDGNCLPVSSRRSASRAVTFAADKSIVLDLGCDEYASSAEPVAIDDESGGMTNSYTSAHGIAPRDEGNSEYGFSGLPGEDVGGTSVAFSLNDTKDSLVKRRRVEIASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GDA2</accession>
    <name>A0A836GDA2_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_05870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="loi:92361734"/>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5479862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="392" mass="42030" checksum="D4F5957930DFC007" modified="2021-09-29" version="1">MWSQATVAPALASRRLRGGPCSHIAISLRTTTVTLCILAIAVFNTVVVPRAQAAATPAGFRCLRPFSATGTFSNVAKAHPSHNCDFFYFAVEGAAAELKCASSSPAAAAAAVSGETSCNVTVRWSMRRASDAAARLQRQVGADKDYFTREASATSTTTPPTRVRTLNPSAASFVTEDADVWRYAVSLKAKGDSAINYKGFNNGDGYSLCCDALEEADCAWMTPQKGDNDRDCDEDVDDGFASQRSRLLRSCPLPFPSPSSTGDVGGDFGTSLGARVALTDLDEDENSGFFHGVITKPLHRIVEGPWEVIVQMWRRRQRTPQEGTDPSLSIPTDQTIETEVLGRIVVPFTLSLAQLQKQGRITQEPSMVLRVKDVAEVVQMAGDKAAGEAGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GDD0</accession>
    <name>A0A836GDD0_9TRYP</name>
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        <recommendedName>
            <fullName evidence="8">Eukaryotic translation initiation factor 3 subunit 7-like protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="6" type="ORF">LSCM4_02231</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067204265.1"/>
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        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="eIF3d"/>
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    <dbReference type="PANTHER" id="PTHR12399">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT D"/>
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    </dbReference>
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        <property type="entry name" value="eIF-3_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EIF-3_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="99"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="499"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="503"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5472906.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="534" mass="60801" checksum="BEA7FCCC5F961A4D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GES4</accession>
    <name>A0A836GES4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquinol-cytochrome c reductase complex 14 kDa protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_01189</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UQCRB/QCR7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="term" value="C:mitochondrial inner membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:respiratory chain complex III"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome b-c1 complex subunit 7"/>
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        <property type="entry name" value="QCR7"/>
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        <property type="entry name" value="QCR7_sf"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="8" id="KW-0472">Membrane</keyword>
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    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
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    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5466052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="24251" checksum="36E8FB98BAC12B1D" modified="2021-09-29" version="1">MMKPTTPNFMAQGIWAGFRYYIGHFFYPNMYREFLSVQNAHKVERALRLQKAIKANKVDYRALLALPVTDHAHPYKMEYPWEKVMQSDPRDLGFYGKWYASKMMCFYEGLQFHKWGCLQDDLINAHGWWNRAARTRAPKDKIVHGDRRVMRARVLKDKYIYEPKDRWVHPVDNVAYFGPYVMMVADEWEEKWGFFAGQEVEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GHX4</accession>
    <name>A0A836GHX4_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Euglenozoa</taxon>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059774.1">
        <property type="nucleotide sequence ID" value="XM_067203124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GHX4"/>
    <dbReference type="GeneID" id="92357058"/>
    <dbReference type="KEGG" id="loi:92357058"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5467972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="153" mass="17407" checksum="11D55241F52674B2" modified="2021-09-29" version="1">MLRLAAVRLATAPRSGAGVTAAAVGAGCSGQHMNSQQRVLEINSPMSLLRMCYRSIDITVKSRHARSFLKKRLIELWAEKKNETNPEKQRFYMDLAGSFLQALHTERNPKPGKVVSFQLSRRVAYEQKMAEREKSAGVRRVRRMPREEKAQDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GJI7</accession>
    <name>A0A836GJI7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_03505</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061442.1">
        <property type="nucleotide sequence ID" value="XM_067205505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GJI7"/>
    <dbReference type="SMR" id="A0A836GJI7"/>
    <dbReference type="GeneID" id="92359439"/>
    <dbReference type="KEGG" id="loi:92359439"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15853">
        <property type="entry name" value="SNARE_Bet1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039899">
        <property type="entry name" value="BET1_SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="47"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5473439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="138" mass="15602" checksum="746F9E7AF5241F67" modified="2021-09-29" version="1">MIHPQSTLFRRREGGVGDDGALSSPSSSAPHQARPGTAAAAPVHMNASQEQENDALMQALLCDMRRAKKSFTKMGDEVREQNALLERLRASFLTAQNAIRKTMRNLDRVGWGGFRHMWVLAIFVIVFFMLLYLMLHFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GLF7</accession>
    <name>A0A836GLF7_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_04519</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062712.1">
        <property type="nucleotide sequence ID" value="XM_067206503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GLF7"/>
    <dbReference type="SMR" id="A0A836GLF7"/>
    <dbReference type="GeneID" id="92360437"/>
    <dbReference type="KEGG" id="loi:92360437"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5477301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="145" mass="16839" checksum="18FDE29CA46268BE" modified="2021-09-29" version="1">MVFFSTYRSKRIVAPGFLNGPVMTARAFSDYYFQRAWNGCLQWVIPGEMRFWACGIPLIYFIHRYHNDHSLEPDYVEKAMIMRWGGSLEEVRKLSPQDQLRIRAFADIEKLYSAYGPKDTIIQPTGDLLPGKDYYHKSGDAGTHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GM85</accession>
    <name>A0A836GM85_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CNNM transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_02992</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060563.1">
        <property type="nucleotide sequence ID" value="XM_067205011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GM85"/>
    <dbReference type="SMR" id="A0A836GM85"/>
    <dbReference type="GeneID" id="92358945"/>
    <dbReference type="KEGG" id="loi:92358945"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010960">
        <property type="term" value="P:magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045095">
        <property type="entry name" value="ACDP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064">
        <property type="entry name" value="METAL TRANSPORTER CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064:SF97">
        <property type="entry name" value="METAL TRANSPORTER CNNM-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="4">
        <location>
            <begin position="9"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5470297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="435" mass="47938" checksum="CEB893F7BD80306F" modified="2021-09-29" version="1">MKTFFGFAVLVPAPVGALIVIILTCLAGTMAGLVLCVFSLDVTRLSGIAHTGNSADAARARRLVAILGKPHWVLIALLTWNDIALEMVPLVLNTFLPPVAAIVTSVAITLVFCEILPQAFFIQHAFELSALLSPFIRGLMWITAPVAWPMSKLLDAVVGDKEAVFFQRRELREVIRIQDEMGERRRRWKRAEVGEGGGESQGNGEEDLTKEEAKLMLNVLSLSESTAKDMVQLPSEIMYKWHIDTPLSPSLIAEVFAKGYNFIPVYEDADDPTNVTQILMTKMLLLLIYRSESDGVCVRDMQLVPLQRFNGSTMATEVFVHLQRISPSIAAITSEAGDKVVGLLTLRTISEQIHETTFQAEMNPLSPSPMQVMVRSWKAFRRVGEYTISVSSRPSSLNTSFALIPTIPAIERSMRRADSAARLSIVVKTGEASPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GMH2</accession>
    <name>A0A836GMH2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_01715</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059453.1">
        <property type="nucleotide sequence ID" value="XM_067203762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GMH2"/>
    <dbReference type="GeneID" id="92357696"/>
    <dbReference type="KEGG" id="loi:92357696"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051419">
        <property type="entry name" value="Lys/N-term_MeTrsfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176:SF79">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5466563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="32015" checksum="A0B47998223D406B" modified="2021-09-29" version="1">MQCDAGEMNPGRADFWEHFYDQAEGRLQEKERHHRKAREIAARGSLMNHYEWFMEYPLYEAALKACLRAVPTALSHDGPIRVLHVGCGNSDFCDHVEELLSDLNAVSSSSSRPCEVLNVDICENIIAHVALCFPSRLYAVGNCCDLRLTSSPFVPSSNDGAWYSRNTSLQLRAVMQSSADIVFDKGTADALLSSFAGDYNHNMEAYAGEMLKVLRPGGLLFLISINSEDVVNPYVLSAENGLKSFQLEYKDVIELGAQDLRHLRVETLGSRYNCYGYAVVTSAAAKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GMI1</accession>
    <name>A0A836GMI1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.131</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LSCM4_01730</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + 2 GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + 2 GDP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:29523"/>
            <dbReference type="Rhea" id="RHEA-COMP:19515"/>
            <dbReference type="Rhea" id="RHEA-COMP:19516"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:132511"/>
            <dbReference type="ChEBI" id="CHEBI:132515"/>
            <dbReference type="EC" id="2.4.1.131"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:29524"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.131" evidence="3"/>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059468.1">
        <property type="nucleotide sequence ID" value="XM_067203777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GMI1"/>
    <dbReference type="SMR" id="A0A836GMI1"/>
    <dbReference type="GeneID" id="92357711"/>
    <dbReference type="KEGG" id="loi:92357711"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004377">
        <property type="term" value="F:GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000256">
        <property type="entry name" value="GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038013">
        <property type="entry name" value="ALG11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031814">
        <property type="entry name" value="ALG11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45919">
        <property type="entry name" value="GDP-MAN:MAN(3)GLCNAC(2)-PP-DOL ALPHA-1,2-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45919:SF1">
        <property type="entry name" value="GDP-MAN:MAN(3)GLCNAC(2)-PP-DOL ALPHA-1,2-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15924">
        <property type="entry name" value="ALG11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033049266" description="GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase" evidence="12">
        <location>
            <begin position="25"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="ALG11 mannosyltransferase N-terminal" evidence="14">
        <location>
            <begin position="26"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="13">
        <location>
            <begin position="268"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF15924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAG5466578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="466" mass="52346" checksum="44EA981AD9BF1B7B" modified="2021-09-29" version="1">MLTVVSLLWATFALICRYRKRSYAKSTVGFLHPAAGAGGGGERVLWVALEGLQHADAAKGIERQYVVFTNEYAPEDASSTATSDHHLLSLVEKQFSIRLLRPVRFIYLRPAVTRWLSGDAYPHLTLLLQTFWGGAALFYEVAVVNAATPIVIETVGVPFVYPLLRLLAGCTVISYTHYPVISSAMTQRVRSGEVNHTNSPILARNPALRCAKVVYYQIFTLLYRWMGYFPNMVLTNSSWTQNHMKSLFWPRACIRLYAPCDVARFAAESHPPAQRNNRIVSVGQFRPEKNHMLQLAAFHAALPQLPRDAKLVMIGGARNAEDEKRVAQLRARAKELGIEKQVEIIVNATVEVVRAELGRCLIGLHTMRDEHFGIVLLEYLAAGCIPLGHRSGGVELDIINSPDLGFLAVTAEEYAAAMVDIFEMRLRYPERYARFQQRGSDHVKSFDDSSFRTRFVELVSKYIYPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GN15</accession>
    <name>A0A836GN15_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dynein regulatory complex protein 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LSCM4_05526</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the nexin-dynein regulatory complex (N-DRC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Flagellum axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DRC12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5478126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063033.1">
        <property type="nucleotide sequence ID" value="XM_067207465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GN15"/>
    <dbReference type="SMR" id="A0A836GN15"/>
    <dbReference type="GeneID" id="92361399"/>
    <dbReference type="KEGG" id="loi:92361399"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033585">
        <property type="entry name" value="DRC12-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28656">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28656:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="6 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0282">Flagellum</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="20"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG5478126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="163" mass="18734" checksum="04338F81C807A783" modified="2021-09-29" version="1">MPPKAMKGASGVSNQLYYEEHQLADDIAISEERLNALKREYLERMKALAERKEQQLVFAAELEARKAALEAKKIEKADVLTDCTRDYKVREREAVEEIAKQDAVLNALQEAKKKLQDHMDTFGAEFDSQIKNKKKEFESLRERIAEMEKEFAVLLSDVEQCAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GNK7</accession>
    <name>A0A836GNK7_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_04351</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062545.1">
        <property type="nucleotide sequence ID" value="XM_067206336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GNK7"/>
    <dbReference type="GeneID" id="92360270"/>
    <dbReference type="KEGG" id="loi:92360270"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5477134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="71" mass="8303" checksum="48F75420CB7C5499" modified="2021-09-29" version="1">MPNAAVAKMRARSRQNQPRLTEEEKLKRREERELKRSRVPQWLAWSMIVIVIGSSLVNVYLSVVHSPKMTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GNW6</accession>
    <name>A0A836GNW6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">P-type Cu(+) transporter</fullName>
            <ecNumber evidence="2">7.2.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">LSCM4_02415</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.8" evidence="2"/>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059997.1">
        <property type="nucleotide sequence ID" value="XM_067204445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GNW6"/>
    <dbReference type="SMR" id="A0A836GNW6"/>
    <dbReference type="GeneID" id="92358379"/>
    <dbReference type="KEGG" id="loi:92358379"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140581">
        <property type="term" value="F:P-type monovalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000144">
        <property type="entry name" value="copper-transporting ATPase 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF369">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0186">Copper</keyword>
    <keyword evidence="7" id="KW-0187">Copper transport</keyword>
    <keyword evidence="13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="954"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1077"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1119"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1150"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="18">
        <location>
            <begin position="77"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="16">
        <location>
            <begin position="224"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase C-terminal" evidence="17">
        <location>
            <begin position="981"/>
            <end position="1172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAG5469020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1207" mass="129893" checksum="411390B61D0C1665" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GNW7</accession>
    <name>A0A836GNW7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nodulin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_06065</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000011">
        <property type="protein sequence ID" value="KAG5485427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065164.1">
        <property type="nucleotide sequence ID" value="XM_067207990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GNW7"/>
    <dbReference type="GeneID" id="92361924"/>
    <dbReference type="KEGG" id="loi:92361924"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:001014">
        <property type="entry name" value="Nodulin-like, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010658">
        <property type="entry name" value="Nodulin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576:SF158">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 12-LIKE CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576">
        <property type="entry name" value="UNCHARACTERIZED NODULIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06813">
        <property type="entry name" value="Nodulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="462"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="495"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="520"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="556"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="596"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="Nodulin-like" evidence="7">
        <location>
            <begin position="31"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="305"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="327"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5485427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="630" mass="68525" checksum="195FE71708E98BF2" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GP90</accession>
    <name>A0A836GP90_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060207.1">
        <property type="nucleotide sequence ID" value="XM_067204655.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92358589"/>
    <dbReference type="KEGG" id="loi:92358589"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35615:SF7">
        <property type="entry name" value="PRESENT IN THE OUTER MITOCHONDRIAL MEMBRANE PROTEOME 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35615">
        <property type="entry name" value="PRESENT IN THE OUTER MITOCHONDRIAL MEMBRANE PROTEOME 22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1098"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1098"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1123"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1161"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1190"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1222"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1254"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1273"/>
            <end position="1290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5469230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1304" mass="136407" checksum="B1D41A6F510B168E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GQ06</accession>
    <name>A0A836GQ06_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Calreticulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LSCM4_03367</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">LSCM4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 14">Belongs to the calreticulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060929.1">
        <property type="nucleotide sequence ID" value="XM_067205377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GQ06"/>
    <dbReference type="SMR" id="A0A836GQ06"/>
    <dbReference type="GeneID" id="92359311"/>
    <dbReference type="KEGG" id="loi:92359311"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.250.10:FF:000002">
        <property type="entry name" value="Calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.250.10">
        <property type="entry name" value="Calreticulin/calnexin, P domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001580">
        <property type="entry name" value="Calret/calnex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018124">
        <property type="entry name" value="Calret/calnex_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009169">
        <property type="entry name" value="Calreticulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009033">
        <property type="entry name" value="Calreticulin/calnexin_P_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073:SF2">
        <property type="entry name" value="CALRETICULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073">
        <property type="entry name" value="CALRETICULIN AND CALNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00262">
        <property type="entry name" value="Calreticulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002356">
        <property type="entry name" value="Calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00626">
        <property type="entry name" value="CALRETICULIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63887">
        <property type="entry name" value="P-domain of calnexin/calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00803">
        <property type="entry name" value="CALRETICULIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00804">
        <property type="entry name" value="CALRETICULIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CALRETICULIN_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="10 11 14" id="KW-0143">Chaperone</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 11 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0430">Lectin</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 14" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
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    <feature type="chain" id="PRO_5033096884" description="Calreticulin" evidence="14">
        <location>
            <begin position="24"/>
            <end position="395"/>
        </location>
    </feature>
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        <location>
            <begin position="204"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="360"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
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        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="360"/>
            <end position="369"/>
        </location>
    </feature>
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        <location>
            <begin position="370"/>
            <end position="383"/>
        </location>
    </feature>
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        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>an alpha-D-glucoside</name>
            <dbReference type="ChEBI" id="CHEBI:22390"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>an alpha-D-glucoside</name>
            <dbReference type="ChEBI" id="CHEBI:22390"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>an alpha-D-glucoside</name>
            <dbReference type="ChEBI" id="CHEBI:22390"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>an alpha-D-glucoside</name>
            <dbReference type="ChEBI" id="CHEBI:22390"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>an alpha-D-glucoside</name>
            <dbReference type="ChEBI" id="CHEBI:22390"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="106"/>
            <end position="137"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010983"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
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        <source>
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        <source>
            <dbReference type="RuleBase" id="RU362126"/>
        </source>
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    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5471812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="395" mass="44465" checksum="5BCF22EF4612693A" modified="2021-09-29" version="1">MAQRATLAAILGVLILCVSLGQAEVFFHEEFNTMDGWVQSEHSSDYGKTGLSAGEMHVDAEKEQGLKLMEDSKFYSISKKLPKPVSNENKPLVISYSVKNEQKLTCGGGYLKFFSKLDQKDLHGESPYWLMFGPDVCGAKKLVHIILNYNGKNHLWKKTLPPKDGKATHVYTLQIAPNNTYQLYLDGTYALAGSLEEDWEILPPKSIPDKSVKKPEDWVDDDMIDDPNDKKPEDWDNEPATITDPDAVKPEDWDESEDGEWEAPQVPNPKHRGPWKPRRISNPDFKGVWEPPQIPNPEYKDEPNLYRTPAPLQYVGIDVWQVEGGTIFDNIIIGSDLEEVLAVVKSTYGVMAEKELELVQEQEKEEAKLQAESSKNAESASSSEDSHDTDAEEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GQL2</accession>
    <name>A0A836GQL2_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_02700</name>
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    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Trypanosomatida</taxon>
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            <taxon>Leishmania</taxon>
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    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060276.1">
        <property type="nucleotide sequence ID" value="XM_067204724.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="loi:92358658"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="Ycf3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44858">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 6"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR44858:SF1">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE SPINDLY-RELATED"/>
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    </dbReference>
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        <location>
            <begin position="186"/>
            <end position="219"/>
        </location>
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            <begin position="1"/>
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    </feature>
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        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5470010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="759" mass="82755" checksum="B26214C84BFB8A3B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GR48</accession>
    <name>A0A836GR48_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_04603</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
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            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067206586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GR48"/>
    <dbReference type="GeneID" id="92360520"/>
    <dbReference type="KEGG" id="loi:92360520"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
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        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
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    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
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        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="PH_domain"/>
    </dbReference>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="703"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="448"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5477384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="961" mass="109326" checksum="2F690FDA97DA6C6C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GTL4</accession>
    <name>A0A836GTL4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063605.1">
        <property type="nucleotide sequence ID" value="XM_067207832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GTL4"/>
    <dbReference type="GeneID" id="92361766"/>
    <dbReference type="KEGG" id="loi:92361766"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="331"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="396"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5479894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="471" mass="53511" checksum="AB36D3105BDE672A" modified="2021-09-29" version="1">MIALHTHAVLSSSFSSSIWPNRGAAVDDGHSGACVMRRGVPHVERLPRELLLDVFIDVIRNDGDNFAWIGVLSSVCRSWCQLCQHTVLWEYVAKRICVVYPLVVRLHSSAAYDATSREMVNRMCLLEAEEQRMVQHDSLQPLPAPSRATLRQTMEKVRRYRESQQYYKYVQRRRHVVLHFFLSITLFSVALAITMAMCVSEGFDLGGFCTTTIVFGLLWVAYLCIVAIIVSNVVMQAHFEPLPLLMRLRRNKLLIAASAVTIILGICDVIIPTLLIQINLARKERFSWLWCGITVILSFCLWQLYTLIYIMPAARQQLRYQMANVNVRAGFQFVVLNIPNGFPFLFAAASFCTLQYVQYGYRIYILLGGVPVIVSLGVLALVFLLDFYSLHRFKDLTMGTCLFLAMLFPISLLVWEFRGLSLLPLVAAAFGVFFAHARYVVGSAIHELMRTIRAERNGSILRTPDPTKKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GUF8</accession>
    <name>A0A836GUF8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_02782</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the exportin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060354.1">
        <property type="nucleotide sequence ID" value="XM_067204802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GUF8"/>
    <dbReference type="SMR" id="A0A836GUF8"/>
    <dbReference type="GeneID" id="92358736"/>
    <dbReference type="KEGG" id="loi:92358736"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000610">
        <property type="entry name" value="Exportin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041123">
        <property type="entry name" value="CRM1_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041235">
        <property type="entry name" value="Exp1_repeat_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014877">
        <property type="entry name" value="XPO1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040485">
        <property type="entry name" value="XPO1_repeat_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="EXPORTIN 1/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223:SF2">
        <property type="entry name" value="EXPORTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08767">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18777">
        <property type="entry name" value="CRM1_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18784">
        <property type="entry name" value="CRM1_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18787">
        <property type="entry name" value="CRM1_repeat_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01102">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="7">
        <location>
            <begin position="34"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1002"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1002"/>
            <end position="1017"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5470088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1038" mass="118366" checksum="1E8255D7B9EDDFA5" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GUY1</accession>
    <name>A0A836GUY1_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_00016</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058209.1">
        <property type="nucleotide sequence ID" value="XM_067202108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GUY1"/>
    <dbReference type="SMR" id="A0A836GUY1"/>
    <dbReference type="GeneID" id="92356042"/>
    <dbReference type="KEGG" id="loi:92356042"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36706">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5464578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="155" mass="18666" checksum="315E1C634FD60FF5" modified="2021-09-29" version="1">MNGTPHFKRIRDTPETLNPVTGRSIYYGMRPWRCDDRFQDWLKSFTCFDSVGVQYSLIKLFVQCARSDEGQEPIDNYHRLGRGEVMYYVERYRSGMMRTRVLETYPYDQNELRRIAEEDGLKMRVWRHQRELEMESREGKIDKVLQMNVMPRGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GV72</accession>
    <name>A0A836GV72_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_05715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063420.1">
        <property type="nucleotide sequence ID" value="XM_067207647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GV72"/>
    <dbReference type="GeneID" id="92361581"/>
    <dbReference type="KEGG" id="loi:92361581"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110296">
        <property type="entry name" value="Oligoxyloglucan reducing end-specific cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5479709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="490" mass="52131" checksum="5D4A8CAE23EE5A96" modified="2021-09-29" version="1">MSLATELAGLVRRLSPQAYERVVLLLHCLLSSEEDHGTRNPQALSLQAICDVVLCACPGPVPRFLFVLSNNDKLLRSADCGLTWRLCFSRSSEPRQASRGGAQDLLDDVMSLLKSTVDTEDVAGREVSSVVCCADGYGDVVALCGRSGFLAVSGDKGVTFTTATNYLMNEFGERAHLRHICVLDTDRILVSDGLRVVCVTVECAGYGPLALGKARVALVCATQVCMLHACCIGGRARSAVVAENGRLHLSLDGANSFMEVRHCLGRIRGFSTAAALRHCELPDFPQAALASSMDMSSTEASASPPRPDSAYDYVTGYKCDASAREGESATAVAQFEAGALRYGADVFYRFFFVVGCGTEVLPYDYSAVLCVCTRRDSDHIAVMSTASYVSYVPFSQSRAHDRLLCALTRSSDGGGSYIASRGSVVGTSVSHDLGNWSPPRGAAPVGLLAVGGGSILACGRNKVVSRVGEDEGRTILKDMRLPVLTTAFPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GVC6</accession>
    <name>A0A836GVC6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Methionine aminopeptidase 2</fullName>
            <shortName evidence="9">MAP 2</shortName>
            <shortName evidence="9">MetAP 2</shortName>
            <ecNumber evidence="9">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LSCM4_05807</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9 10">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9 10">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="9">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="9"/>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063510.1">
        <property type="nucleotide sequence ID" value="XM_067207737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GVC6"/>
    <dbReference type="SMR" id="A0A836GVC6"/>
    <dbReference type="GeneID" id="92361671"/>
    <dbReference type="KEGG" id="loi:92361671"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01088">
        <property type="entry name" value="MetAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000370">
        <property type="entry name" value="Methionine aminopeptidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03175">
        <property type="entry name" value="MetAP_2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050247">
        <property type="entry name" value="Met_Aminopeptidase_Type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002468">
        <property type="entry name" value="Pept_M24A_MAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018349">
        <property type="entry name" value="Pept_M24A_MAP2_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00501">
        <property type="entry name" value="met_pdase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777:SF2">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01202">
        <property type="entry name" value="MAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="12">
        <location>
            <begin position="153"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG5479799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="464" mass="51085" checksum="9BDEFA4163E9C7C2" modified="2021-09-29" version="1">MPPKSSAKNKQQPKQQGGSKKGKGSSDDGDDFDAMLAAAVSATMAGTAKNHSNSNQRKHNNGNSSAPANKSLAADEPVVPSSADHPENPYPQTAAGYPRQTWPEPTVPVSKQFAAGRFPAGEIVDHPGEMNCFRRSSEEKRALARANEQQLQEMREAAEVHRQVRAWAQSWIKPGLSLMLMTDRIEKKLNELIGKDGIVRGQAFPTGCSLNHVAAHYTPNTGDEKIVLAYDDVMKVDFGTHINGHIIDCAWTVAFNPMFDPLLQAVKEATYEGIKQAGIDVRLGDIGAAIEEVMESHEVEINGKVHHVKSIRNLSGHNIAPYIIHSGKSVPIVKGGEQTKMEEGEVFAIETFGSTGRGFVNEDLDCSHYMMRPGAEVMQLRSEKAQQLLKHIQKSYSTLAFCRKWLDRDGFDRHLMNLNRLVDEGAVNKYPPLVDVKGSYTAQFEHTIYLGPTAKEILSKGNDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GVK4</accession>
    <name>A0A836GVK4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Clp1 P-loop domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_00401</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058584.1">
        <property type="nucleotide sequence ID" value="XM_067202483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GVK4"/>
    <dbReference type="SMR" id="A0A836GVK4"/>
    <dbReference type="GeneID" id="92356417"/>
    <dbReference type="KEGG" id="loi:92356417"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF17">
        <property type="entry name" value="POLYRIBONUCLEOTIDE 5'-HYDROXYL-KINASE CLP1 P-LOOP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clp1 P-loop" evidence="3">
        <location>
            <begin position="110"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5464953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="452" mass="49296" checksum="D68A11F19A1EDBEC" modified="2021-09-29" version="1">MPPKKRSSRRLTLNAGEEYTLVGDGAVQVTLQSGLLDVAGVMLDANRPYTFYLHTDRQAITLFTLEGAACLLSSDNRVDTHRGVARAGKLVQVTRRTLLAAKHTKVLVIGRSRSGKTLAAHTLCNLLTRYGNDKKGVFLMDLNAESNCLYAPGCVSCIQVSEAPLWPGLTASPKFLPLSLYTGAAVRPSASSVNSLLHYYDQLHETVMGYIQELSGAAAVVAQQQAPSPYSSSLSEPGSHVVVDAPAPLADLQEGAWYKKLIEVLRPSHVVIVSSREDGEERWSTFLQEDVQRVLPDCEFLFTDPVAYPCERSSCRELLREYFTGTPFYSLGCSKVVVPLKSLTFVEETSEGSVPGSADGVSMRVVHPNASFQALVCALSHAELLEEAPLAPIAGLVTIVYVDEKNEEVAMLIPAAEEPLLRRLIIVPQPRYRDTLRMTSAQVTAMEEYVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GWE8</accession>
    <name>A0A836GWE8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PPIase cyclophilin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_07090</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000018">
        <property type="protein sequence ID" value="KAG5481379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064058.1">
        <property type="nucleotide sequence ID" value="XM_067208995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GWE8"/>
    <dbReference type="SMR" id="A0A836GWE8"/>
    <dbReference type="GeneID" id="92362929"/>
    <dbReference type="KEGG" id="loi:92362929"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000073">
        <property type="entry name" value="Putative cyclosporin 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF6">
        <property type="entry name" value="SPLICEOSOME-ASSOCIATED PROTEIN CWC27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="4">
        <location>
            <begin position="1041"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="34"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="248"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="734"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="974"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="252"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="974"/>
            <end position="989"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5481379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1198" mass="126186" checksum="4FE25405984B83B6" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GWH1</accession>
    <name>A0A836GWH1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tetrapyrrole methylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_01526</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059266.1">
        <property type="nucleotide sequence ID" value="XM_067203575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GWH1"/>
    <dbReference type="SMR" id="A0A836GWH1"/>
    <dbReference type="GeneID" id="92357509"/>
    <dbReference type="KEGG" id="loi:92357509"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1010.10:FF:000007">
        <property type="entry name" value="Ribosomal RNA small subunit methyltransferase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="entry name" value="Methyltransferase, Cobalt-precorrin-4 Transmethylase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008189">
        <property type="entry name" value="rRNA_ssu_MeTfrase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46111">
        <property type="entry name" value="RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46111:SF1">
        <property type="entry name" value="RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tetrapyrrole methylase" evidence="7">
        <location>
            <begin position="94"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="376"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5466376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="459" mass="50496" checksum="F43D24C44CC62EED" modified="2021-09-29" version="1">MGMWGWSGSRFATTWHLRRGIPAPCPAPAQRSHACASRASPASSSVVAFLTPVRRLSGTPRRFSGTFHYRKARLTPEDALDPLSKPTNIDKAALHVVSVPIGNLKDFSLRALDVLRGVDYIITTDRPATKTLLDLVNIPNQGRLIHYSRGNRSTSREKLVELLKGGRSMALVTTSGTPCIGDVGGELVQEIQQSGVRVTAVPGASALMSALAVSGLTTSPYESTKNSQRGGDSDVGLSPPTFEDGSFFFGNVLPKSHGARLRILRTIVASATFPCVFYEVPRRLLMVLQDIAAVMPHRRVYIAHELTKLNESLHADTAERLVGFYLRQEAQMLVKKGQLVLVIAGAGPKETAAWLEKEAAKRRRLRRTVSDLMMSTPPASSQLGCARGSGEARAAESLPGEPRATGAKEEWQQRKRCRAELRRLRQRKRRELLIRKIESEQERLRISLAINRNDATRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GWJ3</accession>
    <name>A0A836GWJ3_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059296.1">
        <property type="nucleotide sequence ID" value="XM_067203605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GWJ3"/>
    <dbReference type="GeneID" id="92357539"/>
    <dbReference type="KEGG" id="loi:92357539"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5466406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="196" mass="21056" checksum="FBA4A4F7215BC3C2" modified="2021-09-29" version="1">MSRDTERLDTCENAAAYRVASLLQRGRTHDDPDAGSLRGMTAQVERFLATAPLEPAVRIEPECMRPGSNSTKEVSTADEGPTVQLNVVAGVLEEVDGAVEWSGMARLGGLVLPTAANQQELQRRKAEQAQAMLDLLSALSPTAPALSDSRGDPRTPALPPSSDDDDVAVMNVDDLMEEDSSEDEAPARLQRIVEMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GYH3</accession>
    <name>A0A836GYH3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_01740</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059478.1">
        <property type="nucleotide sequence ID" value="XM_067203787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GYH3"/>
    <dbReference type="SMR" id="A0A836GYH3"/>
    <dbReference type="GeneID" id="92357721"/>
    <dbReference type="KEGG" id="loi:92357721"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF649">
        <property type="entry name" value="ACID TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="6">
        <location>
            <begin position="12"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5466588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="410" mass="45012" checksum="7C0AD547F50507F3" modified="2021-09-29" version="1">MRLWNHFSGCGVVGAALNLSVTTIGAGMLVIPSTFQDGGIFLVLGVLTLVGLLTVLSIDYLIRCVDRLQLRSYEDISRELLGRWCEEAVRWILIIYNVGIAAGYIVVIGEIFTPMLPLIQPYLPFLTDSTHVMIVAWAFVMLPLSCIPKLTKINYISLVAITATFLISGIIVYRYFAPFDGAPNQAKVTYLSLSKRSLLSLPVMMFSFDCQSLVFQVYSNLKTVTRTNMRRVASLSVAITGLLYLLVGLFGYLTNTPNITGNILINYDPLKDHLFAFGEALYSLTVITAYILVLFPSRDAIFIFLFGYNTATHELSHGAITTRQNLIASILLSTLSIVLATRVTGIVAIIALLGGLCSSTLCFSYPAAFRIMLHVRGLDRCRPMEFVAAICMLVFGVLSGIIGTAIAIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GZL1</accession>
    <name>A0A836GZL1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_07304</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000015">
        <property type="protein sequence ID" value="KAG5483089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064585.1">
        <property type="nucleotide sequence ID" value="XM_067209202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GZL1"/>
    <dbReference type="SMR" id="A0A836GZL1"/>
    <dbReference type="GeneID" id="92363136"/>
    <dbReference type="KEGG" id="loi:92363136"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="61"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5483089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="550" mass="59194" checksum="44EF9D0030BEAEA2" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H039</accession>
    <name>A0A836H039_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059737.1">
        <property type="nucleotide sequence ID" value="XM_067203087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H039"/>
    <dbReference type="GeneID" id="92357021"/>
    <dbReference type="KEGG" id="loi:92357021"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5467935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="294" mass="33469" checksum="F280EB57C443A432" modified="2021-09-29" version="1">MASAKDRGREPLTAIHGRQDRVFPELPVRHPLSVRRREVQRFRNGDGTHHRRAWNPSTKDELHPFPQPAHSNTTTCYNGVDVVTTHFPETVKGTAFLKIQETVLPAVWTRNRDRARASTIRHTYRCEALEHQEGPLSYLAAVIRDDNNPEKRRRQERWCASTTLEGFRGNRFLAPAVEDSSHAEAHRERTRTLTARLRGGYVTPYNRVKQLNASLKAQNELQQKAAAESLVGFYATQPGPAAFKMSNADEWWDLDPVEVTRDMTKRAEAIKSNPYSTLFRSTVLASTLSDPPHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H251</accession>
    <name>A0A836H251_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine/threonine specific protein phosphatases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_07991</name>
    </gene>
    <organism evidence="3 4">
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                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="630"/>
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        </location>
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        <location>
            <begin position="112"/>
            <end position="565"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="630"/>
            <end position="639"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
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    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
            <dbReference type="EMBL" id="KAG5476295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="832" mass="93556" checksum="929C904DDCCED9D1" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        </source>
    </evidence>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="621" mass="68157" checksum="15612360376AEA20" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H403</accession>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="EMBL" id="JAFHLR010000011">
        <property type="protein sequence ID" value="KAG5485414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="92361911"/>
    <dbReference type="KEGG" id="loi:92361911"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5485414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="335" mass="34648" checksum="2FE4B8DB2CF424B0" modified="2021-09-29" version="1">MSPIFVEVYALALKALDPAAWELFGALEDRILHSAACLLSQVELAALRPAVMDGLTAGSPTVASCAHSAVTSGVRGAGATGAASVAADVLQYLRETLQAGIFSTFEMRFDSPTTSAPARLVKDLSRVRQQVASAQSPSSLRCRGLVLAELNNLCQSVLVLSALWMSTKFWATLSETSTLSGLIACFLRLSLPSKEVATVGSAILGGGTLEPASRSEPGSSTVGASVVVPVEQANTDALCLASTPPSSPLASVPPEARSRAEMCSVRVGAASGCDGGATRVSGERVVNSCGDISLDPLAHLAWLDGDVPEAAESLARDVEDTEMILLRCSDYTIPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H4A4</accession>
    <name>A0A836H4A4_9TRYP</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    </gene>
    <organism evidence="2 3">
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            <taxon>Leishmania</taxon>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG5474873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067206042.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="92359976"/>
    <dbReference type="KEGG" id="loi:92359976"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        </location>
    </feature>
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        <location>
            <begin position="305"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5474873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="493" mass="53326" checksum="D9A8FE8B8070AC69" modified="2021-09-29" version="1">MASVCFSSASRSSACDCCECGVVVGTESAQRASLLLPCQHVLHMGCVEFIRRRGKVLMGMDSTDLPLDEENGSASVNSAGKTDLVLRGPGNNSWTRYTHGFCVCPACSTAITRIIPLYLSSTNDNARADPTDSAPTPSQVASEASATAEAEYRRVHRAQKHVLYRLRSLCDQRRRVTELTHACANLHEQRARYLAEVEREERCFPGLTHSGGLLDADSRVGSSSAVASNSVASLAVEHMGVTELELFMAQATPQLLRTQAELRKERHVIERRTKRLNALRMHYHSAKELRALDEAIARREVHTRCNTGDAARHSTSVRPEHLQRAPTHVVKGAPRSQEAGPPSSSSATSGTEGATAASRKRHRGDAAIDVDVEVSPDVVEVLSGEESGADDSGSPADVTVLDVDENTASDADVRDGGNEAVFVSMKDDGTYADESVYEAPYLIPRCFRHATASLPPAAGSAVVPKASTSAVTQHHLRLLPRREARLWQPSLQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H772</accession>
    <name>A0A836H772_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060787.1">
        <property type="nucleotide sequence ID" value="XM_067205235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H772"/>
    <dbReference type="GeneID" id="92359169"/>
    <dbReference type="KEGG" id="loi:92359169"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5471670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="569" mass="58535" checksum="BB564B06EE528E09" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H7U8</accession>
    <name>A0A836H7U8_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H7U8"/>
    <dbReference type="GeneID" id="92359172"/>
    <dbReference type="KEGG" id="loi:92359172"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="116"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5471673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="140" mass="14447" checksum="06A8592BAE92B3AC" modified="2021-09-29" version="1">MRRCCFVSASFSNRGCSECFLSASLEVARKASRSAAFEERLPKATGRSPDEAGPSPSVSGVGAFVAVKATFTSDGVRGLLGGTAVEVGLLSPFARADGAAEDQEVGTSGRVGRAAVDSKLEGLEEDIRGESSSESARQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H919</accession>
    <name>A0A836H919_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RanBP2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_05813</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067207743.1"/>
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    <dbReference type="KEGG" id="loi:92361677"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="278"/>
            <end position="307"/>
        </location>
    </feature>
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        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5479805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="693" mass="73147" checksum="25B5BBEEDF175746" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H9M4</accession>
    <name>A0A836H9M4_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
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            <taxon>Trypanosomatida</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061296.1">
        <property type="nucleotide sequence ID" value="XM_067204259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H9M4"/>
    <dbReference type="SMR" id="A0A836H9M4"/>
    <dbReference type="GeneID" id="92358193"/>
    <dbReference type="KEGG" id="loi:92358193"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5472900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="206" mass="22510" checksum="9EB219D39A4088C7" modified="2021-09-29" version="1">MAASLSPSRSACSTPFHASPVNAVEDFRESDRPLLSLIALCAAQSTIARSAEVVLDALLTPITTPSSPSVSPTPAANGGNGADRLSDRYPEVRVLLHLHHLRCALRDLQECPPHARRTFFSLIQEHLTALAAVLPEPLFTAIASVLQRFLAMNTDEALAKDRCHVLEVQLMHIVEATQTELLRATERLRVRAGVVTLSFHHDIPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HAN9</accession>
    <name>A0A836HAN9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calcium-transporting P-type ATPase N-terminal autoinhibitory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_03491</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Euglenozoa</taxon>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061428.1">
        <property type="nucleotide sequence ID" value="XM_067205491.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92359425"/>
    <dbReference type="KEGG" id="loi:92359425"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024750">
        <property type="entry name" value="Ca_ATPase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12515">
        <property type="entry name" value="CaATP_NAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcium-transporting P-type ATPase N-terminal autoinhibitory" evidence="2">
        <location>
            <begin position="168"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="343"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="380"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="501"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5473425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1303" mass="140107" checksum="BFCEADC1ABCCDBF6" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HAV6</accession>
    <name>A0A836HAV6_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_08243</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000003">
        <property type="protein sequence ID" value="KAG5488019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066146.1">
        <property type="nucleotide sequence ID" value="XM_067210113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HAV6"/>
    <dbReference type="GeneID" id="92364047"/>
    <dbReference type="KEGG" id="loi:92364047"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032987424" evidence="3">
        <location>
            <begin position="21"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="616"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="644"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="702"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="745"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5488019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="899" mass="94742" checksum="F4DB522B1573B150" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HB92</accession>
    <name>A0A836HB92_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RNA polymerase Rpc34 subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_03587</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061521.1">
        <property type="nucleotide sequence ID" value="XM_067205584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HB92"/>
    <dbReference type="SMR" id="A0A836HB92"/>
    <dbReference type="GeneID" id="92359518"/>
    <dbReference type="KEGG" id="loi:92359518"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000734">
        <property type="entry name" value="RNA polymerase Rpc34 subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007832">
        <property type="entry name" value="RNA_pol_Rpc34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016049">
        <property type="entry name" value="RNA_pol_Rpc34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12780">
        <property type="entry name" value="RNA POLYMERASE III DNA DIRECTED , 39KD SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05158">
        <property type="entry name" value="RNA_pol_Rpc34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5473518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="447" mass="48144" checksum="6C78A023EB99138D" modified="2021-09-29" version="1">MSVSSMTVEQRILHRLSTSAEEAIPYERLKKELQLGSSGGEGAVRHLMEQNRVRLCRGNGGDAQIYISIVNDINENLSLVLDAVRASGSSGIDQSQLLSKVRMPKTELGKALAALTAKSLIKEHRSFTNRAKRIYTLFNIDPSSHITGGAMYCGEELDVTFVDEWRRELTRFVSTRRMVSFDQIKRHVEAVQSAGRAHGAGMASSTPGLAANHLPSSPSQSYNLPVIFTMIDSTPQRLVGGSVSSLASGVASTGSSYAFVAKQLSDLDLRILVHTLVLDGVLEMLIPATTEGVNTPQYQLAHGQSVMRHFTVQARRPRQRSLPTRVEGPALQRARKEDDLAPGLPVHPSAAPTFSPSTDAAGIGSGLVSDIEGDGPSSSTMEALRQSSLWEPAPVSQPSAKDAVDGWSYMPAVGFPCLGCPLLEQCSASCRGVVNPKSCTYLKDWLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HBB0</accession>
    <name>A0A836HBB0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_03617</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061551.1">
        <property type="nucleotide sequence ID" value="XM_067205614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HBB0"/>
    <dbReference type="SMR" id="A0A836HBB0"/>
    <dbReference type="GeneID" id="92359548"/>
    <dbReference type="KEGG" id="loi:92359548"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015854">
        <property type="entry name" value="ABC_transpr_LolD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24220:SF86">
        <property type="entry name" value="ABC TRANSPORTER ABCH.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24220">
        <property type="entry name" value="IMPORT ATP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="86"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="404"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="375"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5473548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="459" mass="49038" checksum="0CCAF84B8C558FF8" modified="2021-09-29" version="1">MSAAAAAVKTPATVGTTSLSSGKLRMGGDVSYTTSDEARQSRDSLLAGASLSEKSRQAILQSEPVVLRLRHVGKSYPIAGSDERVAALKDITLAEPEESGAASAALTASAERSLKRGGLPLPFGPVRRGEFVMIRGPSGGGKTTLLNIIGSIDSCTEGTIELNGRVIDKATKESVLADIRLTTLGFVFQTFNLIATMTAAENVELPMTLLGKLSPKEMRLRSRQLLTLVGLRNRINHLPSELSGGEQQRVTIARSLANSPSLLLLDEPTGDLDTANTIEVMDLLMRINRRTKTTCIMVTHNSDIECYADRILYVSDGRFAKEVFNSLPTCLNLEAYRKFLAAKEKAIVGFREGESNEGYSEPDAMVKLTAGGTVDKGDKGHETQRASSSLMTTQSIPETVAATMPSEAASSRGPQAAAMASSAERVSQALQGSTHYRGAFVPPAAVSSLRQREATEYRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HBG6</accession>
    <name>A0A836HBG6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_03708</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061641.1">
        <property type="nucleotide sequence ID" value="XM_067205704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HBG6"/>
    <dbReference type="SMR" id="A0A836HBG6"/>
    <dbReference type="GeneID" id="92359638"/>
    <dbReference type="KEGG" id="loi:92359638"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5473638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="441" mass="48076" checksum="F2A12C2DA86927C2" modified="2021-09-29" version="1">MAKAARTTRHYVSDCLENRYPYDPRRGFAGAREREAGRVFNGYDSCGVDHMMNSLMDPSVSPDEKSRAVHLLYARSASQETKVEILKKGMVPLLIATLQHSPDLLLTHQCLLLLRSLAILPQGCFALIREGAMPVVSAALLTDSPSTESSEAAHHCCVAAAHIFYQVSSNMSGLRWMLGLPHDPAFEGIEAAWVGDALSPEELVSSIADGLAGETTPAKATVYLVQTLARFTSLERGVEAFLAIPDAVDVLVALLGHFQRFPVQDPELCRATLEVVWNTSLGHVGGAAMEARGVPDILFESLGSVSGSVAQVPVCVQRQLTGALSAVCQLTSVKQSSTRAVSSAQARTRIIVLIECVREWNKFIAAKYTSAAKPVPSDAAAVVTNLVQCIRLASELKPVRDITHTFVDAMEEEDATEAFYFRRQLYFHTRWEAEYRASVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HD30</accession>
    <name>A0A836HD30_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Radial spoke protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_04123</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the flagellar radial spoke RSP3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062049.1">
        <property type="nucleotide sequence ID" value="XM_067206112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HD30"/>
    <dbReference type="SMR" id="A0A836HD30"/>
    <dbReference type="GeneID" id="92360046"/>
    <dbReference type="KEGG" id="loi:92360046"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009290">
        <property type="entry name" value="Radial_spoke_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21648">
        <property type="entry name" value="FLAGELLAR RADIAL SPOKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21648:SF0">
        <property type="entry name" value="RADIAL SPOKE HEAD PROTEIN 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06098">
        <property type="entry name" value="Radial_spoke_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0282">Flagellum</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="86"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="225"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="312"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5475541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="41802" checksum="C74F549DB5A75AB4" modified="2021-09-29" version="1">MQRPTTGSEATAAAYTFRQPPQGFQEPKYRDPSSSRNASRNMFSGSRRLGNVMYDRRVYRGNTYATPIMSIAARAEMEKREMIDTQRRKQASQRAASIKRRKQIEAARRHMATPDPGDGRLNTQIQTDEYLEELTDKVVQEVQETQTDPLMDRPATPKYVPTKSGRDAETQIYEGDLFRFDEAVEPILEVLVGKTLEQAMLEVMQEEELELLRQQQIEFEQRRKEELLETQKLEAEERRKFEEKERRKKQEVERIQREKETREKLQARQFAKAYMSNMENRVFSRLQDEGWFADRVLNEVELDFFPWLMAEVDKELAKKKKARDLVDELIREVVRLNATQLAKSRSAGAAQEGPVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HD75</accession>
    <name>A0A836HD75_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histone H2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_03756</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="8">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the histone H2B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061689.1">
        <property type="nucleotide sequence ID" value="XM_067205752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HD75"/>
    <dbReference type="SMR" id="A0A836HD75"/>
    <dbReference type="GeneID" id="92359686"/>
    <dbReference type="KEGG" id="loi:92359686"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000084">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055333">
        <property type="entry name" value="HISTONE_H2B_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00357">
        <property type="entry name" value="HISTONE_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5474583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="142" mass="15806" checksum="FEE9D5646672B710" modified="2021-09-29" version="1">MPPTKGGKRPIPLGGKGKGKRSAGKAHKSGSDHKRRRNQKRSQHWDLYIHRALRRFFKRGTLSKAAVRVLSSFIEDMFNRIQTEAVFVAKINKVKTLTAREIQTSARLLLPPELAKHAMSEGTKAVAKYNASRGEAYAQGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">LSCM4_04338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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            <end position="80"/>
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            <end position="113"/>
        </location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="454" mass="49858" checksum="C3C2451D8DB66A29" modified="2021-09-29" version="1">MQRATRPQGAPSVGARRAEKGPVLPSLRKDFASARKSPEAAARSAWLTNFFERLSSESVTARQSARPDEDFTEGFTDEVVEGLPSPTLRSRRQPLPTSAPFHHAANGAGSSSTGGVVLRNDGAVVLSASCRGLPDVFREQAQTVRSMEMTAAEMQHTLQQLHQYLTLHARRRIEEEHDAGGHSVSAARRRPSADWASIAPLTGEAAALQQHAVADSDSLSEAVRIRRARAAAADEGDSDDQSVEDYAVDYKLPPLTSDSRLADEVAAIVACMAKMNESVKVMCDTEAALPSASTAPWWSSALRMRDMKASAARLGYHARTALSWSHRSLEQLLLQAVILNNASVDTRTQLLQQQQHRQEFQARLRHGQQTVTELQSDIAHCQGRLQAELARRAALQEELCLRARERCLLDPDDHNPLKAELALLLAEREWPSPALKRDARIVLNSLRSISMALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HGB5</accession>
    <name>A0A836HGB5_9TRYP</name>
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        <submittedName>
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        <name evidence="2" type="ORF">LSCM4_05228</name>
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    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067207178.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="92361112"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0033314">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR10763:SF26">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
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            <end position="42"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="640"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5476248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="881" mass="93100" checksum="53613DAEE6DCB6E6" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HHQ6</accession>
    <name>A0A836HHQ6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isochorismatase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_07365</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">LSCM4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000008">
        <property type="protein sequence ID" value="KAG5486437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_067209260.1"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A836HHQ6"/>
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        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
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    <dbReference type="InterPro" id="IPR036380">
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    </dbReference>
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        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR14119:SF3">
        <property type="entry name" value="ISOCHORISMATASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="23"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5486437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="223" mass="24725" checksum="C8E627E086B04A10" modified="2021-09-29" version="1">MPRSALISSRSKLLQKFDRCRTIFMCCDIQEKLRSRIPNFHAAVDVSNTMASFHEVMTPEHATFVATEQYPVGVGHLVKDIHLPAGTPVIEKLQPSMLVPEMMPYINGDAARGLLPVRQAVLWGHETHVCVLQTADDLLSRDIRVAVLVDGCASQQQLDHDVAIQEMSTWNNLTLATTISVLLQLSRGDPSVMGRVMKIIKSKSADPSRFPSVTADPETPKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HI94</accession>
    <name>A0A836HI94_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase M20 dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_06863</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M20B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000017">
        <property type="protein sequence ID" value="KAG5481788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064148.1">
        <property type="nucleotide sequence ID" value="XM_067208774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HI94"/>
    <dbReference type="SMR" id="A0A836HI94"/>
    <dbReference type="GeneID" id="92362708"/>
    <dbReference type="KEGG" id="loi:92362708"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045148">
        <property type="term" value="F:tripeptide aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03892">
        <property type="entry name" value="M20_peptT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010161">
        <property type="entry name" value="Peptidase_M20B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01882">
        <property type="entry name" value="peptidase-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003976">
        <property type="entry name" value="PRK05469.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009920">
        <property type="entry name" value="PRK13381.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42994">
        <property type="entry name" value="PEPTIDASE T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42994:SF1">
        <property type="entry name" value="PEPTIDASE T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037215">
        <property type="entry name" value="Peptidase_M20B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="9">
        <location>
            <begin position="217"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5481788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="423" mass="46863" checksum="3A5496619357EC89" modified="2021-09-29" version="1">MFLKPIEHRLEERFRRYSAITTQSDPRNIGKRIPSTPGQQALAELLAKELQAVGLQDIICDEYATVTAVKPGNVPGAPRIGFICHLDTFDSGLCPHVKAQKIHYTGGDVCLNAEKKIWMRAQEHPELRKYVGQDILFSDGTSVLGADDKAAITAVMEMVANLDSTREKHGDVVVCFVPDEEIGLIGAKHLDVKARFNVDFAYTLDCCELGEVVYECFNAANATIKFTGVSAHPMSAKGVMVNPLLMAVDFVSKFNRQETPECTELREGYWWFAKMEANTTQARLEVMVRDHDLAKYRARKAFLLDVVKEVQAKYPSGTVEIAMEDVYANISNALKDDFTAIDLLLEAMEKADVKPNVIPMRGGTDGAALSAHGLLTPNFFTGAHNFHSRFEFLPIPAFVKAFEVCCNIVLLGADKRKKTPSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HID1</accession>
    <name>A0A836HID1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Structure-specific endonuclease subunit SLX1 homolog</fullName>
            <ecNumber evidence="11">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LSCM4_04486</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">LSCM4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="11">Forms a heterodimer with a member of the SLX4 family.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the SLX1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="11"/>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062679.1">
        <property type="nucleotide sequence ID" value="XM_067206470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HID1"/>
    <dbReference type="SMR" id="A0A836HID1"/>
    <dbReference type="GeneID" id="92360404"/>
    <dbReference type="KEGG" id="loi:92360404"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033557">
        <property type="term" value="C:Slx1-Slx4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10455">
        <property type="entry name" value="GIY-YIG_SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="entry name" value="GIY-YIG endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03100">
        <property type="entry name" value="Endonuc_su_Slx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027520">
        <property type="entry name" value="Slx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050381">
        <property type="entry name" value="SLX1_endonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20208">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20208:SF13">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 11" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9 11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GIY-YIG" evidence="13">
        <location>
            <begin position="4"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="154"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="294"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="340"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="649"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="160"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="649"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="666"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG5477268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="698" mass="73818" checksum="957E1751BD26D2B3" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HID2</accession>
    <name>A0A836HID2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000017">
        <property type="protein sequence ID" value="KAG5481848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064208.1">
        <property type="nucleotide sequence ID" value="XM_067208834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HID2"/>
    <dbReference type="SMR" id="A0A836HID2"/>
    <dbReference type="GeneID" id="92362768"/>
    <dbReference type="KEGG" id="loi:92362768"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009691">
        <property type="term" value="P:cytokinin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005269">
        <property type="entry name" value="LOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00730">
        <property type="entry name" value="Rossman fold protein, TIGR00730 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31223">
        <property type="entry name" value="LOG FAMILY PROTEIN YJL055W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31223:SF70">
        <property type="entry name" value="LOG FAMILY PROTEIN YJL055W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102405">
        <property type="entry name" value="MCP/YpsA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="3"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5481848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="322" mass="35111" checksum="DC3ACA376B0ED0BD" modified="2021-09-29" version="1">MVVAAVFTIKLRDSEAEQQFLDAFAPLQQHVARNEPGTLTYELHQVFENGRPVSHQYLVMERYSSVRDFEETHLKSAPLQNLFKVVAGIAVEEQTLTVGSNVDSQPAIDSRPKVCSDNEIADPLLQKGVLVFAGARSGSKPAYTQEAKALAKYIIEEAKQPVVYGGGTVGVMGELAKEARALNGKIISIIPSSLSEREVSGSMIGDRIYTTATMSERKSIMFAHANTVVALPGGVGTFDELLEVITLFQLNAYRPKIGVVNADGFFEPFIALLQHLIAEGFLEENVFDFLVIKPTAIEVMEALKSFVPPPSPASTLTWASRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HJU3</accession>
    <name>A0A836HJU3_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000022">
        <property type="protein sequence ID" value="KAG5479261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063354.1">
        <property type="nucleotide sequence ID" value="XM_067203895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HJU3"/>
    <dbReference type="GeneID" id="92357829"/>
    <dbReference type="KEGG" id="loi:92357829"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5479261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="255" mass="28363" checksum="E9D8F6D3EDDA98D4" modified="2021-09-29" version="1">MGWFCAPVFEATVAYGTATEQEPVAATEREPKHQRQEREMNFPTSSTEAEQLNLLVAGARLDDTEAQDMARFLGSNKRHTYADGLLSCAVYTFSGLQHIHGQSNALTLLTMWTVGTTFLVDVAERKYLQEFLQGTLRAAEATSEAEQQVLRNQPPHNTTATSTPGEATAAPAMSAASCTLPSGMKKPSPHEMEKLSEQQRKVFLTQAVASWVWMLASFQQFKVHKRLKWCGYSSWMGLGCAGYYTTRHLYSLLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HK65</accession>
    <name>A0A836HK65_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleolar protein 56</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_06566</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000010">
        <property type="protein sequence ID" value="KAG5485610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065194.1">
        <property type="nucleotide sequence ID" value="XM_067208483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HK65"/>
    <dbReference type="SMR" id="A0A836HK65"/>
    <dbReference type="GeneID" id="92362417"/>
    <dbReference type="KEGG" id="loi:92362417"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000005">
        <property type="entry name" value="Nucleolar protein 5, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4070:FF:000004">
        <property type="entry name" value="Nucleolar protein 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012974">
        <property type="entry name" value="NOP58/56_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08156">
        <property type="entry name" value="NOP5NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Nop" evidence="7">
        <location>
            <begin position="302"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="445"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="449"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5485610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="474" mass="52600" checksum="4D14C6E614E0EDAB" modified="2021-09-29" version="1">MSKTLYTLYEAPTGYAIFKIRTTEEIGAEDVALQKELQDFSTFSPWVKLVSFAPFESPENALEDAVCISENLISTFLNNFLTAAFAKKVAKGEANWELGVQDPKLGSAIHDELNIPVLCNESVAEISRCIRLHAEKLLPEHNEGDVPRAQCGLGHAFSRNKVKFNVHRSDNMIIQASALMEHMDKGVNLLGMRVKEWYGWHFPELAKEVPEPLKYANVALLIGSRSSLEEASEEDVKSRLGDILEGDEALAARVYEKAVTSMGGDMAEVDWDCIRTFAKRVASLGQYRVALAQYLVDKMMLVAPNLTQLMGQTIGAKLISKAGSLTNLAKSPASTIQILGAEKALFRALKKKKGNTPKYGLIFHSSFIQRASKEHRGKISRYLANKAALACRIDCFMDAPPTVFGEKLREQVEARLNFFDTGNKPPSNKAAMAEALEQYQRILRKRDRKQAEEDAAEAPKAKKSRKVAVSSQSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HL05</accession>
    <name>A0A836HL05_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Csl4p homologue</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_04806</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000023">
        <property type="protein sequence ID" value="KAG5478573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063234.1">
        <property type="nucleotide sequence ID" value="XM_067206787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HL05"/>
    <dbReference type="GeneID" id="92360721"/>
    <dbReference type="KEGG" id="loi:92360721"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Csl4"/>
    </dbReference>
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        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12686">
        <property type="entry name" value="3'-5' EXORIBONUCLEASE CSL4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12686:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT CSL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
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    </dbReference>
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    <keyword evidence="2" id="KW-0271">Exosome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5478573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="29832" checksum="E2017402A925153D" modified="2021-09-29" version="1">MPVILHTGARVAPGDAIFTSPAAVASSPYALEGCAAEEAEVVPGEGCVVHYVERYVAPQAPSSLATSTVVERSIVATRHGVAQWDGRLVSVFALASCALASAGGTEHAAARGGSASVGTTVSSSRHSVLGPRPGDAVHLRITRLNRLFAFGEIIAVNWSWCSHRSLSAVAGGGSNSGVFKGVLRQEDIRPFKPTKDQLLPPPPSLAFGLGDVVLAEVISQSDVHQYQLSTIAEGFGVVESFITTMEGQYGGHEKVKLHHIPGRRDAMVIRSTGEVVPRWCPLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836HMA0_9TRYP</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_01807</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000022">
        <property type="protein sequence ID" value="KAG5479218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067203852.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92357786"/>
    <dbReference type="KEGG" id="loi:92357786"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5479218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1824" mass="188673" checksum="CD7F8624C5B32A68" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HPU8</accession>
    <name>A0A836HPU8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA ligase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_05979</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000011">
        <property type="protein sequence ID" value="KAG5485343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065080.1">
        <property type="nucleotide sequence ID" value="XM_067207906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HPU8"/>
    <dbReference type="GeneID" id="92361840"/>
    <dbReference type="KEGG" id="loi:92361840"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050326">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR47810">
        <property type="entry name" value="DNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47810:SF5">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
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    </dbReference>
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    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
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    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="465"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="691"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="469"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="709"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5485343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="765" mass="82878" checksum="596B637BE1ABA3CC" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HQE9</accession>
    <name>A0A836HQE9_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Euglenozoa</taxon>
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            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000016">
        <property type="protein sequence ID" value="KAG5482291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064297.1">
        <property type="nucleotide sequence ID" value="XM_067207483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HQE9"/>
    <dbReference type="SMR" id="A0A836HQE9"/>
    <dbReference type="GeneID" id="92361417"/>
    <dbReference type="KEGG" id="loi:92361417"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5482291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="208" mass="23317" checksum="3776F0858DDF8C3D" modified="2021-09-29" version="1">MSSTEADVSCARQRLPESVSERAGERLFAYAHVQRQSRKSAVEAQRSAETAGLFHPEVRSVAKGNSARHGPLYAAATPMCVQSVRPDEASANGSSPSAVPRCWRAFLSRAFDWERQRIARLQELRLQVVEGAVKECTFHPRLSPHLCACGACNYRHSAAASHAADFSVTREHEKQSSRRRRERWAAALAMFEAEMEELQDTLVRLRHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HQR7</accession>
    <name>A0A836HQR7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000019">
        <property type="protein sequence ID" value="KAG5480928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063929.1">
        <property type="nucleotide sequence ID" value="XM_067208417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HQR7"/>
    <dbReference type="SMR" id="A0A836HQR7"/>
    <dbReference type="GeneID" id="92362351"/>
    <dbReference type="KEGG" id="loi:92362351"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23090">
        <property type="entry name" value="mt-LAF7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5480928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="168" mass="19285" checksum="6608BC3EDA522AD0" modified="2021-09-29" version="1">MGGIKGGVGSFLLRRTAAKSIRQKHFTGPQFYKRKTFHFPAGHHQLHRRVAPALQTGSPTHQREHQRYAHLPGDARTRPSEDFTFSHSASPHNNGRCQERADKAMYAWAKRGSLQLYQMGGKRETFVCYRCGYPVRSALVAIKDDNWDYRMCYSCYTKTVDTGMERNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HR39</accession>
    <name>A0A836HR39_9TRYP</name>
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        <recommendedName>
            <fullName evidence="5">200 kDa antigen p200</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_07117</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000018">
        <property type="protein sequence ID" value="KAG5481405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064084.1">
        <property type="nucleotide sequence ID" value="XM_067209021.1"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A836HR39"/>
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    <dbReference type="KEGG" id="loi:92362955"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="141"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="845"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1044"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1134"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="259"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="508"/>
            <end position="811"/>
        </location>
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    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="946"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1099"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="853"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="871"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="884"/>
            <end position="898"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5481405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1158" mass="128860" checksum="91CD3B38E6AE6DEA" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HT21</accession>
    <name>A0A836HT21_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">diacylglycerol kinase (ATP)</fullName>
            <ecNumber evidence="3">2.7.1.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_05668</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic diacylglycerol kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.107" evidence="3"/>
    <dbReference type="EMBL" id="JAFHLR010000016">
        <property type="protein sequence ID" value="KAG5482410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064416.1">
        <property type="nucleotide sequence ID" value="XM_067207602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HT21"/>
    <dbReference type="GeneID" id="92361536"/>
    <dbReference type="KEGG" id="loi:92361536"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037607">
        <property type="entry name" value="DGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000756">
        <property type="entry name" value="Diacylglycerol_kin_accessory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255">
        <property type="entry name" value="DIACYLGLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255:SF54">
        <property type="entry name" value="DIACYLGLYCEROL KINASE THETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00609">
        <property type="entry name" value="DAGK_acc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00045">
        <property type="entry name" value="DAGKa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DAGKc" evidence="11">
        <location>
            <begin position="233"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="384"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="402"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5482410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="730" mass="78099" checksum="E98261C0F91BF95C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836K9C4</accession>
    <name>A0A836K9C4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Telomerase reverse transcriptase</fullName>
            <ecNumber evidence="2 13">2.7.7.49</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Telomerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LSCM4_00424</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Chromosome</location>
            <location evidence="13">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the reverse transcriptase family. Telomerase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="2 13"/>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058607.1">
        <property type="nucleotide sequence ID" value="XM_067202506.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92356440"/>
    <dbReference type="KEGG" id="loi:92356440"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000333">
        <property type="term" value="C:telomerase catalytic core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003720">
        <property type="term" value="F:telomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01648">
        <property type="entry name" value="TERT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021891">
        <property type="entry name" value="Telomerase_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003545">
        <property type="entry name" value="Telomerase_RT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12066">
        <property type="entry name" value="TELOMERASE REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12066:SF0">
        <property type="entry name" value="TELOMERASE REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12009">
        <property type="entry name" value="Telomerase_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01365">
        <property type="entry name" value="TELOMERASERT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00975">
        <property type="entry name" value="Telomerase_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 13" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="9 13" id="KW-0779">Telomere</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="15">
        <location>
            <begin position="817"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1345"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1367"/>
            <end position="1378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG5464976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1459" mass="159358" checksum="BD0C0332895FE932" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KBW6</accession>
    <name>A0A836KBW6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Defective in cullin neddylation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_00608</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058786.1">
        <property type="nucleotide sequence ID" value="XM_067202685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KBW6"/>
    <dbReference type="SMR" id="A0A836KBW6"/>
    <dbReference type="GeneID" id="92356619"/>
    <dbReference type="KEGG" id="loi:92356619"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032182">
        <property type="term" value="F:ubiquitin-like protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.200">
        <property type="entry name" value="Cullin, PONY binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014764">
        <property type="entry name" value="DCN-prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042460">
        <property type="entry name" value="DCN1-like_PONY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005176">
        <property type="entry name" value="PONY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281:SF31">
        <property type="entry name" value="DCN1-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281">
        <property type="entry name" value="RP42 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03556">
        <property type="entry name" value="Cullin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51229">
        <property type="entry name" value="DCUN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DCUN1" evidence="2">
        <location>
            <begin position="17"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU410713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5465155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="265" mass="30201" checksum="87A72A15F529BDC8" modified="2021-09-29" version="1">MGFLRVSKFNERPKANLAQEAFDYIYEQIPVPAEVRGERCLELGHFQSLAAATCLSLEDLSLYVLAFAVEESSKRLYKISEKHFVAWMAGLVSKLPRSAAPPAKENAYAPLFAAAHAAIIDLNETIRGNEEKRNMFYQFLYNWCLKGNDASDRVESARELWACFFSASPVSFTPEEGRHTFTAYVCFPRLNQWLDFISILNEAATETKAGRVAVEQSGVSLDTWTQLLLFAQIDHYDTYDKEDSWPVAMDDFVEYMRQIEASKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KDZ8</accession>
    <name>A0A836KDZ8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-editing substrate-binding complex 7 protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061200.1">
        <property type="nucleotide sequence ID" value="XM_067204163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KDZ8"/>
    <dbReference type="SMR" id="A0A836KDZ8"/>
    <dbReference type="GeneID" id="92358097"/>
    <dbReference type="KEGG" id="loi:92358097"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23679">
        <property type="entry name" value="RESC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058774">
        <property type="entry name" value="RESC7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26165">
        <property type="entry name" value="RESC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA-editing substrate-binding complex 7 protein" evidence="1">
        <location>
            <begin position="73"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5472804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="224" mass="24487" checksum="40BA505E51979223" modified="2021-09-29" version="1">MFTWLGRLPVCSSCRVLRGPSLARRTSVRAMTSSTRVFHALKNRRTGVTVAPPAPRGEAHTDAPRPPTLVASEAVSVGQRLYSLTQYYMQSRLNPGVGNLERERMSTEAWNLLQSISEEELEALPLRDVVEIVVAYNYFSCTWANGLNGPASAVKDGKSSGGPFTSSSQLSVDEQPLDYPIIERNDLGTGKGEAMLHTAMAAPLLAERDVPLKRASPLDEILEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KE44</accession>
    <name>A0A836KE44_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Succinyl-CoA:3-ketoacid-coenzyme A transferase</fullName>
            <ecNumber evidence="7">2.8.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_02560</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate</text>
            <dbReference type="Rhea" id="RHEA:24564"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35973"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.8.3.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Ketone metabolism; succinyl-CoA degradation; acetoacetyl-CoA from succinyl-CoA: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the 3-oxoacid CoA-transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.5" evidence="7"/>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060139.1">
        <property type="nucleotide sequence ID" value="XM_067204587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KE44"/>
    <dbReference type="SMR" id="A0A836KE44"/>
    <dbReference type="GeneID" id="92358521"/>
    <dbReference type="KEGG" id="loi:92358521"/>
    <dbReference type="UniPathway" id="UPA00929">
        <property type="reaction ID" value="UER00894"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008260">
        <property type="term" value="F:succinyl-CoA:3-oxo-acid CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046952">
        <property type="term" value="P:ketone body catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1080.10:FF:000001">
        <property type="entry name" value="Succinyl-coa:3-ketoacid-coenzyme a transferase subunit b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1080.10:FF:000002">
        <property type="entry name" value="Succinyl-CoA:3-ketoacid-coenzyme A transferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.10">
        <property type="entry name" value="Glutaconate Coenzyme A-transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012792">
        <property type="entry name" value="3-oxoacid_CoA-transf_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012791">
        <property type="entry name" value="3-oxoacid_CoA-transf_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014388">
        <property type="entry name" value="3-oxoacid_CoA-transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004164">
        <property type="entry name" value="CoA_transf_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004163">
        <property type="entry name" value="CoA_transf_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02429">
        <property type="entry name" value="pcaI_scoA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02428">
        <property type="entry name" value="pcaJ_scoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="KETOACID-COENZYME A TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707:SF23">
        <property type="entry name" value="SUCCINYL-COA:3-KETOACID-COENZYME A TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000858">
        <property type="entry name" value="SCOT-t"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01273">
        <property type="entry name" value="COA_TRANSF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01274">
        <property type="entry name" value="COA_TRANSF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="active site" description="5-glutamyl coenzyme A thioester intermediate" evidence="8">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000858-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5469162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="489" mass="52439" checksum="933FA86387928D55" modified="2021-09-29" version="1">MLRRNFFRLAGLNKVQSLEQAVADMTDGISVAVGGFGCSGVPDAVISAMCKKGVKDLTLYTDSAGIDGFGLARLIEAKQVRRMCCSFVGMNKIFKKRYLEGDVELEFVPQGTLAERMRAGGAGIPAFYTATAYGTQRQTGGQIIRYDKNGVPCIISEPKETRQFGNHWYVLETTIRPEYAIVKALKADKSGNLVFRGTARNFNIPAAQCGQRVIAEVEQVVENGDIHPDDVHLPGVYVHRVVPASYEVPIEKRTVSGSATEASTVNPADDRQRIARRAALEFADGMYVNLGIGIPTEAANYMPAGVTVTLHSENGLLGMGPFPTAEKVSADWINAGKQTISYMPGAACFDSATSFAMIRGGHINLTMLGALEVSSHGDLANWGIPGKLVNGPGGAMDLVASGSRVVVTMSHCNKSGDPKIVERCKLPVTGLHCVNRIITEKAVFDVIGKKLVLKEIAEGLTVDDINRCTAAHFEVDTVKPIAYAAPISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KF34</accession>
    <name>A0A836KF34_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="5">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_02997</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="5"/>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060568.1">
        <property type="nucleotide sequence ID" value="XM_067205016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KF34"/>
    <dbReference type="SMR" id="A0A836KF34"/>
    <dbReference type="GeneID" id="92358950"/>
    <dbReference type="KEGG" id="loi:92358950"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000005">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="6">
        <location>
            <begin position="112"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5470302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="308" mass="34969" checksum="14CAE450F71B3853" modified="2021-09-29" version="1">MSSEILDIDEHLATLNRCENIGEADVKRLCLKAKEIFTSEENVHKIPAPCTIVGDIHGQFYDLLELFRVGGEIPDTNYVFMGDFVDRGYHSVESFLLLLVLKIKYSRRVALVRGNHESRQITQVYGFYDECLRKYGSINVWRYCTDVFDLLPLASVVEGKIFCVHAGLSPSIQTVEQMRSIRRNCEVPHEGAMCDLLWSDPEDIDGWGLSPRGAGYLFGGDVVCQFNETNKLDLICRSHQLVMEGYKAMFNDTLVTVWSAPNYCYRCGNVASILELDEHLNKNFKIFEAAPAEAREAGQRNEVPAYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KFM3</accession>
    <name>A0A836KFM3_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_02404</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059987.1">
        <property type="nucleotide sequence ID" value="XM_067204435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KFM3"/>
    <dbReference type="SMR" id="A0A836KFM3"/>
    <dbReference type="GeneID" id="92358369"/>
    <dbReference type="KEGG" id="loi:92358369"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5469010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
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</entry>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
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                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG5471695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067205260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KI94"/>
    <dbReference type="GeneID" id="92359194"/>
    <dbReference type="KEGG" id="loi:92359194"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5471695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="50" mass="6036" checksum="62CEA50ECD7D2407" modified="2021-09-29" version="1">MRRPISCWRRGTLRWARRHPRRSSQRPRALLCTAALRRYLTGTRQPCRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KJ13</accession>
    <name>A0A836KJ13_9TRYP</name>
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        <recommendedName>
            <fullName evidence="4">LSM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
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            <taxon>Leishmania</taxon>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5474667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="163" mass="17065" checksum="6D9F2BD233D4FD69" modified="2021-09-29" version="1">MSANVNFSTGSRTTNGAPSAAAASVSAAPASKSNAPSSAKSKSHMILPYEVLFNLVGRRVTVLLTKGSQELEGTLESVDSDRGDMLLSEVVRYTWAPSRPLDEEETAAGAAGKRQGTSGDGAEEEGFCKCFGGGQRRELSRCSQAMVNSSFVALVTPTLFIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KJ74</accession>
    <name>A0A836KJ74_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_04041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
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        <lineage>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KJ74"/>
    <dbReference type="GeneID" id="92359965"/>
    <dbReference type="KEGG" id="loi:92359965"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1740.10">
        <property type="entry name" value="VC0467-like"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF143456">
        <property type="entry name" value="VC0467-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="560"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="590"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5474862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="605" mass="65667" checksum="3295518C9AF0971A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KJA3</accession>
    <name>A0A836KJA3_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="3" type="ORF">LSCM4_00802</name>
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    <organism evidence="3 4">
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059525.1">
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    </dbReference>
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    <dbReference type="GeneID" id="92356809"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
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    <feature type="chain" id="PRO_5032640538" evidence="2">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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    </feature>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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        <location>
            <begin position="254"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5467723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Flagellar attachment zone protein 1 conserved domain-containing protein</fullName>
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        <name evidence="3" type="ORF">LSCM4_05222</name>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476242.1"/>
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                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5477922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="483" mass="51613" checksum="D2C57706C1414498" modified="2021-09-29" version="1">MVRDISVLDMYHLIQRDPLHVDLSTYPTALMVRENVDCLTAHLLQFGAVESLNLAGMNASADVLDHLISSAETGGVAHLTHLNLRDTHLSPIHLANLLRVLKTRAPLLATLDISKNSLGDTAVESLTGSISATLQSLHIAANSLSAGAVTQLLQSLTDAKPTALRQLDLSDNHFDLKTSEALKALLTTTECRTTLKELRVAHCGLDEANSSCLAEGVHSSAVEVLDVSRNDCLLSFIFTVNEGHAVAFPASLRVLDLSGNVCKRGAIGGLVESLRGCSGRLEELYLRHTFQGDAALSAILCGASSMPALRVLDLAQCGLTYRSGKLLAQQLPMHSQLMVIRLSHNMLEVEGVMDMASGLERLCRLTTLELGSCHLSNCGAVAVVTSLLRSGAPVVQLDISDNSISNAGLCEVCTLLSRLTCPRLQRLIISNNPCTTGSQANLIEMLQGRQSACEVVADGTPLEVTRSNSSFEATHVSDSLRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KM25</accession>
    <name>A0A836KM25_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">IQ calmodulin-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5478027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062934.1">
        <property type="nucleotide sequence ID" value="XM_067207366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KM25"/>
    <dbReference type="GeneID" id="92361300"/>
    <dbReference type="KEGG" id="loi:92361300"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5478027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="873" mass="98441" checksum="3BBD769F09E7F946" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KM31</accession>
    <name>A0A836KM31_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_04177</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062103.1">
        <property type="nucleotide sequence ID" value="XM_067206166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KM31"/>
    <dbReference type="GeneID" id="92360100"/>
    <dbReference type="KEGG" id="loi:92360100"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5475595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="423" mass="44628" checksum="FF10F711B889438A" modified="2021-09-29" version="1">MQTSSAGDSPAPPATSGAPTDDGQSTRQLTANAASPEGVPATSFRAYMPFDRSTISSQQRRGGNLVLFVKPNENESEVASRVPTFASMQQLQQPQANGGGANGDVGSPSEEVNESVSGAGESALSVGASAFTGAIGSVGSVATGMARKPIFTAALVLIYFILLDIVLLSGNERLNRVLRRMRAVEDDALILLSASLVRQTAEAKRELRDAVAEHSGSEAKEAIEKVRGKVGVLERVCNRSVSRLHGMLMFPGSLEDLFFLIEAHAMYDDRLRDLAVHELRWATTVMAGHVVQAGGGGVEESQTQALGSGGAATQSSAMQGSKHPPTEGEGVDAASNPLRNVRLHRVREGVAPAMPAGDSYSQSRYTGARSTAALRQQADNAKKLASQLRGLQKVIEGLLALLRMKYVAFILICVMLSAVLRMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KN78</accession>
    <name>A0A836KN78_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000022">
        <property type="protein sequence ID" value="KAG5479302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063395.1">
        <property type="nucleotide sequence ID" value="XM_067203936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KN78"/>
    <dbReference type="GeneID" id="92357870"/>
    <dbReference type="KEGG" id="loi:92357870"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5479302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="476" mass="49393" checksum="C61F0E96900665DF" modified="2021-09-29" version="1">MEQPPEEEWCYGDLIAVRVHDFNEKVLGSTIPAAFAPTSEAGNPALCVSWIGEDPLEESVQPEKVPGESPAGDSRGEASIGGSKLPEPSASPVTPGSTMDGCEKPTAPACGVSAAAEPSPASNPPQPDFTPGGAAEGDRTVTFERQSAAGSKAATEATVDPSVLPTSLSAALADSPRSEGSNGEPSGAAQVPAPVAPVARKPRHSDCTPISISQAPKGVLHFQVITTLGTKVAVAEANVQSTLEADASESPHVQHYAVVITANASAESASMVYAVLEFSVVIGTTTIAKVASLAASASYAPMCTPLLVGSTCAFSTNTFYFSSKFLAGKGVYIVTNLLCVESFSDNSVSLEIALPDDLKQMHVLPEKKIILEKRGERAYFTCTWDVFSPYVDTANSKSGDSKRASPGFHVLIREGAENRAPVDIELAGELPPTKAEGVGPYMFFVNHAKITNISCSAGDMTVLDILPISLVTRAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KNF4</accession>
    <name>A0A836KNF4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Membrane-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_06399</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000019">
        <property type="protein sequence ID" value="KAG5480831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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                <person name="Bates M.D."/>
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                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="PANTHER" id="PTHR10434">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434:SF48">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="4">
        <location>
            <begin position="108"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5473603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="327" mass="37335" checksum="64B0338F617371E3" modified="2021-09-29" version="1">MTFLLWAVFAALYGCFLCLLRERKVPLMAMRVWYTLHMVLCVMISWFCCVVLILLGRAHLLGTATSQSLARCVCATTFGYWLRFNSPHIRVEHLPGSMSFSSMTEQHDLCVCHTSFFDTMLYLWCVPYSYIYKAKTFAKASLRNMPLFGTVMIACGHFLVYFSSEDVNSFSVDKDKQAAVAADVEDWVKEGKSLCFYPEGALNRTPEVLRDFRLGSFNTILKHKMPLHYLVVYGNHEVWPPSFKGLPGFPADIYTYVGKYDYNPDEEDALSLSTGLRKEIQRHLDDMVAKKKRLDKEAVIFRPASVLGGGEREGHYHREVHGSVLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KST0</accession>
    <name>A0A836KST0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetylglucosaminylphosphatidylinositol deacetylase</fullName>
            <ecNumber evidence="4">3.5.1.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_06695</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.89" evidence="4"/>
    <dbReference type="EMBL" id="JAFHLR010000009">
        <property type="protein sequence ID" value="KAG5485989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065320.1">
        <property type="nucleotide sequence ID" value="XM_067208609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KST0"/>
    <dbReference type="GeneID" id="92362543"/>
    <dbReference type="KEGG" id="loi:92362543"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000225">
        <property type="term" value="F:N-acetylglucosaminylphosphatidylinositol deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10320:FF:000002">
        <property type="entry name" value="Probable N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993:SF11">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5485989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="249" mass="27992" checksum="4B58FC55D0D79E80" modified="2021-09-29" version="1">MHSVTVVFFSVALSLLLLLWLRISNLAGTLVRSDVLLVFAHPDDEAMFFTPLLHSLRAQRVTVHFLCLSNGNYAGLGKEREKELYASGAFFGVQRRNIRVVDHADLQDGMHSVWSPLLIRREIESYMQKAGNISTIVTFDKYGVSGHPNHIAVHNGVRELKESMPPGLLHLQLRTRCLLCKYVGPLAVIPYALWSSTSVSRTSFVAVIPPASAWESMAAMQKHAGQLVWFRYLFVIFSSYTYVNEIEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KTL7</accession>
    <name>A0A836KTL7_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000016">
        <property type="protein sequence ID" value="KAG5482315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064321.1">
        <property type="nucleotide sequence ID" value="XM_067207507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KTL7"/>
    <dbReference type="GeneID" id="92361441"/>
    <dbReference type="KEGG" id="loi:92361441"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5482315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="393" mass="43921" checksum="461979D76DE50898" modified="2021-09-29" version="1">MHATVLCGAMRAVAPPIKASPLSQFLRDSAARGAVDGECNARAAHWPRSSLGPKGSSTESRTLLSSLPVGIFEGLNRHVWVDSRRSFCHLCQEPVGNTTSHTSDRDHTSMLFFLLLYTAYPRHDLLTEAARAPTAGENAVSVANDGNCASRLTSTLPSSPPPAHGRATGSPQSVHISKGRLDPLFTPKCVLGGAKRQFPSLFRYVTDCRATDRLHVVDDAVRRAELEALLLYLTHPPHQALSHVLQGQSPSGFWYSGERMWKAHITRIVAQLYPPMSAGMMTNFTQKCWGRTNGERLYDALCLHRIKAYHGWGPFESKERKAFFLRHLIWELLCVEVREEVSEEAKLLTSLALRRLAFEMVFLQSMDYMDRVQRVHELLGSPTLEELKNMHVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KU14</accession>
    <name>A0A836KU14_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000010">
        <property type="protein sequence ID" value="KAG5485647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065231.1">
        <property type="nucleotide sequence ID" value="XM_067208520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KU14"/>
    <dbReference type="GeneID" id="92362454"/>
    <dbReference type="KEGG" id="loi:92362454"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5485647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="267" mass="29544" checksum="C6DB4D0B993CB731" modified="2021-09-29" version="1">MPSLAKPSQKGRGKKRSGKKSAKIVPDPDAAYRQQLNEIVYIPKMVREKALDAYGTAADLAITACTVDTLLPQRGVYREGPISMIKVPNIFCSLGLCLTDDQFDQVTAMIAQKAAHISLGNGAGSQVEQIRLPGVYADREKLHALLVELLHTRVLAYDPQVLPCPHPRFPDRVSSVVYRSTESDIRSCFNTIWEASGRMVVVTPSGANTRCVAVEQLEELLRSAQTKVAATQALTQKELQDLYFFAKDVKHDVLKEDAFLSSFIHFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KUB9</accession>
    <name>A0A836KUB9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteophosphoglycan ppg4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_07786</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
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            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="4">
        <location>
            <begin position="9"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00070796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5488031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="332" mass="34722" checksum="4E8EE8C9FB3050A6" modified="2021-09-29" version="1">MEVVATAHGGPEVLALRPSTHTPDAMQLEEGQVLVRNAYAGVNFIDTYFMRGLYKKPTMPYVVGEEGAGSVVKVGPGVPEMLLGKRVAYFGGVGCSGSYAAFTVIQASELREVPDGVTEAEAAALMCQGLTAHYLVDSSYPCGPASTVVVHAAAGGTGLLVCQMAKLRGARVIGVCGGAEKAALAASVGGADVVIDYTATPDWAPLVRAAAPQGVDAVYDGVGKATFAGSLSVLRPRGYMITFGNASGAVAPVSPLDLSRAGSVYLQRPTLGDFMRTPDERERRASDLFRWVASKQLQLTIGHEYPLREAAQALTDLQARKTTGKLLLNCVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836L1D4</accession>
    <name>A0A836L1D4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_05999</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000011">
        <property type="protein sequence ID" value="KAG5485363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065100.1">
        <property type="nucleotide sequence ID" value="XM_067207926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836L1D4"/>
    <dbReference type="GeneID" id="92361860"/>
    <dbReference type="KEGG" id="loi:92361860"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="244"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="141"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="397"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="399"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="456"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="522"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="550"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="593"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5485363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="602" mass="63694" checksum="B3140DE35FE03BE2" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836L302</accession>
    <name>A0A836L302_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ras-related protein rab-14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_06314</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000007">
        <property type="protein sequence ID" value="KAG5486848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065642.1">
        <property type="nucleotide sequence ID" value="XM_067208237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836L302"/>
    <dbReference type="SMR" id="A0A836L302"/>
    <dbReference type="GeneID" id="92362171"/>
    <dbReference type="KEGG" id="loi:92362171"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001193">
        <property type="entry name" value="Rab family, other"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5486848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="24358" checksum="D52C2887F6A9DE12" modified="2021-09-29" version="1">MSHKYIFKYIIIGDMSVGKSCLMHLFTEQRYRKDLPHTIGVDFGTTVVDINGELVKLQMWDTAGQERFRSVTRGYYRGAAGALLVYDISRRSTYAHIGTWLTDARANTGPETVFILVGNKSDLEEEREVSYEEAAQFAAEHNLLFVECSSLNGKNVEEVFLSTARRIHEKVKSGVMSPVDPESGVQLHAAAIPTSTASSGQAGGPVNLSTGSGGGVAAASESSCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836L402</accession>
    <name>A0A836L402_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_07456</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000004">
        <property type="protein sequence ID" value="KAG5487778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065975.1">
        <property type="nucleotide sequence ID" value="XM_067209343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836L402"/>
    <dbReference type="GeneID" id="92363277"/>
    <dbReference type="KEGG" id="loi:92363277"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053125">
        <property type="entry name" value="RNA-bd_mRNA_stabilization_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37035:SF4">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37035">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5487778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="444" mass="47582" checksum="3F7F751CE56D0367" modified="2021-09-29" version="1">MFASYPVQQPMGALPMTVVYPRSYLPHGSVSCPVSSYRSMLNGYSVAPMMMSAGSAPCPVNAYFGHSATPVYFFMDPANSAARIAVAADATSACTTPTAKLAHSGSGNSLSTQSCCSGGDTPSLLSHSAASSSLKQRPQHDVNVWGFALVDQLHPLLQRIPVPPSCVREVTVGISLYDNDVTSSSTRPCRSSVCLLHAQGLGCAEGARCRCFHVCHPYLMQCRATSESLCCALHNCYYSQEMLSANCAPHVSGRCYALSLDDASKFPQNGDEPYLIDLSVLNLSLTVGLEMLPCVNGLYVISWKKHVCHLNMDGRCKWTKDCGHIHVCHQLAKFLQDAETLSIVKALQEKTASKSSAELYRDIILSENTLRYVRSPAAVSLVAALLEAGDVEALKALARAKCALLSCQIEALQKLGIALSCSDSGRSVTVSPKIYGLLTPTVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FLP0</accession>
    <name>A0A836FLP0_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_00400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058583.1">
        <property type="nucleotide sequence ID" value="XM_067202482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836FLP0"/>
    <dbReference type="GeneID" id="92356416"/>
    <dbReference type="KEGG" id="loi:92356416"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5464952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="194" mass="21641" checksum="30347249832ABCC1" modified="2021-09-29" version="1">MLRFYPALRSASVQRKPHLFHIDLKSKHTPGHLYFADRAVKSTAEEPCFVCLDNAMACQTADSNAAVVLRSCMTKDRALFEYGRVRFQGMNAALVFRHNRLIFQGVGDLSVQTLQMSLHYNDIFALLGGISPHENITEWARTVEKAVTEGDVEYVAEEMLLQLRCATEGCTSIVAKISKFSTGLPEPPSFSHST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FZJ3</accession>
    <name>A0A836FZJ3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_00232</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058422.1">
        <property type="nucleotide sequence ID" value="XM_067202321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836FZJ3"/>
    <dbReference type="GeneID" id="92356255"/>
    <dbReference type="KEGG" id="loi:92356255"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032929151" description="BRCT domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="233"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5464791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="375" mass="40221" checksum="3F57CC877346C920" modified="2021-09-29" version="1">MFHGHAFLVSLTASPLTVAELTHNGARMVYDLDGETPVTCVIIASDNQLGTPARCSRGWATPNAMPASLEDHVRARRITVVYEHWVHQCVRKRRLLLPCRDYPDAIAYDPHLFASVHFTTTQLPMQLKANIIALMQFYGATYHNHLLNITNLLVHSHVHLSPAVARSEGPGTGAPLPLDADRRDAVTLASIKDGEAANAGPGERLTTGTSGDNPTEAAKPPLTKLAVARQLGIPCVTPQWVQLCLNAGELLPVQPALASPPLARALLHPSTESGATMQTDAPASSVTDADELCCCEEELDRWIGEALMSTSHSAHPDRGSTPTDACAAHLHVPSSCMVPRKKEAASEAREAPKGAAQLSPSRASASKARKRRRVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FZZ9</accession>
    <name>A0A836FZZ9_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_00543</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058722.1">
        <property type="nucleotide sequence ID" value="XM_067202621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836FZZ9"/>
    <dbReference type="GeneID" id="92356555"/>
    <dbReference type="KEGG" id="loi:92356555"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5465091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="392" mass="43798" checksum="DD8F55AE748AD68E" modified="2021-09-29" version="1">MTFNLEKLNRGLTRLASVRQYPTAKKQYVAKQTKGRVFRVGVLHKKELTETALLRNRRGFINAQLNTVAHAPSMYHWLFHRCGIPFAETQALVRSGGLKVNELIVSSFSDLESQLSWETFQQLDIQICSSLPALQSSSSTGTGERDISRPAEGTWVPALKRALHRTYTFIYLHSGVSISSEESEPRSFVHRMAPIMGADPRALLGLNVLRPMGFLNGMKGIGIASNDVSMVRYWNNESLGSFGVYDVRFPRGTPLEVVRQSAKDIEATLEEKVQSQLSSDVGVSCSCVCCPPPPPPRDTVANYLFSALPLLTEERLLVTTPLLPYRAARRLQRNGAVISLVRNGPFVLRSSLAQEKLRPCSATDLALLFTFERRLKTNRMVLSLREFDSERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G3U9</accession>
    <name>A0A836G3U9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_03785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061718.1">
        <property type="nucleotide sequence ID" value="XM_067205781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G3U9"/>
    <dbReference type="GeneID" id="92359715"/>
    <dbReference type="KEGG" id="loi:92359715"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5474612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="228" mass="23906" checksum="71BA4D98DA66DE0D" modified="2021-09-29" version="1">MGQPIGETAPFPPRTVTSFKPEIIYQNKTSGEMVRAINVSINAVNATLRNLSSRLGSAAATLKPTTSAPPFPMAASSGSSVGTGNNDVMTTTTTAAPLRDGLNTMDTTSLSEQVSQLSMVHLLAWFLLFASMTLLTVVLLNCCLRSQQDAADAAENDDDDEELRGKLTVASSVFSQGTHIEGPSSATSSSSRLLLSRGNLARQQFLESRKTGSAVKSYGGTASTSPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G4E9</accession>
    <name>A0A836G4E9_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_01201</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I NDUFA5 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058954.1">
        <property type="nucleotide sequence ID" value="XM_067203263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G4E9"/>
    <dbReference type="SMR" id="A0A836G4E9"/>
    <dbReference type="GeneID" id="92357197"/>
    <dbReference type="KEGG" id="loi:92357197"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006806">
        <property type="entry name" value="NDUFA5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12653:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12653">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 13 KD-B SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5466064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="263" mass="30755" checksum="ADA585BEFA54A406" modified="2021-09-29" version="1">MLPSRFLLGAFCSTTPLRTISDEYIPRAFPVKSTTGLAGVAVEPLWKPKLLAAASELQAFLHTSDIPPESTYYNVTMTLVKRINYGIKECQDDWCTLEKKFFWGWPVEYILQVTWRELETAQKWNEWRFWELDPEQVKRVAREDQGVGKEGLGYNTPWEQVVREDFDKRKKALTQEEMAELKRMDTERMARETAAYKERKDRIRDDLEKARGEMLKKFLNKRYAVDKDLMRMQPGRSYSGKSADDLIDELRASVKQTPSPPDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G5P9</accession>
    <name>A0A836G5P9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MEX67-like NTF2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_04245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062170.1">
        <property type="nucleotide sequence ID" value="XM_067206233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G5P9"/>
    <dbReference type="GeneID" id="92360167"/>
    <dbReference type="KEGG" id="loi:92360167"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057127">
        <property type="entry name" value="NTF2_MEX67"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030217">
        <property type="entry name" value="NXF_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662:SF22">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23056">
        <property type="entry name" value="NTF2_MEX67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MEX67-like NTF2-like" evidence="2">
        <location>
            <begin position="270"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5475662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="556" mass="60599" checksum="596C0C0A527C7EF7" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G7J0</accession>
    <name>A0A836G7J0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tuzin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_01010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059726.1">
        <property type="nucleotide sequence ID" value="XM_067203076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G7J0"/>
    <dbReference type="GeneID" id="92357010"/>
    <dbReference type="KEGG" id="loi:92357010"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34157">
        <property type="entry name" value="TUZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34157:SF2">
        <property type="entry name" value="TUZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="537"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5467924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="556" mass="60027" checksum="10CB208B04AFB8D3" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G8A8</accession>
    <name>A0A836G8A8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MORN repeat-containing protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_02701</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Assembles a suppression complex (suppresome) by tethering SIRT1 and MDM2 to regulate composite modifications of p53/TP53. Confers both deacetylation-mediated functional inactivation, by SIRT1, and ubiquitination-dependent degradation, by MDM2, of p53/TP53, promoting a proliferative and cell survival behaviors. May play a role in the regulation of spermatogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle</location>
            <location evidence="1">Acrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060277.1">
        <property type="nucleotide sequence ID" value="XM_067204725.1"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A836G8A8"/>
    <dbReference type="GeneID" id="92358659"/>
    <dbReference type="KEGG" id="loi:92358659"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:acrosomal vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
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    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kinesin_motor_dom"/>
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    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="MORN"/>
    </dbReference>
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        <property type="entry name" value="MORN3"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="MORN REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46511:SF1">
        <property type="entry name" value="MORN REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kinesin"/>
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    </dbReference>
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        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MORN"/>
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    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
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    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
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            <begin position="99"/>
            <end position="106"/>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:30616"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039854"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00045851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5470011.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="719" mass="80396" checksum="8F874397FDD83E88" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GAM0</accession>
    <name>A0A836GAM0_9TRYP</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">LSCM4_04654</name>
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    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG5478422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063083.1">
        <property type="nucleotide sequence ID" value="XM_067206636.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92360570"/>
    <dbReference type="KEGG" id="loi:92360570"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="59"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="692"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="756"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1030"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1195"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1349"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1431"/>
            <end position="1475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="73"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1207"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1218"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1436"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1457"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1957"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5478422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GD01</accession>
    <name>A0A836GD01_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_02018</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
            <location evidence="1 6">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061092.1">
        <property type="nucleotide sequence ID" value="XM_067204055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GD01"/>
    <dbReference type="GeneID" id="92357989"/>
    <dbReference type="KEGG" id="loi:92357989"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF27">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="8">
        <location>
            <begin position="335"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="743"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="748"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5472696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="776" mass="84411" checksum="1F420D106C7DBBD6" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GDE0</accession>
    <name>A0A836GDE0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">3-hydroxy-3-methylglutaryl coenzyme A reductase</fullName>
            <shortName evidence="6">HMG-CoA reductase</shortName>
            <ecNumber evidence="6">1.1.1.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_02246</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(R)-mevalonate + 2 NADP(+) + CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15989"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.34"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the HMG-CoA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.34" evidence="6"/>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061317.1">
        <property type="nucleotide sequence ID" value="XM_067204280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GDE0"/>
    <dbReference type="SMR" id="A0A836GDE0"/>
    <dbReference type="GeneID" id="92358214"/>
    <dbReference type="KEGG" id="loi:92358214"/>
    <dbReference type="UniPathway" id="UPA00058">
        <property type="reaction ID" value="UER00103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004420">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015936">
        <property type="term" value="P:coenzyme A metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00643">
        <property type="entry name" value="HMG-CoA_reductase_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3270.10:FF:000003">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.420:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.770.10:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.770.10">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl-coenzyme A Reductase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3270.10">
        <property type="entry name" value="HMGR, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.420">
        <property type="entry name" value="Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002202">
        <property type="entry name" value="HMG_CoA_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023074">
        <property type="entry name" value="HMG_CoA_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023076">
        <property type="entry name" value="HMG_CoA_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004554">
        <property type="entry name" value="HMG_CoA_Rdtase_eu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023282">
        <property type="entry name" value="HMG_CoA_Rdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009023">
        <property type="entry name" value="HMG_CoA_Rdtase_NAD(P)-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009029">
        <property type="entry name" value="HMG_CoA_Rdtase_sub-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00533">
        <property type="entry name" value="HMG_CoA_R_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572:SF24">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00368">
        <property type="entry name" value="HMG-CoA_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00071">
        <property type="entry name" value="HMGCOARDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55035">
        <property type="entry name" value="NAD-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56542">
        <property type="entry name" value="Substrate-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00066">
        <property type="entry name" value="HMG_COA_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00318">
        <property type="entry name" value="HMG_COA_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50065">
        <property type="entry name" value="HMG_COA_REDUCTASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0521">NADP</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5472921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="433" mass="45816" checksum="B7AE0C56386B9B39" modified="2021-09-29" version="1">MRRSLLLACSAAKGGSWASMSDAEIMKQVENKKIAFYGLEQALAPDYDRAIAIRREIVKKMCPSSASTHPLERVPYKNYDWSSVVGQSCENILGYVPVPVGLAGPLLLDGREVGLPMATTEGALIASTHRGARAINQSGGCRTVVLKEGMTRAPVVEVNSFDEAIAVVKFCEERFDVLKEAFESTTRFGKLLSIKCAMVGRQVHMRFTAFTGDAMGMNMITKGCDKSLQVLHHHIPSVRVLALSGNFCTDKKPSAVNWVEGRGKSVVAEAVIKRDVVEGVLKCTVDSVVSLNVTKNLRGSALAGSIGGFNAHAANVVAALYIATGQDPAQVVESSMCMTTVDKAGEDLIISITMPSIEVGSVGGGTGLSSQRAMLELMGCAGANKEDPGANSRQIARVVAGAVICGELSLLAGLAAGHLLSAHMKLNRKPPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GGC8</accession>
    <name>A0A836GGC8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TLDc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_00201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058391.1">
        <property type="nucleotide sequence ID" value="XM_067202290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GGC8"/>
    <dbReference type="GeneID" id="92356224"/>
    <dbReference type="KEGG" id="loi:92356224"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354">
        <property type="entry name" value="NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="1">
        <location>
            <begin position="83"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5464760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="352" mass="38882" checksum="4B1345FE241A602E" modified="2021-09-29" version="1">MQVMSFHVIFFGSAALAKLKPFFCPSIRVDLAPMGQSFNAPSEDGVGKCDEHVPEKEEKVYHLPPALPSPEIVGVDDADKSILVLTPKLAARLADALPPSCKCGTFSEVTKWYLLYSSYLNGKSFQRLVQHITSRGPTIIVIKVKDSPRVLGAFCESDWLTVAERERNAKSAAAASARARREGQKQCATTAPTNQSNAFFGSMNCFVFRANAHGTDDVSADGEIYRSHSSMNSNFMYLFDTHPLEEKIGIGMGGQPGYYGWFIDRWLENGASHGVRCSTFKNPRLSPTESWLVESVEVYAVKKSIVEQLLRTGNESGRGVSCVDDNTDSKASQMLLELNGTHEFSRWDRTEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GJC7</accession>
    <name>A0A836GJC7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">MGT1 magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LSCM4_07302</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000015">
        <property type="protein sequence ID" value="KAG5483087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064583.1">
        <property type="nucleotide sequence ID" value="XM_067209200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GJC7"/>
    <dbReference type="SMR" id="A0A836GJC7"/>
    <dbReference type="GeneID" id="92363134"/>
    <dbReference type="KEGG" id="loi:92363134"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000001">
        <property type="entry name" value="Magnesium transport protein CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494:SF1">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="771"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="804"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="121"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="275"/>
            <end position="337"/>
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    </feature>
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        <location>
            <begin position="1"/>
            <end position="13"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="43"/>
            <end position="59"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="122"/>
            <end position="131"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="132"/>
            <end position="148"/>
        </location>
    </feature>
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            <begin position="174"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
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            <begin position="292"/>
            <end position="305"/>
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    </feature>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG5483087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="828" mass="92344" checksum="D8B9B2DA2601BF09" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GKR3</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">LSCM4_04156</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
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            <taxon>Eukaryota</taxon>
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            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062082.1">
        <property type="nucleotide sequence ID" value="XM_067206145.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="92360079"/>
    <dbReference type="KEGG" id="loi:92360079"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5475574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="867" mass="95509" checksum="5D3B41B7569440E1" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GLV8</accession>
    <name>A0A836GLV8_9TRYP</name>
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        <recommendedName>
            <fullName evidence="2">Splicing factor Cactin C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_03996</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061925.1">
        <property type="nucleotide sequence ID" value="XM_067205988.1"/>
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    <dbReference type="KEGG" id="loi:92359922"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="POLYGLUTAMINE BINDING PROTEIN 1/MARVEL MEMBRANE-ASSOCIATING DOMAIN CONTAINING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21737:SF4">
        <property type="entry name" value="SPLICING FACTOR CACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09732">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="542"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="306"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="385"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5474819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="691" mass="76839" checksum="422CD67A6E9F282F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GMA5</accession>
    <name>A0A836GMA5_9TRYP</name>
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        <recommendedName>
            <fullName evidence="3">T-complex protein 1 subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">CCT-alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LSCM4_03022</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060593.1">
        <property type="nucleotide sequence ID" value="XM_067205041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GMA5"/>
    <dbReference type="SMR" id="A0A836GMA5"/>
    <dbReference type="GeneID" id="92358975"/>
    <dbReference type="KEGG" id="loi:92358975"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03335">
        <property type="entry name" value="TCP1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000009">
        <property type="entry name" value="T-complex protein 1 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000070">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012715">
        <property type="entry name" value="Chap_CCT_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0346">Stress response</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG5470327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="546" mass="59205" checksum="A428F0646EDD7B63" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GMQ7</accession>
    <name>A0A836GMQ7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_07612</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000012">
        <property type="protein sequence ID" value="KAG5484842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064954.1">
        <property type="nucleotide sequence ID" value="XM_067209494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GMQ7"/>
    <dbReference type="SMR" id="A0A836GMQ7"/>
    <dbReference type="GeneID" id="92363428"/>
    <dbReference type="KEGG" id="loi:92363428"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000018">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000033">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000304">
        <property type="entry name" value="Proteasome regulatory ATPase subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="10">
        <location>
            <begin position="190"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5484842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="411" mass="45807" checksum="26F7F7A563878676" modified="2021-09-29" version="1">MATSGVVSASAARASALASKKAERDAHANRSLFEEYEQLSKDIKNIQLKTMICRTETHQLMKEESAAKQEVKRIQAVPLVLGNFVEAVDSVRGIVSGTSGSQYFVRILSTLNKELLKPNVSVGLHKSSNACVQLLPSETDATITLLNSSDRPDVAYSDVGGLDMQKQEIREAVELPLTHAGLYEQIGIDPPRGVLLYGPPGTGKTMLVKAVARHTKASFIRVVGSEFVQKFLGEGPRKVRDVFRLARENAPSIIFIDEVDSIATKRFDAQTGADREVQRVLVELLTQMDGFDQTTNVKVIMATNRWDTLDPALLRPGRLDRKIEFPYPDRRQKRLVFQVCTSKMNLSPEVDLEDYVTRPEKLSGADIQSICQEAGMLAVRKNRYVILPRDIENAYRTVIKKTGDETYDFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GP08</accession>
    <name>A0A836GP08_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_02491</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060072.1">
        <property type="nucleotide sequence ID" value="XM_067204520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GP08"/>
    <dbReference type="SMR" id="A0A836GP08"/>
    <dbReference type="GeneID" id="92358454"/>
    <dbReference type="KEGG" id="loi:92358454"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14003">
        <property type="entry name" value="STKc_AMPK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000491">
        <property type="entry name" value="Protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001513">
        <property type="entry name" value="Protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="35"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="344"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="382"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="438"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5469095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="643" mass="72485" checksum="B8D4040C5B31EF6D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GPR2</accession>
    <name>A0A836GPR2_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_00782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059505.1">
        <property type="nucleotide sequence ID" value="XM_067202855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GPR2"/>
    <dbReference type="SMR" id="A0A836GPR2"/>
    <dbReference type="GeneID" id="92356789"/>
    <dbReference type="KEGG" id="loi:92356789"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5467703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="416" mass="46158" checksum="17766FD79A528D94" modified="2021-09-29" version="1">MFSDSSGDGPRTSWKTPVKPRARDGLTTGSTGIMPNEYHSGLADAKPQPSLQQRCSMRAGLSSAPRHAQGRRHLDPHHFTSLTDDTKRAEGRLGRAHVASSEQQKRADAYYATKQPTVAQPPGAECNLYLTSYYYTPLSKRDSPSPPIRQPTGFRADAQSTSFQLSEARLRKIKREHPLYEEEVERALQQHHGDYSIVSTEQKISRRVAVEEYAKDSDARVAHIEASTKYHGTPDLGSPASAIERSVPYALSEACPPRADTQLSCTSHVRMYPGRGRSSSPQATPVKPCDRHLHDGPAPYDSVAVSGSAYPSPPVVGERCNIYAKPTLVRVDERRHLNCMEDTDSLAMKRARARSGASVSKERPDFIFGPGPPPQVHQPSLRHRTEARWKAQERSAQERRTGRALCPQSYKSTSLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GPR9</accession>
    <name>A0A836GPR9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zinc finger LSD1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_03229</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">LSCM4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060794.1">
        <property type="nucleotide sequence ID" value="XM_067205242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GPR9"/>
    <dbReference type="GeneID" id="92359176"/>
    <dbReference type="KEGG" id="loi:92359176"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040319">
        <property type="entry name" value="LSD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005735">
        <property type="entry name" value="Znf_LSD1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01053">
        <property type="entry name" value="LSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31747">
        <property type="entry name" value="PROTEIN LSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31747:SF3">
        <property type="entry name" value="PROTEIN LSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06943">
        <property type="entry name" value="zf-LSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zinc finger LSD1-type" evidence="3">
        <location>
            <begin position="13"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5471677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="126" mass="13373" checksum="0786C74FD66F86D5" modified="2021-09-29" version="1">MPHAPQSTGQITCSQCHVTLAYPIGAPSVRCPMCAAVTPVQQFSVTCVCCRCILILPQNTSLAMCPRCRTVMSIPASIREGHSGPQAPPKQCVYIERPPTVNSAGVKVAQLAVGTKLDDDNVPAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GQW7</accession>
    <name>A0A836GQW7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Checkpoint protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_04641</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the HUS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000023">
        <property type="protein sequence ID" value="KAG5478409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063070.1">
        <property type="nucleotide sequence ID" value="XM_067206623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GQW7"/>
    <dbReference type="SMR" id="A0A836GQW7"/>
    <dbReference type="GeneID" id="92360557"/>
    <dbReference type="KEGG" id="loi:92360557"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044778">
        <property type="term" value="P:meiotic DNA integrity checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016580">
        <property type="entry name" value="HUS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007150">
        <property type="entry name" value="HUS1/Mec3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12900:SF0">
        <property type="entry name" value="CHECKPOINT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12900">
        <property type="entry name" value="MITOTIC AND DNA DAMAGE CHECKPOINT PROTEIN HUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04005">
        <property type="entry name" value="Hus1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011312">
        <property type="entry name" value="Cell_cycle_HUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="193"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR011312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5478409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="330" mass="36719" checksum="81DFDA88E17B6563" modified="2021-09-29" version="1">MRFKATLKDAKGLLGVLQVCRSIQRDCIVRLQSERVRFFSNASAADGVQVWMRCKSSFLFSEMICDSGYEEHSITCEVLDLAQLIHIVKQAEARERSQQGAASHVQMRLARRGRCPLWRVAMQGLSGQPDVTFDVPLRILGDREIKSLLPPPLQRQHLQILVPDMLELTTFIDKLKNTAADSVTFSARVLTPPATRRGTEDGMAEGDEGGAGVRHGVKRPRGKDTIPLASLLIYAEHFMARFSLKYDAVELVQQPEREDDGGVDDDGGTVDDVRVATVMVETRKFARFFSAVKELDPVKISMYLMDHRALVLSVFAIGNTAMVAYIPAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GS90</accession>
    <name>A0A836GS90_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5478014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062921.1">
        <property type="nucleotide sequence ID" value="XM_067207353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GS90"/>
    <dbReference type="GeneID" id="92361287"/>
    <dbReference type="KEGG" id="loi:92361287"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="508"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5478014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="532" mass="55835" checksum="E9FA9E0FAB6B147B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GS93</accession>
    <name>A0A836GS93_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Acireductone dioxygenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Acireductone dioxygenase (Fe(2+)-requiring)</fullName>
            <shortName evidence="11">ARD'</shortName>
            <shortName evidence="11">Fe-ARD</shortName>
            <ecNumber evidence="11">1.13.11.54</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Acireductone dioxygenase (Ni(2+)-requiring)</fullName>
            <shortName evidence="11">ARD</shortName>
            <shortName evidence="11">Ni-ARD</shortName>
            <ecNumber evidence="11">1.13.11.53</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LSCM4_06172</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">LSCM4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14161"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17245"/>
            <dbReference type="ChEBI" id="CHEBI:49016"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.53"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24504"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16723"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
        <text evidence="11">Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the acireductone dioxygenase (ARD) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.54" evidence="11"/>
    <dbReference type="EC" id="1.13.11.53" evidence="11"/>
    <dbReference type="EMBL" id="JAFHLR010000020">
        <property type="protein sequence ID" value="KAG5480406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063737.1">
        <property type="nucleotide sequence ID" value="XM_067208097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GS93"/>
    <dbReference type="SMR" id="A0A836GS93"/>
    <dbReference type="GeneID" id="92362031"/>
    <dbReference type="KEGG" id="loi:92362031"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00878"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010308">
        <property type="term" value="F:acireductone dioxygenase (Ni2+-requiring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010309">
        <property type="term" value="F:acireductone dioxygenase [iron(II)-requiring] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02232">
        <property type="entry name" value="cupin_ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000099">
        <property type="entry name" value="1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03154">
        <property type="entry name" value="Salvage_MtnD_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004313">
        <property type="entry name" value="ARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027496">
        <property type="entry name" value="ARD_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010357">
        <property type="entry name" value="TXNDC17_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418:SF0">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03079">
        <property type="entry name" value="ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06110">
        <property type="entry name" value="TXD17-like_Trx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8 11" id="KW-0408">Iron</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0486">Methionine biosynthesis</keyword>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="MecKel-Gruber Syndrome (MKS) homolog"/>
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    <dbReference type="Gene3D" id="3.10.620.30">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C2_dom"/>
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        <property type="entry name" value="C2_domain_sf"/>
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        <property type="entry name" value="CEPT76/DRC7_peptidase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052434">
        <property type="entry name" value="Tectonic-like_complex_comp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20837">
        <property type="entry name" value="CENTROSOMAL PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20837:SF0">
        <property type="entry name" value="COILED-COIL AND C2 DOMAIN-CONTAINING PROTEIN 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24656">
        <property type="entry name" value="CEPT76_peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C2"/>
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    </dbReference>
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        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
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        <location>
            <begin position="1593"/>
            <end position="1736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="430"/>
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        <location>
            <begin position="857"/>
            <end position="918"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="951"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1273"/>
            <end position="1301"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1313"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1804"/>
            <end position="1825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2184"/>
            <end position="2238"/>
        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="956"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <begin position="1320"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1804"/>
            <end position="1816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="2196"/>
            <end position="2209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2210"/>
            <end position="2229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5488292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="2315" mass="250486" checksum="0ABF6024B7CF9A64" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GVE4</accession>
    <name>A0A836GVE4_9TRYP</name>
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        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL6 alpha-beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_05837</name>
    </gene>
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        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063540.1">
        <property type="nucleotide sequence ID" value="XM_067207767.1"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A836GVE4"/>
    <dbReference type="GeneID" id="92361701"/>
    <dbReference type="KEGG" id="loi:92361701"/>
    <dbReference type="Proteomes" id="UP000674143">
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ribosomal_uL6-like"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ribosomal_uL6_CS2"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
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        <location>
            <begin position="12"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="4">
        <location>
            <begin position="98"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5479829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="190" mass="21446" checksum="E9E5675E5D853F85" modified="2021-09-29" version="1">MVKVKSLSTLSIPEGVTVDVRGRKVTVTGKRGTLTKDMSHLQLDFRVDKKNRTLTAIRWFGSKIPIACLNTTKAHVQNMITGVTKGYRYKVRCAYAHFPINVSVDGQQIEVRNFLGEKRVRRQLVPSTVKVSQTDPSKVKDEIVFEGNDLEQVSREAAVLHQMCLVKNKDIRKFLDGIYVQTKTNVEAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GVR7</accession>
    <name>A0A836GVR7_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061181.1">
        <property type="nucleotide sequence ID" value="XM_067204144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GVR7"/>
    <dbReference type="GeneID" id="92358078"/>
    <dbReference type="KEGG" id="loi:92358078"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="526"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5472785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1000" mass="105183" checksum="E833D6189850C9C0" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GW62</accession>
    <name>A0A836GW62_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_00738</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058914.1">
        <property type="nucleotide sequence ID" value="XM_067202813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GW62"/>
    <dbReference type="SMR" id="A0A836GW62"/>
    <dbReference type="GeneID" id="92356747"/>
    <dbReference type="KEGG" id="loi:92356747"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    <dbReference type="GO" id="GO:0006355">
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="58"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5465283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="286" mass="32776" checksum="5B3EB15FF38796A2" modified="2021-09-29" version="1">MPSSERTLADELRSRLKRRRCDIHRYLDGLFYEDCRRVLESVSELDSNHLFLRNPSSLPDYAQHVPRPMYWELIQRKLQRYEYKAAADFMADMRAIVNNCYLYNGIEAPASQLARAMEVLMEDRFVTELRAAPVPPAEVKRACTGMSSADSREILRIYSLYEGIEVGSMVGSTNIQLRTAKSATLRRMIEYARSSAEHREKKAKLRRAAKVSRVSDRRRQAVAGAHATVIQQDADVEFHQDAEPRLEQVPQNAPTAMPIIDEVSPIRIVEEGEWLDDGDFEESSQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GWA9</accession>
    <name>A0A836GWA9_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_07030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000018">
        <property type="protein sequence ID" value="KAG5481319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063998.1">
        <property type="nucleotide sequence ID" value="XM_067208935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GWA9"/>
    <dbReference type="SMR" id="A0A836GWA9"/>
    <dbReference type="GeneID" id="92362869"/>
    <dbReference type="KEGG" id="loi:92362869"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="7"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="407"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5481319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="705" mass="75694" checksum="900E4515689F4080" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GWB7</accession>
    <name>A0A836GWB7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Yos1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_01432</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the YOS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059176.1">
        <property type="nucleotide sequence ID" value="XM_067203485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GWB7"/>
    <dbReference type="SMR" id="A0A836GWB7"/>
    <dbReference type="GeneID" id="92357419"/>
    <dbReference type="KEGG" id="loi:92357419"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013880">
        <property type="entry name" value="Yos1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15858">
        <property type="entry name" value="IMMEDIATE EARLY RESPONSE 3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15858:SF0">
        <property type="entry name" value="IMMEDIATE EARLY RESPONSE 3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08571">
        <property type="entry name" value="Yos1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032560813" description="Yos1-like protein" evidence="9">
        <location>
            <begin position="26"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5466286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="11852" checksum="2F49F06353C4F7D9" modified="2021-09-29" version="1">MGMSIFSLISAVALCLNALAILSESRFLSKFGLATPQALQGGAAPQQETAFNDMVPSSFDADFGSNMNGSGRSSSSVKLQIASLLHSVRLLMRWPLIFVNIILIFLALIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GWL5</accession>
    <name>A0A836GWL5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_01277</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059025.1">
        <property type="nucleotide sequence ID" value="XM_067203334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GWL5"/>
    <dbReference type="GeneID" id="92357268"/>
    <dbReference type="KEGG" id="loi:92357268"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051252">
        <property type="term" value="P:regulation of RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000003">
        <property type="entry name" value="Zinc finger CCCH domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
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</entry>
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            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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            <end position="229"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Jariyapan N."/>
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                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
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            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="1">Belongs to the TBCC family.</text>
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    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GYB1</accession>
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    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000018">
        <property type="protein sequence ID" value="KAG5481359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067208975.1"/>
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    <dbReference type="SMR" id="A0A836GYB1"/>
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    <dbReference type="KEGG" id="loi:92362909"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="2AA_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
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        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
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        <property type="entry name" value="PP2A_Regulatory_Subunit_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648">
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                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Bates M.D."/>
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                <person name="Bates M.D."/>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 8">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family. PFA5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="8"/>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061117.1">
        <property type="nucleotide sequence ID" value="XM_067204080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H803"/>
    <dbReference type="SMR" id="A0A836H803"/>
    <dbReference type="GeneID" id="92358014"/>
    <dbReference type="KEGG" id="loi:92358014"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF23">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="530"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="571"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="10">
        <location>
            <begin position="487"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5472721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="723" mass="79710" checksum="2643EDCC5E1A0F01" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H9U3</accession>
    <name>A0A836H9U3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA pseudouridine synthase</fullName>
            <ecNumber evidence="4">5.4.99.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_02076</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:22376"/>
            <dbReference type="Rhea" id="RHEA-COMP:10085"/>
            <dbReference type="Rhea" id="RHEA-COMP:10087"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.12" evidence="4"/>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061149.1">
        <property type="nucleotide sequence ID" value="XM_067204112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H9U3"/>
    <dbReference type="SMR" id="A0A836H9U3"/>
    <dbReference type="GeneID" id="92358046"/>
    <dbReference type="KEGG" id="loi:92358046"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160147">
        <property type="term" value="F:tRNA pseudouridine(38-40) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.580:FF:000022">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.660:FF:000025">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00171">
        <property type="entry name" value="TruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00071">
        <property type="entry name" value="hisT_truA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF5">
        <property type="entry name" value="TRNA PSEUDOURIDINE(38_39) SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="5">
        <location>
            <begin position="198"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5472753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="499" mass="55480" checksum="AF45B74507872C68" modified="2021-09-29" version="1">MASSSTADDHSAATDSVAASALICGVREVGTLLPTELRVPGTKRKKKAEKAFFFERYPSRKIALRLAYHGHVHDGLAKQKETSNTVEGLVCDALRRLRLVPEDGPHHFGRCGRTDKGVSALGNAFSLTARASCSADAEPQLPPLDYCNMLNSVLPPTIRIVGCALVDDAFDARFSCVHRTYRYYFFHRGLNLPAMQEAAAFLLGTHNFRNFCKMDVVNVSNFVRTVLSVGLHPSEELPELISYLEITANSFLYHQIRCTMEVLFLVGRGLEAPSVVQALLEQGDRKPTYPLADGIPLVLWDCGFENVQWQMSRCAFHAIEQELQDISTALLIRATSASAMRSQLFRWYTGAVDAFVKEQCEKDDVAGKSRSCAVVRRDPEMRRLDRWSVTGCNWTEPSTAGQMKARKRDLLCYLRTDTGKGQTPLATAGGEATNYPAADTAARALLMPMNYVPLLQRETERTYEEEVRELSDKKRARYEVNETKKAAGVSAHKEAVGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HAJ9</accession>
    <name>A0A836HAJ9_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_07550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000004">
        <property type="protein sequence ID" value="KAG5487869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066066.1">
        <property type="nucleotide sequence ID" value="XM_067209434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HAJ9"/>
    <dbReference type="GeneID" id="92363368"/>
    <dbReference type="KEGG" id="loi:92363368"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5487869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="240" mass="25485" checksum="E692AD917A6FEDD4" modified="2021-09-29" version="1">MANSHANTAAATSTSAVKPLSYVSLCSHEGKRIILPVAAAAGSRVLHGIFQGLYVMQLHQSTSPADQSAHEQHEQDGMLEEEVHQGELHIARPGSSDRIAGMAHGSADENEDDPIPIIDEEDDSEEAEVSHPVSGAAYRSYAAVFPSNVTCVPPSLPPQASASPPVALSPCVPPLLDVPIRSLESSTLTRVAEFLVVKITLASHPNCLHQADVFGDLDRTSERDQLVAMQVLLGADFLNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HAW4</accession>
    <name>A0A836HAW4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Arginine N-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_08258</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000003">
        <property type="protein sequence ID" value="KAG5488034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066161.1">
        <property type="nucleotide sequence ID" value="XM_067210128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HAW4"/>
    <dbReference type="SMR" id="A0A836HAW4"/>
    <dbReference type="GeneID" id="92364062"/>
    <dbReference type="KEGG" id="loi:92364062"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016274">
        <property type="term" value="F:protein-arginine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000434">
        <property type="entry name" value="Arginine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF118">
        <property type="entry name" value="N-METHYLTRANSFERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="4">
        <location>
            <begin position="78"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="5">
        <location>
            <begin position="186"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5488034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="405" mass="44174" checksum="EEBBC66BEC701BC9" modified="2021-09-29" version="1">MSAGKNMHAAASKKRGEARSANASKVVLTESLLATDAEKHATSKSLYGDSAARISSNISTIHDHQRLRAYEVIFRNVRGKTLLHLGCGMGLYTMLAARGMAKMVIGIDSSAIVDAARVVAEQNGLKNIQFIRGRLCEVLHQLPDGIKFDYVLCEWMGPLLLNERVLTDALYARDHLLTEAGALCPNRASLHVAAVSDYSFRLDTEDFWSNVYGFQMEPMKELVRQEVEMCAIPGSNIVSAPCLAHTVHMDTLEGLTADETAAYEAQANESAASRDNEEENPVERRWVPAAVAQKGYEAAFTLSISRDATVHYLTFYLDASFTSKTNPGANFVLAVRPGGANNWTEVSVGLREPLPVMAGEKIQGRVRVYTPADKGGKITVVEVTAKTAGQVAVIETSGTYYYQSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HB99</accession>
    <name>A0A836HB99_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Asparagine synthetase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_03602</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061536.1">
        <property type="nucleotide sequence ID" value="XM_067205599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HB99"/>
    <dbReference type="GeneID" id="92359533"/>
    <dbReference type="KEGG" id="loi:92359533"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051857">
        <property type="entry name" value="Asn_synthetase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45937">
        <property type="entry name" value="ASPARAGINE SYNTHETASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45937:SF1">
        <property type="entry name" value="ASPARAGINE SYNTHETASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="17"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="402"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="875"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1138"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="458"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="887"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1138"/>
            <end position="1159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5473533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1233" mass="131698" checksum="C5C77A7131FABFE1" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HBC6</accession>
    <name>A0A836HBC6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_03648</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061581.1">
        <property type="nucleotide sequence ID" value="XM_067205644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HBC6"/>
    <dbReference type="SMR" id="A0A836HBC6"/>
    <dbReference type="GeneID" id="92359578"/>
    <dbReference type="KEGG" id="loi:92359578"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14079">
        <property type="entry name" value="STKc_AMPK_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000929">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="36"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="496"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="630"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="724"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="634"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="729"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5473578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="816" mass="88600" checksum="E6FC42AB7D567BB7" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HFL1</accession>
    <name>A0A836HFL1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1935 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_06205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000020">
        <property type="protein sequence ID" value="KAG5480438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063769.1">
        <property type="nucleotide sequence ID" value="XM_067208129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HFL1"/>
    <dbReference type="SMR" id="A0A836HFL1"/>
    <dbReference type="GeneID" id="92362063"/>
    <dbReference type="KEGG" id="loi:92362063"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015232">
        <property type="entry name" value="DUF1935"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036310">
        <property type="entry name" value="Smp-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47047:SF3">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47047">
        <property type="entry name" value="PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09149">
        <property type="entry name" value="DUF1935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101601">
        <property type="entry name" value="Smp-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1935" evidence="2">
        <location>
            <begin position="12"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5480438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="151" mass="17018" checksum="4F03A96BFCE50FB2" modified="2021-09-29" version="1">MGNKSSHDQGEYRYGGPTNFPHDEKVPLFEERNGLLFRLVNNADRCWGFYSDTKKYEFHVTVTFGPESRNLQALGNTYLCENPDGGWMAKTIVYPCLTEPFIQGDVVGFNLVVNAVLLTTEYKERVKEEKKAAKKAAKEAGNSDELGSNTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HGL2</accession>
    <name>A0A836HGL2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Guanine nucleotide-binding protein subunit beta-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_06473</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat LST8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000019">
        <property type="protein sequence ID" value="KAG5480903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063904.1">
        <property type="nucleotide sequence ID" value="XM_067208392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HGL2"/>
    <dbReference type="GeneID" id="92362326"/>
    <dbReference type="KEGG" id="loi:92362326"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037588">
        <property type="entry name" value="MLST8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842">
        <property type="entry name" value="G BETA-LIKE PROTEIN GBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842:SF0">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX SUBUNIT LST8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="727"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="347"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="440"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="480"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="585"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="351"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="454"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="585"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="599"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="620"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="663"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="678"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="705"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5480903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="793" mass="82319" checksum="1F1C12FEDAE952F2" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HKQ9</accession>
    <name>A0A836HKQ9_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_08251</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG5488282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067210228.1"/>
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    <dbReference type="KEGG" id="loi:92364162"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    </feature>
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        <location>
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            <end position="228"/>
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        <location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="443"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="531"/>
            <end position="585"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="855"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="961"/>
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        <location>
            <begin position="1035"/>
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        <location>
            <begin position="63"/>
            <end position="72"/>
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        <location>
            <begin position="98"/>
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    </feature>
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        <location>
            <begin position="889"/>
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            <begin position="1053"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5488282.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1064" mass="110589" checksum="6479083DED0234BB" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name type="scientific">Leishmania orientalis</name>
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        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
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                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">LSCM4</strain>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="EMBL" id="KAG5479290.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
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    </evidence>
    <sequence length="412" mass="44205" checksum="892F30A695C08E4C" modified="2021-09-29" version="1">MRSDIAGDSSREHRTDSLSVSGVSTASSGPASTPPVTVRFVTSEQEFAAVFGHGGGTPSASSNGGDAFLLCYEYPSDGVTADGILQFQKRVATAAQQYGARLSLYIWDCTSSSFAAARAQLGKSRGHPLLLIVFKGTIADTLRDMPLAEMSATEVPQVCRRLASFQSSANPARVVTSGARRTPASFIAAATSMAESRGDGSSQEEGVEQQLLVDVAKMVGMGKRLMAERKPLYAEKFFAKALLILDAVADDVDRLVASREDYDGSVALCLGWAGLAQLVQGKQIVENAYLERLGRQAAFQPFRDEPLSDANRAMTTWRLMQGAPRSWSETRDSEAKLRAALSSNVQDTVSRCLLVITLFLKGDLERAMTEALKLHISGDAFGRAALKHMSCFLGKEHVLVQRLGMPALVGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HNM6</accession>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name evidence="2" type="ORF">LSCM4_07027</name>
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        <name type="scientific">Leishmania orientalis</name>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000018">
        <property type="protein sequence ID" value="KAG5481316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063995.1">
        <property type="nucleotide sequence ID" value="XM_067208932.1"/>
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    <dbReference type="KEGG" id="loi:92362866"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5481316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="244" mass="27019" checksum="A85BB994ABDAB47D" modified="2021-09-29" version="1">MRLIRPALATRSAAAACAATRCLQQGRAGPPGYTPPPAGTSSGSTVAAVTSSPRSSSSSAKAPVTSLQLDDTDEWIMSFVQRSVDSGRQSQETADYFRSIMHEESDFRQCLLEARRLIGDHDPEKLTRYQQGQFADRLSTYMSGIASEKLRRAHAEEQSTKRYTQDGTPTGENYWFEAGNALSSPAVPGYVKDEILKDMQHERSAKSAAYLQPAEEEQLAAEDDDYAAHLRRQRHKLLRDADFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HQ44</accession>
    <name>A0A836HQ44_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Plastid-encoded RNA polymerase subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_06449</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">In plastids the minimal PEP RNA polymerase catalytic core is composed of four subunits: alpha, beta, beta', and beta''. When a (nuclear-encoded) sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000019">
        <property type="protein sequence ID" value="KAG5480880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063881.1">
        <property type="nucleotide sequence ID" value="XM_067208369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HQ44"/>
    <dbReference type="SMR" id="A0A836HQ44"/>
    <dbReference type="GeneID" id="92362303"/>
    <dbReference type="KEGG" id="loi:92362303"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07032">
        <property type="entry name" value="RNAP_I_II_AC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.120.12:FF:000027">
        <property type="entry name" value="DNA-directed RNA polymerase, alpha subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033901">
        <property type="entry name" value="RNAPI/III_AC40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF13">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="8">
        <location>
            <begin position="121"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00026088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5480880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="448" mass="48245" checksum="E4A3E6F6E8B1C27F" modified="2021-09-29" version="1">MSKARRDVDKVQIGYHRAENTETVSSPHTYAYNSGKSVPSTSKPDKPTVSNIRITSAVAGLPPSSFAAKAPLKLEKNEVKLESGTAAAGSACSSATLGHGVESEARTTVNGFPWSTRRVERMSFEMQHVSPPISNLFRRVLMTEVPTLAFDRVLIEENDSPVLDELLSHRLGLIPVAGPVMKMQYITESNQASFTNLDPSRVLLFELDATGAKDAAVTPVYSRQLQWVPLPGQEKRGDAKADAAARVCQAGSEEGSGAAGAPKRCPDDDEDAVFLVHPDILLTKLGPGQRIKLKAIAVKGFGAVHAKWSPVSVCYYEMKTSVELCERLTGSAAEALVNSCPTGVFGYEGGQTGAAVTVVAPEKCTLCRECLRSDGKAAAAVANEGERVRVQKDKTHILFHIESVGQLHPTQILRFGLRLFAERCRALAEMVQSTEVHVVDASAKSLEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HSI5</accession>
    <name>A0A836HSI5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">P-type Cu(+) transporter</fullName>
            <ecNumber evidence="2">7.2.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">LSCM4_06904</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.8" evidence="2"/>
    <dbReference type="EMBL" id="JAFHLR010000017">
        <property type="protein sequence ID" value="KAG5481828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064188.1">
        <property type="nucleotide sequence ID" value="XM_067208814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HSI5"/>
    <dbReference type="SMR" id="A0A836HSI5"/>
    <dbReference type="GeneID" id="92362748"/>
    <dbReference type="KEGG" id="loi:92362748"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140581">
        <property type="term" value="F:P-type monovalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000029">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000144">
        <property type="entry name" value="copper-transporting ATPase 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF369">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0186">Copper</keyword>
    <keyword evidence="7" id="KW-0187">Copper transport</keyword>
    <keyword evidence="13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="346"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1016"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1046"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="17">
        <location>
            <begin position="58"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="659"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAG5481828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1135" mass="122237" checksum="05EA0CAE76229F85" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HTL5</accession>
    <name>A0A836HTL5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000016">
        <property type="protein sequence ID" value="KAG5482368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064374.1">
        <property type="nucleotide sequence ID" value="XM_067207560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HTL5"/>
    <dbReference type="GeneID" id="92361494"/>
    <dbReference type="KEGG" id="loi:92361494"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032715316" description="Secreted protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5482368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="71" mass="7735" checksum="530E8B80E1D25442" modified="2021-09-29" version="1">MPPLGTPSLLFALLGGLTTHRAREQRRVARQVGNGSLACLLCGGRGTNRRRCVAAVQRLLVLQRRRGADEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HW80</accession>
    <name>A0A836HW80_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_06049</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="JAFHLR010000011">
        <property type="protein sequence ID" value="KAG5485411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065148.1">
        <property type="nucleotide sequence ID" value="XM_067207974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HW80"/>
    <dbReference type="GeneID" id="92361908"/>
    <dbReference type="KEGG" id="loi:92361908"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF448">
        <property type="entry name" value="PALMITOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="401"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="515"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="551"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="9">
        <location>
            <begin position="470"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="84"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5485411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="621" mass="67536" checksum="E88C5040E019CBA8" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HWB4</accession>
    <name>A0A836HWB4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Guanine nucleotide-binding protein-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_04901</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000014">
        <property type="protein sequence ID" value="KAG5483748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064687.1">
        <property type="nucleotide sequence ID" value="XM_067206878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HWB4"/>
    <dbReference type="SMR" id="A0A836HWB4"/>
    <dbReference type="GeneID" id="92360812"/>
    <dbReference type="KEGG" id="loi:92360812"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002139">
        <property type="entry name" value="GTP-binding protein YPT10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="371"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="371"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5483748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="433" mass="44654" checksum="4C79DB5F6109C37D" modified="2021-09-29" version="1">MLECTDSCGSQDTMDKQDAAHEVDHLREIECLAAVHLTSTTDASSSSLATTSHAAASLIMSVVDPSPSSSSHAAAPSARTYAASPRPLSTSISSDTCTSAGGALLVPAAVGQHSGYLRTYKVLIVGEAGVGKSNLMQRYCYNQYDPTLPSTIGVEFCSREVKIPFGPVGATETVVLQLWDTAGQERNAGVISNAFYRNAVGAIIVYDVTRHESLLNVPRWAARVTELARDDCVCIVVGAKLDLLDADKVTASSTTTSGSLEALQQEADRISHAMGMRNFMTSALSGKGVLEAFAHLVLAVDAVQAAPLHKSGTLCGTYLAGHSGHAGGDPVQNSRMQTAAASVSASPMDGMGGADGPHCQLGIDEDVASLSQPRAASTQVMSGHTGASHAASWGQPQPPWVAKKTLDLRGFGPTLAEPGASAASPACSGARGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HXC0</accession>
    <name>A0A836HXC0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Surface antigen-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_06746</name>
        <name evidence="5" type="ORF">LSCM4_06747</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <location>
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        </location>
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            <begin position="220"/>
            <end position="230"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="538"/>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="584"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5466474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="601" mass="62933" checksum="E3E0B08CD7F2FA29" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836K9C1</accession>
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            <fullName evidence="4">MORN repeat-containing protein 5</fullName>
        </recommendedName>
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        <name evidence="2" type="ORF">LSCM4_00409</name>
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        <name type="scientific">Leishmania orientalis</name>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464961.1"/>
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    </dbReference>
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        <property type="entry name" value="MORN repeat, putative"/>
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    </dbReference>
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    </dbReference>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5464961.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="36000" checksum="94F5CB989F3D1DD0" modified="2021-09-29" version="1">MDAVKTYTYKSGAVYEGTFDGNMRSGRGHWAHPQGETYEGEYKDNKQNGLGVYIFSETGKRYLGNWVAGQMSGEGLYFFNRDRTAYYFGNYTKDKKDGDGHYMYETGVMTTQRWNMGALVREEETSPSDIVECMVRLKGLVDAVRAVAPKEMGEMPPPSEVRTFQFPSGATYTGQYFGTKKHGRGYWLHPEGDSYEGQFDNNHHSGWGVYVIGRSGKKYVGHWYNGKMNGIGVYFFNPQETEYYVGLYRDDVKNGRGMYHFAESGTSMVQMWENGVLRQETEADKATEKEYEAAIRKIIGTVRPYAPNYEPVAFVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KA61</accession>
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        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="5" type="ORF">LSCM4_00072</name>
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    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Trypanosomatida</taxon>
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        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058263.1">
        <property type="nucleotide sequence ID" value="XM_067202162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KA61"/>
    <dbReference type="GeneID" id="92356096"/>
    <dbReference type="KEGG" id="loi:92356096"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
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    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="MAPK"/>
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    </dbReference>
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            <end position="103"/>
        </location>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5464632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="254" mass="27203" checksum="1144F7E8244EE86E" modified="2021-09-29" version="1">MWSVGCILGELMLGKPIFPGRSTTNQLELICSVTGMPSAADVSATNSQFAHAMLRDIHFTHRRTFAELLPSASPDALDLIQRLMCFNPNRRITAAEALEHPYVAAFHRPDEEPVAADPITISLPDNERLPLDKYRDAIYEQIAALRRGCASGEQRQRTERQTTGSTVPRRASSGAAASGSRVGTGTSSITRTTASSSAATRSAPQRSSAKSTSTSAANDSVASRSYARPAFRPATTTSSGLEGRPVVREAAVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836KAA2_9TRYP</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="1" type="ORF">LSCM4_01273</name>
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    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
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        <lineage>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059021.1">
        <property type="nucleotide sequence ID" value="XM_067203330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KAA2"/>
    <dbReference type="GeneID" id="92357264"/>
    <dbReference type="KEGG" id="loi:92357264"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5466131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="103" mass="11105" checksum="2583C1D2BBB6A6F5" modified="2021-09-29" version="1">MQNYVEVNMQCSNRDEARANRLTYCGATVGRFVPDSSDFSIPINADKPTIDGVTDGYLGAKWSFAFSATAINYTSPYIGNTVPGELPLKVAVTSARAVHKRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KE60</accession>
    <name>A0A836KE60_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Present in the outer mitochondrial membrane proteome 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060199.1">
        <property type="nucleotide sequence ID" value="XM_067204647.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836KE60"/>
    <dbReference type="GeneID" id="92358581"/>
    <dbReference type="KEGG" id="loi:92358581"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35615">
        <property type="entry name" value="PRESENT IN THE OUTER MITOCHONDRIAL MEMBRANE PROTEOME 22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35615:SF8">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1176"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1177"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1198"/>
            <end position="1220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5469222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1566" mass="165413" checksum="7F97A0A40147DBA4" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KFA3</accession>
    <name>A0A836KFA3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Iron/zinc transporter protein-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_03421</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">LSCM4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060978.1">
        <property type="nucleotide sequence ID" value="XM_067205426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KFA3"/>
    <dbReference type="GeneID" id="92359360"/>
    <dbReference type="KEGG" id="loi:92359360"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF44">
        <property type="entry name" value="PROTEIN ZNTC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="191"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="246"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5471861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="442" mass="46750" checksum="DB08EFAA4D6D57BF" modified="2021-09-29" version="1">MATPSLSVEASARYLMGLGYVLSGPLNSEGSTSAEPQVKQRSLCDGFTGSYSVGLHVGALFLILFVSLLGTAIPILGKCIPWLVKYPFVFSAAKSAATGVLLSVSTIHLIFEGAEAFTEECIPPSLKKYAPLYFLIAMIAVLLMQALDMQLADIAERWMKAKLKAEAEATKAGAKGDEDFRELSAEVKVGVTSGPAQTEGPLSEEPVELRTTGPSPFEREGTNGESCVEPRVPVAATEGGEAALTMPSPEQHDHRGESVSHGHQHLTAAPPSNMGTIRRVISALCMEFGVTLHSVFVGLTVGLTTDGELKPLIVALVFHQLFEGMAMGSRLAEAEFKGNLEIILALVFSFSAPVGMAAAAIAVSVSPSTMSGSGFTTLVAVLDTFCGGILLYLAFTLLLGDFVADVKHYCAEGQKYRTVKKIILFAAVWAGMGLMALVGNWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KHW3</accession>
    <name>A0A836KHW3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_01337</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059083.1">
        <property type="nucleotide sequence ID" value="XM_067203392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KHW3"/>
    <dbReference type="SMR" id="A0A836KHW3"/>
    <dbReference type="GeneID" id="92357326"/>
    <dbReference type="KEGG" id="loi:92357326"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="126"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="338"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5466193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="450" mass="48937" checksum="746B481780F705D8" modified="2021-09-29" version="1">MAPVNVEKVNSVFHLFAVDAHAGAAAARDEMCESYIPVFFLAAAAREMGYYPTPSAIHQFTETVRDTPAGAVTFAAFLQFCESVAHTSQPGRSVIYKMIDDINPRGSGLISRHELLLVLTSGSVNITESEIDAAMELLDPTNSGCIRLSDLAAVLIDSCERRRQHEPSVAPTGASEKRHQPSHSTNSIAAAIPRAGSPPPRPRQGQQRQHSNKTRRCHSRKTTAQPEDRKQYQKPQRGFLKKRVYETPPPPPLATAAAEWERAQALGQPWCSITARECGGSLRCTDRNSANEGVCRPHESLHSRQDTFEWAQTVMTVDVDVQPSVRHHTPTVRLRKFASSSSPAASSLAAPTPLRPFRPAAPAPAAGETPLHEKAEENGQPHPHPGNRAGADGGGRRDESLEGELEQPRRFRCLGLSTGVDRSCAAERAPAMPTSRLSKTSHGLKCCIML</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KIZ8</accession>
    <name>A0A836KIZ8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">VPS37 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_03795</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061728.1">
        <property type="nucleotide sequence ID" value="XM_067205791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KIZ8"/>
    <dbReference type="SMR" id="A0A836KIZ8"/>
    <dbReference type="GeneID" id="92359725"/>
    <dbReference type="KEGG" id="loi:92359725"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009851">
        <property type="entry name" value="Mod_r"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07200">
        <property type="entry name" value="Mod_r"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS37 C-terminal" evidence="7">
        <location>
            <begin position="133"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="162"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5474622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="286" mass="31975" checksum="D1EB84446D5B1FC4" modified="2021-09-29" version="1">MAQDRNGQLEELRRQFPSTSVVTESAQETVLKVDHVVRISLTAEYALSLYVTLPSAFPKAAPRATMPYCCHNVPITPPYTNPSEASAYQWSSAASTLVEAVRNAFQNAADCWGPVEPPSMHGITLQLSGETNRLLQDLVTNPNCLDAYCYQLPIIKLMREASRQTISEIERVANENTRLRNEVETLEGQVKDLQQRLGEEVAHLQQLGQNRLLASVGTPEALIKTLEEDVRKMSSDCMAVGKRALDAYKSDKDGFQDLLEQYKAQSKEMHMLDLKRISYRAQCAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KJ98</accession>
    <name>A0A836KJ98_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Guanine nucleotide-binding protein subunit beta-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_00787</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059510.1">
        <property type="nucleotide sequence ID" value="XM_067202860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KJ98"/>
    <dbReference type="SMR" id="A0A836KJ98"/>
    <dbReference type="GeneID" id="92356794"/>
    <dbReference type="KEGG" id="loi:92356794"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001734">
        <property type="entry name" value="WD domain, G-beta repeat, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039241">
        <property type="entry name" value="Rrp9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19865">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19865:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="270"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="458"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="437"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="497"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="700"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="718"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5467708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="751" mass="80088" checksum="97ED09B0F2C946A1" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KJ99</accession>
    <name>A0A836KJ99_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycosomal membrane like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_05296</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5477904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062811.1">
        <property type="nucleotide sequence ID" value="XM_067207243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KJ99"/>
    <dbReference type="GeneID" id="92361177"/>
    <dbReference type="KEGG" id="loi:92361177"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008733">
        <property type="entry name" value="PEX11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05648">
        <property type="entry name" value="PEX11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5477904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="23574" checksum="CF001D622E7CE733" modified="2021-09-29" version="1">MSVVSTLTTYMAATDSRDKMIKGAGCFFKMMGALNGNANFVKVGAAMSDARCLLRILSWLGNVQKISDAMEKRIVQPRDILFVLRVLFDGIFSLLDNIVFTGRFFDHKSLSLTQMSHVSRASLFYGYVMAVALDIYDLLRDPNMPKRGDRCLVLTRNACDMVSAIGNVCTLDIGAANVAGLGLISAIIATREQLIAAAAKSGGNTLGPAPAKAAASPSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KJH5</accession>
    <name>A0A836KJH5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BolA-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_05499</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the BolA/IbaG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5478099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063006.1">
        <property type="nucleotide sequence ID" value="XM_067207438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KJH5"/>
    <dbReference type="SMR" id="A0A836KJH5"/>
    <dbReference type="GeneID" id="92361372"/>
    <dbReference type="KEGG" id="loi:92361372"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.90">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052275">
        <property type="entry name" value="Mt_Fe-S_assembly_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46188">
        <property type="entry name" value="BOLA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46188:SF1">
        <property type="entry name" value="BOLA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003113">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5478099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="88" mass="9550" checksum="3FB88A47583E0817" modified="2021-09-29" version="1">MFRIAPRLLVAYTAADIQAKLESSEALKPVQSVSVVDTSAGCGSFFDIDIVSPVFEGKSLIQQHRLVNSVLKEEISAIHGFTLNTKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KJK6</accession>
    <name>A0A836KJK6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_01157</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5468068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059870.1">
        <property type="nucleotide sequence ID" value="XM_067203220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KJK6"/>
    <dbReference type="SMR" id="A0A836KJK6"/>
    <dbReference type="GeneID" id="92357154"/>
    <dbReference type="KEGG" id="loi:92357154"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00027">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="5">
        <location>
            <begin position="22"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="6">
        <location>
            <begin position="235"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="111"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="114"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="148"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5468068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="410" mass="43784" checksum="5E9ADE4367BA1D18" modified="2021-09-29" version="1">MSTVAYALVAQEKQYPLQVGKNVIGRSSVPVEGVSFINLESPLSAISRMQAFLDIGANGDAWISDCNSTNGTFVSIRPGPGMRLEANRYYQLSPGCRIVFGDVACTFESLSEAPPTQESPARSLTSPSRSTRKTESLGAVGAFVESAAKTTPARQPPKQTTAHRRDLPYLDEGDSLSLVPTAPSARTATTKKTRRRNLPGPTTPPQPLKLSKVESVTPSSAPEMKVAPTAKGTPVAPSLAIGLNVCLTGMDSEEREAIAKRVRQLKGHLVDDITKANLLVVATPPVRTPKFIAAVARSIPVVSVAYICNDRDKLDDARHHIVGLKTDQHTYTAAELRKVIYRKDASPLLQGITFNIAALSSKTKKVAAEIIASSGGDVVRAKKGGGIVLTDAQLDRLYDSILRGKVSHAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KKE8</accession>
    <name>A0A836KKE8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Guanine nucleotide-binding protein subunit beta-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_02346</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5468953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059930.1">
        <property type="nucleotide sequence ID" value="XM_067204378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KKE8"/>
    <dbReference type="SMR" id="A0A836KKE8"/>
    <dbReference type="GeneID" id="92358312"/>
    <dbReference type="KEGG" id="loi:92358312"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF8">
        <property type="entry name" value="FI02843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="500"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5468953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="728" mass="76839" checksum="5C4654928728A570" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KLX6</accession>
    <name>A0A836KLX6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_01800</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">LSCM4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000022">
        <property type="protein sequence ID" value="KAG5479211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063304.1">
        <property type="nucleotide sequence ID" value="XM_067203845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KLX6"/>
    <dbReference type="SMR" id="A0A836KLX6"/>
    <dbReference type="GeneID" id="92357779"/>
    <dbReference type="KEGG" id="loi:92357779"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000005">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000027">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000328">
        <property type="entry name" value="Proteasome regulatory ATPase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048723">
        <property type="entry name" value="OB_PRS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21236">
        <property type="entry name" value="OB_PRS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="214"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5479211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="437" mass="49035" checksum="4FD71D448AA76D4D" modified="2021-09-29" version="1">MPNEKGACQTKNTVRVKDDDKEEKEIVPLDKDDIALLNLYGSGPYHASIKELEEFVKSRVEELNKMGGMKESEMGLAPAVQWDLNSDQKVLERENPLHVGRCERILNKGQDDARYVISIRDHAKYVVTIGERVAPEDIEESMRVGIVMGYSKIQIEIPLPPRIDRSVSMMQVEDKPDVTYADVGGVKEQIERIREVVELPITHPEKYTQLGIDPPKGVLLYGPPGTGKTLLAKAVANRTDATFIRVIGSELVQRYIGEGARMIREIFQLARTKKACIIFFDEVDAVGGSRGSGDGDDEIQRTMLEMVNQMDGFDSRGNIKVIMATNRPDTLDPALTRPGRMDRKLEIGLPDLEGRTNILRIHSRSLSCEKDVRFELIARLCPNTTGADLRSVCTEAGMFAIRARRKTINEKDFLDSVNKVVKGQHKFSATAKYMVYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KML1</accession>
    <name>A0A836KML1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_05076</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062353.1">
        <property type="nucleotide sequence ID" value="XM_067207050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KML1"/>
    <dbReference type="SMR" id="A0A836KML1"/>
    <dbReference type="GeneID" id="92360984"/>
    <dbReference type="KEGG" id="loi:92360984"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024586">
        <property type="entry name" value="DnaJ-like_C11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052243">
        <property type="entry name" value="Mito_inner_membrane_organizer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44157">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44157:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11875">
        <property type="entry name" value="DnaJ-like_C11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="36"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="177"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="201"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="232"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5476120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="825" mass="90991" checksum="27E68824B86E3336" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KNP9</accession>
    <name>A0A836KNP9_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_04463</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062656.1">
        <property type="nucleotide sequence ID" value="XM_067206447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KNP9"/>
    <dbReference type="GeneID" id="92360381"/>
    <dbReference type="KEGG" id="loi:92360381"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5477245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="59" mass="6604" checksum="811C751EF4BBE33A" modified="2021-09-29" version="1">MPVSEMARTTAHASFATLQLYLCCGLLDTIRESPMLSVVAKLLGRKGRKERAFMCRRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KNX4</accession>
    <name>A0A836KNX4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_02071</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061144.1">
        <property type="nucleotide sequence ID" value="XM_067204107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KNX4"/>
    <dbReference type="SMR" id="A0A836KNX4"/>
    <dbReference type="GeneID" id="92358041"/>
    <dbReference type="KEGG" id="loi:92358041"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00106">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000579">
        <property type="entry name" value="Kinesin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF15">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="5"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="722"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="844"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="425"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="722"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="757"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="848"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="861"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="881"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="912"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="91"/>
            <end position="98"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5472748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1211" mass="133643" checksum="6A422F58DE5402E0" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KNZ6</accession>
    <name>A0A836KNZ6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GH18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_05615</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000016">
        <property type="protein sequence ID" value="KAG5482359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064365.1">
        <property type="nucleotide sequence ID" value="XM_067207551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KNZ6"/>
    <dbReference type="SMR" id="A0A836KNZ6"/>
    <dbReference type="GeneID" id="92361485"/>
    <dbReference type="KEGG" id="loi:92361485"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00598">
        <property type="entry name" value="GH18_chitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032686441" description="GH18 domain-containing protein" evidence="6">
        <location>
            <begin position="22"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="7">
        <location>
            <begin position="60"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="419"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="436"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5482359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="456" mass="50602" checksum="70843A2AC97A6554" modified="2021-09-29" version="1">MVPRSALVLLSCLAVVLHSSSLGILLSTTVAAAAPAAERDTATSSSRNTSATDASPSPLFTVFGYLPEYRQASFNYEAFFKSGLSHLIFFSAEVDPANLRLTHVDDRLPSDGEWARIRRLADVHGTKLMLCIGGGGRSAGFADLVGDKARRLAFIEEVNTVLLVRRLDGIDFNWEYPQSMTEWSNFGRFLLELRSTLGYATAAGGEHSAGAIDGRRHRTLVRRVILSMALHPHASIPAVLQSARVLQSLDYIHWMAYDHVAANEPHSSVEYAASVLSEEVIGLFSEATYSRRRGKTHRRSRAEQDHRRKLTLGIPFYGRHRENRRLQPETYGRLWLLIQQWARKRHPAWIEGGAELRALSEYDGYSFTGYDDVKRKMRLARAANLSGIMIWELGQDVPPGTSPMSLMTAVREQLTDWGLLTDSGHGSDGGVNADGAQHRQLQEPHPSRNAAEDGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KNZ7</accession>
    <name>A0A836KNZ7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Leucine-rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_02147</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061219.1">
        <property type="nucleotide sequence ID" value="XM_067204182.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836KNZ7"/>
    <dbReference type="GeneID" id="92358116"/>
    <dbReference type="KEGG" id="loi:92358116"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18849:SF0">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 410-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18849">
        <property type="entry name" value="LEUCINE RICH REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
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</entry>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
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            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <comment type="similarity">
        <text evidence="2">Belongs to the SAS10 family.</text>
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    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <begin position="483"/>
            <end position="555"/>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
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            <begin position="281"/>
            <end position="350"/>
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        <location>
            <begin position="393"/>
            <end position="538"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
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            <end position="320"/>
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            <end position="348"/>
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            <end position="435"/>
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            <end position="457"/>
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    </feature>
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            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
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            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="497"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF09368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5474638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="555" mass="62287" checksum="1E2E48BDFA7208BF" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KRN1</accession>
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        <recommendedName>
            <fullName evidence="4">Leucine-rich repeat protein</fullName>
        </recommendedName>
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        <name evidence="2" type="ORF">LSCM4_07923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000013">
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        <property type="molecule type" value="Genomic_DNA"/>
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            <end position="276"/>
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    </feature>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
            <dbReference type="EMBL" id="KAG5484356.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="905" mass="94751" checksum="5863D47950AE5659" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836KRN2_9TRYP</name>
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        <recommendedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </recommendedName>
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    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Kinetoplastea</taxon>
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            <taxon>Trypanosomatida</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000015">
        <property type="protein sequence ID" value="KAG5483082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067209195.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="92363129"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR12350:SF5">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
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            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5483082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="399" mass="45472" checksum="37A6DB74540A4A63" modified="2021-09-29" version="1">MLHRTGGSRCFGKVLYGSSSTLPGDFFHCCTTHFGAHLHEETFIGTRSSQHRGMFLSHTRGAPLPANKALATIPLARLLTVSNIATRPNALPHVTLAKVRDAIADDEFRMMAPQFYLGLQMSAIIAAIPDITRACSAAEVSRITDLLRVGAAPYARMLDDEDFNEEFVFGMYGMALDSWQRTSYEEMTKKYHLALTAIHDAVDPPFKLEHFQRITRLVLARAEHVPPVDYYNGNLFLRRLKRRWRRMRKIPEPTELALVPYLDLVNHSNRPNCAIRIGPSPTFNGEGAITLFTLREVLPGQELCRHYNFALDRASALFRYGFLPFDLISIIDHDAVDEHIVKTRGMFRPESAERLERWRQEAKEVARLEKLFQAAKQGGITRDWQPDPSLNDRVSRRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KS25</accession>
    <name>A0A836KS25_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_05112</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062386.1">
        <property type="nucleotide sequence ID" value="XM_067207083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KS25"/>
    <dbReference type="GeneID" id="92361017"/>
    <dbReference type="KEGG" id="loi:92361017"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF99">
        <property type="entry name" value="BIFUNCTIONAL PEPTIDASE AND (3S)-LYSYL HYDROXYLASE JMJD7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="2">
        <location>
            <begin position="313"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="483"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5476153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="590" mass="64870" checksum="6803CA5459763690" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KSG7</accession>
    <name>A0A836KSG7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ARP2/3 complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_06647</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000010">
        <property type="protein sequence ID" value="KAG5485689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065273.1">
        <property type="nucleotide sequence ID" value="XM_067208562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KSG7"/>
    <dbReference type="GeneID" id="92362496"/>
    <dbReference type="KEGG" id="loi:92362496"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034666">
        <property type="entry name" value="ARPC2/4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69645">
        <property type="entry name" value="Arp2/3 complex subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5485689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="418" mass="44929" checksum="3E5BEDAF2E140E47" modified="2021-09-29" version="1">MSVMKGPTRLPNTSPLPALMAAVKLFEDKRLTVSSPRPVPPHLLHTFTGCIYELASLQKGNASEATSEPLSQRLFSHITTAITTEAAVLRSSSDSDTKGSCEHAPAAEAGVASSPTAESTCLSTTASYPPISIRFVCPIPYSQLNQFDNLVHVLSTALRQVAPHCVYGLPSPSDMGLTFTAAKPLSSVGLCIPAEVTPRERAAAVAFAADLSVRAFQPVVEGLLQRSCATLQQESVLLLPRIDTAVETTGSQRVVDTEAIFSASALFVTATPTPAALAPTDTRSSTGAGSAPFYAGTVSLTVCIGTDDEGDAARIRRYLTAFTEVERAPVLLLVRESPEPPLGVSAAPDWTVKAEHSHVWWCSFVFAPHQITSAASLRRGLRWARELRPTVLFHVHQERMAMHAQLRQQLRKYVGHFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KSS0</accession>
    <name>A0A836KSS0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small Rab GTP binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_07863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000013">
        <property type="protein sequence ID" value="KAG5484297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064790.1">
        <property type="nucleotide sequence ID" value="XM_067209740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KSS0"/>
    <dbReference type="SMR" id="A0A836KSS0"/>
    <dbReference type="GeneID" id="92363674"/>
    <dbReference type="KEGG" id="loi:92363674"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01860">
        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000823">
        <property type="entry name" value="Small GTPase RAB, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5484297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="22753" checksum="924C8BDC08DEE7B4" modified="2021-09-29" version="1">MSSVSRATATTTGAPASARKFKLVLLGESGVGKSSVVQRLMKRAFSDKLNSTVGASFFRYTCDVGDGTAVHFDIWDTAGQERFRSLASMYYRGAAAALVVFDIVSTDTYERAKHWIRELHVNSPETLVMLVGNKKDLEGERQVTLAEAQQCAAEMGAMYGETSARSGDGVQEAFHAIAAKLVETNSTVSVRGGGVLGHTENTVTRRENECC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KT61</accession>
    <name>A0A836KT61_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">VASt domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_06911</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000017">
        <property type="protein sequence ID" value="KAG5481835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064195.1">
        <property type="nucleotide sequence ID" value="XM_067208821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KT61"/>
    <dbReference type="SMR" id="A0A836KT61"/>
    <dbReference type="GeneID" id="92362755"/>
    <dbReference type="KEGG" id="loi:92362755"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140268">
        <property type="term" value="C:endoplasmic reticulum-plasma membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120015">
        <property type="term" value="F:sterol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051482">
        <property type="entry name" value="Cholesterol_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031968">
        <property type="entry name" value="VASt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319:SF4">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16016">
        <property type="entry name" value="VASt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51778">
        <property type="entry name" value="VAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="794"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="domain" description="VASt" evidence="7">
        <location>
            <begin position="508"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="81"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="124"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="172"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5481835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="819" mass="90028" checksum="DBC3BC9A87850B73" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KTU8</accession>
    <name>A0A836KTU8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">40S ribosomal protein S19 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_06251</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000007">
        <property type="protein sequence ID" value="KAG5486786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065580.1">
        <property type="nucleotide sequence ID" value="XM_067208175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KTU8"/>
    <dbReference type="SMR" id="A0A836KTU8"/>
    <dbReference type="GeneID" id="92362109"/>
    <dbReference type="KEGG" id="loi:92362109"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000593">
        <property type="entry name" value="40S ribosomal protein S19 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001266">
        <property type="entry name" value="Ribosomal_eS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01090">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01413">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5486786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="17910" checksum="95416E3B9967430D" modified="2021-09-29" version="1">MTASSNKIRRIGKRKGGTLKDVSAWRWIKTAARHFKQEGKLFVPNCTEIMKSSHGRERAPQNPNWYYIRCAAVLRAIYLRPGVGYGGLSKRFGNKNYGSRPEHTVSSSTGPLHWACKSLTKLGLVEPGAQSGQRLTRKSHKFADALAFQVHIRKFGQAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KU96</accession>
    <name>A0A836KU96_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_07709</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="JAFHLR010000006">
        <property type="protein sequence ID" value="KAG5487221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065718.1">
        <property type="nucleotide sequence ID" value="XM_067209588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KU96"/>
    <dbReference type="SMR" id="A0A836KU96"/>
    <dbReference type="GeneID" id="92363522"/>
    <dbReference type="KEGG" id="loi:92363522"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000001">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0697">Rotamase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033108705" description="Peptidyl-prolyl cis-trans isomerase" evidence="4">
        <location>
            <begin position="25"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="33"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5487221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="190" mass="20536" checksum="ECAD220DEB346EA4" modified="2021-09-29" version="1">MRAVTVVAIVALVLCAVATLNVTAEPAVTSKVYFDITIGDEAVGRITIGLFGNDVPRTAENFRQLCTGEKGFGYKGSIFHRVIPNFMIQGGDFTNFDGTGGKSIYGAKFEDENFKIKHFVGALSMANAGANTNGSQFFITTAATPWLNGRHVVFGKVLEGMEVVRRIEKAKTNKRDRPVKTVKIVASGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KUC1</accession>
    <name>A0A836KUC1_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_07311</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000015">
        <property type="protein sequence ID" value="KAG5483095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064591.1">
        <property type="nucleotide sequence ID" value="XM_067209208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KUC1"/>
    <dbReference type="GeneID" id="92363142"/>
    <dbReference type="KEGG" id="loi:92363142"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014903">
        <property type="entry name" value="DUF1796"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08795">
        <property type="entry name" value="DUF1796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5483095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="405" mass="45114" checksum="011DFA181EC29399" modified="2021-09-29" version="1">MFGGSRRVRQAALFDGASLPRKHISLGGWCGPALMLGKLGLRTEAYPFDFSRVTLDGLMHFIQNGFAEGFYPPGPPPYRPECVGPWVLFRGQHTAFAHFDLNDPRVQAHFQVKMHRFDAVLDAPERPVTFFRTVTARHPQEELALALDLEEAVARRNRSLDFRIVFMVHDQGLRASAVQLAPLSPRVSLWALRYRGLPSDTLFDRTHTAYHAVMLHSVAEENWSAVKVGVVPPPPATMASAEGWDFERNVLVCDGAARTEDVPFADLTITRFPWRSHDNLALIDGVASVGGTCTGIGSTKMLANASAALHVQRLARLKCRYCGDATYHAAGRPFRTDRPFTDEEDQLVLIHLYKILTGGDKVAAVEKLAHEMRRGTYEVICRIQYLTNSSTKLMDSFDPNSLSDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KUE1</accession>
    <name>A0A836KUE1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA(Phe) 7-[(3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4)]-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.282</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_06758</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36635"/>
            <dbReference type="Rhea" id="RHEA-COMP:10378"/>
            <dbReference type="Rhea" id="RHEA-COMP:10379"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73543"/>
            <dbReference type="ChEBI" id="CHEBI:73550"/>
            <dbReference type="EC" id="2.1.1.282"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TYW3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.282" evidence="2"/>
    <dbReference type="EMBL" id="JAFHLR010000009">
        <property type="protein sequence ID" value="KAG5486052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065383.1">
        <property type="nucleotide sequence ID" value="XM_067208672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KUE1"/>
    <dbReference type="GeneID" id="92362606"/>
    <dbReference type="KEGG" id="loi:92362606"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1960.10">
        <property type="entry name" value="tRNA wybutosine-synthesizing-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003827">
        <property type="entry name" value="tRNA_yW-synthesising"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036602">
        <property type="entry name" value="tRNA_yW-synthesising-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48418">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48418:SF1">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02676">
        <property type="entry name" value="TYW3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111278">
        <property type="entry name" value="SSo0622-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA wybutosine-synthesizing protein" evidence="10">
        <location>
            <begin position="67"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5486052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="350" mass="37005" checksum="91C414F6C1F637F1" modified="2021-09-29" version="1">MPDTPPDSSPAPVAAAFQAPPFPPPTKVKPARKESSKMGEVNPRPPAHAHGVSAQQQKQRDKEFVAHKAHILANLQTNACDLSPKGTVDVKCLPVMNVLNTHKDYITTSSCSGRISLFHSITHNEVCEPDNGAAKPRMKRGENAALGWVFVKHGMLRPMEMAQVVRFLCGAAITLEDVALDAAQVKEHAAHMSSVSGSADCDGAASGSSLSGMYDGEVEGVLVDAGASEDEAVALPVPTCGIVSLKMEPFVMHVECRTMEAAKLLLSAAVSDSGYRNSGVVPPGKKIMCGIRSAAGLGLEVPVVIHGVNHVASQRAYVWALLGLANEKMKANEKKIRLLEKCVAARISPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KUE3</accession>
    <name>A0A836KUE3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_04801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000023">
        <property type="protein sequence ID" value="KAG5478568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063229.1">
        <property type="nucleotide sequence ID" value="XM_067206782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KUE3"/>
    <dbReference type="GeneID" id="92360716"/>
    <dbReference type="KEGG" id="loi:92360716"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5478568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="138" mass="16481" checksum="C6B7BFCDDD7357BF" modified="2021-09-29" version="1">MSDPANINHYDARAYTRSGATRRVVVREKPLLKSRMQRIVDYLRPTTRHGFNIVGTFELSKVMICVVFPVFMLLYWKSKEKELPDSWEQQFGGLQHRQFREDEVPERETDYFSIIENFQERREAALQKKREALQSRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KUT3</accession>
    <name>A0A836KUT3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_07499</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000004">
        <property type="protein sequence ID" value="KAG5487821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066018.1">
        <property type="nucleotide sequence ID" value="XM_067209386.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92363320"/>
    <dbReference type="KEGG" id="loi:92363320"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="3951"/>
            <end position="3972"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="197"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="449"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="639"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1043"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2402"/>
            <end position="2427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2550"/>
            <end position="2572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2787"/>
            <end position="2806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2866"/>
            <end position="2898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2967"/>
            <end position="2986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="657"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2558"/>
            <end position="2572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="2866"/>
            <end position="2875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2879"/>
            <end position="2890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2967"/>
            <end position="2977"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5487821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="3992" mass="420270" checksum="F9ECC037A8EDDB13" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KW02</accession>
    <name>A0A836KW02_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_07668</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000012">
        <property type="protein sequence ID" value="KAG5484895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067209547.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="92363481"/>
    <dbReference type="KEGG" id="loi:92363481"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009305">
        <property type="entry name" value="Mpo1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34205:SF2">
        <property type="entry name" value="DUF962 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34205">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06127">
        <property type="entry name" value="Mpo1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5484895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="108" mass="11676" checksum="C418BF727B2436F5" modified="2021-09-29" version="1">MVHLSAKFQVSASNHKEFHIYYLAKHSKQWTRRIHLIGTVVGVAGVAVSTVRMDAIGAAVSAAVGAAICWTGDAVVEQTQPTAFKNPIWSLMSNFKMVASMLKGDMSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KYC1</accession>
    <name>A0A836KYC1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SMP-LTD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
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            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000016">
        <property type="protein sequence ID" value="KAG5482438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064444.1">
        <property type="nucleotide sequence ID" value="XM_067207630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KYC1"/>
    <dbReference type="GeneID" id="92361564"/>
    <dbReference type="KEGG" id="loi:92361564"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027536">
        <property type="entry name" value="MDM34"/>
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    <dbReference type="PANTHER" id="PTHR28185">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28185:SF1">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="239"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5482438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="36409" checksum="8ACE4386EFC0F7E5" modified="2021-09-29" version="1">MLRWDWPQTWSLESREAIRVALETSIRGAMAKGENKVVRGLVHVELPEIGSTPPQVTLTGIRELSLEHTALMVKVRYDGEFSLKLRGLQVNVDTVGANSTLSSDLNLAMPFYCPLEMTLSDIHVDGVASIEVFQEIVDVASSEDVPLLRPDSAMGLTATSRTSNAASFSSPSRVPRSSPSTLSTTHSSTARSSRAGGYPSSGYGVLLGAGGRRAMRPPERTPNSRALAVPPVFTSPQGSPAATTDASLADSSGNCSSAGLSTTPSQPRHSLIDLVSRRAAVKKRRIKVQLFGDPIKRYRVESNLVAVPGAGKKVEEHIQGMLEPLIERLMAEGITIELSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836L419</accession>
    <name>A0A836L419_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Calpain catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_07501</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000004">
        <property type="protein sequence ID" value="KAG5487823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067066020.1">
        <property type="nucleotide sequence ID" value="XM_067209388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836L419"/>
    <dbReference type="SMR" id="A0A836L419"/>
    <dbReference type="GeneID" id="92363322"/>
    <dbReference type="KEGG" id="loi:92363322"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015232">
        <property type="entry name" value="DUF1935"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036310">
        <property type="entry name" value="Smp-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF423">
        <property type="entry name" value="LEUCINE-RICH REPEAT PROTEIN (LRRP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09149">
        <property type="entry name" value="DUF1935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101601">
        <property type="entry name" value="Smp-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="5">
        <location>
            <begin position="296"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="active site" evidence="2 3">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <feature type="active site" evidence="2 3">
        <location>
            <position position="540"/>
        </location>
    </feature>
    <feature type="active site" evidence="2 3">
        <location>
            <position position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5487823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="858" mass="94745" checksum="5F2744A256018E2D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FPA7</accession>
    <name>A0A836FPA7_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_01663</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059402.1">
        <property type="nucleotide sequence ID" value="XM_067203711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836FPA7"/>
    <dbReference type="GeneID" id="92357645"/>
    <dbReference type="KEGG" id="loi:92357645"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="137"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="431"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="305"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="154"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="456"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5466512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="466" mass="51335" checksum="10D1CEBEBCDB211E" modified="2021-09-29" version="1">MSLTGVDDTQRVDVAHLQHLLHKREYHLAELINEVVFAEQERYKAVQEAHGLRELTTRLEGVVNKLLEYNITIHREVLLPVLIDSVRSNDAARSVGASLTEDSTAVGSSKDFIDDLLREPCLSSETKRLLQAVVKQRRKAEQQSSGHTRLHVDASSPSAAPSGSAARTPPVDAEASVTPATRRAIVLSDSLLQSQESLAQLLHTIQAQARDLLRHWNELGGNELQDRQQPLRESTVRRQKSTSEVAPFRLENLHQRSCRVREIEEALRSVEGERDALQAQLRERDATADAAAVAASTQTPAAQPEESWLKEKAELEKELAYAQQRVLQEQARSQELKKQVSQLEKVAAASPITPSEAISSSWTNCEKMREEIKKHNGGLPCRQDSVEGGGAAPAEGDCIPATSSKRACQRSFSAVSVSACQRIGRRTSILRTRARNRTQDRPAGGFSRCLKGRPANHGDAHGNRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FRY1</accession>
    <name>A0A836FRY1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">1,2-Dihydroxy-3-keto-5-methylthiopentene dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_01176</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5468087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059889.1">
        <property type="nucleotide sequence ID" value="XM_067203239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836FRY1"/>
    <dbReference type="SMR" id="A0A836FRY1"/>
    <dbReference type="GeneID" id="92357173"/>
    <dbReference type="KEGG" id="loi:92357173"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010309">
        <property type="term" value="F:acireductone dioxygenase [iron(II)-requiring] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02232">
        <property type="entry name" value="cupin_ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000099">
        <property type="entry name" value="1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004313">
        <property type="entry name" value="ARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418:SF5">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE (FE(2+)-REQUIRING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03079">
        <property type="entry name" value="ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0533">Nickel</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5468087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="32884" checksum="5D00F52ABC5B2CF5" modified="2021-09-29" version="1">MEGISEEQRLREEAEIRERDRKRQLEKENYERRLAEEKAEEERRRREAEQLRVEEEKRKKRQEEEWKRLGPDAIQDLPPVPPPVSEEGALDMWFLDDATSQPPLSTASLKPGRKLGAAPPTMKMLRDLGVVLFRVSMSDFSVVKQIIKERDYKHTDELKISQTAKDDSFMERWYQEHYTEDEQFRVVMDGSFYMDIRSKQDEWIRIHLKAGDLVVLPAGIYRRATLDEDDYVALYRGFQDAPRFLPVKRSDSRADSNRVRLAYLMSLKKGDVATQNGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FZT9</accession>
    <name>A0A836FZT9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 subunit I</fullName>
            <shortName evidence="7">eIF3i</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_00419</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat STRAP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the eIF-3 subunit I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058602.1">
        <property type="nucleotide sequence ID" value="XM_067202501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836FZT9"/>
    <dbReference type="SMR" id="A0A836FZT9"/>
    <dbReference type="GeneID" id="92356435"/>
    <dbReference type="KEGG" id="loi:92356435"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000658">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03008">
        <property type="entry name" value="eIF3i"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027525">
        <property type="entry name" value="eIF3i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877:SF1">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24805">
        <property type="entry name" value="EIF3I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="307"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5464971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="356" mass="38450" checksum="61F5FBF291B6DFFD" modified="2021-09-29" version="1">MTSAVDLEGVALHGHMKGVTMLKFNRDGDLLFSSAKDTNCSACCWQAKTGKLLGSYTTVGQVEGRTYDAAMVALDVNRESTLLATASAGEEVLLWSVESGALLGSVSRSLSSGASVGFSHDDTMMMVATKGRSSTSSAIQVYNVPFTVPKAGEDIAPVKTPFTTFSTFETPDTITWAAWGPTNETIYYAEGGYMNILDVEANKVIRSRQVHEDENEVINRFSWDPNYLTLATASTDKTSHLIDFRDLATIQVYRSDVPVNDVSISPNADHVILGGGMDAAAVTTQGGQSIFEVKFYHKVHGHQLGQLRCHFGTINAIAFHPDGRGFASASYDGLIKMYRFGDAYESAPGAKPLWTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="3" type="ORF">LSCM4_01238</name>
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        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Metakinetoplastina</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466096.1"/>
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            <begin position="373"/>
            <end position="398"/>
        </location>
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            <begin position="236"/>
            <end position="253"/>
        </location>
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            <begin position="273"/>
            <end position="282"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="419"/>
            <end position="428"/>
        </location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5466096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="590" mass="65086" checksum="6BCCF962689A2C3A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G3L3</accession>
    <name>A0A836G3L3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_00134</name>
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    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
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        <lineage>
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            <taxon>Trypanosomatida</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067202224.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="loi:92356158"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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            <begin position="195"/>
            <end position="214"/>
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            <begin position="226"/>
            <end position="252"/>
        </location>
    </feature>
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        <location>
            <begin position="87"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5464694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="368" mass="40101" checksum="04029A263871917E" modified="2021-09-29" version="1">MLMKVSRSNSHASAMLRVCCLQVLSCRTLLRPRFTFGYGTMPVTTPVVVVLGRRWCTTAEQHCSASTGAPPRDEDAVIRAAKWSSSNFEERLGFRVGESITEERLKRHYYILAKHYHPDTAAGSGRRGGAANHGEAGAGGEVAFHNVKEAYDVINAALKQDGRWGGTSSSSSSAPDFAGGFEYSDEARRRSQVRLLGDAVLLFMFMTVVFIIIVSGHNKSRMQSRYLWHLLWIFVMIQLFPRLLAATILFAAHSMYLLENATLKEQAAISLIVERTEKGCSVKLEGLSADAQPDVVVQVTTEVATSAATVEAVSSTLTFDKGVTAFTLPVPVDSSCVHHIKAVDEARKLVLVDRSLSGRGGCGQRSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G4P2</accession>
    <name>A0A836G4P2_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
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            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059119.1">
        <property type="nucleotide sequence ID" value="XM_067203428.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="92357362"/>
    <dbReference type="KEGG" id="loi:92357362"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="522"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="544"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5466229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="591" mass="67616" checksum="8F4032281083287C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G4Y7</accession>
    <name>A0A836G4Y7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial import inner membrane translocase subunit TIM50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_01544</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TIM50 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059284.1">
        <property type="nucleotide sequence ID" value="XM_067203593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G4Y7"/>
    <dbReference type="SMR" id="A0A836G4Y7"/>
    <dbReference type="GeneID" id="92357527"/>
    <dbReference type="KEGG" id="loi:92357527"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
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        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
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    <keyword evidence="1" id="KW-0811">Translocation</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
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            <end position="496"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
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            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
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        <source>
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    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="564" mass="61104" checksum="5FEAF572EEB1E2B5" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Leishmania orientalis</name>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG5466454.1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="4"/>
            <end position="109"/>
        </location>
    </feature>
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        <location>
            <begin position="143"/>
            <end position="238"/>
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            <begin position="262"/>
            <end position="292"/>
        </location>
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        <location>
            <begin position="152"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5466454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="388" mass="42917" checksum="04362C72C544618A" modified="2021-09-29" version="1">MLKDYYAILDVLPSASGEEIRRAFKRLALQFHPDKTGGAAAIEAAATVHTDEHSLTTSRAENLSGTAGIARLDALTTSCQPCTRGFTDIQEAYEVLGDVARRYLYDMNYQELLALKQQRQEEEQQRCEAQARAAAEAARRVRERECLRREQQQQNHQSHNTNTLPTVNSSTASAALRSTLLGPSLPQHTPLPTRGRGEEDTGVSSLPLPPNDALQKQQRRRKQESAEEMGGDCLIEDLEGGESGASRLLDDRYCFTAPTRPLKDGSRADAVQTRRQCGGRDTDGSVAAGQTQRRISCTSTKRARHRMATTVPAVFMLSGSVAFSWGDTAAKTCPSVAEHGCSRERRSHRHATLRDGDATAEPDLPLEHYYQRSIERTLRVFFGVPHLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G8C0</accession>
    <name>A0A836G8C0_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">LSCM4_04409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Trypanosomatida</taxon>
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            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067206394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G8C0"/>
    <dbReference type="GeneID" id="92360328"/>
    <dbReference type="KEGG" id="loi:92360328"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5477192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="95" mass="11524" checksum="BF3B8672094B9648" modified="2021-09-29" version="1">MLRSTCLSRGHATSNLFAPPHSGRWFNPPHQWTISDTFVPAFFLGFSPMAICVYLYHAAYMPQYSHFQEKNYYPAQVYTKEFIHKYHRLERWRWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G9J6</accession>
    <name>A0A836G9J6_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060086.1">
        <property type="nucleotide sequence ID" value="XM_067204534.1"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A836G9J6"/>
    <dbReference type="GeneID" id="92358468"/>
    <dbReference type="KEGG" id="loi:92358468"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5469109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="255" mass="26477" checksum="B71A34A9196765A7" modified="2021-09-29" version="1">MSGMDDRVKQFRAAAEAQLSGPALRKEINTLRRFLFRNQGYRFTKAAQQALYMAVIAHYGNAAAHHASGYAAASATPVTGVPSADAGNIGPSPASRVGSSRGALVPKPAGDSDDDDESGGNAADAADAPILGLLDDALKMPFTVFTSSQKDRLLTLYWAVLGTDCSAGASSGNGTTSATATRTLSLVDIVDAGNNEAQLSLFTAEGEEYPHEVLVSDAATLKRLREELHNGSAVSVTIRENDTGAALVSFSVDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GCW5</accession>
    <name>A0A836GCW5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_01956</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061032.1">
        <property type="nucleotide sequence ID" value="XM_067203995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GCW5"/>
    <dbReference type="GeneID" id="92357929"/>
    <dbReference type="KEGG" id="loi:92357929"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="287"/>
            <end position="309"/>
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        <location>
            <begin position="347"/>
            <end position="377"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="407"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="419"/>
            <end position="442"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="454"/>
            <end position="478"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="499"/>
            <end position="520"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="540"/>
            <end position="564"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="576"/>
            <end position="597"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="609"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5472636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="646" mass="72219" checksum="FCDB40C73776C66B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GDT8</accession>
    <name>A0A836GDT8_9TRYP</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">LSCM4_02999</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
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            <taxon>Eukaryota</taxon>
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            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060570.1">
        <property type="nucleotide sequence ID" value="XM_067205018.1"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A836GDT8"/>
    <dbReference type="GeneID" id="92358952"/>
    <dbReference type="KEGG" id="loi:92358952"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052109">
        <property type="entry name" value="SRRM_Domain-Containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34755:SF4">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34755">
        <property type="entry name" value="SERINE/ARGININE REPETITIVE MATRIX PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="537"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="641"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="725"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="860"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="909"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="997"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="548"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="654"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="742"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="997"/>
            <end position="1006"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5470304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1090" mass="117533" checksum="B040A7D49E6AA0AA" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GF67</accession>
    <name>A0A836GF67_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_01469</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059212.1">
        <property type="nucleotide sequence ID" value="XM_067203521.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="92357455"/>
    <dbReference type="KEGG" id="loi:92357455"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17330">
        <property type="entry name" value="MFS_SLC46_TetA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF15">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="451"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="487"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="518"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="547"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="594"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="624"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="335"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="307"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="337"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5466322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="649" mass="69482" checksum="A7B7CE595C637540" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GH22</accession>
    <name>A0A836GH22_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Vacuolar protein sorting-associated protein 54 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_00663</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058841.1">
        <property type="nucleotide sequence ID" value="XM_067202740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GH22"/>
    <dbReference type="GeneID" id="92356674"/>
    <dbReference type="KEGG" id="loi:92356674"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039745">
        <property type="entry name" value="Vps54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012501">
        <property type="entry name" value="Vps54_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07928">
        <property type="entry name" value="Vps54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 54 C-terminal" evidence="8">
        <location>
            <begin position="921"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="733"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="738"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="749"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5465210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1239" mass="134457" checksum="02C53452D7F1FD17" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GI21</accession>
    <name>A0A836GI21_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000016">
        <property type="protein sequence ID" value="KAG5482397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064403.1">
        <property type="nucleotide sequence ID" value="XM_067207589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GI21"/>
    <dbReference type="GeneID" id="92361523"/>
    <dbReference type="KEGG" id="loi:92361523"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5482397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="483" mass="51993" checksum="ED70E7CB2FE0FEB2" modified="2021-09-29" version="1">MSFAFVPQSPLAPMSHIAQQQELMRVYREELRLQQCLQEQCRLLQSLTEAAAGMLSWWREGSAAAAAGATDSDPVAGRPPTSEGPMGSNADTSESLLPSASSLLRLHSGMVFYSLGELLQLWAATAGPSDFNGDGDKGTDDNACTAETTSWGERDPSRREVHPFLCNPHRVVKCSGEHPPPWTFPASCAVPVPLINDKTGDAAHTPRTPPTTLLLPTPAQLIRYRVLDTTCPLPVTHQLLLGSVDADSFGLLLLWLMRLTKECAEALLLCRPDRHVRQAHTPSARIEGQRSSSAVNDGDGRPLQVISTPTAMENEAVKMIRTKRSRCRDEGDLRCNNGNVVSESWNALCASLIRVFSYVIAAAAAASPLADSERGQSTQQLPPSPMSCMASAATSTALRADLRLFLAEVAEVHDTVLEVEQYCGVADLQCDDSDLALKKPRGESPASAVLPPLAGQGQPMALSNMALLAHLADIVDAQVRRHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GI54</accession>
    <name>A0A836GI54_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000016">
        <property type="protein sequence ID" value="KAG5482442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064448.1">
        <property type="nucleotide sequence ID" value="XM_067207634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GI54"/>
    <dbReference type="SMR" id="A0A836GI54"/>
    <dbReference type="GeneID" id="92361568"/>
    <dbReference type="KEGG" id="loi:92361568"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="113"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5482442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="451" mass="47555" checksum="3CEB715D9F3728F3" modified="2021-09-29" version="1">MPVKEITLALPLAAEAVLDADRNIMATSAVSVLGDRALIIGTSEGSVLLCSPASEDTHILTPRCETTLHCGAIYDLAVSSHNLLATAGHDALSCILPLHTLYRDGGATRCRRITGHTVPVIAVRFLSDGTSLVTLGADGRVLVVDVRSGSVLASLLCGFAATCLACSLDETQLFVGGRSLASIDLDHTMRPTSLQSVAVAAAGPDTRASLSISTAASGDAASPRTPAWLRLYEWEDNSEVTAGASRRQFRTRSHTLIRSLCVDSGDGALTAIFARHAPRTKTVVVCGSARWAAAGGRLASQTTWSPQALRGVSAALRCHLSRGCCPGVAAEKLRVRCRMKADARPSAKQAPAQPGSFPSTSAALWNGRWYASAFELAGSTPRLTASDSLAKESFFTEGTGSQECFPLAGPRTRGEELYIAQAQCDEVQRECDALVFQIKRLLGHKAPIRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GJ46</accession>
    <name>A0A836GJ46_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Heat shock protein HslVU, ATPase subunit HslU</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_07176</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ClpX chaperone family. HslU subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000015">
        <property type="protein sequence ID" value="KAG5482967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064463.1">
        <property type="nucleotide sequence ID" value="XM_067209080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GJ46"/>
    <dbReference type="SMR" id="A0A836GJ46"/>
    <dbReference type="GeneID" id="92363014"/>
    <dbReference type="KEGG" id="loi:92363014"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009376">
        <property type="term" value="C:HslUV protease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19498">
        <property type="entry name" value="RecA-like_HslU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000220">
        <property type="entry name" value="ATP-dependent protease ATPase subunit HslU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001919">
        <property type="entry name" value="ATP-dependent protease ATPase subunit HslU1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050052">
        <property type="entry name" value="ATP-dep_Clp_protease_ClpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004491">
        <property type="entry name" value="HslU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00390">
        <property type="entry name" value="hslU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003544">
        <property type="entry name" value="PRK05201.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48102">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48102:SF3">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE ATPASE SUBUNIT HSLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="104"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Clp ATPase C-terminal" evidence="6">
        <location>
            <begin position="373"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5482967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="481" mass="53248" checksum="6D77D4943B43B8DC" modified="2021-09-29" version="1">MRRALSLPCRYSVAAASATSSHTLLTAGRCCSTAAAAAPAPAPAAPSTNPTSKTLIRDMRPRELMKELDRYIVGQSEAKKAVSVALRNRWRRHQVPSDIREEIAPKNILMIGPTGVGKTEIARRLAKLVDAPFVKVEATKFTEVGFHGRDVESIIEDLYKASLSQTKQNIRRQHEEEAKVKAEDRILKSLAGVSDGFREHLRSGALDDIEVMVELQEKKEKPKTASGEGVFISLDIPSMMGGQRQQTVKKVMKIKDAFPAVLQEELDKMMDTEDVTAEALRACEEDGIVVIDEIDKIVTAAGGYKGHQASAEGVQQDLLPLVEGTTVSTKFNVQVKTDKILFICSGAFHSVKPSDMLAELQGRLPIRVELQQLSKEDFHRIITEPRFNLIAQHKAMMATEGVDLIFEDDALWEIASIAAYINSTVQNIGARRLITITEKVVEEISFEGPERKSEKFVIDAAYVKKAVDKMVKKVDIKKFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GJ57</accession>
    <name>A0A836GJ57_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_00264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058454.1">
        <property type="nucleotide sequence ID" value="XM_067202353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GJ57"/>
    <dbReference type="GeneID" id="92356287"/>
    <dbReference type="KEGG" id="loi:92356287"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="294"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5464823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="477" mass="50778" checksum="C5258EB263FE0908" modified="2021-09-29" version="1">MPVAIMLANNTDCPKSTQQQRLEDSKSLCALSPECISHREQTEERTTNDGGAHRLEWSPQTPETLPVRVADLRVTAVAGTSATETAYETASNACLNVEGLTEGVAAAGGSALAAVPQRAPERGSSASSVRKSLYDASDAVSSSSRHVDALGGLTVSAGQRKPPSSLTRSTGSGNTLRNVVAAAHVDETLPPPLRGVFFPSAVCDAATTASLVTLISSYCDVITLVQLMRVDRSAHLLATSDEVWKPILASMNLPPLLSAYERDRDYYDFFLKDVITTRALHGHYTFQAADATPGSRGSVSTTSGSRSVGLNRDRASRDEDSFQEDIFNVASLQLLISAASLGQSNHRIGRVQLLLTYKNESMEVLQGACRFSVHRRCFSLCCSAFGTVKRGPVFTVAVATVTKPWANEGFQHFSEHKNGIRLVMTPVLWEGQSPGSQITEKDILVVSRPKPVLASATLAAGSTSASSSLNTPTASHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GJ77</accession>
    <name>A0A836GJ77_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_00297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058484.1">
        <property type="nucleotide sequence ID" value="XM_067202383.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92356317"/>
    <dbReference type="KEGG" id="loi:92356317"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1354"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2545"/>
            <end position="2593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5464853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="2695" mass="293480" checksum="771FD2C0ED6E60F3" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GJ95</accession>
    <name>A0A836GJ95_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SMP-LTD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061855.1">
        <property type="nucleotide sequence ID" value="XM_067205918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GJ95"/>
    <dbReference type="GeneID" id="92359852"/>
    <dbReference type="KEGG" id="loi:92359852"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="414"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5474749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="629" mass="63278" checksum="4C70A3463FAE88D4" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GJF5</accession>
    <name>A0A836GJF5_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_04016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061945.1">
        <property type="nucleotide sequence ID" value="XM_067206008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GJF5"/>
    <dbReference type="GeneID" id="92359942"/>
    <dbReference type="KEGG" id="loi:92359942"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5474839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="510" mass="53534" checksum="A92D0AA8A6A3BF4F" modified="2021-09-29" version="1">MDPVQELIAAVGQADMEGGRRRTQASLLSSSAALDVSSACASAAPPRRTKMVFVYSDEDDGEDDGVEGHGAMRPESGVTEVLCDDHAIAVSADALAELQAEAANAAVGTADAQTSLFDASGDGNGFLFEEDVVSGLAGGASGPSATFGGMRMREVAAPRLWEGAVAPAASSDFRGGGADDPLSATDEAHPFLRRGLPAADFVLRSRRKRFREIPVADGDPAQSSAKNAAATTTAGESVQESPAAAAEPSLHDPHLSSELFPGHPQGAQNSDGSLLDDASDSLEAAVEEEPDVYPVYADDGRTVRALRTRGGYELTLDERDLLECVAEEEEKDARDGHAEQNDGAAAAGAEEGKAADDGDHDAHVDDVLSGPMAGQLASSAAAAAAEDGDEVAGTDLPEQAEADEWGDFDDFDDEEDEEEAELDEAIIVAVVEQLVCCCKADDLDPQMAVEAARFVGTAKPLLEQLTNEMITPAEFVQRIDRDLRRFQRIYKAVYRPRDSPIVIDGVTTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GLX9</accession>
    <name>A0A836GLX9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Leucine-rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_08004</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000013">
        <property type="protein sequence ID" value="KAG5484437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064930.1">
        <property type="nucleotide sequence ID" value="XM_067209880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GLX9"/>
    <dbReference type="SMR" id="A0A836GLX9"/>
    <dbReference type="GeneID" id="92363814"/>
    <dbReference type="KEGG" id="loi:92363814"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050836">
        <property type="entry name" value="SDS22/Internalin_LRR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652:SF7">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5484437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="458" mass="49376" checksum="F3964AACE01943A2" modified="2021-09-29" version="1">MEIWTTELQRAHAQLLADDTYRSSVMKPQRLLGHLQGDALLEVLKFAPGNLLLTLAAVSPKARLLAELLESRLSTNLRLILDDATVMHELVTEAAGTPLVQPLDTVAWWINKCGISVSIRGDEMAFKLLGSSRLRPIVRSVSLSHLVRACPIPVDVALHLERIDMCGEAFSSLLAHPCQMTQLRELHVMRCTSAALARLSQLPSITMLSIESKMAVAPLDNANAAEIPQQSLNGVGVIDMRLWAFVRTLQHLRLSGSDLSVVTGFDCCESLSTFTAVNCQRLLSLSSLGLAVHLRTLSVSWCGVRDLGRLAACVCLQRVSFDTCGALESLAALAGAPRLREVDVFCSAVRDVQGLASCPCLETLRVTACRLLTDLSPLAGAPRLRIIDASFSAVSNLQGLGTCPCLEVLRLDMCPAVEDLHPLAGAPRLRYVFVNGLNHAALSYPSSLASRILPAPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GP59</accession>
    <name>A0A836GP59_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_02583</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060162.1">
        <property type="nucleotide sequence ID" value="XM_067204610.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836GP59"/>
    <dbReference type="GeneID" id="92358544"/>
    <dbReference type="KEGG" id="loi:92358544"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:005620">
        <property type="entry name" value="Putative Unc104-like kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="6">
        <location>
            <begin position="38"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="519"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="577"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="923"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1676"/>
            <end position="1703"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="477"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="615"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="550"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="930"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="957"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1676"/>
            <end position="1687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1688"/>
            <end position="1698"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="139"/>
            <end position="146"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5469185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="2077" mass="222954" checksum="40D86719E17F561A" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GSZ3</accession>
    <name>A0A836GSZ3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_04682</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000023">
        <property type="protein sequence ID" value="KAG5478449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063110.1">
        <property type="nucleotide sequence ID" value="XM_067206663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GSZ3"/>
    <dbReference type="SMR" id="A0A836GSZ3"/>
    <dbReference type="GeneID" id="92360597"/>
    <dbReference type="KEGG" id="loi:92360597"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000134">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115:SF601">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115">
        <property type="entry name" value="KINESIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3 4" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="7">
        <location>
            <begin position="93"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="517"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="612"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="21"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="199"/>
            <end position="206"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5478449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="766" mass="87393" checksum="BAE2B7376E4ED66F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GT60</accession>
    <name>A0A836GT60_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_04802</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="JAFHLR010000023">
        <property type="protein sequence ID" value="KAG5478569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063230.1">
        <property type="nucleotide sequence ID" value="XM_067206783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GT60"/>
    <dbReference type="SMR" id="A0A836GT60"/>
    <dbReference type="GeneID" id="92360717"/>
    <dbReference type="KEGG" id="loi:92360717"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045191">
        <property type="entry name" value="MBR1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024766">
        <property type="entry name" value="Znf_RING_H2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22937:SF65">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ARK2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22937">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12678">
        <property type="entry name" value="zf-rbx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="327"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="225"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5478569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="408" mass="43593" checksum="91DC8AFE03B575A8" modified="2021-09-29" version="1">MPKRGRANSTDASYAAEHGVVEVSDADSRTTQPISVEEMTESPLDLALEQQLDALEVDEDFRESIRAMTPNTRRDVLNDIIRHQQHAEIEEGLMRGFSVGDIGSAGSLFTFSAGMPPGMHQVHMMGGSRAHNDAEDYADMTGDAEEDEEEGEVRGSYRQAVIEEDEEAETEFAVEMPPFLLRGMAMGSGGNTGMPRVQRPGGRPPQQAGGPPTVLDILRLIAGQNAAQARGGGGGDGSDGFQRQSRGTGQRTSFEEGMMNLHNLIGVLQQANVMQSMGLDHDIDDMTYEELLELEERIGNVSKGVPPALLDGCTMPMRSTSAEAGTCAICQEELSIAFATATAGAASTATSPSGADKVCVRLLNCPHAFHKPCINQWLTQNKTCPICKVEVLPKPASSSSSPRSAPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Trypanosomatida</taxon>
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            <taxon>Leishmania</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="92359144"/>
    <dbReference type="KEGG" id="loi:92359144"/>
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        <property type="component" value="Chromosome 31"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5471645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="94" mass="10371" checksum="432F6A7B3F1C53DE" modified="2021-09-29" version="1">MDGLHSSGRLTFHDSVRVNIFGPKNEVTSAVIDFCVVAKQLRPYPRSATEAPVRLTNTSRLVCENSIAFGRILACVLRWTGWCSSFITNGEVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GTN5</accession>
    <name>A0A836GTN5_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067205225.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="92359159"/>
    <dbReference type="KEGG" id="loi:92359159"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
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            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="844"/>
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        <location>
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            <end position="1236"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5471660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GUQ8</accession>
    <name>A0A836GUQ8_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">LSCM4_00582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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            <end position="31"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5465130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="425" mass="47552" checksum="1766B5FE59352EC4" modified="2021-09-29" version="1">MVGPLPLHPAAARAVAALLLLPLALPHVAYGWSGADAYTIVLLNDFDTDLALQDQFYNAPVGAILSVARGGYRLMEEGVAQSTFAPTSATTKGASASARETAPMSVYALDNRLSTAMAYQGMKAVDAALPFRCRLSGEWVVWSKEQPRRKDADAEPILLHCRLPLPQNRTEIALQQRRYIARNRAAMSAALEAWWHTAASEQASRCLYGDGEKALTGTERYYELCPAGAVYRVQHERLKRLLQRPSQPRRTEGDATRRKGAPSVLDFLHMMHRSSSSRHAVLQNSRFDGIFEKIGEYHSLLSKPRWNTEYLVWESWYPSTNPCNTHYTTLSNFSGSGVRDTSITARVPGAPRAVRPQDAYWKTVVRFRCPSRRAAQETARTSLWTVTEVRQLCEYYVEVLSDLVCGWEQELDSFQVNPVPCVVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GUY8</accession>
    <name>A0A836GUY8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PIPK domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_00033</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058224.1">
        <property type="nucleotide sequence ID" value="XM_067202123.1"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A836GUY8"/>
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    <dbReference type="KEGG" id="loi:92356057"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016308">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4/5-P-5/4-kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086:SF144">
        <property type="entry name" value="5-KINASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIPK" evidence="2">
        <location>
            <begin position="28"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5464593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="456" mass="51220" checksum="7C27256946F8BD1A" modified="2021-09-29" version="1">MGQVGGAATSGRGLTALQVAAALRVTVAAQLKRSEAAASAPLTVRRTLSGLAAHSSTFAPEDFSAQQQLTVLSTDSKGKQVKVHVTEYAPNVFFFLRQVEGVADSQFAEEWSLPEDRLKMEMGEGRSQALFLKSKTMSFMCKTIAVEEVHVLLRVLHDYAQHIATHPSTLLMRFYMLLKVSVLKEEGYILCFNDVFGAASVLHEKWDIKGRIPKPGKYQHYPHLIRRAYEPEPFLIETPKSLDLLVQPVTGSSQQRHDREDAFVVRGVEDAQRLPTLHDKDLTRLFWLPHLTRKRLVEQLLSDYDFLSNAGLMDYSLLIGVAYQENKMSRSGKRYIIENMRMSAPPGVASASPRAELRPASLAQGIPGSDKSTRMVTLPEFANGIHSLNDQEIYYVGIIDMLTTYTIKKKSANFFKSFLWEQKTLSTIPPGRYARRITAFTQFIFPDVVEGRPHVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GUZ7</accession>
    <name>A0A836GUZ7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_00048</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058239.1">
        <property type="nucleotide sequence ID" value="XM_067202138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GUZ7"/>
    <dbReference type="SMR" id="A0A836GUZ7"/>
    <dbReference type="GeneID" id="92356072"/>
    <dbReference type="KEGG" id="loi:92356072"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002167">
        <property type="entry name" value="GDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00928">
        <property type="entry name" value="GRAVESDC"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="308"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="552"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="610"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="643"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="145"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="250"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="351"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="549"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5464608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="755" mass="82667" checksum="1BF255A7034C88CC" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GV89</accession>
    <name>A0A836GV89_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Leucine-rich repeat protein (LRRP)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_05746</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063450.1">
        <property type="nucleotide sequence ID" value="XM_067207677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GV89"/>
    <dbReference type="SMR" id="A0A836GV89"/>
    <dbReference type="GeneID" id="92361611"/>
    <dbReference type="KEGG" id="loi:92361611"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5479739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="745" mass="80653" checksum="7FE3B659E2BD794F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GVW5</accession>
    <name>A0A836GVW5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_05534</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000016">
        <property type="protein sequence ID" value="KAG5482281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064287.1">
        <property type="nucleotide sequence ID" value="XM_067207473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GVW5"/>
    <dbReference type="SMR" id="A0A836GVW5"/>
    <dbReference type="GeneID" id="92361407"/>
    <dbReference type="KEGG" id="loi:92361407"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000037">
        <property type="entry name" value="Phytanoyl-CoA_dioxygenase_(PhyH)/2OG-Fe(II )_oxygenase_superfamily_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF246">
        <property type="entry name" value="TRANSMEMBRANE PROLYL 4-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="148"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5482281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="317" mass="35672" checksum="946E71A9E963DAC5" modified="2021-09-29" version="1">MFSYNNIVEKGEPREKEIIDHVFDHVTQFPTPTVIPIGDGKVDCIVLENFLTHEECDQLMAASEKVGYTFWLQRNHHDADGEATCDSASKAVRVVDTIEANFPHLSAKLYERISRVVSLEPKCFSEAMPNADELFERDLVGTWVPHALSENLLFGRYHVGGHFMPHVDGSNILDLNTRSFYTLLIYLNDCSLGGETYIFAGEQCNVMYLDAQENQYRGNAAQRVGAVCPKKGSAAFFNYNLLHEGAPVMQGYKYICRADVLYHRTPPILTSEADVKAFSVYQEARLAESQGDAERACQLFQRVRKLSKGVAAIFQID</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GWH2</accession>
    <name>A0A836GWH2_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000020">
        <property type="protein sequence ID" value="KAG5480414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063745.1">
        <property type="nucleotide sequence ID" value="XM_067208105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GWH2"/>
    <dbReference type="GeneID" id="92362039"/>
    <dbReference type="KEGG" id="loi:92362039"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="540"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="585"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="738"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="920"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="981"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="590"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="738"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="788"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="932"/>
            <end position="947"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5480414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1038" mass="109050" checksum="247A66A1C922C002" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GXF3</accession>
    <name>A0A836GXF3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Succinate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_07275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000015">
        <property type="protein sequence ID" value="KAG5483061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064557.1">
        <property type="nucleotide sequence ID" value="XM_067209174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GXF3"/>
    <dbReference type="SMR" id="A0A836GXF3"/>
    <dbReference type="GeneID" id="92363108"/>
    <dbReference type="KEGG" id="loi:92363108"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1060.10:FF:000017">
        <property type="entry name" value="Putative succinate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050573">
        <property type="entry name" value="SDH/FRD_Iron-Sulfur"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921:SF45">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE IRON-SULFUR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13534">
        <property type="entry name" value="Fer4_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5483061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="184" mass="21183" checksum="BF2B576E005028D6" modified="2021-09-29" version="1">MPSAPLPGQLANYSSPLYMYRHLVKNSTTKTPQLYTAKDNSKTTMHLLTRRPPNANYTVNRWYLKEKVDSSNRMRLEGLYECVLCASCTGSCPQYWWNREHFLGPAVLLQSYRWLVEPLDRDFDERVRMFETGNLVNMCHNIYNCSITCPKFLNPGLASKEIKRLSSPSTKRVGPAAELKSIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GXP7</accession>
    <name>A0A836GXP7_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LSCM4_03215</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">LSCM4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060780.1">
        <property type="nucleotide sequence ID" value="XM_067205228.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92359162"/>
    <dbReference type="KEGG" id="loi:92359162"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000082">
        <property type="entry name" value="ABC transporter, multidrug resistance associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000630">
        <property type="entry name" value="ATP-binding cassette (ABC) transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002055">
        <property type="entry name" value="ATP-binding cassette protein subfamily C, member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000010">
        <property type="entry name" value="Multidrug resistance-associated ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
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</entry>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
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                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
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            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
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        </reaction>
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    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CSA_PPIASE_2"/>
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        <source>
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        </source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="354" mass="38327" checksum="81E9B6DE3880036B" modified="2021-09-29" version="1">MPNTYCYFDITIGGKPKKERVIFELFADVTPKTCENFRQLCLGNDGKKVAGTEVPMTYQGCTFHRVIPGFMIQGGDFTNHNGTGGVSIYGEKFEDENFTIPCDKSGLLAMANAGANTNGSQFFITTAPATHLTGRHVVFGRVVRGMNTVRAIEHTSTGANDKPVLDCVIAGCGALDAVPDVMPAADGDMYPDYPEDTESPMDDALRIEAGEAIRQNGNGHFKNADYDSAMDKYSKAVRYLNQVENKDGHPEADEKLVACYNNIAMCAIKLQQWSEARHAASLALSVDAKNAKALFRRGTAALSAGDADSAVEDLTQANHIEPENAEVIAKLNEAKEKVKAQKAKLAANLKKMFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
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    <sequence length="276" mass="30009" checksum="6F21F9C14EAB927A" modified="2021-09-29" version="1">MSLRPFAGARGRALVLRVPWTVRHGASTARGACLSRRTCSPYLAIFHPLIASAVTMHASPLTAPRRAQSSLQRLLNDSKDPYLAALQQFDIPRIADIVEEGPAPSGVPASFLRRAGIRVDTDAITAAQAQPVPSTPLAQRPVQSSGEAVLQSLHAVGAKHRSETEAAAAAELKSAQEAYDALPQERKAALQMERVVSHLFDGLCAMSAAMRMQAEEGAVSVEERDAAFRVYKRIVSAYRDGIIAVDRWGTDFVPELEELRVIWQHLSDARAMPLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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        <name evidence="2" type="ORF">LSCM4_06993</name>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
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                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <source>
            <dbReference type="EMBL" id="KAG5481914.1"/>
        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000674143"/>
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    </evidence>
    <sequence length="217" mass="23809" checksum="99F75CFADB340CD3" modified="2021-09-29" version="1">MRGKQCGTSGLDAGTPQRPEDVFGRLSQRLPTSLSSSAFDAVAAHQQQEASQCTFLPRVNHTHDAALIRWAAGSDVFTRLYGHARCQQQRREDAAEAKRKADAAEVDEWHTRFRQVSFPKHLYAHAQRKEDHATDSAAARIATPKRGTQIISALHTDRRSAHSTVTDPRTRPNDSGPSAAVHGAAALSVARAEVWLSRMRTAYLSRVPPRSLRGGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836H050_9TRYP</name>
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            <fullName evidence="2">ADF-H domain-containing protein</fullName>
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        <name evidence="3" type="ORF">LSCM4_02173</name>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
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                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_067204207.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5472848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="415" mass="46289" checksum="3B6C520C6992485A" modified="2021-09-29" version="1">MPKVVCLWRGSDEIDNAIEHLDEAKVQLLYSKFPVGSGTFKRNKFIYVQYIGPKCGIVKRGQGINEITNFTTNNIRGVPGFSTTDKASLSFEFLVRHMRDTFVTDSGDFSMEQIREEYRERLAAEQKMMHQGREQAAVVAATAKRARRNTAPSVRVAPKTAPPPAPAPAPAPKEEPPLSPVQVSEQTNHVMASLRQDNGSVNWAVFESHPQTLMVRAYGRQGIFEMVKNLPDDAWLFGLFRISFSDGEAHQRRIIFFQWIGSNLKAVRGDGHAGVYPAMAKALFPFHYEIYLVGRQDLNPKAIIAKSKSAFRTPEDRRSGVARDLMMDSTVFTEENYRQSLVHEQAHAEALEERPKKVHRLTMPIIADGMEQSAAALGPASTANSPAAQSFSIPETIDLVQANEGGLMWAIFEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H121</accession>
    <name>A0A836H121_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin carboxyl-terminal hydrolase</fullName>
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        </recommendedName>
    </protein>
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        <name evidence="10" type="ORF">LSCM4_04202</name>
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        <name type="scientific">Leishmania orientalis</name>
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    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="7"/>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062128.1">
        <property type="nucleotide sequence ID" value="XM_067206191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H121"/>
    <dbReference type="SMR" id="A0A836H121"/>
    <dbReference type="GeneID" id="92360125"/>
    <dbReference type="KEGG" id="loi:92360125"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF24">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="247"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="179"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5475620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="575" mass="65171" checksum="85F74B715E709140" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H1N1</accession>
    <name>A0A836H1N1_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061571.1">
        <property type="nucleotide sequence ID" value="XM_067205634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H1N1"/>
    <dbReference type="GeneID" id="92359568"/>
    <dbReference type="KEGG" id="loi:92359568"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5473568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="465" mass="50383" checksum="E6E9EC0B9372F935" modified="2021-09-29" version="1">MRLATAQLYKSNALFRVLAFLDNTGAQAFALDTEVDEDGDFRNADSVFGADAAITGILTAALDALRANVRRLFTDAAEQHALLAVLGAGAPDPSTRASLWITTAPAPLPLEGDGAAAVGVNADGPLERLHSSSSAPMGTPWSEAVLHPTSLAHYADIVENEIPIHLLMRLRDVLGIPTATLAGDSAVPVAASCCCSCSPFVEQFLIDGLDEWLRRCPIDEVKRMIRACGVQPVVLESAFTQQQQSDAQGSSLPNALADFVVDVVFPVPAHAGKASVDASSGAAVEGLQDWLILSYEKNREAVDIEEEESTSTNEQSDRSDSGATNSQRERKRHRADIARPAADRGDSLGSWEPEDGEEVLTAENIDRYLLECPNRIPKEILREKRKRISDASITEFELERHFTAAELKQLVKERLGAMTASEATEFMKCPVTEAQVQQAARLTRKAQFVAWILSLHASVQQQSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H1V2</accession>
    <name>A0A836H1V2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">adenine phosphoribosyltransferase</fullName>
            <ecNumber evidence="6">2.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_04996</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="6"/>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062273.1">
        <property type="nucleotide sequence ID" value="XM_067206970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H1V2"/>
    <dbReference type="SMR" id="A0A836H1V2"/>
    <dbReference type="GeneID" id="92360904"/>
    <dbReference type="KEGG" id="loi:92360904"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050120">
        <property type="entry name" value="Adenine_PRTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11776">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11776:SF7">
        <property type="entry name" value="PHOSPHORIBOSYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="11">
        <location>
            <begin position="45"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5476040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="237" mass="26200" checksum="E1EC6734B6C54341" modified="2021-09-29" version="1">MSLREVAPHTYLLEESHQLSQLLKKNYRWYSPVFSPRDVPRFADVSSITESPETMKAIRDFLVERYRAMTPAPTHILGFDARGFLFGPMIAVELRIPFVLMRKADKNAGLLIRSEPYEKEYKEAAPEVMTIRYGSIGEGSRVVLIDDVLATGGTALSGLQLVVASAAEVVEMVSILSIPFLKAVERIHSTANGRYKDVQFLSLLSEDALTAENCGDLQGVDGPRVISCGDLLAKNLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H1Y5</accession>
    <name>A0A836H1Y5_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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            <begin position="307"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5476085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="332" mass="38451" checksum="676E8008A4FD24A6" modified="2021-09-29" version="1">MTSTSGPASTEEVALASLSNYSPGQLQMAEVALRAVLMEKVQALATEHGEAFIQSLLQKEISRTKKMEAELANMKKKLGVQERVVDDVRMDVRKTKAQEEKSKYICQSLQEAAKKREQLTEKMQPEMETYRSDVRERVNQNVQNIWAECEVRRERVEAIEAEVKELETTLAHKKEVFEQSFAEFQAGLKGRTTQYQELIISYEEAAKEVELLEARLMLVRRERNSVEMARVSLQEQLEVYEKQFEGFAKSVMKPEDVEALAQRQRDQAQMRITELEADKANVHQQRLQMDKELTELRAKHASLKREMQQLEKAKAAAEKKCRQAQQSRQERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H5Q2</accession>
    <name>A0A836H5Q2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">NADH:ubiquinone oxidoreductase-like 20kDa subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_04145</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the complex I 20 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000027">
        <property type="protein sequence ID" value="KAG5475563.1"/>
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    <dbReference type="Proteomes" id="UP000674143">
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    </dbReference>
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        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HydA/Nqo6-like"/>
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    </dbReference>
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    <keyword evidence="10" id="KW-0520">NAD</keyword>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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        <location>
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        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009173"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU004464"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5475563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="201" mass="22850" checksum="C40AD1D9BE6647D1" modified="2021-09-29" version="1">MLRFTRASLTGRAMISRGSPEWSHRLDLKKGKKTTLAHKLGTSKPNNALQYAQMTLHDLTEWVLAYSPWPLTFGLACCAVEMMHSYSSRYDLDRFGIVPRPSPRQAEIIIVSGTVTNKMAPLLRNIYVQMVNPKWVISMGSCANGGGYYHFSYAVLRGCERSIPVDFWIPGCPPSAESLVFCLHNLQKKIRWHEIQKYSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H771</accession>
    <name>A0A836H771_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05264</name>
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    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Leishmania</taxon>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062516.1">
        <property type="nucleotide sequence ID" value="XM_067207213.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="92361147"/>
    <dbReference type="KEGG" id="loi:92361147"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5476283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="86" mass="9777" checksum="BC4C4E4644254889" modified="2021-09-29" version="1">MPPRTSALAYEDEPYWIMCLREYLIPGVVFTVMFYYLSVHVLMPMRRIYRPTRRTPEVLAGAEDGGEAASSENLVAPAKAKLKRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H775</accession>
    <name>A0A836H775_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DEAD/DEAH box helicase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_06776</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000009">
        <property type="protein sequence ID" value="KAG5486069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067208689.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="loi:92362623"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
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        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
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        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="11">
        <location>
            <begin position="113"/>
            <end position="141"/>
        </location>
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    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="144"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="497"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="431"/>
            <end position="462"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="757"/>
            <end position="776"/>
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    <feature type="short sequence motif" description="Q motif" evidence="7">
        <location>
            <begin position="113"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="447"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5486069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="776" mass="87142" checksum="B67E7B8D18083D34" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H989</accession>
    <name>A0A836H989_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein SDA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_06986</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Required for 60S pre-ribosomal subunits export to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SDA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG5481907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
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    </dbReference>
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        <property type="entry name" value="SDA1_N"/>
    </dbReference>
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        <property type="entry name" value="HSDA/SDA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN SDA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SDA1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
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    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
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            <begin position="58"/>
            <end position="433"/>
        </location>
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        </location>
    </feature>
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        <location>
            <begin position="546"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
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            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="706"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="753"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="788"/>
            <end position="813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5481907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="878" mass="98822" checksum="EF0C679303E0A8EE" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HA45</accession>
    <name>A0A836HA45_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_02243</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061314.1">
        <property type="nucleotide sequence ID" value="XM_067204277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HA45"/>
    <dbReference type="SMR" id="A0A836HA45"/>
    <dbReference type="GeneID" id="92358211"/>
    <dbReference type="KEGG" id="loi:92358211"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5472918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="315" mass="35088" checksum="C95FBFB7C96D2D27" modified="2021-09-29" version="1">MRGQERIWKAAPLPQSFHASLEAGNWLRALQIYQRHPYHTPPADTFDLLKAVMHFTGVGVEDVKARFNEKLRLSASLQRRKSEEVEWSLFWEALNKGDGKMISAALSGAALSGATQQIGMAEACAVLLKGAGTEWHTRLVDDLPFSTVSRCSLLHAALSEKRPDVAAEMLSHARVTRSDMNSLWPLMAQCTWEEVLRMISACPKNAVPYNKALPFILKDGCSLQTLSEHLEHARVLGDADVVAPLLAYAVEMGDWSYVERCVGHLVDIGKITPSARDAFGHLCKSHGPKRVCQRLLEHHVELCDITIEDLESLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HBM1</accession>
    <name>A0A836HBM1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein arginine methyltransferase NDUFAF7</fullName>
            <ecNumber evidence="7">2.1.1.320</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_04721</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48108"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:88221"/>
            <dbReference type="EC" id="2.1.1.320"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NDUFAF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.320" evidence="7"/>
    <dbReference type="EMBL" id="JAFHLR010000023">
        <property type="protein sequence ID" value="KAG5478488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063149.1">
        <property type="nucleotide sequence ID" value="XM_067206702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HBM1"/>
    <dbReference type="SMR" id="A0A836HBM1"/>
    <dbReference type="GeneID" id="92360636"/>
    <dbReference type="KEGG" id="loi:92360636"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035243">
        <property type="term" value="F:protein-arginine omega-N symmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12710:FF:000005">
        <property type="entry name" value="Protein arginine methyltransferase NDUFAF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049:SF7">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5478488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="472" mass="53234" checksum="6B9DA5BE80694A7D" modified="2021-09-29" version="1">MQQRLVRTSSAAAAASVLGGSSTTVGPSSSASSTGAAFIMRLHRTGLFSTTPARLAMNLHASDLSTPDRATVNSASKKEFKTALCSELVNKIIAQGYYPMSQFIKDCLTHPQYGYYASKKNVIGNEKADFITAAEIPFFGDVLAAWLMDAWQKMGTPRVLHLVEMGPGRGTLMKTMLKQIQYSNPHLLHFLQIHLVEVGAARREEQKRALAEFQTAQGKIKWWMDLESLPFSLEPTVFIANEYFDALPVAQFRYTERGWVETCVEVDTDPGTEAHFRLVHAPSGSMSAYLIPDDIRTKGRNGDCVEVNTVGMQTMETLMKKMIDCQKAACLLVDYGKDDHMHSTLRGIRGHRFVDPLLSPGEVDLSCWVSFRQLRWALERLEVARRHLKWFPVMTQRDFLLENGIDIRLAHVIKDEETRTALKALQNYRRLMDKEEMGESYKVFAFQTRNFPNVSPFFAEMAVPPLPQGRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HDA3</accession>
    <name>A0A836HDA3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Replication protein A subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LSCM4_03936</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the heterotrimeric canonical replication protein A complex (RPA).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the replication factor A protein 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061866.1">
        <property type="nucleotide sequence ID" value="XM_067205929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HDA3"/>
    <dbReference type="SMR" id="A0A836HDA3"/>
    <dbReference type="GeneID" id="92359863"/>
    <dbReference type="KEGG" id="loi:92359863"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04474">
        <property type="entry name" value="RPA1_DBD_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04475">
        <property type="entry name" value="RPA1_DBD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04476">
        <property type="entry name" value="RPA1_DBD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000041">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000064">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000344">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047192">
        <property type="entry name" value="Euk_RPA1_DBD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013955">
        <property type="entry name" value="Rep_factor-A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031657">
        <property type="entry name" value="REPA_OB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004591">
        <property type="entry name" value="Rfa1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00617">
        <property type="entry name" value="rpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165:SF4">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08646">
        <property type="entry name" value="Rep_fac-A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16900">
        <property type="entry name" value="REPA_OB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="OB" evidence="10">
        <location>
            <begin position="23"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Replication protein A OB" evidence="12">
        <location>
            <begin position="135"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Replication factor A C-terminal" evidence="11">
        <location>
            <begin position="293"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG5474760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="467" mass="52303" checksum="41C8FA48A54FAA3D" modified="2021-09-29" version="1">MQQPGSHQIQPIDSLTPFLGGKWWIRARVTDKTDIRTWNKPTSQGKLFSFTLIDESAAIRATVFNDAVDTFEPLIVNGQVYYFSGGQVKNANRRFSNVNNDYELTFDRSSEIMLARQDTSTAALPMQRYNFVPIELLKQREVGSLVDVLGVVLKVDEVSSITQKSTGRELVKRNVKMGDMTAAVEVTFWNDEAKAWGYPVGTVVALRQLKVGSFDGVTLSSTYQTKIDVNPTDLPDVKKLATWYVSTGGANVTSLSSQGLGAAGGAGGESDRGRKYLDEIQSEGIGRGLKPEYVDVRCVPIYFKQDAQWYDACPTCNKKVTEEGAQGDRFRCEKCDKTVTPTQRYLVSIQVTDNVSQAWLTLFNEAGIEFFGMEAAELKRRAQEDPLYIAKLAQGRMNRPVVMRLRVKEETNSNAITGEESDRLRMSVVRISEFMPIAGTSEETRRRLAQNLRTECDEILRLIEAYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HEG7</accession>
    <name>A0A836HEG7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LSCM4_05891</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063594.1">
        <property type="nucleotide sequence ID" value="XM_067207821.1"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A836HEG7"/>
    <dbReference type="GeneID" id="92361755"/>
    <dbReference type="KEGG" id="loi:92361755"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="DEADc_DDX39"/>
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    </dbReference>
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        <property type="entry name" value="SF2_C_DEAD"/>
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    </dbReference>
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        <property type="entry name" value="ATP-dependent DEAD/H RNA helicase"/>
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    </dbReference>
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        <property type="entry name" value="ATP-dependent RNA helicase SUB2"/>
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    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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    </dbReference>
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        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
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    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="12">
        <location>
            <begin position="127"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="158"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="363"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="8">
        <location>
            <begin position="127"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG5479883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="526" mass="59703" checksum="0892B02CB33CB34C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HG02</accession>
    <name>A0A836HG02_9TRYP</name>
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        <recommendedName>
            <fullName evidence="2">ApaG domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">LSCM4_05039</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000026">
        <property type="protein sequence ID" value="KAG5476083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062316.1">
        <property type="nucleotide sequence ID" value="XM_067207013.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="92360947"/>
    <dbReference type="KEGG" id="loi:92360947"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1470">
        <property type="entry name" value="ApaG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ApaG_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036767">
        <property type="entry name" value="ApaG_sf"/>
    </dbReference>
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        <property type="entry name" value="F-BOX ONLY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14289:SF16">
        <property type="entry name" value="POLYMERASE DELTA-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110069">
        <property type="entry name" value="ApaG-like"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51087">
        <property type="entry name" value="APAG"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="403"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="372"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5476083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="603" mass="64496" checksum="02231C3DDBF5D171" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HH13</accession>
    <name>A0A836HH13_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Prolyl endopeptidase</fullName>
            <ecNumber evidence="7">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_06769</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Serine peptidase whose precise substrate specificity remains unclear. Does not cleave peptides after a arginine or lysine residue. Regulates trans-Golgi network morphology and sorting by regulating the membrane binding of the AP-1 complex. May play a role in the regulation of synaptic vesicle exocytosis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of Pro-|-Xaa &gt;&gt; Ala-|-Xaa in oligopeptides.</text>
            <dbReference type="EC" id="3.4.21.26"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase S9A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="7"/>
    <dbReference type="EMBL" id="JAFHLR010000009">
        <property type="protein sequence ID" value="KAG5486062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065393.1">
        <property type="nucleotide sequence ID" value="XM_067208682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HH13"/>
    <dbReference type="SMR" id="A0A836HH13"/>
    <dbReference type="GeneID" id="92362616"/>
    <dbReference type="KEGG" id="loi:92362616"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000005">
        <property type="entry name" value="Prolyl endopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.120">
        <property type="entry name" value="Prolyl oligopeptidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002471">
        <property type="entry name" value="Pept_S9_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023302">
        <property type="entry name" value="Pept_S9A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002470">
        <property type="entry name" value="Peptidase_S9A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051543">
        <property type="entry name" value="Serine_Peptidase_S9A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11757:SF19">
        <property type="entry name" value="PROLYL ENDOPEPTIDASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11757">
        <property type="entry name" value="PROTEASE FAMILY S9A OLIGOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02897">
        <property type="entry name" value="Peptidase_S9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00862">
        <property type="entry name" value="PROLIGOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50993">
        <property type="entry name" value="Peptidase/esterase 'gauge' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00708">
        <property type="entry name" value="PRO_ENDOPEP_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S9A N-terminal" evidence="10">
        <location>
            <begin position="30"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="9">
        <location>
            <begin position="511"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5486062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="731" mass="82989" checksum="4408917F5F617652" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HHK2</accession>
    <name>A0A836HHK2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_07125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000018">
        <property type="protein sequence ID" value="KAG5481413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064092.1">
        <property type="nucleotide sequence ID" value="XM_067209029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HHK2"/>
    <dbReference type="GeneID" id="92362963"/>
    <dbReference type="KEGG" id="loi:92362963"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1410.10:FF:000021">
        <property type="entry name" value="SET_domain_containing_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="367"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5481413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="626" mass="66722" checksum="D670223B32DD11EA" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HIC5</accession>
    <name>A0A836HIC5_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_04604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062796.1">
        <property type="nucleotide sequence ID" value="XM_067206587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HIC5"/>
    <dbReference type="GeneID" id="92360521"/>
    <dbReference type="KEGG" id="loi:92360521"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5477385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="261" mass="30528" checksum="6F135C0BE682F423" modified="2021-09-29" version="1">MAELFSKKSWRLKDVLFNQGAEQVVRVLKIDHPFRRQRITIVPTPRYAREAYLTDWVYQPYVREHTMYVSNDIYNPFYVFLCRMLLRKGRFPEYAYFHPMGLPDCVDVNLSRRAFIKKEQPFKTPMSTILMTTNHFRDSHHPWVSRRVLKIVGEQYVVHPKEDRQSMVFLLPPAYVPEVVNTLQGLGFAVTDTVTAPIGEVALIKKLNRWSNACQLLVLGYLWLLLALFIAGESRHIHDLFQDYKRGLIEKAGKDPAKMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HKM8</accession>
    <name>A0A836HKM8_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_05717</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063422.1">
        <property type="nucleotide sequence ID" value="XM_067207649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HKM8"/>
    <dbReference type="GeneID" id="92361583"/>
    <dbReference type="KEGG" id="loi:92361583"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5479711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="352" mass="38607" checksum="389748DC8BCA21DF" modified="2021-09-29" version="1">MAVSTTTQKAGGGSSKPCEGRLHLVYAAHQRLEDELSTFLAFAAAAKKHDTNPASALEGFSPWTGVMESAAKCADATSRCLRLFNPSRKISQFKGMNALAKLYGTSAAPHERVIDFLTHIGEAFEGVLPVEIALSGGYCLQRLDLSAADEYLVAFVRNWAALVALSDKQVNPFQSRLRDLLSTRNTQKRFRLYFRAVVLLQIECAAQSGHNQHVSAVYNIQALDAILNPVAREELQKYQVTCLQEAARHREVLSTVAAPLASTVPPSTTPTALAPCKQQEMPRDTLTEAARESAAIPSPSRRTNWRWNAIRIGVILLLAVLLRFTSGRFVRALKSALQITRAAPARRRTLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HLY1</accession>
    <name>A0A836HLY1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SUI1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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</entry>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1105"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1138"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1622"/>
            <end position="1632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1738"/>
            <end position="1749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5481330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1749" mass="184404" checksum="2579650541942614" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HR56</accession>
    <name>A0A836HR56_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cilia- and flagella-associated protein 299</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_06770</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in spermatogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000009">
        <property type="protein sequence ID" value="KAG5486063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065394.1">
        <property type="nucleotide sequence ID" value="XM_067208683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HR56"/>
    <dbReference type="SMR" id="A0A836HR56"/>
    <dbReference type="GeneID" id="92362617"/>
    <dbReference type="KEGG" id="loi:92362617"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027887">
        <property type="entry name" value="DUF4464"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33588">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33588:SF1">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14713">
        <property type="entry name" value="DUF4464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5486063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="232" mass="26655" checksum="FA4C54462C4817E4" modified="2021-09-29" version="1">MAATERDGSDRNVLDFNAYEDYLDQQVTGEDLFYLEDEDAARKAVELGYKRKDVLSREEFEAAQQLARTGPLKRRESTEVITSAGKDVSDSPLLTALAKREELVRTGKLATVLFLRDYVNGQEVSAYIDYGHRLRSENFEAYFKKEKKLLPKRSDLSYYNWKTHTLFYNNSPTFQVLADSSLGLVMKHKRDRKAIHVDPNAASPGENCSRTVVPCKDYLQVVIYDHVTRRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HR76</accession>
    <name>A0A836HR76_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-synthesizing GTPase</fullName>
            <ecNumber evidence="2">3.6.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_06801</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="2"/>
    <dbReference type="EMBL" id="JAFHLR010000009">
        <property type="protein sequence ID" value="KAG5486093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065424.1">
        <property type="nucleotide sequence ID" value="XM_067208713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HR76"/>
    <dbReference type="SMR" id="A0A836HR76"/>
    <dbReference type="GeneID" id="92362647"/>
    <dbReference type="KEGG" id="loi:92362647"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01888">
        <property type="entry name" value="eIF2_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03688">
        <property type="entry name" value="eIF2_gamma_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15490">
        <property type="entry name" value="eIF2_gamma_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000009">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000065">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000075">
        <property type="entry name" value="Translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050543">
        <property type="entry name" value="eIF2G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015256">
        <property type="entry name" value="eIF2g_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044127">
        <property type="entry name" value="eIF2g_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044128">
        <property type="entry name" value="eIF2g_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003077">
        <property type="entry name" value="PRK04000.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09173">
        <property type="entry name" value="eIF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="47"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5486093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="479" mass="52542" checksum="38E7CD32AE12EB87" modified="2021-09-29" version="1">MAEEDIADFTLDDENVIDTDHGLAKQDFSKINLDELNVDTFEVMSRQATINVGTIGHVAHGKSTVVKALSGVKTQKFHREAVMNITIHLGYANAKVYQCGTCPRPICYQTYPSSQPDSTPCPNCGETMTLKRHFSFVDCPGHDVLMATMLNGAAIMDAALLLIAANEPFPQPQTLEHLKAVEIMKLRHLVVLQNKIDLVGEVKAHDQYRQVRAYLDNIALNVPIVPISAQLKRNVDYLLEYLLHIPMPVRQLKAPVRMTVVRSFDINKPGEGDIESLKGGVAGGTVTQGVIKVGQVVEIRPGLVRSRSSNEQGGRFTYSPLKTRTVTLKAENNVLQYAIPGGLIAIGTTLDPTLTRQDKMVGNMLGEEGTLPEVYCEIEVQYYLFSEMVGAKSKDGKSTAKRVQKLNVLESLQINVGTLTAGATVLNITQDPEIAKLELVTPVCCSTGEQVAISRMVDKTFRLIGWGTIRRGVPMKQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HRW0</accession>
    <name>A0A836HRW0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription factor IIB C-terminal module 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_07286</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000015">
        <property type="protein sequence ID" value="KAG5483071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064567.1">
        <property type="nucleotide sequence ID" value="XM_067209184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HRW0"/>
    <dbReference type="SMR" id="A0A836HRW0"/>
    <dbReference type="GeneID" id="92363118"/>
    <dbReference type="KEGG" id="loi:92363118"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00043">
        <property type="entry name" value="CYCLIN_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041189">
        <property type="entry name" value="TFIIB_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054332">
        <property type="entry name" value="TFIIB_C_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18542">
        <property type="entry name" value="TFIIB_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22108">
        <property type="entry name" value="TFIIB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22109">
        <property type="entry name" value="Zn_ribbon_tTFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor IIB C-terminal module 1" evidence="2">
        <location>
            <begin position="125"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor IIB C-terminal module 2" evidence="3">
        <location>
            <begin position="233"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="387"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5483071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="419" mass="45200" checksum="8045A9CAC0318CBD" modified="2021-09-29" version="1">MATAADYVGKNCPYCGAIDSIETDEARGEAACVNCATVVAMGLEENVATRFEKDATYADVDRGGDVGWDLENGGAIGRATSKTTGLTREEAAAAAAGLLRRPNAAALGSNAGPFGDTAKYAKTKLHPRMSGQLEAFFRLSRRCDESILRDAIALAKHFVGFRRERGVRVEHQTEVAAASVMLAAELLGQPIPLSEMRVLDGTLKDVESRRQEVLEAANLGQEMAQVAKKYVPNLIHYYVQLLQLPLISYEMPCIALFHAIRQCESKPDPGASELAMFVEAEKVVMAVLLARTEPRLVWPNKPPPPAEPSRTTLYSSFASSAHLQPGRVEKLMRVAEKAVPLIQPEFDRLMQTPEFATTAMRTMGEAVVRMSVKTKDSKLDAPLKLEPGPTSAPSAPSTAGAGQKRSRSATPPPLPSSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HUB6</accession>
    <name>A0A836HUB6_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_07451</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Folate-biopterin transporter (TC 2.A.71) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000004">
        <property type="protein sequence ID" value="KAG5487773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065970.1">
        <property type="nucleotide sequence ID" value="XM_067209338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HUB6"/>
    <dbReference type="GeneID" id="92363272"/>
    <dbReference type="KEGG" id="loi:92363272"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039309">
        <property type="entry name" value="BT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31585">
        <property type="entry name" value="FOLATE-BIOPTERIN TRANSPORTER 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31585:SF51">
        <property type="entry name" value="TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03092">
        <property type="entry name" value="BT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5487773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="141" mass="15435" checksum="28D55C260FE78271" modified="2021-09-29" version="1">MLNYMPLNMLILRLCPKGCKSAMFAILASFSNMGASTSSTIGAILMETVWPLSSSPPCDFSNLRWLLIVGHLITPLIAIPLVFLLIPGTRICDPIDPKDVEALSFFPKVTNFDREGSASSGLRFCRHARPDTCTRSVGACW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HX07</accession>
    <name>A0A836HX07_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="16">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">LSCM4_07987</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">LSCM4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 16">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 16">Membrane</location>
            <topology evidence="1 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="16"/>
    <dbReference type="EMBL" id="JAFHLR010000013">
        <property type="protein sequence ID" value="KAG5484420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064913.1">
        <property type="nucleotide sequence ID" value="XM_067209863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HX07"/>
    <dbReference type="SMR" id="A0A836HX07"/>
    <dbReference type="GeneID" id="92363797"/>
    <dbReference type="KEGG" id="loi:92363797"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000203">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF150">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 15 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14 16" id="KW-0547">Nucleotide-binding</keyword>
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    <keyword evidence="9 16" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="108"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="301"/>
            <end position="324"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
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            <begin position="351"/>
            <end position="373"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="867"/>
            <end position="886"/>
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    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="892"/>
            <end position="915"/>
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    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="945"/>
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    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="984"/>
            <end position="1000"/>
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    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1007"/>
            <end position="1030"/>
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    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1052"/>
            <end position="1073"/>
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        <location>
            <begin position="42"/>
            <end position="108"/>
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            <begin position="140"/>
            <end position="200"/>
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    </feature>
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        <location>
            <begin position="831"/>
            <end position="1080"/>
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    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="13">
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            <position position="418"/>
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        <ligand>
            <name>ATP</name>
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        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
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            <dbReference type="ARBA" id="ARBA00034036"/>
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            <dbReference type="RuleBase" id="RU362033"/>
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    <evidence type="ECO:0000259" key="17">
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        <source>
            <dbReference type="Pfam" id="PF16212"/>
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        <source>
            <dbReference type="EMBL" id="KAG5484420.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="21">
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            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1097" mass="124208" checksum="B5E99847CFA59620" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HXF3</accession>
    <name>A0A836HXF3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LSCM4_07869</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">LSCM4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000013">
        <property type="protein sequence ID" value="KAG5484303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064796.1">
        <property type="nucleotide sequence ID" value="XM_067209746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HXF3"/>
    <dbReference type="SMR" id="A0A836HXF3"/>
    <dbReference type="GeneID" id="92363680"/>
    <dbReference type="KEGG" id="loi:92363680"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000005">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000004">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032740725" description="Tubulin alpha chain" evidence="10">
        <location>
            <begin position="29"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="11">
        <location>
            <begin position="167"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="12">
        <location>
            <begin position="366"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG5484303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="569" mass="62358" checksum="3E6579EDB605F5D4" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836K9B1</accession>
    <name>A0A836K9B1_9TRYP</name>
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        <recommendedName>
            <fullName evidence="4">NADH-ubiquinone oxidoreductase complex I subunit</fullName>
        </recommendedName>
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    <gene>
        <name evidence="2" type="ORF">LSCM4_00379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058562.1">
        <property type="nucleotide sequence ID" value="XM_067202461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836K9B1"/>
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    <dbReference type="GeneID" id="92356395"/>
    <dbReference type="KEGG" id="loi:92356395"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5464931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="259" mass="30253" checksum="C86547A1F5E3B5BD" modified="2021-09-29" version="1">MTVADGERSDGSHAHDGARGGHDAVTAPHEKIKVPSMASQDYLDNLPAFDTTKPMPKPRSAVERFTRLLQLQFGQDPDMPTLGHNTERKYRSLFDYLASPITPLRPRTYIDSHTRPNPCPEEYWWASWRWPRTKYVNAKVPPPVDGKYTDYYHYLAFKNWLERERDVYVAHANLVHEMTSRCLVKEGQYNAAKNCRHLYHKGFAMSRMEEFNQAMLYMAMTGNAAIRETPYPENFVEEKRKIYDDWLYRTRMRKPGDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KA46</accession>
    <name>A0A836KA46_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_00010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058203.1">
        <property type="nucleotide sequence ID" value="XM_067202102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KA46"/>
    <dbReference type="GeneID" id="92356036"/>
    <dbReference type="KEGG" id="loi:92356036"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5464572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="897" mass="103057" checksum="D9C517F7369FC1CE" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KA90</accession>
    <name>A0A836KA90_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_00178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058368.1">
        <property type="nucleotide sequence ID" value="XM_067202267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KA90"/>
    <dbReference type="SMR" id="A0A836KA90"/>
    <dbReference type="GeneID" id="92356201"/>
    <dbReference type="KEGG" id="loi:92356201"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5464737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="106" mass="12125" checksum="1833995C28C97379" modified="2021-09-29" version="1">MFRRALGASSGRSLSSASAAVSHRRYTELSHMKFPVYYSAVGAVAGYFVVMWIVFLRMGSKSTARSEFKDDYLRVWRRKLGTGYQWADAWGPQMDTIFKDLPEEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KAI0</accession>
    <name>A0A836KAI0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA repair protein RAD2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_01552</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059291.1">
        <property type="nucleotide sequence ID" value="XM_067203600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KAI0"/>
    <dbReference type="SMR" id="A0A836KAI0"/>
    <dbReference type="GeneID" id="92357534"/>
    <dbReference type="KEGG" id="loi:92357534"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000113">
        <property type="entry name" value="DNA repair protein RAD2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039436">
        <property type="entry name" value="Asteroid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001044">
        <property type="entry name" value="XPG/Rad2_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF59">
        <property type="entry name" value="FI23547P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12813">
        <property type="entry name" value="XPG_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00066">
        <property type="entry name" value="XRODRMPGMNTG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="7">
        <location>
            <begin position="640"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="172"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="390"/>
            <end position="458"/>
        </location>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="467"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5466087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="491" mass="53713" checksum="BC9013E4AC25375D" modified="2021-09-29" version="1">MHISEVLLLGFTLASLGFSAWRQTSGQRGDPDDETEDRDEHMARAAPLPIPVTHVAFSGERGFRKPPRNSHASDQRQRTPAAQVLSDDADVDNVALSPGSTDSGSAAAVDVSVDAGASLSLSATADPLLTVLSRLPLEEKLSITVNWLSSVSNCLTYFLRPSQVLYTFLFTNGHLVLFATSYSRRYLHLHPDQLPARRQPALYASFPSDSRREACVNHWLAASRAKGATAELQISDTVVYVGSSGSEPASVIVPPPSMRSLFKSVSTAVPERRQHHGNDYHSRGSCVAECEVEDPPFAGEVAMASPPHPSPPTVTLRRPRRWLWWYLRRGVAPAQAQLSGLLIFNALFTATLFIFHQYYLFFELGTLSGYMAAVASVFLCGMETGCIVVRLRRRWQRGRTAQTPSEGAAVDGMPSTDDLLLGADPYGGVQGPAIAYLGEHLSTGACAALYVWMLLDEGDALWVSHTALVRWYVCPLFTVIFSVLKCLRVFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KBU5</accession>
    <name>A0A836KBU5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CCDC81 HU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_00547</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058726.1">
        <property type="nucleotide sequence ID" value="XM_067202625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KBU5"/>
    <dbReference type="GeneID" id="92356559"/>
    <dbReference type="KEGG" id="loi:92356559"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040673">
        <property type="entry name" value="CCDC81_HU_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028034">
        <property type="entry name" value="HU-CCDC81"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14908">
        <property type="entry name" value="HU-CCDC81_euk_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18289">
        <property type="entry name" value="HU-CCDC81_euk_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCDC81 HU" evidence="1">
        <location>
            <begin position="21"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="CCDC81 HU" evidence="2">
        <location>
            <begin position="125"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5465095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="264" mass="29630" checksum="5AFA20CA075179ED" modified="2021-09-29" version="1">MTEPFSCSGRVCRGCYGEIAEIVTHVNGLYMLQTRRRGTAHELNVIWRALGEQLEELLIKKRSGIVLDFLHASIKVQRVMLFDKSIAVELKPQLVLLPDFTSKFHLKNVLEMRDAHYHATVPDAVSYIAIAHITGTDHFVVEAAVKDSVREIGKYLQRNAASTLTIDIGVGFLEFQNRSYRMKWNPEFLARLDASVGVAEVVRPYDPPSMTVGGPTAPCRFQKGCTSEGLLQTQVRDTVLAESRFTAAELNDGMSSSSYRRTHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KBX8</accession>
    <name>A0A836KBX8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LSCM4_01123</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5468036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059838.1">
        <property type="nucleotide sequence ID" value="XM_067203188.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836KBX8"/>
    <dbReference type="GeneID" id="92357122"/>
    <dbReference type="KEGG" id="loi:92357122"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016242">
        <property type="term" value="P:negative regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05169">
        <property type="entry name" value="PIKKc_TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000441">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000039">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000034">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.150">
        <property type="entry name" value="FKBP12-rapamycin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009076">
        <property type="entry name" value="FRB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036738">
        <property type="entry name" value="FRB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057564">
        <property type="entry name" value="HEAT_ATR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024585">
        <property type="entry name" value="mTOR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026683">
        <property type="entry name" value="TOR_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF121">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08771">
        <property type="entry name" value="FRB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23593">
        <property type="entry name" value="HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11865">
        <property type="entry name" value="mTOR_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01345">
        <property type="entry name" value="Rapamycin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47212">
        <property type="entry name" value="FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PDZ" evidence="10">
        <location>
            <begin position="1343"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="domain" description="FAT" evidence="12">
        <location>
            <begin position="1437"/>
            <end position="1986"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="11">
        <location>
            <begin position="2150"/>
            <end position="2476"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="13">
        <location>
            <begin position="2593"/>
            <end position="2626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2435"/>
            <end position="2501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2544"/>
            <end position="2566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="2447"/>
            <end position="2464"/>
        </location>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KCX6</accession>
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            <taxon>Metakinetoplastina</taxon>
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            <taxon>Trypanosomatidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Jariyapan N."/>
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            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
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            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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            <dbReference type="Pfam" id="PF15016"/>
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            <dbReference type="EMBL" id="KAG5469206.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
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</entry>
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    <accession>A0A836KCZ4</accession>
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        <name evidence="12" type="ORF">LSCM4_00943</name>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
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            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
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    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-1 OGG1 family.</text>
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    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="OGG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052054">
        <property type="entry name" value="Oxidative_DNA_repair_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242">
        <property type="entry name" value="8-OXOGUANINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242:SF2">
        <property type="entry name" value="N-GLYCOSYLASE_DNA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07934">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
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</entry>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="854" mass="91348" checksum="C6BB2C77792023A3" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <end position="55"/>
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        <source>
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            <dbReference type="EMBL" id="KAG5470377.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
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    </evidence>
    <sequence length="188" mass="21213" checksum="41F39D0F79288278" modified="2021-09-29" version="1">MSSTERLTDAFRLQFQWIPVLITDRSHHTSGERKRCTLFAVLHVAFVLVIFGHFMSIIVSWALAFILQAGAMGLCLIHLAMLEEYADRMNNALELEHTVNPLIVAGVAVRCFACLQCVLTRSWPILLAGSVEIMYDLYVAQQRSLLIDGTTIWKEIGTFRTDGRIRVAYQVTMVVGAVVYLIYSIMTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="95"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5473571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="197" mass="22180" checksum="C510BB781A743B37" modified="2021-09-29" version="1">MQCNTIPYVRRAIAVSAVFLPLVSLRAHQGRSHSSSGYTLHTTGAPDLQSSGSLLASAAGFRRFASRDRLCAGGSSTPRGREGLTEADLDPPQMPSPQQYASYDEYLNAYDQYLQETTQFLSSARAFLQNRLRHLRRAHAGISEAVRREYFWTFVPFICALCVHMVDSQHHVNAQITRERLKERAKEHVKSVKWVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836KGZ2_9TRYP</name>
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        <recommendedName>
            <fullName evidence="7">Hcy-binding domain-containing protein</fullName>
        </recommendedName>
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    <gene>
        <name evidence="8" type="ORF">LSCM4_00672</name>
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    <organism evidence="8 9">
        <name type="scientific">Leishmania orientalis</name>
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    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058849.1">
        <property type="nucleotide sequence ID" value="XM_067202748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KGZ2"/>
    <dbReference type="SMR" id="A0A836KGZ2"/>
    <dbReference type="GeneID" id="92356682"/>
    <dbReference type="KEGG" id="loi:92356682"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008898">
        <property type="term" value="F:S-adenosylmethionine-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033528">
        <property type="term" value="P:S-methylmethionine cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.330:FF:000002">
        <property type="entry name" value="Homocysteine S-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="entry name" value="Homocysteine-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017226">
        <property type="entry name" value="BHMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051486">
        <property type="entry name" value="Hcy_S-methyltransferase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007020">
        <property type="entry name" value="PRK09485.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46015:SF1">
        <property type="entry name" value="HOMOCYSTEINE S-METHYLTRANSFERASE-LIKE ISOFORM 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46015">
        <property type="entry name" value="ZGC:172121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037505">
        <property type="entry name" value="Betaine_HMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="Homocysteine S-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="7">
        <location>
            <begin position="1"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR037505-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5465218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="320" mass="34238" checksum="934ED76F1216473D" modified="2021-09-29" version="1">MEAFLADPRHIVMLDGGLATELERRGCNLLDPLWSGKALLESPQQIQDVGLSYLQAGARCIITASYQITPESLMEHRHLTEDAAVAVIEESVRIAQVAREQHVKENPQTAPVFVAGSVGPYGAYLADGSEYRGDYARSAEEFKEFHRSRIAALLRAGVDVLAIETQPSAPEVRAIVALLQENHPSCRAWVSFTTSRTSPVDAIGDGTKWADIIPFLEKAPQVVAVGVNCIPMAEASAVLAHLHTLTTMPLVVYTNSGESYDPVTMTWHPISVSDGATLSLPALAQEWASHGARLIGGCCRTGPSDVAGAVAALSNTGFIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KJD1</accession>
    <name>A0A836KJD1_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_00897</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059615.1">
        <property type="nucleotide sequence ID" value="XM_067202965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KJD1"/>
    <dbReference type="GeneID" id="92356899"/>
    <dbReference type="KEGG" id="loi:92356899"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052201">
        <property type="entry name" value="LRR-containing_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111:SF0">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="633"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="747"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="642"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5467813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="770" mass="80245" checksum="ECD3B27E801377F8" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KJI6</accession>
    <name>A0A836KJI6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA/rRNA methyltransferase SpoU type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_05529</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5478129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063036.1">
        <property type="nucleotide sequence ID" value="XM_067207468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KJI6"/>
    <dbReference type="SMR" id="A0A836KJI6"/>
    <dbReference type="GeneID" id="92361402"/>
    <dbReference type="KEGG" id="loi:92361402"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002128">
        <property type="term" value="P:tRNA nucleoside ribose methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004384">
        <property type="entry name" value="RNA_MeTrfase_TrmJ/LasT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42786:SF2">
        <property type="entry name" value="TRNA (CYTIDINE_URIDINE-2'-O-)-METHYLTRANSFERASE TRMJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42786">
        <property type="entry name" value="TRNA/RRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="197"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5478129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="465" mass="51989" checksum="CB70034AD658601E" modified="2021-09-29" version="1">MLSFSVKRLVQKDFDAWGYHIQWPQNEVLTPLTGKVGFAVEDIKFAYNAWSLLRLAMFFGVHHPKVLSNMSKTTPSMDIMESGNRLFFMHSRVNAKLSQSKVRVALTPNHPHAFPVQQLVSDGHCRLSQLQPAGIELVLGMENGLSQEVVDGCDLCAYIPQYGSIGSLSMLSALAIAAHSMWRRAVKEAGNTSHLISALQRASQGHMPQANSPRREKGSLPHEKDLLGCSNTTIKALLKERRRAFDLQVSVLIYNHLGDRNIGAVIRNANAFNCEYVAILNRRRFNRRGALGTEKVQDVFFFETIDQDAARHLFEGYEIWLLYPYYPNLLVHDAGQEGGTSCPSSTFLRHEDPVLAAWGATQHQLTSEHPLVIRHPHLCRQEVFLDDDSSLASCVQDVKRRNLRGILLAVPEEGCSPHSCLCELSRRVVYVTSPSFLPQKTQRGLNPALSTAIALERLRCAADSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KJS9</accession>
    <name>A0A836KJS9_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_04089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="248" mass="26948" checksum="BD80D1B17E66CD37" modified="2021-09-29" version="1">MSGTVMCTSTSECVYVAGERARSPAASPSADMLSELASHVARSAITPYGARVPKESAESVLLKQRMELIKTVAAIRASEDTFGSSQVSMHGRTPPQVKAVQRDKTRKPLYPTTATGRYKAIKDLKAEIGAQPDAAQLHGSSRGNTAPGSLVSAESPQVIDNAGLDPRQSVAEKHRAALITTRPRVPTRIEQSIVSFNRSLGAVKPYAMSRSAKLETRCCFADLPHDTNDRYVERMQSCRPFKGLYSYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">WWE domain-containing protein</fullName>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="Pfam" id="PF02825"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5474695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="protein sequence ID" value="KAG5479734.1"/>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="235" mass="25663" checksum="DE0B789EA51E3ADA" modified="2021-09-29" version="1">MWRPTATCWGSSMELSTSSRAYWAANMQRRCKTSLSSANGLRSHGNFRAGTVKSTPFQVKPGTTAPMWQPSAKYMKYKPVRWLSDNLLVIATYQLTLEVGFTITFGGLLYADKITAKGVCEGLAAYHYPFVDWIDVESGVYTDPVRVGPFTLNARKMTALHTGHNIANGLLPLQVLLLATTFVPAQYAYRLVRHTTPSTPAAAATVPPTFTSTGGQRASYARATGAKKSSPVSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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    <organism evidence="2 3">
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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            <begin position="405"/>
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    <evidence type="ECO:0000256" key="1">
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836KMW6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RRM domain-containing protein</fullName>
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    <organism evidence="3 4">
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000018">
        <property type="protein sequence ID" value="KAG5481309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067208925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KMW6"/>
    <dbReference type="SMR" id="A0A836KMW6"/>
    <dbReference type="GeneID" id="92362859"/>
    <dbReference type="KEGG" id="loi:92362859"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000707">
        <property type="entry name" value="RNA binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15241:SF386">
        <property type="entry name" value="RNA-BINDING REGION RNP-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15241">
        <property type="entry name" value="TRANSFORMER-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="26"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="119"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5481309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="346" mass="37726" checksum="06EBC4D2F5163218" modified="2021-09-29" version="1">MQYVPVAAAGSARCPSQMQFYTPSSTNLFVRYLPREVDDNLLREIFSVFGNITSSMVMRDIHSGQSLGTAFVRYEEHEEALRALRDAQGMPLFGKTVSVQWAKQQHDGTPAGSDRLKMNKLFLRNVPLEVTEKDLVDLVGSHGSVVKVTMHNDTAPLVDSMERRRIAFITFEHFGAAEAALRAVHSTCAFPQCRGIPLMGKLINDAVKSKRHRVESTVSEGAGFEFGTVHAVPAVARSTPVTVAPLSSLEVNGPSRSCVESLTLSHAPQFISSSEDSVANTPSRSCCGSQFDMVAVMPTRAVPAMVPRPIVCDSSESSLQRSASDGSYSARFCHNPYSLSYGRTYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KN14</accession>
    <name>A0A836KN14_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_07156</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000018">
        <property type="protein sequence ID" value="KAG5481444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064123.1">
        <property type="nucleotide sequence ID" value="XM_067209060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KN14"/>
    <dbReference type="SMR" id="A0A836KN14"/>
    <dbReference type="GeneID" id="92362994"/>
    <dbReference type="KEGG" id="loi:92362994"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045194">
        <property type="entry name" value="MGRN1/RNF157-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22996">
        <property type="entry name" value="MAHOGUNIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22996:SF0">
        <property type="entry name" value="RE60872P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="2">
        <location>
            <begin position="106"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5481444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="155" mass="17105" checksum="BE9A01B2B3E6634F" modified="2021-09-29" version="1">MSGLELIALVPIGIAGWKLFQKLGDQQSLIIQHELTINNQKELLESIVRADRGSPLRSPFSLAVVAGTLVLAGTVTYKSWTLSKACTVRPPPNYEPTQATFDAEQCVICLENCKDTVFLPCRHLCTCWSCASRIGNSACPTCRARIEAMQFVYQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KNG4</accession>
    <name>A0A836KNG4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_06956</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="JAFHLR010000017">
        <property type="protein sequence ID" value="KAG5481879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064239.1">
        <property type="nucleotide sequence ID" value="XM_067208865.1"/>
    </dbReference>
    <dbReference type="GeneID" id="92362799"/>
    <dbReference type="KEGG" id="loi:92362799"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF758">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="679"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="156"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="301"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="446"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="601"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="799"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1135"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1295"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="302"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="806"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="817"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1140"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1155"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1299"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1310"/>
            <end position="1321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5481879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1321" mass="140683" checksum="83D411D171C2D11C" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KNM1</accession>
    <name>A0A836KNM1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NTF2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_05759</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000021">
        <property type="protein sequence ID" value="KAG5479752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063463.1">
        <property type="nucleotide sequence ID" value="XM_067207690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KNM1"/>
    <dbReference type="SMR" id="A0A836KNM1"/>
    <dbReference type="GeneID" id="92361624"/>
    <dbReference type="KEGG" id="loi:92361624"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00780">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000035">
        <property type="entry name" value="Hypothetical_protein_-_conserved"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039539">
        <property type="entry name" value="Ras_GTPase_bind_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10693:SF20">
        <property type="entry name" value="AT27578P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10693">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="NTF2" evidence="3">
        <location>
            <begin position="15"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="205"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="239"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="313"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="325"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5479752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="428" mass="48401" checksum="FD8E3FC1BEF3EE6A" modified="2021-09-29" version="1">MSEQQSLAPETAFTVASTFLAYYYSEFVKLNELARMSDLYDERSYMTLVDFRDEVPVVAHGRNAVANLLAKLDSTLGQRKVEIITVDTVALPHNCVQVICQGVMYLREYRRVFLHVFMLEPTAYRTKTYHIASDYLRFVDSEKEVIPEGSVVIAADQVAAYLEESRRRVEEEQRRQLLEFQQRIRLQQQQLQRQQLQMQQQQQRKVAAESATESAAAISTPASAPRQTRPAASSSHDQTQPREQRPTRPPRDGVRLARGADPREQRGEHKPRDGPRGQCESLGERKPREPRGEWKSREGEEKAVAASQSRPGGEGKKGGERPNRKPAAAAKGAAAAGPNPAAERKPRRESAPTAAIIILRVPKKIKLSDIKAELISQGFSEPEDLFWCGRGSAHAVLKFSVVEKATQMFEKRPFKMQNETLNMDYYHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KTQ2</accession>
    <name>A0A836KTQ2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EMG1/NEP1 methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_05679</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000016">
        <property type="protein sequence ID" value="KAG5482420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064426.1">
        <property type="nucleotide sequence ID" value="XM_067207612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KTQ2"/>
    <dbReference type="SMR" id="A0A836KTQ2"/>
    <dbReference type="GeneID" id="92361546"/>
    <dbReference type="KEGG" id="loi:92361546"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070037">
        <property type="term" value="F:rRNA (pseudouridine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18088">
        <property type="entry name" value="Nep1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005304">
        <property type="entry name" value="Rbsml_bgen_MeTrfase_EMG1/NEP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636:SF11">
        <property type="entry name" value="EMG1_NEP1 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636">
        <property type="entry name" value="NEP1/MRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03587">
        <property type="entry name" value="EMG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5482420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="32594" checksum="1381317A8A79B80B" modified="2021-09-29" version="1">MEYAQKSARLPRSAEEKERWKRVIVILEHCPLQTIQTDRGFELLSDRHRAYHARHNQDPADWRPDVVHQCLLHLQDSALNRAGMLEVFLRTKKQVCIAVDPRLRVPRNVRLFEKMMVSLLFKLKVRACTGYLSLLRVVGNPITDHIPAGTRLYRVEKDGDLIDPFAFCASCGYAADVLDELRADRKISLARRRLTSSTSGTLEETVAEAGTDEFAKVQRKAAERRRFQPFAFIIGGMSRGDVSVDYARPGEVSSIRLGDRGMSAAAVISTLLHGFEEEWLREDNEAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KU07</accession>
    <name>A0A836KU07_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">COPI associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_06573</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000010">
        <property type="protein sequence ID" value="KAG5485617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065201.1">
        <property type="nucleotide sequence ID" value="XM_067208490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KU07"/>
    <dbReference type="GeneID" id="92362424"/>
    <dbReference type="KEGG" id="loi:92362424"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013714">
        <property type="entry name" value="Golgi_TVP15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28128">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28128:SF1">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08507">
        <property type="entry name" value="COPI_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
            <dbReference type="EMBL" id="KAG5482990.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="187" mass="21275" checksum="C5E6533FFF2BDFA8" modified="2021-09-29" version="1">MRRLSSQLTCTAAAVRFASAGGAKKYDLFGYEVDTNTAPWIEKVKQCRYYDEAGEVLVSMNVKNCPPDLETYNATLQKIFEAPSKQCNPVENESKFCAMMDLMEEMQHRNKVKPNEESWTWVMKECVQSGQFRLGYCVAKLMEAEFKRVPADLVKKNEENAAKAKADGKEHPSTLAQQQSLFEIKIQ</sequence>
</entry>
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                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
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                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAG5488180.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
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                <person name="Gatherer D."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
            <dbReference type="EMBL" id="KAG5486488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
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    </evidence>
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<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067202767.1"/>
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    <dbReference type="KEGG" id="loi:92356701"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF110">
        <property type="entry name" value="2-PHOSPHOXYLOSE PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032503301" description="Histidine secretory acid phosphatase" evidence="4">
        <location>
            <begin position="24"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="898"/>
            <end position="917"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5465237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="988" mass="107266" checksum="03F92EB1F4F233A4" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FTX0</accession>
    <name>A0A836FTX0_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060204.1">
        <property type="nucleotide sequence ID" value="XM_067204652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836FTX0"/>
    <dbReference type="GeneID" id="92358586"/>
    <dbReference type="KEGG" id="loi:92358586"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35615:SF7">
        <property type="entry name" value="PRESENT IN THE OUTER MITOCHONDRIAL MEMBRANE PROTEOME 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35615">
        <property type="entry name" value="PRESENT IN THE OUTER MITOCHONDRIAL MEMBRANE PROTEOME 22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5469227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="558" mass="59026" checksum="A7E664CD8D96493E" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FYP4</accession>
    <name>A0A836FYP4_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="1" type="ORF">LSCM4_03315</name>
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    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
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            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060879.1">
        <property type="nucleotide sequence ID" value="XM_067205327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836FYP4"/>
    <dbReference type="GeneID" id="92359261"/>
    <dbReference type="KEGG" id="loi:92359261"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5471762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="120" mass="12829" checksum="7502C3ADF482B14B" modified="2021-09-29" version="1">MHGAVRRLVPKEAFYPLEKLARNRDTKIVACAHYFAIDPAAARDGSTPAGEDSSSSQSFAAHCVGCTKILSAANDLVQQLKASAHDIPTIGTRTLKKHFGHLSAYVLQDARGGYFVTGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G3X8</accession>
    <name>A0A836G3X8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_00335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058520.1">
        <property type="nucleotide sequence ID" value="XM_067202419.1"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A836G3X8"/>
    <dbReference type="GeneID" id="92356353"/>
    <dbReference type="KEGG" id="loi:92356353"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055325">
        <property type="entry name" value="CF161"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24274">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24274:SF1">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5464889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="560" mass="61538" checksum="4770C39E14135143" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G3Z2</accession>
    <name>A0A836G3Z2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-type proton ATPase proteolipid subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_03862</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Vacuole membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061793.1">
        <property type="nucleotide sequence ID" value="XM_067205856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G3Z2"/>
    <dbReference type="SMR" id="A0A836G3Z2"/>
    <dbReference type="GeneID" id="92359790"/>
    <dbReference type="KEGG" id="loi:92359790"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18175">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18176">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000001">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011555">
        <property type="entry name" value="ATPase_proteolipid_su_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01100">
        <property type="entry name" value="V_ATP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="10">
        <location>
            <begin position="49"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="10">
        <location>
            <begin position="128"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5474687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="201" mass="20300" checksum="82183001F1E8DDA5" modified="2021-09-29" version="1">MPASVTKICGAGCMLAVAGATVSYCIDPANVDACMAIMYPQSAGFFGAMGAAVALVFANLGSAYGAAKSGVGVAYLGLTAPEKIMRGIVPVVMAGILGIYGLIIAVIINNNIHTEDASYSSYAGYLHLGAGLAAGLAALGAGLSIGVVGDTAARAYGKQDQIFVAMVLMLIFSEALGLYGLIIALLMNNQANRYTDLCSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G4V1</accession>
    <name>A0A836G4V1_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5468031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059833.1">
        <property type="nucleotide sequence ID" value="XM_067203183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G4V1"/>
    <dbReference type="GeneID" id="92357117"/>
    <dbReference type="KEGG" id="loi:92357117"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5468031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="304" mass="34558" checksum="41253F6C6906A014" modified="2021-09-29" version="1">MGHRADTNKYAAYRGARLLQRRIGSFVLAFAVFLIALSMIFSALQDREARCQERAHEIEFEFIVNPGYAREDVVTALQAILEERSCFLDFPPQNDDVPNVVQLDVLDTTTNFIAKRGFRLVRRSDGSSYFFQLTAIFDRLCGTYPPFTMEVLPNVDYEKVTYHIKAVSLTNNTVMYLQQSSLFTQDSNRVTTVTQLQSLFPGFQQFGLSAARFSPVQSSSYTIEGVSQVYFSGSPLDIRFVIQRWHPDQDTPGFWRVVMSTQNIMAEQNLISLESSVRQGLGLRNLLCNSTSPNCADRVDIHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G6P2</accession>
    <name>A0A836G6P2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL15/eL18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_01570</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059309.1">
        <property type="nucleotide sequence ID" value="XM_067203618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G6P2"/>
    <dbReference type="GeneID" id="92357552"/>
    <dbReference type="KEGG" id="loi:92357552"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.100.10.10:FF:000015">
        <property type="entry name" value="60S ribosomal protein L27A/L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_uL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_uL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="4">
        <location>
            <begin position="72"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5466419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="145" mass="16040" checksum="7E7D69EEBA8A904A" modified="2021-09-29" version="1">MPTRFKKCRHQRGSTFCGYGRVGKHRKHESGRGNAGGMHHHRINFDKYHPGYFGKLGMDHYHRKKNPAWKPTINLNNLTRLIAADEAARATRGGSLPVVDLPSCGYAKLLGNGHIQAPCIVTARYVSKLADKKIRKAGGAVVLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G7I4</accession>
    <name>A0A836G7I4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Vps52 coiled-coil domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_00995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059711.1">
        <property type="nucleotide sequence ID" value="XM_067203061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G7I4"/>
    <dbReference type="GeneID" id="92356995"/>
    <dbReference type="KEGG" id="loi:92356995"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007258">
        <property type="entry name" value="Vps52"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048319">
        <property type="entry name" value="Vps52_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14190">
        <property type="entry name" value="SUPPRESSOR OF ACTIN MUTATIONS 2/VACUOLAR PROTEIN SORTING 52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14190:SF7">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04129">
        <property type="entry name" value="Vps52_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps52 coiled-coil" evidence="2">
        <location>
            <begin position="75"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="657"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="658"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5467909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="906" mass="99123" checksum="F658047B276DB007" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G9H7</accession>
    <name>A0A836G9H7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="7">5.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_02475</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="7"/>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060056.1">
        <property type="nucleotide sequence ID" value="XM_067204504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G9H7"/>
    <dbReference type="SMR" id="A0A836G9H7"/>
    <dbReference type="GeneID" id="92358438"/>
    <dbReference type="KEGG" id="loi:92358438"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004750">
        <property type="term" value="F:D-ribulose-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000171">
        <property type="entry name" value="Ribulose-phosphate 3-epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02227">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026019">
        <property type="entry name" value="Ribul_P_3_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004076">
        <property type="entry name" value="PRK05581.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="RIBULOSE-5-PHOSPHATE-3-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5469079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="256" mass="27602" checksum="7C2B2BC70B4445D4" modified="2021-09-29" version="1">MMTEFNRYNHEDKSTWLNAVERPKAPLEAIINPSILAADFCKLGDEVASVVSPAGGGVEWIHVDVMDGHMVPNISIGPCVISSLRARFPKLFLDVHCMVSDPKKWVPVVSKAGGSGYTFHIEATDDSKGLAEYIRAHGMQVGVAVKPATNLTQELRELLEGHYVDQVLVMTVEPGFGGQSFMSERLSFISELRRNYPDLNIGVDGGIGPGTAEMAADAGANILIAGTSVFRAGDRKAAIEELRASAKSGIFKNSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G9W6</accession>
    <name>A0A836G9W6_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_05430</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5478032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062939.1">
        <property type="nucleotide sequence ID" value="XM_067207371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836G9W6"/>
    <dbReference type="SMR" id="A0A836G9W6"/>
    <dbReference type="GeneID" id="92361305"/>
    <dbReference type="KEGG" id="loi:92361305"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16544">
        <property type="entry name" value="RING-HC_RNF138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000858">
        <property type="entry name" value="Zinc_finger_-_C3HC4_type_(RING_finger)/Ring_finger_domain/zinc-RING_finger_domain/EF-hand_domain_pair/EF-hand_domain/EF_hand/Secreted_protein_acidic_and_rich_in_cys teine_Ca_binding_region_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="16"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="245"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="281"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
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            <end position="361"/>
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    <feature type="domain" description="EF-hand" evidence="9">
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            <begin position="362"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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        </location>
    </feature>
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    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5478032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="395" mass="43819" checksum="EBA4D0B06B0E5545" modified="2021-09-29" version="1">MTNLCIGENFSEELTCAVCLDSWKDPIELAPCGHIFCKACAEGLKECPVCRGPISSTKAPNRTLVNIAKQIQVKCARCGWRGTREKGMSHACGNASGASPSQPSRPFSNTASSPQQHTSAANYSPPYAQNSSYAGYVLPPLQQQPQQLSYSDLWQSTAPAQAPQQSAEYSSNYGNTYPGPAFRPGGGNVGYQGGYPSTSNYPNQFGASCSGYKQQPQPSQSRQPSYQVIEPTGPRPWTLYGLGQSEYDQIVSLFVFFDDDDSGTLDRNEVARLARWLNFANTPQDVKRIFDDMDRDRSGRLSLGEFLTWLRCNKPNPQALYGLTQSQYNTIMMQFRMYDTNQDGCLEMNEFTRLVLNLGEVRDTATAQHLFRMIDQDRDGSISLHEFLTFRAGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GAU7</accession>
    <name>A0A836GAU7_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_04775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000023">
        <property type="protein sequence ID" value="KAG5478542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067206756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GAU7"/>
    <dbReference type="SMR" id="A0A836GAU7"/>
    <dbReference type="GeneID" id="92360690"/>
    <dbReference type="KEGG" id="loi:92360690"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
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            <begin position="11"/>
            <end position="26"/>
        </location>
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        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="209"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5478542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="269" mass="28364" checksum="7F12FF3A9E6A6B48" modified="2021-09-29" version="1">MPHAARQTKPSRSGSCRSSSSSAQSSPGGVDGRQATAKGALGASSSSARREATPLPESSETAKVSKGTAGGTDGAATAVAQRSGNGTFTESEKRRQATLFLGESEQFAFDFGGAVAEFADTIFEADAAQRAVQRAEELEETTARVLAASASHATASSRPLTLEEVNAYAADAMQHGPRRFLTLAKAGPRKRAATETSSVQAPQDGSGSVESALPASKQAEDENGATLEEAIPQFQAALRRYEADLWRAHKQRREEEARQRSKNKHSQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GEB0</accession>
    <name>A0A836GEB0_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000020">
        <property type="protein sequence ID" value="KAG5480417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067208108.1"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A836GEB0"/>
    <dbReference type="GeneID" id="92362042"/>
    <dbReference type="KEGG" id="loi:92362042"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="106"/>
        </location>
    </feature>
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        <location>
            <begin position="216"/>
            <end position="350"/>
        </location>
    </feature>
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        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
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        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
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        <location>
            <begin position="231"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="306"/>
        </location>
    </feature>
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        <location>
            <begin position="307"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5480417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="379" mass="41403" checksum="9BA1B0115616ED5C" modified="2021-09-29" version="1">MFALFATCLAPKRRLSGSPGINTAAAAASRRKVRVSSVGHKATPKARRGPSPGRAAGRPAKKRHERCPRTSRALALKPLSASSPSTSSALMPMANDAPGEAISAPQPRFSPSYVITDAMPVRSRFMNPVDFLSSSEPLMLTPEEKAAEKEEKARLLALQEDARGLAEMFARELAERKAKAIPAGVTKSGRPVAAAVVHTSSRAALNGAHQQRLPALFPPSSKLAPVAPKSPRSHHKFSFKAKRARGKADRQRRRLKASQRPRGLTPQCASRIRSRRSRQSKVTAAASVQMHKRHQALQRRPGRPRLRPTAAARIRAAASLPRFSAGGKKRPAAPPRRAAQAPRPVLKRTLPKSTVKVWRVAKPKKRIITKLRHRKRKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GEN7</accession>
    <name>A0A836GEN7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_03666</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061599.1">
        <property type="nucleotide sequence ID" value="XM_067205662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GEN7"/>
    <dbReference type="SMR" id="A0A836GEN7"/>
    <dbReference type="GeneID" id="92359596"/>
    <dbReference type="KEGG" id="loi:92359596"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001853">
        <property type="entry name" value="Dynamin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
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</entry>
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                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
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                <person name="Al-Salem W.S."/>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        </source>
    </evidence>
    <sequence length="159" mass="16569" checksum="1516C1D29CA2A7BC" modified="2021-09-29" version="1">MRGGGATAGTAVQITRSATEKLNAAIHGDEVGATNEYSLAGLVVVHRLGVVCQSRRASGWGLPRWSSGHPTSGTGSLSRPCSAVRSSHICNGTLRTVFGRARHCPSAKQPRGSLPLRCLAVGSDPERTRRTPRVGSPDCTEQAPPCRASSGVCRGVRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Bates M.D."/>
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                <person name="Al-Salem W.S."/>
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            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    <evidence type="ECO:0000256" key="1">
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
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            <taxon>Trypanosomatida</taxon>
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    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061690.1">
        <property type="nucleotide sequence ID" value="XM_067205753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GIY7"/>
    <dbReference type="GeneID" id="92359687"/>
    <dbReference type="KEGG" id="loi:92359687"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF301">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="276"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="11">
        <location>
            <begin position="162"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5474584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="357" mass="40488" checksum="58B2BC04ACDC06C6" modified="2021-09-29" version="1">MNTFVAEAPMWSTYYRRYDAPVAFDRPSSVSARGVATTIPPAVASKPKPKELPLPVVDPELYMRRRNSTREALGTFRRVHCFCFRFYFSADFLIGTIPTGITVVLIVANMALVWHQVGWCEYIVTFVVLATTFTAYFLTTSSDPGIYPRLRSGEQDPLEGNMQLIFCRECRLRRPPRCAHCYHCKVCVLEHDHHCSILGGCVGVRNLRWFALYLLSCSLSTMIGVVWLIRYLFYELFTSDDAEALDTGVKAVPTPFPTMQGGRRRFAPIDHTGSHLAAIFVLLLDGIVMLFVGGMLCMYMYLTLTSTTRRESMRKENSLKALLRPRVVWRNFKKLLSPPPSLLDSVVLGDEEAMNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GJA4</accession>
    <name>A0A836GJA4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LSCM4_02405</name>
        <name evidence="9" type="ORF">LSCM4_07271</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">LSCM4</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFHLR010000015">
        <property type="protein sequence ID" value="KAG5483057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059988.1">
        <property type="nucleotide sequence ID" value="XM_067204436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GJA4"/>
    <dbReference type="SMR" id="A0A836GJA4"/>
    <dbReference type="GeneID" id="92358370"/>
    <dbReference type="KEGG" id="loi:92358370"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02413">
        <property type="entry name" value="KH-II_40S_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1140.32:FF:000011">
        <property type="entry name" value="40S ribosomal protein S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.20:FF:000021">
        <property type="entry name" value="40S ribosomal protein S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="entry name" value="Ribosomal protein S3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057258">
        <property type="entry name" value="Ribosomal_uS3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_uS3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005703">
        <property type="entry name" value="Ribosomal_uS3_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01008">
        <property type="entry name" value="uS3_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760:SF32">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="Prokaryotic type KH domain (KH-domain type II)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="Ribosomal protein S3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="7">
        <location>
            <begin position="20"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAG5469011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5483057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="219" mass="24484" checksum="FCEBC901314BAE2E" modified="2021-09-29" version="1">MGPLSKKRMIIRDGVFYAELFEFLKRELAEEGFSGVSYHVTTLRTEIVIRATKTREVLGVNGRRIRELTACIQQRFNYKEGKLQLYVERVEVRGLSAMAQVESLRFKLLSNLQVRRAAMGIIRYVMESGAKGCEVTVGGKIKGQRAKSMTFRDGYMIKSGTAHKSFVDSACRHCYMRAGCIGVKVKIMLPGDSTGRNGPSEPLPDVITVIEPKQITAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GJY7</accession>
    <name>A0A836GJY7_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_00697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058874.1">
        <property type="nucleotide sequence ID" value="XM_067202773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GJY7"/>
    <dbReference type="SMR" id="A0A836GJY7"/>
    <dbReference type="GeneID" id="92356707"/>
    <dbReference type="KEGG" id="loi:92356707"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="573"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="598"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5465243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="685" mass="73877" checksum="6631509DCD2855FE" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GKN8</accession>
    <name>A0A836GKN8_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_04931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000014">
        <property type="protein sequence ID" value="KAG5483777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064716.1">
        <property type="nucleotide sequence ID" value="XM_067206907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GKN8"/>
    <dbReference type="GeneID" id="92360841"/>
    <dbReference type="KEGG" id="loi:92360841"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5483777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="207" mass="22841" checksum="45D97537D366A0A1" modified="2021-09-29" version="1">MELHLLPETDSFLQVLLRPTFAVSYSVMALLMLMSSYFTEMRTVENSSAPAVLVTRNLCVNVFTFTLCVATMAFANSTQITRAIALGQSPPMKLSVLRSLPWPLSAACGSQGDRKLVPFLLHSLIFPGTLVVVSLHLMSLGVNGVENALSWRMSLQRYLAWTMLWRLAVTAGVFTTNYLAAHNPTQSVLIPPMESDRPLSTTTVRPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GLH0</accession>
    <name>A0A836GLH0_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_03767</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061700.1">
        <property type="nucleotide sequence ID" value="XM_067205763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GLH0"/>
    <dbReference type="SMR" id="A0A836GLH0"/>
    <dbReference type="GeneID" id="92359697"/>
    <dbReference type="KEGG" id="loi:92359697"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5474594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="341" mass="35847" checksum="53C75ABAF520041C" modified="2021-09-29" version="1">MSSSLMPLCATAQRVKMLECGPCAIGSAMRKVSREGWTQPLADFAVDIVIGALALTSATEVLVPASLVHYVESCRVVAAQASGSAPTQWPWPAWDVALAEQRLVTLVAARDVARLVNGGCYGGAYRALCVPVPSGPLVAQLDFGTPVDTFYAEVLPGVLDAVGASGHVRWRAWMRSALTCAYEGTHVPPIRVAEYTSQLLRQTGGCESVMWEAAVKGLTPRWLETACKTALAVGVPPGSLALALPEESSCTARLLAKSVEVGVTSWATCAVVDSPLYPHASPLTSPQSVQLFATGWNDASATASSSYAGDAVDTAEESLVQCLDFVDAVTERFTALLRTCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GLI9</accession>
    <name>A0A836GLI9_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LSCM4_03797</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061730.1">
        <property type="nucleotide sequence ID" value="XM_067205793.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836GLI9"/>
    <dbReference type="GeneID" id="92359727"/>
    <dbReference type="KEGG" id="loi:92359727"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000049">
        <property type="entry name" value="cyclin-dependent kinase-like 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF400">
        <property type="entry name" value="KINASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="4"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="416"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="491"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="686"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="811"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="891"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1033"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1130"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1218"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1332"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1397"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1496"/>
            <end position="1539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="424"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="686"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="819"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="903"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="955"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="1042"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1080"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1148"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1173"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1231"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1398"/>
            <end position="1438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1440"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG5474624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1562" mass="164642" checksum="EC636943682739D7" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GQB6</accession>
    <name>A0A836GQB6_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_01105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5468018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059820.1">
        <property type="nucleotide sequence ID" value="XM_067203170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GQB6"/>
    <dbReference type="GeneID" id="92357104"/>
    <dbReference type="KEGG" id="loi:92357104"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5468018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="296" mass="31744" checksum="C0E2CF54D81C59F5" modified="2021-09-29" version="1">MSLRRAGAAAVMERRSEWIASLRSSLPQFTKRSAAPLVRGHAAAVIGPAPRRVLDEAIESLTATSSLLLPSKWREEATQQLITTLHGIVPPSQLKQTDYFLCSLIHPSYVQAGTMRCQSDSVRRRVQQELRRTVCMPLELTMAGSKSLRLLGELAEYVERGAAVAAASARTGSTHPDTQVGGKGEDGGSTSGPSSCSYYPLDASWPELNSADTTAFLQAFRQAGLEPLVLHDKKLFAASSTSTGDDGAVSSEVCLAAFTALCGSIELVSGWSSLLQFVDRVAREQRGLVRPSDGHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GRI0</accession>
    <name>A0A836GRI0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_06272</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAFHLR010000007">
        <property type="protein sequence ID" value="KAG5486807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065601.1">
        <property type="nucleotide sequence ID" value="XM_067208196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GRI0"/>
    <dbReference type="SMR" id="A0A836GRI0"/>
    <dbReference type="GeneID" id="92362130"/>
    <dbReference type="KEGG" id="loi:92362130"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051131">
        <property type="entry name" value="NEK_Ser/Thr_kinase_NIMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899">
        <property type="entry name" value="CAMK FAMILY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="4"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="263"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="358"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="476"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="661"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="713"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="791"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="369"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="723"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5486807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="863" mass="93819" checksum="7EE3BE7DA9CD413D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GRL0</accession>
    <name>A0A836GRL0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Electron transfer flavoprotein-ubiquinone oxidoreductase</fullName>
            <shortName evidence="19">ETF-QO</shortName>
            <ecNumber evidence="19">1.5.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">LSCM4_06318</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2 19">Accepts electrons from ETF and reduces ubiquinone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 19">
            <text>a ubiquinone + reduced [electron-transfer flavoprotein] = a ubiquinol + oxidized [electron-transfer flavoprotein] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24052"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.5.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="19">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="19">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ETF-QO/FixC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.1" evidence="19"/>
    <dbReference type="EMBL" id="JAFHLR010000007">
        <property type="protein sequence ID" value="KAG5486852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065646.1">
        <property type="nucleotide sequence ID" value="XM_067208241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GRL0"/>
    <dbReference type="SMR" id="A0A836GRL0"/>
    <dbReference type="GeneID" id="92362175"/>
    <dbReference type="KEGG" id="loi:92362175"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000015">
        <property type="entry name" value="Electron transfer flavoprotein-ubiquinone oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040156">
        <property type="entry name" value="ETF-QO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049398">
        <property type="entry name" value="ETF-QO/FixC_UQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007859">
        <property type="entry name" value="ETF-QO/FixX_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10617">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10617:SF107">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21162">
        <property type="entry name" value="ETFQO_UQ-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05187">
        <property type="entry name" value="Fer4_ETF_QO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 19" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9 19" id="KW-0274">FAD</keyword>
    <keyword evidence="6 19" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 19" id="KW-0408">Iron</keyword>
    <keyword evidence="14 19" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 19" id="KW-0813">Transport</keyword>
    <keyword evidence="15 19" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="20">
        <location>
            <begin position="533"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00052682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU366068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAG5486852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="574" mass="62545" checksum="16F47463539E6D4D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GSH1</accession>
    <name>A0A836GSH1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_01886</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">LSCM4</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 5"/>
    <dbReference type="EMBL" id="JAFHLR010000022">
        <property type="protein sequence ID" value="KAG5479294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063387.1">
        <property type="nucleotide sequence ID" value="XM_067203928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GSH1"/>
    <dbReference type="SMR" id="A0A836GSH1"/>
    <dbReference type="GeneID" id="92357862"/>
    <dbReference type="KEGG" id="loi:92357862"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000025">
        <property type="entry name" value="Peptidylprolyl isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050689">
        <property type="entry name" value="FKBP-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10516:SF443">
        <property type="entry name" value="FK506-BINDING PROTEIN 59-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10516">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="6">
        <location>
            <begin position="23"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5479294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="111" mass="11847" checksum="04FBAAD58E693E1D" modified="2021-09-29" version="1">MPLDAVVMDKIIEGDGKTIPRPGSVVTLDYIGYLEDGSKFDSTLERGKPFVFRVGCGEVIKGWDAGIVQMSKGERSKLTMPPSLAYGGTGFPGLIPPNATIVFEVTLLDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GSI8</accession>
    <name>A0A836GSI8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Guanine nucleotide-binding protein subunit beta-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_02541</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060120.1">
        <property type="nucleotide sequence ID" value="XM_067204568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GSI8"/>
    <dbReference type="SMR" id="A0A836GSI8"/>
    <dbReference type="GeneID" id="92358502"/>
    <dbReference type="KEGG" id="loi:92358502"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001185">
        <property type="entry name" value="WD_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002657">
        <property type="entry name" value="WD_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001566">
        <property type="entry name" value="WD_domain_-_G-beta_repeat_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
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            <fullName evidence="4">Ribosomal P protein AGP2beta-1</fullName>
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        <name evidence="2" type="ORF">LSCM4_02306</name>
    </gene>
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        <name type="scientific">Leishmania orientalis</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG5472980.1"/>
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        </location>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="235" mass="26079" checksum="6A65B4E059D37EF0" modified="2021-09-29" version="1">MNMSCADQGWVLLMALQENKDSYEVKALSLTEFVLQCADCQRLCLEKTARVVENRSRAPRGWESVFDAVAEERRTEDFRLCESRCRIMHTACPSRDKTRQYEEVLAAAAQKGKKGTPPNASVLQEASRCEHAVEALSSVLFALAHKPSKVSFPTKDLKAQDTKYGEPRDAAPTEAHRKALECAKAAQSALSSNWSKLRPDRLDRDRQHIASPADFSHDPNTAATSSASGATTPRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="5">Transmembrane protein</fullName>
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        <name evidence="3" type="ORF">LSCM4_01324</name>
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    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
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    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_067203379.1"/>
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    </dbReference>
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        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
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        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5466180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="375" mass="41148" checksum="9AE24FB7FD9733E1" modified="2021-09-29" version="1">MCARNLRAAARQWSFVMVLGTIFVAAYGLCLVADSRGNAADDMAGRGSVTSESEHGDHRYQGIPLHPFCGVEFSESYTVAIATTMPLEGCSPMTQVGQLYVDKAAGAARVDHVFRGQRTSFLVDNRHLRGFFFFDTASGDDAERSGSGSDGNNEGPSQRCHVFYLPRKVMPFCVPRRYTASSRESVVRGVPVTRFSGMERYDHTPLVEQSFYVLNATDAVGATPIAIPWRLELRARSDLEPSTISGAPYKPPNWRLFGHPMFDELVLSPAQESRLQTWVPAYNLLTVDFYNYYPATLKPDVFAVPPQCTAVLHKGTSTGGGAPEEASASKRNETASSTVTEPLLELATIQLFLIQWHALQNTSAGWHVAKKGDAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="4" type="ORF">LSCM4_01510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059250.1">
        <property type="nucleotide sequence ID" value="XM_067203559.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
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        <property type="entry name" value="RRM_dom"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="382"/>
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    </feature>
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        <location>
            <begin position="622"/>
            <end position="641"/>
        </location>
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        <location>
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        <location>
            <begin position="410"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="627"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="685"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5466360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="697" mass="73976" checksum="7FF64ECF1F746495" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GXE3</accession>
    <name>A0A836GXE3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Vps53 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_06463</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VPS53 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000019">
        <property type="protein sequence ID" value="KAG5480894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063895.1">
        <property type="nucleotide sequence ID" value="XM_067208383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GXE3"/>
    <dbReference type="SMR" id="A0A836GXE3"/>
    <dbReference type="GeneID" id="92362317"/>
    <dbReference type="KEGG" id="loi:92362317"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.110">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 53, C-terminus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039766">
        <property type="entry name" value="Vps53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031745">
        <property type="entry name" value="Vps53_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038260">
        <property type="entry name" value="Vps53_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007234">
        <property type="entry name" value="Vps53_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 53 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16854">
        <property type="entry name" value="VPS53_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04100">
        <property type="entry name" value="Vps53_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps53 N-terminal" evidence="8">
        <location>
            <begin position="27"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Vps53 C-terminal" evidence="9">
        <location>
            <begin position="629"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="822"/>
            <end position="845"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008628"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5480894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="881" mass="97358" checksum="F7D7D6AA50BD3FAD" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GXE4</accession>
    <name>A0A836GXE4_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_07259</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000015">
        <property type="protein sequence ID" value="KAG5483046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064542.1">
        <property type="nucleotide sequence ID" value="XM_067209159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GXE4"/>
    <dbReference type="SMR" id="A0A836GXE4"/>
    <dbReference type="GeneID" id="92363093"/>
    <dbReference type="KEGG" id="loi:92363093"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="119"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="264"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="694"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="726"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="367"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="606"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="742"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="765"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5483046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="935" mass="101025" checksum="CE9C1F4FC8B9A9C4" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GXG6</accession>
    <name>A0A836GXG6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cobalamin-independent methionine synthase MetE C-terminal/archaeal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_03090</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">LSCM4</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060660.1">
        <property type="nucleotide sequence ID" value="XM_067205108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GXG6"/>
    <dbReference type="GeneID" id="92359042"/>
    <dbReference type="KEGG" id="loi:92359042"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30519">
        <property type="entry name" value="5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE METHYLTRANSFERASE"/>
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    </dbReference>
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        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE C-terminal/archaeal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5471543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="115" mass="12667" checksum="D3C04113E03C13C5" modified="2021-09-29" version="1">MCYAEVNDVIKTIAAMDADVISIEASRSDMEPLTSFTDFTYPNGVGPGVYDIHSPNIPTTQSIVDLLLKAAQYLPVRQLWVNPDCGLKTRTWDECRAALHNMVAAAAELRSLKPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836GXL8</accession>
    <name>A0A836GXL8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal lipase-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_03166</name>
        <name evidence="4" type="ORF">LSCM4_03167</name>
        <name evidence="5" type="ORF">LSCM4_03168</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060734.1">
        <property type="nucleotide sequence ID" value="XM_067205182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836GXL8"/>
    <dbReference type="SMR" id="A0A836GXL8"/>
    <dbReference type="GeneID" id="92359116"/>
    <dbReference type="KEGG" id="loi:92359116"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051218">
        <property type="entry name" value="Sec_MonoDiacylglyc_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856:SF25">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044663487" description="Fungal lipase-type domain-containing protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="2">
        <location>
            <begin position="96"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="2">
        <location>
            <begin position="216"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5471617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5471618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5471619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="314" mass="34382" checksum="E42CF2FEDC673BCC" modified="2021-09-29" version="1">MYRLPPALRTVCGACVVVCALLASVAVAQKPYSFDEAWRAHFFSRAAYCSGRDVQSWTCGAACSSVGAFENRTVLDNMLFGTRGLAGVDHANRQIVVAYRGSDNIQNFLENINVLQVRYDKSSSCGRWCKVHAGFLDAYNSLRQQTRDAVLQLIQENPTYEVLVTGYSLGAAIAVLAAVDLQERLNSLEGSSALKPVSLYTFGGPRVGNSAFAKWTFGGPRVGNSAFAKWVDALLSKGAKYRITHGCDPVVRVPALLWGYAHSTTEVFYRTGSNDSAVVCNDSPGWEDWKCSLGMLSLWVPDHMRYLGDTVFCK</sequence>
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                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">LSCM4</strain>
        </source>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </source>
    </evidence>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836GY96_9TRYP</name>
    <protein>
        <submittedName>
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        </submittedName>
    </protein>
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    <organism evidence="7 8">
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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    <comment type="similarity">
        <text evidence="2">Belongs to the RRP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <source>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
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    <organism evidence="3 4">
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    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG5476132.1"/>
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    </dbReference>
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        <location>
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        </location>
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        <location>
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            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5476132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836H0A8_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
            <dbReference type="EMBL" id="KAG5482409.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
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</entry>
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        <name type="scientific">Leishmania orientalis</name>
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    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
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            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <sequence length="484" mass="56505" checksum="262BB2A0F84393C3" modified="2021-09-29" version="1">MFSKGYSVLLRPYQHVAFAKRSAAGGVKLNKGALTERERGDSFTEPEVYRSTKNVTAMLKTKRKERRLLEEERQSTMMNKLNLDARTEEALHAGRRLPQTPAEMQAVRSSDDAVAEVRCNSNEYSTTMRNLMRREVDRRDHVADKFGQPPTSREFYQLFRKLRSADSEEEAVERHQRRLVEEHGVYPSSRIDSYMLDDDSYFPDWVHALPYSIRDRVKYGSLGLTEEDEALRVRLARLPRDARLREWKRLKAAKEYRAANEETLTLAELRDVRQGKRRFHWLQRKRQKRASALRRMAMRKPEGHELWPSSVTDFSQRIAFIAQHVENGLQTGGKWPLDEDALTKAKIKRRQSEAERTFLMSLDEKKIAASAGRGGMHGGMKELLDALDEPEKRYKKLSRKTYANRVNAIVHGDQDEHGRQYRKLHNLATRRQRRFDSLAEMALEKEVRKEPLINVSGLNHTDDEHWSRHEKSWMDGLPSTRYGS</sequence>
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                <person name="Bates M.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474633.1"/>
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    <sequence length="120" mass="12851" checksum="5ED1A251B5B7E5F2" modified="2021-09-29" version="1">MEGTAYRNYVLHPHLFGATGVTSATESADEAFRGQRVDCQVNVLNDLVEYLIRARGSGDAALDPTVGATDSVEGSVPALPREHFFKIHNGCFVQTRQIASLTARCRCIAAAEGISVADVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAG5470320.1"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5470320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="218" mass="24192" checksum="362A25B7A2767C8C" modified="2021-09-29" version="1">MAEEKIKILVVGPLKSGKTTITNFLSGTRETPTSKYYETNPLRIVETEVELDSLRLSDRRVVFSGGDAKTKRAVVQIWDLSGSSKHQAGWPAVANKADGIIFVFNPAVKNGEKELSLWHKTFAVNQSELDAHGNVAIRVQDKHCLVFAHHSTHPSNVAGEGLPPMPKGLEKIKVLETSLDYHSENFKAAFDKLVESIVVARMEAEEDEVLQREGRMNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836H7P0_9TRYP</name>
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    </organism>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000006">
        <property type="protein sequence ID" value="KAG5487334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="518"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="790"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="798"/>
            <end position="810"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5487334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1084" mass="115684" checksum="BE281099E75E2302" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H862</accession>
    <name>A0A836H862_9TRYP</name>
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        </submittedName>
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    <organism evidence="2 3">
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        <lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="GeneID" id="92359352"/>
    <dbReference type="KEGG" id="loi:92359352"/>
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    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
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        <location>
            <begin position="103"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5471853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="189" mass="21312" checksum="4A41DC01F11C5591" modified="2021-09-29" version="1">MPLVRAELACREEERRVLVDERQHQTAGVRRTALVFCSSEPLAENLRLRELTVNLKILDCYEAFVDATSKLYTGKMDAKMLLMEGAKLSFAQRIRLAALGERAAGLLQQCEAYSRRINALQRQETDLSRKVYSMELEVAALRTELQRLEARRDTTECEVEKDREAAAASQVTAPKGVRGEPYNCAASTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H888</accession>
    <name>A0A836H888_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Band 7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_08109</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">LSCM4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000005">
        <property type="protein sequence ID" value="KAG5487664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="SPFH domain/band 7 family protein"/>
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        </source>
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        </source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836H9H1_9TRYP</name>
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        <recommendedName>
            <fullName evidence="1">Thioredoxin domain-containing protein</fullName>
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        <name evidence="3" type="ORF">LSCM4_03570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAFHLR010000029">
        <property type="protein sequence ID" value="KAG5473501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061503.1">
        <property type="nucleotide sequence ID" value="XM_067205566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H9H1"/>
    <dbReference type="SMR" id="A0A836H9H1"/>
    <dbReference type="GeneID" id="92359500"/>
    <dbReference type="KEGG" id="loi:92359500"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031397">
        <property type="term" value="P:negative regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030178">
        <property type="term" value="P:negative regulation of Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03009">
        <property type="entry name" value="TryX_like_TryX_NRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045870">
        <property type="entry name" value="TryX_NRX_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46472">
        <property type="entry name" value="NUCLEOREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46472:SF1">
        <property type="entry name" value="NUCLEOREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13905">
        <property type="entry name" value="Thioredoxin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="3"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5473500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5473501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="144" mass="16157" checksum="120E2D546B32BF7E" modified="2021-09-29" version="1">MSGLSKYLGEVAKLQNQNSEVDVSSLSGKLVFFYFSASWCPPCRGFTPQLAEFYNKHSGPKNFEVVLATWDEEEDDFATYYAKMPWLAIPFAKRSLVETLSKAFEVTSIPTMIGIDADSGEVVTRGARHALTMDPEGDKFPWRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H9N6</accession>
    <name>A0A836H9N6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">valine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Valyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LSCM4_02240</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>tRNA(Val) + L-valine + ATP = L-valyl-tRNA(Val) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="2"/>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061311.1">
        <property type="nucleotide sequence ID" value="XM_067204274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836H9N6"/>
    <dbReference type="SMR" id="A0A836H9N6"/>
    <dbReference type="GeneID" id="92358208"/>
    <dbReference type="KEGG" id="loi:92358208"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00817">
        <property type="entry name" value="ValRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.380:FF:000001">
        <property type="entry name" value="Valine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000126">
        <property type="entry name" value="Valine--tRNA ligase chloroplastic/mitochondrial 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000009">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000020">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000005">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="entry name" value="Valyl-tRNA synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02004">
        <property type="entry name" value="Val_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019499">
        <property type="entry name" value="Val-tRNA_synth_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004349">
        <property type="entry name" value="PRK05729.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946:SF109">
        <property type="entry name" value="VALINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="VALYL-TRNA SYNTHETASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10458">
        <property type="entry name" value="Val_tRNA-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="tRNA-binding arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="13">
        <location>
            <begin position="21"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="14">
        <location>
            <begin position="692"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="domain" description="Valyl-tRNA synthetase tRNA-binding arm" evidence="15">
        <location>
            <begin position="906"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="904"/>
            <end position="931"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF10458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAG5472915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="974" mass="109990" checksum="F1179D33B5C52064" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836H9X1</accession>
    <name>A0A836H9X1_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calpain catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_02121</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061194.1">
        <property type="nucleotide sequence ID" value="XM_067204157.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="loi:92358091"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="272"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="502"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="751"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="918"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="926"/>
            <end position="938"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5472798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1365" mass="148771" checksum="CB63B743402966AA" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HA25</accession>
    <name>A0A836HA25_9TRYP</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">LSCM4_02213</name>
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        <name type="scientific">Leishmania orientalis</name>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061284.1">
        <property type="nucleotide sequence ID" value="XM_067204247.1"/>
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    <dbReference type="GeneID" id="92358181"/>
    <dbReference type="KEGG" id="loi:92358181"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5472888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="117" mass="12486" checksum="6BE039D7081F2561" modified="2021-09-29" version="1">MNPGRALSGARTRTQPEMSPLRPPLSCSSPMQLPLRFVSLQSRRKALASCRRRRQLSGGDDGMSVHTEMDGEEGETSGGIASPLYVSVCVCVCVDGETLGHIVLSFGLASFFAAPFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HB40</accession>
    <name>A0A836HB40_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
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            </authorList>
            <dbReference type="PubMed" id="34489462"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="protein sequence ID" value="KAG5473458.1"/>
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            <end position="326"/>
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        <location>
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            <end position="605"/>
        </location>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="358"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="590"/>
            <end position="605"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5473458.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="605" mass="65408" checksum="DF92A88B39E8393F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HBN1</accession>
    <name>A0A836HBN1_9TRYP</name>
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        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
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        <name evidence="2" type="ORF">LSCM4_03907</name>
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        <name type="scientific">Leishmania orientalis</name>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061837.1">
        <property type="nucleotide sequence ID" value="XM_067205900.1"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5474731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="32189" checksum="F9EBDD284C77073B" modified="2021-09-29" version="1">MLRRLYAVHATAGMALLAGQAARSRSHTAASAPSTQSPSPFHALCIPRRGFMDSFFGRSQEKVKLDDVAYDKSAPRYSGTIFGLPADNVIFYSKVATGTLATLVVVYIFFKGYVVLSRFSLQTVARLGFMSGFASCLVCYTVALSLVRRYRINAETVYNQSIALVMHNEKVVQHLGTHPRTGDFRTYNATGGFKLPLMRRIRSGSYELSDLLGLKQRRLQMLLTLKNPSSGNEGLVSCDVRKESTGFLTSTNVYKSLSITLYSENKKTEPETIILIGKPEDVVYRSLILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HDF9</accession>
    <name>A0A836HDF9_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_04321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
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                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HGI9</accession>
    <name>A0A836HGI9_9TRYP</name>
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        <recommendedName>
            <fullName evidence="3">C-CAP/cofactor C-like domain-containing protein</fullName>
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        <name evidence="4" type="ORF">LSCM4_06441</name>
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        <name type="scientific">Leishmania orientalis</name>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Jariyapan N."/>
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                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
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                <person name="Bates P.A."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="1">Belongs to the TBCC family.</text>
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    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000019">
        <property type="protein sequence ID" value="KAG5480873.1"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="EMBL" id="KAG5480873.1"/>
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            <dbReference type="Proteomes" id="UP000674143"/>
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    <sequence length="3055" mass="319225" checksum="634C02542D19C43D" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5478001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062908.1">
        <property type="nucleotide sequence ID" value="XM_067207340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HHL0"/>
    <dbReference type="GeneID" id="92361274"/>
    <dbReference type="KEGG" id="loi:92361274"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5478001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="246" mass="24874" checksum="AAB4E6373C74451E" modified="2021-09-29" version="1">MAKNPVPTTVAAVVGEVIANATSTSTPSSTEPPFPSTSPTPADGWTIDSAILWLVTVFYFAVSGAALAYFVSRWRRRVYGNDRVLRGGSGADGGGAGANTIATGEGLLGTIGAMIERATSITALAGAAAWRRSESARYRSTSQGSSARHRAGGAASGGGRGRSWLGGLALFLPGAQARSAAAKRNKQKSDDGHVDSDALPTVWSEGAGVGGAGHGGVIGGSAVPSSSMGPTMTARDQQQQQQRGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HI96</accession>
    <name>A0A836HI96_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-type proton ATPase proteolipid subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_04623</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Vacuole membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000023">
        <property type="protein sequence ID" value="KAG5478391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063052.1">
        <property type="nucleotide sequence ID" value="XM_067206605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HI96"/>
    <dbReference type="SMR" id="A0A836HI96"/>
    <dbReference type="GeneID" id="92360539"/>
    <dbReference type="KEGG" id="loi:92360539"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18175">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18176">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000001">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011555">
        <property type="entry name" value="ATPase_proteolipid_su_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01100">
        <property type="entry name" value="V_ATP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="10">
        <location>
            <begin position="17"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="10">
        <location>
            <begin position="94"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5478391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="167" mass="17025" checksum="1C494C0DCA930BE2" modified="2021-09-29" version="1">MSSTKSCDPEAFLFGMMGAAVSLALANVGAAFGTAKAGVAVAQLGIVQPTRVMRGIVPVVMAGILGIYGLIVSVIICNNMKLSGYPLFSGYMHLGAGLAAGFASLAAGYAIGIVGDICCYAYAKTEKIFVPMILMLIFAEALGLFGLITALLMNNKATSVIGSCVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HJP1</accession>
    <name>A0A836HJP1_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5478060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062967.1">
        <property type="nucleotide sequence ID" value="XM_067207399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HJP1"/>
    <dbReference type="GeneID" id="92361333"/>
    <dbReference type="KEGG" id="loi:92361333"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5478060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="153" mass="17132" checksum="8BA5A17B3000BBA8" modified="2021-09-29" version="1">MRKLRGFEPHLQQSFCARAVSSTIGAAEGDVHAASSPAQGDGTLGPKKRGQQNCAKGAEFWQKEKVTPTWTRTRVIGFRVRGDNRYTIGARKRKPRWRMITIIGKRISTIRRLCILDGTLLSGAPSGDIHNLEIQQRRLALSLRKADVNLREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HKE3</accession>
    <name>A0A836HKE3_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_04683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000023">
        <property type="protein sequence ID" value="KAG5478450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063111.1">
        <property type="nucleotide sequence ID" value="XM_067206664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HKE3"/>
    <dbReference type="GeneID" id="92360598"/>
    <dbReference type="KEGG" id="loi:92360598"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032707">
        <property type="entry name" value="MYCBPAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48421">
        <property type="entry name" value="MYCBP-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48421:SF1">
        <property type="entry name" value="MYCBP-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="912"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="912"/>
            <end position="924"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5478450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1071" mass="115676" checksum="61A96B127C6C2291" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HM38</accession>
    <name>A0A836HM38_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="12">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="12">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LSCM4_01897</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">LSCM4</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>tRNA(Ala) + L-alanine + ATP = L-alanyl-tRNA(Ala) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="12"/>
    <dbReference type="EMBL" id="JAFHLR010000022">
        <property type="protein sequence ID" value="KAG5479305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063398.1">
        <property type="nucleotide sequence ID" value="XM_067203939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836HM38"/>
    <dbReference type="SMR" id="A0A836HM38"/>
    <dbReference type="GeneID" id="92357873"/>
    <dbReference type="KEGG" id="loi:92357873"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070143">
        <property type="term" value="P:mitochondrial alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00673">
        <property type="entry name" value="AlaRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.130:FF:000015">
        <property type="entry name" value="Alanine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.310.40:FF:000001">
        <property type="entry name" value="Alanine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000011">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000004">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050058">
        <property type="entry name" value="Ala-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777:SF9">
        <property type="entry name" value="ALANINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777">
        <property type="entry name" value="ALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 12" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alanyl-transfer RNA synthetases family profile" evidence="13">
        <location>
            <begin position="6"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="602"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="606"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="727"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="731"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG5479305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="962" mass="105705" checksum="560A94F3F1305F5B" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836HPK1</accession>
    <name>A0A836HPK1_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000017">
        <property type="protein sequence ID" value="KAG5481811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064171.1">
        <property type="nucleotide sequence ID" value="XM_067208797.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836HPK1"/>
    <dbReference type="GeneID" id="92362731"/>
    <dbReference type="KEGG" id="loi:92362731"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000011">
        <property type="protein sequence ID" value="KAG5485305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065042.1">
        <property type="nucleotide sequence ID" value="XM_067207868.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836HYQ5"/>
    <dbReference type="GeneID" id="92361802"/>
    <dbReference type="KEGG" id="loi:92361802"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004694">
        <property type="term" value="F:eukaryotic translation initiation factor 2alpha kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13996">
        <property type="entry name" value="STKc_EIF2AK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001895">
        <property type="entry name" value="eIF-2 alpha kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF136">
        <property type="entry name" value="EIF-2-ALPHA KINASE GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RWD" evidence="8">
        <location>
            <begin position="74"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="329"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="409"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1275"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="450"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="480"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5485305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1297" mass="143795" checksum="F6F4A9615FD86689" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836I086</accession>
    <name>A0A836I086_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000009">
        <property type="protein sequence ID" value="KAG5486100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065431.1">
        <property type="nucleotide sequence ID" value="XM_067208720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836I086"/>
    <dbReference type="SMR" id="A0A836I086"/>
    <dbReference type="GeneID" id="92362654"/>
    <dbReference type="KEGG" id="loi:92362654"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5486100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="279" mass="32636" checksum="8B43805525136D7E" modified="2021-09-29" version="1">MPPLHSRATRQLVKERNKIEGPRSLHRGIHYEENEAHASTYMRNSNKKRADHRDLLVHHQRINEDLQDIYARTAALHSDNMTMEERIEESWKRFERIGGKRPTNVRARGQDAVLCANQSGVPYAERLAQVSQQKKELRERAAWERLTHGEAVDYSQGSALHAAKDKRVQMFQRRQLRRAHVLRRVGDPTPLKQSGTYDMNSGTLQVFNKTIRNVQREVAHDARIAEFRKRRKDSRSQWDVKESGNVNRPDQEVLRYSRDWELGPRRKAGGGRKRGRNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836I220</accession>
    <name>A0A836I220_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_06378</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S5A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000007">
        <property type="protein sequence ID" value="KAG5486910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067065704.1">
        <property type="nucleotide sequence ID" value="XM_067208299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836I220"/>
    <dbReference type="SMR" id="A0A836I220"/>
    <dbReference type="GeneID" id="92362233"/>
    <dbReference type="KEGG" id="loi:92362233"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000005">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027040">
        <property type="entry name" value="PSMD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02809">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="4">
        <location>
            <begin position="7"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="243"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="294"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5486910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="344" mass="36678" checksum="585865A8869CDF0A" modified="2021-09-29" version="1">MVEACFLCLDSTEYMRNGDQYPTRMMAEQDAACLLTNAKLQANAENTLGFLTTGGNACTVYETLTNNVDAIMTSIGSVPINGKRCNFSAGLQIASLALSHRTNSRAEKRIVAFVGSPVRETEAELEVLAKKLRKDDVAVDVVAFGVEENVELLQAFVKKVCKKENSRFLAVGARENLTDKLMSNAILLGEDLPEGAGGGGAGMGGFGVDPNMDPELAMALRLSMEDEMQRQAAAAAAVASSAAPESVPASGNNATPTVAIAPAPAPVVDEDDLNYENMSEEEMMRRAIALSLQETTQGSSDATPPPSAPQPLTSTPHENEEENLEDFSKCVEDALEKEDEEKHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836K6P4</accession>
    <name>A0A836K6P4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribose-phosphate diphosphokinase</fullName>
            <ecNumber evidence="2">2.7.6.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LSCM4_00576</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="2"/>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058755.1">
        <property type="nucleotide sequence ID" value="XM_067202654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836K6P4"/>
    <dbReference type="SMR" id="A0A836K6P4"/>
    <dbReference type="GeneID" id="92356588"/>
    <dbReference type="KEGG" id="loi:92356588"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000002">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002320">
        <property type="entry name" value="PRK01259.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF113">
        <property type="entry name" value="SYNTHETASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="11">
        <location>
            <begin position="12"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAG5465124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="358" mass="39184" checksum="8FE15084E13547B9" modified="2021-09-29" version="1">MESCNSRNGSLRVVHGNANPKLAKDVCRYLNIPVTASRVGSFANGETIVKILESIRGDDIFVIQPTCGNSTGTNVNQAVMELLLIIHTLKLSSARRVIAVIPHYGYARQDRKHTGRVPISASAVARMVTEMGVNGVVTMDLHCGQIQGFFHGCPVADLSPSSEFAEYVKQKKFNPSNLVVVAPDAGAVNRARRMGDRIGASRIVTILKRRVVANQVESMQLVGEVEGCVCIIVDDMIDTAGTLCKAAEVLKEYGAKEVHAYATHGIFTDPACERLTQCAALVEVVVTDSIPQEESTRKCNKIKVISIAKLLADAIYRMHSEESLETVGQPEHFMPKREDDLQPLESLVEEDEWARVNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836K7U6</accession>
    <name>A0A836K7U6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_01565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059304.1">
        <property type="nucleotide sequence ID" value="XM_067203613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836K7U6"/>
    <dbReference type="SMR" id="A0A836K7U6"/>
    <dbReference type="GeneID" id="92357547"/>
    <dbReference type="KEGG" id="loi:92357547"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5466414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="38703" checksum="8450506A220D2735" modified="2021-09-29" version="1">MVSWWPFQRRRESTPAGGASPSSSNDEGGEAKVPRPRSLLETESYDNAVSGRDRGYGDSGVPYSQFDRMRDEQKIRRHGDGRASTMDVESIDMLVSHYEQEFREADAHMKVRKTQRSLLQRYDYANDRRYQQWTREQKEMREKLKIHWLDWMIDQPLYCLVYYLRVCTSAGFCFGAGRTAYLYRTMDKTYAKLNGVTLGSIAFQEITTSVAKGGVIALMGTIGVPVGDALMNLCITLRTGDVSSPQRTWWHILNSSICSGFLGGAAYVGLNYKQLTPWGARALLLLSTGCGAAAGLYLGYFVYRPYAAQRTHSLYVPYWRPWHTRHQRDAGPSNFRGKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836K9A0</accession>
    <name>A0A836K9A0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_00332</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase E subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058517.1">
        <property type="nucleotide sequence ID" value="XM_067202416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836K9A0"/>
    <dbReference type="SMR" id="A0A836K9A0"/>
    <dbReference type="GeneID" id="92356350"/>
    <dbReference type="KEGG" id="loi:92356350"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033178">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, catalytic domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2320.30">
        <property type="entry name" value="ATP synthase, E subunit, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038495">
        <property type="entry name" value="ATPase_E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002842">
        <property type="entry name" value="ATPase_V1_Esu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45715">
        <property type="entry name" value="ATPASE H+-TRANSPORTING V1 SUBUNIT E1A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01991">
        <property type="entry name" value="vATP-synt_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160527">
        <property type="entry name" value="V-type ATPase subunit E-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="4"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5464886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="216" mass="25270" checksum="52681E334388FEF1" modified="2021-09-29" version="1">MSEARQIQSMIDFIEREAQEKAEELDAAAQEEYDVEKMRLVEAEKMKIRAMAEKKRKQVDVDRRVARANYSKVQRMRVMEERAKTMEKLHEQTRQKIVAMINNPSKYKPMLVSLIHQSLMSIRTDAVIQCRQEDVAEVEREISQLERWYKEKTGDTISIQTSKTYLNTAEVWGGVVVMSTDGRVVCNNTLSYRTKTCFDEQLPTVRFHLFNPEAPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836K9E8</accession>
    <name>A0A836K9E8_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Guanine nucleotide-binding protein subunit beta-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_00518</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat PRL1/PRL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058697.1">
        <property type="nucleotide sequence ID" value="XM_067202596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836K9E8"/>
    <dbReference type="SMR" id="A0A836K9E8"/>
    <dbReference type="GeneID" id="92356530"/>
    <dbReference type="KEGG" id="loi:92356530"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000347">
        <property type="entry name" value="Pre-mRNA-splicing factor PRP46, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045241">
        <property type="entry name" value="Prp46/PLRG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19923:SF0">
        <property type="entry name" value="PLEIOTROPIC REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19923">
        <property type="entry name" value="WD40 REPEAT PROTEINPRL1/PRL2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="1 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="182"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="224"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="266"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="308"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="481"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5465066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="509" mass="54859" checksum="D02ADE8FEC53AAFE" modified="2021-09-29" version="1">MNQTSPEELLSANAASAQELHGVAVLDAPSFDPDAPLRTCSGHRKDTKTILSEAMGLRANLLWRALYPRSAPPTTATVTTSSSAGIDAAAATQSNASARDAVLAGVLTVANSTPSGGSSNRSAAASSGALTLKRGRDEDNILSMSPEQLKVRSALVVSKAAAEEAEARQYSSPPKWKLAKVLVGHQGWVWATAVEPGNKWFATGGFDAIIKVWDLETGTLKMNLTGHKEAVRSIALSKVSPYMFSGSDDHSVKCWDLERNEVVREFFGHKSSVHCIAAHPSLDVVISGSRDKTVRVFDLRTRAVVHTMVGHTDSVMSLLVQQEEPQVLSGGSDGYIYLWDLASGKPFQRLTRHKKPVRGLAFTAAGDALVSCGADEVRVWKLPSGDFITNASTRVLEDRKVISAARAGAGATDEAEEYSYRWSCCAMSPHNVLAVASQDGELAFYDWNYPQPRRVAGKYYAPYQWTKTKSLPGTLQGEGGVNAITFDASGTRLITGESDKSVKIWRMRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836K9K1</accession>
    <name>A0A836K9K1_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LSCM4_00716</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058892.1">
        <property type="nucleotide sequence ID" value="XM_067202791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836K9K1"/>
    <dbReference type="GeneID" id="92356725"/>
    <dbReference type="KEGG" id="loi:92356725"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAG5465261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="477" mass="52473" checksum="287554F1088BDCFA" modified="2021-09-29" version="1">MGDLRDELDATVLFGSGYVCVVGPPSSGKTTLVLEYLVARERLALRSGDADAVAFCVEYVSARSASHGLLRYLTHRLLPNARRRRLSYECTPLEFGASLIEWAETHPEQSELHVVIDDADMLEYSTEEIDLWLSYCLRAPVRHSFTVILWLISELPLRLSNCFRYHFIARPEAQRIVQWLQRQFEEEHRLFGDPESEAEDSEGAVDTAPTATLRAEDVNRVVLDAFAYYSTHQPMCSTVVSRDVRLLIQRVYQILPPLLLEVTAAAPIVSAETGEATVSASTTTSAVKKLNARHFAAAWSQCRTDGGGGASSAMAASGAGDGGAAAAQSPLVMALKRLGYSAVLLAFAAFYGGAVPKRKQYQVFGRMGSAERRAPVHEAKGQSHKAAVLSASAHVLTVRRLGFLYDAMLRMCTPHIDPLEFTTSDVAMHHVQGFVAWGLLTPVVSQRHRSYHCWIPVSTAQQLARELSLNLFDLIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KAH2</accession>
    <name>A0A836KAH2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Guanine nucleotide-binding protein subunit beta-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LSCM4_01521</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat WDR55 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059261.1">
        <property type="nucleotide sequence ID" value="XM_067203570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KAH2"/>
    <dbReference type="GeneID" id="92357504"/>
    <dbReference type="KEGG" id="loi:92357504"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050505">
        <property type="entry name" value="WDR55/POC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019:SF20">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="453"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAG5466371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="630" mass="67675" checksum="B29899DFDF19A7A8" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KBF7</accession>
    <name>A0A836KBF7_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Short chain 3-hydroxyacyl-CoA dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LSCM4_00115</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.35"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058306.1">
        <property type="nucleotide sequence ID" value="XM_067202205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KBF7"/>
    <dbReference type="SMR" id="A0A836KBF7"/>
    <dbReference type="GeneID" id="92356139"/>
    <dbReference type="KEGG" id="loi:92356139"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000009">
        <property type="entry name" value="Fatty oxidation complex, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052242">
        <property type="entry name" value="Mito_3-hydroxyacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43561">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43561:SF3">
        <property type="entry name" value="HYDROXYACYL-COENZYME A DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="13">
        <location>
            <begin position="14"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="12">
        <location>
            <begin position="199"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="10">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG5464675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="33194" checksum="078F5FB9765E3DA1" modified="2021-09-29" version="1">MLRRTSSARFKSLVVWGGGTMGGGIAQVAAQASVPVTVVEVSQARVDAARKAMETSLGRIAKKKCDGDQSKMKAFVETVLSHVKFTTDEATAASGAELIIEAIVENIDAKKALFGRLDKIAPKSTVFCSNTSSLSIAEMASVTTRRARFAGMHFFSPVPLMKLLEVVRTEEVQPEIVEQLKAFGKKVGKIAVVTKDTEGFIVNRLLVPYQMEACRLVERGVATLQDVDTAMKFGCGYPMGPFELSDSIGIDVIKFIVDGWHTRHPNEPLFRPSPLINERVSAGKLGKKTGEGFYKYDSTGRKIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KBM0</accession>
    <name>A0A836KBM0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial import inner membrane translocase subunit TIM50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LSCM4_01443</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TIM50 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059187.1">
        <property type="nucleotide sequence ID" value="XM_067203496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KBM0"/>
    <dbReference type="SMR" id="A0A836KBM0"/>
    <dbReference type="GeneID" id="92357430"/>
    <dbReference type="KEGG" id="loi:92357430"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000159">
        <property type="entry name" value="TFIIF-stimulated CTD phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
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    <keyword evidence="1" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="1" id="KW-0811">Translocation</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="55"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="180"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="281"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="199"/>
            <end position="229"/>
        </location>
    </feature>
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        <location>
            <begin position="337"/>
            <end position="346"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="357"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="388"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAG5466297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="399" mass="43968" checksum="CB7362EDA6F23751" modified="2021-09-29" version="1">MTDSPQKLIPPPNGSALLRENLFEDKTDDDEGELLKRREPTMLLKGQKLIAPASDGTKRYTVVFDLDETVVYARDGPLYARAYLKDLFRFMKDDFEVIVWTAGERDYAKCILEEINEDHIVKHLVYRHEKWFREEDYTKDLRQLGRDLNYTLMIENTPDCVRANPQNGIIVEDFEVLPETTEEEGSMPVTPVPTPPPAQVAETTAATNEAKESAAPQASTTTGPRSTTESGGGGSHSPPRRRRTTDRTLFLLRELLQSLVKSGETVPSFLASCELLSRQTVTGSDGHDIPIYHLGTRRRRKDAGVQRKQVRVNRDRSPAAATTAEVSLSLPDAPAESSANSKTVSTDGRDGGGVAHSSDSSADTSQLHPAGTPRQSGNDQLECTHAMGVDKEKEGASHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KBN1</accession>
    <name>A0A836KBN1_9TRYP</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_00346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5464900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058531.1">
        <property type="nucleotide sequence ID" value="XM_067202430.1"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A836KBN1"/>
    <dbReference type="GeneID" id="92356364"/>
    <dbReference type="KEGG" id="loi:92356364"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="25"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="320"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5464900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="551" mass="62765" checksum="32FCDFB27126FB87" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KBU0</accession>
    <name>A0A836KBU0_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_00532</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000036">
        <property type="protein sequence ID" value="KAG5465080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067058711.1">
        <property type="nucleotide sequence ID" value="XM_067202610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KBU0"/>
    <dbReference type="GeneID" id="92356544"/>
    <dbReference type="KEGG" id="loi:92356544"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051213">
        <property type="entry name" value="START_lipid_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308">
        <property type="entry name" value="PHOSPHATIDYLCHOLINE TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308:SF51">
        <property type="entry name" value="START DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="12"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="892"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="356"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="892"/>
            <end position="901"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5465080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="994" mass="107615" checksum="90EAECBC5BCB3E75" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KBY5</accession>
    <name>A0A836KBY5_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="7">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_01139</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="7"/>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5468051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059853.1">
        <property type="nucleotide sequence ID" value="XM_067203203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KBY5"/>
    <dbReference type="SMR" id="A0A836KBY5"/>
    <dbReference type="GeneID" id="92357137"/>
    <dbReference type="KEGG" id="loi:92357137"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF888">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="6"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5468051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="898" mass="101872" checksum="1C904B601C448B39" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KD39</accession>
    <name>A0A836KD39_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">H(+)-transporting two-sector ATPase</fullName>
            <ecNumber evidence="2">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LSCM4_01094</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5468007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059809.1">
        <property type="nucleotide sequence ID" value="XM_067203159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KD39"/>
    <dbReference type="SMR" id="A0A836KD39"/>
    <dbReference type="GeneID" id="92357093"/>
    <dbReference type="KEGG" id="loi:92357093"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18111">
        <property type="entry name" value="ATP-synt_V_A-type_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18119">
        <property type="entry name" value="ATP-synt_V_A-type_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01134">
        <property type="entry name" value="V_A-ATPase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1140.10:FF:000002">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000002">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000008">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000052">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00309">
        <property type="entry name" value="ATP_synth_A_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031686">
        <property type="entry name" value="ATP-synth_a_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005725">
        <property type="entry name" value="ATPase_V1-cplx_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022878">
        <property type="entry name" value="V-ATPase_asu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003220">
        <property type="entry name" value="PRK04192.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01042">
        <property type="entry name" value="V-ATPase_V1_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607:SF1">
        <property type="entry name" value="H(+)-TRANSPORTING TWO-SECTOR ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607">
        <property type="entry name" value="V-TYPE PROTON ATPASE CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16886">
        <property type="entry name" value="ATP-synt_ab_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="11">
        <location>
            <begin position="18"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="ATPsynthase alpha/beta subunit barrel-sandwich" evidence="12">
        <location>
            <begin position="120"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="10">
        <location>
            <begin position="225"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase A/B type C-terminal" evidence="13">
        <location>
            <begin position="460"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF22919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAG5468007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="610" mass="67547" checksum="8E03043D016C2575" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KDV6</accession>
    <name>A0A836KDV6_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_02935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000032">
        <property type="protein sequence ID" value="KAG5470241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060507.1">
        <property type="nucleotide sequence ID" value="XM_067204955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KDV6"/>
    <dbReference type="GeneID" id="92358889"/>
    <dbReference type="KEGG" id="loi:92358889"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5470241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="162" mass="19192" checksum="377B88761F8C486B" modified="2021-09-29" version="1">MAGAPPLSFVRAAARTLQHDVQTFTRWDPSVNKLQCAIRDAAYLIIDLPRFFMYSHSNYGAMRRYIRQSRINKGKINPEDFKEVDTNVLRESLIKYAQTKGPLQKIDFRWFYWMYAVMIIYAGWQGMHLQSLLDARVDRMGASLEQRRDMFDDDYLEEVRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KFU5</accession>
    <name>A0A836KFU5_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_02618</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000033">
        <property type="protein sequence ID" value="KAG5469220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060197.1">
        <property type="nucleotide sequence ID" value="XM_067204645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KFU5"/>
    <dbReference type="SMR" id="A0A836KFU5"/>
    <dbReference type="GeneID" id="92358579"/>
    <dbReference type="KEGG" id="loi:92358579"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5469220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="248" mass="26328" checksum="F4AAEEDD0294A62B" modified="2021-09-29" version="1">MFSAAVTNTVAAAVGQFRPVKHVARYGVAASGGLCMIRPRKSSVCDKNCAIILGCVLSGCVLIAFFIFMWCCLAAKRRREQRRRLKGVACLKGHLSIAEEEVGINEGSATVPASATVERDILPSFLSANAYSPASPLASWSPKSGISYPLKNVSAADSSGSAGAVERELSTRSPIAEDQVLPLSQKQLNPLAPQIEATQSNDAQQEGGKPQATKPNRKPRLRRKNLIRGVSAAACPEDSATSIEDHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KHA4</accession>
    <name>A0A836KHA4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LSCM4_02085</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061158.1">
        <property type="nucleotide sequence ID" value="XM_067204121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KHA4"/>
    <dbReference type="SMR" id="A0A836KHA4"/>
    <dbReference type="GeneID" id="92358055"/>
    <dbReference type="KEGG" id="loi:92358055"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009445">
        <property type="entry name" value="TMEM85/Emc4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19315">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06417">
        <property type="entry name" value="EMC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAG5472762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="246" mass="27725" checksum="B647AE227F9F7530" modified="2021-09-29" version="1">MTPLTPLSGSLFLRLRVLDVLHRTRDSLSHRHIPTHTPTLAHETQISALLRLPPLPPPPCISSYTHPHRISGTVHHRLPPTPPLLLLHSLPFGSEAMASTALNANAAAKQMTDEEITRHRIMTRLNDIRTQPLKQLPMTAFMMWMVGNDVSIFSIMFVGMAVVNPLQSILGAGKMFADFEEDAKTDRQIRSAVNQARWIYIGCCLIAFLVALVKLNWMELLPVNSMDWMDNTPPTYQEFSIGTFYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KHU6</accession>
    <name>A0A836KHU6_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_01275</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAFHLR010000035">
        <property type="protein sequence ID" value="KAG5466133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059023.1">
        <property type="nucleotide sequence ID" value="XM_067203332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KHU6"/>
    <dbReference type="SMR" id="A0A836KHU6"/>
    <dbReference type="GeneID" id="92357266"/>
    <dbReference type="KEGG" id="loi:92357266"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14016">
        <property type="entry name" value="STKc_CK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001265">
        <property type="entry name" value="Casein kinase I, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="22"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5466133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="332" mass="38312" checksum="45AC98794DE4F633" modified="2021-09-29" version="1">MVRGKSKSPRLLENCLVQGGRFRVGRRLGGGSFGEIFEGVDTRTGEMVAIKVERAKTAHPQLLTESQHYSLVSQGRAAAYMPTIFGYSSESDFNVMAMELMGLSLEDLHEQCGNRFSLKTTLMLADQILWLIEIVHSRGILHRDIKPENFIMGRGKKAHHVYIIDFGLAKKYRDPRTHAHIPYKEGKSLTGTARYCSINTHLGVEQGRRDDMEGIGYLLIYLLRGSLPWQGLKAPNKDQKYNMIAHLKMSTSVESLCKDLPIEFASLMNYSRALRFEDRPDYGYLRAMFRRLFEREGYQEDYVYDWTVRNMQEKLTARQRKRTESKLGKKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KJ81</accession>
    <name>A0A836KJ81_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nuclear cap-binding protein subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">20 kDa nuclear cap-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LSCM4_01976</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the RRM NCBP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000030">
        <property type="protein sequence ID" value="KAG5472655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061051.1">
        <property type="nucleotide sequence ID" value="XM_067204014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KJ81"/>
    <dbReference type="SMR" id="A0A836KJ81"/>
    <dbReference type="GeneID" id="92357948"/>
    <dbReference type="KEGG" id="loi:92357948"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005846">
        <property type="term" value="C:nuclear cap binding complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12240">
        <property type="entry name" value="RRM_NCBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027157">
        <property type="entry name" value="NCBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034148">
        <property type="entry name" value="NCBP2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18847">
        <property type="entry name" value="20 KD NUCLEAR CAP BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18847:SF0">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="42"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAG5472655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="188" mass="21108" checksum="E2C1092E1C25421A" modified="2021-09-29" version="1">MSSDLVDTLPRMQYVDRHELLRSLLTTEEFRVRRQEQLDYSTTVYVGNLSFYTTEEQLYHHFSPCGHIRDMVMGLNEETRRPCGFCFVVFESQAAAVLAVQELDGSLLDDRVVSVGWDVGCDRSRRWGRGAHGGQVVDGVRQNLDEGRGGLGALRRDALGLTALTAAEEQVAYEWVSAPPKRRGGNTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KJC1</accession>
    <name>A0A836KJC1_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_05359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5477964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062871.1">
        <property type="nucleotide sequence ID" value="XM_067207303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KJC1"/>
    <dbReference type="GeneID" id="92361237"/>
    <dbReference type="KEGG" id="loi:92361237"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="814"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="944"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="998"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="950"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="998"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1041"/>
            <end position="1050"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5477964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="1090" mass="116653" checksum="9990F4B46CBA2788" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KL94</accession>
    <name>A0A836KL94_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">B9 domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_04374</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">LSCM4</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000025">
        <property type="protein sequence ID" value="KAG5477157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062568.1">
        <property type="nucleotide sequence ID" value="XM_067206359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KL94"/>
    <dbReference type="GeneID" id="92360293"/>
    <dbReference type="KEGG" id="loi:92360293"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036038">
        <property type="term" value="C:MKS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010796">
        <property type="entry name" value="C2_B9-type_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12968">
        <property type="entry name" value="B9 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12968:SF2">
        <property type="entry name" value="B9 DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07162">
        <property type="entry name" value="B9-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51381">
        <property type="entry name" value="C2_B9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5477157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="183" mass="20394" checksum="EAB992AD54372A1C" modified="2021-09-29" version="1">MSELHIIGEINCGHDFGDSSYFCSYEIITGTQWTAVEGRTSGATHVMRSGSDGIPWSYPIDVHYSFSNVQGWPKIAIQVWQLDDYGCKDIAGYGTAYLPMPGHGEQELSVSTWRPSLWSSSALVRFWQALRLLIMGGYPVLRDNSLIADNEQRFKLHTIATGTVKMSFMVIGRGMKQAGLMYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KM00</accession>
    <name>A0A836KM00_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_06221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000020">
        <property type="protein sequence ID" value="KAG5480454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067063785.1">
        <property type="nucleotide sequence ID" value="XM_067208145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KM00"/>
    <dbReference type="GeneID" id="92362079"/>
    <dbReference type="KEGG" id="loi:92362079"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032407496" evidence="1">
        <location>
            <begin position="16"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5480454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="309" mass="32826" checksum="1B71AF2946B12676" modified="2021-09-29" version="1">MRALRCCSAVMPARALVAAAAGSQLRWTAHEARTQVPRSCVLARWTGAAAKAAETNPSLLGKGLSFASGLVRDASPSTRSASTNAAIDSTVGDVLWDLCERMDYYVQYNIPSSWRVTELLRDNSIAIQCSPPPLIETAEGSDAAVHGISLNCFAYKQRVKEADSVRLLHVFLKRFNASVNNSLELLSEGHPPRSLQAELKGPANGTSRGALDAGMAASTQAGDAGNGEGTCETLAKQLNSAVAEVTFTPGPGQPLAHGLCRAFYNSNGRFHYVIVVAVPEEEYVNSVDLMIHALASVVESRVEAAAKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KPA3</accession>
    <name>A0A836KPA3_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Guanine nucleotide-binding protein subunit beta-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LSCM4_06866</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000017">
        <property type="protein sequence ID" value="KAG5481791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064151.1">
        <property type="nucleotide sequence ID" value="XM_067208777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KPA3"/>
    <dbReference type="SMR" id="A0A836KPA3"/>
    <dbReference type="GeneID" id="92362711"/>
    <dbReference type="KEGG" id="loi:92362711"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45333:SF1">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_625, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45333">
        <property type="entry name" value="MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="443"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="484"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="526"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="278"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAG5481791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="698" mass="74281" checksum="28555D186B263EA5" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KPK2</accession>
    <name>A0A836KPK2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Guanine nucleotide-binding protein subunit beta-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LSCM4_05484</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000024">
        <property type="protein sequence ID" value="KAG5478085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067062992.1">
        <property type="nucleotide sequence ID" value="XM_067207424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KPK2"/>
    <dbReference type="SMR" id="A0A836KPK2"/>
    <dbReference type="GeneID" id="92361358"/>
    <dbReference type="KEGG" id="loi:92361358"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010992">
        <property type="term" value="P:ubiquitin recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001534">
        <property type="entry name" value="WD domain, G-beta repeat/PFU (PLAA family ubiquitin binding), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.870">
        <property type="entry name" value="PFU (PLAA family ubiquitin binding), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015155">
        <property type="entry name" value="PFU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038122">
        <property type="entry name" value="PFU_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013535">
        <property type="entry name" value="PUL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849:SF0">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09070">
        <property type="entry name" value="PFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08324">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51394">
        <property type="entry name" value="PFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51396">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="59"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="162"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="204"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="245"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="290"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="PFU" evidence="9">
        <location>
            <begin position="396"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="PUL" evidence="10">
        <location>
            <begin position="529"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="498"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="514"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAG5478085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="836" mass="89352" checksum="1DEDFEDCF06EC3D2" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KQN7</accession>
    <name>A0A836KQN7_9TRYP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_03826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000028">
        <property type="protein sequence ID" value="KAG5474653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067061759.1">
        <property type="nucleotide sequence ID" value="XM_067205822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KQN7"/>
    <dbReference type="GeneID" id="92359756"/>
    <dbReference type="KEGG" id="loi:92359756"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5474653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="183" mass="20303" checksum="3D1475133144862B" modified="2021-09-29" version="1">MNELEHFVASTHGSRCDIMRYMQQLRDLDERIEYHLAHLRFIAAERVAYQAAQARGTHSDRRGGRVWAGVSRGARGRESRTRGVGRTSVSNAATLHAHHEDVDASPKAEDGVDGDEDAIAAAYVAELQRQFAWHETCVQRQCHERDAIAAELVERCCEVRLSMASRLANFASVADASVTELSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KSR4</accession>
    <name>A0A836KSR4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nrap protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LSCM4_07096</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NRAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000018">
        <property type="protein sequence ID" value="KAG5481385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064064.1">
        <property type="nucleotide sequence ID" value="XM_067209001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836KSR4"/>
    <dbReference type="SMR" id="A0A836KSR4"/>
    <dbReference type="GeneID" id="92362935"/>
    <dbReference type="KEGG" id="loi:92362935"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005554">
        <property type="entry name" value="NOL6/Upt22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035368">
        <property type="entry name" value="Nrap_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035369">
        <property type="entry name" value="Nrap_D4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035370">
        <property type="entry name" value="Nrap_D5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972">
        <property type="entry name" value="NUCLEOLAR RNA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17404">
        <property type="entry name" value="Nrap_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17405">
        <property type="entry name" value="Nrap_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17406">
        <property type="entry name" value="Nrap_D5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Nrap protein" evidence="3">
        <location>
            <begin position="444"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="4">
        <location>
            <begin position="637"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="5">
        <location>
            <begin position="844"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="158"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="749"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1166"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="160"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1240"/>
            <end position="1257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU364032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAG5481385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1271" mass="138772" checksum="09FBA4DE2DA903AC" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836KST4</accession>
    <name>A0A836KST4_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_07908</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000013">
        <property type="protein sequence ID" value="KAG5484342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067064835.1">
        <property type="nucleotide sequence ID" value="XM_067209785.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A836KST4"/>
    <dbReference type="GeneID" id="92363719"/>
    <dbReference type="KEGG" id="loi:92363719"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010828">
        <property type="term" value="P:positive regulation of D-glucose transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090314">
        <property type="term" value="P:positive regulation of protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031340">
        <property type="term" value="P:positive regulation of vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038983">
        <property type="entry name" value="C2CD5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057815">
        <property type="entry name" value="C2CD5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056431">
        <property type="entry name" value="C2CD5_YbjQ-rel_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37412">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37412:SF2">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23025">
        <property type="entry name" value="YbjQ_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23128">
        <property type="entry name" value="YbjQ_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="558"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="657"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="716"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1054"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1130"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1267"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1595"/>
            <end position="1616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1680"/>
            <end position="1701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2007"/>
            <end position="2041"/>
        </location>
    </feature>
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        <location>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
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                <person name="Al-Salem W.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    </organism>
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            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <end position="96"/>
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    </feature>
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        <location>
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    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5486892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836KVG7_9TRYP</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">LSCM4_07891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
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        <lineage>
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            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
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                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">LSCM4</strain>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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            <begin position="41"/>
            <end position="60"/>
        </location>
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        </source>
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        <source>
            <dbReference type="EMBL" id="KAG5484325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="325" mass="34899" checksum="DF80E89254CE9599" modified="2021-09-29" version="1">MDVFHLLSLVVDLRDYPGYATCARATEYPGLALCEYNAAAGMRYTVPLGYAASVVYFYLYHRPRLSFADRSLTKLHHYFYPSAGYSAPLGIVGGVLYGAVDCVQELTPAALEAAAAREKTAAVMAAEQYNQRHRAAKKRLNAEQSLASKALVWLRLREDPVQAALARMGLGEDNMAWETLLVPQGYLWTQLHSVVHDPARYRGYGVPIAASSASPTSTEASLGQSCGAAQALCSSSPGSVSPSGAYFTKPQVDAVVSRIGTLRASPEDDRWMRSAGRCGAYGIFGMLLTWNSGGALFRALMGLGLGVTIGGLASATRLDELFTHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Leishmania orientalis</name>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">LSCM4</strain>
        </source>
    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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            <begin position="531"/>
            <end position="540"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0A836L1Q6_9TRYP</name>
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        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="4" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5485678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FNP1</accession>
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        <name evidence="2" type="ORF">LSCM4_01249</name>
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        <lineage>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAG5466107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
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    </evidence>
    <sequence length="230" mass="24891" checksum="6B1BF75874EED88B" modified="2021-09-29" version="1">MPPKRGAMAQAIRDAYNEETSLAVVEEWSSKVVADLETRATNARRARQGVLAKPYTPEAAETVPVSVVVSLREFQGQLHDIYRAAETIRTVIACRIPELKAEDNLGVEVQMTVLKMIDSLEGKLLGGSGADKDGGAPGVAGMYATRDYLAARGSVEDKVLGKAGENGKETKSAAPSVLMELQQIDADALLKLELSATQISTQIRSFINTYALNWKKLIQPRSNSCEKNIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="10">Elongation factor 4 homolog</fullName>
            <shortName evidence="10">EF-4</shortName>
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        <alternativeName>
            <fullName evidence="10">GTPase GUF1 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ribosomal back-translocase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LSCM4_00821</name>
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        <name type="scientific">Leishmania orientalis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." volume="10" first="0" last="0">
            <title>LGAAP: Leishmaniinae Genome Assembly and Annotation Pipeline.</title>
            <authorList>
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                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz-Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
            </authorList>
            <dbReference type="PubMed" id="34292068"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2021" name="Sci. Data" volume="8" first="0" last="0">
            <title>Chromosome-scale genome sequencing, assembly and annotation of six genomes from subfamily Leishmaniinae.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Urbaniak M.D."/>
                <person name="Bates M.D."/>
                <person name="Jariyapan N."/>
                <person name="Kwakye-Nuako G."/>
                <person name="Thomaz Soccol V."/>
                <person name="Al-Salem W.S."/>
                <person name="Dillon R.J."/>
                <person name="Bates P.A."/>
                <person name="Gatherer D."/>
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            <dbReference type="PubMed" id="34489462"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the GTP-binding elongation factor family. LepA subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.n1" evidence="10"/>
    <dbReference type="EMBL" id="JAFHLR010000034">
        <property type="protein sequence ID" value="KAG5467742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067059544.1">
        <property type="nucleotide sequence ID" value="XM_067202894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836FRD9"/>
    <dbReference type="SMR" id="A0A836FRD9"/>
    <dbReference type="GeneID" id="92356828"/>
    <dbReference type="KEGG" id="loi:92356828"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097177">
        <property type="term" value="F:mitochondrial ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01890">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000187">
        <property type="entry name" value="Translation factor GUF1 homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002566">
        <property type="entry name" value="Translation factor GUF1 homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2570:FF:000001">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="entry name" value="Elongation factor 4, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512:SF7">
        <property type="entry name" value="TRANSLATION FACTOR GUF1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="TRANSLATION FACTOR GUF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="2 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="12">
        <location>
            <begin position="136"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="488"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="500"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="145"/>
            <end position="152"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="212"/>
            <end position="216"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="266"/>
            <end position="269"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAG5467742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <sequence length="846" mass="92403" checksum="95D4723D0F504CE2" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836FYB2</accession>
    <name>A0A836FYB2_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Coiled-coil domain-containing protein 39</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LSCM4_03115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2021-02" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania (Mundinia) orientalis Genome sequencing and assembly.</title>
            <authorList>
                <person name="Almutairi H."/>
                <person name="Gatherer D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">LSCM4</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAFHLR010000031">
        <property type="protein sequence ID" value="KAG5471567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_067060684.1">
        <property type="nucleotide sequence ID" value="XM_067205132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A836FYB2"/>
    <dbReference type="SMR" id="A0A836FYB2"/>
    <dbReference type="GeneID" id="92359066"/>
    <dbReference type="KEGG" id="loi:92359066"/>
    <dbReference type="Proteomes" id="UP000674143">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060285">
        <property type="term" value="P:cilium-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036159">
        <property type="term" value="P:inner dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033290">
        <property type="entry name" value="CCDC39"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18962">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18962:SF0">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24161">
        <property type="entry name" value="CCDC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="15"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="127"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="253"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="456"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="667"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAG5471567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000674143"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="859" mass="99731" checksum="9D77DD305EA2DC3F" modified="2021-09-29" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2021-09-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A836G006</accession>
    <name>A0A836G006_9TRYP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MRH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LSCM4_00558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania orientalis</name>
        <dbReference type="NCBI Taxonomy" id="2249476"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2021" name="Microbiol. Resour. Announc." 